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Georgian Medical News

А Naurzaliyeva, Т Rakhypbekov
Purpose - to evaluate the methods of payment for medical aid in the medical organizations of the Republic of Kazakhstan. The materials of the study were statistical and financial indicators of the activity of medical organizations of the Republic of Kazakhstan for 2010-2017. The research is based on methods of organizational and economic research: theoretical analysis, economic and statistical analysis. With the implementation of the system of "global budget" at the Regional Oncologic Dispensary main target indicators of the memorandum was reached with the year 2011-2015...
July 2018: Georgian Medical News
V Tolochko, V Adonkinа, D Vakulenko, T Muzyka
analysis of the assortment of homeopathic medicinal (HoM) in the pharmaceutical market of Ukraine in comparison with the market of the Russian Federation, the Republic of Belarus and Kazakhstan for further provision of recommendations on possible scientific and practical directions, expansion of the HoM nomenclature in the Ukrainian pharmaceutical market. The objects of research were State registers of medicines of Ukraine, the Russian Federation, the Republic of Belarus and Kazakhstan as of 01.01.2018. In the process of research, scientific methods of analysis, systematization and generalization, scientific literature were used...
July 2018: Georgian Medical News
I Belenichev, N Gorchakova, A Puzyrenko, S Kovalenko, N Bukhtiayrova
Today we know that NO· and ONOO- are clue pathophysiological factors for progression some ischemic diseases of the central nervous system. So investigation of the antioxidants which will be able to decrease NO· and ONOO- toxicity seems to be very of current interest. The six esters and three amides of 2-(3,4-dihydro-3-oxo-2H-[1,2,4]triazino[4,3-c]quinazolin-4-yl)acetic acid were synthesized for this study, and we showed evidence of antioxidant activity of these new original derivatives. We studied the effect of 2-(3,4-dihydro-3-oxo-2H-[1,2,4]triazino[4,3-c]quinazolin-4-yl)acetic acid derivatives on superoxide dismutase activity under the condition of excessive NO· and ONOO- production...
July 2018: Georgian Medical News
A Goncharova, S Pavlov, M Kumetchko, M Berezniakova, R Yeriomenko
RANKL and osteoprotegerin are the key cytokines of the axis regulating not only bone remodeling but also bone-kidney interrelations. They are connected with adipokines in the regulatory actions. The aim of the article was to investigate the role of the main parts of RANK-RANKL-osteoprotegerin axis and cytokines of additional link of regulatory network - adiponectin and visfatin and the interrelationship of these cytokines in chronic kidney disorder model in rats. Chronic kidney disorder model was created in the rats 12 weeks after intramuscular 50 % glycerol injection-induced acute kidney injury...
July 2018: Georgian Medical News
M Tsereteli, K Sidamonidze, D Tsereteli, L Malania, E Vashakidze
Klebsiella pneumoniae is one of the most frequent cause of health care associated infections. Dissemination of carbapenem-resistant (CR) K. pneumoniae infections significantly trend toward patient morbidity, length of stay and mortality. The aim of this research was to study prevalence and risk-factors of CR K. pneumoniae in Georgia. To identify risk factors for hospital-acquired carbapenem-resistant (CR) K. pneumoniae, from January 1, 2017 through February 28, 2018, an observational case-control study was performed in the ICUs of two tertiary-care hospitals in Tbilisi (High Medical Technology Centre and Ghudushauri National Medical Centre)...
July 2018: Georgian Medical News
N Lisnychuk, Yu Soroka, I Andrijchuk, Z Nebesna, K Volkov
Under development of dimethylhydrazine-induced adenocarcinomatosis of the large intestine in white outbred male rats morphological changes of the structural components of the spleen were studied. It was found, that the progression of experimental carcinogenesis is accompanied by severe violations of the morphological state of all structural components of the spleen, manifested by destructively degenerative changes of the stroma, red and white pulp and significant vascular disorders. The severity of the pathomorphological changes in the spleen increases directly proportionally to the increase of the duration of the oncogenic factor impact...
July 2018: Georgian Medical News
A Dusyk, S Vernygorodskyi, I Golubovsky, A Hryhorenko, O Slobodian
UUnder stress in the development of metabolic disorders, nitric oxide (NO) occupies a significant place. Dependence of the metabolism of NO indicates its important role in the pathogenesis of diseases of the gastrointestinal tract. The aim of the study is to study immunohistochemical changes in the colon after the large bowel resection and the effect of stress and correction of thiatriazoline. The experiment was performed on 86 male rats. After considering the results of our examination, a long-term exposure to stress of the experimental animals leads to a significant increase of the inducible expression of NO - synthase fractions (iNOs) in the cells of the mucous membrane of the large bowel in the zone of anastomosis...
July 2018: Georgian Medical News
M Gvishiani, L Gabunia, T Makharadze, N Gongadze
Nicorandil is an antianginal agent with a dual mechanism of action. It belongs to ATP-senitive potassium channel openers which has the beneficial effect in angina pectoris, playing an significant role in the dilation of arteries, veins and coronary artery. It leads to the relaxation of vascular smooth muscle and causes vasodilatation of major epicardial vessels. This effect is crucial for reducing risks of further damage in cases when percutaneous coronary intervention (PCI) is necessary. Relevant new studies concluded that Nicorandil has antiarrhythmic and cardioprotective effects by improving reperfusion, ultimately leading to a reduction in microvascular damage caused by PCI...
July 2018: Georgian Medical News
Zh Burkitbaev, S Abdrakhmanova, D Imashpayev, Y Uteuliyev, A Myrzagulova, A Saktapov
The HLA alleles in the Kazakhstan genofund and in the global genofund were compared. The study was carried out on 2283 Kazakhstan donors, 4 566 antigens by five locuses A, B, C, DRB1, DQB1. Comparison with the global HLA alleles was carried out using open internet resource created by the Royal Liverpool University Hospital. The database included information on 8 locuses (A, B, C, DRB1, DPA1, DPB1, DQA1, DQB1), collected in different programs for HLA genofund studies (anthropological research, blood and bone marrow donorship, HLA-associated diseases, etc...
July 2018: Georgian Medical News
K Yurko, V Kozko, A Solomennik, O Bondar, A Sokhan, A Gavrylov
For the first time it was conducted complex research of metabolic disorders in patients co-infected with HIV/HCV and was shown that they are characterized by disturbances of mineral, lipid and carbohydrate metabolism types. It was established significantly higher values of indicators of mineral, lipid and carbohydrate metabolism types in patients co-infected with HIV/HCV compared with patients with chronic hepatitis C and HIV-infected persons. In patients co-infected HIV/HCV appears significantly more frequent the polymorphism Asp299Gly of the gene TLR4 (χ2 = 4,5; p<0,05) when compared with healthy donors, which plays a significant role in the development of metabolic disorders, such correlation is confirmed by those relationships: a strong direct relationship between the polymorphism Asp299Gly of TLR4 gene and the content of insulin (r = 0,66; p<0,001), insulin resistance (r=0,66; p<0,001), the absolute number of CD45+ of T-lymphocytes (r=0 45; p<0,001); a moderate direct relationship with the content of TNF-α (r=0,32; p<0,05), CRP (r=0,34; p<0,05), the absolute number of CD3+ of T-lymphocytes (r=0,34; p<0,05), the content of triglyceride (r=0,39; p<0,02), moderate inverse relationship with the zinc content (r = -0,34; p<0,05 ), the relative number of CD4 +,% (r = -0,32; p<0,05)...
July 2018: Georgian Medical News
I Nozadze, N Tsiklauri, G Gurtskaia, M Tsagareli
Pruritus or itch is defined as the sensation that causes the desire to scratch, and it can be induced by mechanical, thermal and chemical stimuli. Persistent itch accompanying diseases of the skin and other organs can significantly impair the quality of life. There is a growing body of evidence implicating abnormal transient receptor potential (TRP) channel function, as a product of excessive or deficient channel activity, in pathological skin conditions such as pruritus and dermatitis. These data supports the notion that non-histaminergic itch mediators require the activation of TRPA1 channel that has previously been implicated in pain and thermal sensation...
July 2018: Georgian Medical News
M Tusupbekova, N Abatov, K Abugaliev, I Alberton, A Abatova, E Asamidanov, I Musabekov
To this day, limiting the amount of sampling of donor tissue and organs, tissue rejection issues and numerous possible complications remain unresolved problems and are an actual problem of practical urology. This provision indicates the existence of a need to find alternative methods for solving this problem. The aim of the study was to study and compare the morphometric values of various types of implants with the tissue of the kidneys of rats in the early periods. The object of a comparative experimental study was decellularized bovine - derived tissue and a macroporous partially absorbable light UltraPro mesh...
July 2018: Georgian Medical News
I Bagmut, I Kolisnyk, A Titkova, T Petrenko, S Filipchenko
The aim of the research was to determine in the experiment the content of catecholamines in serum of rats exposed to sodium fluoride. The studies were conducted on adult Wistar rats, subjected to oral exposure by means of a probe with aqueous solutions of sodium fluoride (SF) once daily, for 60 days at doses of 1/10, 1/100 and 1/1000 DL50, which correspondingly amounts to 20 mg/kg, 2 mg/kg and 0.2 mg/kg of body weight. Toxification of rats at a dose of 1/100 DL50 for 60 days and at a dose of 1/10 DL50 for 50 days was accompanied by an increase in blood levels of norepinephrine and epinephrine, indicating the hyperactivation of the mediator and hormonal parts of the sympathoadrenal system, and tension of the protective and adaptive reactions of the organism...
July 2018: Georgian Medical News
N Tsagareli, N Tsiklauri, I Kvachadze, M Tsagareli
Pain is characterized as a complex experience, dependent not only on the regulation of nociceptive sensory systems but also on the activation of mechanisms that control emotional processes in limbic brain areas. Non-opioid, non-steroidal anti-inflammatory drugs (NSAIDs) are the most widely used analgesics in the treatment of not-severe pain. We have recently shown that repeated doses result in tolerance to these drugs like opioids. Here we investigated the central brain mechanisms of non-opioid induced antinociception in the non-acute pain models of rats, such as the 'formalin test' and a relation between administration of NSAIDs in the limbic brain area, - the anterior cingulated cortex (ACC), - and the endocannabinoid system...
July 2018: Georgian Medical News
Z Chkhaidze, O Shengelia, O Pilishvili, N Khodeli
In a wide range of acute, debatable problems of transplantology, the problem of donation should be highlighted. It includes the selection and management of the donors, ethical and religious aspects and issues on the prevention, treatment and rehabilitation of the organ before its transplantation. Among the many methods of organ preservation, in the last decade, machine perfusion methods are on the forefront. They are designed to minimize or repair the ischemic-reperfusion damages in tissues and cells. This became possible in conditions of technical progress and the introduction of artificial circulation systems that provide adequate tissue microcirculation in non-heart-beating donors...
July 2018: Georgian Medical News
N Bukia, M Butskhrikidze, L Machavariani, G Kekelia, M Svanidze
Seizure is a clinical manifestation of a hyperexcitable neuronal network, in which, the electrical balance underlying the normal neuronal activity is altered pathologically-excitation (Glutamatergic activity) predominates over inhibition (GABAergic activity). Arresting of seizure activity is carried out by restoration of neurotransmitter balance. This process has a direct relation with ion channel permeability in cell and ion transmembrane movement. Low frequency EMS may have a neurostimulating and neuromodulating effect that is based on electromagnetic induction of electric field in the brain...
July 2018: Georgian Medical News
U Jamedinova
Aim of the study was the analysis of risk factors for the birth of premature infants in the city of Semey, Kazakhstan. We conducted a retrospective cohort study of maternal risk factors for the birth of children prematurely. Prematurely born are children born alive at the time of 37 full weeks of pregnancy. The study included live births born between 2012 and 2015 in the Perinatal Center of the City of Semey. We analyzed the katras of hospitalized sick mothers and their children. A total of 722 children were included in the study, of which 358 were premature babies and 364 full-term infants...
July 2018: Georgian Medical News
T Mikeladze, L Zhorzholiani, L Saginadze, G Arveladze, I Sulaberidze
The study was aiming at investigation of Asthma Predictive Index (API) and predictive value of quantitative changes in nitric/nitrogen oxide (NO) in children with recurrent wheezing of different phenotypes. An observing cross-sectional clinical study where 120 patients 5 to 7 years of ages with wheezing syndrome were involved has been conducted. In the group of patients with multifactorial wheezing, 77%-positive results revealed in 65% of patients indicated to high probability of asthma formation. 59%-positive response to the API index prevailed in patients with episodic wheezing (28%)...
July 2018: Georgian Medical News
T Sorokman, S Sokolnyk, O Popelyuk, O Makarova, T Kopchuk
The most common cause of fever in case of anomalies of the urinary system is pyelonephritis (PN). Despite the fact that an intensive search for informative clinical and laboratory markers of PN in children is being conducted in recent years, this problem remains unresolved. Objective - to examine the content of organ-specific enzymes (neutral α-glucosidase (NAG), L-alanine aminopeptidase (AAP), γ-glutamyltranspeptidase (GGTP) in urine and galectin 3 (Gal -3), C-reactive protein (CPR) in blood serum. A prospective, comprehensive clinical and laboratory-instrumental examination was performed in 75 children under the age of 1...
July 2018: Georgian Medical News
L Lytvynets
The aim of investigation was to learn cytogenetic karyotype characteristics of children with asthma, with varying degrees of control in order to find markers of disease severity. The study involved 82 children aged 6 to 18 years, patients with asthma who were treated in Allergic Department of Regional Pediatric Hospital of Ivano-Frankivsk. Regarding the level of controlled asthma as a result of the application of test control asthma (GINA, 2011) children were distributed as follows: - 22 (30.6%) with controlled (CBA), 24 (33...
July 2018: Georgian Medical News
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