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Evidence-based Complementary and Alternative Medicine: ECAM

Wing-Sum Siu, Hoi-Ting Shiu, Chun-Hay Ko, Wai-Ting Shum, Ho-Nam Yu, Clara Bik-San Lau, Leung-Kim Hung, Ping-Chung Leung
Strontium ranelate (SrR) is one of the pharmaceutical agents reported to be effective on the promotion of fracture healing. This study aimed to evaluate the integrative effect of the oral SrR with a topical Chinese herbal paste, namely, CDR, on facilitation of bone healing. The in vivo efficacy was evaluated using rats with tibial fracture. They were treated with either CDR topically, or SrR orally, or their combined treatments. The in vivo results illustrated a significant additive effect of CDR on SrR in increasing the yield load of the fractured tibia...
2017: Evidence-based Complementary and Alternative Medicine: ECAM
Marie Alfrede Mvondo, Stéphane Minko Essono, Francis Désiré Bomba Tatsinkou, Sylvin Benjamin Ateba, Dieudonné Njamen
Entada africana (Mimosaceae) was reported to have analgesic and antioxidant properties. The present study is aimed at investigating the effects of the root aqueous extract of Entada africana (EA) on an experimental model of endometriosis. The study was performed in rats orally treated with EA at doses of 127.5, 255, and 510 mg/kg. Microgynon® 30 served as the reference substance. Estradiol valerate and oxytocin were used to induce dysmenorrhea. Endometrial implant levels of catalase and malondialdehyde (MDA) allowed estimating tissue oxidative status...
2017: Evidence-based Complementary and Alternative Medicine: ECAM
Qiu-Hong Wang, Shao-Wa Lv, Yu-Yan Guo, Ji-Xin Duan, Shu-Yu Dong, Qiu-Shi Wang, Feng-Ming Yu, Hong Su, Hai-Xue Kuang
Caulophyllum robustum Maxim (C. robustum) has commonly been used as traditional Chinese medicine for the treatment of rheumatic pain and rheumatoid arthritis (RA) in China. This paper first investigated the anti-inflammation effect of C. robustum extraction (CRME) on RAW264.7 cells stimulated by lipopolysaccharide (LPS) and gene expression levels of inflammatory factors. Moreover, we first evaluated the anti-RA effects of CRME using collagen-induced arthritis (CIA) in DBA/1J mice, and the incidence, clinical score, and joint histopathology were evaluated...
2017: Evidence-based Complementary and Alternative Medicine: ECAM
Meran Keshawa Ediriweera, Kamani Hemamala Tennekoon, Sameera Ranganath Samarakoon
Mangifera indica (family Anacardiaceae), commonly known as mango, is a pharmacologically, ethnomedically, and phytochemically diverse plant. Various parts of M. indica tree have been used in traditional medicine for the treatment of different ailments, and a number of bioactive phytochemical constituents of M. indica have been reported, namely, polyphenols, terpenes, sterols, carotenoids, vitamins, and amino acids, and so forth. Several studies have proven the pharmacological potential of different parts of mango trees such as leaves, bark, fruit peel and flesh, roots, and flowers as anticancer, anti-inflammatory, antidiabetic, antioxidant, antibacterial, antifungal, anthelmintic, gastroprotective, hepatoprotective, immunomodulatory, antiplasmodial, and antihyperlipemic...
2017: Evidence-based Complementary and Alternative Medicine: ECAM
He Peiyuan, Hou Zhiping, Song Chengjun, Wang Chunqing, Li Bingqing, Mustapha Umar Imam
The aim of this study was to investigate the hepatoprotective effects of resveratrol in alcoholic liver disease (ALD). Alcohol was administered to healthy female rats starting from 6% (v/v) and gradually increased to 20% (v/v) by the fifth week. After 16 weeks of intervention, liver enzymes (aspartate aminotransferase [AST] and alanine aminotransferase [ALT]) were analyzed using a chemistry analyzer, while hepatic antioxidant enzymes, oxidative stress markers, and caspase 3 activity were assessed using ELISA kits...
2017: Evidence-based Complementary and Alternative Medicine: ECAM
Li-Ling Shen, Chih-Hsin Muo, Shan-Yu Su, Donald E Morisky
The Pap test diagnosed cervical dysplasia, which could recover to normal or progress to cervical cancer (CC), is an early stage of cell abnormality before CC. This case-control study analyzed the differences in the risk to develop CC between Chinese medicine (CM) users and nonusers among women who had ever been diagnosed as having cervical dysplasia. A total of 750 CC patients with a cervical dysplasia history were collected between 1998 and 2011 from National Health Insurance Research Database, and controls were women with cervical dysplasia history but did not develop CC...
2017: Evidence-based Complementary and Alternative Medicine: ECAM
Boyoung Jung, Sukjin Bae, Soyoon Kim
This study aimed to compare the usage of Western medicine and traditional Korean medicine for treating joint disorders in Korea. Data of claims from all medical institutions with billing statements filed to HIRA from 2011 to 2014 for the four most frequent joint disorders were used for the analysis. Data from a total of 1,100,018 patients who received medical services from 2011 to 2014 were analyzed. Descriptive statistics are presented as type of care and hospital type. All statistical analyses were performed using IBM SPSS for Windows version 21...
2017: Evidence-based Complementary and Alternative Medicine: ECAM
Jun-Ming Huang, Yuan Bao, Wei Xiang, Xing-Zhi Jing, Jia-Chao Guo, Xu-Dong Yao, Rui Wang, Feng-Jin Guo
Fat infiltration within the bone marrow is easily observed in some postmenopausal women. Those fats are mainly derived from bone marrow mesenchymal stem cells (BMMSCs). The increment of adipocytes derived from BMMSCs leads to decreased osteoblasts derived from BMMSCs, so the bidirectional differentiation of BMMSCs significantly contributes to osteoporosis. Icariin is the main extractive of Herba Epimedii which is widely used in traditional Chinese medicine. In this experiment, we investigated the effect of icariin on the bidirectional differentiation of BMMSCs through quantitative real-time PCR, immunofluorescence, western blot, and tissue sections in vitro and in vivo...
2017: Evidence-based Complementary and Alternative Medicine: ECAM
Shuai Yan, Yin-Zi Yue, Xiao-Peng Wang, Hong-Li Dong, Shu-Guang Zhen, Ben-Sheng Wu, Hai-Hua Qian
Traditional Chinese medicine was reported to have good effects in treating functional constipation. This work attempted to prove the effects of aqueous extracts of Herba Cistanche (AEHC) on STC treatment and to determine the possible mechanisms by a loperamide-induced slow transit constipation (STC) model. HPLC was performed for identification and confirmation of the bioactive components in the AEHC. It was found that AEHC attenuated STC responses based on increased fecal quantity, moisture content, and intestinal transit rate, as well as serum levels of GAS, MTL, SS, and CGRP...
2017: Evidence-based Complementary and Alternative Medicine: ECAM
Ibrahim Semuyaba, Abass Alao Safiriyu, Emmanuel Ayikobua Tiyo, Remón Figueredo Niurka
Studies suggest that garlic ( A. sativum ) improves memory dependent on the hippocampus. However, the effect of ethanol garlic extract on hippocampus Na + /K + ATPase, Ca 2+ ATPase, and glutamine synthetase (GS) activities as possible mechanisms in memory improvement in diabetic Wistar rats has not been reported. Twenty-four male Wistar rats weighing 200-250 g were divided into three groups with 8 rats each. Group (A), normal control rats, and Group (B), diabetic rats, received 1 ml of normal saline; diabetic rats in Group (C) received 1000 mg/kg of garlic extract orally for 21 days...
2017: Evidence-based Complementary and Alternative Medicine: ECAM
Saleh Abu-Lafi, Mahmoud Sami Al-Natsheh, Reem Yaghmoor, Fuad Al-Rimawi
The production of olive oil generates massive quantities of by-product called olive mill wastewater (OMWW). The uncontrolled disposal of OMWW poses serious environmental problems. The OMWW effluent is rich in several polyphenolic compounds. Liquid-liquid extraction of OMWW using ethyl acetate solvent was used to enrich phenolic compounds under investigation. Total phenolic and flavonoid content and antioxidant activity of the extract were determined. HPLC coupled to photodiode array (PDA) detector was used to analyze the main three phenolic compounds of OMWW, namely, hydroxytyrosol, tyrosol, and oleuropein...
2017: Evidence-based Complementary and Alternative Medicine: ECAM
Chunhoo Cheon, Jeong-Eun Yoo, Hwa-Seung Yoo, Chong-Kwan Cho, Sohyeon Kang, Mia Kim, Bo-Hyoung Jang, Yong-Cheol Shin, Seong-Gyu Ko
Background: Anorexia occurs in about half of cancer patients and is associated with high mortality rate. However, safe and long-term use of anorexia treatment is still an unmet need. Objective: The purpose of the present study was to examine the feasibility of Sipjeondaebo-tang (Juzen-taiho-to, Shi-Quan-Da-Bu-Tang) for cancer-related anorexia. Methods: A total of 32 participants with cancer anorexia were randomized to either Sipjeondaebo-tang group or placebo group...
2017: Evidence-based Complementary and Alternative Medicine: ECAM
Yoon Hee Lee, Bora Jin, Sunghyun Lee, Jin-Young Oh, Jungbin Song, Donghun Lee, Young-Sik Kim, Hocheol Kim
Menopause is strongly associated with an increased risk of metabolic dysfunctions due to the decline in estrogen. Here, we hypothesized that dietary HT051, containing the roots of Pueraria lobata and Rehmannia glutinosa , has beneficial effects on ovariectomized (OVX) rats by regulating lipid metabolism. Forty-eight female Sprague-Dawley rats were randomly divided into 4 groups: sham-operated (Sham), OVX, OVX with low-dose HT051 supplementation, and OVX with high-dose HT051 supplementation. The rats were fed with a modified AIN-93G diet or an HT051-containing modified AIN-93G diet for 8 weeks...
2017: Evidence-based Complementary and Alternative Medicine: ECAM
Nam-Woo Lee, Gee-Heon Kim, In Heo, Koh-Woon Kim, In-Hyuk Ha, Jun-Hwan Lee, Eui-Hyoung Hwang, Byung-Cheul Shin
Objective: To review the literature and systematically evaluate the effectiveness of Chuna (or Tuina) manual therapy (C[T]MT) on pain and function for musculoskeletal disorders. Methods: We searched 15 English, Chinese, Japanese, and Korean databases using relevant keywords. All randomized controlled trials (RCTs) of C(T)MT for musculoskeletal disorders were considered, and we limited analyses to studies with a low-risk bias for randomization and/or allocation concealment...
2017: Evidence-based Complementary and Alternative Medicine: ECAM
Md Anisuzzman, Md Mahedi Hasan, Amit Kumar Acharzo, Asish Kumar Das, Sinthia Rahman
Background. Dalbergia species has wide range of secondary metabolites and is traditionally used in treatment of painful micturition, swelling, and leprosy and as blood tonic. The study evaluates membrane stabilizing, anticoagulant, analgesic, cytotoxic, subacute anti-inflammatory, and depression potentials of D. candenatensis leaves metabolites. Methods . Membrane stabilizing activity was evaluated by hypotonic induced hemolysis assay, whereas anticoagulant activity is done through extrinsic pathway by measuring prothrombin time...
2017: Evidence-based Complementary and Alternative Medicine: ECAM
Wangyu Liu, Shan Lin, Qiaoyan Cai, Ling Zhang, Aling Shen, Youqin Chen, Jianfeng Chu, Jun Peng
Qingxuan Jiangya Decoction (QXJYD) is a traditional Chinese medicine commonly used in the clinical treatment of hypertension. Earlier studies had shown that QXJYD could inhibit the elevation of blood pressure in spontaneously hypertensive rats (SHRs) and prevent remodeling of arterial vessels. This study examines the therapeutic efficacy of QXJYD against elevated blood pressure using the SHR model, as well as the mechanisms behind its antihypertensive activity and protection against renal fibrosis. The results showed that QXJYD significantly attenuated the increase in blood pressure in SHRs and mitigated the development of renal interstitial fibrosis...
2017: Evidence-based Complementary and Alternative Medicine: ECAM
Cui Liu, Chao Zhang, Weijie Lv, Limin Chao, Zengquan Li, Dayou Shi, Shining Guo
To determine whether the traditional Chinese herbal formula of Shen Ling Baizhu (SLB) could modulate the composition of the gut microbiota and alleviate diarrhoea in suckling piglets, twenty-four newly born piglets (Large White × Landrace × Duroc) were selected and allocated to 4 groups (control group and experimental groups I, II, and III) randomly. Faecal microbiome composition was assessed by 16S rRNA gene 454-pyrosequencing. The result indicated that experimental groups I and II exhibited significantly different gut microbiota from the control group...
2017: Evidence-based Complementary and Alternative Medicine: ECAM
Longsheng Deng, Xikui Zhang, Weikun Zhu, Taikun Lu, Jinchun Chen, Qiang Zou, Qizhong Zheng, Junying Chen, Changming Jiang, Guanyu Jin
The present study aimed to investigate the therapeutic effects of the Chinese herbal medicine Yin Zhi Huang soup (YZS) in an experimental autoimmune prostatitis (EAP) rat model. In total, 48 rats were randomly divided into the following four groups (n = 12/group): saline group, pathological model group, Qianlietai group, and YZS group. We determined the average wet weight of the prostate tissue, the ratio of the wet weight of the prostate tissue to body weight, tumor necrosis factor-alpha (TNF-α) levels in the blood serum, the expression of inducible nitric oxide synthase (iNOS) in the rats' prostate tissues, and the pathological changes in the prostate tissue using light microscopy...
2017: Evidence-based Complementary and Alternative Medicine: ECAM
Mysrayn Y F A Reis, Simone M Dos Santos, Danielle R Silva, Márcia V Silva, Maria Tereza S Correia, Daniela M A Ferraz Navarro, Geanne K N Santos, Fernando Hallwass, Otávio Bianchi, Alexandre G Silva, Janaína V Melo, Alessandra B Mattos, Rafael M Ximenes, Giovanna Machado, Karina L A Saraiva
Babassu oil extraction is the main income source in nut breakers communities in northeast of Brazil. Among these communities, babassu oil is used for cooking but also medically to treat skin wounds and inflammation, and vulvovaginitis. This study aimed to evaluate the anti-inflammatory activity of babassu oil and develop a microemulsion system with babassu oil for topical delivery. Topical anti-inflammatory activity was evaluated in mice ear edema using PMA, arachidonic acid, ethyl phenylpropiolate, phenol, and capsaicin as phlogistic agents...
2017: Evidence-based Complementary and Alternative Medicine: ECAM
Xuemei Liu, Juanjuan Fu, Tao Fan, Wei Liu, Hongli Jiang, Ruiming Zhang, Hong Ding, Haimiao Yang, Siyuan Hu, Yuhong Huang, Guanhong Li, Ying Lan, Bin She, Bing Mao
Background: Common cold is one of the most frequently occurring illnesses in primary healthcare services and represents considerable disease burden. Common cold of Qi-deficiency syndrome (CCQDS) is an important but less addressed traditional Chinese medicine (TCM) pattern. We designed a protocol to explore the efficacy, safety, and optimal dose of Shen Guo Lao Nian Granule (SGLNG) for treating CCQDS. Methods/Design: This is a multicenter, randomized, double-blind, placebo-controlled, phase II clinical trial...
2017: Evidence-based Complementary and Alternative Medicine: ECAM
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