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International Journal of Medical Sciences

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https://www.readbyqxmd.com/read/29104488/cancer-stem-cell-gene-variants-predict-disease-recurrence-in-patients-treated-with-radical-prostatectomy-for-prostate-cancer
#1
Victor C Lin, Shu-Pin Huang, Chao-Yuan Huang, Chia-Cheng Yu, Hsin-Ling Yin, Tsung-Yi Huang, Cheng-Hsueh Lee, Te-Ling Lu, Bo-Ying Bao
Background: Cancer stem cells (CSCs) are involved in tumor progression and drug resistance. We hypothesized that variants in CSC marker genes influence treatment outcomes in prostate cancer. Methods: Ten potentially functional single nucleotide polymorphisms (SNPs) in seven prostate CSC marker genes, TACSTD2, PROM1, ITGA2, POU5F1, EZH2, PSCA, and CD44, were selected for analysis of their association with disease recurrence by Kaplan-Meier analysis and Cox regression in a cohort of 320 patients with localized prostate cancer receiving radical prostatectomy...
2017: International Journal of Medical Sciences
https://www.readbyqxmd.com/read/29104487/ier5-is-involved-in-dna-double-strand-breaks-repair-in-association-with-papr1-in-hela-cells
#2
Xin-Ping Yu, Yu-Mei Wu, Yang Liu, Ming Tian, Jian-Dong Wang, Ku-Ke Ding, Teng Ma, Ping-Kun Zhou
The immediate early response gene 5 (IER5) is a radiation response gene induced in a dose-independent manner, and has been suggested to be a molecular biomarker for biodosimetry purposes upon radiation exposure. Here, we investigated the function of IER5 in DNA damage response and repair. We found that interference on IER5 expression significantly decreased the efficiency of repair of DNA double-strand breaks induced by ionizing radiations in Hela cells. We found that IER5 participates in the non-homologous end-joining pathway of DNA breaks repair...
2017: International Journal of Medical Sciences
https://www.readbyqxmd.com/read/29104486/tanshinone-iia-inhibits-%C3%AE-catenin-nuclear-translocation-and-igf-2r-activation-via-estrogen-receptors-to-suppress-angiotensin-ii-induced-h9c2-cardiomyoblast-cell-apoptosis
#3
Ya-Fang Chen, Cecilia Hsuan Day, Nien-Hung Lee, Yu-Feng Chen, Jaw-Ji Yang, Chih-Hsueh Lin, Ray-Jade Chen, Peramaiyan Rajendran, Vijaya Padma Viswanadha, Chih-Yang Huang
Cardiomyopathy involves changes in the myocardial ultra-structure, hypertrophy, apoptosis, fibrosis and inflammation. Angiotensin II (AngII) stimulates the expression of insulin like-growth factors (IGF-2) and IGF-2 receptor (IGF-2R) in H9c2 cardiomyoblasts and subsequently leads to apoptosis. Estrogen receptors protect cardiomyocytes from apoptosis and fibrosis. Tanshinone IIA (TSN), a main active ingredient from Danshen, has been shown to protect cardiomyocytes from death caused by different stress signals...
2017: International Journal of Medical Sciences
https://www.readbyqxmd.com/read/29104485/cell-recognition-molecule-l1-regulates-cell-surface-glycosylation-to-modulate-cell-survival-and-migration
#4
Gang Shi, Yue Du, Yali Li, Yue An, Zhenwei He, Yingwei Lin, Rui Zhang, Xiaofei Yan, Jianfeng Zhao, Shihua Yang, Pang Nghee Kheem Brendan, Fang Liu
Background: Cell recognition molecule L1 (L1) plays an important role in cancer cell differentiation, proliferation, migration and survival, but its mechanism remains unclear. Methodology/Principal: Our previous study has demonstrated that L1 enhanced cell survival and migration in neural cells by regulating cell surface glycosylation. In the present study, we show that L1 affected cell migration and survival in CHO (Chinese hamster ovary) cell line by modulation of sialylation and fucosylation at the cell surface via the PI3K (phosphoinositide 3-kinase) and Erk (extracellularsignal-regulated kinase) signaling pathways...
2017: International Journal of Medical Sciences
https://www.readbyqxmd.com/read/29104484/chlorpheniramine-attenuates-histamine-mediated-aquaporin-5-downregulation-in-human-nasal-epithelial-cells-via-suppression-of-nf-%C3%AE%C2%BAb-activation
#5
Yung-Lung Chang, Chun-Shu Lin, Hsing-Won Wang, Kai Ren Jian, Shao-Cheng Liu
Background: Aquaporin 5 (AQP5) is most likely the primary water channel in the human nasal mucosa and acts as a key tight junction protein. The signaling cascades responsible for AQP5 regulation are still works in progress. Objective: This study sought to determine the effects of histamine and chlorpheniramine on AQP5 expression in human nasal epithelial cells (HNEpC) and to detect the signaling cascades responsible for these effects. Methods: HNEpC were cultured with four concentrations of histamine or chlorpheniramine in vitro...
2017: International Journal of Medical Sciences
https://www.readbyqxmd.com/read/29104483/overexpression-of-endothelial-cell-specific-molecule-1-correlates-with-gleason-score-and-expression-of-androgen-receptor-in-prostate-carcinoma
#6
Chung-Yu Lai, Chien-Min Chen, Wen-Hung Hsu, Yi-Hsien Hsieh, Chung-Jung Liu
Endothelial cell-specific molecule 1 (ESM1) is a major prognostic marker of several tumor types, but its value as a marker for prostate cancer is unknown. The purpose of the present study was to measure the relationship of ESM1 expression with androgen receptor (AR) expression and with Gleason score in human prostate carcinoma tissue. Expression of ESM1 and AR were determined by immunohistochemical staining of prostate tissues from healthy individuals and patients with prostate cancer. The results showed that ESM1 expression was significantly higher in prostate tumor tissues than in normal prostate tissues (p < 0...
2017: International Journal of Medical Sciences
https://www.readbyqxmd.com/read/29104482/human-cartilage-engineering-in-an-in-vitro-repair-model-using-collagen-scaffolds-and-mesenchymal-stromal-cells
#7
Clara Sanjurjo-Rodríguez, Rocío Castro-Viñuelas, Tamara Hermida-Gómez, Isaac Manuel Fuentes-Boquete, Francisco Javier de Toro, Francisco Javier Blanco, Silvia María Díaz-Prado
The purpose of this study was to investigate cartilage repair of in vitro lesion models using human bone marrow mesenchymal stromal cells (hBMSCs) with different collagen (Col) scaffolds. Lesions were made in human cartilage biopsies. Injured samples were pre-treated with interleukin 1β (IL1β) for 24 h; also, samples were not pre-treated. hBMSCs were seeded on different types of collagen scaffolds. The resulting constructs were placed into the lesions, and the biopsies were cultured for 2 months in chondrogenic medium...
2017: International Journal of Medical Sciences
https://www.readbyqxmd.com/read/29104481/an-application-of-ngs-for-wdr36-gene-in-taiwanese-patients-with-juvenile-onset-open-angle-glaucoma
#8
Hsuan-An Su, Shuan-Yow Li, Jiann-Jou Yang, Yung-Chang Yen
Primary open-angle glaucoma (POAG) is one of the most important disease in ophthalmology with high prevalence and risk of irreversible blindness. If diagnosed before the age of 35, it is usually categorized as juvenile open-angle glaucoma (JOAG). The WDR36 gene is reckoned as one of the major causative genes of POAG, and had been studied to be related to the pathogenesis of POAG in the literature. We have selected 61 JOAG patients and 61 JOAG-free individuals, and by next-generation sequencing method, the WDR36 gene of the subjects were analyzed...
2017: International Journal of Medical Sciences
https://www.readbyqxmd.com/read/29104480/heart-failure-and-mortality-of-adult-survivors-from-acute-myocarditis-requiring-intensive-care-treatment-a-nationwide-cohort-study
#9
Jung-Jung Chang, Ming-Shyan Lin, Tien-Hsing Chen, Dong-Yi Chen, Shao-Wei Chen, Jen-Te Hsu, Po-Chang Wang, Yu-Sheng Lin
Background The correlation between severity and long-term outcomes of pediatric myocarditis have been reported, however this correlation in adults has rarely been studied. Materials and Methods This nationwide population-based cohort study used data from the National Health Insurance Research Database in Taiwan. Patients aged < 75 and > 18 years admitted to an intensive care unit due to acute myocarditis were enrolled and divided into three groups according to mechanical circulatory support (MCS) after excluding major comorbidities...
2017: International Journal of Medical Sciences
https://www.readbyqxmd.com/read/29104479/knockdown-of-yes-associated-protein-induces-the-apoptosis-while-inhibits-the-proliferation-of-human-periodontal-ligament-stem-cells-through-crosstalk-between-erk-and-bcl-2-signaling-pathways
#10
Yong Wen, Yawen Ji, Yunpeng Zhang, Baoqi Jiang, Cuizhu Tang, Qi Wang, Xiyan Chen, Linglu Jia, Weiting Gu, Xin Xu
Objective: The purpose of this study was to provide an insight into the biological effects of knockdown Yes-associated protein (YAP) on the proliferation and apoptosis of human periodontal ligament stem cells (h-PDLSCs). Methods: Immunofluorescence and Western blot were used to evaluate Hippo-YAP signaling expression level. Enhanced green fluorescence protein lentiviral vector was constructed to down-regulate YAP in h-PDLSCs. Real-time quantitative reverse transcription polymerase chain reaction (qRT-PCR) and Western blot were used to detect the interfering efficiency of YAP expression...
2017: International Journal of Medical Sciences
https://www.readbyqxmd.com/read/29104478/extracorporeal-shockwave-therapy-enhances-expression-of-pdia-3-which-is-a-key-factor-of-the-1%C3%AE-25-dihydroxyvitamin-d-3-rapid-membrane-signaling-pathway-in-treatment-of-early-osteoarthritis-of-the-knee
#11
Shan-Ling Hsu, Jai-Hong Cheng, Ching-Jen Wang, Jih-Yang Ko, Chih-Hsiang Hsu
The goal of our research was demonstrated that multiple molecules in microenvironments of the early osteoarthritis (OA) joint tissue may be actively responded to extracorporeal shockwave therapy (ESWT) treatment, which potentially regulated biological function of chondrocytes and synovial cells in early OA knee. We demonstrated that shockwave treatment induced the expression of protein-disulfide isomerase-associated 3 (Pdia-3) which was a significant mediator of the 1α,25-Dihydroxyvitamin D 3 (1α,25(OH)2D3) rapid signaling pathway, using two-dimensional electrophoresis, histological analysis and quantitative polymerase chain reaction (qPCR)...
2017: International Journal of Medical Sciences
https://www.readbyqxmd.com/read/29104477/water-soluble-vitamins-enhance-the-growth-of-microorganisms-in-peripheral-parenteral-nutrition-solutions
#12
Sachiko Omotani, Katsuji Tani, Katsuhito Nagai, Yasutoshi Hatsuda, Junji Mukai, Michiaki Myotoku
Peripheral parenteral nutrition (PPN) solutions contain amino acids, glucose, and electrolytes, with or without some water soluble vitamins. Peripheral venous catheters are one of the causes of catheter related blood stream infection (CRBSI), which requires infection control. In Japan, PPN solutions have rarely been prepared under aseptic conditions. However, in recent years, the necessity of adding vitamins to infusions has been reported. Therefore, we investigated the effects of water soluble vitamins on growth of microorganisms in PPN solutions...
2017: International Journal of Medical Sciences
https://www.readbyqxmd.com/read/29104476/glp-1-treatment-improves-diabetic-retinopathy-by-alleviating-autophagy-through-glp-1r-erk1-2-hdac6-signaling-pathway
#13
Xiangsheng Cai, Jingjing Li, Mingzhu Wang, Miaoqin She, Yongming Tang, Jinlong Li, Hongwei Li, Hongxiang Hui
Objective: Apoptosis and autophagy of retinal cells, which may be induced by oxidative stress, are tightly associated with the pathogenesis of diabetic retinopathy (DR). The autophagy induced by oxidative stress is considered as excessively stimulated autophagy, which accelerates the progression of DR. This study aims to investigate the protective effect of GLP-1 treatment on alleviating apoptosis and autophagy of retinal cells in type 2 diabetic rats and reveals its possible mechanism. Methods: Type 2 diabetic rats were induced by fed with high sugar, high fat diet and followed with streptozotocin injection...
2017: International Journal of Medical Sciences
https://www.readbyqxmd.com/read/29104475/association-of-hmgb1-gene-polymorphisms-with-lung-cancer-susceptibility-and-clinical-aspects
#14
Weiwei Hu, Po-Yi Liu, Yi-Chen Yang, Po-Chun Chen, Chen-Ming Su, Chia-Chia Chao, Chih-Hsin Tang
Lung cancer is one of the most frequently diagnosed malignancies and is associated with a poor survival rate in the Chinese Han population. Analysis of genetic variants could lead to improvements in prognosis following lung cancer therapy. High-mobility group box 1 protein (HMGB1) is a ubiquitous nuclear protein found in eukaryotic cells that participates in several biological functions including immune response, cell survival, apoptosis and cancer development. We investigated the effects of HMGB1 gene polymorphisms on the risk of lung cancer progression in a Chinese Han population...
2017: International Journal of Medical Sciences
https://www.readbyqxmd.com/read/29104474/association-of-surfactant-protein-with-expression-of-hoxa5-and-hoxb5-in-rabbit-fetal-lung
#15
Sung-Hoon Chung, Chong-Woo Bae
Hox genes regulate organ formation and identity of the embryo, and expressed in specific temporo-spatial patterns in the developing embryo. We compared the expression levels of the Hoxa5, Hoxb5, surfactant protein (SP)-A, and SP-B genes in immature and mature rabbit fetal lung tissues, and to uncover roles for Hoxa5, Hoxb5, SP-A, and SP-B. Cesarean sections were performed after rabbits were divided into two groups of 30-31 days of gestation (term group, n = 24) and 26-27 days of gestation (preterm group, n = 24)...
2017: International Journal of Medical Sciences
https://www.readbyqxmd.com/read/29104473/the-inhibition-of-indoleamine-2-3-dioxygenase-1-by-connexin-43
#16
Han-Chen Lin, Chih-Jen Yang, Yu-Diao Kuan, Wei-Kuang Wang, Wen-Wei Chang, Che-Hsin Lee
Upregulation of connexin 43 (Cx43) showed potential in enhancing immune surveillance that was suppressed in the tumor microenvironment. The expression of indoleamine 2, 3-dioxygenase (IDO) is one of the crucial factors contributing to tumor immune tolerance by depletion of tryptophan and IDO-mediated tryptophan metabolites. Here, we aim to investigate the role of Cx43 in IDO production in murine tumor by using Cx43 inducers. Resveratrol (trans-3, 5, 4 '-trihydroxystilbene) is a natural plant-derived polyphenol possessing positive effect against cancer...
2017: International Journal of Medical Sciences
https://www.readbyqxmd.com/read/29104472/emmprin-inhibits-bfgf-induced-il-6-secretion-in-an-osteoblastic-cell-line-mc3t3-e1
#17
Akari Saiki, Mitsuru Motoyoshi, Keiko Motozawa, Teinosuke Okamura, Kousuke Ueki, Noriyoshi Shimizu, Masatake Asano
Background: Electrolytically-generated acid functional water (FW) is obtained by electrolyzing low concentrations of saline. Although it has been widely used in clinical practice with various purposes, the underlying mechanisms of action involved have not been fully elucidated so far. We used the human cervical cancer-derived fibroblastic cell line (HeLa), to examine the cytokine secretion profile following FW treatment in the present study. Results: FW stimulation significantly induced the secretion of basic fibroblast growth factor (bFGF) and extracellular matrix metalloproteinase inducer (EMMPRIN)...
2017: International Journal of Medical Sciences
https://www.readbyqxmd.com/read/29104471/neonatal-lipopolysaccharide-exposure-gender-dependently-increases-heart-susceptibility-to-ischemia-reperfusion-injury-in-male-rats
#18
Peng Zhang, Juanxiu Lv, Yong Li, Lubo Zhang, Daliao Xiao
Background: Adverse stress exposure during the early neonatal period has been shown to cause aberrant development, resulting in an increased risk of adult disease. We tested the hypothesis that neonatal exposure to lipopolysaccharide (LPS) does not alter heart function at rest condition but causes heart dysfunction under stress stimulation later in life. Methods: Saline control or LPS were administered to neonatal rats via intraperitoneal injection. Experiments were conducted in 6 week-old male and female rats...
2017: International Journal of Medical Sciences
https://www.readbyqxmd.com/read/29104470/critical-role-of-p53-and-k-ras-in-the-diagnosis-of-early-colorectal-cancer-a-one-year-single-center-analysis
#19
Hui-Ying Lu, Ri-Tian Lin, Guang-Xi Zhou, Tian-Ming Yu, Zhan-Ju Liu
Background: Colorectal cancer (CRC) is strongly associated with colorectal polyps, which has become the third most common cancer in China. In the present study, we revealed the susceptible population and risk factors of colorectal polyps, and analyzed the expression of Ki-67, p53 and K-ras in the intestinal mucosa of patients with colorectal polyps in order to explore their significance in the detection and prognosis of CRC at an early stage. Materials and Methods: Total 801 cases of colorectal polyps were collected during endoscopic resection including endoscopic mucosal resection (EMR) and endoscopic submucosal dissection (ESD)...
2017: International Journal of Medical Sciences
https://www.readbyqxmd.com/read/29104469/mef2c-loss-of-function-mutation-contributes-to-congenital-heart-defects
#20
Xiao-Hui Qiao, Fei Wang, Xian-Ling Zhang, Ri-Tai Huang, Song Xue, Juan Wang, Xing-Biao Qiu, Xing-Yuan Liu, Yi-Qing Yang
Congenital heart disease (CHD) is the most common type of developmental abnormality in humans, and is a leading cause for substantially increased morbidity and mortality in affected individuals. Increasing studies demonstrates a pivotal role of genetic defects in the pathogenesis of CHD, and presently mutations in more than 60 genes have been associated with CHD. Nevertheless, CHD is of pronounced genetic heterogeneity, and the genetic basis underpinning CHD in a large proportion of patients remains unclear...
2017: International Journal of Medical Sciences
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