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Evidence-based Complementary and Alternative Medicine: ECAM

Shu Liang, Yupei Zhang, Yuanjun Deng, Yifang He, Yinji Liang, Zien Liang, Yanning Chen, Kairui Tang, Runsen Chen, Qinhe Yang
The present study investigates the potential therapeutic mechanism underlying the effects of the Chinese herbal formula Hongqijiangzhi Fang (HJF) on nonalcoholic fatty liver disease (NAFLD) in rats. Male Sprague Dawley (SD) rats were randomly divided into 4 groups ( n = 8): control group was fed a normal diet, three other groups were fed high-fat diets (HFD), and the two treatment groups were intragastrically given a compound probiotic or HJF during the molding time. After 16 w, related indices were detected...
2018: Evidence-based Complementary and Alternative Medicine: ECAM
Yunbo Chen, Guijuan Zhang, Xiaoping Chen, Xuefeng Jiang, Fengjie Bie, Naijun Yuan, Yurong Wang, Xiaoqian Hao, Min Ma
Objective. To investigate the effects of Jianpi Bushen (JPBS), a traditional Chinese medicine that is used to invigorate the spleen and tonify the kidney, combined with chemotherapy for the treatment of gastric cancer. Methods. Literature retrieval was performed in PubMed, EMBASE, Cochrane Library, MEDLINE, CNKI, Wanfang Data Information Site, and VIP from inception to October 2017. Randomized controlled trials to evaluate the effects of JPBS combined with chemotherapy were identified. The primary reported outcomes were KPS (Karnofsky Performance Status), clinical curative efficiency, immune function, blood system, and nonhematologic system...
2018: Evidence-based Complementary and Alternative Medicine: ECAM
Julio César López-Romero, Humberto González-Ríos, Aida Peña-Ramos, Carlos Velazquez, Moises Navarro, Ramón Robles-Zepeda, Evelin Martínez-Benavidez, Inocencio Higuera-Ciapara, Claudia Virués, José Luis Olivares, Zaira Domínguez, Javier Hernández
This study shows the seasonal effect on the antioxidant, antiproliferative, and antimicrobial activities of L. glaucescens Kunth (LG) leaves extracts. Their antioxidant activity was evaluated through the DPPH, FRAP, and ORAC assays. Their phenolic content (PC) was determined by means of the Folin-Ciocalteu method, and the main phenolic compounds were identified through a HPLC-DAD analysis. Antiproliferative activity was determined by MTT assay against HeLa, LS 180, M12.C3.F6, and ARPE cell lines. Antimicrobial potential was evaluated against Staphylococcus aureus and Escherichia coli using a microdilution method...
2018: Evidence-based Complementary and Alternative Medicine: ECAM
Asnakech Alemu, Wondmagegn Tamiru, Teshome Nedi, Workineh Shibeshi
Background: Pain and inflammation are the major health problems commonly treated with traditional remedies mainly using medicinal plants. Leonotis ocymifolia is one of such medicinal plants used in folkloric medicine of Ethiopia. However, the plant has not been scientifically evaluated. The aim of this study was to evaluate analgesic and anti-inflammatory effects of the 80% methanol leaves extract of Leonotis ocymifolia using rodent models. Method: The central and peripheral analgesic effect of the extract at 100, 200, and 400 mg/kg dose levels was evaluated using hot plate and acetic acid induced writhing rodent models, whereas carrageenan induced paw edema and cotton pellet granuloma methods were used to screen anti-inflammatory effect of the extract at the same dose levels...
2018: Evidence-based Complementary and Alternative Medicine: ECAM
Yu Cai, Ying Wang, Fei Zhi, Qi-Chang Xing, Yun-Zhong Chen
Treating type 2 diabetes mellitus (T2DM) using thiazolidinediones and biguanides can present several challenges for patients. Sanggua Drink (SGD) is a commonly used agent in traditional Chinese medicine, and it consists of Folium Mori , Fructus Momordicae Charantiae , Radix Puerariae Lobatae , and Rhizoma Dioscorea . The hypoglycemic effects and mechanisms of SGD extracts on insulin resistance in diabetic rats were investigated. SGD (1.24 g/kg orally) was verified in T2DM rats induced by a high-fat diet and streptozotocin...
2018: Evidence-based Complementary and Alternative Medicine: ECAM
Dan-Dan Mao, Wen-Yu Yang, Yan Li, Jian-Wei Lin, Shi-Yu Gao, Yi-Ru Wang, Hai-Yan Hu
Objective: To investigate the effects of QKF on expression of amyloid-beta (A β ), interleukin-1 beta (IL-1 β ), and glial fibrillary acidic protein (GFAP) using a rat model of AD. Materials and Methods: Fifty-six male Sprague-Dawley rats were randomly divided into seven groups (eight rats each): control group, sham-operated group, AD model group, groups of AD rats administered with low, medium, and high doses of QKF, and the donepezil group. AD was established by bilateral injection of β -amyloid (A β ) 1-40 into the hippocampus...
2018: Evidence-based Complementary and Alternative Medicine: ECAM
Huilin Li, Shufang Chu, Hengxia Zhao, Deliang Liu, Xuemei Liu, Xi Qu, Jianpin Chen, Zengyin Li, Jinhua Li
Diabetic osteoporosis (DO) is a complication of diabetes. Zishen Jiangtang Pill (ZJP) is a Chinese herbal product which has been used in clinic to maintain blood glucose level and bone density for decades. However, the evidence about its mechanism on diabetes and osteoporosis is still unknown. The aim of this study is to investigate therapeutic effect of ZJP on DO in streptozotocin- (STZ-) induced rats. Rats were randomly assigned to 4 groups: one control group (CON), one model group (MOD), and two ZJP treatment groups (1...
2018: Evidence-based Complementary and Alternative Medicine: ECAM
Kai Sun, Xu Song, RenYong Jia, Zhongqiong Yin, Yuanfeng Zou, Lixia Li, Lizi Yin, Changliang He, Xiaoxia Liang, Guizhou Yue, Qiankun Cui, Yi Yang
Aim: Pain and inflammation are associated with many diseases in humans and animals. Galla Chinensis , a traditional Chinese medicine, has a variety of pharmacological properties. The purpose of this study was to evaluate analgesic and anti-inflammatory activities of Galla Chinensis through different animal models. Method: The analgesic activities were evaluated by hot-plate and writhing tests. The anti-inflammatory effects were assessed by ear edema, capillary permeability, and paw edema tests...
2018: Evidence-based Complementary and Alternative Medicine: ECAM
Yu Ri Kim, Min Young Kwon, Malk Eun Pak, So Hyun Park, Jin Ung Baek, Byung Tae Choi
From text mining of Dongeuibogam, the 7 herbs in Palmultang can be considered effective candidates for memory enhancement. We sought to determine whether Gagam-Palmultang, comprising these 7 herbs, ameliorates scopolamine-induced memory impairment in mice, by focusing on the central cholinergic system and memory-related signaling molecules. Behavioral tests were performed after inducing memory impairment by scopolamine administration. The cholinergic system activity and memory-related molecules were examined in the hippocampus by enzyme-linked immunosorbent, western blot, and immunofluorescence assays...
2018: Evidence-based Complementary and Alternative Medicine: ECAM
Katyakyini Muniandy, Sivapragasam Gothai, Woan Sean Tan, S Suresh Kumar, Norhaizan Mohd Esa, Govindasamy Chandramohan, Khalid S Al-Numair, Palanisamy Arulselvan
Impaired wound healing is one of the serious problems among the diabetic patients. Currently, available treatments are limited due to side effects and cost effectiveness. In line with that, we attempted to use a natural source to study its potential towards the wound healing process. Therefore, Alternanthera sessilis ( A. sessilis ), an edible and medicinal plant, was chosen as the target sample for the study. During this investigation, the wound closure properties using stem extract of A. sessilis were analyzed...
2018: Evidence-based Complementary and Alternative Medicine: ECAM
Xinxin Wang, Peng Shen, Dezhi Tang, Hao Xu, Hongfu Qiu, Tao Wu, Xiang Gao
Objective: To investigate the effects of Qi-Fang-Xi-Bi-Granules (QFXBGs) on cartilage morphology and methylation of C/ebp α (CCAAT/enhancer binding protein α ) at the promoter region. Methods: Knee osteoarthritis (KOA) modeling was performed in rats in accordance with Hulth's method, and control group received sham operation. Eight weeks after KOA modeling, the rats in the KOA modeling group were further divided into 6 groups. Each group was given the appropriate drug...
2018: Evidence-based Complementary and Alternative Medicine: ECAM
Jing Yu, Hui Ye, Jiang Li, Ning Li, Zong-Ming Shi, Xue-Zhi Zhang
Mass Galla chinesis et camelliae Fermentata ( Chinese gall leaven , CGL) was investigated for activities against Helicobacter pylori (H. pylori) both in vitro and in vivo . The agar dilution method and time-kill curves, as in vitro assays and an in vivo study using a Kunming mice model, were performed. CGL demonstrated a strong anti- Helicobacter pylori activity in vitro with the minimal inhibitory concentrations (MICs) against multiple H. pylori strains of 0.5~8 mg/ml and the decreasing trend time-kill curves when increasing CGL concentrations...
2018: Evidence-based Complementary and Alternative Medicine: ECAM
Daeun Lee, Jung Hwa Yoo, Byung-Cheol Lee
Obesity results in the progression of metabolic disorders, especially type 2 diabetes (T2DM). Obesity-induced insulin resistance (IR) is a causative factor of T2DM morbidity in obese people. It is generally held by clinicians that IR is caused by adiposity-related inflammation that is mediated by changes in composite ions in the gut microbiome. This experimental study was designed to investigate the effects of Cucumis melo L. (Cucumis) on obesity-induced IR in genetically leptin-deficient Lepob /Lepob mice...
2018: Evidence-based Complementary and Alternative Medicine: ECAM
Juan Zhong, Dan Lai, Yun Zheng, Gang Li
Background: The treatment effects and safety of Ma-Huang-Fu-Zi-Xi-Xin decoction for patients with allergic rhinitis have yet to be clarified. Objectives: The aim of this study is to evaluate the effects and safety of Ma-Huang-Fu-Zi-Xi-Xin decoction in patients with allergic rhinitis. Methods: We searched PubMed, EMBASE (Excerpta Medical Database), Cochrane Library, Chinese Cochrane Centre's Controlled Trials Register Platform, Wanfang Chinese Digital Periodical and Conference Database, China National Knowledge Infrastructure (CNKI) Database, and VIP Chinese Science and Technique Journals Database to collect randomized controlled trials of Ma-Huang-Fu-Zi-Xi-Xin decoction (MHFZXXD) for allergic rhinitis (AR) prior to May 8, 2017...
2018: Evidence-based Complementary and Alternative Medicine: ECAM
Han-Cheng Li, Ying-Bo Lin, Chan Li, Chao-Hua Luo, Yu-Ting Zhou, Jing-Ying Ou, Jing Li, Zhi-Xian Mo
Objective: To compare the expressions of miRNAs (microRNAs) in serum exosomes and in hippocampus and to provide insights into the miRNA-mediated relationship between peripheral and central nervous systems in the presence of methamphetamine. Methods: Published results on conditioned place preference (CPP) in rats conditioned by methamphetamine were replicated. The expressions of miRNAs in serum exosomes and hippocampus were determined by gene-chip sequencing. We then predicted the potential target genes of selected, differentially expressed (DE) miRNAs and then carried out functional analysis of these target genes...
2018: Evidence-based Complementary and Alternative Medicine: ECAM
Ying Peng, Min Fan, Chongsheng Peng, Mengyue Wang, Xiaobo Li
Tiaowei Chengqi Tang (TWCQT) is composed of rhubarb, processed liquorice, and Natrii Sulfas, which is used as a purgative in traditional Chinese medicine (TCM). This study focused on the intestinal absorption of rhein in disassembly of the TWCQT extracts through the Caco-2 cell monolayer model to explicate the possible detoxification mechanism of herb-herb compatibility in TWCQT. The results showed that the intestinal absorption of rhein occurred through active diffusion, and rhein might be composed of breast cancer resistance protein (BCRP) substrates...
2018: Evidence-based Complementary and Alternative Medicine: ECAM
Tiffany C Y Cheung, Karen P Y Liu, Janet Y H Wong, Young-Hyeon Bae, Stanley Sai-Chuen Hui, William W N Tsang, Yoyo T Y Cheng, Shirley S M Fong
This study explored the immediate effects of Tai Chi (TC) training on attention and meditation, perceived stress level, heart rate, oxygen saturation level in blood, and palmar skin temperature in late middle-aged adults. Twenty TC practitioners and 20 nonpractitioners volunteered to join the study. After baseline measurements were taken, the TC group performed TC for 10 minutes while their cognitive states and cardiovascular responses were concurrently monitored. The control group rested for the same duration in a standing position...
2018: Evidence-based Complementary and Alternative Medicine: ECAM
Huanan Wang, Bing Mao, Chang Chen
Effective treatment for chronic obstructive pulmonary disease (COPD) and knowledge of the underlying mechanism are urgently required. Xiaoqinglong decoction (XQL) is widely used to treat COPD in Traditional Chinese Medicine, but the mechanism remains unclear. In this study, we tested the hypothesis that XQL ameliorates COPD via inhibition of autophagy in lung tissue on a rat model. Rats were divided into five groups, namely, Control group, COPD group, COPD + XQL group, COPD + Rapamycin group, and COPD + XQL + Rapamycin group...
2018: Evidence-based Complementary and Alternative Medicine: ECAM
Hyeonseok Noh, Seong Woo Yoon, Bongki Park
Background: Chemotherapy-induced peripheral neuropathy (CIPN) is a common adverse effect in cancer patients. The aim of this review was to assess the effectiveness of herbal medicine in preventing and treating CIPN. Methods: Randomised controlled trials were included in this review. Extracting and assessing the data independently, two authors searched 13 databases. Results: Twenty-eight trials involving 2174 patients met the inclusion criteria...
2018: Evidence-based Complementary and Alternative Medicine: ECAM
Li Yanwei, Yang Yinli, Zhanyu Pan
Antiangiogenic therapy is vital in nasopharyngeal carcinoma (NPC) treatment. NPC01 has already been successfully used in treating patients with NPC in clinical practice and exerted an excellent antiangiogenetic effect. However, the potential molecular mechanism underlying the antitumor effect of NPC01 has not been well explored. The present study demonstrated that NPC01 could significantly inhibit cell proliferation and induce cell apoptosis in a dose-dependent manner in human NPC cell lines. Furthermore, NPC01 exerted antiproliferative and antiangiogenic effects in NPC xenograft mice...
2018: Evidence-based Complementary and Alternative Medicine: ECAM
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