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Korean Journal of Pediatrics

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https://www.readbyqxmd.com/read/30404430/particulate-matter-and-childhood-allergic-diseases
#1
Song-I Yang
Particulate matter (PM) is a ubiquitous air pollutant that is a growing public health concern. Previous studies have suggested that PM is associated with asthma development and exacerbation of asthma symptoms. Although several studies have suggested increased risks of atopic dermatitis, allergic rhinitis, and allergic sensitization in relation to PM exposure, the evidence remains inconsistent. The plausible mechanisms underlying these effects are related to oxidative stress, enhancement of sensitization to allergens, inflammatory and immunological responses, and epigenetics...
November 7, 2018: Korean Journal of Pediatrics
https://www.readbyqxmd.com/read/30404429/high-antistreptolysin-o-titer-is-associated-with-coronary-artery-lesions-in-patients-with-kawasaki-disease
#2
Dong Eun Min, Do Hee Kim, Mi Young Han, Sung Ho Cha, Kyung Lim Yoon
Purpose: In Kawasaki disease(KD) patients, coronary artery complications, incomplete and refractory types occur more frequently in patients with streptococcal or other bacterial/viral infections. Recently, we observed a higher incidence of coronary lesions in KD patients with high anti-streptolysin O(ASO) titer. Therefore, we hypothesized that KD patients diagnosed with concurrent streptococcal infection have poor prognosis, with respect to treatment response and development of coronary artery lesions...
November 7, 2018: Korean Journal of Pediatrics
https://www.readbyqxmd.com/read/30404428/renal-replacement-therapy-in-neonates-with-an-inborn-error-of-metabolism
#3
Heeyeon Cho
Hyperammonemia can caused by several different genetic inborn errors of metabolism including urea cycle defects, organic acidemias, fatty acid oxidation defects, and certain disorders of amino acid metabolism. High levels of ammonia are extremely neurotoxic, leading to astrocyte swelling, brain edema, coma, severe disability, and even death. Thus, emergency treatment for hyperammonemia must begin before a precise diagnosis is established. In neonates with hyperammonemia caused by an inborn error of metabolism, a few studies have suggested that peritoneal dialysis, intermittent hemodialysis, and continuous renal replacement therapy are effective modalities for decreasing plasma level of ammonia...
November 7, 2018: Korean Journal of Pediatrics
https://www.readbyqxmd.com/read/30376706/drug-eruption-by-antihistamine-mistaken-for-chronic-urticaria-in-a-child
#4
Gun Moo Lee, Shou-Yu Chu, Sung Yeon Kang, Hyo-Bin Kim, Jin Sung Park, Ja Kyoung Kim
Although rare, antihistamines can casue adverse effects, including drug-induced eruptions or anaphylaxis. A 4-year-old child visited the pediatric department of a hospital for skin eruptions after administration of antihistamines, (e.g., ucerax® (hydroxyzine) or leptizine® (levocetirizine), for cholinergic rashes; he did not have pruritus. Skin prick, intradermal, and drug provocation tests were performed to determine the relationship between the antihistamines and eruptions. Levocetirizine induced wheals in the skin prick test and a rash in the oral drug provocation test...
October 30, 2018: Korean Journal of Pediatrics
https://www.readbyqxmd.com/read/30376707/reninoma-a-rare-cause-of-curable-hypertension
#5
Ji Hye Kim, Ji Hyun Kim, Myung Hyun Cho, Eujin Park, Hye Sun Hyun, Yo Han Ahn, Hee Gyung Kang, Kyung Chul Moon, Il-Soo Ha, Hae Il Cheong
Refractory hypertension in children is often secondary hypertension, which is potentially curable. Reninoma, a renin-secreting juxtaglomerular cell tumor, is a rare cause of severe hypertension, usually diagnosed in adolescents and young adults. Surgical resection of the tumor completely cures hypertension. The typical clinical presentation includes hypokalemia, metabolic alkalosis, and features secondary to the activation of the renin-angiotensin system without renal artery stenosis. We report a case of reninoma in a female adolescent with a typical clinical presentation, in whom surgical removal of the tumor completely cured hypertension...
October 29, 2018: Korean Journal of Pediatrics
https://www.readbyqxmd.com/read/30360034/the-improvement-of-right-ventricular-function-after-adenotonsillectomy-in-children-with-obstructive-sleep-apnea
#6
Dong Yeop Kim, Kyung Ok Ko, Jae Woo Lim, Jung Min Yoon, Young Hwa Song, Eun Jeong Cheon
Purpose: Adenotonsillar hypertrophy (ATH) that causes upper airway obstruction might lead to chronic hypoxemic pulmonary vasoconstriction and right ventricular (RV) dysfunction. We aimed to evaluate whether adenotonsillectomy (T&A) in children suffering from obstructive sleep apnea (OSA) due to severe ATH could improve RV function. Methods: Thirty-seven children (boy/girl:21/16, mean age: 9.52±2.20years), who underwent T&A forsleep apnea due to ATH, were included...
October 26, 2018: Korean Journal of Pediatrics
https://www.readbyqxmd.com/read/30360038/the-change-of-qrs-duration-after-pulmonary-valve-replacement-in-patients-with-repaired-tetralogy-of-fallot-and-pulmonary-regurgitation
#7
Yuni Yun, Yeo Hyang Kim, Jung Eun Kwon
Purpose: The aim of this study was to analyze the change of QRS duration and cardiothoracic ratio (CTR) after pulmonary valve replacement (PVR) in patients with tetralogy of Fallot (TOF). Methods: Children and adolescent who previously underwent total correction for TOF (n 67; median age 16 years) and required elective PVR for pulmonary regurgitation (PR) and/or right ventricular out tract obstruction (RVOTO) were included. The QRS duration and CTR were measured pre-operatively and post-operatively, and the post-operative changes were calculated...
October 24, 2018: Korean Journal of Pediatrics
https://www.readbyqxmd.com/read/30360037/association-between-vitamin-d-level-at-birth-and-respiratory-morbidities-in-very-low-birth-weight-infants
#8
Ian Kim, Sung Shin Kim, Jee In Song, Seock Hwa Yoon, Ga Young Park, Yong-Wha Lee
Purpose: This study aimed to evaluate vitamin D status at birth in very-low-birth-weight infants (VLBWIs; <1500 g) and to determine the association between vitamin D level and respiratory morbidities. Methods: A retrospective study was conducted at Soonchunhyang University Bucheon Hospital from November 2013 to November 2017. We collected blood samples and data about respiratory morbidities from 230 VLBWIs on the first day of life. Patients who were (1) transferred to other hospitals (n=19); (2) died before 36 weeks' gestational age (n=18); or (3) whose blood samples were not collected immediately after birth (n=5) were excluded...
October 24, 2018: Korean Journal of Pediatrics
https://www.readbyqxmd.com/read/30360036/changes-of-bax-bcl-2-chemokine-receptor-2-monocyte-chemoattractant-protein-1-and-transforming-growth-factor-%C3%AE-1-genes-in-the-left-ventricle-of-spontaneously-hypertensive-rat-after-losartan-treatment
#9
Hyeryon Lee, Kwan Chang Kim, Young Mi Hong
Purpose: Increased level of apoptosis has recently been found in the hypertrophied left ventricle of spontaneously hypertensive rats (SHR). Although the available evidence suggests that apoptosis can be induced in cardiac cells by a variety of insults including pressure overload, cardiac apoptosis seems to occur in adult SHR from an exaggerated local production of angiotensin. Changes in gene expressions of Bcl associated X (Bax), Bcl-2, chemokine receptor (CCR)-2, monocyte chemoattractant protein (MCP)-1, transforming growth factor (TGF)-β1, protein kinase RNA-like ER kinase (PERK), connexin 43 protein, and mRNA levels of kallikrein have been investigated to explore the effects of losartan on SHR model...
October 24, 2018: Korean Journal of Pediatrics
https://www.readbyqxmd.com/read/30360035/iron-status-in-small-for-gestational-age-and-appropriate-for-gestational-age-infants-at-birth
#10
Hyeon A Kim, Sook-Hyun Park, Eun Joo Lee
Purpose: This study compared the iron status between small for gestational age (SGA) and appropriate for gestational age (AGA) infants at birth. Methods: Clinical data of 904 newborn infants admitted to the neonatal intensive care unit were reviewed. Infants' blood samples were taken within 24 hours after birth. Serum ferritin measurements were used as a marker of total iron status. Results: A total 115 SGA (GA 36.5 ± 2.9 weeks, birth weight (BW) 1,975 ± 594...
October 24, 2018: Korean Journal of Pediatrics
https://www.readbyqxmd.com/read/30360041/respiratory-syncytial-virus-associated-seizures-in-korean-children-during-2011-01-2016-12
#11
Teahyen Cha, Young Jin Choi, Jae-Won Oh, Chang-Ryul Kim, Dong Woo Park, In Joon Seol, Jin-Hwa Moon
Purpose: Respiratory syncytial virus (RSV) infection can cause various neurological complications. This study aimed to investigate the RSV-associated neurologic manifestations that are presented with seizures. Methods: We retrospectively reviewed the medical records of patients younger than 15 years who had laboratory-confirmed RSV infections and seizures from January 2011 to December 2016 in a regional hospital in South Korea. Results: During the six years, 1,193 patients who had laboratory-confirmed RSV infection were identified...
October 23, 2018: Korean Journal of Pediatrics
https://www.readbyqxmd.com/read/30360040/acute-kidney-injury-and-continuous-renal-replacement-therapy-in-children-what-pediatricians-need-to-know
#12
Myung Hyun Cho, Hee Gyung Kang
Acute kidney injury (AKI) is abrupt deterioration of renal function, and its diagnosis relies upon creatinine measurements and urine output. AKI is associated with higher morbidity and mortality, and is a risk factor of development of chronic kidney disease. There is no proven medication for AKI. Therefore prevention and early detection are important. Physicians need to be aware of the risk factors for AKI, and monitor renal function in high risk patients. AKI management includes optimization of volume status and renal perfusion, avoidance of nephrotoxic agents, and sufficient nutritional support...
October 23, 2018: Korean Journal of Pediatrics
https://www.readbyqxmd.com/read/30360039/clinical-and-molecular-characterization-of-korean-children-with-infantile-and-late-onset-pompe-disease-10-years-of-experience-with-enzyme-replacement-therapy-at-a-single-center
#13
Min-Sun Kim, Ari Song, Minji Im, June Huh, I-Seok Kang, Jinyoung Song, Aram Yang, Jinsup Kim, Eun-Kyung Kwon, Eu-Jin Choi, Sun-Ju Han, Hyung-Doo Park, Sung Yoon Cho, Dong-Kyu Jin
Purpose: Pompe disease (PD) is an autosomal recessive disorder caused by a deficiency of acid alpha-glucosidase resulting from pathogenic GAA variants. The present study described clinical features, genotypes, changes before and after enzyme replacement therapy (ERT), and long-term outcomes in patients with infantile-onset PD (IOPD) and late-onset PD (LOPD) in one tertiary medical center. Methods: Five Korean patients (two males and three females) diagnosed with PD between 2002 and 2013 at Samsung Medical Center in Seoul, Republic of Korea...
October 23, 2018: Korean Journal of Pediatrics
https://www.readbyqxmd.com/read/30304894/diagnostic-value-of-eosinopenia-and-neutrophil-to-lymphocyte-ratio-on-early-onset-neonatal-sepsis
#14
Rocky Wilar
Purpose: To determine the diagnostic value of eosinopenia and neutrophil to lymphocyte ratio (NLR) for diagnosing Early Onset Neonatal Sepsis (EONS). Methods: This is a cross sectional study that conducted in Neonatology Subdivision of Child Health Department of R.D. Kandou General Hospital Manado from July to October 2017. Samples were obtained from all neonates that were met the inclusion criteria as having EONS. Datas were encoded using logistic regression analysis, biserial point correlation, chi square, and ROC curve with p value <0...
October 8, 2018: Korean Journal of Pediatrics
https://www.readbyqxmd.com/read/30304897/changes-in-the-thyroid-hormone-profiles-in-children-with-nephrotic-syndrome
#15
Sun Hee Jung, Jeong Eun Lee, Woo Yeong Chung
Purpose: We compared thyroid hormone profiles in children with nephrotic syndrome (NS) at nephrotic phase and after remission. Methods: This study included thirty-one pediatric NS patients. Thyroid hormone profiles consist of serum T3, T4, TSH and free T4. Results: Of the 31 patients, 16 (51.6%) showed abnormal findings in their thyroid hormone profiles: six, overt hypothyroidism; eight, subclinical hypothyroidism, and two, low T3 syndrome...
October 4, 2018: Korean Journal of Pediatrics
https://www.readbyqxmd.com/read/30304896/rapidly-growing-pediatric-trampoline-related-injuries-in-korea-a-10-year-single-center-retrospective-study
#16
Min Jeng Cho, Jihoon Kim, Sung Jeep Kim, Kyu Hyouck Kyoung, Min Ae Keum, Sung Kyun Park
Purpose: Several published policy statements have warned for risk of trampoline and have recommended safety guideline. However, few studies have focused on trampoline-related injuries in Korea. The aim of this study was to assess the incidence and characteristics of pediatric trampoline-related injuries presenting to our hospital. Methods: We retrospectively reviewed the medical record of children <16 years old with trampoline-related injuries who visited our emergency department from 2008 to 2017...
October 4, 2018: Korean Journal of Pediatrics
https://www.readbyqxmd.com/read/30304899/dorsal-midline-cutaneous-stigmata-associated-with-occult-spinal-dysraphism-in-pediatric-patients
#17
Hyun Jung Sung, Hyun-Seung Lee
Purpose: To investigate the prevalence of occult spinal dysraphism (OSD) and subsequent neurosurgery in pediatric patients with isolated or combined dorsal midline cutaneous stigmata with or without other congenital malformations. Methods: We undertook a retrospective review of patients who had undergone sonography or magnetic resonance imaging (MRI) evaluation for OSD because of suspicious dorsal midline cutaneous stigmata (defined as presumed markers for OSD) between January 2012 and June 2017...
October 1, 2018: Korean Journal of Pediatrics
https://www.readbyqxmd.com/read/30304898/lymphocyte-monocyte-ratio-at-day-14-of-first-cisplatin-doxorubicin-chemotherapy-is-associated-with-treatment-outcome-of-pediatric-patients-with-localized-osteosarcoma
#18
Jun Ah Lee, Hea Lin Oh, Dong Ho Kim, Jung Sub Lim
Purpose: We aimed to determine the prognostic significance of lymphocyte counts and lymphocyte-monocyte ratio (LMR) in pediatric patients with osteosarcoma. Methods: We retrospectively reviewed the medical records of 27 pediatric patients with localized extremity osteosarcoma treated at Korea Cancer Center Hospital between May 2002 and March 2016. Pretreatment and day 14 of first cisplatin-doxorubicin chemotherapy leukocyte counts and LMR (LMR14) were evaluated...
October 1, 2018: Korean Journal of Pediatrics
https://www.readbyqxmd.com/read/30304900/clinical-features-and-prognostic-factors-of-early-onset-sepsis-a-7-5-year-experience-in-one-neonatal-intensive-care-unit
#19
Se Jin Kim, Ga Eun Kim, Jae Hyun Park, Sang Lak Lee, Chun Soo Kim
Purpose: This study was undertaken to investigate the clinical features and prognostic factors of early-onset sepsis (EOS) in neonatal intensive care unit (NICU) patients. Methods: A retrospective analysis of the medical records was conducted in a NICU of a university hospital over a 7.5-year period (Jan 2010-Jun 2017). Results: During the study period, there were 45 (1.2%) episodes of EOS in 3,862 infants. The most common pathogen responsible for EOS was Streptococcus group B (GBS) in 10 cases (22...
September 27, 2018: Korean Journal of Pediatrics
https://www.readbyqxmd.com/read/30304901/genotype-phenotype-correlations-in-pediatric-patients-with-myotonic-dystrophy-type-1
#20
Hyeong Jung Kim, Ji-Hoon Na, Young-Mock Lee
Purpose: Myotonic dystrophy (also known as dystrophia myotonica; DM) is an autosomal dominant disorder with two genetically distinct forms. DM Type 1 (DM1) is the more common form, and is caused by abnormal expansion of CTG repeat in the DM protein kinase (DMPK) gene. Our study aimed to determine whether age of onset is correlated with CTG-repeat length in a pediatric patient population having DM1. Methods: We retrospectively identified 30 pediatric patients with DM1 that underwent DMPK testing, 17 of which had sufficient clinical data...
September 23, 2018: Korean Journal of Pediatrics
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