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Rejuvenation Research

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https://www.readbyqxmd.com/read/30009679/postsynaptic-glur2-involved-in-amelioration-of-a%C3%AE-induced-memory-dysfunction-by-kaixin-san-through-rescuing-hippocampal-ltp-in-mice
#1
Bo Zhang, Yan Li, Jiawei Liu, Xuewei Liu, Wei Wen, Yu Cui, Shuming Huang
Kaixin-San (KXS), a Chinese formula, was used to treat "amnesia", a senile dementia in the modern world. This formula was reported to improve behavioral performances in many animal models. This study was designed to explore how KXS has improved amyloid-β (Aβ)-induced memory dysfunction in mice. The mouse models were achieved through unilateral ventricle injection with Aβ42. The effects of KXS on memory improvement was evaluated by step-down test. The electrophysiological changes induced by KXS were measured by long-term potentiation (LTP) analysis in the hippocampus in vivo...
July 16, 2018: Rejuvenation Research
https://www.readbyqxmd.com/read/29962322/the-effects-of-light-and-moderate-intensity-exercise-on-the-femoral-bone-and-cerebellum-of-d-galactose-exposed-rats
#2
Ginus Partadiredja, Nisa Karima, Kurnia Putri Utami, Denny Agustiningsih, Zaenal Muttaqien Sofro
Ageing causes the degeneration of organs of the locomotor system, including the cerebellum and bones. Exercise may reverse this deterioration. D-galactose has been frequently used in rodents to accelerate ageing. The present study aimed at investigating the effects of exercise on cerebellar and serum growth factors, motor activity, and the number of bone cells of the femoral head of D-galactose-treated rats. Twenty-four male Wistar rats were divided randomly into four groups, i.e. three treated groups injected with 300 mg/ml/kg bw D-galactose solution daily for 4 weeks, and a control group injected with normal saline...
July 1, 2018: Rejuvenation Research
https://www.readbyqxmd.com/read/29962320/effect-of-treadmill-walking-on-leg-muscle-activation-in-parkinson-s-disease
#3
Olalla Bello, Gonzalo Márquez, Miguel Fernández Del Olmo
Treadmills are often employed as rehabilitation devices to improve gait in Parkinson's disease (PD). Kinematic differences between treadmill and overground gait have been reported. However, electromyographic (EMG) patterns during treadmill and overground walking have not been systematically compared. The aim of this study was to assess the effects of treadmill gait on the magnitude of the EMG activity of the lower limb muscles in PD. We measured EMG activity of the tibialis anterior (TA), gastrocnemius medialis (GM), vastus lateralis (VL) and biceps femoris (BF) of 9 individuals with PD and 9 healthy matched controls...
July 1, 2018: Rejuvenation Research
https://www.readbyqxmd.com/read/29962294/stem-cell-induced-pulp-regeneration-can-be-enhanced-by-administration-of-ccl11-neutralizing-antibody-in-the-ectopic-tooth-transplantation-model-in-the-aged-mice
#4
Yuki Hayashi, Ray Kawamura, Shin Nishimatu, Osamu Fukuta, Misako Nakashima
OBJECTIVE: Pulp regeneration by stem cell transplantation declines due to age-related reduction in proliferation, migration and anti-apoptotic activities of surrounding tissue-derived resident stem cells. We hypothesized that administration of a cytokine together with the cell transplantation may improve the stem cell niche microenvironment and promote regeneration. CCL11/Eotaxin is implicated as a factor in aging. This investigation was performed to investigate the changes in the quality and quantity of the regenerated pulp by administration of CCL11 antibody in the aged mice and elucidate the underlying mechanisms...
July 1, 2018: Rejuvenation Research
https://www.readbyqxmd.com/read/29943667/rapamycin-confers-neuroprotection-against-aging-induced-oxidative-stress-mitochondrial-dysfunction-and-neurodegeneration-in-old-rats-via-activation-of-autophagy
#5
Abhishek Kumar Singh, Sandeep Singh, Vinay Kumar Tripathi, Akalabya Bissoyi, Geetika Garg, Syed Ibrahim Rizvi
Brain aging is an intricate and natural phenomenon exclusively characterized by oxidative stress, accumulation of oxidatively damaged macromolecules, and alterations in structure and function of neurons that further increase the risk factor for most of the neurodegenerative diseases. In addition, age-dependent defective autophagy has also been implicated to favour the pathogenesis and prevalence of the neurological diseases. Therefore, the development of strategies that delay aging and the concomitant neurological disorders remain elusive...
June 26, 2018: Rejuvenation Research
https://www.readbyqxmd.com/read/29932015/stat3-c-myc-axis-mediated-metabolism-alternations-of-inflammation-related-glycolysis-involves-with-colorectal-carcinogenesis
#6
Sha Zhang, Jie Li, Pei Xie, Ting Zang, Haibin Shen, Guochun Cao, Ying Zhu, Zhenggang Yue, Zhe Li
Chronic inflammation is a major driving factor for the development of colitis-associated cancer (CAC). It is extensively acknowledged that patients who have long-standing inflammation bowel disease (IBD) are at high risk for developing CAC. However, the metabolic alteration by which chronic intestinal inflammation promotes colorectal cancer is unclear. In the present study, we constructed dextran sulfate sodium (DSS)-induced chronic colitis mouse model to uncover possible alterations in the metabolism indexes...
June 22, 2018: Rejuvenation Research
https://www.readbyqxmd.com/read/29926769/review-of-scientific-self-experimentation-ethics-history-regulation-scenarios-and-views-among-ethics-committees-and-prominent-scientists
#7
Brian P Hanley, William Bains, George Church
We examine self-experimentation ethics history and practice, related law, use scenarios in universities and industry, and attitudes. We show through analysis of the historical development of medical ethics and regulation, from Hippocrates through Good Clinical Practice that there are no ethical barriers to self-experimentation. When the self-experimenter is a true investigator, there is no other party to be protected from unethical behavior. We discuss the n-of-1 issue in self-experiments, and make suggestions for improving experiment design...
June 21, 2018: Rejuvenation Research
https://www.readbyqxmd.com/read/29717617/selegiline-nanoformulation-in-attenuation-of-oxidative-stress-and-upregulation-of-dopamine-in-the-brain-for-the-treatment-of-parkinson-s-disease
#8
Shobhit Kumar, Shweta Dang, Kudeep Nigam, Javed Ali, Sanjula Baboota
Objective of this study was to determine whether the prepared nanoemulsion would be able to deliver selegiline to the brain by intranasal route, improving its bioavailability. Antioxidant activity, pharmacokinetic parameters, and dopamine concentration were determined. Oxidative stress models, which had Parkinson's disease-like symptoms, were used to evaluate the antioxidant activity of nanoemulsion loaded with selegiline in vivo. The antioxidant activity was evaluated by 1,1-diphenyl-2-picryl-hydrazyl (DPPH) assay and reducing power assay, which showed high scavenging efficiency for selegiline nanoemulsion compared to pure selegiline...
June 21, 2018: Rejuvenation Research
https://www.readbyqxmd.com/read/29911505/filling-procedures-for-lip-and-perioral-rejuvenation-a-systematic-review
#9
Michele Pascali, Davide Quarato, Francesco Carinci
The ideal perioral and lip rejuvenation technique provides the longest period of efficacy, lowest complication rate, and best aesthetic results. Genetics, intrinsic aging, sun exposure and repetitive muscle twitching of the orbicularis oris produce angular, radial, and vertical lines of the perioral lines and, for this reason, the needs of patients in the treatment of this anatomical area can range from simple lip enhancement to a broader and more comprehensive treatment with simultaneous correction of perioral wrinkles...
June 18, 2018: Rejuvenation Research
https://www.readbyqxmd.com/read/29911496/multicomponent-training-program-with-high-speed-movement-execution-of-ankle-muscles-reduce-risk-of-falls-in-older-adults
#10
Roberta Castilhos Detanico Bohrer, Gleber Pereira, Joice Katiane Mendes Beck, Angélica Lodovico, André Rodacki
The purpose of this study was to investigate the effects of multicomponent training program, designed to improve the torque around the ankle joint performing high-speed movement execution, on healthy older adults. Participants were balanced by torque around the ankle joint and randomly allocated to either exercise (n=12, 69.7±4.8 years, 74.6±16.8 kg, 1.63±0.10 m) or control group (n=14, 70.86±6.48 years; 73.5±13.4 kg, 1.56±0.05 m). The exercise group performed a multicomponent training of resistance, agility and coordination exercises, focusing on the plantar flexor muscles during 12 weeks (3 days per week)...
June 18, 2018: Rejuvenation Research
https://www.readbyqxmd.com/read/29911492/nocturnal-hypoventilation-may-have-a-protective-effect-for-ischemic-heart-disease-in-obesity-hypoventilation-syndrome
#11
Giorgio Castellana, Silvano Dragonieri, Lorenzo Marra, Vitaliano Quaranta, Pierluigi Carratù, Teresa Ranieri, Onofrio Resta
BACKGROUND: The importance of nocturnal hypoventilation in the development of cardiovascular comorbidity (CVM) in patients with Obesity Hypoventilation Syndrome (OHS) is controversial. We recently hypothesized that nocturnal hypoventilation may have a protective effect on cardiovascular comorbidity in OHS. AIM: The aim of this study was to evaluate the link between nocturnal hypoventilation (nHyp) and CVM in patients with OHS. METHODS: We performed a retrospective analysis of the clinical records of 60 patients with OHS...
June 18, 2018: Rejuvenation Research
https://www.readbyqxmd.com/read/29886815/a-high-intensity-jump-based-aquatic-exercise-program-improves-bone-mineral-density-and-functional-fitness-in-postmenopausal-women
#12
Antonio Michel Aboarrage Junior, Caue V La Escala Teixeira, Rodrigo N Santos, Alexandre F Machado, Alexandre L Evangelista, Roberta L Rica, Angelica C Alonso, Andrey J Serra, José Ailton Barroso, Julien S Baker, Danilo Sales Bocalini
The aim of this study was to verify the effects of a high-intensity jump-based aquatic exercise program (HIIAE) on bone mass and functional fitness of postmenopausal women. METHODS: We randomly assigned 20 women (65 ± 7 years) into two groups: Training (T, n=12) and Untrained (Un, n=8). Only the T group was submitted to 24 weeks of a HIIAE program, where each session lasted for 30 minutes. The following parameters were assessed before and 6 months following the intervention: bone and physical fitness; lumbar spine (LS) , total femur (TF) and whole body (WB) bone mineral density (BMD); as well as agility (Timed up-and-go, TUG), and leg strength (chair stand test, CS) Results: We observed a significant increase (p<0,01) in LS, (Un: -0...
June 11, 2018: Rejuvenation Research
https://www.readbyqxmd.com/read/29847217/functional-drink-containing-the-extracts-of-purple-corn-cob-and-pandan-leaves-the-novel-cognitive-enhancer-increases-spatial-memory-and-hippocampal-neuron-density-through-the-improvement-of-extracellular-signal-regulated-protein-kinase-expression-cholinergic
#13
Jintanaporn Wattanathorn, Woranan Kirisattayakul, Bhalang Suriharn, Kamol Lertrat
Due to requirement of novel memory enhancer for menopausal women, this study aimed to determine safety and effect of the functional drink containing the extracts of purple corn cob and pandan leaves (PCP) on memory and brain changes in experimental menopause induced by bilateral ovariectomy (OVX). Acute toxicity of PCP was carried out in female Wistar rats. The results showed that LD50 was more than 2000 mg/kg BW. To determine the cognitive enhancing effect of PCP, OVX rats were orally treated with PCP at the doses of 20, 40, and 80 mg/kg BW for 28 days...
May 30, 2018: Rejuvenation Research
https://www.readbyqxmd.com/read/29651925/heptamer-peptide-disassembles-native-amyloid-in-human-plasma-through-heat-shock-protein-70
#14
Timothy J Cunningham, Jeffrey Greenstein, Lihua Yao, Itzhak Fischer, Theresa Connors
Proteostasis, which includes the repair and disposal of misfolded proteins, depends, in part, on the activity of heat shock proteins (HSPs), a well-known class of chaperone molecules. When this process fails, abnormally folded proteins may accumulate in cells, tissues, and blood. These species are a hallmark of protein aggregation diseases, but also amass during aging, often in the absence of an identified clinical disorder. We report that a neuroprotective cyclic heptapeptide, CHEC-7, which has been applied systemically as a therapeutic in animal neurodegeneration models, disrupts such aggregates and inhibits amyloidogenesis when added in nanomolar concentrations to human plasma...
May 30, 2018: Rejuvenation Research
https://www.readbyqxmd.com/read/29669458/effects-of-dance-exergaming-on-depressive-symptoms-fear-of-falling-and-musculoskeletal-function-in-fallers-and-nonfallers-community-dwelling-older-women
#15
Elisângela Valevein Rodrigues, Luiza Herminia Gallo, Ana Tereza Bittencourt Guimarães, Jarbas Melo Filho, Bruna Cavon Luna, Anna Raquel Silveira Gomes
The aim of this study was to evaluate the effects of a pop dance exergaming protocol on fall risk factors-depressive symptoms, fear of falling, and musculoskeletal function-in community-dwelling older female fallers and nonfallers. There were 47 community-dwelling older women assigned to the intervention group (IG) [fallers (n = 10, 69.8 ± 4.3 years); nonfallers (n = 12, 68.9 ± 3.3 years)] and the control group (CG) [fallers (n = 12, 73.6 ± 5.4 years); nonfallers (n = 13, 68.7 ± 4...
May 29, 2018: Rejuvenation Research
https://www.readbyqxmd.com/read/29804491/uplc-q-tof-ms-based-metabonomics-revealed-protective-effect-of-terminalia-chebula-extract-on-ischemic-stroke-rats
#16
Wenxing Liu, Fei Mu, Tianlong Liu, Hang Xu, Jianzhong Chen, Na Jia, Yikai Zhang, Fang Dou, Lei Shi, Yuwen Li, Aidong Wen, Yi Ding
Terminalia chebula (TC), a kind of Combretaceae, is a widely used herb in India and East Asia to treat cerebrovascular diseases. However, the potential mechanism of the neuroprotective effects of TC at the metabonomics level is still not unclear. The present study focused on the effects of TC on metabonomics in stroke model. In our study, rats were divided randomly into Sham, Model, and TC groups. The TC group were intragastricly administered with TC for 7 days after middle cerebral artery occlusion (MCAO) operation...
May 28, 2018: Rejuvenation Research
https://www.readbyqxmd.com/read/29644926/role-of-ligands-of-receptor-for-advanced-glycation-end-products-rage-in-peripheral-artery-disease
#17
Sho-Ichi Yamagishi, Takanori Matsui
Atherosclerotic cardiovascular disease, including peripheral artery disease (PAD), is more common and severe in diabetic patients compared with nondiabetic individuals. Indeed, diabetes is associated with the increased risk of limb amputation and all-cause mortality in patients with symptomatic PAD. Proteins and lipids are nonenzymatically modified by sugars, resulting in the formation and accumulation of advanced glycation end products (AGEs), whose process is accelerated under diabetic conditions, especially patients with a long duration of diabetes...
May 21, 2018: Rejuvenation Research
https://www.readbyqxmd.com/read/29756514/ilex-paraguariensis-extends-lifespan-and-increases-an-ability-to-resist-environmental-stresses-in-drosophila
#18
Prakshit Niraula, Saurav Ghimire, Hanna Lee, Man Su Kim
Aging is a complex process resulting in: i) a decline in body functions and capacity to withstand environmental stress and ii) an increased susceptibility to diseases including, but not limited to, cardiovascular disorders, diabetes, cancer and dementia. Among a number of herbal products used to alleviate symptoms associated with aging is Ilex paraguariensis (IP). This product has been reported to have anticancer, anti-inflammatory and antioxidant activities. However, its effect on an organisms' longevity has not been thoroughly studied to date...
May 14, 2018: Rejuvenation Research
https://www.readbyqxmd.com/read/29695187/restoring-nad-levels-with-nad-intermediates-the-second-law-of-thermodynamics-and-aging-delay
#19
Borut Poljsak, Irina Milisav
The hypothesis regarding the role of increased nicotinamide adenine dinucleotide (NAD+) levels with reference to the fundamental concepts of ageing and entropy is presented. Considering the second law of thermodynamics, NAD+ seems the appropriate candidate for reversing many aging-associated pathologies. NAD+ is presented as an essential compound that enables organisms to stay highly organized and well-maintained, with a lower entropy state.
April 26, 2018: Rejuvenation Research
https://www.readbyqxmd.com/read/29845890/-rejuvenation-reclaimed
#20
Aubrey D N J de Grey
No abstract text is available yet for this article.
June 2018: Rejuvenation Research
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