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Georgian Medical News

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https://www.readbyqxmd.com/read/28628026/-dynamics-of-occurrence-and-regression-of-neutrophil-extracellular-traps-in-the-experimental-model-of-the-wound-infectious-inflammatory-process
#1
I Nesterova, A Evglevsky, G Chudilova, S Kovaleva, L Lomtatidze
The dynamics of the appearance and regression of neutrophilic extracellular traps (NETs) in the experimental model of the wound infectious-inflammatory process that was caused by infection of open wounds by microbes surrounding environment, was studied. It was established that on the second day from the start of the experiment a significant number of mature neutrophilic granulocytes show the ability to form NEТs. The number of NETs was reached its maximum by the 2th and 4th days from the beginning of the experiment, that was associated with maximum occurrence of symptoms of inflammation in the wound...
May 2017: Georgian Medical News
https://www.readbyqxmd.com/read/28628025/-phenotype-facilities-of-lymphocytes-in-hemorrhagic-fever-with-renal-syndrome
#2
M Ivanov, I Balmasova, Z Vasnyova
Hemorrhagic fever with renal syndrome (HFRS) is a feral herd disease caused by hantaviruses. HERS may be severe and its manifestations include acute renal failure, intoxication, hemorrhages and pain syndrome. Hantaviruses as pathogen of HFRS wield considerable influence on the character of the immune response, in particular, is capable of lymphocytic cytolysis suppressing. It was found that cytotoxic T lymphocytes along with NKT and CD8 + regulatory T cells play the key role in the immune mechanisms of hemorrhagic fever with renal syndrome...
May 2017: Georgian Medical News
https://www.readbyqxmd.com/read/28628024/-evaluation-of-dynamic-telomere-length-shortening-of-lymphocytes-in-immunocompromised-children-with-chronic-diseases-of-the-respiratory
#3
E Khalturina, I Nesterova
Nowadays it is common to observe the growth of viral-viral and viral-bacterial co-infections in children of different ages, due to dysfunction of lymphocytes (DL), which can be connected with the process of the accelerated shortening of the end structures of chromosomal telomeres, telomere length changes are described in lymphocytes of children with chronic mono-infections. The conducted study has shown the shortening of telomere lymphocytes in children with CDRT seropositive for mixed-herpes viral infections (herpes simplex virus, virus, Epstein-Barr virus and cytomegalovirus in various combinations) and for bacterial co-infections - Chlamydia trachomatis and (or) Mycoplasma pneumoniae...
May 2017: Georgian Medical News
https://www.readbyqxmd.com/read/28628023/-ragweed-allergy-in-the-south-of-russia-in-the-chechen-republic
#4
D Macharadze, H Janaeva, K Avilov
Allergy to ragweed pollen and other weeds is a global problem due to the rapid spread of these grasses around the world. In addition, pollen of short ragweed (Ambrosia, Amb) and mugwort (Artemisia, Art) - one of the main causes of respiratory allergy - seasonal allergic rhinoconjunctivitis (hay fever) with/without bronchial asthma patients living in the South of Russia. Epidemiological studies on the prevalence of Allergy to Amb and Art among patients living in Chechen Republic, absent. Aim - of this retrospective study was to investigate the prevalence of sensitization to weed pollen in patients of Chechnya...
May 2017: Georgian Medical News
https://www.readbyqxmd.com/read/28628022/-estimation-of-parameters-of-external-respiration-of-students
#5
T Valishvili, M Chikhladze, S Gamkrelidze
The close relationship of the respiratory system with other systems and organs, its significant participation in the processes of metabolism once again proves the exceptional role of the study of respiratory function. On the other hand, the health of students is one of the most important social tasks of modern society. The aim of the study was detection of parameters of external respiration in students of Georgia. 235 students 18 to 21 of ages, were involved in the study, who underwent computer spirometry with Spiro lab 3 to achieve the aim of study...
May 2017: Georgian Medical News
https://www.readbyqxmd.com/read/28628021/correlation-between-spirometry-dates-and-special-allergen-specific-ige-in-patients-with-bronchial-asthma-in-west-georgia
#6
R Sepiashvili, M Chikhladze, D Khachapuridze, S Gamkrelidze
The study aimed to establish correlation between airway obstruction and specific IgE specificity, managing future treatment in the patients with bronchial asthma, among the population of west Georgia. In the study have been involved 56 patients (among them 24 males and 32 females) of different ages, with diagnostic bronchial asthma (according to GINA recommendation). On the ground of the aim the study included the following steps of allegro-diagnostics: I step - Computerized spirometry by apparatus ,,SPIROLAB 3"...
May 2017: Georgian Medical News
https://www.readbyqxmd.com/read/28628020/-study-of-cytotoxic-activity-of-methanol-extracts-of-the-endemic-plant-of-the-genus-erysimum-of-the-adjarian-floristic-district-of-georgia
#7
D Beridze, M Metreveli, M Joxadze, K Bakuridze, D Berashvili, A Bakuridze
According to the results, investigated methanolic extracts of endemic plant from Adjarian floristic region of Georgia do not have specific cytotoxicity against the cell lines of breast adenocarcinoma MCF-7 human, which is typical, e.g., for plant pigment curcumin. At the same time, the high specific cytotoxicity of 2 and 3 fractions towards keratinocytes gives reason for considering endemic plant extracts, of Adjarian floristic region of Georgia, as a potential pharmacological means for topical treatment of pathologies caused by increased proliferation of keratinocytes, such as psoriasis...
May 2017: Georgian Medical News
https://www.readbyqxmd.com/read/28628019/-study-of-lipids-of-the-fruits-of-usual-hazel-nut-corylus-avellana-l-growing-in-georgia
#8
B Kikalishvili, N Gorgaslidze, D Zurabashvili, Ts Sulakvelidze, M Malania, D Turabelidze
The aim of this investigation was the study of lipids from the fruits of usual hazel-nut Corylus avellana L, growing in Georgia. Ripe fruits was collected in the West Georgia, just in Imereti. From the powdered fruits was obtained the sums of neutral and pollar lipids. Qualitatively there were established classes entered in them. By using High performance liquid chromatography qualitatively and quantitatively were identified ten fatty acids, which time of deduction hesitate from 4,01 min to 13,00 min. By the analyses there were determined unsaturated fatty acids C12:0 to C24:0...
May 2017: Georgian Medical News
https://www.readbyqxmd.com/read/28628018/autoimmune-limbic-encephalitis-case-reports
#9
K Kobaidze, A Harrison, Y Burklin, V Patidar, M Riccardi
Limbic encephalitis (LE) is an autoimmune or paraneoplastic disease that affects the medial temporal lobes. The patient will usually present with cognitive impairment, psychiatric changes, and seizures. Autoimmune limbic encephalitis (LE) is a challenging diagnosis as it is not always included in the typical paraneoplastic/autoimmune panels. Anti-GAD antibodies are associated with various disease including type I diabetes mellitus, various autoimmune processes, some neoplastic and infectious diseases. Thus, it is not as specific as some of the antibodies causing LE...
May 2017: Georgian Medical News
https://www.readbyqxmd.com/read/28628017/-combined-immunotherapy-of-reconditional-chronic-non-specific-vulvovaginitis-in-immunocompromised-girls
#10
I Nesterova, S Kovaleva, G Chudilova, L Lomtatidze, V Krutova, I Aslanian, A Tulendinova, V Malinovskaya
Nonspecific chronic vulvovaginitis (CNV) is often a clinical indicator of immune deficiency, especially in young girls. The established violations of the functioning of various parts of the immune system (IS) in this pathology dictate the need to include in the complex of immunomodulatory therapy. The developed program of combined immunotherapy for immunocompromised girls allows to reduce the severity and duration of exacerbation of CNV, their frequency against the background of a significant reduction in the incidence of ARVI...
May 2017: Georgian Medical News
https://www.readbyqxmd.com/read/28628016/-antiretroviral-therapy-and-the-risk-of-liver-fibrosis-progression-in-hiv-hcv-coinfected-patients
#11
M Arystanbekova, I Balmasova, E Malova, R Sepiashvili
The purpose of the study is to determine the nature of the impact of antiretroviral therapy on the development of liver fibrosis in patients coinfected with human immunodeficiency virus (HIV) and hepatitis C virus (HCV), depending on the order of pathogens acquisition. The fact is that the HIV/HCV coinfection is one of the most common pathological conditions worldwide and liver disease is a major cause of death for these patients. We have previously described the phenomenon, according to which the order of viral pathogens acquisition in HIV/HCV coinfected patients has a significant impact on the degree of progression of liver fibrosis...
May 2017: Georgian Medical News
https://www.readbyqxmd.com/read/28628015/latent-tuberculosis-potential-biomarkers-reactivation-of-infection
#12
I Pantsulaia, N Kikodze, T Chikovani
Tuberculosis continues to be one of the most important infectious causes of death worldwide. Despite substantial investments and progress made in expansion of directly observed therapy short course (DOTS) strategy, improved treatment completion rates and inadequate case detection remains a major obstacle for global control of Tuberculosis. The global case detection rate has increased from 28% to 60%. However, it is estimated that approximately 50% of patients with tuberculosis are still not diagnosed or treated appropriately...
May 2017: Georgian Medical News
https://www.readbyqxmd.com/read/28628014/-selection-of-mini-invasive-palliative-decompression-method-in-patients-with-malignant-obstruction-of-biliary-ducts-based-on-the-study-of-biochemical-bile-indexes
#13
M Bykov, R Sepiashvili, V Shchava, S Gobayeva, I Bykov, A Basov
The article gives our own experience in the determination and study of additional laboratory criteria (total lipids, cholesterol, maximum and area chemiluminescence, antioxidant activity) at the local level (in bile) in patients with bile duct obstruction of malignant etiology. Constellation of metabolic disorders allowed to propose an original method for determining the lithogenicity of bile (integral indicator of lithogenicity). The obtained data made it possible to justify the need to assess the degree of metabolic disturbances in bile, on the basis of which it is possible to predict the risk of lithogenesis and the duration of stent operation, which in turn helped optimize the algorithm for choosing the method of bile ducts decompression aimed at preventing early obturation of endoprostheses...
May 2017: Georgian Medical News
https://www.readbyqxmd.com/read/28628013/modulation-of-antitumor-immune-response-in-mouse-prostate-cancer-model
#14
N Mitskevich, T Tsertsvadze, K Mchedlishvili, K Matchavariani, G Guruli
Aim of study - prostate cancer is second most common cancer in men worldwide, and fifth leading cause of death from cancer in men (6.6% of the total men deaths). Unfortunately, once cancer spreads outside of prostate, it becomes incurable. Androgen deprivation can provide some relief, but resistance will develop eventually, and at that time no effective treatment options are left to the patient. Therefore, the search of alternative treatment modalities is paramount. In this article we evaluated the role of epigenetic modifier 5-azacitidine (5-AzaC) and immunomodulator - Lenalidomide and their possible impact on the immune response in the murine prostate cancer model...
May 2017: Georgian Medical News
https://www.readbyqxmd.com/read/28628012/curative-treatment-of-colorectal-cancer-solitary-metastasis-to-liver-subcapsule-by-percutaneous-us-guided-radiofrequency-ablation-using-hydrodissection-case-report
#15
N Paksashvili, T Ninikashvili, T Azrumelashvili, M Mizandari
Case report presents the successful treatment of solitary liver metastasis in a patient with resected colon cancer. A 39-year-old male underwent left hemicolectomy with colostomy formation followed by chemotherapy for a moderately differentiated adenocarcinoma of the colon. Two years later, a liver metastatic lesion was detected. Patient received chemotherapy; the mass remained stable in size, measuring up to 3 cm in diameter. Low-invasive percutaneous curative treatment by Radiofrequency ablation was conducted using hydrodissection by dielectric fluid intraperitoneal introduction for hydrodissection...
May 2017: Georgian Medical News
https://www.readbyqxmd.com/read/28628011/-criteria-for-selection-of-tumor-cells-and-prospects-for-specific-immunotherapy-for-bladder-cancer
#16
T Slavyanskaya, S -Salnikova, R Sepiashvili
Specific antitumor immunotherapy with autologous dendritic cell vaccines is one of the new approaches of modern medicine. For activation of dendritic cells highly immunogenic antigens are used, however optimal antigens in case of bladder cancer (BC) are still not researched. Cancer-testis antigens (CTA) are the most promising target in the context of creation of antitumor vaccines, because they are distinguished by pronounced immunogenicity, they are detected in different types of tumors and have limited pattern of expression in healthy tissues of grown-up organism...
May 2017: Georgian Medical News
https://www.readbyqxmd.com/read/28628010/-the-main-stages-of-the-preparation-of-viable-tumor-cells-of-bladder-cancer-from-isolation-of-the-tumor-material-till-cryopreservation-of-cell-lines
#17
T Slavyanskaya, S -Salnikova
The development of personalized autologous dendritic cell anti-tumor vaccines (PDPW) against bladder cancer (BC) is a relevant issue that covers many aspects required for its standardization. The article presents personal experimental studies related to development of optimal conditions of transportation of biological material; temperature and temporary modes for the storage of the samples; the materials about the optimal method of disaggregation of the biomaterial; there has been shown a comparative analysis of different methods of tumor disaggregation; the selection of nutritious growth mediums and growth factors for urothelial carcinoma cells (UCC), the conditions of cryopreservation of tumor cells for maximum UCC viability, potentially suitable for creating PDPW against BC...
May 2017: Georgian Medical News
https://www.readbyqxmd.com/read/28628009/-immunorehabilitology-a-look-from-the-sources-to-the-future-from-immunotherapy-to-personalized-targeted-immunorehablitation
#18
R Sepiashvili
Development and introduction of modern clinical diagnostic tests (that allow to evaluate the functional system of immune homeostasis) into medical practice, a huge body of evidence on the leading role of the immune system in pathogenesis most acute and chronic diseases and even identification of specific nosological forms of immune-mediated diseases forced the scientists to search and develop new tools and techniques that have therapeutic effects on the impaired immune homeostasis and restore it to the normal state...
May 2017: Georgian Medical News
https://www.readbyqxmd.com/read/28577016/clinical-and-epidemiological-characterization-of-influenza-a-h1n1pdm-and-b-among-hospitalized-children-georgia-season-2010-2011
#19
A Machablishvili, D Tsereteli, Kh Zakhashvili, I Karseladze, P Imnadze
The aim of the study was to describe, analyze and compare clinical and epidemiological characteristics of laboratory confirmed influenza A(H1N1)pdm and B cases in hospitalized children during post pandemic season. Between 1st January and 1st May, 2011 retrospective observational study was conducted in M. Iashvili Children's Central Hospital. From 1028 patients with influenza like illness hospitalized at Children's Hospital 871 specimens were collected and 360 tested positive for influenza: A(H1N1)pdm - 139 and B - 221...
April 2017: Georgian Medical News
https://www.readbyqxmd.com/read/28577015/prospective-observational-cohort-study-of-predictors-of-the-effectiveness-of-pegylated-interferon-in-patients-with-hepatitis-c-in-georgia
#20
T Tsertsvadze, L Sharvadze, D Metreveli, E Ruadze
The main objective of the study was to evaluate the predictive values of virological response at 4th and 12th weeks after treatment initiation on sustained virological response by HCV genotype in patients with hepatitis C in Georgia. Local, non-interventional, prospective, cohort study was conducted in 2011-2016. A cohort of adult peginterferon treatment naïve patients with chronic hepatitis C were observed during the complete active treatment period with PEGASYS®/COPEGUS® and 24 weeks after the end of treatment...
April 2017: Georgian Medical News
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