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Rejuvenation Research

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https://www.readbyqxmd.com/read/29137544/effect-of-aerobic-training-on-peak-oxygen-uptake-among-seniors-aged-70-or-over-a-meta-analysis-of-randomized-controlled-trials
#1
Walid Bouaziz, Lukshe Kanagaratnam, Thomas Vogel, Elise Schmitt, Moustapha Dramé, Georges Kaltenbach, Bernard Geny, Pierre Olivier Lang
Older adults undergo a progressive decline in cardiorespiratory fitness and functional capacity. This lower peak oxygen uptake (VO2peak) level is associated with increased risk of frailty, dependency, loss of autonomy, and mortality from all causes. Regular physical activity and particularly aerobic training (AT) has been shown to contribute to better and healthy ageing. We conducted a meta-analysis in order to measure the exact benefit of AT on VO2peak in seniors aged 70 years or over. A comprehensive, systematic database search for manuscripts was performed in Embase, Medline, PubMed Central, ScienceDirect, Scopus, and Web of Science using key words...
November 14, 2017: Rejuvenation Research
https://www.readbyqxmd.com/read/29125070/circulating-mitochondrial-dna-at-the-crossroads-of-mitochondrial-dysfunction-and-inflammation-during-aging-and-muscle-wasting-disorders
#2
Anna Picca, Angela Maria Serena Lezza, Christiaan Leeuwenburgh, Vito Pesce, Riccardo Calvani, Maurizio Bossola, Ester Manes-Gravina, Francesco Landi, Roberto Bernabei, Emanuele Marzetti
Mitochondrial structural and functional integrity is maintained through the coordination of several processes (e.g., biogenesis, dynamics, mitophagy), collectively referred to as mitochondrial quality control. Dysfunctional mitochondrial quality control and inflammation are hallmarks of aging and are involved in the pathogenesis of muscle wasting disorders, including sarcopenia and cachexia. One of the consequences of failing mitochondrial quality control is the release of mitochondria-derived damage-associated molecular patterns...
November 10, 2017: Rejuvenation Research
https://www.readbyqxmd.com/read/29125039/astrocyte-autophagy-flux-protects-neurons-against-oxygen-glucose-deprivation-and-ischemic-reperfusion-injury
#3
Xue Liu, Fengfeng Tian, Shiquan Wang, Feng Wang, Lize Xiong
The role of autophagy varies with the type of acute brain injury. In general, autophagy mediates a clear neuroprotective effect in intoxication caused by various psychoactive agents, subarachnoid hemorrhage and spinal cord injury. In contrast, autophagic cell death has also been reported to actively contribute to neuronal loss in neonatal hypoxic ischemic encephalopathy. However, it still remains to be determined whether autophagy pays a cytoprotective or a cytotoxic role in stroke. Previous studies focused primarily on the role of neurons rather than the role of astrocytes in brain injury...
November 10, 2017: Rejuvenation Research
https://www.readbyqxmd.com/read/28548620/baicalein-exerts-beneficial-effects-in-d-galactose-induced-aging-rats-through-attenuation-of-inflammation-and-metabolic-dysfunction
#4
Dan-Dan Duan, Ke-Xin Wang, Yu-Zhi Zhou, Xue-Mei Qin, Li Gao, Guan-Hua Du
Baicalein is a flavonoid isolated from the roots of Scutellaria baicalensis Georgi. This study aimed to ascertain the effects and potential underlying mechanisms of baicalein in d-galactose (d-gal)-induced aging rat model by integration of behavior examination, biochemical detection, and (1)H nuclear magnetic resonance (NMR)-based metabolomic approach. Our findings suggest that baicalein significantly attenuated memory decline in d-gal-induced aging model, as manifested by increasing recognition index in novel object recognition test, shortening latency time, and increasing platform crossings in Morris water maze test...
November 8, 2017: Rejuvenation Research
https://www.readbyqxmd.com/read/29048250/inhibition-of-abeta-proteotoxicity-by-paeoniflorin-in-i-caenorhabditis-elegans-i-through-regulation-of-oxidative-and-heat-shock-stress-responses
#5
Liping Ai, Fan Yang, Jie Song, Yan Chen, Lingyun Xiao, Qiangqiang Wang, Liangyi Wang, Haifeng Li, Tao Lei, Zebo Huang
Alzheimer's disease (AD) is a common form of dementia and amyloid-β peptide (Aβ) aggregation is considered to be one of its main causes. Paeoniflorin has been previously shown to attenuate cognitive damage inflicted by exogenous Aβ protein. Using transgenic <i>Caenorhabditis elegans</i> models expressing human Aβ1-42, we demonstrate here that paeoniflorin can delay progressive paralysis caused by endogenous Aβ expression and reduce the amount of toxic Aβ oligomers in vivo although it has no effect on Aβ aggregation <i>in vitro</i>...
October 19, 2017: Rejuvenation Research
https://www.readbyqxmd.com/read/28994636/meetings-calendar-2017
#6
(no author information available yet)
No abstract text is available yet for this article.
October 10, 2017: Rejuvenation Research
https://www.readbyqxmd.com/read/28851251/targeting-aging-with-functional-food-pasta-with-opuntia-single-arm-pilot-study
#7
Anna Aiello, Danilo Di Bona, Giuseppina Candore, Ciriaco Carru, Angelo Zinellu, Giuseppe Di Miceli, Aldo Nicosia, Caterina Maria Gambino, Paolo Ruisi, Calogero Caruso, Sonya Vasto, Giulia Accardi
Interventions to extend life span represent the new perspective in aging investigation. Healthy dietary habits are important modifiable factors that can favor a healthy aging phenotype. Many studies have demonstrated benefits for metabolic syndrome and type 2 diabetes mellitus resulting from the traditional Mediterranean foods. Opuntia Ficus Indica (OFI), widespread in the Mediterranean basin, belongs to the Cactaceae family. It is known for its antioxidant and anti-inflammatory properties. Moreover, products containing extracts from OFI fruits or cladodes have been used to control obesity and other metabolic parameters, such as glycemia and lipid profile...
October 10, 2017: Rejuvenation Research
https://www.readbyqxmd.com/read/28982278/use-of-medaka-fish-as-vertebrate-model-to-study-the-effect-of-cocoa-polyphenols-in-the-resistance-to-oxidative-stress-and-lifespan-extension
#8
Ana Virginia Sánchez-Sánchez, Aránzazu Leal-Tassias, Neus Rodríguez-Sánchez, Marina Piquer-Gil, Patricia Martorell, Salvador Genovés, Carlos Acosta, Deborah Burks, Daniel Ramón, José Luis Mullor
Oxidative stress can induce cell apoptosis and thus, plays an important role in aging. Antioxidant foods protect tissues from oxidative stress and contribute to a healthier life style. Here we described the used of medaka embryos (Oryzias latipes) to study the putative antioxidant capacity of dietary cocoa extract in vertebrates. A polyphenol-enriched cocoa extract regulated the expression of several genes implicated in oxidative stress, thereby protecting fish embryos from induced oxidative stress. The cocoa extract activated SOD enzyme activity in embryos and in adult fish tissues, suggesting a common mechanism for protection during embryonic development and adulthood...
October 6, 2017: Rejuvenation Research
https://www.readbyqxmd.com/read/28712336/clinical-and-histological-studies-of-suborbital-wrinkles-treated-with-fractional-bipolar-radiofrequency
#9
Jun Huang, Wenyou Yu, Zhen Zhang, Xiangdong Chen, Ewelina Biskup
Fractional bipolar radiofrequency (FRF) has been well established for facial rejuvenation, but there is no report showing its efficacy for the treatment of suborbital wrinkles. The aim of this study was to investigate and objectively evaluate the clinical efficacy and side effects of FRF for the treatment of suborbital wrinkles, including observation of histological changes of the suborbital skin along the therapy. Thirty-two female patients with suborbital wrinkles underwent three sessions of FRF at 3-week intervals with a follow-up period of 6 months after treatment...
September 27, 2017: Rejuvenation Research
https://www.readbyqxmd.com/read/28791889/symbiotic-origin-of-aging
#10
Edward F Greenberg, Sergei Vatolin
Normally aging cells are characterized by an unbalanced mitochondrial dynamic skewed toward punctate mitochondria. Genetic and pharmacological manipulation of mitochondrial fission/fusion cycles can contribute to both accelerated and decelerated cellular or organismal aging. In this work, we connect these experimental data with the symbiotic theory of mitochondrial origin to generate new insight into the evolutionary origin of aging. Mitochondria originated from autotrophic α-proteobacteria during an ancient endosymbiotic event early in eukaryote evolution...
September 25, 2017: Rejuvenation Research
https://www.readbyqxmd.com/read/28782427/berberine-improves-diabetic-encephalopathy-through-the-sirt1-er-stress-pathway-in-db-db-mice
#11
Hong-Ying Li, Xin-Chen Wang, Yu-Min Xu, Na-Chuan Luo, Si Luo, Xu-Yi Hao, Shu-Yi Cheng, Jian-Song Fang, Qi Wang, Shi-Jie Zhang, Yun-Bo Chen
The association between diabetes and dementia has been well demonstrated by epidemiologic studies. Berberine (BBR) has been reported to ameliorate diabetes and diabetic encephalopathy (DE). However, the mechanism is still unknown. In this study, we employ a diabetic model, db/db mice, to explore whether BBR could protect DE through the SIRT1/endoplasmic reticulum (ER) stress pathway. Behavioral results (Morris water maze, Y-maze spontaneous alternation test, and fear conditioning test) showed that oral administration of BBR (50 mg/kg) improved the learning and memory ability...
September 21, 2017: Rejuvenation Research
https://www.readbyqxmd.com/read/28712331/feasibility-and-efficacy-of-mat-pilates-on-people-with-mild-to-moderate-parkinson-s-disease-a-preliminary-study
#12
Jose Maria Cancela, Irimia Mollinedo-Cardalda, Carlos Ayán, Iris Machado de Oliveira
This pilot study aimed at assessing the feasibility and efficacy of a Mat Pilates program in people with mild-to-moderate Parkinson's disease (PD). The participants carried out a Mat Pilates program twice a week for 12 weeks. The Senior Fitness Test battery and the 39-item PD Questionnaire were used to assess the effects of the program on the participants' fitness level and quality of life. A total of 16 patients with mild-to-moderate PD volunteered for and finished the study. The Mat Pilates program proved to be feasible...
September 14, 2017: Rejuvenation Research
https://www.readbyqxmd.com/read/28895468/prevalence-of-ideal-cardiovascular-health-and-its-association-with-cognitive-function-in-older-adults-the-chilean-national-health-survey-2009-2010
#13
Antonio García-Hermoso, Robison Ramírez-Vélez, Rodrigo Ramirez-Campillo, Mikel Izquierdo
BACKGROUND: Health behaviors and risk factors are independently related with cognitive function in older adults. This study aimed to examine the prevalence and relationship between cognitive function and a number of ideal cardiovascular health metrics in older adults from the 2009-2010 Chilean National Health Survey. BASIC PROCEDURES: Data from 460 older adults (mean age 73.5 years old, 59.3% women) from the 2009-2010 Chilean Health Survey were analyzed. Ideal cardiovascular health was defined as meeting the ideal levels of the following components: four behaviors (smoking, body mass index, physical activity and diet adherence) and three factors (total cholesterol, blood pressure and fasting glucose)...
September 12, 2017: Rejuvenation Research
https://www.readbyqxmd.com/read/28891399/response-of-human-fetal-liver-progenitor-cell-types-to-temperature-and-ph-stresses-in-vitro
#14
Eva Schmelzer, Hubert G Foka, Robert L Thompson, Angelo Luca, Bruno Gridelli, Jörg C Gerlach
Prolonged physiological stresses including abnormal pH and temperature are deleterious. Yet, human hepatic progenitors have been shown to be quite tolerant of temporary temperature stress such as in cold ischemia. We aimed to identify how various stresses affect liver progenitors, and to determine whether distinct effects exist on different progenitor cells of the human liver. Total fetal liver cells were exposed to low (25°C), normal (37°C), or high (40°C) temperatures, or low (6.76), normal (7.35), or high (7...
September 11, 2017: Rejuvenation Research
https://www.readbyqxmd.com/read/28891383/a-hypothesis-moderate-consumption-of-alcoholic-beverages-contributes-to-lower-prevalence-of-type-2-diabetes-t2dm-due-to-scavenging-of-%C3%AE-dicarbonyls-by-several-classes-of-dietary-phytochemicals
#15
Benjamin S Szwergold
The world is experiencing an epidemic of Type-2-Diabetes (T2DM). This has led to increased morbidity and mortality, explosive growth in heath-care budgets and has an even greater, if indirect, impact on societies and economies of the affected countries. While genetic susceptibility to T2DM is a major determinant of its prevalence, changes in life-styles also play a role. One such change has been a transition from traditional diets characterized by low caloric and high nutrient density to calorie-rich but nutrient-poor Western diets...
September 11, 2017: Rejuvenation Research
https://www.readbyqxmd.com/read/28885889/a-genetic-variant-of-asct2-hampers-in-vitro-rna-splicing-and-correlates-with-human-longevity
#16
Patrizia D'Aquila, Paolina Crocco, Francesco De Rango, Cesare Indiveri, Dina Bellizzi, Giuseppina Rose, Giuseppe Passarino
Given the role of amino acid regulation for physiological and pathological cell proliferation, we investigated whether the variability of solute carrier family 1, member 5 (SLC1A5, namely ASCT2), encoding for ASCT2 protein, a major glutamine transporter, is related to longevity. A total of 607 differently aged unrelated individuals, 351 very old subjects (≥85 years, range 85-106 years, mean age 93.82 ± 4.44 years) and 256 younger controls (<85 years, range 64-84 years, mean age 73.60 ± 5.70 years) were analyzed...
September 8, 2017: Rejuvenation Research
https://www.readbyqxmd.com/read/28673122/rejuvenating-effect-of-long-term-insulin-like-growth-factor-i-gene-therapy-in-the-hypothalamus-of-aged-rats-with-dopaminergic-dysfunction
#17
José I Schwerdt, Micaela Lopez-Leon, Gloria M Cónsole, Oscar A Brown, Gustavo R Morel, Eduardo Spinedi, Rodolfo G Goya
The aging female rat constitutes an interesting model of spontaneous and progressive age-related dopaminergic dysfunction as it allows assessing new therapeutic strategies for Parkinson's disease. Insulin-like growth factor I (IGF-I) is emerging as a powerful neuroprotective molecule, strongly induced in the central nervous system after different insults. We constructed a helper-dependent recombinant adenoviral vector (HDRAd-IGFI) harboring the gene for rat IGF-I. This was used to implement long-term IGF-I gene therapy in the hypothalamus of aged female rats, which display hypothalamic dopaminergic (DA) dysfunction and, as a consequence, chronic hyperprolactinemia...
September 6, 2017: Rejuvenation Research
https://www.readbyqxmd.com/read/28728538/effects-of-cataract-opacity-and-surgery-on-sleep-quality
#18
Aya Kokune-Takahashi, Masahiko Ayaki, Kazuo Tsubota, Kazuno Negishi
This study aimed to identify the type of cataract opacity associated with subjective sleep quality for cataract patients. A total of 180 consecutive patients (average age 74.2 years) underwent cataract surgery with implantation of an ultraviolet-blocking or blue light-blocking intraocular lens. The participants' subjective sleep quality was evaluated using the Pittsburgh sleep quality index (PSQI) before and at 2 months after surgery. Patients were divided into two groups for analysis: normal sleepers (preoperative PSQI ≤5) and poor sleepers (preoperative PSQI ≥6)...
August 29, 2017: Rejuvenation Research
https://www.readbyqxmd.com/read/28661208/natural-substances-for-prevention-of-skin-photoaging-screening-systems-in-the-development-of-sunscreen-and-rejuvenation-cosmetics
#19
Vladimir Kostyuk, Alla Potapovich, Ahmed R Albuhaydar, Wolfgang Mayer, Chiara De Luca, Liudmila Korkina
Solar broadband UV irradiation is commonly regarded as a major causative reason for cutaneous photoaging. The pro-aging molecular pathways and cellular targets affected by UVA+UVB light in human skin have been extensively investigated. Notwithstanding growing knowledge in mechanisms of photoaging, research and development of clinically efficient, nontoxic, and sustainable topical preparations providing full physical, chemical, and biological photoprotection still remain a great challenge for pharmaceutical and cosmetic industries...
August 28, 2017: Rejuvenation Research
https://www.readbyqxmd.com/read/28661207/thyroid-function-in-aging-a-discerning-approach
#20
Leonidas H Duntas
Thyroid disease, increasingly common among the general population, is also rising among the elderly, which, given that the global population is aging, constitutes a serious public health issue that needs to be urgently addressed. The most common thyroid disease in younger and older individuals alike is hypothyroidism, including subclinical (SCH) and overt disease. Since TSH tends to increase with age due to intrinsic changes of thyroid metabolism and the gradual resetting of the hypothalamic-pituitary-thyroid axis, the diagnosis of "true" hypothyroidism is challenging, another difficulty being distinguishing disease-specific from aging-associated clinical symptoms...
August 28, 2017: Rejuvenation Research
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