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International Journal of Medical Sciences

Sen-Wei Tsai, Yi-Ju Hsu, Mon-Chien Lee, Hao-En Huang, Chi-Chang Huang, Yu-Tang Tung
Current treatment options for muscle injuries remain suboptimal and often result in delayed/incomplete recovery of damaged muscles. In this study, the effects of dextrose prolotherapy on inflammation and regeneration of skeletal muscles after a contusion injury were investigated. Mice were separated into five groups, including a normal control (NC), post-injury with no treatment (mass-drop injury, MDI), post-injury with 10% dextrose (MDI + 10% dextrose), post-injury with 20% dextrose (MDI + 20% dextrose), and post-injury with 30% dextrose (MDI + 30% dextrose)...
2018: International Journal of Medical Sciences
Linglu Jia, Weiting Gu, Yunpeng Zhang, Baoqi Jiang, Xu Qiao, Yong Wen
Objectives: To provide insight into the biological effects of activated Yes-associated protein (YAP) on the proliferation, apoptosis, and senescence of human periodontal ligament stem cells (h-PDLSCs). Methods: h-PDLSCs were isolated by the limiting dilution method, and their surface markers were quantified by flow cytometry. Enhanced green fluorescence protein (EGFP)-labeled lentiviral vector was used to activate YAP in h-PDLSCs, then qRT-PCR and Western blotting were used to evaluate the expression level of YAP...
2018: International Journal of Medical Sciences
Wen-Hsien Lee, Po-Chao Hsu, Chun-Yuan Chu, Szu-Chia Chen, Hung-Hao Lee, Ying-Chih Chen, Meng-Kuang Lee, Chee-Siong Lee, Hsueh-Wei Yen, Tsung-Hsien Lin, Wen-Chol Voon, Wen-Ter Lai, Sheng-Hsiung Sheu, Po-Lin Kuo, Ho-Ming Su
Aims: The renal systolic time intervals (STIs), including renal pre-ejection period (PEP), renal ejection time (ET), and renal PEP/renal ET measured by renal Doppler ultrasound, were associated with poor cardiac function and adverse cardiac outcomes. However, the relationship between renal hemodynamic parameters and arterial stiffness in terms of brachial-ankle pulse wave velocity (baPWV) has never been evaluated. The aim of this study was to assess the relationship between renal STIs and baPWV. Methods: This cross-sectional study enrolled 230 patients...
2018: International Journal of Medical Sciences
Pengcheng Li, Rui Huang, Tao Huang, Shuo Cheng, Yao Chen, Zhihang Wang
Aim: Long non-coding RNAs (LncRNAs) have been identified to play a crucial role in tumorigenesis and the progression of many types of tumors. However, the clinical significance and biological function of lncRNA nuclear-enriched abundant transcript 1(NEAT1) in human osteosarcoma remains unknown. Here, we investigated the role of NEAT1 in human osteosarcoma cell lines and clinical tumor samples. Methods: In this study, expression of NEAT1 was analyzed in 19 osteosarcoma tissues and paired adjacent non-tumor tissues by using quantitative real-time PCR...
2018: International Journal of Medical Sciences
Chun-Chung Chou, Yu-Chi Sung, Glen Davison, Chung-Yu Chen, Yi-Hung Liao
Background: Exercise-induced muscle damage during intensive sport events is a very common issue in sport medicine. Therefore, the purpose is to investigate the effects of short-term high-dose vitamin C and E supplementation on muscle damage, hemolysis, and inflammatory responses to simulated competitive Olympic Taekwondo (TKD) matches in elite athletes. Methods: Using a randomized placebo-controlled and double-blind study design, eighteen elite male TKD athletes were weight-matched and randomly assigned into either a vitamin C and E group (Vit C+E; N = 9) or placebo group (PLA; N = 9)...
2018: International Journal of Medical Sciences
Isabel Fuentes-Calvo, Ricardo Usategui-Martín, Ismael Calero-Paniagua, Cristina Moledo-Pouso, Luis García-Ortiz, Javier Del Pino-Montes, Rogelio González-Sarmiento, Carlos Martínez-Salgado
Paget´s disease of bone (PDB) is characterized by increased bone resorption followed by an excessive compensatory bone formation, with an abnormal bone structure with altered mechanical properties. Pagetic bone also has a higher vascularization and marrow fibrosis. Despite of pagetic bone being a highly vascularized tissue, there are no studies on the plasma levels of angiogenic mediators in the different states of the disease; moreover, the effect of PDB treatment on plasma levels of these angiogenic mediators is not very well known...
2018: International Journal of Medical Sciences
Byul Bo Ra Choi, Jeong Hae Choi, Jeong Ji, Ki Won Song, Hae June Lee, Gyoo Cheon Kim
Non-thermal plasma (NTP) has several beneficial effects, and can be applied as a novel instrument for skin treatment. Recently, many types of NTP have been developed for potential medical or clinical applications, but their direct effects on skin activation remain unclear. In this study, the effect of NTP on the alteration of mouse skin tissue was analyzed. After NTP treatment, there were no signs of tissue damage in mouse skin, whereas significant increases in epidermal thickness and dermal collagen density were detected...
2018: International Journal of Medical Sciences
Chih-Hung Guo, Wen-Long Chen, Chung-Huei Liao, Karin Huang, Pei-Yin Chen, Chun-Pai Yang
Background: Chinese medicinal formula BNG-1, a non-specific inhibitor of phospho-diesterases (PDEs), can be considered as a potential anti-inflammatory agent. The present study was aimed at determining the effects of BNG-1 on the development of non-alcoholic fatty liver disease (NAFLD) in mice. Design and Methods: Male CD1 mice were randomly divided into seven groups, the control Con (4) and Con (8)+saline groups were fed a standard control diet for four or eight weeks; the experimental HFD (4) and HFD (8)+saline groups were fed a high fat diet for four or eight weeks; the HFD (8)+LBNG, HFD (8)+MBNG, and HFD (8)+HBNG groups received a high fat diet along with low, moderate or high doses of BNG-1 (0...
2018: International Journal of Medical Sciences
Min-Che Tung, Yu-Ching Wen, Shian-Shiang Wang, Yung-Wei Lin, Yu-Cheng Liu, Shun-Fa Yang, Ming-Hsien Chien
Dopamine receptor D2 (DRD2) is overexpressed in several kinds of cancers and was correlated with the prognosis of these cancers. Polymorphisms within the DRD2 gene were shown to be associated with lung and colon cancers. The purpose of this study was to explore effects of DRD2 gene polymorphisms on the susceptibility to and clinicopathological characteristics of urothelial cell carcinoma (UCC). In total, 369 patients diagnosed with UCC and 738 healthy controls were enrolled to analyze DRD2 genotypes at four loci (rs1799732, -141C>del; rs1079597, TaqIB; rs6277, 957C>T; and rs1800497, TaqIA) using a TaqMan-based real-time polymerase chain reaction (PCR)...
2018: International Journal of Medical Sciences
Gui-Nv Hu, Huey-En Tzeng, Po-Chun Chen, Chao-Qun Wang, Yong-Ming Zhao, Yan Wang, Chen-Ming Su, Chih-Hsin Tang
Breast cancer is a major cause of cancer mortality amongst women. Chemokine (C-C motif) ligand 4 is encoded by the CCL4 gene; specific CCL4 gene polymorphisms are related to the risks and prognoses of various diseases. In this study, we examined whether CCL4 gene single nucleotide polymorphisms (SNPs) predict the risk and progression of breast cancer. Between 2014 and 2016, we recruited 314 patients diagnosed with breast cancer and a cohort of 209 healthy participants (controls) without a history of cancer...
2018: International Journal of Medical Sciences
Tzu-Ju Chen, Hong-Lin He, Yow-Ling Shiue, Ching-Chieh Yang, Li-Ching Lin, Yu-Feng Tian, Shang-Hung Chen
Background: Concurrent chemoradiotherapy (CCRT) has now become the standard of treatments for advanced rectal cancer before surgery. To search the biological molecules with prognostic and therapeutic potential of CCRT could be beneficial for these patients. Recently, aberrant expression of chloride channels has been linked to radio-resistance in glioblastoma; however, its clinical implication has not been well-studied in rectal cancers. Therefore, we examined the clinical significance of targetable drivers associated with chloride channel activity in patients with rectal cancer receiving CCRT...
2018: International Journal of Medical Sciences
Jung-Suk Bok, Sung-Hoon Byun, Bong-Wook Park, Young-Hoon Kang, Sung-Lim Lee, Gyu-Jin Rho, Sun-Chul Hwang, Dong Kyun Woo, Hyeon-Jeong Lee, June-Ho Byun
Angiogenesis and vascularization are essential for the growth and survival of most tissues. Engineered bone tissue requires an active blood vessel network for survival and integration with mature host tissue. Angiogenesis also has an effect on cell growth and differentiation in vitro . However, the effect of angiogenic factors on osteoprogenitor cell differentiation remains unclear. We studied the effects of human umbilical vein endothelial cells (HUVECs) on osteogenic differentiation of dental follicle-derived stem cells (DFSCs) in vitro by co-culturing DFSCs and HUVECs...
2018: International Journal of Medical Sciences
Nan Nwe Win, Tatsuo Kanda, Shingo Nakamoto, Mitsuhiko Moriyama, Xia Jiang, Akiko Suganami, Yutaka Tamura, Hiroaki Okamoto, Hiroshi Shirasawa
Hepatitis A virus (HAV) infection is one of the major causes of acute hepatitis and acute liver failure in developing and developed countries. Although effective vaccines for HAV infection are available, outbreaks of HAV infection still cause deaths, even in developed countries. One approach to control HAV infection is prevention through diet, which can inhibit HAV propagation and replication. Glucose-regulated protein 78 (GRP78) is a member of the heat shock protein 70 family of molecular chaperone required for endoplasmic reticulum stress and stress-induced autophagy...
2018: International Journal of Medical Sciences
Pinn Tsin Isabel Yee, Chit Laa Poh
Enterovirus 71 (EV-A71) is one of the major pathogens causing hand, foot and mouth disease (HFMD). Some strains can lead to neurological disease and fatality in children. Up to date, there is no FDA-approved vaccine to prevent severe HFMD and mortality. Although the inactivated vaccine has advanced to production in China, lack of long-term protection and the requirement of multiple boosters have necessitated the development of other types of vaccines. Recent studies indicate that cellular and not humoral immunity determines the clinical outcome of EV-A71 infections...
2018: International Journal of Medical Sciences
Yi-Jen Chen, Wei-An Chang, Ling-Yu Wu, Ya-Ling Hsu, Chia-Hsin Chen, Po-Lin Kuo
Cartilage destruction in rheumatoid arthritis (RA) occurs primarily in the pannus-cartilage interface. The close contact of the synovium-cartilage interface implicates crosstalk between synovial fibroblasts and chondrocytes. The aim of this study is to explore the differentially expressed genes and novel microRNA regulations potentially implicated in the dysregulated cartilage homeostasis in joint destruction of RA. Total RNAs were extracted from human primary cultured normal and RA chondrocytes for RNA and small RNA expression profiling using next-generation sequencing...
2018: International Journal of Medical Sciences
Qing Zhang, Jicheng Chen, Hanchao Gao, Song Zhang, Chengjiang Zhao, Cuibing Zhou, Chengjun Wang, Yang Li, Zhiming Cai, Lisha Mou
Long-term administration of classic immunosuppressants can induce severe adverse effects. The development of novel immunosuppressants confronts great challenges and opportunities. Ibrutinib, an approved drug for B-cell lineages and chronic graft versus host disease (cGVHD), exhibits immunosuppressive efficacy in autoimmune diseases. Ibrutinib's potential as an immunosuppressant in organ transplantation has not been investigated to date. In a xeno-artery patch model ex vivo , ibrutinib inhibited the proliferation of PBMCs (POD 14-42), mainly CD3+ CD4+ and CD3+ CD8+ T cells ex vivo ...
2018: International Journal of Medical Sciences
Péter Kustán, Tamás Kőszegi, Attila Miseta, Iván Péter, Zénó Ajtay, István Kiss, Balázs Németh
Background : Psoriasis is one of the most common chronic, life-long dermatologic diseases, which has considerable negative effects on quality of life. Psoriasis is considered as a systemic inflammatory disease, thus acute phase proteins such as C-reactive protein (CRP) and orosomucoid (ORM) have been shown to play a role in its pathophysiology. This study was aimed to compare CRP, serum ORM (se-ORM) and urinary ORM (u-ORM) levels of psoriatic patients to healthy individuals. Methods : 87 psoriatic patients and 41 healthy individuals were enrolled...
2018: International Journal of Medical Sciences
Jakub Taradaj, Barbara Shay, Robert Dymarek, Mirosław Sopel, Karolina Walewicz, Dimitri Beeckman, Lisette Schoonhoven, Amit Gefen, Joanna Rosińczuk
Objective: To evaluate the effect of laser irradiation at different wavelengths on the expression of selected growth factors and inflammatory mediators at particular stages of the wound healing process. Methods: Sixty-seven patients were recruited, treated, and analyzed (group A - 940 nm: 17 patients; group B - 808 nm: 18 patients; group C - 658 nm: 16 patients; group D - sham therapy: 17 patients). Patients received a basic treatment, including repositioning and mobilization, air pressure mattress and bed support surfaces, wound cleansing and drug therapy...
2018: International Journal of Medical Sciences
Zhiyan Xu, Tao Wang, Xiaoxiao Guo, Yao Li, Yi Hu, Chao Ma, Jing Wang
Background : The relationship of serum antigen-specific immunoglobulin E (IgE) with cardiovascular diseases (CVDs) remains poorly understood. This study aimed to explore the association of antigen-specific and total IgE with CVDs using data derived from the National Health and Nutrition Examination Survey (NHANES) 2005-2006. Methods and Results : The association of serum total or antigen-specific IgE levels with CVDs was analyzed by survey-weighted logistic regression modeling, adjusted by age, sex, race, education, body mass index, blood pressure, total cholesterol, C-reactive protein, homocysteine, diabetes, smoking, and alcohol consumption...
2018: International Journal of Medical Sciences
Ping Guo, Yujin Pan, Yuan Zhang, Sean Tighe, Yingting Zhu, Ming Li, Xiaoli Shen, Baotao Lin, Binghong Pan, Xinhua Liu, Hongbo Cheng
In this article, the significance of anterior segment optical coherence tomography (AS-OCT) to aid the clinical diagnosis and treatment of Descemet membrane (DM) detachment after phacoemulsification combined with intraocular lens implantation was retrospectively analyzed using 26 patients (26 eyes). The location and scope of DM detachment, its causative factors and the percentage of each detachment type are considered for clinical treatments. Based on the location and scope, the detachment can be divided into three types: (1) simple, (2) symmetrical and (3) complete DM detachment...
2018: International Journal of Medical Sciences
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