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Quarterly Journal of Nuclear Medicine and Molecular Imaging

Eduardo Delgado-Oliver, Sergi Vidal-Sicart, Daniel Martínez, Mattia Squarcia, Mireia Mora, Felizia A Hanzu, Irene Halperin, David Fuster, Constantino Fondevila, Óscar Vidal-Perez
BACKGROUND: The optimal surgical management of papillary thyroid cancer (PTC) for T1-T2 tumors without pre or intrasurgical evidence of lymph node metastasis (cN0) remains controversial, since approximately 40% of patients have lymph node involvement (pN1) which becomes evident when a prophylactic lymphadenectomy (PL) is performed. The aim of this study was to investigate the feasibility of sentinel lymph node (SLN) identification with SPECT/CT lymphoscintigraphy imaging along with intraoperatory image techniques in early stages of PTC undergoing PL of central neck compartment (CNC)...
July 9, 2018: Quarterly Journal of Nuclear Medicine and Molecular Imaging
Martin Barth, Andreas Dunzinger, Irina Wimmer, Johanna Winkler, Hans Rittmannsberger, Michael Nader, Robert Pichler
BACKGROUND: More than 50% of patients with major depressive episode (MDE) fail to respond to initial treatment with first line pharmacological therapy. Altered receptor and serotonin transporter function are considered to be associated with mental disorders. Our investigation aimed on the density of the HT1A receptor in mesiotemporal cortex (MTC) and raphe measured by F18-Mefway in patients with MDD. METHODS: Patients with untreated clinically suspected major depressive episode were recruited from June 2012 to May 2014...
June 14, 2018: Quarterly Journal of Nuclear Medicine and Molecular Imaging
Gagandeep Choudhary, Karl-Josef Langen, Norbert Galldiks, Jonathan Mcconathy
High-grade gliomas (HGGs) are the most common primary malignant tumors of the brain, with glioblastoma (GBM) constituting over 50% of all the gliomas in adults. The disease carries very high mortality, and even with optimal treatment, the median survival is 2-5 years for anaplastic tumors and 1-2 years for GBMs. Neuroimaging is critical to managing patients with HGG for diagnosis, treatment planning, response assessment, and detecting recurrent disease. Magnetic resonance imaging (MRI) is the cornerstone of imaging in neuro-oncology, but molecular imaging with positron emission tomography (PET) can overcome some of the inherent limitations of MRI...
June 4, 2018: Quarterly Journal of Nuclear Medicine and Molecular Imaging
Philipp Lohmann, Martin Kocher, Jan Steger, Norbert Galldiks
Radiomics is a technique that uses high-throughput computing to extract quantitative features from tomographic medical images such as MRI and PET that usually are beyond visual perception. Importantly, the radiomics approach can be performed using neuroimages that have already been acquired during the routine follow-up of the patients allowing an additional data evaluation at low cost. In Neuro-Oncology, these features can potentially be used for differential diagnosis of newly diagnosed cerebral lesions suggestive for brain tumors or for the prediction of response to a neurooncological treatment option...
June 4, 2018: Quarterly Journal of Nuclear Medicine and Molecular Imaging
Olga Hamming-Vrieze, Arash Navran, Abrahim Al-Mamgani, Wouter V Vogel
INTRODUCTION: In recent years, the possibility of adapting radiotherapy to changes in biological tissue parameters has emerged. It is hypothesized that early identification of radio-resistant parts of the tumor during treatment provides the possibility to adjust the radiotherapy plan to improve outcome. The aim of this systematic literature review was to evaluate the current state of the art of biological PET-guided adaptive radiotherapy, focusing on dose escalation to radio-resistant tumor...
June 4, 2018: Quarterly Journal of Nuclear Medicine and Molecular Imaging
Willem Grootjans, Lioe-Fee de Geus-Oei, Johan Bussink
With a worldwide annual incidence of 1.8 million cases, lung cancer is the most diagnosed form of cancer in men and the second most diagnosed form of cancer in women. Histologically, 80-85% of all lung cancers can be categorized as non-small cell lung cancer (NSCLC). For patients with locally advanced NSCLC, standard of care is fractionated radiotherapy combined with chemotherapy. With the aim of improving clinical outcome of patients with locally advanced NSCLC, combined and intensified treatment approaches are increasingly being used...
June 4, 2018: Quarterly Journal of Nuclear Medicine and Molecular Imaging
Judit A Adam, Hester Arkies, Karel Hinnen, Lukas J Stalpers, Jan H van Waesberghe, Jaap Stoker, Rob van Os, Janna J Laan, Constantijne H Mom, Berthe L van Eck-Smit
BACKGROUND: In patients with advanced stage cancer of the uterine cervix who undergo irradiation with curative intent, there is the necessity to treat all suspicious nodes on imaging. Our hypothesis was that adding PET/CT to the imaging workup would alter the EBRT treatment plan, either resulting in an extended EBRT field to the para-aortal region or an additional boost to suspicious nodes. Since extended field radiotherapy or additional boost can cause toxicity, our secondary aim was to assess the incidence of severe late bowel toxicity in patients treated with extended para-aortal EBRT-field compared to elective pelvic EBRT...
June 4, 2018: Quarterly Journal of Nuclear Medicine and Molecular Imaging
Philippe Bulens, Melissa Thomas, Christophe M Deroose, Karin Haustermans
Radiotherapy is the standard of care in the multimodality treatment of a variety of gastrointestinal (GI) tumours, such as oesophageal cancer, gastric cancer, rectal cancer and anal cancer. Additionally, radiotherapy has served as an alternative for surgery in patients with liver cancer, cancer of the biliary tract and pancreatic cancer. Positron-emission tomography (PET), generally in combination with computed tomography (CT), has an established role in the diagnosis, response assessment and (re-)staging of several GI tumours...
June 4, 2018: Quarterly Journal of Nuclear Medicine and Molecular Imaging
Bettina Beuthien-Baumann, Stefan A Koerber
The integration of data from positron-emission-tomography, combined with computed tomography as PET/CT or combined with magnet resonance imaging as PET/MRI, into radiation treatment planning of prostate cancer is gaining higher impact with the development of more sensitive and specific radioligands. The classic PET-tracer for prostate cancer imaging are [11C]choline and [11C]acetate, which are currently outperformed by ligands binding to the prostate-specific- membrane-antigen (PSMA). [68Ga]PSMA-11, which is the most frequently applied tracer, has shown to detect lymph node metastases, local recurrences, distant metastases and intraprostatic foci with high sensitivity, even at relatively low PSA levels...
June 4, 2018: Quarterly Journal of Nuclear Medicine and Molecular Imaging
Norbert Galldiks
No abstract text is available yet for this article.
May 16, 2018: Quarterly Journal of Nuclear Medicine and Molecular Imaging
Lukas J Volz, Martin Kocher, Philipp Lohmann, Nadim J Shah, Gereon R Fink, Norbert Galldiks
Functional magnetic resonance imaging (fMRI) allows the non-invasive assessment of human brain activity in-vivo. In glioma patients, fMRI is frequently used to determine the individual functional anatomy of the motor and language network in a pre-surgical setting to optimize surgical procedures and prevent extensive damage to functionally eloquent areas. Novel developments based on resting- state fMRI may help to improve pre-surgical planning for patients which are unable to perform structured tasks and might extend pre-surgical mapping to include additional functional networks...
May 14, 2018: Quarterly Journal of Nuclear Medicine and Molecular Imaging
Bert-Ram Sah, Christian A Leissing, Gaspar Delso, Edwin E Ter Voert, Stefan Krieg, Sebastian Leibl, Paul M Schneider, Cäcilia S Reiner, Martin W Hüllner, Patrick Veit-Haibach
BACKGROUND: Positron emission tomography (PET) / computed tomography (CT) is among the most frequently used imaging modalities for initial staging of gastro-oesophageal (GE) cancer, whereas CT-perfusion (CTP) provides different multiparametric information. This proof of concept study compares CTP- and PET-parameters in patients with GE cancer to evaluate correlations and a possible prognostic value of a combined PET/CTP imaging procedure. METHODS: A total of 31 patients with F-18-FDG-PET/CT and CTP studies were prospectively analysed...
May 10, 2018: Quarterly Journal of Nuclear Medicine and Molecular Imaging
Cigdem Soydal, Yuksel Urun, Evren Suer, Demet Nak, Elgin Ozkan, Ozlem N Kucuk
BACKGROUND: The aim of this study is to evaluate predictive factors of 68Gallium (68Ga) Prostate-Specific Membrane Antigen (PSMA) Positron Emission Tomography (PET)/Computed Tomography (CT) positivity. METHODS: Relationships between serum Prostate Specific Antigen (PSA), Lactate dehydrogenase (LDH) and alkaline phosphatase (ALP) levels, Gleason Score (GS) and positivity of 68Ga PSMA PET in patients who underwent 68Ga PSMA PET/CT for restaging for PCa were evaluated retrospectively...
May 10, 2018: Quarterly Journal of Nuclear Medicine and Molecular Imaging
Alessia Pellerino, Federica Franchino, Riccardo Soffietti, Roberta Rudà
High-grade gliomas (HGGs) are the most common primary tumors of the Central Nervous System, which include anaplastic gliomas (grade III) and glioblastomas (GBM, grade IV). Surgery is the mainstay of treatment in HGGs in order to achieve a histological and molecular characterization, as well as relieve neurological symptoms and improve seizure control. Combinations of some molecular factors, such as IDH 1-2 mutations, 1p/19q codeletion and MGMT methylation status, allow to classify different subtypes of gliomas and identify patients with different outcome...
April 26, 2018: Quarterly Journal of Nuclear Medicine and Molecular Imaging
Antoine Verger, Javier Arbizu, Ian Law
Positron emission tomography (PET) using radiolabelled amino acids was recently recommended by the Response Assessment in Neuro-Oncology (RANO) working group as an additional tool in the diagnostic assessment of brain tumours. The aim of this review is to summarise available literature data on the role of amino-acid PET imaging in high-grade gliomas (HGGs), with regard to diagnosis, treatment planning and follow-up of these tumours. Indeed, amino acid PET applications are multiple throughout the evolution of HGGs...
April 26, 2018: Quarterly Journal of Nuclear Medicine and Molecular Imaging
Bogdana Suchorska, Nathalie L Albert, Elena K Bauer, Jörg-Christian Tonn, Norbert Galldiks
INTRODUCTION: Since its introduction in 2016, the revision of the World Health Organization (WHO) classification of central nervous system tumours has already changed the diagnostic and therapeutic approach in glial tumors. Blurring the lines between entities formerly labelled as "high-grade" or "low-grade", molecular markers define distinct biological subtypes with different clinical course. This new classification raises the demand for non-invasive imaging methods focussing on depicting metabolic processes...
April 26, 2018: Quarterly Journal of Nuclear Medicine and Molecular Imaging
Whitney B Pope, Garth Brandal
Magnetic resonance imaging is integral to the care of patients with high grade gliomas. Anatomic detail can be acquired with conventional structural imaging, but newer approaches also add capabilities to interrogate image-derived physiologic and molecular characteristics of central nervous system neoplasms. These advanced imaging techniques are increasingly employed to generate biomarkers that better reflect tumor burden and therapy response. The following is an overview of current strategies based on advanced magnetic resonance imaging that are used in the assessment of high grade glioma patients with an emphasis on how novel imaging biomarkers can potentially advance patient care...
April 26, 2018: Quarterly Journal of Nuclear Medicine and Molecular Imaging
Mahdi Haghighatafshar, Reza Nowshad, Zahra Etemadi, Tahereh Ghaedian
BACKGROUND: Although, different methods have been suggested on reducing salivary gland radiation after radioiodine administration, an effective preventive or therapeutic measure is still debateful. To the best of our knowledge this is the second study that aimed to evaluate the effect of chewing-gum as a sialagogue on the radioiodine content of salivary gland, and radioiodine- induced symptoms of salivary gland dysfunction. METHODS: Twenty two patients who were referred to radioiodine therapy were randomized into chewing-gum (group A) and control (group B) groups...
April 26, 2018: Quarterly Journal of Nuclear Medicine and Molecular Imaging
Flavio Nobili, Annachiara Cagnin, Maria L Calcagni, Andrea Chincarini, Ugo P Guerra, Silvia Morbelli, Alessandro Padovani, Barbara Paghera, Sabina Pappatà, Lucilla Parnetti, Stelvio Sestini, Orazio Schillaci
In May, 2017 some representatives of the Italian nuclear medicine and neurological communities spontaneously met to discuss the issues emerged during the first two years of routine application of amyloid PET with fluorinated radiopharmaceuticals in the real world. The limitations of a binary classification of scans, the possibility to obtain early images as a surrogate marker of regional cerebral bloos flow, the need for (semi-)quantification and, thus, the opportunity of ranking brain amyloidosis, the correlation with Aβ42 levels in the cerebrospinal fluid, the occurrence and biological meaning of uncertain/boderline scans, the issue of incidental amyloidosis, the technical pittfalls leading to false negative/positive results, the position of the tool in the diagnostic flow- chart in the national reality, are the main topics that have been discussed...
April 24, 2018: Quarterly Journal of Nuclear Medicine and Molecular Imaging
Barbara Salvatore, Rosa Fonti, Amalia De Renzo, Sara Pellegrino, Ida L Ferrara, Ciro G Mainolfi, Luana Marano, Carmine Selleri, Fabrizio Pane, Silvana Del Vecchio, Leonardo Pace
BACKGROUND: We evaluated the role of [18F]FDG PET/CT in tumor response assessment and prognosis of Primary Extranodal Lymphoma (PEL) patients. METHODS: We examined retrospectively, 56 PEL patients: 31 with aggressive diffuse large B cell lymphoma (DLBCL) and 25 with indolent lymphoma (20 mucosa-associated lymphoid tissue lymphoma-MALT and 5 follicular lymphoma). All patients had undergone [18F]FDG PET/CT at diagnosis (PET-I) and 50 of them also after therapy (PET-II)...
April 24, 2018: Quarterly Journal of Nuclear Medicine and Molecular Imaging
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