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Rejuvenation Research

Guangchao Zhao, Lujia Yang, Shiquan Wang, Min Cai, Sisi Sun, Hailong Dong, Lize Xiong
It is known that preconditional treatment with volatile anesthetics can induce tolerance of the brain to stroke. A previous study demonstrated that the involvement of TREK-1, a two-pore domain K+ channel, in sevoflurane preconditioning-induced neuroprotection against focal cerebral ischemia in rats. The present study testified whether TREK-2, another anesthetics-target K+ channels, is also associated with volatile anesthetics-induced neuroprotection, and further explored its potential mechanism. METHODS: Rats preconditioned with isoflurane were subjected to 1...
November 9, 2018: Rejuvenation Research
Wenting Duan, Lin Wang, Jianzhuang Lv, Kai Gao, Yiqing Lu, Shaobo Qin, Xin Ma, Jiankang Li, Xingli Ge
Salviae miltiorrliza-borneol Jun-Shi coupled-herbs have been widely used for treatment of ischemia stroke. Salvianolic acid B was the most abundant and bioactive compound of Salviae miltiorrliza and used for prevention and treatment of cerebrovascular diseases. However, the scientific intension and compatible mechanism of Salvianolic acid B - borneol combination were still unknown. A metabolomics study approach based on UPLC-Q/TOF-MS combined with a pathological study has been applied to study the metabolic disturbances of cerebral ischemia and evaluate the efficacies of Sal B and Sal B/ borneol against cerebral ischemia in MCAO rats...
November 9, 2018: Rejuvenation Research
Peter Rohdewald
Extension of the healthy life span is of primary importance for the aging society. Among exercise, healthy nutrition, and mental training, food supplements are widely used as preventive measures to postpone the diverse symptoms of aging. The extract from the bark of the French maritime pine, Pycnogenol, rich on flavonoids, has anti-inflammatory and antioxidative property, proven in in vivo studies. The extract reduces oxidative stress and improves endothelial health. Its antithrombotic properties are based on inhibition of platelet aggregation...
November 7, 2018: Rejuvenation Research
Ya Sun, Guangzhao Qi, Duolu Li, Haiyang Meng, Zhenfeng Zhu, Yongmei Zhao, Yuedong Qi, Xiaojian Zhang
Walnuts kernels (Juglans regia L.) have rich antioxidants content and have been used in both cosmetic and pharmaceutical industry. The current study dealt with the protective role of walnut kernels extracts (WK) on isoproterenol (ISO)-induced myocardial infarction (MI) in rats. Rats were pretreated with WK extracts (300 mg/kg) daily for 35 days. Then, isoproterenol (100 mg/kg) was injected subcutaneously into rats to induce myocardial infarction. Cardiac diagnostic markers (LDH and CPK), cardiac troponin, heart lipid peroxidation (TBARS and hydroperoxide), antioxidant system (CAT, SOD, GPx, GST, GSH and GSSG) and the levels of lipid profile were evaluated in rats, and the results revealed WK significantly prevented myocardial injury induced by ISO (P<0...
November 6, 2018: Rejuvenation Research
Alberto Pilotto, Nicola Veronese, Katerin Quispe, Sabrina Zora, An Boone, Matteo Puntoni, Angela Giorgeschi, Alberto Cella, Inès Hidalgo, Yves-Marie Pers, Alberto Ferri, Hevia Fernandez, Marta Pisano Gonzalez
The Multidimensional Prognostic Index (MPI) is a Comprehensive Geriatric Assessment (CGA)-based tool that accurately predicts negative health outcomes in older subjects with different diseases and settings. To calculate the MPI several validated tools are assessed by health care professionals according to the CGA, whilst self-reported information by the patients is not available, but it could be of importance for the early identification of frailty. We aimed to develop and validate a self-administered MPI (SELFY-MPI) in community-dwelling subjects...
November 1, 2018: Rejuvenation Research
Yahui Ding, Zhiyang Zhang, Zhongbao Yue, LiuGang Ding, Yong Zhou, Zebo Huang, Hongliang Huang
Liver cells are easy to be damaged by oxidative stress during the progression both liver development and throughout adult life, resulting in tissue pathology which ranges from simple hepatitis to non-alcoholic fatty liver disease (NAFLD). Here, we determined the attenuation of oxidative stress on liver cells with pre-treatment of Rosmarinic acid (RA), which is an antioxidant agent from Rosmarinus officinalis. Human liver cell line L02 was damaged by hydrogen peroxide (H2O2). In the RA treatment group, the viability of L02 cells increased and the intracellular reactive oxygen species (ROS) levels decreased compared with the H2O2-induced damage group...
October 31, 2018: Rejuvenation Research
Chun-Feng Liu, Xiao-Lin Li, Zi-Long Zhang, Lu Qiu, Shi-Xuan Ding, Jun-Xin Xue, Guo-Ping Zhao, Jian Li
Although the health benefits attributed to urolithin A, such as anticancer, anti-inflammatory, and antioxidant effects, are based on numerous, diverse studies carried out in vitro, the biological effects of urolith A are still not entirely understood. In this study, we explored the biological effects of urolithin A using senescent human skin fibroblasts (HSFs) to determine whether urolithin A has any antiaging potential. Our results showed that urolithin A significantly increased type I collagen expression and reduced matrix metalloproteinase 1 (MMP-1) expression...
October 25, 2018: Rejuvenation Research
Ludmila Yarmolinsky, Arie Budovsky, Shimon Ben-Shabat, Boris Khalfin, Jonathan Gorelick, Yael Bishitz, Rachel Miloslavski, Leonid Yarmolinsky
Crude ethanolic extract from Phlomis viscosa Poiret leaves from the Judea region (Israel) are renowned for their remarkable geroprotective properties: anti-inflammatory, anti-diabetic, and anti-cancer. A phytochemical investigation carried out in present study revealed that the tested plant might belong to a particular distinct chemotype because its phytochemicals are different from compounds which were mentioned in the literature. Among the compounds identified by us was diosmin, which synthetic derivatives were further obtained and investigated...
October 24, 2018: Rejuvenation Research
Fang Dou, YueTong Liu, Limin Liu, Jingwen Wang, Ting Sun, Fei Mu, Qiyan Guo, Chao Guo, Na Jia, Wenxin Liu, Yi Ding, Aidong Wen
Fibrosis is the major pathological feature of chronic kidney disease (CKD). Aloe-emodin (AE), one of the main active compounds in Rhubarb, is widely used for renal protection. However, mechanisms implied in the modulation of kidney fibrosis after AE treatment for CKD remain elusive. Here, we explored the protective effects of AE for renal fibrosis and the involved mechanisms in vivo and in vitro. The renal fibrosis mice model was established by unilateral ureteral obstruction (UUO). We found that AE administration significantly ameliorated UUO-induced impairment of kidney, evidenced by improved histopathological abnormalities, body weight, and abnormal renal function in mice model...
October 24, 2018: Rejuvenation Research
Josh Mitteldorf
Recent advances in technology of "aging clocks" based on DNA methylation suggest that it may be possible to measure changes in the rate of human aging over periods as short as a year or two. To the extent that methylation is a valid surrogate for biological age, testing of anti-aging interventions has become radically cheaper and faster. Together with colleagues at UCLA and UCSD, I have initiated a clinical trial to evaluate some of the most popular anti-aging strategies currently deployed by "early adopters" in the lay community of personal health activists...
October 21, 2018: Rejuvenation Research
Samuel L Buckner, Scott J Dankel, Zachary W Bell, Takashi Abe, Jeremy P Loenneke
The relationship between grip strength and mortality is often used to underscore the importance of resistance exercise in physical activity guidelines. However, grip strength does not appear to appreciably change following traditional resistance training. Thus, grip strength could be considered reflective of strength independent of resistance exercise. If true, grip strength is not necessarily informing us of the importance of resistance exercise as an adult, but potentially highlighting inherent differences between individuals who are stronger at "baseline" compared to their weaker counterpart...
October 18, 2018: Rejuvenation Research
Colin Farrelly
In this article, I argue that senescence (biological aging) is one of the greatest threats to human freedom in the 21st century. The two most prominent conceptions of freedom are "negative" and "positive" liberty. The negative conception of liberty equates freedom with the absence of interference, whereas the positive conception equates freedom with having the capacity to be self-determining. By critically examining both the negative and positive conceptions of liberty, I make the case that senescence does violate our liberty, on both accounts of freedom...
October 18, 2018: Rejuvenation Research
Svetlana Zalomonson, Tamar Freud, Boris Punchik, Tali Samson, Svetlana Lebedinsky, Yan Press
AIM: Studies of the effect of aromatherapy on patients with behavioral and psychological symptoms of dementia (BPSD) have yielded contradictory results. One possible explanation for this lack of consistent results is the site of application of the oil. The aim of the study was to evaluate the effect of lavender oil on the rate of BPSD when applied close to and away from the olfactory system. METHODS: A cross-over placebo-controlled study was conducted in the two psychogeriatric LTC departments...
October 17, 2018: Rejuvenation Research
Donatella Poz, Elena De Falco, Calogera Pisano, Rosalinda Madonna, Peter Ferdinandy, Carmela Rita Balistreri
Evidence suggests association of red blood cell distribution width (RDW) with cardiovascular diseases (CVDs). On the contrary, we underline that the sole RDW values cannot represent a valid CVD biomarker. High RDW values are expression of biological effects of a lot of both endogenous and exogenous factors (i.e., age, sex, genetic background, inflammation, hormones, drugs, diet, exercise, hematological analyzers, and ranges of values), modulating the biology and physiology of erythrocytes. Thus, the singular monitoring of RDW cannot be used to predict cardiovascular disorders...
October 13, 2018: Rejuvenation Research
Kiana Rafiepour, Saeed Esmaeili-Mahani, Ali Salehzadeh, Vahid Sheibani
Parkinson's disease (PD) is a destroying and prevalent neurodegenerative disease that is characterized by a progressive death of midbrain dopaminergic neurons. It is important to understand the possible neuroprotective effects of reagents that rescue the neurons from death and apoptosis. In this study, we investigated the effects of abscisic acid (ABA) on 6-hydroxydopamine (6-OHDA)-induced neurotoxicity in human dopaminergic neuroblastoma SH-SY5Y cell line as an in vitro model of PD. Cell damage was induced by 150 μM 6-OHDA and the cell viability was examined by 2-[4,5-dimethyl-2-thiazolyl]-2,5-diphenyl-2-tetrazolium bromide (MTT) assay...
October 6, 2018: Rejuvenation Research
Sha Zhang, Jie Li, Pei Xie, Ting Zang, Haibin Shen, Guochun Cao, Ying Zhu, Zhenggang Yue, Zhe Li
Chronic inflammation is a major driving factor for the development of colitis-associated cancer (CAC). It is extensively acknowledged that patients who have long-standing inflammation bowel disease are at high risk for developing CAC. However, the metabolic alteration by which chronic intestinal inflammation promotes colorectal cancer is unclear. In the present study, we constructed dextran sulfate sodium (DSS)-induced colitis mouse model to uncover possible alterations in the metabolism indexes. Interestingly, after DSS diet administration, the expression of metabolism indexes and c-Myc increased...
September 4, 2018: Rejuvenation Research
Kuldeep Nigam, Atinderpal Kaur, Kailash Manda, Amit Tyagi, Reema Gabrani, Shweta Dang
In the present work, PLGA nanoparticles of baclofen (Bcf-PLGA-NPs) were developed and optimized using nanoprecipitation method. The average particle size of the Bcf-PLGA-NP was found to be 124.8 nm, polydispersity index of 0.225 and zeta potential was found to be in the range of -20.4 mV. In-Vitro dissolution studies showed that baclofen was released from PLGA NPs in a sustained fashion from 50 % release in 2.5 hrs to 80-85% in 24 hrs. MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) assay on Neuro-2a neuroblastoma cell line showed comparably low cytotoxicity of Bcf-PLGA-NPs as compared to aqueous solution of Baclofen at reported Cmax values of the drug 737...
September 3, 2018: Rejuvenation Research
Bo Zhang, Yan Li, Jia-Wei Liu, Xue-Wei Liu, Wei Wen, Yu Cui, Shu-Ming Huang
Kaixin-San (KXS), a Chinese formula, was used to treat "amnesia," a senile dementia in the modern world. This formula was reported to improve behavioral performances in many animal models. This study was designed to explore how KXS has improved amyloid-β (Aβ)-induced memory dysfunction in mice. The mouse models were achieved through unilateral ventricle injection with Aβ42 . The effects of KXS on memory improvement were evaluated by the step-down test. The electrophysiological changes induced by KXS were measured by long-term potentiation (LTP) analysis in the hippocampus in vivo...
August 29, 2018: Rejuvenation Research
Alison Carter, Edward Meinert, David Brindley
Based on experience and the existing limited research literature in biotechnology corporate governance, the authors propose potential attributes of minimum corporate governance standards for biotechnology companies, as a basis for further quantitative and qualitative research. The authors assert that the recent proliferation of biotechnology start-up organisations is substantively changing inter- and intra-organizational cultures throughout the healthcare sector via a 'cascade of governance'. Therefore, governance decisions and actions - both positive and negative - that are instituted in start-up biotech companies may set new norms for other start-up biotech companies, the larger (bio)pharmaceutical companies by which they are acquired and the range of healthcare sub-sector actors that interact with biotechnology companies...
August 24, 2018: Rejuvenation Research
Ginus Partadiredja, Nisa Karima, Kurnia Putri Utami, Denny Agustiningsih, Zaenal Muttaqien Sofro
Aging causes the degeneration of organs of the locomotor system, including the cerebellum and bones. Exercise may reverse this deterioration. d-galactose has been frequently used in rodents to accelerate aging. The present study aimed at investigating the effects of exercise on cerebellar and serum growth factors, motor activity, and the number of bone cells of the femoral head of d-galactose-treated rats. Twenty-four male Wistar rats were divided randomly into four groups, that is, three treated groups injected with 300 mg/(mL·kg) body weight (bw) d-galactose solution daily for 4 weeks, and a control group injected with normal saline...
August 23, 2018: Rejuvenation Research
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