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Rejuvenation Research

Benjamin Zealley, Aubrey D N J de Grey
January 19, 2017: Rejuvenation Research
Aubrey D N J de Grey
January 19, 2017: Rejuvenation Research
Elena Marín-Cascales, Pedro E Alcaraz, Jacobo A Rubio-Arias
The purposes of this study were to analyze the impact of 24 weeks of vibratory and multicomponent training (MT) and to determine what type of training creates greater adaptations on body composition and isokinetic strength of the knee and ankle joints in postmenopausal women. Thirty-eight women (60.0 ± 6.3 years) were randomly assigned to whole body vibration group (WBVG), multicomponent training group (MTG), or a control group. A significant decrease in total fat mass was observed in experimental groups...
January 19, 2017: Rejuvenation Research
Fei Mu, Jialin Duan, Haixu Bian, Xiaohu Zhai, Peijin Shang, Rui Lin, Meina Zhao, Dongmei Hu, Ying Yin, Aidong Wen, Miaomiao Xi
Extract of Salvia miltiorrhiza and Dalbergia Odorifera (SM-DOO) has been traditionally used for the prevention and treatment of cardiovascular diseases. However, information regarding the pharmacodyamic material basis and potential mechanism remain unknown. Male Sprague-Dawley rats were divided into four groups: Sham, Model, Diltiazem and SM-DOO group, n=6. Rats were pretreated with homologous drugs for 7 days, then subjected to 30 min of ischemia followed by 180 min of reperfusion. Cardioprotection effects of SM-DOO on myocardial ischemia/reperfusion (MI/R) injury rats were examined by hemodynamic, infarct area, histopathology, biochemical indicators and western blot analysis...
January 16, 2017: Rejuvenation Research
Geetika Garg, Sandeep Singh, Abhishek Kumar Singh, Syed Ibrahim Rizvi
Metformin, a biguanide, is a widely used antidiabetic drug, which inhibits gluconeogenesis and is used to treat hyperglycemia in type 2 diabetes. Through activation of AMPK (AMP-activated protein kinase) pathway, metformin also mimics caloric restriction health benefits. Aging causes substantial molecular to morphological changes in brain, the brain cells being more susceptible toward oxidative stress mediated damages due to the presence of high lipid content and higher oxygen consumption. Wistar rats (naturally aged and d-galactose induced rat model) were supplemented with metformin (300 mg/kg b...
January 9, 2017: Rejuvenation Research
Marion Coquand-Gandit, Marie Paule Jacob, Wassim Fhayli, Beatriz Romero Ruiz de la Hermosa, Miglena Georgieva, Stéphanie Bouillot, Eric Estève, Jean-Pierre Andrieu, Sandrine Brasseur, Sophie Bouyon, Natalio Garcia-Honduvilla, Philippe Huber, Julia Bujan, Milena Atanasova, Gilles Faury
Normal arterial aging processes involve vascular cell dysfunction associated with wall stiffening, the latter being due to progressive elastin and elastic fiber degradation, as well as elastin and collagen cross-linking by advanced glycation end-products (AGE). These processes progressively lead to cardiovascular dysfunction during aging. Elastin is only synthesized during late gestation and childhood, and further degradation occurring throughout adulthood cannot be physiologically compensated by replacement of altered material...
January 5, 2017: Rejuvenation Research
Zhizhun Mo, Yuhong Liu, Cailan Li, Lieqiang Xu, Lingling Wen, Yanfang Xian, Zhixiu Lin, Janis Ya-Xian Zhan, Jiannan Chen, Fangfang Xu, Zi-Ren Su
This study was designed to explore how supercritical fluid CO2 extract of Ligusticum chuanxiong Hort (CX) protect mouse liver and kidney from D-galactose induced injury. The antioxidant capacity of CX was confirmed both in vitro and in vivo. The D-galactose induced malondialdehyde increasing was attenuated by CX, as well as the increases of aspartate aminotransferase, alanine aminotransferase, blood urea nitrogen and creatinine level. In addition, the activities of antioxidant enzymes were markedly renewed, and the genes expressions of these enzymes were up-regulated in CX groups...
January 5, 2017: Rejuvenation Research
Xin Liu, Jinghui Lei, Ke Wang, Lu Ma, Dan Liu, Yunhui Du, Ye Wu, Suli Zhang, Wen Wang, Xin L Ma, Huirong Liu
Mitochondrial homeostasis is a key process involved in cellular destiny and organic function. When mitochondrial status is abnormal, it will become a "death motor". Impaired mitochondria lead to the release of cytochrome c, and then trigger mitochondria-induced caspase activation. Omi/HtrA2, a serine protease, locates in mitochondria, and involves in mitochondrial homeostasis. Increased Omi/HtrA2 is observed in aging cardiac tissues, and whether this has effects on mitochondrial status hasn't been reported...
December 21, 2016: Rejuvenation Research
Veronica Palomera-Avalos, Christian Griñan-Ferre, Vanesa Izquierdo, Antonio Camins, Coral Sanfeliu, Mercè Pallàs
Inflammation and oxidative stress are key points in age progression. Both processes impact negatively in cognition and in brain functions. Resveratrol (RV) has been postulated as a potent antioxidant natural compound, with rejuvenating properties. Inducing a metabolic stress by high fat (HF) diet in aged C56/BL6 (24 months) led to cognitive disturbances compared with control age mated and with young mice. These changes were prevented by RV. Molecular determinations demonstrated a significant increase in some inflammatory parameters (TNF-α, Cxcl10, IL-1, IL-6, and Ccl3) in old mice but slight changes in oxidative stress machinery...
December 21, 2016: Rejuvenation Research
Nicola Veronese, Sara Fernando-Watutantrige, Stefania Maggi, Marianna Noale, Brendon Stubbs, Raffaele Antonelli Incalzi, Sabina Zambon, Maria Chiara Corti, Egle Perissinotto, Gaetano Crepaldi, Enzo Manzato, Giuseppe Sergi
High or low thyroid-stimulating hormone (TSH) levels seem to be associated with several negative outcomes in the elderly, but the literature about TSH and frailty is still limited. In this article, we investigated whether TSH is associated with prevalent and incident frailty in a cohort of older community-dwelling subjects. Among 3099 initially screened in the Progetto Veneto Anziani Study, 2571 men and women aged ≥65 years (for cross-sectional analyses) and 1732 (longitudinal, mean follow-up period of 4...
December 21, 2016: Rejuvenation Research
Takayuki Matsumoto, Shun Watanabe, Shota Kobayashi, Makoto Ando, Kumiko Taguchi, Tsuneo Kobayashi
Vascular dysfunction is a common finding in type 2 diabetes, although the response to urotensin II (UII), a potent vasoconstrictor peptide, remains unclear. We investigated whether a UII-induced contraction was increased in the aortas from type 2 diabetic Goto-Kakizaki (GK) rats at the chronic stage. At 36 or 37 weeks of age (older group), a UII-induced contraction was seen in GK rats and was reduced by a Rho kinase inhibitor or urotensin receptor (UT) antagonist, whereas UII failed to induce a contraction in aortas from age-matched Wistar rats...
December 20, 2016: Rejuvenation Research
Laurence Genton, Kristina Norman, Adrian Spoerri, Claude Pichard, Véronique L Karsegard, François R Herrmann, Christophe E Graf
BACKGROUND: Phase angle measured by bioelectrical impedance analysis (BIA) may be a marker of health state. OBJECTIVE: This historical cohort study of prospectively collected BIA measurements aims to investigate the link between phase angle and mortality in older people and evaluate whether a phase angle cutoff can be defined. DESIGN: We included all adults aged ≥65 years who underwent a BIA measurement by the Nutriguard(®) device at the Geneva University Hospitals...
December 2, 2016: Rejuvenation Research
Hamzeh Pasban-Aliabadi, Saeed Esmaeili-Mahani, Mehdi Abbasnejad
Parkinson's disease (PD) is a common neurodegenerative disorder characterized by progressive and selective death of dopaminergic neurons. Multifunctional neuropeptide orexin-A is involved in many biological events of the body. It has been shown that orexin-A has protective effects in neurodegenerative disease such as PD. However, its cellular mechanisms have not yet been fully clarified. Here, we investigated the intracellular signaling pathway of orexin-A neuroprotection in 6-OHDA-induced SH-SY5H cells damage as an in vitro model of PD...
November 4, 2016: Rejuvenation Research
Aubrey D N J de Grey
No abstract text is available yet for this article.
December 2016: Rejuvenation Research
Andrew R Mendelsohn, James W Larrick
Spatial memory and cognition decline during aging. Montelukast, an FDA approved drug for the treatment of asthma, can restore spatial memory in old rats to levels similar to those of young animals. Treatment improves three hallmarks of aging in the brain: reducing microglial-mediated neuroinflammation, blood-brain barrier (BBB) permeability, and increasing neurogenesis in the hippocampus although not completely to youthful levels. Other aging-associated parameters, such as reduced synaptic density, are not affected, suggesting that anti-aging therapeutics may be further optimized...
December 2016: Rejuvenation Research
(no author information available yet)
No abstract text is available yet for this article.
December 2016: Rejuvenation Research
Benjamin Zealley, Aubrey D N J de Grey
No abstract text is available yet for this article.
December 2016: Rejuvenation Research
Xiangying Kong, Xiaomin Li, Cun Zhang, Liuluan Zhu, Hongye Wan, Jia Zhu, Cuiling Liu, Hongchang Su, Qingxia Qin, Weiheng Chen, Na Lin
Our recent studies have shown that Huogu (HG) formula was effective both in clinic experience and in experimental osteonecrosis of the femoral head (ONFH). Given that defective of bone marrow stromal cells (MSCs) contribute to the development of osteonecrosis and MSCs show enormous potential in the treatment of ONFH, especially to aging people. How HG impacts the differentiation of MSCs and what is the underlying cellular and molecular mechanism remains largely unknown. Here, we found that an aqueous fraction of HG (HGA) significantly increased the alkaline phosphatase (ALP) activity, mineralized nodules, and migration of MSCs in a dose-dependent manner...
December 2016: Rejuvenation Research
Fang Li, Xianjie Zheng, Xiaoxue Fan, Kefeng Zhai, Yisha Tan, Junping Kou, Boyang Yu
The YiQiFuMai powder injection (YQFM), a traditional Chinese medicine (TCM) prescription re-developed based on the well-known TCM formula Sheng-maisan, showed a wide range of pharmacological activities in cardiovascular diseases in clinics. However, its role in protection against myocardial ischemia/reperfusion (MI/R) injury has not been elucidated. The present study not only evaluated the cardioprotective effect of YQFM from MI/R injury but also investigated the potential molecular mechanisms both in vivo and in vitro...
December 2016: Rejuvenation Research
Cinzia Giuli, Roberta Papa, Fabrizia Lattanzio, Demetrio Postacchini
Cognitive decline and dementia represent very important public health problems that impact the ability to maintain social function and independent living. The aim of this study was to investigate the effects of a nonpharmacological intervention consisting of comprehensive cognitive training in elderly people having one of three different cognitive statuses. In all, 321 elderly people with a diagnoses of mild-moderate Alzheimer's disease (AD), with mild cognitive impairment (MCI) and without cognitive decline were randomly assigned to two groups: experimental group (EG, who underwent intervention) and control group (CG), according to a prospective randomized intervention study...
December 2016: Rejuvenation Research
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