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Rejuvenation Research

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https://www.readbyqxmd.com/read/28635539/an-old-challenge-with-new-promises-a-systematic-review-on-comprehensive-geriatric-assessment-in-long-term-care-facilities
#1
Francesco Panza, Vincenzo Solfrizzi, Madia Lozupone, Maria Rosaria Barulli, Francesca D'Urso, Roberta Stallone, Vittorio Dibello, Alessia Noia, Cristina Di Dio, Antonio Daniele, Antonello Bellomo, Davide Seripa, Antonio Greco, Giancarlo Logroscino
Comprehensive geriatric assessment (CGA) is a multidimensional and multidisciplinary diagnostic process focused on determining the clinical profile, pathological risk, residual skills, short- and long-term prognosis, and the personalized therapeutic and care plan of the functionally compromised and frail older subjects. Previous evidence suggested that the effectiveness of CGA programs may be influenced by the settings where the CGA is performed [i.e., hospital, post-hospital discharge/ long-term care facilities (LTCF), or community/home] as well as the specific clinical conditions of older frail individuals...
June 21, 2017: Rejuvenation Research
https://www.readbyqxmd.com/read/28629266/polygonatum-sibiricum-polysaccharide-promotes-osteoblastic-differentiation-through-the-erk-gsk-3%C3%AE-%C3%AE-catenin-signaling-pathway-in-vitro
#2
Xiaoming Peng, Jichen He, Jinmin Zhao, Yunle Wu, Xiongzhi Shi, Li Du, Mengni Nong, Shaohui Zong, Gao-Feng Zeng
Natural compound Polygonatum sibiricum polysaccharide (PSP) has a variety of biological actions such as reducing blood fat, antitumor, antioxidant activities, and enhancing immune function. In our previous study has revealed that PSP can promote osteoblastic differentiation in bone mesenchymal stem cells (BMSCs) by increasing nuclear accumulation of β-catenin. This study was designed to investigate that PSP can upregulate nuclear β-catenin, which was prevented by inhibiting glycogen synthase kinase 3β (GSK-3β) activity, by effectively activating Wnt signaling independent of low-density lipoprotein receptor-related protein (LRP5) ...
June 19, 2017: Rejuvenation Research
https://www.readbyqxmd.com/read/28482746/neuromuscular-electrical-stimulation-combined-with-protein-ingestion-preserves-thigh-muscle-mass-but-not-muscle-function-in-healthy-older-adults-during-5-days-of-bed-rest
#3
Paul T Reidy, Alec I McKenzie, Preston Brunker, Daniel S Nelson, Katherine M Barrows, Mark Supiano, Paul C LaStayo, Micah J Drummond
Short-term bed rest in older adults is characterized by significant loss in leg lean mass and strength posing significant health consequences. The purpose of this study was to determine in healthy older adults if the daily combination of neuromuscular electrical stimulation and protein supplementation (NMES+PRO) would protect muscle mass and function after 5 days of bed rest. Twenty healthy older adults (∼70 years) were subjected to 5 days of continuous bed rest and were randomized into one of two groups: NMES+PRO (n = 10) or control (CON) (n = 10)...
June 19, 2017: Rejuvenation Research
https://www.readbyqxmd.com/read/28482745/lifecourse-adversity-and-telomere-length-in-older-women-from-northeast-brazil
#4
Bruna Silva Oliveira, Maria Victoria Zunzunegui, Jacklyn Quinlan, Silvia Regina Batistuzzo de Medeiros, Ronaldo Luis Thomasini, Ricardo Oliveira Guerra
We examined associations between adverse childhood experiences (ACEs) and shorter telomere length (TL) in 83 older women, including 42 women with less than secondary education and 41 with secondary or more education in a city of Northeast Brazil, a region with substantial socioeconomic inequalities. The low education sample was selected from a representative survey at local neighborhood health centers, while the high education group consisted of a convenience sample recruited by advertising in community centers and centers affiliated with the local university...
June 19, 2017: Rejuvenation Research
https://www.readbyqxmd.com/read/28482740/effects-of-three-different-chair-based-exercise-programs-on-people-older-than-80-years
#5
José M Cancela Carral, Estrella Pallin, Ander Orbegozo, Carlos Ayán Pérez
This study aimed at comparing the effects of three chair-based exercise programs on people older than 80 years. Thirty-six participants (87.91 ± 4.70 years) were randomly allocated to an aerobic, muscular resistance, or joint mobility exercise program. The participants exercised 3 days per week during 3 months. A hand-held dynamometer, the Tinetti Gait Balance, the Barthel Index, and the Timed Up and Go Test (TUG) (assessed by means of the Wiva(®) science sensor) were used to evaluate the effects of the programs on the participants' strength, balance, functional independence, and functional mobility, respectively...
June 19, 2017: Rejuvenation Research
https://www.readbyqxmd.com/read/28622086/naringenin-ameliorates-behavioral-dysfunction-and-neurological-deficits-in-a-d-galactose-induced-aging-mouse-model-through-activation-of-pi3k-akt-nrf2-pathway
#6
Yan Zhang, Bin Liu, Xi Chen, Ning Zhang, Guang Li, Li-Hong Li-Hong Zhang, Li-Yan Li-Yan Tan
In this study, we evaluated the protective effects of naringenin on aging mice induced by D-gal. Open field test and Morris water maze test were performed to evaluate the effect of naringenin on behavioral dysfunction. HE staining, TUNEL staining and Nissl staining were used to estimate the effect of naringenin on neurological deficits. Furthermore, naringenin markedly activated PI3K/Akt signaling, eventually promoted the nuclear translocation of Nrf2 and induced the expressions of HO-1and NQO1. SOD, CAT and TBARS assays were conducted to evaluate oxidative stress in D-gal-induced aging mice...
June 16, 2017: Rejuvenation Research
https://www.readbyqxmd.com/read/28622077/a-comparative-study-of-the-effects-of-sodium-selenite-and-glutathione-mono-ethyl-ester-on-aged-adipose-derived-stem-cells-the-telomerase-and-cellular-responses
#7
N Aminizadeh, Taki M Tiraihi, S A Mesbah-Namin, Taher Taheri
The proliferation and differentiation potential of adipose derived stem cells (ADSCs) declines with ageing. Moreover, Alzheimer's disease is associated with progressive decline in cholinergic neurons. The purpose of this study is to enhance the proliferation potential of aged rat ADSCs and their differentiation into cholinergic neurons. The ADSCs were collected from aged male rats cultured and treated with different concentrations of sodium selenite for 3 days or glutathione mono ethyl ester (GSH-MEE) for 1 day...
June 16, 2017: Rejuvenation Research
https://www.readbyqxmd.com/read/28602152/physical-activity-and-cognitive-function-of-long-distance-walkers-studying-four-days-marches-participants
#8
Hans Wouters, Teun Aalbers, Martijn Maessen, André Verbeek, Marcel Olde Rikkert, Roy Kessels, Maria Hopman, Thijs Eijsvogels
OBJECTIVE: Studies show physical activity to be beneficial for cognitive function. However, studies usually included individuals who were not particularly inclined to exercise. Following research among master athletes, we examined associations between physical activity and cognitive function in participants of the International Nijmegen Four Days Marches. These individuals are also inclined to exercise. On 4 consecutive days > 40,000 participants walk a daily distance of 30-50 km (120-200 km or 75-125 miles in total)...
June 10, 2017: Rejuvenation Research
https://www.readbyqxmd.com/read/28602121/frailty-and-risk-of-cardiovascular-diseases-in-older-persons-the-age-gene-environment-susceptibility-reykjavik-study
#9
Nicola Veronese, Kristin Sigeirsdottir, Gudny Eiriksdottir, Elisa Marques, Didier Chalhoub, Caroline Phillips, Lenore Launer, Stefania Maggi, Vilmundur Gudnason, Tamara B Harris
Frailty is a risk factor for cardiovascular diseases (CVD), but the studies available have not considered the presence of sub-clinical atherosclerotic disease as potential confounders. We investigated the association between frailty and the onset of CVD independently of sub-clinical atherosclerotic disease. For this reason, a sample of 3818 older participants participating in the Age, Gene/Environment SusceptibilityReykjavik Study (AGESReykjavik) without CVD at baseline was followed for a median of 8...
June 10, 2017: Rejuvenation Research
https://www.readbyqxmd.com/read/28514191/commentary-on-some-recent-theses-relevant-to-combating-aging-june-2017
#10
Benjamin Zealley, Aubrey D N J de Grey
No abstract text is available yet for this article.
June 6, 2017: Rejuvenation Research
https://www.readbyqxmd.com/read/28548620/baicalein-exerts-beneficial-effects-in-d-galactose-induced-aging-rats-through-attenuation-of-inflammation-and-metabolic-dysfunction
#11
Dan-Dan Duan, Ke Xin Wang, Yu-Zhi Zhou, Xue-Mei Qin, Li Gao, Guan-Hua Du
Baicalein is a flavonoid isolated from the roots of Scutellaria baicalensis Georgi. This study aimed to ascertain the effects and potential underlying mechanisms of baicalein in D-galactose induced aging rat model by integration of behavior examination, biochemical detection and 1H NMR based metabolomic approach. Our findings suggest that baicalein significantly attenuated memory decline in D-galactose induced aging model, as manifested by increasing recognition index in novel object recognition test, shortening latency time and increasing platform crossings in morris water maze test...
May 26, 2017: Rejuvenation Research
https://www.readbyqxmd.com/read/28537525/when-hypnosis-beats-logic-a-demoralising-geographical-coincidence
#12
Aubrey D N J de Grey
n/a.
May 24, 2017: Rejuvenation Research
https://www.readbyqxmd.com/read/28537507/electroacupuncture-alleviated-brain-damages-through-mir-191a-5p-targeting-neuronal-calcium-sensor-1-after-ischemic-stroke
#13
Heng Zhou, Ceng Yang, Fuhai Bai, Zhi Ma, Jingyi Wang, Feng Wang, Feng Li, Qiang Wang, Lize Xiong
Electroacupuncture (EA) administration before or after cerebral ischemia has been shown to afford protection against ischemic injury. However, the underlying mechanism of EA-mediated protection is still unclear. Functional microRNAs (miRNAs) are believed to play important roles in neuroprotection and synaptic plasticity during and after ischemia. In a previous study, we identified 20 miRNAs that are expressed in the penumbra and are significantly changed after EA treatment. Here, we used bioinformatics analysis to predict the biological functions and gene-networks of these miRNAs...
May 24, 2017: Rejuvenation Research
https://www.readbyqxmd.com/read/28537485/a-nad-parp1-sirt1-axis-in-aging
#14
Andrew R Mendelsohn, James Larrick
NAD+ levels decline with age in diverse animals from C. elegans to mice. Raising NAD+ levels by dietary supplementation with NAD+ precursors NR or NMN improves mitochondrial function and muscle, neural and melanocyte stem cell function in mice as well as increasing murine lifespan. Decreased NAD+ levels with age reduces SIRT1 function and reduces the mitochondrial unfolded protein response, which can be overcome by NR supplementation. Decreased NAD+ levels cause NAD+-binding protein DCB1 to form a complex with PARP1, inhibiting PARP catalytic activity...
May 24, 2017: Rejuvenation Research
https://www.readbyqxmd.com/read/28446042/the-use-of-fibroblasts-for-ameliorating-structural-changes-associated-with-skin-aging
#15
Toshimitsu Itaya, Tatsuo Hirai, Takahisa Hirai, Hideki Numoto, Hideo Takeda, Minoru Ueda
Various causes underlie the structural changes associated with skin aging. To treat these problems, surgical or nonsurgical approaches are available. One of the nonsurgical approaches-regeneration therapy-has become the focus of research and clinical applications. In an earlier clinical study, we injected fibroblasts into the nasolabial region and lips to counter the structural changes associated with skin aging. Assessments performed 12 months after the first injection showed mostly adequate satisfaction scores...
May 24, 2017: Rejuvenation Research
https://www.readbyqxmd.com/read/28514891/synergistic-effect-of-rapamycin-and-metformin-against-age-dependent-oxidative-stress-in-rat-erythrocyte
#16
Abhishek Kumar Singh, Geetika Garg, Sandeep Singh, Syed Ibrahim Rizvi
Erythrocytes are particularly vulnerable towards age-dependent oxidative stress mediated damage. Caloric restriction mimetics (CRMs) may provide a novel strategy for the maintenance of redox balance as well as effective treatment of age associated diseases. Herein, we have investigated the beneficial effect of co-treatment of CRM-candidate drugs, rapamycin (an immunosuppressant drug and inhibitor of mammalian target of rapamycin) and metformin (an anti-diabetic biguanide and activator of adenosine monophosphate kinase) against aging-induced oxidative stress in erythrocytes and plasma of aging rats...
May 17, 2017: Rejuvenation Research
https://www.readbyqxmd.com/read/28514190/criterion-referenced-fitness-standards-associated-with-maintaining-functional-capacity-in-chilean-older-adults
#17
Eugenio Merellano-Navarro, Daniel Collado-Mateo, Javier García-Rubio, Narcís Gusi, Pedro R Olivares
The aim of the current study was to develop fitness standards associated with maintaining physical capacity in older adults at two different levels - that needed for advanced functioning and that needed for maintaining moderate (independent) functional ability. Cross-sectional study of 406 Chilean adults aged 60 and more. Functional capacity was measured via the Composite Physical Function scale (CPF). A battery of validated fitness tests for this population was used. Based on the results of the CPF, two variables were created: "advanced physical capacity" (defined as those scoring 24 on the CPF scale) and "moderate (independent) physical capacity," defined as those scoring between 14 and 23 on the CPF scale...
May 17, 2017: Rejuvenation Research
https://www.readbyqxmd.com/read/28398133/combined-effect-of-obesity-and-mobility-limitation-with-incidence-of-type-2-diabetes-and-mortality-in-chinese-elderly
#18
Li Kang, Liye Jia, Peipei Han, Wen Zhang, Yixuan Ma, Liyuan Fu, Hairui Yu, Xiaoyu Chen, Lu Wang, Lin Hou, Xing Yu, Jianing Song, Ruiming He, Hui Li, Tingting Miao, Xiaolong Yang, Kaijun Niu, Liancheng Wang, Qi Guo
This article aims to examine the effect of mobility limitation and obesity on the risk of new incidence of type 2 diabetes mellitus (T2DM) and mortality. The design was a cohort study (n = 1075) among adults aged 60 years and older. Obesity was defined as body-mass index greater than or equal to 28 kg/m(2). Mobility limitation was defined as participants scoring in the top 20% on the timed up and go test or in the slowest 20% for the 4-m walking test. The mean age of the study population was 67.4 ± 5...
May 17, 2017: Rejuvenation Research
https://www.readbyqxmd.com/read/28498065/effect-of-interval-and-continuous-aerobic-training-on-basal-serum-and-plasma-bdnf-values-in-seniors-a-systematic-review-of-intervention-studies
#19
Lievyn Enette, Thomas Vogel, Jean Luc Fanon, Pierre Olivier Lang
The purpose of this systematic review was to provide a comprehensive analysis of the available clinical trials analyzing, in seniors, the effect of aerobic interval training (IAT) and continuous aerobic training (CAT) on peripheral Brain-derived neurotropic factor (BDNF) concentration. We identified 14 randomized or not-randomized intervention studies published up to January 2017 through a computer-assisted search (PUBMED, Pedro, and Science direct data bases). The 5 trials considering IAT and the 9 CAT totalized 988 individuals (age range: 58...
May 12, 2017: Rejuvenation Research
https://www.readbyqxmd.com/read/28498017/dietary-supplements-as-surrogate-of-mediterranean-diet-in-healthy-smoking-subjects
#20
Sonya Vasto, Giulia Accardi, Anna Aiello, Francesca Di Gaudio, Annalisa Barera, Serena Indelicato, Damiano Galimberti, Emilio Italiano, Roberto Monastero, Claudia Rizzo, Calogero Caruso, Giuseppina Candore
The interventions to slow ageing, favouring active life expectancy, represent the new perspectives in ageing investigation. Some mechanisms that delay or prevent the onset of ageing pathologies have been identified. Between them, a healthy lifestyle seems to reduce many risk factors. In particular, eating habits represent the most concrete, low cost way to act on ageing process. Mediterranean diet has received much attention since it has been consistently demonstrated its anti-oxidant and anti-inflammatory effects...
May 12, 2017: Rejuvenation Research
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