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Evidence-based Complementary and Alternative Medicine: ECAM

Kamonwan Jenwitheesuk, Porntip Rojsanga, Bowornsilp Chowchuen, Palakorn Surakunprapha
Objective: This study was performed to evaluate the efficacy of Centella asiatica extract in cream, a preparation for the prevention of scar development of the split-thickness skin graft (STSG) donor site. Methods: A prospective randomized, double-blind control study was performed to evaluate the efficacy of Centella cream in 30 patients who underwent a STSG operation. Both Centella cream and placebo were applied equally to the donor site at least 2 weeks after epithelialization was completed...
2018: Evidence-based Complementary and Alternative Medicine: ECAM
Yong Meng, Ke Meng, Xin Zhao, Donghua Li, Qiaoying Gao, Shangwei Wu, Yunfeng Cui
The study attempted to elucidate whether lipid genes are closely associated with lipid metabolic abnormalities during the lithogenic time and how Yinchenhao Decoction (YCHD) works on the transcriptions of lipid genes against cholesterol gallstone model. C57BL/6J mice fed on lithogenic diet (LD) were used for model establishment and randomized into 5 groups. All groups received LD for different weeks with isometrically intragastric administration of YCHD or NS. Biochemical tests were measured and liver tissues were harvested for histological and genetic detection...
2018: Evidence-based Complementary and Alternative Medicine: ECAM
Qi-da He, Yuan-Peng Huang, Li-Bing Zhu, Jia-Cheng Shen, Lin-Yu Lian, Yuan Zhang, Long-Bin Zhang, Lin-Chao Qian, Xian-Jun Meng, Mi Liu, Cai-Chun Liu, Zong-Bao Yang
Acupuncture and moxibustion proved to be very effective in chronic atrophic gastritis (CAG). According to the Chinese traditional medicine theory, chronic diseases have an influence on the function of liver and kidney. However, there is little research to demonstrate this theory. This study is aimed at assessing the 1 H NMR-based metabolic profiling in liver and kidney of CAG rats and comparing the difference between electroacupuncture and moxibustion treatment. Male SD rats were subjected to CAG modeling by intragastric administration of mixture of 2% sodium salicylate and 30% alcohol coupled with compulsive sporting and irregular fasting for 12 weeks and then treated by electroacupuncture or moxibustion at Liangmen (ST 21) and Zusanli (ST 36) acupoints for 2 weeks...
2018: Evidence-based Complementary and Alternative Medicine: ECAM
Shanshan Guo, Lei Bao, Tiange Qu, Xin Mao, Yingjie Gao, Yingli Xu, Xiaolan Cui
Mycoplasma pneumoniae (MP) infection is a major pathogen of community-acquired pneumonia (CAP) in children worldwide. Infantile Feire Kechuan Oral Solution (IFKOS) has been used for the treatment of MP pneumonia clinically in China for many years. The present study was designed to investigate the therapeutic effect of IFKOS on MP pneumonia and explore the potential mechanism of the actions. The infant BALB/c mouse and Wistar rat models of MP infection were successfully established to confirm the therapeutic effects of IFKOS, followed by assays for related cytokines and investigations of the IgM response involved...
2018: Evidence-based Complementary and Alternative Medicine: ECAM
Claudio Molinari, Ian Stoppa, Nicola Limardo, Francesca Uberti
The potentially harmful nature of electromagnetic fields (EMF) and static magnetic fields (SMF) has become a major problem in recent years. All these elements could be combined to produce cellular responses. For example, the orientation of molecules of water or other complex molecules, growth and cell viability, cell morphology, and intracellular metabolic pathways have demonstrated binding to magnetic fields. The effect of EMF and SMF on humans is a topic of great importance, especially because modern technology has introduced artificial magnetic fields such as those generated by power lines, mobile communications, and medical imaging equipment...
2018: Evidence-based Complementary and Alternative Medicine: ECAM
Christian Kuété Fofié, Elvine Pami Nguelefack-Mbuyo, Nole Tsabang, Albert Kamanyi, Télesphore Benoît Nguelefack
Parts of Ceiba pentandra are wildly used in Africa to treat diabetes and previous works have demonstrated their in vivo antidiabetic effects on type 1 diabetes models. In addition, it has been recently shown that the decoction and the methanol extract from the stem bark of C. pentandra potentiate in vitro, the peripheral glucose consumption by the liver and skeletal muscle slices. But nothing is known about its effect on type II diabetes, especially on insulin resistance condition. We investigated herein the antihyperglycemic, insulin-sensitizing potential, and cardioprotective effects of the dried decoction from the stem bark of Ceiba pentandra (DCP) in dexamethasone-induced insulin resistant rats...
2018: Evidence-based Complementary and Alternative Medicine: ECAM
Kai Wu, Chong-Zhi Wang, Chun-Su Yuan, Wei-Hua Huang
Oplopanax horridus , well-known as Devil's club, is probably the most important ethnobotanical to most indigenous people living in the Pacific Northwest of North America. Compared with the long history of traditional use and widespread distribution in North America, the study of O. horridus is relatively limited. In the past decade, some exciting advances have been presented on the phytochemistry and pharmacological diversity and structure-activity relationship on anticancer effects of O. horridus . To date, no systematic review has been drafted on the recent advances of O...
2018: Evidence-based Complementary and Alternative Medicine: ECAM
Raha Orfali, Nasir Ali Siddiqui, Perwez Alam, Tawfeq Abdullah Alhowiriny, Areej Mohammad Al-Taweel, Sami Al-Yahya, Najwa Mohammed Majrashi, Rashad Mehmood, Shabana Iqrar Khan, Shagufta Perveen
Nepeta deflersiana (Lamiaceae) is a well-known medicinal plant that grows in Saudi Arabia. This plant is used in Saudi and Yemeni folk medicine as an anti-inflammatory, carminative, and antirheumatic agent. In order to prove its use in folk medicine, four different extracts from the aerial parts of the plant: petroleum ether, chloroform, ethyl acetate, and n -butanol extracts were subjected to biological assays to screen PPAR α and PPAR ϒ agnostic, antioxidant, anti-inflammatory, and cytotoxic activities...
2018: Evidence-based Complementary and Alternative Medicine: ECAM
Bin Yan, Jingbo Wang, Zhigang Xue, Guoqing Tian
Background: Diabetic cognitive impairment (DCI), a serious complication of diabetes mellitus (DM), is gaining more acceptance and attention. The learning and memory function of diabetics always decreases. Traditional Chinese medicine (TCM) has been demonstrated to be effective in treating the symptoms in China, and thereinto Chinese medicinal herbs (CMH) are the most widely used. The objective of the present study was to review and analyze the existing data about reducing the symptoms in CMH treatment for DCI...
2018: Evidence-based Complementary and Alternative Medicine: ECAM
Siu-Man Ng, Ling-Li Leng
Stagnation syndrome, a diagnostic entity in traditional Chinese medicine (TCM), has been long regarded as the TCM counterpart of major depression in Western medicine. The study investigated the prevalence of major depression among stagnation syndrome patients and evaluated their well-being and functioning outcomes. In total, 117 patients diagnosed with stagnation syndrome were measured using Stagnation Scale, the Patient Health Questionnaire-9 (PHQ-9), and the Body-Mind-Spirit Well-Being Inventory. Results indicate major depression among stagnation syndrome patients was characterized by a high co-occurrence rate and worse physical, mental, and functional outcomes...
2018: Evidence-based Complementary and Alternative Medicine: ECAM
Xin Qiu, Xinyu Wei, Hongwei Guan, Hao Su, Jing Gong, Ke Fang, Xin Zou, Hui Dong, Lijun Xu, Fuer Lu
Coptis chinensis (CC) is widely used to treat diabetes in traditional Chinese medicine due to its significant hypoglycemic and hypolipidemic effects. It was reported that CC powders are more effective than CC decoctions. In this study, a rat model of type 2 diabetes was established and treated with supercritical-extracted CC and gastric juice extracted CC, respectively. Body weight, fasting plasma insulin, insulin resistance index, and lipid profiles were measured along with oral glucose tolerance tests (OGTTs)...
2018: Evidence-based Complementary and Alternative Medicine: ECAM
Loredana Cavalli, Lucia Briscese, Tiziana Cavalli, Paolo Andre, Maria Chiara Carboncini
Acupuncture therapy has been used to treat several disorders in Asian countries and its use is increasing in Western countries as well. Current literature assessed the safety and efficacy of acupuncture in the acute management and rehabilitation of patients with neurologic disorders. In this paper, the role of acupuncture in the treatment of acute severe acquired brain injuries is described, acting on neuroinflammation, intracranial oedema, oxidative stress, and neuronal regeneration. Moreover, beneficial effects of acupuncture on subacute phase and chronic outcomes have been reported in controlling the imbalance of IGF-1 hormone and in decreasing spasticity, pain, and the incidence of neurovegetative crisis...
2018: Evidence-based Complementary and Alternative Medicine: ECAM
Wei Wu, Bing Hou, Changli Tang, Fucheng Liu, Jie Yang, Tao Pan, Ke Si, Deyun Lu, Xiaoxiang Wang, Jing Wang, Xing Xiong, Ji Liu, Chunguang Xie
Inhibition of tumor cell migration is a treatment strategy for patients with colorectal cancer (CRC). SCF-dependent activation of c-KIT is responsible for migration of c-KIT positive [c-KIT(+)] cells of CRC. Drug resistance to Imatinib Mesylate (c-KIT inhibitor) has emerged. Inhibition of mTOR can induce autophagic degradation of c-KIT. (+)-usnic acid [(+)-UA], isolated from lichens, has two major functions including induction of proton shuttle and targeting inhibition of mTOR. To reduce hepatotoxicity, the treatment concentration of (+)-UA should be lower than 10 μ M...
2018: Evidence-based Complementary and Alternative Medicine: ECAM
Lu-Da Feng, Yang Tian, Xin Wang, Run Dai, Song Cai, Yu-Jia Cao, Yin-Chu Si
Background: Therapy of nourishing kidney has been used for treating memory deficits of Alzheimer's disease (AD) for thousands of years based on traditional Chinese medicine. However, we found the therapy of dredging the bowels could alleviate both memory deficits and mental symptoms of AD in clinic. Objective: To determine whether the therapy of dredging the bowels could enhance the neuroprotective effect of nourishing kidney herbs for treating AD rats, and to explore the underlying mechanism of the combination of nourishing kidney and dredging the bowels (NKDB) herbs...
2018: Evidence-based Complementary and Alternative Medicine: ECAM
Negero Gemeda, Ashenif Tadele, Hirut Lemma, Biruktawit Girma, Getachew Addis, Birhanu Tesfaye, Abiy Abebe, Worku Gemechu, Kidist Yirsaw, Frehiwot Teka, Christina Haile, Aliyi Amano, Samuel Woldkidan, Bekesho Geleta, Asfaw Debella
Background: Skin infections were the most frequently encountered of all infections and the 4th leading cause of nonfatal disease burden. Topical drugs have been used for the management of skin infections. The growing concern of drug resistance to the topical agents has warned the need for continuous development of novel drug. Essential oils are the best candidate for new drug with different mode of action and target as they are rich in chemical constituents. Objective: To evaluate and develop safe and effective topical antimicrobial formulations from essential oil of Cymbopogon martini...
2018: Evidence-based Complementary and Alternative Medicine: ECAM
Baojin Yao, Bocheng Lu, Hongwei Gao, Mei Zhang, Xiangyang Leng, Daqing Zhao
Chinese materia medica (CMM) are essential components of traditional Chinese medicine, and Chinese medicinal formulas consisting of 2 or more types of CMM are widely used. These formulations have played a pivotal role in health protection and disease control for thousands of years. Guzhi Zengsheng Zhitongwan (GZZSZTW), which represents one of the Chinese medicinal formulations, has been used for several decades to treat joint diseases. However, the exact molecular mechanism underlying its efficacy in treating osteoarthritis remains to be elucidated...
2018: Evidence-based Complementary and Alternative Medicine: ECAM
Young Jun Koh, Ju-Hee Lee, Sung Yun Park
Background: Obesity is a pathological condition associated with various diseases including diabetes, stroke, arthritis, infertility, and heart disease. Moxibustion is widely used to prevent and manage obesity in traditional Asian medicine. We tested our hypothesis that moxibustion-simulating bipolar radiofrequency (M-RF) can suppress total body and white adipose tissue (WAT) weight gain via induction of WAT browning in a mouse model of diet-induced obesity (DIO). Methods: We designed an M-RF device that could accurately adjust the depth and temperature at which heat stimulation was administered into the abdomen of DIO mice...
2018: Evidence-based Complementary and Alternative Medicine: ECAM
Chao Hou, Dai-Han Zhou, Yong-Jian Wu, Xiao-Jun Dai, Qing-Ying Wang, Yin-Qiu Wu, En-Xin Zhang
Non-small cell lung cancer (NSCLC) is a serious threat to people's health. This study aims to determine the possible effect of Gujin Xiaoliu Tang (GJXLT) on NSCLC, which is an empirical formula from Professor Dai-Han Zhou. In this study, chromatographic fingerprinting of GJXLT and A549 cell model in vitro and in vivo was established. We cultured A549 cells in vitro and found that GJXLT inhibited A549 cell growth and induced apoptosis. Compared with the control group, the expression of p-STAT3 and VEGF proteins in the GJXLT groups was decreased...
2018: Evidence-based Complementary and Alternative Medicine: ECAM
Bernardino Clavo, Norberto Santana-Rodríguez, Pedro Llontop, Dominga Gutiérrez, Gerardo Suárez, Laura López, Gloria Rovira, Gregorio Martínez-Sánchez, Esteban González, Ignacio J Jorge, Carmen Perera, Jesús Blanco, Francisco Rodríguez-Esparragón
Introduction: This article provides an overview of the potential use of ozone as an adjuvant during cancer treatment. Methods: We summarize the findings of the most relevant publications focused on this goal, and we include our related clinical experience. Results: Over several decades, prestigious journals have published in vitro studies on the capacity of ozone to induce direct damage on tumor cells and, as well, to enhance the effects of radiotherapy and chemotherapy...
2018: Evidence-based Complementary and Alternative Medicine: ECAM
Marieke Van Puymbroeck, Alysha A Walter, Brent L Hawkins, Julia L Sharp, Kathleen Woschkolup, Enrique Urrea-Mendoza, Fredy Revilla, Emilie V Adams, Arlene A Schmid
[This corrects the article DOI: 10.1155/2018/8516351.].
2018: Evidence-based Complementary and Alternative Medicine: ECAM
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