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Evidence-based Complementary and Alternative Medicine: ECAM

Bora Tastekin, Aykut Pelit, Sait Polat, Abdullah Tuli, Leman Sencar, Mustafa Muhlis Alparslan, Yusuf Kenan Daglioglu
Aims: The aim of this study was to investigate the effects of pterostilbene (PTS) (trans-3,5-dimethoxy-4'-hydroxystilbene) and resveratrol (RSV) (trans-3,5,4' trihydroxystilbene) applied at different doses for the treatment of streptozotocin- (STZ-) induced diabetic rats. Materials and Methods: At the end of the 5-week experimental period, the right gastrocnemius muscles of the rats were examined biomechanically, while the left ones were examined histologically...
2018: Evidence-based Complementary and Alternative Medicine: ECAM
Elena-Alina Moacă, Claudia Farcaş, Alexandra Ghiţu, Dorina Coricovac, Ramona Popovici, Nela-Loredana Cărăba-Meiţă, Florina Ardelean, Diana Simona Antal, Cristina Dehelean, Ştefana Avram
Melissa officinalis L. has attracted an increased interest in recent years due to its multiple pharmacological effects. This study aimed to compare two M. officinalis ethanolic extracts, obtained from leaves and stems, with regard to their antioxidant activity, total phenolic content, and cytotoxic effects. M. officinalis ethanolic extracts showed a very good antioxidant activity in the DPPH test, correlated with the content in total phenols: higher in the case of M. officinalis from leaves extract (32.76 mg GAE/g) and lower for M...
2018: Evidence-based Complementary and Alternative Medicine: ECAM
Yi Jinn Lillian Chen, Pei-Chi Chou, Chang Lu Hsu, Jeng-Fung Hung, Yang-Chang Wu, Jaung-Geng Lin
Fermented lemon juice displays a variety of important biological activities, including anti-inflammatory and antioxidant capabilities. The aim of the present study is to investigate hepatic-protective effects of no-sugar-added fermented lemon juice (FLJ) for liver inflammation caused by carbon tetrachloride (CCl4 ) in rats. Rats are divided into six groups: H2 O, CCl4 + H2 O, CCl4 + silymarin, and CCl4 plus three different FLJ doses by oral administration, respectively. The results show that the contents of plasma ALT and AST, hepatic lipid peroxidation, splenomegaly, and liver water are reduced significantly in rats under FLJ treatment, and pathological examination of liver fibrosis is improved...
2018: Evidence-based Complementary and Alternative Medicine: ECAM
Li Yu, Weifeng Jin, Xiaohong Li, Yuyan Zhang
The ultraviolet spectrophotometric method is often used for determining the content of glycyrrhizic acid from Chinese herbal medicine Glycyrrhiza glabra . Based on the traditional single variable approach, four extraction parameters of ammonia concentration, ethanol concentration, circumfluence time, and liquid-solid ratio are adopted as the independent extraction variables. In the present work, central composite design of four factors and five levels is applied to design the extraction experiments. Subsequently, the prediction models of response surface methodology, artificial neural networks, and genetic algorithm-artificial neural networks are developed to analyze the obtained experimental data, while the genetic algorithm is utilized to find the optimal extraction parameters for the above well-established models...
2018: Evidence-based Complementary and Alternative Medicine: ECAM
Liang Chen, Dongqing Li, Jun Zhong, Bo Qiu, Xianglei Wu
[This corrects the article DOI: 10.1155/2018/6513049.].
2018: Evidence-based Complementary and Alternative Medicine: ECAM
Peihe Liang, Jia Guo, Shadan Li, Qiunong Guan, Terry Vanderheyden, Alan So, Yuzhuo Wang, Tao Chen, Caigan Du
Low-risk prostate cancer (PCa) does not require immediate treatment, but PCa progression after years of active surveillance will need the treatment. This study was to test the efficacy of immunostimulant Deep Immune (DI) in controlling PCa progression. DI is an extract of eight different medicinal herbs. In vitro activity of DI was determined by phagocytosis activation using flow cytometric analysis of fluorescence-labeled latex bead uptake, expression of immune-modulating 84 genes using PCRarray, and tumor killing using coculturing with immune cells...
2018: Evidence-based Complementary and Alternative Medicine: ECAM
Danielle Gomes Santana, Alan Santos Oliveira, Marília Trindade de Santana Souza, José Thiago do Carmo Santos, Neuza Mariko Aymoto Hassimotto, Ana Mara de Oliveira E Silva, Renata Grespan, Enilton Aparecido Camargo
We evaluated the effect of the hydroethanolic extract of fruits of Vaccinium macrocarpon (HEVm) in a model of acute pancreatitis (AP) in mice. AP was induced by two injections of L-arginine and animals were treated with HEVm (50, 100, and 200 mg/kg, p.o.) or vehicle (saline) every 24 h, starting 1 h after the induction of AP. Phytochemical analysis of the extract and measurement of inflammatory and oxidative stress parameters, as well as abdominal hyperalgesia, were performed. Catechin, epicatechin, rutin, and anthocyanins were identified in HEVm...
2018: Evidence-based Complementary and Alternative Medicine: ECAM
María Laura González, Mariana Belén Joray, Jerónimo Laiolo, María Inés Crespo, Sara María Palacios, Gustavo Miguel Ruiz, María Cecilia Carpinella
Plants are a significant reservoir of cytotoxic agents, including compounds with the ability to interfere with multidrug-resistant (MDR) cells. With the aim of finding promising candidates for chemotherapy, 91 native and naturalized plants collected from the central region of Argentina were screened for their cytotoxic effect toward sensitive and MDR P-glycoprotein (P-gp) overexpressing human leukemia cells by means of MTT assays. The ethanol extracts obtained from Aldama tucumanensis , Ambrosia elatior , Baccharis artemisioides , Baccharis coridifolia , Dimerostemma aspilioides , Gaillardia megapotamica , and Vernonanthura nudiflora presented outstanding antiproliferative activity at 50  μ g/mL, with inhibitory values from 93 to 100%, when tested on the acute lymphoblastic leukemia (ALL) cell line CCRF-CEM and the resistant derivative CEM-ADR5000, while 70-90% inhibition was observed against the chronic myelogenous leukemia (CML) cell K562 and its corresponding resistant subline, Lucena 1...
2018: Evidence-based Complementary and Alternative Medicine: ECAM
Yi-Fan Li, Tie Li, Da-Wei Zhang, Hui Xue, Dong Chen, Chen Li, Fu-Chun Wang
The present study aimed to evaluate the role of the combination treatment of methylprednisolone (MP) and electroacupuncture (EA) in regeneration of nerve fibers and functional recovery in rats with spinal cord injury (SCI). Female Wistar rats were used for an SCI model by using a weight-drop hammer at levels T10 (spinal cord segment corresponding to the 10th thoracic vertebra). Four groups received different treatments for the study: SCI control, MP, MP and EA, and Sham. The growth of nerve fibers was examined by counting fluorescein positive nerve fibers...
2018: Evidence-based Complementary and Alternative Medicine: ECAM
Md Sakib Hossen, Md Maruf Billah Prince, E M Tanvir, M Alamgir Zaman Chowdhury, Md Abdur Rahman, Fahmida Alam, Sudip Paul, Moumoni Saha, Md Yousuf Ali, Nikhil Chandra Bhoumik, Nurul Karim, Siew Hua Gan, Md Ibrahim Khalil
The current study aimed to investigate the ameliorative effects of two types of mushrooms, Ganoderma lucidum (GL) and Auricularia polytricha (AP), against carbofuran- (CF) induced toxicity in rats. Male Wistar rats ( n = 42) were divided into six equal groups. The rats in the negative control group received oral administration of CF at 1 mg/kg with the normal diet for 28 days. The treatment groups received oral administration of ethanolic extract of GL or AP at 100 mg/kg followed by coadministration of CF at 1 mg/kg with the normal diet for the same experimental period, respectively...
2018: Evidence-based Complementary and Alternative Medicine: ECAM
Hye-Yeon Han, Hyung Joon Kim, Seung-Hwa Jeong, Jiyeon Kim, Sung-Hee Jeong, Gyoo Cheon Kim, Dae-Seok Hwang, Uk-Kyu Kim, Mi Heon Ryu
Jaceosidin is a single compound from the Japanese mugwort Artemisia princeps , which is used as a food and a traditional medicinal herb. A. princeps extracts and flavonoid components have been shown to have antihyperglycaemic, antioxidant, and anti-inflammatory properties. Although the anticancer properties of these extracts were recently demonstrated, the related mechanisms have not been characterised. In this study, we investigated the effects of jaceosidin in oral squamous cell carcinoma (OSCC) cells and initially showed selective suppression of proliferation (IC50 = 82...
2018: Evidence-based Complementary and Alternative Medicine: ECAM
Amira Raudhah Abdullah, Hermizi Hapidin, Hasmah Abdullah
Background. Quercus infectoria (QI) is a plant used in traditional medicines in Asia. The plant was reported to contain various active phytochemical compounds that have potential to stimulate bone formation. However, the precise mechanism of the stimulation effect of QI on osteoblast has not been elucidated. The present study was carried out to isolate QI semipurified fractions from aqueous QI extract and to delineate the molecular mechanism of QI semipurified fraction that enhanced bone formation by using hFOB1...
2018: Evidence-based Complementary and Alternative Medicine: ECAM
Tao-Hua Lan, Lu-Lu Zhang, Yong-Hua Wang, Huan-Lin Wu, Dan-Ping Xu
Cardiovascular diseases (CVDs) have been recognized as first killer of human health. The underlying mechanisms of CVDs are extremely complicated and not fully revealed, leading to a challenge for CVDs treatment in modern medicine. Traditional Chinese medicine (TCM) characterized by multiple compounds and targets has shown its marked effects on CVDs therapy. However, system-level understanding of the molecular mechanisms is still ambiguous. In this study, a system pharmacology approach was developed to reveal the underlying molecular mechanisms of a clinically effective herb formula (Wen-Dan Decoction) in treating CVDs...
2018: Evidence-based Complementary and Alternative Medicine: ECAM
Xiting Zhang, Lin Li, Ting Chen, Zuoyan Sun, Weiwei Tang, Shuang Wang, Tianqi Wang, Yi Wang, Han Zhang
Tonic traditional Chinese medicine is widely used in clinical practice and is categorized into four main drugs, namely, Qi-supplementing, Blood-enriching, Yin-nourishing, and Yang-tonifying. Neurotransmitters play a coordinating role in the nervous system, visceral function, and stress response. The excitation or suppression of the central nervous system is closely related to various diseases, such as insomnia, depression, Alzheimer's disease, Parkinson's disease, and perimenopausal syndrome. An increasing amount of evidence shows that Chinese tonic herb and its active ingredients can delay the occurrence and development of these diseases by modulating related neurotransmitters and their receptors, including norepinephrine (NE), serotonin (5-HT), dopamine (DA), acetylcholine (ACh), and γ -aminobutyric acid (GABA)...
2018: Evidence-based Complementary and Alternative Medicine: ECAM
Jeffrey M Greeson, Haley Zarrin, Moria J Smoski, Jeffrey G Brantley, Thomas R Lynch, Daniel M Webber, Martica H Hall, Edward C Suarez, Ruth Q Wolever
Mindfulness-Based Stress Reduction (MBSR) is an 8-week meditation program known to improve anxiety, depression, and psychological well-being. Other health-related effects, such as sleep quality, are less well established, as are the psychological processes associated with therapeutic change. This prospective, observational study ( n = 213) aimed to determine whether perseverative cognition, indicated by rumination and intrusive thoughts, and emotion regulation, measured by avoidance, thought suppression, emotion suppression, and cognitive reappraisal, partly accounted for the hypothesized relationship between changes in mindfulness and two health-related outcomes: sleep quality and stress-related physical symptoms...
2018: Evidence-based Complementary and Alternative Medicine: ECAM
Hye-Sung Park, Jae-Heung Cho, Koh-Woon Kim, Won-Seok Chung, Mi-Yeon Song
Objective: To determine the antiobesity effects of Panax ginseng in animals. Methods: We conducted a systematic search for all controlled trials (up to March 2017) that assessed the antiobesity effects of P. ginseng in animal obesity models in the PubMed, EMBASE, Cochrane library, Web of Science, and Scopus databases. The primary outcome was final body weight measured at the longest follow-up time after administration of the intervention. The secondary outcome was the lipid profile...
2018: Evidence-based Complementary and Alternative Medicine: ECAM
Akhlaq A Farooqui, Tahira Farooqui, Anil Madan, Jolin Hwee-Jing Ong, Wei-Yi Ong
Ayurvedic medicine is a personalized system of traditional medicine native to India and the Indian subcontinent. It is based on a holistic view of treatment which promotes and supports equilibrium in different aspects of human life: the body, mind, and soul. Popular Ayurvedic medicinal plants and formulations that are used to slow down brain aging and enhance memory include Ashwagandha (Withania somnifera) , Turmeric (Curcuma longa) , Brahmi (Bacopa monnieri) , Shankhpushpi ( Convolvulus pluricaulis, Evolvulus alsinoides , and other species), gotu kola (Centella asiatica) , and guggulu ( Commiphora mukul and related species) and a formulation known as Brāhmī Gh ṛ ita, containing Brahmi, Vacā (Acorus calamus) , Ku ṣṭ ha (Saussurea lappa) , Shankhpushpi, and Purāṇa Gh ṛ ita (old clarified butter/old ghee)...
2018: Evidence-based Complementary and Alternative Medicine: ECAM
Xiao-Mei Wang, Jing Gong, Si-Cong Li, Mei Han
Objective: To compare the effectiveness and safety of acupuncture versus intramuscular injection of neostigmine. Methods: Databases including CNKI, VIP, WanFang, SinoMed, PubMed, Cochrane Library, and database were retrieved for relevant literature, with the retrieval deadline being November 2017. Two reviewers independently screened, selected, and extracted data and validated the results. The methodological quality was evaluated with the "Risk of Bias" tool, and the meta-analysis was performed by using the RevMan 5...
2018: Evidence-based Complementary and Alternative Medicine: ECAM
Fei Xu, Jinpei Lin, Wenqiang Cui, Qing Kong, Qiuping Li, Lulu Li, Ying Wei, Jingcheng Dong
Background. Scutellaria baicalensis (SB) is commonly used in traditional Chinese medicine for chronic inflammatory diseases. This study aims to investigate the effects of the early intervention with SB on airway remodeling in a well-established rat model of COPD induced by cigarette smoking. Methods. COPD model in Sprague Dawley (SD) rats were established by exposing them to smoke for 6 days/week, for 12 weeks, 24 weeks, or 36 weeks. Meanwhile, rats were randomly divided into normal control group, model group, Budesonide (BUD) group, and the SB (low, middle, and high) dose groups with 8 rats in each group and 3 stages (12 weeks, 24 weeks, and 36 weeks)...
2018: Evidence-based Complementary and Alternative Medicine: ECAM
Vincenzo Simonetti, Vincenzo Quagliariello, Pierangela Giustetto, Marianno Franzini, Rosario Vincenzo Iaffaioli
[This corrects the article DOI: 10.1155/2017/7414083.].
2018: Evidence-based Complementary and Alternative Medicine: ECAM
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