journal
MENU ▼
Read by QxMD icon Read
search

Rejuvenation Research

journal
https://www.readbyqxmd.com/read/28281877/comprehensive-analysis-of-interaction-networks-of-telomerase-reverse-transcriptase-with-multiple-bioinformatic-approaches-deep-mining-the-potential-functions-of-telomere-and-telomerase
#1
Chunyu Hou, Fei Wang, Xuewen Liu, Guangming Chang, Feng Wang, Xin Geng
Telomerase reverse transcriptase (TERT) is the protein component of telomerase complex. Evidence has accumulated showing that the nontelomeric functions of TERT are independent of telomere elongation. However, the mechanisms governing the interaction between TERT and its target genes are not revealed clear. The biological functions of TERT are not fully elucidated and have thus far been underestimated. To further explore these functions, we investigated TERT interaction networks using multiple bioinformatic databases, including BioGRID, STRING, DAVID, GeneCards, GeneMANIA, PANTHER, miRWalk, mirTarBase, miRNet, miRDB, and TargetScan...
April 21, 2017: Rejuvenation Research
https://www.readbyqxmd.com/read/28398133/combined-effect-of-obesity-and-mobility-limitation-with-incident-of-type-2-diabetes-and-mortality-in-chinese-elderly
#2
Li Kang, Liye Jia, Peipei Han, Wen Zhang, Yixuan Ma, Liyuan Fu, Hairui Yu, Xiaoyu Chen, Lu Wang, Lin Hou, Xing Yu, Jianing Song, Ruiming He, Hui Li, Tingting Miao, Xiaolong Yang, Kaijun Niu, Liancheng Wang, Qi Guo
OBJECTIVE: This article aims to examine the effect of mobility limitation and obesity on the risk of new incidence of type 2 diabetes mellitus and mortality . METHODS: The design was a cohort study (n=1075) among adults aged 60 years and older. Obesity was defined as body mass index greater than or equal to 28 kg/m2. Mobility limitation was defined as participants scoring in the top 20% on the Timed Up and Go Test (TUGT) or in the slowest 20% for the 4-m walking test...
April 11, 2017: Rejuvenation Research
https://www.readbyqxmd.com/read/28384033/young-blood-plasma-administration-to-fight-alzheimer-s-disease
#3
Giorgio Aicardi
Despite decades of intensive research, no drugs can cure or even stabilize Alzheimer's disease (AD). Current pharmacological treatments only partially mask the symptoms while the disease progresses within the brain. Finding a preventive measure or a cure for people with AD is indeed a worldwide urgent priority. A recent interesting study by T. Wyss-Coray's research group provides the first evidence that exposure to young blood or plasma can reverse some AD-related molecular and behavioral alterations. Heterochronic parabiosis (shared blood circulation) of AD transgenic mice with young healthy mice did not reduce amyloidosis and microglial activation in AD mice, but reversed the loss of synaptophysin and calbindin (critical synaptic proteins, indicators of cognitive decline in AD) in the dentate gyrus, and the abnormal expression, in the hippocampus, of many genes involved in key neuronal signaling pathways...
April 6, 2017: Rejuvenation Research
https://www.readbyqxmd.com/read/28351218/association-among-serum-igf-1-frailty-muscle-mass-bone-mineral-density-and-physical-performance-among-community-dwelling-middle-aged-and-older-adults-in-taiwan
#4
Liang-Yu Chen, Yi-Hui Wu, Li-Kuo Liu, Wei-Ju Lee, An-Chun Hwang, Li-Ning Peng, Ming-Hsien Lin, Liang-Kung Chen
BACKGROUND: Aging is featured by the complex interrelationship between among body composition, frailty status and physical performance. The main aim of this study was to evaluate the association between among serum insulin-like growth factor-1 (IGF-1), body composition, and physical function among community-dwelling middle-aged and elderly population in Taiwan. METHODS: We conducted a cross-sectional study by using the data of I-Lan Longitudinal Aging Study (ILAS), which recruited a total of 1,833 community-dwelling people aged 50 years and older...
March 29, 2017: Rejuvenation Research
https://www.readbyqxmd.com/read/28193134/noncoronary-vascular-calcification-bone-mineral-density-and-muscle-mass-in-institutionalized-frail-nonagenarians
#5
Fernando Idoate, Eduardo L Cadore, Alvaro Casas-Herrero, Fabricio Zambom-Ferraresi, Nicolas Martínez-Velilla, Leocadio Rodriguez-Mañas, Pedro M Azcárate, Martim Bottaro, Robinson Ramírez-Vélez, Mikel Izquierdo
The purpose of this study was to compare the vascular calcification in thoracic aorta (TAC), abdominal aorta (AAC), iliac arteries (IAC), and femoral arteries (FAC) and bone mineral density (BMD) of the lumbar vertebrae between frail and robust nonagenarians, as well as to verify the associations between vascular calcification with BMD, muscle tissue quality, and quantity in both groups. Forty-two elderly subjects participated in this study: 29 institutionalized frail (92.0 ± 3.2 years) and 13 robust (89...
March 24, 2017: Rejuvenation Research
https://www.readbyqxmd.com/read/28162056/tanshinone-iia-elicits-neuroprotective-effect-through-activating-the-nuclear-factor-erythroid-2-related-factor-dependent-antioxidant-response
#6
Min Cai, Yongxin Guo, Shiquan Wang, Haidong Wei, Sisi Sun, Guangchao Zhao, Hailong Dong
Tanshinone IIA (TSA), a principal component derived from the Traditional Chinese Medicine Danshen has been suggested to exert neuroprotective effect against experimental cerebral ischemic/reperfusion injury. But the associated underlying mechanisms still have not been understood. The current study characterized the role of nuclear factor erythroid two-related factor-induced antioxidant response in the neuroprotective efficacy of TSA treatment. The focal cerebral ischemia/reperfusion model was established by 60-minute middle cerebral artery occlusion...
March 23, 2017: Rejuvenation Research
https://www.readbyqxmd.com/read/28162035/a-comparative-study-of-models-of-geriatric-assessment-and-the-implementation-of-recommendations-by-primary-care-physicians
#7
Ella Kagan, Tamar Freud, Boris Punchik, Alex Barzak, Roni Peleg, Yan Press
The aim of the present study was to compare implementation rates by primary care physicians of geriatric assessment recommendations given in various assessment settings. We compared Model "OCGAU", an outpatient comprehensive geriatric assessment unit where there was no direct contact between the geriatrician and the primary care physician with three "Clinic" models of in-clinic geriatric assessment: Model "Clinic A-2007" in which the primary care physician participated in the assessment, Model "Clinic A-2013" where there was no contact with the primary care physician, and Model "Clinics B-2013" where the primary care physician participated in a staff meeting with the geriatrician in the clinic...
March 20, 2017: Rejuvenation Research
https://www.readbyqxmd.com/read/28285577/the-in-vitro-influence-of-a-genetic-superoxide-hydrogen-peroxide-imbalance-on-immunosenescence
#8
Fernanda Barbisan, Verônica Farina Azzolin, Euler Esteves Ribeiro, Marta Maria Medeiros Frescura Duarte, Ivana Cruz
As superoxide is a key molecule of inflammatory activation, superoxide- hydrogen peroxide (S-HP) imbalance genetically caused could to alter immunosenescence patterns. To test this hypothesis, we collect and cultured peripheral blood mononuclear cells carrier´s different genotypes of a genetic polymorphism located in the superoxide dismutase manganese dependent gene (Val16Ala-SOD2). We used an in vitro genetic model based in prior studies, which suggested association between homozygous genotypes (AA and VV) and alterations in oxidative-inflammatory mediators...
March 12, 2017: Rejuvenation Research
https://www.readbyqxmd.com/read/28093038/metabonomic-strategy-for-the-evaluation-of-chinese-medicine-salvia-miltiorrhiza-and-dalbergia-odorifera-interfering-with-myocardial-ischemia-reperfusion-injury-in-rats
#9
Fei Mu, Jialin Duan, Haixu Bian, Xiaohu Zhai, Peijin Shang, Rui Lin, Meina Zhao, Dongmei Hu, Ying Yin, Aidong Wen, Miaomiao Xi
Extract of Salvia miltiorrhiza and Dalbergia Odorifera (SM-DOO) has been traditionally used for the prevention and treatment of cardiovascular diseases. However, information regarding the pharmacodyamic material basis and potential mechanism remain unknown. Male Sprague-Dawley rats were divided into four groups: Sham, Model, Diltiazem, and SM-DOO group, n = 6. Rats were pretreated with homologous drugs for 7 days, and then subjected to 30 minutes of ischemia followed by 180 minutes of reperfusion. Cardioprotection effects of SM-DOO on myocardial ischemia/reperfusion (MI/R) injury rats were examined by hemodynamics, infarct area, histopathology, biochemical indicators, and Western blot analysis...
March 7, 2017: Rejuvenation Research
https://www.readbyqxmd.com/read/28437187/synergy-between-choroid-plexus-epithelial-cells-conditioned-medium-and-knockout-serum-replacement-converts-human-adipose-derived-stem-cells-to-dopamine-secreting-neurons
#10
Mahdi Eskandarian Boroujeni, Mossa Gardaneh, Mehrnoosh Hasan Shahriari, Abbas Aliaghaei, Sanaz Hasani
Human adipose-derived stem cells (hADSCs) have great capacity to differentiate into mesodermal origins as well as non-mesodermal lineages including neural cells. This valuable feature paves the way for the therapeutic application of hADSCs for neurodegenerative maladies such as Parkinson's disease (PD). We tested the capacity of Choroid Plexus epithelial cells-conditioned medium (CPEC-CM) alone or cocktailed with knock-out serum (KS) to induce dopaminergic differentiation of hADSCs. To this end, hADSCs from lipoaspirate were phenotypically characterized and shown to maintain mesodermal multipotency so selected media easily differentiated them into osteoblasts, chondrocytes and adipocytes...
March 2, 2017: Rejuvenation Research
https://www.readbyqxmd.com/read/28056723/chronic-treatment-with-minoxidil-induces-elastic-fiber-neosynthesis-and-functional-improvement-in-the-aorta-of-aged-mice
#11
Marion Coquand-Gandit, Marie-Paule Jacob, Wassim Fhayli, Beatriz Romero, Miglena Georgieva, Stéphanie Bouillot, Eric Estève, Jean-Pierre Andrieu, Sandrine Brasseur, Sophie Bouyon, Natalio Garcia-Honduvilla, Philippe Huber, Julia Buján, Milena Atanasova, Gilles Faury
Normal arterial aging processes involve vascular cell dysfunction associated with wall stiffening, the latter being due to progressive elastin and elastic fiber degradation, and elastin and collagen cross-linking by advanced glycation end products (AGEs). These processes progressively lead to cardiovascular dysfunction during aging. Elastin is only synthesized during late gestation and childhood, and further degradation occurring throughout adulthood cannot be physiologically compensated by replacement of altered material...
March 1, 2017: Rejuvenation Research
https://www.readbyqxmd.com/read/28056664/protective-effect-of-sfe-co2-of-ligusticum-chuanxiong-hort-against-d-galactose-induced-injury-in-the-mouse-liver-and-kidney
#12
Zhi-Zhun Mo, Yu-Hong Liu, Cai-Lan Li, Lie-Qiang Xu, Ling-Ling Wen, Yan-Fang Xian, Zhi-Xiu Lin, Janis Ya-Xian Zhan, Jian-Nan Chen, Fang-Fang Xu, Zi-Ren Su
This study was designed to explore how supercritical fluid CO2 extract of Ligusticum chuanxiong Hort (CX) protects mouse liver and kidney from d-galactose-induced injury. The antioxidant capacity of CX was confirmed both in vitro and in vivo. The d-galactose-induced malondialdehyde increase was attenuated by CX, as well as the increase in aspartate aminotransferase, alanine aminotransferase, blood urea nitrogen, and creatinine level. In addition, the activities of antioxidant enzymes were markedly renewed, and the gene expressions of these enzymes were upregulated in CX groups...
February 23, 2017: Rejuvenation Research
https://www.readbyqxmd.com/read/27998213/mitochondrial-omi-htra2-promotes-caspase-activation-through-cleavage-of-hax-1-in-aging-heart
#13
Xin Liu, Jinghui Lei, Ke Wang, Lu Ma, Dan Liu, Yunhui Du, Ye Wu, Suli Zhang, Wen Wang, Xinliang Ma, Huirong Liu
Mitochondrial homeostasis is a key process involved in cellular destiny and organic function. When mitochondrial status is abnormal, it will become a "death motor." Impaired mitochondria lead to the release of cytochrome c, and then trigger mitochondria-induced caspase activation. Omi/HtrA2, a serine protease, locates in mitochondria and involves in mitochondrial homeostasis. Increased Omi/HtrA2 is observed in aging cardiac tissues, and whether this has effects on mitochondrial status has not been reported...
January 27, 2017: Rejuvenation Research
https://www.readbyqxmd.com/read/28346069/the-rationale-for-rejuvenation-research-structuring-the-debate
#14
Aubrey D N J de Grey
No abstract text is available yet for this article.
April 2017: Rejuvenation Research
https://www.readbyqxmd.com/read/28314379/rejuvenation-by-partial-reprogramming-of-the-epigenome
#15
Andrew R Mendelsohn, James W Larrick, Jennifer L Lei
Epigenetic variation with age is one of the most important hallmarks of aging. Resetting or repairing the epigenome of aging cells in intact animals may rejuvenate the cells and perhaps the entire organism. In fact, differentiated adult cells, which by definition have undergone some epigenetic changes, are capable of being rejuvenated and reprogrammed to create pluripotent stem cells and viable cloned animals. Apparently, such reprogramming is capable of completely resetting the epigenome. However, attempts to fully reprogram differentiated cells in adult animals have failed in part because reprogramming leads to the formation of teratomas...
April 2017: Rejuvenation Research
https://www.readbyqxmd.com/read/28298167/commentary-on-some-recent-theses-relevant-to-combating-aging-april-2017
#16
Benjamin Zealley, Aubrey D N J de Grey
No abstract text is available yet for this article.
April 2017: Rejuvenation Research
https://www.readbyqxmd.com/read/27841739/age-related-reduction-of-contractile-responses-to-urotensin-ii-is-seen-in-aortas-from-wistar-rats-but-not-from-type-2-diabetic-goto-kakizaki-rats
#17
Takayuki Matsumoto, Shun Watanabe, Shota Kobayashi, Makoto Ando, Kumiko Taguchi, Tsuneo Kobayashi
Vascular dysfunction is a common finding in type 2 diabetes, although the response to urotensin II (UII), a potent vasoconstrictor peptide, remains unclear. We investigated whether a UII-induced contraction was increased in the aortas from type 2 diabetic Goto-Kakizaki (GK) rats at the chronic stage. At 36 or 37 weeks of age (older group), a UII-induced contraction was seen in GK rats and was reduced by a Rho kinase inhibitor or urotensin receptor (UT) antagonist, whereas UII failed to induce a contraction in aortas from age-matched Wistar rats...
April 2017: Rejuvenation Research
https://www.readbyqxmd.com/read/27814668/orexin-a-protects-human-neuroblastoma-sh-sy5y-cells-against-6-hydroxydopamine-induced-neurotoxicity-involvement-of-pkc-and-pi3k-signaling-pathways
#18
Hamzeh Pasban-Aliabadi, Saeed Esmaeili-Mahani, Mehdi Abbasnejad
Parkinson's disease (PD) is a common neurodegenerative disorder that is characterized by progressive and selective death of dopaminergic neurons. Multifunctional neuropeptide orexin-A is involved in many biological events of the body. It has been shown that orexin-A has protective effects in neurodegenerative disease such as PD. However, its cellular mechanisms have not yet been fully clarified. Here, we investigated the intracellular signaling pathway of orexin-A neuroprotection in 6-hydroxydopamine (6-OHDA)-induced SH-SY5H cells damage as an in vitro model of PD...
April 2017: Rejuvenation Research
https://www.readbyqxmd.com/read/27796163/bioimpedance-derived-phase-angle-and-mortality-among-older-people
#19
Laurence Genton, Kristina Norman, Adrian Spoerri, Claude Pichard, Véronique L Karsegard, François R Herrmann, Christophe E Graf
BACKGROUND: Phase angle measured by bioelectrical impedance analysis (BIA) may be a marker of health state. OBJECTIVE: This historical cohort study of prospectively collected BIA measurements aims to investigate the link between phase angle and mortality in older people and evaluate whether a phase angle cutoff can be defined. DESIGN: We included all adults aged ≥65 years who underwent a BIA measurement by the Nutriguard(®) device at the Geneva University Hospitals...
April 2017: Rejuvenation Research
https://www.readbyqxmd.com/read/27651115/urinary-incontinence-and-its-association-with-frailty-among-men-aged-80-years-or-older-in-taiwan-a-cross-sectional-study
#20
Chih-Jen Wang, Cheng-Hao Hung, Ting-Ching Tang, Liang-Yu Chen, Li-Ning Peng, Fei-Yuan Hsiao, Liang-Kung Chen
AIMS: To evaluate the prevalence of urinary incontinence (UI) and its association with frailty among men aged 80 years and older in Taiwan. METHODS: Residents living in four veterans retirement communities were invited for study and 440 men aged 80 years and older were enrolled. Comprehensive geriatric assessment was performed for them, which composed of Clinical Frailty Scale, Northern Health and Social Care Trust (HSC)-Continence Assessment Form, Charlson's Comorbidity Index (CCI), Barthel Index (BI), Instrumental Activities of Daily Living (IADL), Mini-Mental State Examination (MMSE), Geriatric Depression Scale-5 (GDS-5), and Mini-Nutritional Assessment-Short Form (MNA-SF)...
April 2017: Rejuvenation Research
journal
journal
40675
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"