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Quarterly Journal of Nuclear Medicine and Molecular Imaging

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https://www.readbyqxmd.com/read/30221907/comparison-of-post-therapeutic-sequential-131i-whole-body-scans-in-the-detection-of-metastatic-thyroid-cancer
#1
Lin Qui, Hui Tan, Hongyan Yin, Jun Zhou, Dengfeng Cheng, Hongcheng Shi
BACKGROUND: The aim was to compare the detect ability of 3 sequential 131I whole-body scans (tri-WBS) on the second, third, and fourth day after 131I therapy for metastatic thyroid cancer. METHODS: Differentiated thyroid cancer patients who received oral high-dose 131I therapy underwent routinely tri-WBS on the second, third, and fourth day after total or near-total thyroidectomy in our hospital. We enrolled 137 patients with 261 tri-WBSs in this study between January 2015 and November 2017...
September 13, 2018: Quarterly Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/30221906/evaluation-of-physiologic-and-abnormal-glucose-uptake-in-palatine-tonsils-differential-diagnostics-with-sequential-dual-time-point-2-deoxy-2-18f-fluoro-d-glucose-positron-emission-tomography-computed-tomography-examinations
#2
Agata K Pietrzak, Joanna Kazmierska, Andrzej Marszalek, Witold Cholewinski
BACKGROUND: The aim of this article was to evaluate the usefulness of sequential dual- time-point 2-deoxy-2-[18F]fluoro-D-glucose positron emission tomography/computed tomography (DTP [18F]FDG PET/CT) in distinguishing physiologic, inflammatory and malignant palatine tonsils as difficult to differentiate in the oncological practice. METHODS: A total of 90 patients before the treatment underwent sequential DTP [18F]FDG PET/CT examinations. We analyzed 104 structures in 90 patients: 31 physiologic tonsils, 28 histopathologically confirmed inflammatory tonsils of non-specified origin, 31 histopathologically confirmed palatine tonsils cancer and 14 non-malignant contralateral tonsils in patients with histopathologically confirmed unilateral palatine tonsil malignancy...
September 13, 2018: Quarterly Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/30221905/predictive-factors-determining-incomplete-response-to-radioiodine-therapy-in-patients-with-differentiated-thyroid-cancer
#3
Ewelina Szczepanek-Parulska, Magdalena Wojewoda-Korbelak, Martyna Borowczyk, Malgorzata Kaluzna, Barbara Brominska, Katarzyna Ziemnicka, Rafal Czepczynski, Maciej Baczyk, Marek Ruchala
BACKGROUND: Although differentiated thyroid cancer (DTC) has relatively favorable course, factors predicting the course of the disease are intensively searched. The aim of the study was to identify the clinical factors determining incomplete response to radioiodine therapy in patients with differentiated thyroid cancer. METHODS: We retrospectively analyzed 385 consecutive patients with DTC treated and followed-up at a single tertiary reference center. We investigated clinical factors detectable during first hospitalization 3-6 months following total thyroidectomy due to DTC, which may serve as prognostic factors determining response to DTC therapy in a long-term follow-up...
September 13, 2018: Quarterly Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/30160089/correlation-of-18f-fdg-uptake-and-thyroid-cancer-stem-cells
#4
Ya-Ju Hsieh, Tzu-Ying Lu, Chien-Chih Ke, Yaoh-Shiang Lin, Hsiao-Ting Tai, Shiuh-Inn Liu, Tsung-Jung Liang, Hsing-Hao Su, Ren-Shyan Liu, Nan-Jing Peng
BACKGROUND: 2-deoxy-2-[18F]fluoro-D-glucose positron emission tomography (18F-FDG PET) has the potential to detect various types of cancers, including thyroid cancer (TC), at a potentially curable stage. Increased uptake of 18F-FDG was observed in anaplastic and poorly differentiated thyroid cancer cells, and PET-positive tumors are more likely to be resistant to 131I treatment. As cancer stem cells (CSCs) possess a dedifferentiated phenotype and are resistant to many anticancer therapies, we hypothesized that the expression of CSC-related markers is correlated with the ability of tumor cells in TC to uptake FDG...
August 28, 2018: Quarterly Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/29999291/applicability-of-sentinel-lymph-node-biopsy-in-papillary-thyroid-cancer
#5
Eduardo Delgado-Oliver, Sergi Vidal-Sicart, Daniel Martínez, Mattia Squarcia, Mireia Mora, Felizia A Hanzu, Irene Halperin, David Fuster, Constantino Fondevila, Óscar Vidal-Perez
BACKGROUND: The optimal surgical management of papillary thyroid cancer (PTC) for T1-T2 tumors without pre or intrasurgical evidence of lymph node metastasis (cN0) remains controversial, since approximately 40% of patients have lymph node involvement (pN1) which becomes evident when a prophylactic lymphadenectomy (PL) is performed. The aim of this study was to investigate the feasibility of sentinel lymph node (SLN) identification with SPECT/CT lymphoscintigraphy imaging along with intraoperatory image techniques in early stages of PTC undergoing PL of central neck compartment (CNC)...
July 9, 2018: Quarterly Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/29869489/investigational-pet-tracers-for-high-grade-gliomas
#6
Gagandeep Choudhary, Karl-Josef Langen, Norbert Galldiks, Jonathan McConathy
High-grade gliomas (HGGs) are the most common primary malignant tumors of the brain, with glioblastoma (GBM) constituting over 50% of all the gliomas in adults. The disease carries very high mortality, and even with optimal treatment, the median survival is 2-5 years for anaplastic tumors and 1-2 years for GBMs. Neuroimaging is critical to managing patients with HGG for diagnosis, treatment planning, response assessment, and detecting recurrent disease. Magnetic resonance imaging (MRI) is the cornerstone of imaging in neuro-oncology, but molecular imaging with positron emission tomography (PET) can overcome some of the inherent limitations of MRI...
September 2018: Quarterly Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/29869488/radiomics-derived-from-amino-acid-pet-and-conventional-mri-in-patients-with-high-grade-gliomas
#7
Philipp Lohmann, Martin Kocher, Jan Steger, Norbert Galldiks
Radiomics is a technique that uses high-throughput computing to extract quantitative features from tomographic medical images such as MRI and PET that usually are beyond visual perception. Importantly, the radiomics approach can be performed using neuroimages that have already been acquired during the routine follow-up of the patients allowing an additional data evaluation at low cost. In Neuro-Oncology, these features can potentially be used for differential diagnosis of newly diagnosed cerebral lesions suggestive for brain tumors or for the prediction of response to a neurooncological treatment option...
September 2018: Quarterly Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/29781593/neuroimaging-in-patients-with-high-grade-gliomas
#8
Norbert Galldiks
No abstract text is available yet for this article.
September 2018: Quarterly Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/29761998/functional-magnetic-resonance-imaging-in-glioma-patients-from-clinical-applications-to-future-perspectives
#9
Lukas J Volz, Martin Kocher, Philipp Lohmann, Nadim J Shah, Gereon R Fink, Norbert Galldiks
Functional magnetic resonance imaging (fMRI) allows the non-invasive assessment of human brain activity in vivo. In glioma patients, fMRI is frequently used to determine the individual functional anatomy of the motor and language network in a presurgical setting to optimize surgical procedures and prevent extensive damage to functionally eloquent areas. Novel developments based on resting-state fMRI may help to improve presurgical planning for patients which are unable to perform structured tasks and might extend presurgical mapping to include additional functional networks...
September 2018: Quarterly Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/29696949/overview-on-current-treatment-standards-in-high-grade-gliomas
#10
Alessia Pellerino, Federica Franchino, Riccardo Soffietti, Roberta Rudà
High-grade gliomas (HGGs) are the most common primary tumors of the central nervous system, which include anaplastic gliomas (grade III) and glioblastomas (GBM, grade IV). Surgery is the mainstay of treatment in HGGs in order to achieve a histological and molecular characterization, as well as relieve neurological symptoms and improve seizure control. Combinations of some molecular factors, such as IDH 1-2 mutations, 1p/19q codeletion and MGMT methylation status, allow to classify different subtypes of gliomas and identify patients with different outcome...
September 2018: Quarterly Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/29696948/role-of-amino-acid-pet-in-high-grade-gliomas-limitations-and-perspectives
#11
Antoine Verger, Javier Arbizu, Ian Law
Positron emission tomography (PET) using radiolabeled amino-acids was recently recommended by the Response Assessment in Neuro-Oncology (RANO) working group as an additional tool in the diagnostic assessment of brain tumors. The aim of this review is to summarize available literature data on the role of amino-acid PET imaging in high-grade gliomas (HGGs), with regard to diagnosis, treatment planning and follow-up of these tumors. Indeed, amino-acid PET applications are multiple throughout the evolution of HGGs...
September 2018: Quarterly Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/29696947/the-role-of-amino-acid-pet-in-the-light-of-the-new-who-classification-2016-for-brain-tumors
#12
Bogdana Suchorska, Nathalie L Albert, Elena K Bauer, Jörg-Christian Tonn, Norbert Galldiks
Since its introduction in 2016, the revision of the World Health Organization (WHO) classification of central nervous system tumors has already changed the diagnostic and therapeutic approach in glial tumors. Blurring the lines between entities formerly labelled as "high-grade" or "low-grade", molecular markers define distinct biological subtypes with different clinical course. This new classification raises the demand for non-invasive imaging methods focusing on depicting metabolic processes...
September 2018: Quarterly Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/29696946/conventional-and-advanced-magnetic-resonance-imaging-in-patients-with-high-grade-glioma
#13
Whitney B Pope, Garth Brandal
Magnetic resonance imaging is integral to the care of patients with high-grade gliomas. Anatomic detail can be acquired with conventional structural imaging, but newer approaches also add capabilities to interrogate image-derived physiologic and molecular characteristics of central nervous system neoplasms. These advanced imaging techniques are increasingly employed to generate biomarkers that better reflect tumor burden and therapy response. The following is an overview of current strategies based on advanced magnetic resonance imaging that are used in the assessment of high-grade glioma patients with an emphasis on how novel imaging biomarkers can potentially advance patient care...
September 2018: Quarterly Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/27007665/reversible-myocardial-perfusion-defects-in-patients-not-suffering-from-obstructive-epicardial-coronary-artery-disease-as-assessed-by-coronary-angiography
#14
Christophe van de Wiele, Adriana Rimbu, Tarik Belhocine, Bart de Spiegeleer, Mike Sathekge, Alex Maes
In approximately 10-30% of patients presenting with angina complaints, normal or non-obstructive coronary arteries are found on angiography. In this review paper, available literature on the underlying pathophysiological substrate explaining these discrepancies is reviewed. Both histological studies as well as studies using intravascular ultrasound e.g. the PROSPECT trial, show that epicardial coronary vessel significant lumen stenosis may be delayed until a plaque occupies 40% of the internal elastic lamina area...
September 2018: Quarterly Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/26883516/half-time-bone-scintigraphy-in-prostate-and-breast-cancer-patients
#15
Willem Grootjans, Sara J Serém, Monique I Gomes, Linda Heijmen, Ben F Bulten, Eddy P Mijnheere, Rick Hermsen, Wim J van den Broek
BACKGROUND: Developments in image reconstruction techniques for planar imaging, also known as enhanced planar processing (EPP), enable the possibility to reconstruct planar scintigraphic images with low count statistics, providing the opportunity to reduce image acquisition time. In this study, the performance of EPP for oncologic half-time bone scintigraphy images was evaluated. METHODS: The EPP software was evaluated for different imaging conditions using standardized phantom experiments...
September 2018: Quarterly Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/26788806/clinical-value-of-quantitative-measurements-derived-from-gated-spect-motion-and-thickening-volumes-and-related-lvef
#16
Walter Noordzij, Riemer H Slart
Radionuclide myocardial perfusion imaging using ECG-gated acquisition with single photon emission computed tomography (gated SPECT) is the current state of the art imaging modality for symptomatic patients with known or at least indeterminate likelihood of coronary artery disease. Gated SPECT provides a wide variety of additional information about left ventricular (LV) function measurements, for example LV volumes, ejection fraction (LVEF) and regional wall motion abnormalities. This contributes to a higher diagnostic accuracy, additional prognostic information and predicting benefit from revascularization in these patients...
September 2018: Quarterly Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/26554525/evaluation-of-predictor-variables-of-diagnostic-18f-fdg-pet-ct-in-fever-of-unknown-origin
#17
Kursat Okuyucu, Engin Alagoz, Seref Demirbas, Semra Ince, Ahmet Karakas, Ozgur Karacalioglu, Bengul Gunalp, Nuri Arslan
BACKGROUND: Fever of unknown origin (FUO) is defined as an illness having fever which lasts at least 3 weeks of duration and is higher than 38.3 ºC on several measurements. The causes are infections, malignancies, noninfectious inflammatory diseases and miscellaneous. If [18F]FDG-PET/CT helps the final diagnosis, it is called contributory. The aim of the study is to evaluate the predictor variables effecting a contributory PET/CT for the diagnosis. METHODS: This is a retrospective cohort study conducted between June 2006 and May 2015 including 76 patients...
September 2018: Quarterly Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/29916219/serotonin-1a-receptor-density-measured-by-f18-mefway-pet-ct-in-mesiotemporal-cortex-and-raphe-does-not-discriminate-therapeutic-response-in-patients-with-major-depressive-episode
#18
Martin Barth, Andreas Dunzinger, Irina Wimmer, Johanna Winkler, Hans Rittmannsberger, Michael Nader, Robert Pichler
BACKGROUND: More than 50% of patients with major depressive episode (MDE) fail to respond to initial treatment with first line pharmacological therapy. Altered receptor and serotonin transporter function are considered to be associated with mental disorders. Our investigation aimed on the density of the HT1A receptor in mesiotemporal cortex (MTC) and raphe measured by F18-Mefway in patients with MDD. METHODS: Patients with untreated clinically suspected major depressive episode were recruited from June 2012 to May 2014...
June 14, 2018: Quarterly Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/29869487/biological-pet-guided-adaptive-radiotherapy-for-dose-escalation-in-head-and-neck-cancer-a-systematic-review
#19
Olga Hamming-Vrieze, Arash Navran, Abrahim Al-Mamgani, Wouter V Vogel
INTRODUCTION: In recent years, the possibility of adapting radiotherapy to changes in biological tissue parameters has emerged. It is hypothesized that early identification of radio-resistant parts of the tumor during treatment provides the possibility to adjust the radiotherapy plan to improve outcome. The aim of this systematic literature review was to evaluate the current state of the art of biological PET-guided adaptive radiotherapy, focusing on dose escalation to radio-resistant tumor...
June 4, 2018: Quarterly Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/29869486/image-guided-adaptive-radiotherapy-in-patients-with-locally-advanced-nsclc-the-art-of-pet
#20
Willem Grootjans, Lioe-Fee de Geus-Oei, Johan Bussink
With a worldwide annual incidence of 1.8 million cases, lung cancer is the most diagnosed form of cancer in men and the second most diagnosed form of cancer in women. Histologically, 80-85% of all lung cancers can be categorized as non-small cell lung cancer (NSCLC). For patients with locally advanced NSCLC, standard of care is fractionated radiotherapy combined with chemotherapy. With the aim of improving clinical outcome of patients with locally advanced NSCLC, combined and intensified treatment approaches are increasingly being used...
June 4, 2018: Quarterly Journal of Nuclear Medicine and Molecular Imaging
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