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Rejuvenation Research

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https://www.readbyqxmd.com/read/28548620/baicalein-exerts-beneficial-effects-in-d-galactose-induced-aging-rats-through-attenuation-of-inflammation-and-metabolic-dysfunction
#1
Dan-Dan Duan, Ke Xin Wang, Yu-Zhi Zhou, Xue-Mei Qin, Li Gao, Guan-Hua Du
Baicalein is a flavonoid isolated from the roots of Scutellaria baicalensis Georgi. This study aimed to ascertain the effects and potential underlying mechanisms of baicalein in D-galactose induced aging rat model by integration of behavior examination, biochemical detection and 1H NMR based metabolomic approach. Our findings suggest that baicalein significantly attenuated memory decline in D-galactose induced aging model, as manifested by increasing recognition index in novel object recognition test, shortening latency time and increasing platform crossings in morris water maze test...
May 26, 2017: Rejuvenation Research
https://www.readbyqxmd.com/read/28537525/when-hypnosis-beats-logic-a-demoralising-geographical-coincidence
#2
Aubrey D N J de Grey
n/a.
May 24, 2017: Rejuvenation Research
https://www.readbyqxmd.com/read/28537507/electroacupuncture-alleviated-brain-damages-through-mir-191a-5p-targeting-neuronal-calcium-sensor-1-after-ischemic-stroke
#3
Heng Zhou, Ceng Yang, Fuhai Bai, Zhi Ma, Jingyi Wang, Feng Wang, Feng Li, Qiang Wang, Lize Xiong
Electroacupuncture (EA) administration before or after cerebral ischemia has been shown to afford protection against ischemic injury. However, the underlying mechanism of EA-mediated protection is still unclear. Functional microRNAs (miRNAs) are believed to play important roles in neuroprotection and synaptic plasticity during and after ischemia. In a previous study, we identified 20 miRNAs that are expressed in the penumbra and are significantly changed after EA treatment. Here, we used bioinformatics analysis to predict the biological functions and gene-networks of these miRNAs...
May 24, 2017: Rejuvenation Research
https://www.readbyqxmd.com/read/28537485/a-nad-parp1-sirt1-axis-in-aging
#4
Andrew R Mendelsohn, James Larrick
NAD+ levels decline with age in diverse animals from C. elegans to mice. Raising NAD+ levels by dietary supplementation with NAD+ precursors NR or NMN improves mitochondrial function and muscle, neural and melanocyte stem cell function in mice as well as increasing murine lifespan. Decreased NAD+ levels with age reduces SIRT1 function and reduces the mitochondrial unfolded protein response, which can be overcome by NR supplementation. Decreased NAD+ levels cause NAD+-binding protein DCB1 to form a complex with PARP1, inhibiting PARP catalytic activity...
May 24, 2017: Rejuvenation Research
https://www.readbyqxmd.com/read/28446042/the-use-of-fibroblasts-for-ameliorating-structural-changes-associated-with-skin-aging
#5
Toshimitsu Itaya, Tatsuo Hirai, Takahisa Hirai, Hideki Numoto, Hideo Takeda, Minoru Ueda
Various causes underlie the structural changes associated with skin aging. To treat these problems, surgical or nonsurgical approaches are available. One of the nonsurgical approaches-regeneration therapy-has become the focus of research and clinical applications. In an earlier clinical study, we injected fibroblasts into the nasolabial region and lips to counter the structural changes associated with skin aging. Assessments performed 12 months after the first injection showed mostly adequate satisfaction scores...
May 24, 2017: Rejuvenation Research
https://www.readbyqxmd.com/read/28514891/synergistic-effect-of-rapamycin-and-metformin-against-age-dependent-oxidative-stress-in-rat-erythrocyte
#6
Abhishek Kumar Singh, Geetika Garg, Sandeep Singh, Syed Ibrahim Rizvi
Erythrocytes are particularly vulnerable towards age-dependent oxidative stress mediated damage. Caloric restriction mimetics (CRMs) may provide a novel strategy for the maintenance of redox balance as well as effective treatment of age associated diseases. Herein, we have investigated the beneficial effect of co-treatment of CRM-candidate drugs, rapamycin (an immunosuppressant drug and inhibitor of mammalian target of rapamycin) and metformin (an anti-diabetic biguanide and activator of adenosine monophosphate kinase) against aging-induced oxidative stress in erythrocytes and plasma of aging rats...
May 17, 2017: Rejuvenation Research
https://www.readbyqxmd.com/read/28514191/commentary-on-some-recent-theses-relevant-to-combating-aging-june-2017
#7
Benjamin Zealley, Aubrey D N J de Grey
n/a.
May 17, 2017: Rejuvenation Research
https://www.readbyqxmd.com/read/28514190/criterion-referenced-fitness-standards-associated-with-maintaining-functional-capacity-in-chilean-older-adults
#8
Eugenio Merellano-Navarro, Daniel Collado-Mateo, Javier García-Rubio, Narcís Gusi, Pedro R Olivares
The aim of the current study was to develop fitness standards associated with maintaining physical capacity in older adults at two different levels - that needed for advanced functioning and that needed for maintaining moderate (independent) functional ability. Cross-sectional study of 406 Chilean adults aged 60 and more. Functional capacity was measured via the Composite Physical Function scale (CPF). A battery of validated fitness tests for this population was used. Based on the results of the CPF, two variables were created: "advanced physical capacity" (defined as those scoring 24 on the CPF scale) and "moderate (independent) physical capacity," defined as those scoring between 14 and 23 on the CPF scale...
May 17, 2017: Rejuvenation Research
https://www.readbyqxmd.com/read/28398133/combined-effect-of-obesity-and-mobility-limitation-with-incidence-of-type-2-diabetes-and-mortality-in-chinese-elderly
#9
Li Kang, Liye Jia, Peipei Han, Wen Zhang, Yixuan Ma, Liyuan Fu, Hairui Yu, Xiaoyu Chen, Lu Wang, Lin Hou, Xing Yu, Jianing Song, Ruiming He, Hui Li, Tingting Miao, Xiaolong Yang, Kaijun Niu, Liancheng Wang, Qi Guo
This article aims to examine the effect of mobility limitation and obesity on the risk of new incidence of type 2 diabetes mellitus (T2DM) and mortality. The design was a cohort study (n = 1075) among adults aged 60 years and older. Obesity was defined as body-mass index greater than or equal to 28 kg/m(2). Mobility limitation was defined as participants scoring in the top 20% on the timed up and go test or in the slowest 20% for the 4-m walking test. The mean age of the study population was 67.4 ± 5...
May 17, 2017: Rejuvenation Research
https://www.readbyqxmd.com/read/28498065/effect-of-interval-and-continuous-aerobic-training-on-basal-serum-and-plasma-bdnf-values-in-seniors-a-systematic-review-of-intervention-studies
#10
Lievyn Enette, Thomas Vogel, Jean Luc Fanon, Pierre Olivier Lang
The purpose of this systematic review was to provide a comprehensive analysis of the available clinical trials analyzing, in seniors, the effect of aerobic interval training (IAT) and continuous aerobic training (CAT) on peripheral Brain-derived neurotropic factor (BDNF) concentration. We identified 14 randomized or not-randomized intervention studies published up to January 2017 through a computer-assisted search (PUBMED, Pedro, and Science direct data bases). The 5 trials considering IAT and the 9 CAT totalized 988 individuals (age range: 58...
May 12, 2017: Rejuvenation Research
https://www.readbyqxmd.com/read/28498017/dietary-supplements-as-surrogate-of-mediterranean-diet-in-healthy-smoking-subjects
#11
Sonya Vasto, Giulia Accardi, Anna Aiello, Francesca Di Gaudio, Annalisa Barera, Serena Indelicato, Damiano Galimberti, Emilio Italiano, Roberto Monastero, Claudia Rizzo, Calogero Caruso, Giuseppina Candore
The interventions to slow ageing, favouring active life expectancy, represent the new perspectives in ageing investigation. Some mechanisms that delay or prevent the onset of ageing pathologies have been identified. Between them, a healthy lifestyle seems to reduce many risk factors. In particular, eating habits represent the most concrete, low cost way to act on ageing process. Mediterranean diet has received much attention since it has been consistently demonstrated its anti-oxidant and anti-inflammatory effects...
May 12, 2017: Rejuvenation Research
https://www.readbyqxmd.com/read/28351218/association-among-serum-insulin-like-growth-factor-1-frailty-muscle-mass-bone-mineral-density-and-physical-performance-among-community-dwelling-middle-aged-and-older-adults-in-taiwan
#12
Liang-Yu Chen, Yi-Hui Wu, Li-Kuo Liu, Wei-Ju Lee, An-Chun Hwang, Li-Ning Peng, Ming-Hsien Lin, Liang-Kung Chen
Aging is featured by the complex interrelationship among body composition, frailty status, and physical performance. The main aim of this study was to evaluate the association among serum insulin-like growth factor-1 (IGF-1), body composition, and physical function among community-dwelling middle-aged and elderly population in Taiwan. We conducted a cross-sectional study by using the data of I-Lan Longitudinal Aging Study, which recruited a total of 1833 community-dwelling people aged more than 50 years. Data of lean body mass (LBM), appendicular skeletal muscle mass (ASM), total fat mass (TFM), bone mineral density (BMD) of L-spine/hip, handgrip strength, walking speed, International Physical Activity Questionnaire (IPAQ), Charlson comorbidity index (CCI), serum levels of growth hormone, IGF-1, albumin, total cholesterol, triglyceride, blood urea nitrogen, and creatinine were retrieved for analysis...
May 9, 2017: Rejuvenation Research
https://www.readbyqxmd.com/read/28482748/robotic-and-sensor-technologies-for-mobility-in-older-people
#13
Lazaros Penteridis, Grazia D'Onofrio, Daniele Sancarlo, Francesco Giuliani, Francesco Ricciardi, Filippo Cavallo, Antonio Greco, Ilias Trochidis, Alexander Gkiokas
BACKGROUND: Maintaining independent mobility is fundamental to independent living and to the quality of life of older people. Robotic and sensor technologies may offer a lot of potential and can make a significant difference in the lives of older people and to their primary caregivers. AIM: To provide a presentation of the methods that are used up till now for analysis and evaluation of human mobility utilizing sensor technologies. To give the state of the art in robotic platforms for supporting the older people with mobility limitations...
May 8, 2017: Rejuvenation Research
https://www.readbyqxmd.com/read/28482746/neuromuscular-electrical-stimulation-combined-with-protein-ingestion-preserves-thigh-muscle-mass-but-not-muscle-function-in-healthy-older-adults-during-5-days-of-bed-rest
#14
Paul Reidy, Alec McKenzie, Preston Brunker, Daniel Nelson, Katherine Barrows, Mark Supiano, Paul LaStayo, Micah Drummond
Short-term bed rest in older adults is characterized by significant loss in leg lean mass and strength posing significant health consequences. The purpose of this study was to determine in healthy older adults if the daily combination of neuromuscular electrical stimulation and protein supplementation (NMES+PRO) would protect muscle mass and function after 5-days of bed rest. Twenty healthy older adults (~70y) were subjected to 5-days of continuous bed rest and were randomized into one of two groups: NMES+PRO (n=10) or CON (n=10)...
May 8, 2017: Rejuvenation Research
https://www.readbyqxmd.com/read/28482745/lifecourse-adversity-and-telomere-length-in-older-women-from-northeast-brazil
#15
Bruna Silva Oliveira, Maria Victoria Zunzunegui, Jacklyn Quinlan, Silvia Regina Batistuzzo de Medeiros, Ronaldo Luis Thomasini, Ricardo Oliveira Guerra
We examined associations between adverse childhood experiences (ACEs) and shorter telomere length (TL) in 83 older women, including 42 women with less than secondary education and 41 with secondary or more education in a city of Northeast Brazil, a region with substantial socioeconomic inequalities. The low education sample was selected from a representative survey at local neighborhood health centers, while the high education group consisted of a convenience sample recruited by advertising in community centers and centers affiliated with the local university...
May 8, 2017: Rejuvenation Research
https://www.readbyqxmd.com/read/28482740/effects-of-three-different-chair-based-exercise-programs-on-people-over-80-years-old
#16
José Cancela, Estrella Pallin, Ander Orbegozo, Carlos Ayán
This study aimed at comparing the effects of three chair-based exercise programs on people over 80 years. Thirty-six participants (87.91 ± 4.70 years) were randomly allocated to an elastic-band, pedal exerciser or range of motion exercise program. The participants exercised three days per week during three months. A hand-held dynamometer, the Tinetti Gait Balance, the Barthel Index and the Timed Up & Go tests (assessed by means of the Wiva® science sensor) were used to evaluate the effects of the programs on the participants strength, balance, functional independence and functional mobility, respectively...
May 8, 2017: Rejuvenation Research
https://www.readbyqxmd.com/read/28478705/rejuvenation-of-cardiac-tissue-developed-from-reprogrammed-aged-somatic-cells
#17
Zhao Cheng, Hong-Ling Peng, Rong Zhang, Xian-Ming Fu, Guang-Sen Zhang
Induced pluripotent stem cells (iPSCs) derived through somatic cell reprogramming have been reported to reset aged somatic cells to a more youthful state, characterized by elongated telomeres, a rearranged mitochondrial network, reduced oxidative stress and restored pluripotency. However, it is still unclear whether the reprogrammed aged somatic cells can function normally as embryonic stem cells (ESCs) during development and be rejuvenated. In the current study, we applied the aggregation technique to investigate whether iPSCs derived from aged somatic cells could develop normally and be rejuvenated...
May 6, 2017: Rejuvenation Research
https://www.readbyqxmd.com/read/28437187/synergy-between-choroid-plexus-epithelial-cell-conditioned-medium-and-knockout-serum-replacement-converts-human-adipose-derived-stem-cells-to-dopamine-secreting-neurons
#18
Mahdi Eskandarian Boroujeni, Mossa Gardaneh, Mehrnoosh Hasan Shahriari, Abbas Aliaghaei, Sanaz Hasani
Human adipose-derived stem cells (hADSCs) have great capacity to differentiate into mesodermal origins as well as nonmesodermal lineages, including neural cells. This valuable feature paves the way for the therapeutic application of hADSCs for neurodegenerative maladies such as Parkinson's disease (PD). We tested the capacity of choroid plexus epithelial cell-conditioned medium (CPEC-CM) alone or cocktailed with knockout serum (KS) to induce dopaminergic (DAergic) differentiation of hADSCs. To this end, hADSCs from lipoaspirate were phenotypically characterized and shown to maintain mesodermal multipotency so that selected media easily differentiated them into osteoblasts, chondrocytes, and adipocytes...
April 27, 2017: Rejuvenation Research
https://www.readbyqxmd.com/read/28281877/comprehensive-analysis-of-interaction-networks-of-telomerase-reverse-transcriptase-with-multiple-bioinformatic-approaches-deep-mining-the-potential-functions-of-telomere-and-telomerase
#19
Chunyu Hou, Fei Wang, Xuewen Liu, Guangming Chang, Feng Wang, Xin Geng
Telomerase reverse transcriptase (TERT) is the protein component of telomerase complex. Evidence has accumulated showing that the nontelomeric functions of TERT are independent of telomere elongation. However, the mechanisms governing the interaction between TERT and its target genes are not revealed clear. The biological functions of TERT are not fully elucidated and have thus far been underestimated. To further explore these functions, we investigated TERT interaction networks using multiple bioinformatic databases, including BioGRID, STRING, DAVID, GeneCards, GeneMANIA, PANTHER, miRWalk, mirTarBase, miRNet, miRDB, and TargetScan...
April 21, 2017: Rejuvenation Research
https://www.readbyqxmd.com/read/28384033/young-blood-plasma-administration-to-fight-alzheimer-s-disease
#20
Giorgio Aicardi
Despite decades of intensive research, no drugs can cure or even stabilize Alzheimer's disease (AD). Current pharmacological treatments only partially mask the symptoms while the disease progresses within the brain. Finding a preventive measure or a cure for people with AD is indeed a worldwide urgent priority. A recent interesting study by T. Wyss-Coray's research group provides the first evidence that exposure to young blood or plasma can reverse some AD-related molecular and behavioral alterations. Heterochronic parabiosis (shared blood circulation) of AD transgenic mice with young healthy mice did not reduce amyloidosis and microglial activation in AD mice, but reversed the loss of synaptophysin and calbindin (critical synaptic proteins, indicators of cognitive decline in AD) in the dentate gyrus, and the abnormal expression, in the hippocampus, of many genes involved in key neuronal signaling pathways...
April 6, 2017: Rejuvenation Research
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