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Quarterly Journal of Nuclear Medicine and Molecular Imaging

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https://www.readbyqxmd.com/read/29781593/neuroimaging-in-patients-with-high-grade-gliomas
#1
Norbert Galldiks
No abstract text is available yet for this article.
May 16, 2018: Quarterly Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/29761998/functional-magnetic-resonance-imaging-in-glioma-patients-from-clinical-applications-to-future-perspectives
#2
Lukas J Volz, Martin Kocher, Philipp Lohmann, Nadim J Shah, Gereon R Fink, Norbert Galldiks
Functional magnetic resonance imaging (fMRI) allows the non-invasive assessment of human brain activity in-vivo. In glioma patients, fMRI is frequently used to determine the individual functional anatomy of the motor and language network in a pre-surgical setting to optimize surgical procedures and prevent extensive damage to functionally eloquent areas. Novel developments based on resting- state fMRI may help to improve pre-surgical planning for patients which are unable to perform structured tasks and might extend pre-surgical mapping to include additional functional networks...
May 14, 2018: Quarterly Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/29745630/evaluation-of-multifunctional-imaging-parameters-in-gastro-oesophageal-cancer-using-f-18-fdg-pet-ct-with-integrated-perfusion-ct
#3
Bert-Ram Sah, Christian A Leissing, Gaspar Delso, Edwin E Ter Voert, Stefan Krieg, Sebastian Leibl, Paul M Schneider, Cäcilia S Reiner, Martin W Hüllner, Patrick Veit-Haibach
BACKGROUND: Positron emission tomography (PET) / computed tomography (CT) is among the most frequently used imaging modalities for initial staging of gastro-oesophageal (GE) cancer, whereas CT-perfusion (CTP) provides different multiparametric information. This proof of concept study compares CTP- and PET-parameters in patients with GE cancer to evaluate correlations and a possible prognostic value of a combined PET/CTP imaging procedure. METHODS: A total of 31 patients with F-18-FDG-PET/CT and CTP studies were prospectively analysed...
May 10, 2018: Quarterly Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/29745629/psa-levels-as-a-predictor-of-68ga-psma-pet-ct-positivity-in-patients-with-prostate-cancer
#4
Cigdem Soydal, Yuksel Urun, Evren Suer, Demet Nak, Elgin Ozkan, Ozlem N Kucuk
BACKGROUND: The aim of this study is to evaluate predictive factors of 68Gallium (68Ga) Prostate-Specific Membrane Antigen (PSMA) Positron Emission Tomography (PET)/Computed Tomography (CT) positivity. METHODS: Relationships between serum Prostate Specific Antigen (PSA), Lactate dehydrogenase (LDH) and alkaline phosphatase (ALP) levels, Gleason Score (GS) and positivity of 68Ga PSMA PET in patients who underwent 68Ga PSMA PET/CT for restaging for PCa were evaluated retrospectively...
May 10, 2018: Quarterly Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/29696949/overview-on-current-treatment-standards-in-high-grade-gliomas
#5
Alessia Pellerino, Federica Franchino, Riccardo Soffietti, Roberta Rudà
High-grade gliomas (HGGs) are the most common primary tumors of the Central Nervous System, which include anaplastic gliomas (grade III) and glioblastomas (GBM, grade IV). Surgery is the mainstay of treatment in HGGs in order to achieve a histological and molecular characterization, as well as relieve neurological symptoms and improve seizure control. Combinations of some molecular factors, such as IDH 1-2 mutations, 1p/19q codeletion and MGMT methylation status, allow to classify different subtypes of gliomas and identify patients with different outcome...
April 26, 2018: Quarterly Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/29696948/role-of-amino-acid-pet-in-hggs-limitations-and-perspectives
#6
Antoine Verger, Javier Arbizu, Ian Law
Positron emission tomography (PET) using radiolabelled amino acids was recently recommended by the Response Assessment in Neuro-Oncology (RANO) working group as an additional tool in the diagnostic assessment of brain tumours. The aim of this review is to summarise available literature data on the role of amino-acid PET imaging in high-grade gliomas (HGGs), with regard to diagnosis, treatment planning and follow-up of these tumours. Indeed, amino acid PET applications are multiple throughout the evolution of HGGs...
April 26, 2018: Quarterly Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/29696947/the-role-of-amino-acid-pet-in-the-light-of-the-new-who-classification-2016-for-brain-tumors
#7
Bogdana Suchorska, Nathalie L Albert, Elena K Bauer, Jörg-Christian Tonn, Norbert Galldiks
INTRODUCTION: Since its introduction in 2016, the revision of the World Health Organization (WHO) classification of central nervous system tumours has already changed the diagnostic and therapeutic approach in glial tumors. Blurring the lines between entities formerly labelled as "high-grade" or "low-grade", molecular markers define distinct biological subtypes with different clinical course. This new classification raises the demand for non-invasive imaging methods focussing on depicting metabolic processes...
April 26, 2018: Quarterly Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/29696946/conventional-and-advanced-magnetic-resonance-imaging-in-patients-with-high-grade-glioma
#8
Whitney B Pope, Garth Brandal
Magnetic resonance imaging is integral to the care of patients with high grade gliomas. Anatomic detail can be acquired with conventional structural imaging, but newer approaches also add capabilities to interrogate image-derived physiologic and molecular characteristics of central nervous system neoplasms. These advanced imaging techniques are increasingly employed to generate biomarkers that better reflect tumor burden and therapy response. The following is an overview of current strategies based on advanced magnetic resonance imaging that are used in the assessment of high grade glioma patients with an emphasis on how novel imaging biomarkers can potentially advance patient care...
April 26, 2018: Quarterly Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/29696945/the-effect-of-chewing-gum-on-dose-rate-of-salivary-gland-in-differentiated-thyroid-carcinoma-patients-treated-with-radioiodine
#9
Mahdi Haghighatafshar, Reza Nowshad, Zahra Etemadi, Tahereh Ghaedian
BACKGROUND: Although, different methods have been suggested on reducing salivary gland radiation after radioiodine administration, an effective preventive or therapeutic measure is still debateful. To the best of our knowledge this is the second study that aimed to evaluate the effect of chewing-gum as a sialagogue on the radioiodine content of salivary gland, and radioiodine- induced symptoms of salivary gland dysfunction. METHODS: Twenty two patients who were referred to radioiodine therapy were randomized into chewing-gum (group A) and control (group B) groups...
April 26, 2018: Quarterly Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/29697220/emerging-topics-and-practical-aspects-for-an-appropriate-use-of-amyloid-pet-in-the-current-italian-context
#10
Flavio Nobili, Annachiara Cagnin, Maria L Calcagni, Andrea Chincarini, Ugo P Guerra, Silvia Morbelli, Alessandro Padovani, Barbara Paghera, Sabina Pappatà, Lucilla Parnetti, Stelvio Sestini, Orazio Schillaci
In May, 2017 some representatives of the Italian nuclear medicine and neurological communities spontaneously met to discuss the issues emerged during the first two years of routine application of amyloid PET with fluorinated radiopharmaceuticals in the real world. The limitations of a binary classification of scans, the possibility to obtain early images as a surrogate marker of regional cerebral bloos flow, the need for (semi-)quantification and, thus, the opportunity of ranking brain amyloidosis, the correlation with Aβ42 levels in the cerebrospinal fluid, the occurrence and biological meaning of uncertain/boderline scans, the issue of incidental amyloidosis, the technical pittfalls leading to false negative/positive results, the position of the tool in the diagnostic flow- chart in the national reality, are the main topics that have been discussed...
April 24, 2018: Quarterly Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/29697219/2-deoxy-2-18f-fluoro-d-glucose-positron-emission-tomography-computed-tomography-in-primary-extranodal-lymphomas-treatment-response-evaluation-and-prognosis
#11
Barbara Salvatore, Rosa Fonti, Amalia De Renzo, Sara Pellegrino, Ida L Ferrara, Ciro G Mainolfi, Luana Marano, Carmine Selleri, Fabrizio Pane, Silvana Del Vecchio, Leonardo Pace
BACKGROUND: We evaluated the role of [18F]FDG PET/CT in tumor response assessment and prognosis of Primary Extranodal Lymphoma (PEL) patients. METHODS: We examined retrospectively, 56 PEL patients: 31 with aggressive diffuse large B cell lymphoma (DLBCL) and 25 with indolent lymphoma (20 mucosa-associated lymphoid tissue lymphoma-MALT and 5 follicular lymphoma). All patients had undergone [18F]FDG PET/CT at diagnosis (PET-I) and 50 of them also after therapy (PET-II)...
April 24, 2018: Quarterly Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/29697218/total-fdg-lesion-number-on-pet-ct-predicts-survival-of-esophageal-carcinoma-patients-with-recurrence-following-curative-surgery
#12
Soo J Kim, Seung H Hyun, Seung H Moon, Young S Cho, Hyun K Yi, Young M Shim, Joon Y Choi, Byung-Tae Kim, Kyung-Han Lee
BACKGROUND: Total lesion number is a prognostic determinant in recurrent esophageal cancer, but this requires multiple tests. Here, we investigated the prognostic value of total FDG lesion number obtained from a single PET/CT study. METHODS: Subjects were 153 esophageal squamous cell carcinoma patients with loco-regional or distant recurrence following curative surgery. FDG PET/CT performed within 30 days was inspected for abnormal FDG uptake lesions using a SUVmax of 3...
April 24, 2018: Quarterly Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/29697217/blood-brain-barrier-transport-kinetics-of-nota-modified-proteins-the-somatropin-case
#13
Nathalie Bracke, Yorick Janssens, Evelien Wynendaele, Liesa Tack, Alex Maes, Christophe van de Wiele, Mike Sathekge, Bart De Spiegeleer
BACKGROUND: Chemical modifications such as PEG, polyamine and radio labeling on proteins can alter their pharmacokinetic behaviour and their blood-brain barrier (BBB) transport characteristics. NOTA, i.e. 1,4,7-triazacyclononane-1,4,7-triacetic acid, is a bifunctional chelating agent that has attracted the interest of the scientific community for its high complexation constant with metals like gallium. Until now, the comparative BBB transport characteristics of NOTA-modified proteins versus unmodified proteins are not yet described...
April 24, 2018: Quarterly Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/29521482/current-application-and-future-perspectives-of-psma-pet-imaging-in-prostate-cancer
#14
Francesco Ceci, Paolo Castellucci, Stefano Fanti
As precision medicine evolves, the contribution of molecular imaging to the management of prostate cancer (PCa) patients, especially for Positron Emission Tomography (PET) imaging, is gaining importance. Highly successful approaches to measure the expression of the prostate specific membrane antigen (PSMA) have been introduced recently. PSMA, the glutamate carboxypeptidase II (GCP-II), is a membrane bound metallo-peptidase that is overexpressed in 90-100% of PCa cells. Due to its selective over-expression, PSMA is a reliable tissue marker for prostate cancer and is considered an ideal target for tumor specific imaging and therapy...
March 8, 2018: Quarterly Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/29521481/radioiodine-ablation-in-thyroid-cancer-patients-renal-function-and-external-radiation-dose-rate-at-discharge-according-to-patient-preparation
#15
Yeon-Hee Han, Hwan-Jeong Jeong, Myung-Hee Sohn, Sun Y Lee, Seok T Lim
BACKGROUND: An elevated thyroid stimulating hormone (TSH) level is essential for the uptake of radioiodine into thyroid remnants and residual thyroid cancer in patients undergoing high-dose radioiodine therapy (HD-RIT). Recently, the use of recombinant human thyroid stimulating hormone (rh- TSH) has increased in preference over the conventional method of thyroid hormone withdrawal (THW). However, the clinical influences of the two methods, aside from the therapeutic effects, have not been widely evaluated...
March 8, 2018: Quarterly Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/29745214/imaging-in-the-evaluation-of-response-to-treatment-in-oncology
#16
Gianni Bisi
No abstract text is available yet for this article.
June 2018: Quarterly Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/29191001/hybrid-imaging-in-crohn-s-disease-from-spect-ct-to-pet-mr-and-new-image-interpretation-criteria
#17
Onofrio Catalano, Francesca Maccioni, Chiara Lauri, Sveva Auletta, Rudi Dierckx, Alberto Signore
Crohn's disease is a chronic relapsing disease characterized by mucosal inflammation, lymphocytes infiltration and fibrotic strictures. Usually, the assessment of location, extension, inflammatory activity and severity of intestinal lesions is complex and invasive with endoscopic methods or histological and biochemical investigations. Thus, the diagnosis remains a challenge for the management of patients. Nuclear medicine techniques, in particular hybrid and molecular imaging, might offer a valid option for the evaluation and determination of the prognosis of the disease...
March 2018: Quarterly Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/29191000/in-vivo-imaging-of-tumor-infiltrating-immune-cells-implications-for-cancer-immunotherapy
#18
Carolien Zeelen, Carmen Paus, Derk Draper, Sandra Heskamp, Alberto Signore, Filippo Galli, Cristoph M Griessinger, Erik H Aarntzen
Dynamic interactions between tumor cells and immune cells promote the initiation, progression, metastasis and therapy-resistance of cancer. With respect to immunotherapy, immune cell populations such as cytotoxic CD8+ T-cells, CD56+ NK cells and myeloid phagocytic cells play decisive roles. From an imaging perspective, the immune system displays unique challenges, which have implications for the design and performance of studies. The immune system comprises highly mobile cells that undergo distinct phases of development and activation...
March 2018: Quarterly Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/29190999/animal-models-for-the-study-of-inflammatory-bowel-diseases-a-meta-analysis-on-modalities-for-imaging-inflammatory-lesions
#19
Sveva Auletta, Rita Bonfiglio, Andreas Wunder, Michela Varani, Filippo Galli, Filippo Borri, Manuel Scimeca, Heiko G Niessen, Tanja Schönberger, Elena Bonanno
Inflammatory bowel diseases are lifelong disorders affecting the gastrointestinal tract characterized by intermittent disease flares and periods of remission with a progressive and destructive nature. Unfortunately, the exact etiology is still not completely known, therefore a causal therapy to cure the disease is not yet available. Current treatment options mainly encompass the use of non-specific anti-inflammatory agents and immunosuppressive drugs that cause significant side effects that often have a negative impact on patients' quality of life...
March 2018: Quarterly Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/29190998/radiological-and-nuclear-medicine-imaging-of-sarcoidosis
#20
Anna R Larici, Andor W Glaudemans, Annemilia Del Ciello, Riemer H Slart, Lucio Calandriello, Olivier Gheysens
Sarcoidosis is a multisystem chronic inflammatory disease of unknown etiology characterized by widespread growth of non-caseating granulomas. The diagnosis of sarcoidosis is based on clinical and imaging presentation, histologic confirmation and the absence of alternative diseases. Radiology and Nuclear Medicine play an essential role in the diagnostic work-up of patients with sarcoidosis to assess disease extent and activity. In addition, imaging modalities have shown their potential in managing these patients in terms of treatment response and prognostic assessment...
March 2018: Quarterly Journal of Nuclear Medicine and Molecular Imaging
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