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Rejuvenation Research

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https://www.readbyqxmd.com/read/29207913/generation-of-dopamine-secreting-cells-from-human-adipose-tissue-derived-stem-cells-in-vitro
#1
Mohammad Hasan Soheilifar, Arash Javeri, Hossein Amini, Masoumeh Fakhr Taha
Several studies have demonstrated the differentiation of human adipose tissue-derived stem cells (hADSCs) to neuronal and glial phenotypes, but directing the fate of these cells toward dopaminergic neurons has not been frequently reported. The aim of the present study was to investigate dopaminergic specification of hADSCs in vitro. ADSCs were isolated from subcutaneous abdominal adipose tissue and were characterized. For dopaminergic differentiation, a cocktail of sonic hedgehog, fibroblast growth factor 8, basic fibroblast growth factor and brain-derived neurotrophic factor were used under a low serum condition...
December 5, 2017: Rejuvenation Research
https://www.readbyqxmd.com/read/29207899/effect-of-a-mat-pilates-program-with-theraband%C3%A2-on-dynamic-balance-in-patients-with-parkinson-s-disease-feasibility-study-and-randomized-controlled-trial
#2
Irimia Mollinedo, Jose Maria Cancela, María Helena Vila Suarez
OBJECTIVES: The aim of this study is to assess the effect of a physical exercise program based on Mat Pilates with TheraBand® on the dynamic balance of a sample population diagnosed with Parkinson's Disease (PD). METHOD: After random selection, 26 participants were allocated to a Mat Pilates group or a control group where they performed calisthenics exercises. Both interventions lasted 12 weeks and involved two weekly sessions of 60 minutes. Assessments took place at baseline, 12 weeks after the intervention started and 4 weeks after the intervention was completed using the Body Mass Index (BMI), the Timed Up and Go (TUG) test with Wiva® sensors, the 30 Second Chair Stand test and the Five Times Sit to Stand test...
December 5, 2017: Rejuvenation Research
https://www.readbyqxmd.com/read/29205086/well-meaning-dinosaurs-the-most-potent-enemies-of-progress-against-aging
#3
Aubrey D N J de Grey
n/a.
December 5, 2017: Rejuvenation Research
https://www.readbyqxmd.com/read/29191108/a-screening-tool-using-five-risk-factors-was-developed-for-fall-risk-prediction-in-chinese-community-dwelling-elderly-individuals
#4
Li Kang, Xiaoyu Chen, Peipei Han, Yixuan Ma, Liye Jia, Liyuan Fu, Hairui Yu, Lu Wang, Lin Hou, Xing Yu, Zongyang An, Xuetong Wang, Lu Li, Yuanyuan Zhang, Peng Zhao, Qi Guo
OBJECTIVE: The objective of this study was to determine falls risk profiles to derive a falls risks prediction score and establish a simple and practical clinical screening tool for Chinese community-dwelling elderly individuals. METHOD: This was a prospective cohort study (N=619) among adults aged 60 years and older. Falls were ascertained at a 1-year follow-up appointment. Sociodemographic information, medical history and physical performance data were collected...
November 30, 2017: Rejuvenation Research
https://www.readbyqxmd.com/read/29179649/mesenchymal-stem-cells-for-frailty
#5
James Larrick, Andrew R Mendelsohn
Frailty is a medical syndrome associated with advancing age characterized by reduced functional reserve, strength, endurance and susceptibility to infection associated with high morbidity, hospitalization and death. Non-specific interventions to improve the healthspan of affected patients include physical therapy, exercise, improved nutrition, etc. Among the hallmarks of aging, depletion of stem cells with resultant compromise of regeneration and repair of tissues informs a rational stem cell-based replacement strategy...
November 27, 2017: Rejuvenation Research
https://www.readbyqxmd.com/read/29137544/effect-of-aerobic-training-on-peak-oxygen-uptake-among-seniors-aged-70-or-over-a-meta-analysis-of-randomized-controlled-trials
#6
Walid Bouaziz, Lukshe Kanagaratnam, Thomas Vogel, Elise Schmitt, Moustapha Dramé, Georges Kaltenbach, Bernard Geny, Pierre Olivier Lang
Older adults undergo a progressive decline in cardiorespiratory fitness and functional capacity. This lower peak oxygen uptake (VO2peak) level is associated with increased risk of frailty, dependency, loss of autonomy, and mortality from all causes. Regular physical activity and particularly aerobic training (AT) has been shown to contribute to better and healthy ageing. We conducted a meta-analysis in order to measure the exact benefit of AT on VO2peak in seniors aged 70 years or over. A comprehensive, systematic database search for manuscripts was performed in Embase, Medline, PubMed Central, ScienceDirect, Scopus, and Web of Science using key words...
November 14, 2017: Rejuvenation Research
https://www.readbyqxmd.com/read/29125070/circulating-mitochondrial-dna-at-the-crossroads-of-mitochondrial-dysfunction-and-inflammation-during-aging-and-muscle-wasting-disorders
#7
Anna Picca, Angela Maria Serena Lezza, Christiaan Leeuwenburgh, Vito Pesce, Riccardo Calvani, Maurizio Bossola, Ester Manes-Gravina, Francesco Landi, Roberto Bernabei, Emanuele Marzetti
Mitochondrial structural and functional integrity is maintained through the coordination of several processes (e.g., biogenesis, dynamics, mitophagy), collectively referred to as mitochondrial quality control. Dysfunctional mitochondrial quality control and inflammation are hallmarks of aging and are involved in the pathogenesis of muscle wasting disorders, including sarcopenia and cachexia. One of the consequences of failing mitochondrial quality control is the release of mitochondria-derived damage-associated molecular patterns...
November 10, 2017: Rejuvenation Research
https://www.readbyqxmd.com/read/29125039/astrocyte-autophagy-flux-protects-neurons-against-oxygen-glucose-deprivation-and-ischemic-reperfusion-injury
#8
Xue Liu, Fengfeng Tian, Shiquan Wang, Feng Wang, Lize Xiong
The role of autophagy varies with the type of acute brain injury. In general, autophagy mediates a clear neuroprotective effect in intoxication caused by various psychoactive agents, subarachnoid hemorrhage and spinal cord injury. In contrast, autophagic cell death has also been reported to actively contribute to neuronal loss in neonatal hypoxic ischemic encephalopathy. However, it still remains to be determined whether autophagy pays a cytoprotective or a cytotoxic role in stroke. Previous studies focused primarily on the role of neurons rather than the role of astrocytes in brain injury...
November 10, 2017: Rejuvenation Research
https://www.readbyqxmd.com/read/28548620/baicalein-exerts-beneficial-effects-in-d-galactose-induced-aging-rats-through-attenuation-of-inflammation-and-metabolic-dysfunction
#9
Dan-Dan Duan, Ke-Xin Wang, Yu-Zhi Zhou, Xue-Mei Qin, Li Gao, Guan-Hua Du
Baicalein is a flavonoid isolated from the roots of Scutellaria baicalensis Georgi. This study aimed to ascertain the effects and potential underlying mechanisms of baicalein in d-galactose (d-gal)-induced aging rat model by integration of behavior examination, biochemical detection, and (1)H nuclear magnetic resonance (NMR)-based metabolomic approach. Our findings suggest that baicalein significantly attenuated memory decline in d-gal-induced aging model, as manifested by increasing recognition index in novel object recognition test, shortening latency time, and increasing platform crossings in Morris water maze test...
November 8, 2017: Rejuvenation Research
https://www.readbyqxmd.com/read/29251573/commentary-on-some-recent-theses-relevant-to-combating-aging-december-2017
#10
Benjamin Zealley, Aubrey D N J de Grey
No abstract text is available yet for this article.
December 2017: Rejuvenation Research
https://www.readbyqxmd.com/read/29048250/inhibition-of-abeta-proteotoxicity-by-paeoniflorin-in-i-caenorhabditis-elegans-i-through-regulation-of-oxidative-and-heat-shock-stress-responses
#11
Liping Ai, Fan Yang, Jie Song, Yan Chen, Lingyun Xiao, Qiangqiang Wang, Liangyi Wang, Haifeng Li, Tao Lei, Zebo Huang
Alzheimer's disease (AD) is a common form of dementia and amyloid-β peptide (Aβ) aggregation is considered to be one of its main causes. Paeoniflorin has been previously shown to attenuate cognitive damage inflicted by exogenous Aβ protein. Using transgenic <i>Caenorhabditis elegans</i> models expressing human Aβ1-42, we demonstrate here that paeoniflorin can delay progressive paralysis caused by endogenous Aβ expression and reduce the amount of toxic Aβ oligomers in vivo although it has no effect on Aβ aggregation <i>in vitro</i>...
October 19, 2017: Rejuvenation Research
https://www.readbyqxmd.com/read/28994636/meetings-calendar-2017
#12
(no author information available yet)
No abstract text is available yet for this article.
October 10, 2017: Rejuvenation Research
https://www.readbyqxmd.com/read/28851251/targeting-aging-with-functional-food-pasta-with-opuntia-single-arm-pilot-study
#13
Anna Aiello, Danilo Di Bona, Giuseppina Candore, Ciriaco Carru, Angelo Zinellu, Giuseppe Di Miceli, Aldo Nicosia, Caterina Maria Gambino, Paolo Ruisi, Calogero Caruso, Sonya Vasto, Giulia Accardi
Interventions to extend life span represent the new perspective in aging investigation. Healthy dietary habits are important modifiable factors that can favor a healthy aging phenotype. Many studies have demonstrated benefits for metabolic syndrome and type 2 diabetes mellitus resulting from the traditional Mediterranean foods. Opuntia Ficus Indica (OFI), widespread in the Mediterranean basin, belongs to the Cactaceae family. It is known for its antioxidant and anti-inflammatory properties. Moreover, products containing extracts from OFI fruits or cladodes have been used to control obesity and other metabolic parameters, such as glycemia and lipid profile...
October 10, 2017: Rejuvenation Research
https://www.readbyqxmd.com/read/28982278/use-of-medaka-fish-as-vertebrate-model-to-study-the-effect-of-cocoa-polyphenols-in-the-resistance-to-oxidative-stress-and-lifespan-extension
#14
Ana Virginia Sánchez-Sánchez, Aránzazu Leal-Tassias, Neus Rodríguez-Sánchez, Marina Piquer-Gil, Patricia Martorell, Salvador Genovés, Carlos Acosta, Deborah Burks, Daniel Ramón, José Luis Mullor
Oxidative stress can induce cell apoptosis and thus, plays an important role in aging. Antioxidant foods protect tissues from oxidative stress and contribute to a healthier life style. Here we described the used of medaka embryos (Oryzias latipes) to study the putative antioxidant capacity of dietary cocoa extract in vertebrates. A polyphenol-enriched cocoa extract regulated the expression of several genes implicated in oxidative stress, thereby protecting fish embryos from induced oxidative stress. The cocoa extract activated SOD enzyme activity in embryos and in adult fish tissues, suggesting a common mechanism for protection during embryonic development and adulthood...
October 6, 2017: Rejuvenation Research
https://www.readbyqxmd.com/read/29053441/response-to-milholland-et-al-rejuvenation-res-2017-20-437-440
#15
Aubrey D N J de Grey
No abstract text is available yet for this article.
October 2017: Rejuvenation Research
https://www.readbyqxmd.com/read/28982266/-best-guess-mrad-provides-robust-evidence-for-a-limit-to-human-lifespan-reply-to-de-grey-rejuvenation-res-2017-20-261-262
#16
Brandon Milholland, Xiao Dong, Jan Vijg
Using segmented linear regression to reanalyze the "best-guess" maximum reported age at death data supplied in Aubrey de Grey's editorial, we find compelling evidence for a breakpoint in the mid-1990s, with a positive slope before the breakpoint and a flat or slightly negative slope after it. This confirmation of our earlier results was also modeled using exponential regression. Both the segmented and exponential models were superior to a simple linear regression, providing a better fit for the data even after taking into account their greater number of parameters...
October 2017: Rejuvenation Research
https://www.readbyqxmd.com/read/28954593/is-there-a-need-for-scientific-education-in-the-aging-field
#17
Christos C Zouboulis
No abstract text is available yet for this article.
October 2017: Rejuvenation Research
https://www.readbyqxmd.com/read/28942711/epigenetic-drift-is-a-determinant-of-mammalian-lifespan
#18
Andrew R Mendelsohn, James W Larrick
The epigenome, which controls cell identity and function, is not maintained with 100% fidelity in somatic animal cells. Errors in the maintenance of the epigenome lead to epigenetic drift, an important hallmark of aging. Numerous studies have described DNA methylation clocks that correlate epigenetic drift with increasing age. The question of how significant a role epigenetic drift plays in creating the phenotypes associated with aging remains open. A recent study describes a new DNA methylation clock that can be slowed by caloric restriction (CR) in a way that correlates with the degree of lifespan and healthspan extension conferred by CR, suggesting that epigenetic drift itself is a determinant of mammalian lifespan...
October 2017: Rejuvenation Research
https://www.readbyqxmd.com/read/28602152/physical-activity-and-cognitive-function-of-long-distance-walkers-studying-four-days-marches-participants
#19
Hans Wouters, Teun Aalbers, Martijn F H Maessen, André L M Verbeek, Marcel G M Olde Rikkert, Roy P C Kessels, Maria T E Hopman, Thijs M H Eijsvogels
Studies show physical activity to be beneficial for cognitive function. However, studies usually included individuals who were not particularly inclined to exercise. Following research among master athletes, we examined associations between physical activity and cognitive function in participants of the International Nijmegen Four Days Marches. These individuals are also inclined to exercise. On 4 consecutive days >40,000 participants walk a daily distance of 30-50 km (120-200 km or 75-125 miles in total)...
October 2017: Rejuvenation Research
https://www.readbyqxmd.com/read/28514891/synergistic-effect-of-rapamycin-and-metformin-against-age-dependent-oxidative-stress-in-rat-erythrocytes
#20
Abhishek Kumar Singh, Geetika Garg, Sandeep Singh, Syed Ibrahim Rizvi
Erythrocytes are particularly vulnerable toward age-dependent oxidative stress-mediated damage. Caloric restriction mimetics (CRMs) may provide a novel strategy for the maintenance of redox balance as well as effective treatment of age-associated diseases. Herein, we have investigated the beneficial effect of cotreatment with CRM-candidate drugs, rapamycin (an immunosuppressant drug and inhibitor of mammalian target of rapamycin) and metformin (an antidiabetic biguanide and activator of adenosine monophosphate kinase), against aging-induced oxidative stress in erythrocytes and plasma of aging rats...
October 2017: Rejuvenation Research
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