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Evidence-based Complementary and Alternative Medicine: ECAM

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https://www.readbyqxmd.com/read/29138646/the-characteristics-of-tcm-clinical-trials-a-systematic-review-of-clinicaltrials-gov
#1
REVIEW
Junchao Chen, Jihan Huang, Jordan V Li, Yinghua Lv, Yingchun He, Qingshan Zheng
Objective: The aim of this review is to characterize current status of global TCM clinical trials registered in ClinicalTrials.gov. Methods: We examined all the trials registered within ClinicalTrials.gov up to 25 September 2015, focusing on study interventions to identify TCM-related trials, and extracted 1,270 TCM trials from the data set. Results: Overall, 691 (54.4%) trials were acupuncture, and 454 (35.8%) trials were herbal medicines...
2017: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/29138645/chinese-classical-formula-sijunzi-decoction-and-chronic-atrophic-gastritis-evidence-for-treatment-approach
#2
REVIEW
Danan Gan, Aili Xu, Hongbo Du, Yong'an Ye
Objective: This aim is to evaluate the effect of Sijunzi decoction (SJZD) treating chronic atrophic gastritis (CAG). Methods: We performed searches in seven databases. The randomized controlled trials (RCTs) comparing SJZD with standard medical care or inactive intervention for CAG were enrolled. Combined therapy of SJZD plus conventional therapies compared with conventional therapies alone was also retrieved. The primary outcome included the incidence of gastric cancer and the improvement of atrophy, intestinal metaplasia, and dysplasia based on the gastroscopy and pathology...
2017: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/29138644/acupotomy-therapy-for-chronic-nonspecific-neck-pain-a-systematic-review-and-meta-analysis
#3
REVIEW
Fushui Liu, Fanyuan Zhou, Meimei Zhao, Ting Fang, Mei Chen, Xiaojun Yan
Objective: This review is to assess the efficacy and safety of acupotomy therapy in chronic nonspecific neck pain. Methods: We searched six computerised databases. Randomized controlled trials incorporating acupotomy therapy alone or combined with other conventional treatments for chronic nonspecific neck pain were included. Two reviewers screened each literature and extracted data independently according to Cochrane Reviews' Handbook (5.1). The Cochrane Collaboration's RevMan 5...
2017: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/29138643/interactions-of-desmethoxyyangonin-a-secondary-metabolite-from-renealmia-alpinia-with-human-monoamine-oxidase-a-and-oxidase-b
#4
Narayan D Chaurasiya, Francisco León, Yuanqing Ding, Isabel Gómez-Betancur, Dora Benjumea, Larry A Walker, Stephen J Cutler, Babu L Tekwani
Renealmia alpinia (Zingiberaceae), a medicinal plant of tropical rainforests, is used to treat snakebites and other injuries and also as a febrifuge, analgesic, antiemetic, antiulcer, and anticonvulsant. The dichloromethane extract of R. alpinia leaves showed potent inhibition of human monoamine oxidases- (MAOs-) A and B. Phytochemical studies yielded six known compounds, including pinostrobin 1, 4'-methyl ether sakuranetin 2, sakuranetin 3, pinostrobin chalcone 4, yashabushidiol A 5, and desmethoxyyangonin 6...
2017: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/29104606/astilbin-from-smilax-glabra-roxb-attenuates-inflammatory-responses-in-complete-freund-s-adjuvant-induced-arthritis-rats
#5
Lisha Dong, Jinqiu Zhu, Hongzhi Du, Heng Nong, Xicheng He, Xiaoyu Chen
Astilbin, a flavonoid compound, was isolated from the rhizome of Smilax glabra Roxb. (with red cross-section) grown in Guizhou Province, China. We accessed its effect and potential mechanism on attenuation of the inflammatory response in CFA-induced AA rats. Our results showed that daily oral administration of astilbin at 5.3 mg/kg reduced joint damage in the hind paw of AA rats. Accordingly, astilbin exhibited remarkable inhibitory effects on TNF-α, IL-1β, and IL-6 mRNA expression. Significant decrease of serum cytokine levels of TNF-α, IL-1β, and IL-6 was also observed in astilbin-treated AA rats compared to the vehicle-treated AA rats...
2017: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/29104605/the-antioxidative-antiaging-and-hepatoprotective-effects-of-alkali-extractable-polysaccharides-by-agaricus-bisporus
#6
Shangshang Li, Juan Li, Jianjun Zhang, Wenshuai Wang, Xiuxiu Wang, Huijuan Jing, Zhenzhen Ren, Zheng Gao, Xinling Song, Zhiyuan Gong, Le Jia
The aim of this work was designed to investigate the antioxidant, antiaging, and hepatoprotective effects of alkali-extractable polysaccharides (AlAPS) and their three purified fractions (AlAPS-1, AlAPS-2, and AlAPS-3) from Agaricus bisporus in D-galactose induced aging mice. For in vitro antioxidant analysis, both AlAPS and its fractions exhibited moderate reducing power, Fe(2+)-chelating activities, and potent scavenging activities on hydroxyl and 1,1-diphenyl-2-picrylhydrazyl (DPPH) radicals. The in vivo results demonstrated that the polysaccharides, especially AlAPS-2, showed potential antiaging and hepatoprotective effects by enhancing the antioxidant status, decreasing serum hepatic enzyme activities, and improving the lipid metabolism...
2017: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/29098013/antidepressant-mechanism-research-of-acupuncture-insights-from-a-genome-wide-transcriptome-analysis-of-frontal-cortex-in-rats-with-chronic-restraint-stress
#7
Yu Wang, Huili Jiang, Hong Meng, Jing Li, XinJing Yang, Bingcong Zhao, Yang Sun, Tuya Bao
Major depressive disorder (MDD) is a chronic disease that adversely affects mood and cognition. In this study, we randomly divided the rats into control group (C), model group (M), fluoxetine group (F), and acupuncture group (A), used open-field test to ascertain whether acupuncture affects chronic restraint stress (CRS) induced depression-like behaviors of rats, and explored the antidepressant mechanism of acupuncture at the molecular level of transcriptome in the frontal cortex of CRS rats by RNA-sequencing (RNA-seq)...
2017: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/29085435/the-optimal-cut-off-value-of-blood-stasis-syndrome-score-in-bss-diagnosis-in-korea
#8
Byoung-Kab Kang, Tae-Yong Park, Jeeyoun Jung, Mimi Ko, Myeong Soo Lee, Ju Ah Lee
OBJECTIVE: In the traditional oriental medicine, it is sometimes difficult to diagnose Blood Stasis Syndrome (BSS) in patients, because the diagnosis of BSS is based on the subjective signs and symptoms of patients. This study is aimed at developing the prediction tool of BSS using cut-off value for BSS score. The identification of a cut-off value for BSS score to diagnose BSS would be helpful. METHODS: A total of 887 patients admitted to six traditional Korean medical hospitals in 2013 and three hospitals in 2014...
2017: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/29085434/effect-of-seyoeum-on-obesity-insulin-resistance-and-nonalcoholic-fatty-liver-disease-of-high-fat-diet-fed-c57bl-6-mice
#9
Hyun-Young Na, Mi Hyeon Seol, Mia Kim, Byung-Cheol Lee
BACKGROUND: This study was performed to evaluate the effect of Seyoeum (SYE), a novel herbal meal replacement, on insulin resistance and nonalcoholic fatty liver disease (NAFLD) in obese mice fed with a high-fat diet (HFD). METHODS: SYE contained six kinds of herbal powder such as Coix lacryma-jobi, Oryza sativa, Sesamum indicum, Glycine max, Liriope platyphylla, and Dioscorea batatas. Male C57BL/6 mice were divided into four groups: normal chow (NC), HFD, SYE, and HFD plus SYE (HFD + SYE)...
2017: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/29085433/corrigendum-to-ferulic-acid-induces-th1-responses-by-modulating-the-function-of-dendritic-cells-and-ameliorates-th2-mediated-allergic-airway-inflammation-in-mice
#10
Chen-Chen Lee, Ching-Chiung Wang, Huei-Mei Huang, Chu-Lun Lin, Sy-Jye Leu, Yueh-Lun Lee
[This corrects the article DOI: 10.1155/2015/678487.].
2017: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/29081823/biological-and-phytochemical-investigations-on-caesalpinia-benthamiana-a-plant-traditionally-used-as-antimalarial-in-guinea
#11
Jean Loua, Mohamed Sahar Traore, Aissata Camara, Mamadou Aliou Balde, Louis Maes, Luc Pieters, Aliou Mamadou Balde
Caesalpinia benthamiana is widely used as antimalarial in Guinean traditional medicine. Leaf extracts of the plant were tested for their in vitro antiprotozoal activity against Trypanosoma brucei brucei and T. cruzi and the chloroquine-sensitive Ghana strain of Plasmodium falciparum along with their cytotoxicity on MRC-5 cells. The methanolic extract showed the strongest antiprotozoal activity against P. falciparum (IC50 4 μg/ml), a good activity against T. brucei (IC50 13 μg/ml), and a moderate activity against T...
2017: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/29081822/southeast-asian-medicinal-plants-as-a-potential-source-of-antituberculosis-agent
#12
REVIEW
Shuaibu Babaji Sanusi, Mohd Fadzelly Abu Bakar, Maryati Mohamed, Siti Fatimah Sabran, Muhammad Murtala Mainasara
Despite all of the control strategies, tuberculosis (TB) is still a major cause of death globally and one-third of the world's population is infected with TB. The drugs used for TB treatment have drawbacks of causing adverse side effects and emergence of resistance strains. Plant-derived medicines have since been used in traditional medical system for the treatment of numerous ailments worldwide. There were nine major review publications on antimycobacteria from plants in the last 17 years. However, none is focused on Southeast Asian medicinal plants...
2017: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/29081821/flavonoid-composition-and-biological-activities-of-ethanol-extracts-of-caryocar-coriaceum-wittm-a-native-plant-from-caatinga-biome
#13
Daniela Ribeiro Alves, Selene Maia de Morais, Fernanda Tomiotto-Pellissier, Milena Menegazzo Miranda-Sapla, Fábio Roger Vasconcelos, Isaac Neto Goes da Silva, Halisson Araujo de Sousa, João Paulo Assolini, Ivete Conchon-Costa, Wander Rogério Pavanelli, Francisco das Chagas Oliveira Freire
Caryocar coriaceum fruits, found in Brazilian Cerrado and Caatinga, are commonly used as food and in folk medicine, as anti-inflammatory, bactericide, fungicide, leishmanicide, and nematicide. Due to the biological potential of this plant, this study focuses on the evaluation of antifungal and antileishmanial activities, including anticholinesterase and antioxidant tests, correlating with total phenols and flavonoids content. Peel extracts contain higher yield of phenols and flavonoids as analyzed by spectrophotometric methods...
2017: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/29081820/antihypercholesterolemic-effects-of-fruit-aqueous-extract-of-copernicia-prunifera-miller-h-e-moore-in-mice-diet-induced-hypercholesterolemia
#14
Raquel Teixeira Terceiro Paim, Stephen Rathinaraj Benjamin, Davide Rondina, Márcia Maria Mendes Marques, Daniel de Araújo Viana, Maria Leônia da Costa Gonzaga, Ícaro Gusmão Pinto Vieira, Francisca Noélia Pereira Mendes, Paula Alves Salmito Rodrigues, Maria Izabel Florindo Guedes
The present objective of the investigation is to evaluate the antihypercholesterolemic activity of the aqueous fruit pulp extract (APE) of Copernicia prunifera (Miller) H. E. Moore (Arecaceae family). Various chemical characterization methods like thin layer chromatography, Fourier transform infrared spectroscopy, (1)H and (13)C NMR, and molecular weight by gel permeation chromatography have been employed to characterize the extracted pectin. The present study demonstrated that hypercholesterolemic diet (HD) created hypercholesterolemia, caused significant increases in body weight, total cholesterol, and low-density lipoprotein, and caused decreases in high-density lipoprotein in serum compared with SD group...
2017: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/29081819/cognitive-function-of-artemisia-argyi-h-fermented-by-monascus-purpureus-under-tmt-induced-learning-and-memory-deficits-in-icr-mice
#15
Jin Yong Kang, Du Sang Lee, Seon Kyeong Park, Jeong Su Ha, Jong Min Kim, Gi Jeong Ha, Weon Taek Seo, Ho Jin Heo
The cognitive effect of Artemisia argyi H. under liquid-state fermentation by Monascus purpureus (AAFM), which has cellular antioxidant activity and neuronal cell viability, on trimethyltin- (TMT-) induced learning and memory impairment in Institute of Cancer Research (ICR) mice was confirmed. Tests were conducted to determine the neuroprotective effects against H2O2-induced oxidative stress, and the results showed that AAFM has protective effects through the repression of mitochondrial injury and cellular membrane damage against H2O2-induced neurotoxicity...
2017: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/29081818/curcumin-induces-autophagy-apoptosis-and-cell-cycle-arrest-in-human-pancreatic-cancer-cells
#16
Yaping Zhu, Shurui Bu
OBJECTIVE: Curcumin is an active extract from turmeric. The aim of this study was to identify the underlying mechanism of curcumin on PCa cells and the role of autophagy in this process. METHODS: The inhibitory effect of curcumin on the growth of PANC1 and BxPC3 cell lines was detected by CCK-8 assay. Cell cycle distribution and apoptosis were tested by flow cytometry. Autophagosomes were tested by cell immunofluorescence assay. The protein expression was detected by Western blot...
2017: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/29081817/compound-danshen-dripping-pill-for-treating-nonproliferative-diabetic-retinopathy-a-meta-analysis-of-13-randomized-controlled-trials
#17
REVIEW
Wenjing Huang, Qi Bao, De Jin, Fengmei Lian
OBJECTIVE: We assess the clinical effect of compound Danshen dripping pill (CDDP) for treating diabetic retinopathy (DR). METHODS: Electronic databases were searched from January 2001 to October 2016 to locate randomized controlled trials (RCTs). Efficacy was measured as main outcome and microaneurysms, hemorrhage, exudate, vision, and fundus fluorescein angiography (FFA) were measured as second outcomes. Methodological quality for each study was evaluated, RevMan 5 software was used to assess treatment effects, and GRADE was used to rate quality of evidence...
2017: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/29081816/integrative-medicine-for-postoperative-patients-a-survey-of-korean-medicine-doctors
#18
Sun-Young Moon, Kyung-Min Shin, Jae-Young Shin, O-Jin Kwon, Jun-Hwan Lee
The purpose of this survey was to document the experience of Korean Medicine doctors (KMD) who provided postoperative care to patients through integrative medicine and to understand their opinions about integrative medicine utilization. Three researchers (two with a KMD license) of the Korea Institute of Oriental Medicine conducted the survey. The questionnaire was distributed via e-mail to the 17,041 members of the Association of Korean Medicine in 2015. In total, 487 KMD answered the questionnaires. The majority of respondents worked in a Korean Medicine (KM) clinic, KM hospital, or long-term care hospitals (94...
2017: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/29081815/effects-of-brucine-on-the-opg-rankl-rank-signaling-pathway-in-mda-mb-231-and-mc3t3-e1-cell-coculture-system
#19
Ruixian Wu, Qian Li, Xiaohua Pei, Kefei Hu
The present study examined the effects of brucine on the OPG/RANKL/RANK signaling pathway for exploring the mechanism of brucine suppression of bone metastasis in breast cancer. MDA-MB-231 breast cancer cells and mouse osteoblast MC3T3-E1 cells were cocultured to mimic the breast cancer bone metastasis microenvironment in vitro. qRT-PCR and Western blotting were used to detect the expressions of OPG and RANKL at the mRNA and protein levels, respectively, in brucine-treated cultures and they were compared to those in untreated cultures...
2017: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/29075304/effects-of-gualou-guizhi-decoction-aqueous-extract-on-axonal-regeneration-in-organotypic-cortical-slice-culture-after-oxygen-glucose-deprivation
#20
Lihong Nan, Lan Yang, Yanfang Zheng, Yibo He, Qingqing Xie, Zheming Chen, Huang Li, Mei Huang
Gualou Guizhi decoction (GLGZD) is effective for the clinical treatment of limb spasms caused by ischemic stroke, but its underlying mechanism is unclear. Propidium iodide (PI) fluorescence staining, terminal deoxynucleotidyl transferase-mediated dUTP-biotin nick end labeling (TUNEL), immunohistochemistry, western blot, and real-time qPCR were used to observe the axonal regeneration and neuroprotective effects of GLGZD aqueous extract on organotypic cortical slices exposed to oxygen-glucose deprivation (OGD) and further elucidate the potential mechanisms...
2017: Evidence-based Complementary and Alternative Medicine: ECAM
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