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Rejuvenation Research

Aubrey D N J de Grey
October 12, 2016: Rejuvenation Research
Benjamin Zealley, Aubrey D N J de Grey
No abstract text is available yet for this article.
October 11, 2016: Rejuvenation Research
James W Larrick, Jasmine W Larrick, Andrew R Mendelsohn
The loss of muscle stem cell (MuSC) numbers and function in the elderly results in a dramatic delay or incomplete repair of muscle following injury or surgery. Prolonged immobility can exacerbate the loss of muscle mass with increased morbidity of affected patients. Stem cells and their niche cooperate to regulate the activation, self-renewal, differentiation, and return to quiescence of MuSCs. Extracellular matrix fibronectin (FN) and MuSC β1-integrin have been identified as critical factors in the dysfunction of aging muscle...
October 11, 2016: Rejuvenation Research
Chih-Jen Wang, Cheng-Hao Hung, Ting-Ching Tang, Liang-Yu Chen, Li-Ning Peng, Fei-Yuan Hsiao, Liang-Kung Chen
AIMS: To evaluate the prevalence of urinary incontinence (UI) and its association with frailty among men aged 80 years and older in Taiwan METHODS: Residents living in four veterans retirement communities were invited for study and 440 men aged 80 years and older weer enrolled. Comprehensive geriatric assessment was performed for them, including using the following measurements: Clinical Frailty Scale, Northern Health and Social Care Trust (HSC)-Continence Assessment Form, Charlson's Comorbidity Index (CCI), Barthel Index (BI), Instrumental Activities of Daily Living (IADL), Mini-Mental State Examination (MMSE), Geriatric Depression Scale-5 (GDS-5), Mini-Nutritional Assessment-Short Form (MNA-SF)...
September 21, 2016: Rejuvenation Research
Aubrey D N J de Grey
No abstract text is available yet for this article.
September 14, 2016: Rejuvenation Research
Aubrey D N J de Grey
No abstract text is available yet for this article.
August 2016: Rejuvenation Research
(no author information available yet)
No abstract text is available yet for this article.
August 2016: Rejuvenation Research
James W Larrick, Jasmine W Larrick, Andrew R Mendelsohn
Until recently, the mechanism of adaptive thermogenesis was ascribed to the expression of uncoupling protein 1 (UCP1) in brown and beige adipocytes. UCP1 is known to catalyze a proton leak of the inner mitochondrial membrane, resulting in uncoupled oxidative metabolism with no production of adenosine triphosphate and increased energy expenditure. Thus increasing brown and beige adipose tissue with augmented UCP1 expression is a viable target for obesity-related disorders. Recent work demonstrates an UCP1-independent pathway to uncouple mitochondrial respiration...
August 2016: Rejuvenation Research
Michael D Burton, Jennifer L Rytych, Ravi Amin, Rodney W Johnson
Brain microglia become dysregulated during aging and express proinflammatory cytokines that play a role in cognitive aging. Recent studies suggest the flavonoid luteolin reduces neuroinflammation and improves learning and memory in aged mice. However, if dietary luteolin reduces microglia activity in the brain of senescent mice is not known. We hypothesized that feeding aged mice a diet with luteolin would reduce microglia activity. Adult (3-6 months) and aged (22-24 months) mice were fed American Institute of Nutrition (AIN)-93M or AIN-93M with luteolin (6 g/kg) for 4 weeks and injected intraperitoneally with saline or lipopolysaccharide (LPS) before microglia were isolated and stained for major histocompatibility complex (MHC) class II, interleukin (IL)-1β, and IL-6 for flow cytometry...
August 2016: Rejuvenation Research
Rebeccah A Warmack, Eduardo Mansilla, Rodolfo G Goya, Steven G Clarke
The quantification of aspartic acid racemization in the proteins of nonmetabolically active tissues can be used as a measure of chronological aging in humans and other long-lived organisms. However, very few studies have been conducted in shorter-lived animals such as rodents, which are increasingly used as genetic and metabolic models of aging. An initial study had reported significant changes in the ratio of d- to l-aspartate in rat molars with age. Using a sensitive HPLC method for the determination of d- and l-aspartate from protein hydrolysates, we found no accumulation of d-aspartate in the molars of 17 rats that ranged in age from 2 to 44 months, and the amount of d-aspartate per molar did not correspond with molar eruption date as had been previously reported...
August 2016: Rejuvenation Research
Eduardo Mansilla, Gustavo Roque, Yolanda E Sosa, Adrian Tarditti, Rodolfo G Goya
There is a growing interest in the potential of mesenchymal stem cells (MSCs) for implementing regenerative medicine. We assessed the effect of intravenous administration of human bone marrow-derived MSC on the life span of a single Sprague-Dawley female rat. The treatment was started when the rat was 6 months old and the cells were administered every 2 weeks afterward. The treatment did not induce any obvious changes in body growth or behavior and the rat showed the typical age changes for this strain, except that, unlike intact counterparts, the animal did not develop mammary tumors or pituitary gland hyperplasia...
August 2016: Rejuvenation Research
Francesco Albert Bosco Cortese, Giovanni Santostasi
In both biomedicine in general and biomedical gerontology in particular, cell replacement therapy is traditionally proposed as an intervention for cell loss. This article presents a proposed intervention-whole-body induced cell turnover (WICT)-for use in biomedical gerontology that combines cell replacement therapy with a second therapeutic component (targeted cell ablation) so as to broaden the therapeutic utility of cell therapies and increase the categories of age-related damage that are amenable to cell-based interventions...
August 2016: Rejuvenation Research
Hao-Bin Cai, Guang-Liang Wu, Cen-Han Huang, Zhong-Shi Huang, Yun-Bo Chen, Qi Wang
With the average life span of humans on the rise, aging in the world has drawn considerable attentions. The monoamine neurotransmitters and neurotrophic factors in brain areas are involved in learning and memory processes and are an essential part of normal synaptic neurotransmission and plasticity. In the present study, the effect of Zhuang Jing Decoction (ZJD) on the learning and memory ability in aging rats was examined in vivo using Morris water maze. Furthermore, the levels of monoamine neurotransmitters and neurotrophic factors in brain were detected by high-performance liquid chromatography with a fluorescence detector and enzyme-linked immunosorbent assay, respectively...
August 2016: Rejuvenation Research
An-Yun Guo, Kwok-Sui Leung, Jiang-Hui Qin, Simon Kwoon-Ho Chow, Wing-Hoi Cheung
Sarcopenia-related falls and fall-related injuries in community-dwelling elderly people garnered more and more interest in recent years. Low-magnitude high-frequency vibration (LMHFV) was proven beneficial to musculoskeletal system and recommended for sarcopenia treatment. This study aimed to evaluate the effects of LMHFV on the sarcopenic animals and explore the mechanism of the stimulatory effects. Senescence-accelerated mouse P8 (SAMP8) mice at month 6 were randomized into control (Ctrl) and vibration (Vib) groups and the mice in the Vib group were given LMHFV (0...
August 2016: Rejuvenation Research
Jintanaporn Wattanathorn, Chatchada Sutalangka
Based on pivotal roles of oxidative stress, dopaminergic and cholinergic systems on the pathophysiology of Parkinson's disease (PD), the searching for functional food for patients attacked with PD from Cyperus rotundus and Zingiber officinale, the substances possessing antioxidant activity, and the suppression effects on monoamine oxidase B (MAO-B) and acetylcholinesterase (AChE) have been considered. In this study, we aimed to determine the effect of the combined extract of C. rotundus and Z. officinale (CP1) to improve motor and memory deficits, neurodegeneration, oxidative stress, and functions of both cholinergic and dopaminergic systems in the animal model of PD induced by 6-hydroxydopamine hydrochloride (6-OHDA)...
August 2016: Rejuvenation Research
Léa Moulin, Valérie Cenizo, Alengo Nyamay Antu, Valérie Andre-Frei, Sabine Pain, Pascal Sommer, Romain Debret
Lysyl oxidase-like 1 (LOXL1) is an amino-oxidase involved in maturation of elastic fibres. Its downregulation has been associated with elastic fibres repair loss in ageing aorta, lung, ligament and skin. Several evidences of LOXL1 epigenetic silencing by promoter methylation were reported in cancer and cutis laxa syndrome. We hypothesised that this mechanism could be implicated in skin ageing process, as far as elastic fibres are also concerned. Anti-DNMT3A chromatin immuno-precipitation was conducted with nuclear extracts from skin fibroblasts isolated from young and elderly individuals, and showed a higher level of DNMT3A protein binding to the LOXL1 promoter in older cells concomitantly to the decrease of LOXL1 mRNA expression and the increase of LOXL1 promoter methylation...
July 10, 2016: Rejuvenation Research
Erik Paul Rader, Marshall A Naimo, Kayla N Layner, Alyssa M Triscuit, Robert D Chetlin, James Ensey, Brent A Baker
Exercise is the most accessible, efficacious, and multifactoral intervention to improve health and treat chronic disease. High-intensity resistance exercise, in particular, also maximizes skeletal muscle size and strength - outcomes crucial at advanced age. However, such training is capable of inducing muscle maladaptation when misapplied at old age. Therefore, characterization of parameters (e.g. mode and frequency) which foster adaptation is an active research area. To address this issue, we utilized a rodent model that allowed training at maximal intensity in terms of muscle activation and tested the hypothesis that muscles of old rats adapt to stretch-shortening contraction training, provided the training frequency is sufficiently low...
July 5, 2016: Rejuvenation Research
Yanlian Xiong, Yanlei Xiong, Shuai Zhou, Yanan Sun, Xiaotong Ren, Yuqi Zhao, Yingfang Zhang, Naili Zhang
BACKGROUND/AIMS: The main purpose of the present study was to investigate the effects of vitamins C and E supplements on the antioxidant capacity of erythrocytes obtained from young and aged rats. METHODS: Male Wistar rats aged 3 and 24 months were used. Vitamins C and E were injected at doses of 200mg/kg/day intraperitoneal in young and aged groups. The antioxidant capacity, oxidant stress parameters and deformability of red blood cells collected from different age stages were evaluated...
June 26, 2016: Rejuvenation Research
Qiang Hui, Peng Chang, Bingyu Guo, Yu Zhang, Kai Tao
Ultra-pulsed fractional CO2 laser is an efficient, precise, and safe therapeutic intervention for skin refreshing, although accompanied with prolonged edema and erythema. In recent years, autologous platelet-rich plasma (PRP) has been proven to promote wound and soft tissue healing and collagen regeneration. To investigate whether the combination of PRP and ultra-pulsed fractional CO2 laser had a synergistic effect on therapy for facial rejuvenation. Totally, 13 facial aging females were treated with ultra-pulsed fractional CO2 laser...
June 23, 2016: Rejuvenation Research
Geetika Garg, Sandeep Singh, Abhishek Kumar Singh, Syed Ibrahim Rizvi
Metformin, a biguanide drug commonly used to treat type 2 diabetes, has been noted to function as a caloric restriction mimetic. Its antidiabetic effect notwithstanding, metformin is currently being considered an antiaging drug candidate, although the molecular mechanisms have not yet been unequivocally established. This study aims to examine whether short-term metformin treatment can provide protective effects against oxidative stress in young and old-age rats. Young (age 4 months) and old (age 24 months) male Wistar rats were treated with metformin (300 mg/kg b...
June 23, 2016: Rejuvenation Research
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