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Georgian Medical News

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https://www.readbyqxmd.com/read/29328045/assessment-of-the-level-of-knowledge-of-medical-personnel-in-diarrhea-and-hemolytic-uremic-syndrome
#1
O Chokoshvili, N Vepkhvadze, T Tsertsvadze, T Gabrichidze, M Khorbaladze
Survey have been conducted among medical professionals to test knowledge level of HUS and diarrheal diseases and to identify predictor variables for better knowledge. Cross-sectional survey have been conducted among medical personnel at different clinics in Tbilisi and in regions of Georgia. Participants were selected from different clinics in Tbilisi and in three biggest regional cities (Zugdidi, Batumi and Kutaisi) of Georgia. A total of 12 clinics were selected from them 6 were in Tbilisi and 2 at each regional cities...
December 2017: Georgian Medical News
https://www.readbyqxmd.com/read/29328044/a-computer-modeling-study-of-binding-properties-of-chiral-nucleopeptide-for-biomedical-applications
#2
M Pirtskhalava, A Egoyan, M Mirtskhulava, G Roviello
Nucleopeptides often show interesting properties of molecular binding that render them good candidates for development of innovative drugs for anticancer and antiviral therapies. In this work we present results of computer modeling of interactions between the molecules of hexathymine nucleopeptide (T6) and poly rA RNA (A18). The results of geometry optimization calculated using Hyperchem software and our own computer program for molecular docking show that molecules establish stable complexes due to the complementary-nucleobase interaction and the electrostatic interaction between the negative phosphate group of poly rA and the positively-charged residues present in the cationic nucleopeptide structure...
December 2017: Georgian Medical News
https://www.readbyqxmd.com/read/29328043/complementary-and-alternative-medicine-and-medical-education-in-georgia-state-of-the-art-and-further-perspectives
#3
I Nadareishvili, K Lunze, G Pkhakadze, N Japiashvili, N Tabagari
Aim - complementary and alternative medicine (CAM) is popular in Georgia, but providers' training not well understood or regulated. The aim of this mixed-methods study was to inform the process of implementing quality CAM curricula in Georgia and strategies for the inclusion of effective CAM curricula into medical education in Georgia. We analyzed existing medical curricula. We conducted a contextual analysis based of qualitative data collected from relevant medical education experts, qualified physicians, CAM practitioners and other stakeholders; and administered a quantitative MD students' survey to MD students...
December 2017: Georgian Medical News
https://www.readbyqxmd.com/read/29328042/dynamics-of-changes-in-indices-of-endogenous-intoxication-in-patients-with-acute-small-intestinal-obstruction-in-case-of-reamberin-use-in-the-comprehensive-treatment
#4
V Skrypko, A Kovalenko, E Talikova
The objective of this research was to study changes in parameters, characterizing endogenous intoxication in patients with acute small bowel obstruction with Reamberin included into therapy scheme. Full physical examination and surgical treatment of 202 patients with acute small bowel obstruction were conducted. The control group included 30 healthy individuals. Dynamics of such clinical biochemical parameters as medium mass molecules (MMM), malondialdehyde (MDA), diene conjugates (DC) in blood serum were analyzed in preoperative period and on the 1st, 5th and 14th day of postoperative period...
December 2017: Georgian Medical News
https://www.readbyqxmd.com/read/29328041/von-willebrand-factor-immunohistochemical-staining-quantitative-optical-density-parameters-in-the-endothelium-and-fibrinoid-of-the-placenta-during-secundines-inflammation-and-concomitant-iron-deficiency-anemia-in-gravidas
#5
V Ilika, I Davydenko
The aim of the research was to set the optical density quantitative parameters of the von Willebrand factor immunohistochemical staining (vWF) in the endothelium and fibrinoid of the placenta during the secundines inflammation concomitant with iron deficiency anemia in gravidas. The total number of 198 placentas was studied. The immunohistochemical technique was performed using the visualization of the primary antibodies to vWF with a diaminobenzidine dye polymer system. The optical density of the histochemical staining was measured by means of computer microdensitometry after the digital copies of the images had been obtained...
December 2017: Georgian Medical News
https://www.readbyqxmd.com/read/29328040/expression-of-cyclin-e-in-basal-like-breast-carcinoma
#6
A Mariamidze, L Gogiashvili, O Khardzeishvili
Results of study under 362 patients biopsy materials in Tbilisi National Cancer Center were shown that basal-like type breast carcinoma is characterizes by different reaction on Cyclin E, CK5/17 and ER/PR immunoreactivities. Basal-like tumor immunoreactivity on Cyclin E differs based they clinical stage and seen maximum correlation with III-IV stage and poor prognosis.
December 2017: Georgian Medical News
https://www.readbyqxmd.com/read/29328039/influence-of-metabolic-syndrome-on-condition-of-microcirculatory-bed-of-oral-cavity
#7
O Denga, T Pyndus, V Gargin, S Schneider
Metabolic syndrome (MS) can be characterized as the clustering of combination of impaired glucose regulation, metabolic disorders accompanied by abdominal obesity, hyperglycemia, high blood pressure and dyslipidemia. Detection of changes in microcirculatory bed (MCB) of oral cavity in metabolic syndrome could be important for completion of gap for developing of adequate therapeutical measure for prevention of pathological periodontal disorder that was the purpose of our study. We performed experimental investigation with modulation of MS (on white male rats 1...
December 2017: Georgian Medical News
https://www.readbyqxmd.com/read/29328038/quantitative-assessment-of-the-results-of-vimentin-immunohistochemical-examination-in-fibroblasts-and-endotheliocytes-of-the-placental-villi-in-the-aspect-of-preterm-maturation-of-the-chorionic-tree-and-iron-deficiency-anemia-of-gravidas
#8
О Garvasiuk, І Davydenko
The objective of our study was to investigate quantitative parameters of vimentin in fibroblasts and endotheliocytes of the chorionic villi by means of immunohistochemical examination of placenta with preterm maturation of the chorionic tree with iron-deficiency anemia of pregnancy in two different terms of gestation - 29-32 weeks and 33-36 weeks. 182 placentas were examined. The study design included two main groups of investigation of the above terms of gestation and three groups of comparison. Quantitative parameters of vimentin in the cytoplasm of fibroblasts and endotheliocytes of the placenta intermediate and terminal villi were considered on the basis of staining optic density measured by means of computer microdensitometry method...
December 2017: Georgian Medical News
https://www.readbyqxmd.com/read/29328037/-implementation-of-the-right-for-health-care-for-children-internally-displaced-persons-certain-aspects
#9
S Buletsa, Y Lazur, M Mendzhul, О Pushkarenko
The aim of the article is to do a research on selected issues related to realizing the right for health сare for the children - internally dislocated persons. In order to achieve the given aim statistical data of the quantity of involuntarily dislocated persons including children and also the quantity of children registered with the health-care authority as well as the quantity of their requests for medical care have been analized. It has been determined that in case of involuntary dislocation children are more often exposed to trauma than adults which leads to different emotional disorders...
December 2017: Georgian Medical News
https://www.readbyqxmd.com/read/29328036/-structure-and-risk-factors-for-congenital-malformations
#10
Y Uteuliyev, V Balkibekova, A Saktapov, K Konysbayeva, V Atarbayeva, N Iskakova
Congenital malformations and anomalies occupy leading positions in the structure of infant mortality and disability. In order to reduce the risk of children with these disorders, it is necessary to carefully study the causes of congenital malformations. In this connection, the structures and risk factors of congenital malformations of the fetus were studied and recommendations for the improvement of preventive measures were developed. When studying the structure of congenital malformations of the fetus in Almaty, hereditary and acquired causes of congenital malformation are identified...
December 2017: Georgian Medical News
https://www.readbyqxmd.com/read/29328035/assessment-of-neurodevelopmental-outcomes-in-infants-6-12-months-of-age-according-to-impact-of-perinatal-risk-factors
#11
N Tskimanauri, N Khachapuridze, P Imnadze, T Chanadiri, S Bakhtadze
The purpose of this research was to investigate the developmental follow-up of infants (at age of 6 month and 12 month), exposed to separate and combination impact of perinatal risk factors, compared with not exposed cases, within the prospective cohort study. Between January 2015 and January 2017, in this research we prospectively enrolled 1018 live-born infants from the medical reports of the participating clinics in Tbilisi (capital of Republic of Georgia) and Mtskheta, Dusheti (districts of Georgia). Within postnatal follow-up, the children from whole population were assessed at 6 and 12 months of age by family doctors using the Denver Developmental Screening Test (Denver II)...
December 2017: Georgian Medical News
https://www.readbyqxmd.com/read/29328034/characteristics-of-articular-syndrome-in-systemic-vasculitis
#12
O Syniachenko, O Khaniukov, Ye Yehudina, H Taktashov, K Gashynova
The purpose of the study - investigation the separate joint lesion in systemic vasculitis, their X-ray sonographic characteristics, the correlation of the articular syndrome severity with extra-articular manifestations of the diseases, as well as aspects of the arthritis pathogenesis in this category of patients. The study included 525 patients in the ratio of the examined with Henoch-Schonlen purpura, microscopic polyangiitis, cryoglobulinemic vasculitis, polyarteritis nodosa, Takayasu's arteritis, Wegener's granulomatosis with polyangiitis and eosinophilic granulomatosis with polyangiitis Churg-Strauss as a 7:4:3:1:1:1:1...
December 2017: Georgian Medical News
https://www.readbyqxmd.com/read/29328033/-elemental-status-of-patients-with-various-forms-of-vitiligo
#13
N I Tsiskarishvili, A Katsitadze, N V Tsiskarishvili, I Charischarishvili
Vitiligo is a multifactorial disease in which, in each specific case of its manifestation, different mechanisms of its pathogenesis and different levels of melanin formation in the skin can be involved. Skin is one of the most metabolically active organs. Carrying out a number of vital functions (barrier, protective, respiratory, excretory, metabolic, immune, etc.), it needs microelementss. Of the 92 naturally occurring chemical elements, 81 are found in the human body. Lack of the vital elements, leads to the emergence of diseases, which are based on deficiency, excess or imbalance of micro- and macroelements in the body...
December 2017: Georgian Medical News
https://www.readbyqxmd.com/read/29328032/-tactics-of-choosing-cognitive-dysfunction-therapy-in-the-postoperative-period
#14
S Dubivska, O Kudinova, Yu Grigorov, N Bitchuk
The aim of the study is to formulate the tactics of assigning adequate neuroprotective therapy to patients with postoperative cognitive dysfunctions on the basis of subtracting the indicator of the total cognitive deficiency. To achieve this goal, we conducted a study of cognitive function in patients of different age groups: young age, middle age, elderly age with acute surgical pathology before surgery and at 1, 7, 30 days after surgery compared with preoperative data. Methods of research. The study of the cognitive sphere: scale MMSE, test drawing hours, test "10 words", battery tests for frontal dysfunction, method Schulte...
December 2017: Georgian Medical News
https://www.readbyqxmd.com/read/29328031/metabolic-profile-of-serum-fatty-acids-in-patients-with-comorbidity-of-chro-nic-obstructive-pulmonary-disease-and-chronic-pancreatitis
#15
N Zhelezniakova, L Pasiyeshvili, T Bocharova, T Pasiieshvili, O Zhelezniakov
Objective - study of blood serum fatty acid metabolic profile in patients with comorbidity of COPD and chronic pancreatitis. 238 patients were examined, of them 131 with combined COPD and chronic pancreatitis and 107 with isolated COPD run. In study of fatty acid spectrum biological materials were prepared and gas chromatography analysis of blood serum lipid fatty acid spectrum performed according to methodology by L.V.Sazonenko et al. The study showed that COPD exacerbation was accompanied with by changes in contents of particular fatty acids both in patients with isolated COPD and in patients with comorbidity in comparison with almost healthy patients...
December 2017: Georgian Medical News
https://www.readbyqxmd.com/read/29328030/modern-approaches-to-fractional-exhaled-nitric-oxide-as-a-useful-biomarker-for-allergic-asthma-phenotyping-and-management
#16
N Mgaloblishvili, M Gotua
Asthma is a pathologically heterogeneous disease, consisting of several phenotypes. Different types of airway inflammation are the cornerstone feature of this condition. Fraction of nitric oxide in exhaled air (FENO) has been proposed as a noninvasive, specific biomarker for eosinophilic airway inflammation and has been shown to be elevated in patients with allergic asthma phenotype. More recent studies indicate that FeNO identifies T-helper cell type 2 (Th2)-mediated airway inflammation with a high predictive value for identifying inhaled corticosteroid (ICS) responsive airway inflammation...
December 2017: Georgian Medical News
https://www.readbyqxmd.com/read/29328029/-metabolic-secretion-in-reproductive-age-women-with-obesity
#17
A Malazonia, T Zerekidze, N Vekua, N Chkheidze, K Asatiani
For the last decade melatonin has attracted attention as a neuroregulator in pathogenesis of obesity and metabolic syndrome. The aim of our study is to evaluate the characteristics of metabolic secretion in obese women of reproductive age. The study was conducted on the total number of 120 women. Eighty women with obesity formed the case group, and forty healthy women - the control group. Carbohydrate metabolism, lipid profile and serum levels of melatonin were evaluated in all study subjects. According to the results, 61...
December 2017: Georgian Medical News
https://www.readbyqxmd.com/read/29328028/-skin-pathology-in-diabetes-mellitus-clinical-and-pathophysiological-correlations-review
#18
K Kochet, I Lytus, I Svistunov, O Sulaieva
Skin pathology is registered in vast majority of patients with diabetes mellitus (DM). Despite the abundance of publications on dermatological problems in DM, there is still a number of gaps to be discussed in terms of pathophysiological mechanisms. The goal of this review was to assess the mechanisms of development of different skin pathologies under DM. One of the key pathogenic mechanisms of skin lesions in diabetes is hyperglycemia and the effects of the advanced glycation end products, inducing oxidative stress, endothelial dysfunction and inflammation; that in its turn can accelerate the mechanisms of skin aging, the development of diabetic dermopathy and scleredema diabeticorum...
December 2017: Georgian Medical News
https://www.readbyqxmd.com/read/29328027/the-impact-of-12-month-growth-hormone-replacement-therapy-on-lipid-metabolism-and-adipose-tissue-distribution-in-georgian-patients-with-adult-growth-hormone-deficiency
#19
N Bostoganashvili, T Zerekidze, Sh Janjgava, M Lomidze
Growth hormone deficiency (GHD) is one of the reasons of significant metabolic morbidities inchildren and adults. The aim of our study was to evaluate the impact of growth hormone (GH) replacement therapy on lipid profile and adipose tissue distribution in adults with GHD. Twenty hypopituitary adults, aged 40.75±2.2 years (mean ± SE, range 20.5-60), with adult onset GHD (aGHD) were enrolled in a randomized, double blind, placebo-controlled study. 10 patients received recombinant growth hormone injection once weekly for 12 months, and the rest 10 patients (as control group) received placebo...
December 2017: Georgian Medical News
https://www.readbyqxmd.com/read/29328026/clinical-efficacy-of-s-adenosylmethionine-in-patients-with-non-alcoholic-steatohepatitis-and-chronic-kidney-disease-i-ii-stage
#20
A Antoniv, N Antofiychuk, T Danylyshina, I Trefanenko, V Shuper
The article presents a theoretical generalization of the results of the clinical efficacy of S-adenosylmethionine in patients with non-alcoholic steatohepatitis (NASH) in comorbidity with obesity and chronic kidney disease (CKD) of the 1st-2nd stages. The objective of the article was to determine the likely effect of S-adenosylmethionine and Meldonium on the clinical course of non-alcoholic steatohepatitis (NASH) and chronic kidney disease (CKD) of the I-II stages. We examined 75 patients with NASH with comorbid obesity I degree and CKD I and II dgrees...
December 2017: Georgian Medical News
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