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Rejuvenation Research

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https://www.readbyqxmd.com/read/27796163/bioimpedance-derived-phase-angle-and-mortality-among-older-people
#1
Laurence Genton, Kristina Norman, Adrian Spoerri, Claude Pichard, Véronique L Karsegard, François R Herrmann, Christophe E Graf
BACKGROUND: Phase angle measured by bioelectrical impedance analysis (BIA) may be a marker of health state. OBJECTIVE: This historical cohort study of prospectively collected BIA measurements aims to investigate the link between phase angle and mortality in older people and evaluate whether a phase angle cutoff can be defined. DESIGN: We included all adults aged ≥65 years who underwent a BIA measurement by the Nutriguard(®) device at the Geneva University Hospitals...
December 2, 2016: Rejuvenation Research
https://www.readbyqxmd.com/read/27897089/anti-aging-effect-of-metformin-on-brain-in-naturally-aged-and-accelerated-senescence-model-of-rat
#2
Geetika Garg, Sandeep Singh, Abhishek Kumar Singh, Syed Ibrahim Rizvi
Metformin, a biguanide, is a widely used anti-diabetic drug which inhibits gluconeogenesis and is used to treat hyperglycemia in type 2 diabetes. Through activation of AMPK pathway, metformin also mimics caloric restriction health benefits. Aging causes substantial molecular to morphological changes in brain, the brain cells being more susceptible towards oxidative stress mediated damages due to the presence of high lipid content and higher oxygen consumption. Wistar rats (naturally aged and D Galactose induced rat model) were supplemented with metformin (300 mg/kg b...
November 29, 2016: Rejuvenation Research
https://www.readbyqxmd.com/read/27881050/pharmaceutical-rejuvenation-of-age-associated-decline-in-spatial-memory
#3
Andrew R Mendelsohn, James Larrick
Spatial memory and cognition decline during aging. Montelukast, an FDA approved drug for the treatment of asthma can restore spatial memory in old rats to levels similar to those of young animals. Treatment improves three hallmarks of aging in the brain: reducing microglial- mediated neuroinflammation, brain blood barrier permeability and increasing neurogenesis in the hippocampus although not completely to youthful levels.  Other aging-associated parameters, such as reduced synaptic density, are not affected, suggesting that anti-aging therapeutics may be further optimized...
November 23, 2016: Rejuvenation Research
https://www.readbyqxmd.com/read/27869539/meetings-calendar
#4
Aubrey D N J de Grey
n/a.
November 21, 2016: Rejuvenation Research
https://www.readbyqxmd.com/read/27869535/serum-thyroid-stimulating-hormone-levelsand-frailty-in-the-elderly-the-pro-v-a-study
#5
Nicola Veronese, Sara Watutantrige, Stefania Maggi, Marianna Noale, Brendon Stubbs, Raffaele Antonelli Incalzi, Sabina Zambon, Maria Chiara Corti, Egle Perissinotto, Gaetano Crepaldi, Enzo Manzato, Giuseppe Sergi
High or low thyroid-stimulating hormone (TSH) levels seem to be associated with several negative outcomes in the elderly, but the literature about TSH and frailty is still limited. In this paper, we investigated whether TSH is associated with prevalent and incident frailty in a cohort of older community-dwelling subjects. Among 3,099 initially screened in the Progetto Veneto Anziani Study, 2,571 men and women aged >65 years (for cross-sectional analyses) and 1,732 (longitudinal, mean follow-up period of 4...
November 21, 2016: Rejuvenation Research
https://www.readbyqxmd.com/read/27869533/commentary-on-some-recent-theses-relevant-to-combating-aging-december-2016
#6
Benjamin Zealley, Aubrey D N J de Grey
n/a.
November 21, 2016: Rejuvenation Research
https://www.readbyqxmd.com/read/27841739/age-related-reduction-of-contractile-responses-to-urotensin-ii-is-seen-in-aortas-from-wistar-rats-but-not-from-type-2-diabetic-goto-kakizaki-rats
#7
Takayuki Matsumoto, Shun Watanabe, Shota Kobayashi, Makoto Ando, Kumiko Taguchi, Tsuneo Kobayashi
Vascular dysfunction is a common finding in type 2 diabetes, although the response to urotensin II (UII), a potent vasoconstrictor peptide, remains unclear. We investigated whether a UII-induced contraction was increased in the aortas from type 2 diabetic Goto-Kakizaki (GK) rats at the chronic stage. At 36 or 37 weeks of age (older group), a UII-induced contraction was seen in GK rats and was reduced by a Rho kinase inhibitor or urotensin receptor (UT) antagonist, whereas UII failed to induce a contraction in aortas from age-matched Wistar rats...
November 14, 2016: Rejuvenation Research
https://www.readbyqxmd.com/read/27814668/orexin-a-protects-human-neuroblastoma-sh-sy5y-cells-against-6-ohda-induced-neurotoxicity-involvement-of-pkc-and-pi3k-signaling-pathways
#8
Hamzeh Pasban-Aliabadi, Saeed Esmaeili-Mahani, Mehdi Abbasnejad
Parkinson's disease (PD) is a common neurodegenerative disorder characterized by progressive and selective death of dopaminergic neurons. Multifunctional neuropeptide orexin-A is involved in many biological events of the body. It has been shown that orexin-A has protective effects in neurodegenerative disease such as PD. However, its cellular mechanisms have not yet been fully clarified. Here, we investigated the intracellular signaling pathway of orexin-A neuroprotection in 6-OHDA-induced SH-SY5H cells damage as an in vitro model of PD...
November 4, 2016: Rejuvenation Research
https://www.readbyqxmd.com/read/27733078/careless-skeptics-a-dangerous-breed
#9
Aubrey D N J de Grey
n/a.
October 12, 2016: Rejuvenation Research
https://www.readbyqxmd.com/read/27630032/commentary-on-some-recent-theses-relevant-to-combating-aging-october-2016
#10
Benjamin Zealley, Aubrey D N J de Grey
No abstract text is available yet for this article.
October 11, 2016: Rejuvenation Research
https://www.readbyqxmd.com/read/27612523/reversal-of-aged-muscle-stem-cell-dysfunction
#11
James W Larrick, Jasmine W Larrick, Andrew R Mendelsohn
The loss of muscle stem cell (MuSC) numbers and function in the elderly results in a dramatic delay or incomplete repair of muscle following injury or surgery. Prolonged immobility can exacerbate the loss of muscle mass with increased morbidity of affected patients. Stem cells and their niche cooperate to regulate the activation, self-renewal, differentiation, and return to quiescence of MuSCs. Extracellular matrix fibronectin (FN) and MuSC β1-integrin have been identified as critical factors in the dysfunction of aging muscle...
October 11, 2016: Rejuvenation Research
https://www.readbyqxmd.com/read/27651115/urinary-incontinence-and-its-association-with-frailty-among-men-aged-80-years-and-older-in-taiwan-a-cross-sectional-study
#12
Chih-Jen Wang, Cheng-Hao Hung, Ting-Ching Tang, Liang-Yu Chen, Li-Ning Peng, Fei-Yuan Hsiao, Liang-Kung Chen
AIMS: To evaluate the prevalence of urinary incontinence (UI) and its association with frailty among men aged 80 years and older in Taiwan METHODS: Residents living in four veterans retirement communities were invited for study and 440 men aged 80 years and older weer enrolled. Comprehensive geriatric assessment was performed for them, including using the following measurements: Clinical Frailty Scale, Northern Health and Social Care Trust (HSC)-Continence Assessment Form, Charlson's Comorbidity Index (CCI), Barthel Index (BI), Instrumental Activities of Daily Living (IADL), Mini-Mental State Examination (MMSE), Geriatric Depression Scale-5 (GDS-5), Mini-Nutritional Assessment-Short Form (MNA-SF)...
September 21, 2016: Rejuvenation Research
https://www.readbyqxmd.com/read/27629908/meetings-calendar
#13
Aubrey D N J de Grey
No abstract text is available yet for this article.
September 14, 2016: Rejuvenation Research
https://www.readbyqxmd.com/read/27392574/the-three-false-dawns-of-biomedical-gerontology
#14
Aubrey D N J de Grey
No abstract text is available yet for this article.
August 2016: Rejuvenation Research
https://www.readbyqxmd.com/read/27392531/-not-available
#15
(no author information available yet)
No abstract text is available yet for this article.
August 2016: Rejuvenation Research
https://www.readbyqxmd.com/read/27378359/uncoupling-mitochondrial-respiration-for-diabesity
#16
James W Larrick, Jasmine W Larrick, Andrew R Mendelsohn
Until recently, the mechanism of adaptive thermogenesis was ascribed to the expression of uncoupling protein 1 (UCP1) in brown and beige adipocytes. UCP1 is known to catalyze a proton leak of the inner mitochondrial membrane, resulting in uncoupled oxidative metabolism with no production of adenosine triphosphate and increased energy expenditure. Thus increasing brown and beige adipose tissue with augmented UCP1 expression is a viable target for obesity-related disorders. Recent work demonstrates an UCP1-independent pathway to uncouple mitochondrial respiration...
August 2016: Rejuvenation Research
https://www.readbyqxmd.com/read/26918466/dietary-luteolin-reduces-proinflammatory-microglia-in-the-brain-of-senescent-mice
#17
Michael D Burton, Jennifer L Rytych, Ravi Amin, Rodney W Johnson
Brain microglia become dysregulated during aging and express proinflammatory cytokines that play a role in cognitive aging. Recent studies suggest the flavonoid luteolin reduces neuroinflammation and improves learning and memory in aged mice. However, if dietary luteolin reduces microglia activity in the brain of senescent mice is not known. We hypothesized that feeding aged mice a diet with luteolin would reduce microglia activity. Adult (3-6 months) and aged (22-24 months) mice were fed American Institute of Nutrition (AIN)-93M or AIN-93M with luteolin (6 g/kg) for 4 weeks and injected intraperitoneally with saline or lipopolysaccharide (LPS) before microglia were isolated and stained for major histocompatibility complex (MHC) class II, interleukin (IL)-1β, and IL-6 for flow cytometry...
August 2016: Rejuvenation Research
https://www.readbyqxmd.com/read/26650547/racemized-and-isomerized-proteins-in-aging-rat-teeth-and-eye-lens
#18
Rebeccah A Warmack, Eduardo Mansilla, Rodolfo G Goya, Steven G Clarke
The quantification of aspartic acid racemization in the proteins of nonmetabolically active tissues can be used as a measure of chronological aging in humans and other long-lived organisms. However, very few studies have been conducted in shorter-lived animals such as rodents, which are increasingly used as genetic and metabolic models of aging. An initial study had reported significant changes in the ratio of d- to l-aspartate in rat molars with age. Using a sensitive HPLC method for the determination of d- and l-aspartate from protein hydrolysates, we found no accumulation of d-aspartate in the molars of 17 rats that ranged in age from 2 to 44 months, and the amount of d-aspartate per molar did not correspond with molar eruption date as had been previously reported...
August 2016: Rejuvenation Research
https://www.readbyqxmd.com/read/26650400/a-rat-treated-with-mesenchymal-stem-cells-lives-to-44-months-of-age
#19
Eduardo Mansilla, Gustavo Roque, Yolanda E Sosa, Adrian Tarditti, Rodolfo G Goya
There is a growing interest in the potential of mesenchymal stem cells (MSCs) for implementing regenerative medicine. We assessed the effect of intravenous administration of human bone marrow-derived MSC on the life span of a single Sprague-Dawley female rat. The treatment was started when the rat was 6 months old and the cells were administered every 2 weeks afterward. The treatment did not induce any obvious changes in body growth or behavior and the rat showed the typical age changes for this strain, except that, unlike intact counterparts, the animal did not develop mammary tumors or pituitary gland hyperplasia...
August 2016: Rejuvenation Research
https://www.readbyqxmd.com/read/26649945/whole-body-induced-cell-turnover-a-proposed-intervention-for-age-related-damage-and-associated-pathology
#20
Francesco Albert Bosco Cortese, Giovanni Santostasi
In both biomedicine in general and biomedical gerontology in particular, cell replacement therapy is traditionally proposed as an intervention for cell loss. This article presents a proposed intervention-whole-body induced cell turnover (WICT)-for use in biomedical gerontology that combines cell replacement therapy with a second therapeutic component (targeted cell ablation) so as to broaden the therapeutic utility of cell therapies and increase the categories of age-related damage that are amenable to cell-based interventions...
August 2016: Rejuvenation Research
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