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International Journal of Medical Sciences

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https://www.readbyqxmd.com/read/29725257/impact-of-matrix-metalloproteinase-11-gene-polymorphisms-upon-the-development-and-progression-of-hepatocellular-carcinoma
#1
Bin Wang, Chin-Jung Hsu, Hsiang-Lin Lee, Chia-Hsuan Chou, Chen-Ming Su, Shun-Fa Yang, Chih-Hsin Tang
Hepatocellular carcinoma (HCC) is a liver malignancy and a major cause of cancer mortality worldwide. Matrix metalloproteinase-11 (MMP-11), also known as stromelysin-3, plays a critical role during tumor migration, invasion and metastasis. Here, we report on the association between five single nucleotide polymorphisms (SNPs) - rs738791, rs2267029, rs738792, rs28382575, and rs131451 - of the MMP-11 gene and HCC susceptibility, as well as clinical outcomes, in 293 patients with HCC and in 586 cancer-free controls...
2018: International Journal of Medical Sciences
https://www.readbyqxmd.com/read/29725256/verteporfin-inhibits-yap-induced-bladder-cancer-cell-growth-and-invasion-via-hippo-signaling-pathway
#2
Liang Dong, Fan Lin, Wanjun Wu, Yuchen Liu, Weiren Huang
The highly conserved Hippo signaling pathway is one of the most important pathways involved in tumorigenesis and progress. Previous studies show that YAP, the transcriptional coactivator of Hippo pathway, is expressed highly in many clinical bladder cancer tissues and plays crucial role on bladder cancer progress. To find the YAP-specific target drug and its molecular mechanism in bladder cancer, we apply Verteporfin (VP), a YAP specific inhibitor to function as anti-bladder cancer drug and discover that VP is able to inhibit bladder cancer cell growth and invasion in a dosage dependent manner...
2018: International Journal of Medical Sciences
https://www.readbyqxmd.com/read/29725255/amacr-overexpression-acts-as-a-negative-prognostic-factor-in-oral-squamous-cell-carcinoma
#3
Hong-Lin He, Ying-En Lee, Min-Te Chang, Yow-Ling Shiue, Shih-Lun Chang, Tzu-Ju Chen, Chang-Ta Chiu
Background : Alpha-methylacyl-CoA racemase (AMACR) is a key enzyme responsible for the metabolism of branched-chain fatty acids. It has been found to be an important prognostic factor in numerous types of cancers. This study was aimed to investigate the expression of AMACR and its prognostic significance in patients with oral squamous cell carcinoma (SCC). Methods : Analysis of publicly available microarray data of oral SCC revealed that AMACR was significantly upregulated in tumor tissue compared with normal mucosa...
2018: International Journal of Medical Sciences
https://www.readbyqxmd.com/read/29725254/resveratrol-attenuates-denervation-induced-muscle-atrophy-due-to-the-blockade-of-atrogin-1-and-p62-accumulation
#4
Yuka Asami, Miki Aizawa, Masakazu Kinoshita, Junji Ishikawa, Kunihiro Sakuma
Decrease in activity stress induces skeletal muscle atrophy. A previous study showed that treatment with resveratrol inhibits muscular atrophy in mdx mice, a model of DMD. However, almost all studies using resveratrol supplementation have only looked at adaptive changes in the muscle weight. The present study was designed to elucidate whether the resveratrol-inducing attenuation of skeletal muscle actually reflects the adaptation of muscle fibers themselves, based on the modulation of atrogin-1- or p62-dependent signaling...
2018: International Journal of Medical Sciences
https://www.readbyqxmd.com/read/29725253/anti-biofilm-and-anti-virulence-efficacy-of-celastrol-against-stenotrophomonas-maltophilia
#5
Hye-Rim Kim, Dongsup Lee, Yong-Bin Eom
Stenotrophomonas maltophilia is a multi-drug resistant opportunistic pathogen that causes nosocomial infections in immunocompromised patients. This pathogen is difficult to treat owing to its intrinsic multidrug resistance and ability to form antimicrobial-tolerant biofilms. In the present study, we aimed to assess the potential use of celastrol as a novel anti-biofilm and/or anti-virulence agent against S. maltophilia . Results showed that celastrol at its sub-inhibitory doses decreased biofilm formation and disrupt the established biofilms produced by S...
2018: International Journal of Medical Sciences
https://www.readbyqxmd.com/read/29725252/potential-mirna-target-interactions-for-the-screening-of-gastric-carcinoma-development-in-gastric-adenoma-dysplasia
#6
Yu Jin Kim, Ki-Chul Hwang, Sang Woo Kim, Yong Chan Lee
Although miRNA markers have been identified for the pathological development of gastric adenocarcinoma (GAC), the underlying molecule mechanism are still not fully understood. Moreover, some gastric adenoma/dysplasia may progress to GAC. In this study, the miRNA expression profiles in normal and paired low-/high-grade dysplasia were analyzed using Affymetrix Gene-Chip miRNA arrays. Of the total 2578 mature miRNA probe sets, ~1600 showed positive signals when the between normal and paired low-/high-grade dysplasia were compared...
2018: International Journal of Medical Sciences
https://www.readbyqxmd.com/read/29725251/glucagon-like-peptide-1-receptor-agonist-and-glucagon-increase-glucose-stimulated-insulin-secretion-in-beta-cells-via-distinct-adenylyl-cyclases
#7
Young-Sun Lee, Hee-Sook Jun
Diabetes mellitus is a chronic disease in which the pancreas no longer produces enough insulin. Pancreatic alpha cell mass increases in response to insufficient insulin secretion. However, the reason for this increase is not clear. It is possible that the increased alpha-cells may stimulate compensatory insulin release in response to the insufficient insulin such as insulin resistance. In this study, we investigated whether glucagon and glucagon-like peptide-1 (GLP-1), hormones produced by alpha cells, contribute to insulin secretion in INS-1 cells, a beta cell line...
2018: International Journal of Medical Sciences
https://www.readbyqxmd.com/read/29725250/lipopolysaccharide-mediates-the-destruction-of-intercellular-tight-junction-among-renal-tubular-epithelial-cells-via-rhot1-smad-4-jam-3-pathway
#8
Shixiang Zheng, Zhuoyong Lin, Zhongwei Liu, Yipeng Liu, Wenwei Wu
Background: The morbidity of sepsis induced acute kidney injury remains unacceptable high and the mechanisms of that disease remains unclear. For urine backleak and intercellular tight junction among tubular epithelial cells (TECs) destruction often occur during sepsis induced acute kidney injury, we examined whether lipopolysaccharide could damage intercellular tight junction among TECs and associated mechanisms in our present study. Methods: HK-2 cells were cultured, transfected with different SiRNAs and stimulated with LPS and PYR-41...
2018: International Journal of Medical Sciences
https://www.readbyqxmd.com/read/29725249/single-nucleotide-polymorphisms-and-haplotypes-of-carbonic-anhydrase-9-can-predict-invasive-squamous-cell-carcinoma-of-uterine-cervix
#9
Huang-Pin Shen, Yi-Hsuan Hsiao, Shun-Fa Yang, Yu-Fan Liu, Jiunn-Liang Ko, Po-Hui Wang
This study aimed to explore the involvement of carbonic anhydrase 9 (CA9) single nucleotide polymorphisms (SNPs) in the development of invasive cancer of uterine cervix for Taiwanese women. Ninety-seven patients with cervical invasive squamous cell carcinoma and 88 with preinvasive squamous cell lesions as well as 324 control women were recruited. Two CA9 SNPs in exons, including rs2071676 (+201, G/A) in exon 1 and rs3829078 (+1081, A/G) in exon 7, rs1048638 (+1584, C/A) in 3'-untranslated region of exon 11, as well as an 18-base pair deletion/insertion (376deltion393) in exon 1 were selected and their genotypic distributions were determined by real-time polymerase chain reaction...
2018: International Journal of Medical Sciences
https://www.readbyqxmd.com/read/29725248/-hmgb1-genetic-polymorphisms-are-biomarkers-for-the-development-and-progression-of-breast-cancer
#10
Bi-Fei Huang, Huey-En Tzeng, Po-Chun Chen, Chao-Qun Wang, Chen-Ming Su, Yan Wang, Gui-Nv Hu, Yong-Ming Zhao, Qian Wang, Chih-Hsin Tang
Breast cancer is a major cause of cancer mortality worldwide. High-mobility group box protein 1 (HMGB1) is a ubiquitous nuclear protein found in all mammal eukaryotic cells that participates in tumor progression, migration and metastasis. HMGB1 overexpression has been indicated in breast cancer patients. However, scant information is available regarding the association between HMGB1 single nucleotide polymorphisms (SNPs) and the risk or prognosis of breast cancer. We report on the association between 4 SNPs of the HMGB1 gene (rs1360485, rs1045411, rs2249825 and rs1412125) and breast cancer susceptibility as well as clinical outcomes in 313 patients with breast cancer and in 217 healthy controls...
2018: International Journal of Medical Sciences
https://www.readbyqxmd.com/read/29725247/-salmonella-overcomes-drug-resistance-in-tumor-through-p-glycoprotein-downregulation
#11
Chih-Jen Yang, Wen-Wei Chang, Song-Tao Lin, Man-Chin Chen, Che-Hsin Lee
Chemotherapy is one of effective methods for the treatment of tumor. Patients often develop drug resistance after chemotherapic cycles. Salmonella has potential as antitumor agent. Salmonella used in tandem with chemotherapy had additive effects, providing a rationale for using tumor-targeting Salmonella in combination with conventional chemotherapy. To improve the efficacy and safety of Salmonella , a further understanding of Salmonella interactions with the tumor microenvironment is required. The presence of plasma membrane multidrug resistance protein P-glycoprotein (P-gp) is highly relevant for the success of chemotherapy...
2018: International Journal of Medical Sciences
https://www.readbyqxmd.com/read/29725246/dehydroepiandrosterone-supplementation-combined-with-weight-loading-whole-body-vibration-training-wwbv-affects-exercise-performance-and-muscle-glycogen-storage-in-middle-aged-c57bl-6-mice
#12
Yi-Ming Chen, Hao-Chieh Lee, Mu-Tsung Chen, Chi-Chang Huang, Wen-Chyuan Chen
Background : Adequate nutritional intake and an optimal training program are important elements of any strategy to preserve or increase muscle mass and strength during aging. Purpose : In the current study, we investigate the effects of Dehydroepiandrosterone (DHEA), one of the most abundant circulating steroids in humans and a precursor hormone, supplementation combined with a weight-loading whole-body vibration (WWBV) on exercise performance, physical fatigue-related biochemical responses and testosterone content in middle-aged 9 months old C57BL/6 mice...
2018: International Journal of Medical Sciences
https://www.readbyqxmd.com/read/29725245/vascular-calcification-and-left-ventricular-hypertrophy-in-hemodialysis-patients-interrelationship-and-clinical-impacts
#13
Hyeon Seok Hwang, Jung Sun Cho, Yu Ah Hong, Yoon Kyung Chang, Suk Young Kim, Seok Joon Shin, Hye Eun Yoon
Background: We examined the relationship and combined effect of vascular calcification (VC) and left ventricular hypertrophy (LVH) on deaths and cardiovascular events (CVEs) in hemodialysis (HD) patients. Methods: Maintenance HD patients (n=341) were included. Echocardiography data and plain chest radiographs were used to assess LVH and aortic arch VC. Results: VC was found in 100 patients (29.3%). LVH was more prevalent in patients with VC compared with those without VC (70% vs. 50.2%, P =0.001). VC was independently associated with a 2...
2018: International Journal of Medical Sciences
https://www.readbyqxmd.com/read/29725244/cervical-dilatation-curves-of-spontaneous-deliveries-in-pregnant-japanese-females
#14
Yusuke Inde, Akihito Nakai, Atsuko Sekiguchi, Masako Hayashi, Toshiyuki Takeshita
Background: Although cervical dilatation curves are crucial for appropriate management of labor progression, abnormal labor progression and obstetric interventions were included in previous and widely-used cervical dilatation curves. We aimed to describe the cervical dilatation curves of normal labor progression in pregnant Japanese females without abnormal labor progression and obstetric interventions. Methods: We completed retrospective obstetric record reviews on 3172 pregnant Japanese females (parity = 0, n = 1047; parity = 1, n = 1083; parity ≥ 2, n = 1042), aged 20 to 39 years old at delivery, with pregravid body mass indices of less than 30...
2018: International Journal of Medical Sciences
https://www.readbyqxmd.com/read/29725243/mirna-135b-contributes-to-triple-negative-breast-cancer-molecular-heterogeneity-different-expression-profile-in-basal-like-versus-non-basal-like-phenotypes
#15
Paolo Uva, Paolo Cossu-Rocca, Federica Loi, Giovanna Pira, Luciano Murgia, Sandra Orrù, Matteo Floris, Maria Rosaria Muroni, Francesca Sanges, Ciriaco Carru, Andrea Angius, Maria Rosaria De Miglio
The clinical and genetic heterogeneity of Triple Negative Breast Cancer (TNBC) and the lack of unambiguous molecular targets contribute to the inadequacy of current therapeutic options for these variants. MicroRNAs (miRNA) are a class of small highly conserved regulatory endogenous non-coding RNA, which can alter the expression of genes encoding proteins and may play a role in the dysregulation of cellular pathways. Our goal was to improve the knowledge of the molecular pathogenesis of TNBC subgroups analyzing the miRNA expression profile, and to identify new prognostic and predictive biomarkers...
2018: International Journal of Medical Sciences
https://www.readbyqxmd.com/read/29559842/advancis-score-predicts-acute-kidney-injury-after-percutaneous-coronary-intervention-for-acute-coronary-syndrome
#16
Pei-Chun Fan, Tien-Hsing Chen, Cheng-Chia Lee, Tsung-Yu Tsai, Yung-Chang Chen, Chih-Hsiang Chang
Acute kidney injury (AKI), a common and crucial complication of acute coronary syndrome (ACS) after receiving percutaneous coronary intervention (PCI), is associated with increased mortality and adverse outcomes. This study aimed to develop and validate a risk prediction model for incident AKI after PCI for ACS. We included 82,186 patients admitted for ACS and receiving PCI between 1997 and 2011 from the Taiwan National Health Insurance Research Database and randomly divided them into a training cohort (n = 57,630) and validation cohort (n = 24,656) for risk model development and validation, respectively...
2018: International Journal of Medical Sciences
https://www.readbyqxmd.com/read/29559841/atorvastatin-attenuates-metabolic-remodeling-in-ischemic-myocardium-through-the-downregulation-of-ucp2-expression
#17
Chunyan Yang, Dongming Zhao, Guohui Liu, Haikuo Zheng, Hongliang Yang, Sibao Yang, Ping Yang
Uncoupling protein 2 (UCP2) is primarily expressed in the myocardium and is closely related to myocardial ischemia/reperfusion injury and myocardial metabolism. To explore the effects and the mechanisms of UCP2 on atorvastatin-mediated myocardium protection, the rat model of myocardial ischemia was established by ligation of the left anterior descending coronary arteries (LADs). The rats were divided into the sham operation (SO) group, myocardial infarction (MI) group and MI-atorvastatin group. The study that atorvastatin reduced myocardial remodeling and improved the disturbed myocardial energy metabolism after MI...
2018: International Journal of Medical Sciences
https://www.readbyqxmd.com/read/29559840/dexamethasone-down-regulates-osteocalcin-in-bone-cells-through-leptin-pathway
#18
Shu-Mei Chen, Yi-Jen Peng, Chih-Chien Wang, Sui-Lung Su, Donald M Salter, Herng-Sheng Lee
Glucocorticoid therapy, especially at higher doses, is associated with significant adverse side effects including osteoporosis. Leptin, secreted from adipose tissue, has diverse effects on bone tissue regulation. As glucocorticoids stimulate leptin synthesis and secretion directly in adipose tissue we hypothesised that dexamethasone (DEX) induced osteoporosis may, in part, be mediated by an osteoblast dependent leptin-leptin receptor pathway. Human bone cells expressed leptin and leptin receptors (Ob-Ra and Ob-Rb)...
2018: International Journal of Medical Sciences
https://www.readbyqxmd.com/read/29559839/synthesis-and-in-vitro-experiments-of-carcinoma-vascular-endothelial-targeting-polymeric-nano-micelles-combining-small-particle-size-and-supermagnetic-sensitivity
#19
Yi Zhang, Jielin Pan, Qilan Xu, Hao Li, Jianhao Wang, Chao Zhang, Guobin Hong
Objective: To construct carcinoma vascular endothelial-targeted polymeric nanomicelles with high magnetic resonance imaging (MRI) sensitivity and to evaluate their biological safety and in vitro tumor-targeting effect, and to monitor their feasibility using clinical MRI scanner. Method: Amphiphilic block copolymer, poly(ethylene glycol)- b -poly(ε-caprolactone) (PEG-PCL) was synthesized via the ring-opening polymerization of ε-caprolactone (CL) initiated by poly(ethylene glycol) (PEG), in which cyclic pentapeptide Arg-Gly-Asp (cRGD) was conjugated with the terminal of hydrophilic PEG block...
2018: International Journal of Medical Sciences
https://www.readbyqxmd.com/read/29559838/decellularized-hydrogels-in-bone-tissue-engineering-a-topical-review
#20
REVIEW
Andrea Pacifici, Luigi Laino, Marco Gargari, Federico Guzzo, Andrea Velandia Luz, Antonella Polimeni, Luciano Pacifici
Nowadays, autograft and allograft techniques represent the main solution to improve bone repair. Unfortunately, autograft technique is expensive, invasive and subject to infections and hematoma, frequently affecting both donor sites and surgical sites. A recent advance in tissue engineering is the fabrication of cell-laden hydrogels with custom-made geometry, depending on the clinical case. The use of ECM (Extra-Cellular Matrix)-derived Hydrogels from bone tissue is the new opportunity to obtain good results in bone regeneration...
2018: International Journal of Medical Sciences
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