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Rejuvenation Research

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https://www.readbyqxmd.com/read/28741449/meetings-calendar
#1
Aubrey D N J de Grey
n/a.
July 25, 2017: Rejuvenation Research
https://www.readbyqxmd.com/read/28741440/commentary-on-some-recent-theses-relevant-to-combating-aging-august-2017
#2
Benjamin Zealley, Aubrey D N J de Grey
Theses reviewed in this issue include "Engineering Cellular Input-Output for the Robust Control of Mammalian Cell-Based Therapies"; "Enzyme-Instructed Self-Assembly (EISA) Selectively Targets Cancer Cells"; "Exploration of helminth-derived immunoregulatory molecules as options for therapeutic intervention in allograft rejection and autoimmune disease"; "Expression of the Medial HOXA genes is indispensible for self-renewal in human hematopoietic stem cells"; "Gamma frequency entrainment attenuates amyloid load and modifies microglia"; and "Heterogeneous Distribution of Microvascular Blood Flow Contributes to Impaired Skeletal Muscle Oxygenation in Diabetes"...
July 25, 2017: Rejuvenation Research
https://www.readbyqxmd.com/read/28622086/naringenin-ameliorates-behavioral-dysfunction-and-neurological-deficits-in-a-d-galactose-induced-aging-mouse-model-through-activation-of-pi3k-akt-nrf2-pathway
#3
Yan Zhang, Bin Liu, Xi Chen, Ning Zhang, Guang Li, Li-Hong Zhang, Li-Yan Tan
In this study, we evaluated the protective effects of naringenin on aging mice induced by d-galactose (d-gal). Open field test and Morris water maze test were performed to evaluate the effect of naringenin on behavioral dysfunction. Hematoxylin-eosin staining, TUNEL staining, and Nissl staining were used to estimate the effect of naringenin on neurological deficits. Furthermore, naringenin markedly activated PI3K/Akt signaling, eventually promoted the nuclear translocation of nuclear factor-erythroid 2-related factor 2, and induced the expression of heme oxygenase 1 and NAD(P)H-quinone oxidoreductase 1...
July 24, 2017: Rejuvenation Research
https://www.readbyqxmd.com/read/28602152/physical-activity-and-cognitive-function-of-long-distance-walkers-studying-four-days-marches-participants
#4
Hans Wouters, Teun Aalbers, Martijn F H Maessen, André L M Verbeek, Marcel G M Olde Rikkert, Roy P C Kessels, Maria T E Hopman, Thijs M H Eijsvogels
Studies show physical activity to be beneficial for cognitive function. However, studies usually included individuals who were not particularly inclined to exercise. Following research among master athletes, we examined associations between physical activity and cognitive function in participants of the International Nijmegen Four Days Marches. These individuals are also inclined to exercise. On 4 consecutive days >40,000 participants walk a daily distance of 30-50 km (120-200 km or 75-125 miles in total)...
July 24, 2017: Rejuvenation Research
https://www.readbyqxmd.com/read/28728538/effects-of-cataract-opacity-and-surgery-on-sleep-quality
#5
Aya Kokune, Masahiko Ayaki, Kazuo Tsubota, Kazuno Negishi
BACKGROUND: This study aimed to identify the type of cataract opacity associated with subjective sleep quality for cataract patients. METHODS: A total of 180 consecutive patients (average age 74.2 years) underwent cataract surgery with implantation of a UV-blocking or blue light-blocking intra ocular lens. The participants' subjective sleep quality was evaluated using the Pittsburgh sleep quality index (PSQI) before and at 2 months after surgery. Patients were divided into two groups for analysis: normal sleepers (preoperative PSQI ≤ 5) and poor sleepers (preoperative PSQI ≥ 6)...
July 20, 2017: Rejuvenation Research
https://www.readbyqxmd.com/read/28728479/stem-cells-and-other-emerging-agents-as-innovative-drugs-in-neurodegenerative-diseases-benefits-and-limitations
#6
Martina Nasello, Giuseppe Schirò, Floriana Crapanzano, Carmela Rita Balistreri
Brain has a limited process of repair/regeneration linked to the restricted and localized activity of neuronal stem cells (NSCs).Consequently, it shows a reduced capacity to counteract the age-related loss of neural and glial cells and to repair the consequent injuries/lesions of nervous system. This progressively determines nervous dysfunction and onset/progression of neurodegenerative diseases, which represent a serious social (and economic) problem of our populations. Thus, the research of efficient treatments is encouraged...
July 20, 2017: Rejuvenation Research
https://www.readbyqxmd.com/read/28712336/clinical-and-histological-studies-of-suborbital-wrinkles-treated-with-fractional-bipolar-radiofrequency
#7
Jun Huang, Wenyou Yu, Zhen Zhang, Xiaodong Chen, Ewelina Biskup
Fractional bipolar radiofrequency (FRF) has been well established for facial rejuvenation, but there is no report showing its efficacy for the treatment of suborbital wrinkles. The aim of this study was to investigate and objectively evaluate the clinical efficacy and side effects of FRF for the treatment of suborbital wrinkles, including observation of histological changes of the suborbital skin along the therapy. 32 female patients with suborbital wrinkles underwent 3 sessions of FRF at 3-week intervals with a follow-up period of 6 months after treatment...
July 16, 2017: Rejuvenation Research
https://www.readbyqxmd.com/read/28712331/feasibility-and-efficacy-of-mat-pilates-on-people-with-mild-to-moderate-parkinson-s-disease-a-preliminary-study
#8
Jose Maria Cancela, Irimia Mollinedo, Carlos Ayán Perez, Iris Machado de Oliveira
OBJECTIVES: This pilot study aimed at assessing the feasibility and efficacy of a Mat Pilates program in people with mild to moderate Parkinson's disease. Equipment and methods: The participants carried out a Mat Pilates program twice a week for 12 weeks. The Senior Fitness Test battery and the 39-item Parkinson's Disease Questionnaire were used to assess the effects of the program on the participants' fitness level and quality of life. RESULTS: A total of 16 patients with mild to moderate Parkinson's disease volunteered and finished the study...
July 16, 2017: Rejuvenation Research
https://www.readbyqxmd.com/read/28673122/rejuvenating-effect-of-long-term-igf-i-gene-therapy-in-the-hypothalamus-of-aged-rats-with-dopaminergic-dysfunction
#9
Jose Ignacio Schwerdt, Micaela Lopez-Leon, Gloria Miriam Console, Oscar Alfedo Brown, Gustavo Ramon Morel, Eduardo Spinedi, Rodolfo Gustavo Goya
The aging female rat constitutes an interesting model of spontaneous and progressive age-related dopaminergic dysfunction as it allows assessing new therapeutic strategies for Parkinson's disease. Insulin-like growth factor I (IGF-I) is emerging as a powerful neuroprotective molecule which is strongly induced in the central nervous system after different insults. We constructed a helper-dependent recombinant adenoviral vector (HDRAd-IGFI) harboring the gene for rat IGF-I. This was used it to implement long-term IGF-I gene therapy in the hypothalamus of aged female rats, which display hypothalamic dopaminergic (DA) dysfunction and as a consequence, chronic hyperprolactinemia...
July 3, 2017: Rejuvenation Research
https://www.readbyqxmd.com/read/28661208/natural-substances-for-prevention-of-skin-photo-ageing-screening-systems-in-the-development-of-sunscreen-and-rejuvenation-cosmetics
#10
Vladimir A Kostyuk, Alla I Potapovich, Ahmed R Albuhaydar, Wolfgang Mayer, Chiara De Luca, Liudmila G Korkina
Solar broad-band UV irradiation is commonly regarded as a major causative reason for cutaneous photo-ageing. The pro-ageing molecular pathways and cellular targets affected by UVA+UVB light in human skin have been extensively investigated. Notwithstanding growing knowledge in mechanisms of photo-ageing, research and development of clinically efficient, non-toxic and sustainable topical preparations providing full physical, chemical, and biological photo-protection still remain a great challenge for pharmaceutical and cosmetic industries...
June 29, 2017: Rejuvenation Research
https://www.readbyqxmd.com/read/28661207/thyroid-function-in-ageing-a-discerning-approach
#11
Leonidas H Duntas
XX.
June 29, 2017: Rejuvenation Research
https://www.readbyqxmd.com/read/28498017/dietary-supplements-as-surrogate-of-mediterranean-diet-in-healthy-smoking-subjects
#12
Sonya Vasto, Giulia Accardi, Anna Aiello, Francesca Di Gaudio, Annalisa Barera, Serena Indelicato, Damiano Galimberti, Emilio Italiano, Roberto Monastero, Claudia Rizzo, Calogero Caruso, Giuseppina Candore
The interventions to slow ageing, favoring active life expectancy, represent the new perspectives in ageing investigation. Some mechanisms that delay or prevent the onset of ageing pathologies have been identified. Between them, a healthy lifestyle seems to reduce many risk factors. In particular, eating habits represent the most concrete, low-cost way to act on ageing process. Mediterranean diet has received much attention since its antioxidant and anti-inflammatory effects have been consistently demonstrated...
June 26, 2017: Rejuvenation Research
https://www.readbyqxmd.com/read/28648126/knee-osteoarthritis-and-risk-of-hypertension-a-longitudinal-cohort-study
#13
Nicola Veronese, Brendon Stubbs, Marco Solmi, Toby Smith, Marianna Noale, Patricia Schofield, Stefania Maggi
Whilst previous research has indicated an association between osteoarthritis and cardiovascular disease, it remains unclear whether people with osteoarthritis are at greater risk of developing hypertension. The aim of this study was to answer this uncertainity. We used the data of the Osteoarhritis Iniative, an ongoing public and private longitudinal study including people at higher risk of osteoarthritis or having knee osteoarthritis. Knee osteoarthritis was defined through radiological and clinical assessment...
June 24, 2017: Rejuvenation Research
https://www.readbyqxmd.com/read/28635539/an-old-challenge-with-new-promises-a-systematic-review-on-comprehensive-geriatric-assessment-in-long-term-care-facilities
#14
Francesco Panza, Vincenzo Solfrizzi, Madia Lozupone, Maria Rosaria Barulli, Francesca D'Urso, Roberta Stallone, Vittorio Dibello, Alessia Noia, Cristina Di Dio, Antonio Daniele, Antonello Bellomo, Davide Seripa, Antonio Greco, Giancarlo Logroscino
Comprehensive geriatric assessment (CGA) is a multidimensional and multidisciplinary diagnostic process focused on determining the clinical profile, pathological risk, residual skills, short- and long-term prognosis, and the personalized therapeutic and care plan of the functionally compromised and frail older subjects. Previous evidence suggested that the effectiveness of CGA programs may be influenced by the settings where the CGA is performed [i.e., hospital, post-hospital discharge/ long-term care facilities (LTCF), or community/home] as well as the specific clinical conditions of older frail individuals...
June 21, 2017: Rejuvenation Research
https://www.readbyqxmd.com/read/28629266/polygonatum-sibiricum-polysaccharide-promotes-osteoblastic-differentiation-through-the-erk-gsk-3%C3%AE-%C3%AE-catenin-signaling-pathway-in-vitro
#15
Xiaoming Peng, Jichen He, Jinmin Zhao, Yunle Wu, Xiongzhi Shi, Li Du, Mengni Nong, Shaohui Zong, Gao-Feng Zeng
Natural compound Polygonatum sibiricum polysaccharide (PSP) has a variety of biological actions such as reducing blood fat, antitumor, antioxidant activities, and enhancing immune function. In our previous study has revealed that PSP can promote osteoblastic differentiation in bone mesenchymal stem cells (BMSCs) by increasing nuclear accumulation of β-catenin. This study was designed to investigate that PSP can upregulate nuclear β-catenin, which was prevented by inhibiting glycogen synthase kinase 3β (GSK-3β) activity, by effectively activating Wnt signaling independent of low-density lipoprotein receptor-related protein (LRP5) ...
June 19, 2017: Rejuvenation Research
https://www.readbyqxmd.com/read/28482746/neuromuscular-electrical-stimulation-combined-with-protein-ingestion-preserves-thigh-muscle-mass-but-not-muscle-function-in-healthy-older-adults-during-5-days-of-bed-rest
#16
Paul T Reidy, Alec I McKenzie, Preston Brunker, Daniel S Nelson, Katherine M Barrows, Mark Supiano, Paul C LaStayo, Micah J Drummond
Short-term bed rest in older adults is characterized by significant loss in leg lean mass and strength posing significant health consequences. The purpose of this study was to determine in healthy older adults if the daily combination of neuromuscular electrical stimulation and protein supplementation (NMES+PRO) would protect muscle mass and function after 5 days of bed rest. Twenty healthy older adults (∼70 years) were subjected to 5 days of continuous bed rest and were randomized into one of two groups: NMES+PRO (n = 10) or control (CON) (n = 10)...
June 19, 2017: Rejuvenation Research
https://www.readbyqxmd.com/read/28482745/lifecourse-adversity-and-telomere-length-in-older-women-from-northeast-brazil
#17
Bruna Silva Oliveira, Maria Victoria Zunzunegui, Jacklyn Quinlan, Silvia Regina Batistuzzo de Medeiros, Ronaldo Luis Thomasini, Ricardo Oliveira Guerra
We examined associations between adverse childhood experiences (ACEs) and shorter telomere length (TL) in 83 older women, including 42 women with less than secondary education and 41 with secondary or more education in a city of Northeast Brazil, a region with substantial socioeconomic inequalities. The low education sample was selected from a representative survey at local neighborhood health centers, while the high education group consisted of a convenience sample recruited by advertising in community centers and centers affiliated with the local university...
June 19, 2017: Rejuvenation Research
https://www.readbyqxmd.com/read/28482740/effects-of-three-different-chair-based-exercise-programs-on-people-older-than-80-years
#18
José M Cancela Carral, Estrella Pallin, Ander Orbegozo, Carlos Ayán Pérez
This study aimed at comparing the effects of three chair-based exercise programs on people older than 80 years. Thirty-six participants (87.91 ± 4.70 years) were randomly allocated to an aerobic, muscular resistance, or joint mobility exercise program. The participants exercised 3 days per week during 3 months. A hand-held dynamometer, the Tinetti Gait Balance, the Barthel Index, and the Timed Up and Go Test (TUG) (assessed by means of the Wiva(®) science sensor) were used to evaluate the effects of the programs on the participants' strength, balance, functional independence, and functional mobility, respectively...
June 19, 2017: Rejuvenation Research
https://www.readbyqxmd.com/read/28622077/a-comparative-study-of-the-effects-of-sodium-selenite-and-glutathione-mono-ethyl-ester-on-aged-adipose-derived-stem-cells-the-telomerase-and-cellular-responses
#19
N Aminizadeh, Taki M Tiraihi, S A Mesbah-Namin, Taher Taheri
The proliferation and differentiation potential of adipose derived stem cells (ADSCs) declines with ageing. Moreover, Alzheimer's disease is associated with progressive decline in cholinergic neurons. The purpose of this study is to enhance the proliferation potential of aged rat ADSCs and their differentiation into cholinergic neurons. The ADSCs were collected from aged male rats cultured and treated with different concentrations of sodium selenite for 3 days or glutathione mono ethyl ester (GSH-MEE) for 1 day...
June 16, 2017: Rejuvenation Research
https://www.readbyqxmd.com/read/28602121/frailty-and-risk-of-cardiovascular-diseases-in-older-persons-the-age-gene-environment-susceptibility-reykjavik-study
#20
Nicola Veronese, Kristin Sigeirsdottir, Gudny Eiriksdottir, Elisa Marques, Didier Chalhoub, Caroline Phillips, Lenore Launer, Stefania Maggi, Vilmundur Gudnason, Tamara B Harris
Frailty is a risk factor for cardiovascular diseases (CVD), but the studies available have not considered the presence of sub-clinical atherosclerotic disease as potential confounders. We investigated the association between frailty and the onset of CVD independently of sub-clinical atherosclerotic disease. For this reason, a sample of 3818 older participants participating in the Age, Gene/Environment SusceptibilityReykjavik Study (AGESReykjavik) without CVD at baseline was followed for a median of 8...
June 10, 2017: Rejuvenation Research
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