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International Journal of Medical Sciences

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https://www.readbyqxmd.com/read/28090190/expression-of-the-receptor-activator-of-nuclear-factor-kb-ligand-in-peripheral-blood-mononuclear-cells-in-patients-with-acute-charcot-neuroarthropathy
#1
Alberto Bergamini, Francesca Bolacchi, Caterina Delfina Pesce, Giada Veneziano, Luigi Uccioli, Valentina Girardi, Laura De Corato, Maria Teresa Mondillo, Ettore Squillaci
Introduction. The receptor activator of nuclear factor-kB (RANK), ligand (RANK-L) and osteoprotegerin (OPG) are implicated in the pathogenesis of acute Charcot neuroarthropathy (CN). Materials and Methods. This study aimed to investigate the expression of RANK-L and OPG in peripheral blood mononuclear cells (PBMC) from patients with acute CN. Results. We found that the expression of RANK-L was lower in patients with acute CN as compared with diabetic control subjects and healthy control participants; whereas OPG expression was not detected in patients and in both control groups...
2016: International Journal of Medical Sciences
https://www.readbyqxmd.com/read/27994505/pulsed-radiofrequency-attenuates-diabetic-neuropathic-pain-and-suppresses-formalin-evoked-spinal-glutamate-release-in-rats
#2
Yu-Hsin Huang, Shao-Yun Hou, Jen-Kun Cheng, Chih-Hsien Wu, Chung-Ren Lin
BACKGROUND: Pulsed radiofrequency (PRF) has been used to treat chronic pain for years, but its effectiveness and mechanism in treating diabetic neuropathic pain are still unexplored. The aim of this study was to elucidate the modulation of diabetic neuropathic pain induced by streptozotocin and the release of spinal excitatory amino acids by PRF. METHODS: Diabetes was induced by intraperitoneal administration of streptozotocin. Pulsed radiofrequency was applied to L5 and L6 dorsal roots at 42 °C for 2 min...
2016: International Journal of Medical Sciences
https://www.readbyqxmd.com/read/27994504/genetic-analysis-of-bdnf-gnb3-mthfr-ace-and-apoe-variants-in-major-and-recurrent-depressive-disorders-in-russia
#3
E A Bondarenko, M I Shadrina, M N Grishkina, T A Druzhkova, R G Akzhigitov, N V Gulyaeva, A B Guekht, P A Slominsky
This study was conducted to explore the possibility of association between the single-nucleotide polymorphisms rs6264 of BDNF, rs5443 of GNB3, and rs1801133 of MTHFR; the In/Del polymorphism of ACE; and the ε2 allele of APOE and major depressive disorder (MDD) and recurrent depressive disorder (RDD) in an East Slavic population. Generalized multifactor dimensionality reduction (GMDR) method was applied to detect gene-gene interactions. One hundred fifty patients with RDD (101 females and 49 males) and 208 patients with MDD (115 females and 93 males) were included in the study...
2016: International Journal of Medical Sciences
https://www.readbyqxmd.com/read/27994503/association-of-far-infrared-radiation-therapy-and-ankle-brachial-index-of-patients-on-hemodialysis-with-peripheral-artery-occlusive-disease
#4
Szu-Chia Chen, Mei-Yueh Lee, Jiun-Chi Huang, I-Ching Kuo, Hsiu-Chin Mai, Po-Lin Kuo, Jer-Ming Chang, Shang-Jyh Hwang, Hung-Chun Chen
Background and Aim: The ankle-brachial index (ABI) is recognized to be a good marker for atherosclerosis, and is useful in the diagnosis of peripheral artery occlusive disease (PAOD) which is prevalent among patients on hemodialysis (HD). Methods: This randomized trial aimed to evaluate the effect of far-infrared radiation (FIR) therapy on ABI in HD patients with PAOD. PAOD was defined as patients with ABI < 0.95. One hundred and eight HD patients were enrolled, including 50 in the control group and 58 in the FIR group...
2016: International Journal of Medical Sciences
https://www.readbyqxmd.com/read/27994502/decreased-tumor-suppressor-candidate-3-predicts-poor-prognosis-of-patients-with-esophageal-squamous-cell-carcinoma
#5
Xinshuang Yu, Jiandong Zhang, Hua Zhong, Fengjun Liu, Ning Liang, Yao Wang, Xiangjiao Meng, Juan Du
TUSC3 was recently identified as a potential tumor suppressor gene in a variety of human malignancies. However, no data are currently available regarding the expressions of TUSC3 in esophageal cancer (ESCC).The purposes of this study was to investigated the expressions of TUSC3 in ESCC tissues and assess the relationship between TUSC3 levels and clinico-pathological characteristics of ESCC patients. TUSC3 protein expressions were evaluated by immunohistochemistry (IHC) on tissue microarray slides in esophageal cancer, which included 95 esophageal squamous carcinoma specimens (ESCC), and 75 normal esophageal mucosa (NEM)...
2016: International Journal of Medical Sciences
https://www.readbyqxmd.com/read/27994501/blockade-of-central-glp-1-receptors-deteriorates-the-improvement-of-diabetes-after-ileal-transposition
#6
Weijie Chen, Qianqian Xu, Yiding Xiao, Jiaolin Zhou, Weimin Zhang, Guole Lin, Fengying Gong
Background: The mechanism of improvement of type 2 diabetes mellitus induced by ileal transposition (IT) is undefined. Our aim was to investigate the possible role of central glucagon-like peptide 1 (GLP-1) after IT. Methods: Ninety male diabetic rats were randomly divided into the IT, sham IT (S-IT) and control group. The food intake, glucose metabolism and GLP-1 level were measured. Subsequently, we administered GLP-1 antagonist via lateral brain ventricle cannula to block central GLP-1 receptor, and verified whether the food intake, glucose metabolism changed...
2016: International Journal of Medical Sciences
https://www.readbyqxmd.com/read/27994500/resveratrol-alleviate-hypoxic-pulmonary-hypertension-via-anti-inflammation-and-anti-oxidant-pathways-in-rats
#7
Dunquan Xu, Yan Li, Bo Zhang, Yanxia Wang, Yi Liu, Ying Luo, Wen Niu, Mingqing Dong, Manling Liu, Haiying Dong, Pengtao Zhao, Zhichao Li
Resveratrol, a plant-derived polyphenolic compound and a phytoestrogen, was shown to possess multiple protective effects including anti-inflammatory response and anti-oxidative stress. Hypoxic pulmonary hypertension (HPH) is a progressive disease characterized by sustained vascular resistance and marked pulmonary vascular remodeling. The exact mechanisms of HPH are still unclear, but inflammatory response and oxidative stress was demonstrated to participate in the progression of HPH. The present study was designed to investigate the effects of resveratrol on HPH development...
2016: International Journal of Medical Sciences
https://www.readbyqxmd.com/read/27994499/adhesion-prevention-efficacy-of-composite-meshes-parietex-%C3%A2-proceed-%C3%A2-and-4dryfield-%C3%A2-ph-covered-polypropylene-meshes-in-an-ipom-rat-model
#8
Markus Winny, Lavinia Maegel, Leonie Grethe, Torsten Lippmann, Danny Jonigk, Harald Schrem, Alexander Kaltenborn, Juergen Klempnauer, Daniel Poehnert
Background: Adhesions to intraperitoneally implanted meshes (IPOM) are a common problem following hernia surgery and may cause severe complications. Recently, we showed that missing peritoneal coverage of the intestine is a decisive factor for adhesion formation and 4DryField(®) PH (4DF) gel significantly prevents intestine-to-mesh adhesions even with use of uncoated Ultrapro(®) polypropylene mesh (UPM). The present study investigates adhesion prevention capability of coated Parietex(®) mesh (PTM) and Proceed(®) mesh (PCM) in comparison to 4DF treated UPM...
2016: International Journal of Medical Sciences
https://www.readbyqxmd.com/read/27994498/association-between-survivin-genetic-polymorphisms-and-epidermal-growth-factor-receptor-mutation-in-non-small-cell-lung-cancer
#9
Tu-Chen Liu, Ming-Ju Hsieh, Wen-Jun Wu, Ying-Erh Chou, Whei-Ling Chiang, Shun-Fa Yang, Shih-Chi Su, Thomas Chang-Yao Tsao
Survivin is an anti-apoptotic protein that is implicated in the regulation of apoptosis and cell cycle in various types of cancers. The current study explored the effect of survivin gene polymorphisms and EGFR mutations in non-small-cell lung carcinoma (NSCLC) patients. A total of 360 participants, including 291 adenocarcinoma lung cancer and 69 squamous cell carcinoma lung cancer patients, were selected for the analysis of three survivin genetic variants (survivin -31, +9194, and +9809) by using real-time PCR genotyping...
2016: International Journal of Medical Sciences
https://www.readbyqxmd.com/read/27994497/menthol-inhibiting-parasympathetic-function-of-tracheal-smooth-muscle
#10
Hsing-Won Wang, Shao-Cheng Liu, Pin-Zhir Chao, Fei-Peng Lee
Menthol is used as a constituent of food and drink, tobacco and cosmetics nowadays. This cold receptor agonist has been used as a nasal inhalation solution in the daily life. The effect of menthol on nasal mucosa in vivo is well known; however, the effect of the drug on tracheal smooth muscle has been rarely explored. Therefore, during administration of the drug for nasal symptoms, it might also affect the trachea via oral intake or inhalation. We used our preparation to test the effectiveness of menthol on isolated rat tracheal smooth muscle...
2016: International Journal of Medical Sciences
https://www.readbyqxmd.com/read/27994496/overexpression-of-lncrna-h19-mir-675-promotes-tumorigenesis-in-head-and-neck-squamous-cell-carcinoma
#11
Guo-Fang Guan, De-Jun Zhang, Lian-Ji Wen, Ding Xin, Yan Liu, Duo-Jiao Yu, Kai Su, Lin Zhu, Ying-Yuan Guo, Ke Wang
There is accumulating evidence indicating that long non-coding RNA H19 and its mature product miR-675 play essential roles for tumor growth and progression. However, their prognostic value in human head and neck squamous cell carcinoma (HNSCC), particular in laryngeal carcinoma, remains to be elucidated. In this study, we observed that both H19 and miR-675 were significantly overexpressed in a cohort of 65 primary tumor samples and two HNSCC cell lines. Importantly, when paired with patient follow-up data, higher expression of either H19 or miR-675 was significantly correlated with higher risk of patient relapse, and associated with worse overall survival and poor disease-free survival...
2016: International Journal of Medical Sciences
https://www.readbyqxmd.com/read/27994495/circulating-tumor-cells-and-circulating-tumor-dna-provide-new-insights-into-pancreatic-cancer
#12
REVIEW
Yang Gao, Yayun Zhu, Zhou Yuan
Pancreatic cancer has a rather dismal prognosis mainly due to high malignance of tumor biology. Up to now, the relevant researches on pancreatic cancer lag behind seriously partly due to the obstacles for tissue biopsy, which handicaps the understanding of molecular and genetic features of pancreatic cancer. In the last two decades, liquid biopsy, including circulating tumor cells (CTCs) and circulating tumor DNA (ctDNA), is promising to provide new insights into the biological and clinical characteristics of malignant tumors...
2016: International Journal of Medical Sciences
https://www.readbyqxmd.com/read/27994494/association-of-physical-performance-and-biochemical-profile-of-mice-with-intrinsic-endurance-swimming
#13
Wen-Ching Huang, Yi-Ju Hsu, Li Wei, Ying-Ju Chen, Chi-Chang Huang
We aimed to investigate the potential mediators and relationship affecting congenital exercise performance in an animal model with physical activity challenge from physiological and biochemical perspectives. A total of 75 male ICR mice (5 weeks old) were adapted for 1 week, then mice performed a non-loading and exhaustive swimming test and were assigned to 3 groups by exhaustive swimming time: low exercise capacity (LEC) (<3 hr), medium exercise capacity (MEC) (3-5 hr), and high exercise capacity (HEC) (>5 hr)...
2016: International Journal of Medical Sciences
https://www.readbyqxmd.com/read/27877080/established-population-of-blacklegged-ticks-with-high-infection-prevalence-for-the-lyme-disease-bacterium-borrelia-burgdorferi-sensu-lato-on-corkscrew-island-kenora-district-ontario
#14
John D Scott, Janet E Foley, Kerry L Clark, John F Anderson, Lance A Durden, Jodi M Manord, Morgan L Smith
We document an established population of blacklegged ticks, Ixodes scapularis, on Corkscrew Island, Kenora District, Ontario, Canada. Primers of the outer surface protein A (OspA) gene, the flagellin (fla) gene, and the flagellin B (flaB) gene were used in the PCR assays to detect Borrelia burgdorferi sensu lato (s.l.), the Lyme disease bacterium. In all, 60 (73%) of 82 adult I. scapularis, were infected with B. burgdorferi s.l. As well, 6 (43%) of 14 unfed I. scapularis nymphs were positive for B. burgdorferi s...
2016: International Journal of Medical Sciences
https://www.readbyqxmd.com/read/27877079/amplification-and-overexpression-of-cttn-and-ccnd1-at-chromosome-11q13-in-esophagus-squamous-cell-carcinoma-escc-of-north-eastern-chinese-population
#15
Xiaoxia Hu, Ji Wook Moon, Shibo Li, Weihong Xu, Xianfu Wang, Yuanyuan Liu, Ji-Yun Lee
Esophageal squamous cell carcinoma (ESCC) is a genetically complex tumor type and is a major cause of cancer-related mortality. The combination of genetics, diet, behavior, and environment plays an important role in the carcinogenesis of ESCC. To characterize the genomic aberrations of this disease, we investigated the genomic imbalances in 19 primary ESCC cases using high-resolution array comparative genomic hybridization (CGH). All cases showed either loss or gain of whole chromosomes or segments of chromosome(s) with variable genomic sizes...
2016: International Journal of Medical Sciences
https://www.readbyqxmd.com/read/27877078/activation-of-the-cxcl16-cxcr6-pathway-by-inflammation-contributes-to-atherosclerosis-in-patients-with-end-stage-renal-disease
#16
Ze Bo Hu, Yan Chen, Yu Xiang Gong, Min Gao, Yang Zhang, Gui Hua Wang, Ri Ning Tang, Hong Liu, Bi Cheng Liu, Kun Ling Ma
Background: Chronic inflammation plays a critical role in the progression of atherosclerosis (AS). This study aimed to determine the effects of the CXC chemokine ligand 16 (CXCL16)/CXC chemokine receptor 6 (CXCR6) pathway on cholesterol accumulation in the radial arteries of end-stage renal disease (ESRD) patients with concomitant microinflammation and to further investigate the potential effects of the purinergic receptor P2X ligand-gated ion channel 7 (P2X7R). Methods: Forty-three ESRD patients were divided into the control group (n=17) and the inflamed group (n=26) based on plasma C-reactive protein (CRP) levels...
2016: International Journal of Medical Sciences
https://www.readbyqxmd.com/read/27877077/amelioration-of-estrogen-deficiency-induced-obesity-by-collagen-hydrolysate
#17
Tsay-I Chiang, I-Chang Chang, Hsueh-Hui Lee, Kuang Hui Hsieh, Yung-Wei Chiu, Te-Jen Lai, Jer-Yuh Liu, Li-Sung Hsu, Shao-Hsuan Kao
Objectives: Menopausal transition with declining estrogen levels significantly affects the physiological properties of women and consequently contributes to a series of medical conditions, including obesity. Obesity is a crucial risk factor associated with cardiovascular diseases, diabetes mellitus, and breast cancer. Increasing dietary protein content improves satiety and energy expenditure. Thus, we hypothesize that supplementing with collagen, a common dietary protein, may alleviate menopause-induced obesity...
2016: International Journal of Medical Sciences
https://www.readbyqxmd.com/read/27877076/cardiomyogenic-differentiation-of-human-dental-follicle-derived-stem-cells-by-suberoylanilide-hydroxamic-acid-and-their-in-vivo-homing-property
#18
Iel-Yong Sung, Han-Na Son, Imran Ullah, Dinesh Bharti, Ju-Mi Park, Yeong-Cheol Cho, June-Ho Byun, Young-Hoon Kang, Su-Jin Sung, Jong-Woo Kim, Gyu-Jin Rho, Bong-Wook Park
The purpose of the present study was to investigate the in vitro cardiomyogenic differentiation potential of human dental follicle-derived stem cells (DFCs) under the influence of suberoylanilide hydroxamic acid (SAHA), a member of the histone deacetylase inhibitor family, and analyze the in vivo homing capacity of induced cardiomyocytes (iCMs) when transplanted systemically. DFCs from extracted wisdom teeth showed mesenchymal stem cell (MSC) characteristics such as plate adherent growing, expression of MSC markers (CD44, CD90, and CD105), and mesenchymal lineage-specific differentiation potential...
2016: International Journal of Medical Sciences
https://www.readbyqxmd.com/read/27877075/the-limbal-epithelial-progenitors-in-the-limbal-niche-environment
#19
REVIEW
Yuan Zhang, Hong Sun, Yongsong Liu, Shuangling Chen, Subo Cai, Yingting Zhu, Ping Guo
Limbal epithelial progenitors are stem cells located in limbal palisades of vogt. In this review, we present the audience with recent evidence that limbal epithelial progenitors may be a powerful stem cell resource for the cure of human corneal stem cell deficiency. Further understanding of their mechanism may shed lights to the future successful application of stem cell therapy not only to the eye tissue, but also to the other tissues in the human body.
2016: International Journal of Medical Sciences
https://www.readbyqxmd.com/read/27877074/association-between-benzodiazepine-use-and-dementia-data-mining-of-different-medical-databases
#20
Mitsutaka Takada, Mai Fujimoto, Kouichi Hosomi
Purpose: Some studies have suggested that the use of benzodiazepines in the elderly is associated with an increased risk of dementia. However, this association might be due to confounding by indication and reverse causation. To examine the association between benzodiazepine anxiolytic drug use and the risk of dementia, we conducted data mining of a spontaneous reporting database and a large organized database of prescriptions. Methods: Data from the US Food and Drug Administration Adverse Event Reporting System (FAERS) from the first quarter of 2004 through the end of 2013 and data from the Canada Vigilance Adverse Reaction Online Database from the first quarter of 1965 through the end of 2013 were used for the analyses...
2016: International Journal of Medical Sciences
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