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Evidence-based Complementary and Alternative Medicine: ECAM

Soukaïna El-Guendouz, Smail Aazza, Badiaa Lyoussi, Vassya Bankova, Milena Popova, Luís Neto, Maria Leonor Faleiro, Maria da Graça Miguel
This study was performed to evaluate the total phenols, flavonoids, and antioxidant activities of twenty-four propolis samples from different regions of Morocco. In addition, two samples were screened regarding the antibacterial effect against four Staphylococcus aureus strains. Gas chromatography coupled to mass spectra (GC-MS) analysis was done for propolis samples used in antibacterial tests. The minimum inhibitory and minimum bactericidal concentration (MIC, MBC) were determined. The potential to acquire the resistance after sequential exposure of bacterial strains and the impact of adaptation to propolis on virulence using the Galleria mellonella were evaluated...
2018: Evidence-based Complementary and Alternative Medicine: ECAM
Li-Mei Lin, Su-Hui Xiong, Ling-Jia Zhao, Jie Tang, Zhi-Min Zhang, Ya-Mei Li, Tao Zheng, Bo-Hou Xia
In this study, optimization of enzyme-assisted extraction, purification, characterization, and its bioactivities of polysaccharides from Hedyotis corymbosa (HCP) was investigated. It was found that the optimum extraction conditions were 3% of enzyme concentration ( X 1 ), 30 of liquid-to-solid ratio ( X 2 ), 56°C of extraction temperature ( X 3 ), 200W of ultrasonic power ( X 4 ), 10 min of extraction time (X 5 ), and 5 of pH value ( X 6 ). Under optimum conditions, the experimental yield (4.10 ± 0.16%) was closed to the predicted value (4...
2018: Evidence-based Complementary and Alternative Medicine: ECAM
Nan Xiao, Hao Chen, Shi-Yong He, Chong-Xiang Xue, Hua Sui, Jing Chen, Jia-Lin Qu, Li-Na Liang, Lin Zhang
Objective. In China, the method of clearing heat and removing dampness medicine of Chinese traditional medicine has been widely used on gout. However, the clinical effects are various and not summarized systematically. Methods. In this study, a large number of randomized controlled clinical trials were reviewed and analyzed and the clinical efficacy and adverse reactions of traditional Chinese medicine with clearing heat and removing dampness effects for the treatment of gout were systematically evaluated. A comprehensive search of databases including pubMed, China National Knowledge Infrastructure (CNKI), China Science and Technology Journal Database, Wanfang Data, and SinoMed was performed...
2018: Evidence-based Complementary and Alternative Medicine: ECAM
Dandan Zhou, Bo Hu, Shan He, Xiaogang Li, Hui Gong, Feng Li, Qiang Wang
Background: Gastrointestinal functional recovery is an important factor affecting postoperative outcome. The aim of this study was to evaluate the effect of transcutaneous electrical acupoint stimulation (TEAS) on gastrointestinal function in women undergoing cesarean section. Methods: 150 pregnant women undergoing cesarean section were randomly allocated into TEAS, nonacupoint stimulation (sham group), and no stimulation (control group). The primary outcome was indications of gastrointestinal functional recovery and the secondary outcomes included time to first mobilization, postoperative hospital stay, daily living activities at one week after surgery, postoperative side-effects, and serum levels of gastroenterological hormones...
2018: Evidence-based Complementary and Alternative Medicine: ECAM
Bingjin Ou, Wei Tao, Songbai Yang, Jiateng Feng, Jinfeng Wang, Tong Yang, Hanyu Wu, Yaguang Huang, Lingjing Tan, Weifeng Huang, Zhitao Feng, Zhigang Mei
Geum japonicum Thunb. var. chinense (GJ) is a type of wild vegetable found in China and other Asian countries; it has been reported that its extracts possess a neuroprotective effect against cerebral ischemia reperfusion (CIR) injury. The aim of this study is to explore the effect GJ extracts on transient focal CIR injury and neurons apoptosis and to clarify its possible underlying mechanisms in vivo . Our results indicated that pretreatment with GJ extracts significantly ameliorated the infarct volume, decreased neurological deficits, lessened neural cells apoptosis, downregulated GFAP activity level, and increased surviving neurons...
2018: Evidence-based Complementary and Alternative Medicine: ECAM
Bin Liu, Danping Fan, Wen Sun, Kang Zheng, Guoming Pang, Xiaojuan He, Cheng Xiao, Cheng Lu
The potential toxicity of herbal drugs, particularly drug-induced liver injury (DILI), has received extensive attention as the use of Chinese herbal medicine has rapidly increased globally. As a classic Chinese patent medicine, Zhuang Gu Guan Jie Wan (ZGGJW) has been brought into focus recently because of its satisfactory therapeutic effects on osteoarthritis (OA) as well as its unanticipated side effects. This study aimed to decipher the puzzling phenomenon of liver injury developing in response to ZGGJW that varies by the subtype of OA...
2018: Evidence-based Complementary and Alternative Medicine: ECAM
Sung-Jin Kim, Yeon-Cheol Park, Yong-Hyeon Baek, Byung-Kwan Seo
Wilting disorder is an abnormal condition characterized by weakness and paralysis of the upper and lower extremities. Pathogenesis and treatment target of the disorder are unclear; hence, allopathic treatment is generally used to relieve the symptoms. To investigate the treatment mechanism and effect of Traditional Korean Medicine (TKM) in patients with wilting disorder, we reviewed in vivo studies that focused on the effect of TKM on the main symptoms of wilting disorder and treatment of the diseases that can cause these symptoms...
2018: Evidence-based Complementary and Alternative Medicine: ECAM
Karla S Martinez-Elizalde, Marco A Rodriguez-Monroy, Cesar M Flores, Luis B Hernandez-Portilla, Elizabeth Barbosa-Cabrera, Ma Margarita Canales-Martinez
In the Valley of Tehuacan-Cuicatlan, Cyrtocarpa procera and Bursera morelensis are located and are used in traditional medicine. In this research, several biological properties were evaluated. The methanol extracts of C. procera (MeCp) and B. morelensis (MeBm) were obtained by maceration. The antibacterial activities of the extracts were evaluated by the Kirby-Baüer disc-diffusion method. The wound healing activity was evaluated by histopathological analysis. Both extracts had a bacteriostatic effect in the Staphylococcus aureus (MeCp MIC = 0...
2018: Evidence-based Complementary and Alternative Medicine: ECAM
Sung Hae Chang, Yun-Kyung Song, Seong-Su Nah
Background: Gumiganghwal-tang (GMGHT) is a traditional herbal medicine consisting of nine different herbs. GMGHT inhibits the mRNA expression and production of inflammatory cytokines tumor necrosis factor- α (TNF- α ), interleukin-6 (IL-6), and TNF- β on lipopolysaccharide- (LPS-) stimulated peritoneal macrophages in a dose-dependent manner. It is empirically used for the treatment of inflammatory disease, but there are few reports of clinical trials that investigate its efficacy and safety...
2018: Evidence-based Complementary and Alternative Medicine: ECAM
Daniel Z Matata, Olipa D Ngassapa, Francis Machumi, Mainen J Moshi
Background: Inadequate specialized cancer hospitals and high costs are contributing factors that delay cancer patients from accessing health care services in Tanzania. Consequently, majority of patients are first seen by Traditional Health Practitioners (THPs) before they access specialized services. This study presents ethnomedical information and preliminary evaluation of 25 plant species claimed by THPs in Mkuranga and Same districts of Tanzania on use for treatment of cancer. Literature search and laboratory investigation results are presented to support evaluation...
2018: Evidence-based Complementary and Alternative Medicine: ECAM
Nik Amin Sahid, Firdaus Hayati, Challa Venkata Rao, Rosnelifaizur Ramely, Ikhwan Sani, Andee Dzulkarnaen, Zaidi Zakaria, Syed Hassan, Arman Zahari, Aishath Azna Ali
Background: Snakehead fish ( Channa striatus) is a fresh water fish indigenous to many Asia countries and believed to have medical value. Studies showed that it contains all the essential amino acids and fatty acids able to accelerate wound healing and it has antinociceptive effect. However, little human study has been done to assess the effectiveness of Channa striatus in wound healing. A prospective RCT has been conducted on the effect of Channa striatus spray versus placebo on clean wound to assess its pain control effect and cosmetic outcome...
2018: Evidence-based Complementary and Alternative Medicine: ECAM
Meng-Fei Li, Xiao-Meng Zhou, Xue-Lian Li
Purpose: To evaluate the effect of berberine (BBR) on polycystic ovary syndrome (PCOS) patients with insulin resistance (IR). Methods: PubMed (in English), Medline (in English), Embase (in English), CNKI (in Chinese), WanFang DATA (in Chinese), and VIP (in Chinese) were searched for randomized controlled trials in human beings with the search terms including "polycystic ovary syndrome /PCOS" and "berberine/BBR/Huang liansu (in Chinese)/ Xiao bojian (in Chinese)" till July 2018...
2018: Evidence-based Complementary and Alternative Medicine: ECAM
Hong Li, Andrew Hung, Angela Wei Hong Yang
Chronic prostatitis (CP) is a chronic inflammation in the prostate with unsatisfactory management. Danggui Beimu Kushen Wan (DBKW) is a classic formula developed 1800 years ago for patients with difficult urination and it has been widely utilized for CP in modern days. However, scientific understanding of DBKW on CP has not been systematically reviewed. First, we searched the Encyclopedia of Traditional Chinese Medicine for the etiologies and pathogeneses of CP-like symptoms and DBKW and compared their similarities and differences from traditional Chinese medicine and conventional medicine perspectives...
2018: Evidence-based Complementary and Alternative Medicine: ECAM
Yanmei Jia, Lirong Chen
Objective: To evaluate the hypoglycemic effect of Picris japonica Thunb (Asteraceae) on KK-Ay mice. Methods: The hypoglycemic effect of Picris japonica aqueous extract (PJE) in a spontaneous type 2 diabetic model (KK-Ay mice) was studied in the present research. PJE was administrated at doses of 700 mg/kg and 350 mg/kg (calculated as crude herb) for 14 days and blood glucose, oral glucose tolerance test, plasma insulin level, and blood lipid were evaluated. Meanwhile, Rosiglitazone was used for the positive control...
2018: Evidence-based Complementary and Alternative Medicine: ECAM
Kang Zi Khor, Vuanghao Lim, Emmanuel J Moses, Nozlena Abdul Samad
Moringa oleifera , a fast-growing deciduous tree that is widely cultivated in tropical and subtropical regions of the world, is well known for its abundant uses. The tree is a source of food, shelter, and traditional medicine for many people, especially in developing countries. Many studies have been conducted to evaluate the various claims of traditional medicine practitioners that the moringa tree can improve health and treat various diseases. The tree has a high nutritional profile, especially the nutrient rich leaves...
2018: Evidence-based Complementary and Alternative Medicine: ECAM
Zhizhen Liu, Hongqing Yang, Mozhu Zhang, Jing Cai, Zijie Huang
Objective: Blood stasis (BS) constitution represents a tendency to stagnation and positively associates with the severity of atherosclerosis. In this study, we have identified the interaction effect between BS constitution and atherosclerosis on cognitive impairment in the elderly people. Methods: Eligible elderly people ≥65 years old who attended physical examination in the Mawei community of Fuzhou city during 2015 were enrolled in this study. We explored the characteristics of Traditional Chinese Medicine (TCM) constitution and atherosclerotic factors in the normal and cognitive impairment groups and their interaction effect between participants' Minimental State Examination (MMSE) scores in the elderly people...
2018: Evidence-based Complementary and Alternative Medicine: ECAM
Jingkun Lu, Yuchong Hu, Lechun Wang, Yuewu Wang, Shengsang Na, Jian Wang, Yuhui Shun, Xiaoqin Wang, Peifeng Xue, Pengwei Zhao, Liping Su
GuangZao and RouDouKou ( Fructus Choerospondiatis and Nutmeg , FCN) are one of the most common herb pairs in traditional Mongolian medicine for the treatment of coronary heart disease (CHD). However, evidence for the protective effect of FCN is limited, and its underlying mechanism of action remains unclear. The present study employed a network pharmacology approach to identify the potentially active ingredients and synergistic effects of the herb pair FCN as traditional Mongolian medicine. We predicted the targets of all available FCN ingredients with PharmMapper, SWISS, and SuperPred Server and clustered CHD-related targets from the DrugBank and the OMIM database...
2018: Evidence-based Complementary and Alternative Medicine: ECAM
Janet Alejandra Espejel-Nava, Elisa Vega-Avila, Francisco Alarcon-Aguilar, Alejandra Contreras-Ramos, Guadalupe Díaz-Rosas, Gloria Trejo-Aguilar, Clara Ortega-Camarillo
Catharanthus roseus (L.) G. ( C. roseus ) is a medicinal plant used traditionally for diabetes mellitus control. Several compounds of an alkaloidal nature have been proposed as hypoglycemic principles. However, little attention has been paid to other compounds in this plant that could also participate in this hypoglycemic activity. This study aimed to analyze the hypoglycemic effect of a polyphenolic fraction from C. roseus , as well as its action on insulin secretion and expression in RINm5F cells. Methods ...
2018: Evidence-based Complementary and Alternative Medicine: ECAM
Miri Lee, Hyunju Choi, Kyoung-Sook Kim, Dong-Hyun Kim, Cheorl-Ho Kim, Young-Choon Lee
Our recent report showed that curcumin, polyphenolic compound isolated from the herb Curcuma longa , upregulated the gene expression of human GD3 synthase (hST8Sia I) responsible for ganglioside GD3 synthesis with autophagy induction in human lung adenocarcinoma A549 cells. In this study, on the contrary to this finding, we demonstrated that curcumin downregulated the gene expression of human GM3 synthase (hST3Gal V) catalyzing ganglioside GM3 synthesis with autophagy induction in human colon carcinoma HCT116 cells...
2018: Evidence-based Complementary and Alternative Medicine: ECAM
Andréia Cristina de Oliveira Silva, Daniela Aparecida Biasotto-Gonzalez, Fábio Henrique Monteiro Oliveira, Adriano Oliveira Andrade, Cid André Fidelis de Paula Gomes, Fernanda de Córdoba Lanza, César Ferreira Amorim, Fabiano Politti
Previous studies have reported that visceral disturbances can lead to increased musculoskeletal tension and pain in structures innervated from the corresponding spinal level through viscerosomatic reflexes. We designed a pilot randomised placebo-controlled study using placebo visceral manipulation as the control to evaluate the effect of osteopathic visceral manipulation (OVM) of the stomach and liver on pain, cervical mobility, and electromyographic activity of the upper trapezius (UT) muscle in individuals with nonspecific neck pain (NS-NP) and functional dyspepsia...
2018: Evidence-based Complementary and Alternative Medicine: ECAM
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