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Rejuvenation Research

Fang Dou, YueTong Liu, Limin Liu, Jingwen Wang, Ting Sun, Fei Mu, Qiyan Guo, Chao Guo, Na Jia, Wenxing Liu, Yi Ding, Aidong Wen
Fibrosis is the major pathological feature of chronic kidney disease (CKD). Aloe-emodin (AE), one of the main active compound in Rhubarb, is widely used for renal protection. However, mechanisms implied in the kidney fibrosis modulation after AE treatment for CKD remain elusive. Here, we explored protective effects of AE for renal fibrosis and the involved mechanisms in vivo and in vitro. The renal fibrosis mice model was established via Unilateral ureteral obstruction (UUO). We found that AE administration significantly ameliorated UUO-induced impairment of renal, evidenced by improved the histopathological abnormalities, the body weight and abnormal renal function in mice model...
September 14, 2018: Rejuvenation Research
Peter Joerg Rohdewald
Extension of the healthy life span is of primary importance for the aging society. Among exercise, healthy nutrition and mental training, food supplements are widely used as preventive measures to postpone the diverse symptoms of aging. The extract from the bark of the French maritime pine, Pycnogenol, rich on flavonoids, has anti-inflammatory and anti-oxidative activity, proven in in-vivo studies. The extract reduces oxidative stress and improves endothelial health. Its anti-thrombotic properties are based on inhibition of platelet aggregation...
September 14, 2018: Rejuvenation Research
Chun-Feng Liu, Xiao-Lin Li, Zi-Long Zhang, Lu Qiu, Shi-Xuan Ding, Jun-Xin Xue, Guo-Ping Zhao, Jian Li
Although the health benefits attributed to urolithin A, such as anti-cancer, anti-inflammatory, and antioxidant effects, are based on numerous, diverse studies carried out in vitro, the biological effects of urolith A are still not entirely understood. In this study, we explored the biological effects of urolithin A using senescent human skin fibroblasts to determine whether urolithin A has any anti-aging potential. Our results showed that urolithin A significantly increased type I collagen expression, and reduced matrix metalloproteinase-1(MMP-1) expression...
September 14, 2018: Rejuvenation Research
Samuel L Buckner, Scott Dankel, Zachary W Bell, Takashi Abe, Jeremy Loenneke
The relationship between grip strength and mortality is often used to underscore the importance of resistance exercise in physical activity guidelines. However, grip strength does not appear to appreciably change following traditional resistance training. Thus, grip strength could be considered reflective of strength independent of resistance exercise. If true, grip strength is not necessarily informing us of the importance of resistance exercise as an adult, but potentially highlighting inherent differences between individuals who are stronger at "baseline" compared to their weaker counterpart...
September 10, 2018: Rejuvenation Research
Sha Zhang, Jie Li, Pei Xie, Ting Zang, Haibin Shen, Guochun Cao, Ying Zhu, Zhenggang Yue, Zhe Li
Chronic inflammation is a major driving factor for the development of colitis-associated cancer (CAC). It is extensively acknowledged that patients who have long-standing inflammation bowel disease are at high risk for developing CAC. However, the metabolic alteration by which chronic intestinal inflammation promotes colorectal cancer is unclear. In the present study, we constructed dextran sulfate sodium (DSS)-induced colitis mouse model to uncover possible alterations in the metabolism indexes. Interestingly, after DSS diet administration, the expression of metabolism indexes and c-Myc increased...
September 4, 2018: Rejuvenation Research
Kuldeep Nigam, Atinderpal Kaur, Kailash Manda, Amit Tyagi, Reema Gabrani, Shweta Dang
In the present work, PLGA nanoparticles of baclofen (Bcf-PLGA-NPs) were developed and optimized using nanoprecipitation method. The average particle size of the Bcf-PLGA-NP was found to be 124.8 nm, polydispersity index of 0.225 and zeta potential was found to be in the range of -20.4 mV. In-Vitro dissolution studies showed that baclofen was released from PLGA NPs in a sustained fashion from 50 % release in 2.5 hrs to 80-85% in 24 hrs. MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) assay on Neuro-2a neuroblastoma cell line showed comparably low cytotoxicity of Bcf-PLGA-NPs as compared to aqueous solution of Baclofen at reported Cmax values of the drug 737...
September 3, 2018: Rejuvenation Research
Bo Zhang, Yan Li, Jia-Wei Liu, Xue-Wei Liu, Wei Wen, Yu Cui, Shu-Ming Huang
Kaixin-San (KXS), a Chinese formula, was used to treat "amnesia," a senile dementia in the modern world. This formula was reported to improve behavioral performances in many animal models. This study was designed to explore how KXS has improved amyloid-β (Aβ)-induced memory dysfunction in mice. The mouse models were achieved through unilateral ventricle injection with Aβ42 . The effects of KXS on memory improvement were evaluated by the step-down test. The electrophysiological changes induced by KXS were measured by long-term potentiation (LTP) analysis in the hippocampus in vivo...
August 29, 2018: Rejuvenation Research
Alison Carter, Edward Meinert, David Brindley
Based on experience and the existing limited research literature in biotechnology corporate governance, the authors propose potential attributes of minimum corporate governance standards for biotechnology companies, as a basis for further quantitative and qualitative research. The authors assert that the recent proliferation of biotechnology start-up organisations is substantively changing inter- and intra-organizational cultures throughout the healthcare sector via a 'cascade of governance'. Therefore, governance decisions and actions - both positive and negative - that are instituted in start-up biotech companies may set new norms for other start-up biotech companies, the larger (bio)pharmaceutical companies by which they are acquired and the range of healthcare sub-sector actors that interact with biotechnology companies...
August 24, 2018: Rejuvenation Research
Ginus Partadiredja, Nisa Karima, Kurnia Putri Utami, Denny Agustiningsih, Zaenal Muttaqien Sofro
Aging causes the degeneration of organs of the locomotor system, including the cerebellum and bones. Exercise may reverse this deterioration. d-galactose has been frequently used in rodents to accelerate aging. The present study aimed at investigating the effects of exercise on cerebellar and serum growth factors, motor activity, and the number of bone cells of the femoral head of d-galactose-treated rats. Twenty-four male Wistar rats were divided randomly into four groups, that is, three treated groups injected with 300 mg/(mL·kg) body weight (bw) d-galactose solution daily for 4 weeks, and a control group injected with normal saline...
August 23, 2018: Rejuvenation Research
Yuki Hayashi, Rei Kawamura, Shin-Ichiro Nishimatsu, Osamu Fukuta, Misako Nakashima
OBJECTIVE: Pulp regeneration by stem cell transplantation declines due to age-related reduction. We hypothesized that administration of a cytokine together with the cell transplantation may improve the stem cell niche microenvironment and promote regeneration. CCL11 is implicated as a factor in aging. This investigation was performed to investigate the changes in the quality of the regenerated pulp by administration of CCL11 antibody in the aged mice and elucidate the underlying mechanisms...
August 23, 2018: Rejuvenation Research
Abhishek Kumar Singh, Sandeep Singh, Vinay Kumar Tripathi, Akalabya Bissoyi, Geetika Garg, Syed Ibrahim Rizvi
Brain aging is an intricate and natural phenomenon exclusively characterized by oxidative stress, accumulation of oxidatively damaged macromolecules, and alterations in structure and function of neurons that further increase the risk factor for most of the neurodegenerative diseases. In addition, age-dependent defective autophagy has also been implicated to favor the pathogenesis and prevalence of the neurological diseases. Therefore, the development of strategies that delay aging and the concomitant neurological disorders remain elusive...
August 23, 2018: Rejuvenation Research
Roberta Castilhos Detanico Bohrer, Gleber Pereira, Joice Katiane Beck, Angélica Lodovico, André Luiz Felix Rodacki
The purpose of this study was to investigate the effects of multicomponent training program, designed to improve the torque around the ankle joint performing high-speed movement execution, on healthy older adults. Participants were balanced by torque around the ankle joint and randomly allocated to either exercise (n = 12, 69.7 ± 4.8 years, 74.6 ± 16.8 kg, 1.63 ± 0.10 m) or control group (CG) (n = 14, 70.86 ± 6.48 years; 73.5 ± 13.4 kg, 1.56 ± 0.05 m). The exercise group (EG) performed a multicomponent training of resistance, agility, and coordination exercises, focusing on the plantar flexor muscles during 12 weeks (3 days per week)...
August 23, 2018: Rejuvenation Research
Donatella Poz, Elena De Falco, Calogera Pisano, Rossella Madonna, Peter Ferdinandy, Carmela Rita Balistreri
Evidence suggests association of red blood cell distribution width (RDW) with cardiovascular diseases (CVDs). On the contrary, we underline that the sole RDW values cannot represent a valid CVD biomarker. High RDW values are expression of biological effects of a lot of both endogenous and exogenous factors (i.e. age, sex, genetic background, inflammation, hormones, drugs, diet, exercise, haematological analyzers, and ranges of values), modulating the biology and physiology of erythrocytes. Thus, the singular monitoring of RDW cannot be used to predict cardiovascular disorders...
August 22, 2018: Rejuvenation Research
Olalla Bello, Gonzalo Marquez, Miguel Fernandez-Del-Olmo
Treadmills are often used as rehabilitation devices to improve gait in Parkinson's disease (PD). Kinematic differences between treadmill and overground gait have been reported. However, electromyographic (EMG) patterns during treadmill and overground walking have not been systematically compared. The aim of this study was to assess the effects of treadmill gait on the magnitude of the EMG activity of the lower limb muscles in PD. We measured EMG activity of the tibialis anterior, gastrocnemius medialis, vastus lateralis, and biceps femoris of nine individuals with PD and nine healthy matched controls...
August 21, 2018: Rejuvenation Research
Colin Farrelly
In this article I argue that senescence (biological aging) is one of the greatest threats to human freedom in the 21st century. The two most prominent conceptions of freedom are "negative" and "positive" liberty (Berlin 1969). The negative conception of liberty equates freedom with the absence of interference, whereas the positive conception equates freedom with having the capacity to be self-determining. By critically examining both the negative and positive conceptions of liberty, I make the case that senescence does violate our liberty, on both accounts of freedom...
August 19, 2018: Rejuvenation Research
James Clement, Matthew Wong, Anne Poljak, Perminder Sachdev, Nady Braidy
Nicotinamide adenine dinucleotide (NAD+) is an essential pyridine nucleotide that serves as an electron carrier in cellular metabolism and plays a crucial role in the maintenance of balanced redox homeostasis. Quantification of NAD+:NADH and NADP+:NADPH ratios are pivotal to a wide variety of cellular processes, including intracellular secondary messenger signalling by CD38 glycohydrolases, DNA repair by poly(adenosine diphosphate ribose) polymerase (PARP), epigenetic regulation of gene expression by NAD-dependent histone deacetylase enzymes known as sirtuins, and regulation of the oxidative pentose phosphate pathway...
August 19, 2018: Rejuvenation Research
David Brindley, Edward Meinert, Alison Carter
Data and Corporate Governance in Pharma and Digital Health: A Necessary Regulatory Convergence.
August 9, 2018: Rejuvenation Research
Kiana Rafiepour, Ali Salehzadeh, Vahid Sheibani, Saeed Esmaeili-Mahani
Parkinson's disease (PD) is a destroying and prevalent neurodegenerative disease which is characterized by a progressive death of midbrain dopaminergic neurons. It is important to understand the possible neuroprotective effects of reagents that rescue the neurons from death and apoptosis. Here, we investigated the effects of abscisic acid (ABA) on 6-OHDA-induced neurotoxicity in human dopaminergic neuroblastoma SH-SY5Y cell line as an in vitro model of PD. Cell damage was induced by 150 μM 6-OHDA and the cells viability was examined by MTT assay...
August 9, 2018: Rejuvenation Research
Brian P Hanley, William Bains, George Church
We examine self-experimentation ethics history and practice, related law, use scenarios in universities and industry, and attitudes. We show through analysis of the historical development of medical ethics and regulation, from Hippocrates through Good Clinical Practice that there are no ethical barriers to self-experimentation. When the self-experimenter is a true investigator, there is no other party to be protected from unethical behavior. We discuss the n-of-1 issue in self-experiments, and make suggestions for improving experiment design...
August 8, 2018: Rejuvenation Research
Michele Pascali, Davide Quarato, Francesco Carinci
The ideal perioral and lip rejuvenation technique provides the longest period of efficacy, lowest complication rate, and best esthetic results. Genetics, intrinsic aging, sun exposure, and repetitive muscle twitching of the orbicularis oris produce angular, radial, and vertical lines of the perioral lines and, for this reason, the needs of patients in the treatment of this anatomical area can range from simple lip enhancement to a broader and more comprehensive treatment with simultaneous correction of perioral wrinkles...
August 8, 2018: Rejuvenation Research
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