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Rejuvenation Research

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https://www.readbyqxmd.com/read/29781380/finally-a-regimen-to-extend-human-life-expectancy
#1
James Larrick, Andrew R Mendelsohn
The US has the most expensive healthcare system worldwide. Yet measures of healthspan and life expectancy are well below the major industrialized nations. With the US population aged 65 and older projected to double by mid-century a healthcare crisis is looming. Within this context huge interest and investment has emerged in technologies and drugs to address aging with an expected benefit to healthspan. The thesis being that such basic interventions will reduce morbidity caused by many chronic diseases where biological age itself is the major risk factor...
May 21, 2018: Rejuvenation Research
https://www.readbyqxmd.com/read/29756514/ilex-paraguariensis-extends-lifespan-and-increases-an-ability-to-resist-environmental-stresses-in-drosophila
#2
Prakshit Niraula, Saurav Ghimire, Hanna Lee, Man Su Kim
Aging is a complex process resulting in: i) a decline in body functions and capacity to withstand environmental stress and ii) an increased susceptibility to diseases including, but not limited to, cardiovascular disorders, diabetes, cancer and dementia. Among a number of herbal products used to alleviate symptoms associated with aging is Ilex paraguariensis (IP). This product has been reported to have anticancer, anti-inflammatory and antioxidant activities. However, its effect on an organisms' longevity has not been thoroughly studied to date...
May 14, 2018: Rejuvenation Research
https://www.readbyqxmd.com/read/29717617/selegiline-nanoformulation-in-attenuation-of-oxidative-stress-and-upregulation-of-dopamine-in-the-brain-for-the-treatment-of-parkinson-s-disease
#3
Shobhit Kumar, Shweta Dang, Kuldeep Nigam, Javed Ali, Sanjula Baboota
Objective of the present study was to determine whether the prepared nanoemulsion would be able to deliver selegiline to the brain by intranasal route improving its bioavailability. Antioxidant activity, pharmacokinetic parameters and dopamine concentration were determined. Oxidative stress models which had Parkinson's disease like symptoms were used to evaluate the antioxidant activity of nanoemulsion loaded with selegiline in vivo. The antioxidant activity was evaluated by 1,1-diphenyl-2-picryl-hydrazyl (DPPH) assay and reducing power assay which showed high scavenging efficiency for selegiline nanoemulsion compared to pure selegiline...
May 2, 2018: Rejuvenation Research
https://www.readbyqxmd.com/read/29695187/restoring-nad-levels-with-nad-intermediates-the-second-law-of-thermodynamics-and-aging-delay
#4
Borut Poljsak, Irina Milisav
The hypothesis regarding the role of increased nicotinamide adenine dinucleotide (NAD+) levels with reference to the fundamental concepts of ageing and entropy is presented. Considering the second law of thermodynamics, NAD+ seems the appropriate candidate for reversing many aging-associated pathologies. NAD+ is presented as an essential compound that enables organisms to stay highly organized and well-maintained, with a lower entropy state.
April 26, 2018: Rejuvenation Research
https://www.readbyqxmd.com/read/29669458/effects-of-dance-exergaming-on-depressive-symptoms-fear-of-falling-and-musculoskeletal-function-in-fallers-and-non-fallers-community-dewlling-older-women
#5
Elisângela Valevein Rodrigues, Luiza Herminia Gallo, Ana Tereza Bittencourt Guimarães, Jarbas Melo Filho, Bruna Cavon Luna, Anna Raquel Silveira Gomes
The aim of this study was to evaluate the effects of a pop dance exergaming protocol on fall risk factors-depressive symptoms, fear of falling and musculoskeletal function-in community-dwelling, older female fallers and non-fallers. There were 47 community-dwelling older women assigned to the Intervention Group [fallers (n=10, 69.8 ± 4.3 years); non-fallers (n = 12, 68.9 ± 3.3 years)] or the Control Group [fallers (n = 12, 73.6 ± 5.4 years); non-fallers (n = 13, 68.7 ± 4.8 years)]. The Control Group maintained their lifestyle and the Intervention Group performed a videogame dance training three times per week for 12 weeks...
April 19, 2018: Rejuvenation Research
https://www.readbyqxmd.com/read/29651925/heptamer-peptide-disassembles-native-amyloid-in-human-plasma-via-heat-shock-protein-70
#6
Timothy James Cunningham, Jeffrey I Greenstein, Lihua Yao, Itzhak Fischer, Theresa Conners
Proteostasis, which includes the repair and disposal of misfolded proteins, depends in part on the activity of heat shock proteins, a well-known class of chaperone molecules. When this process fails abnormally folded proteins may accumulate in cells, tissues, and blood. These species are a hallmark of protein aggregation diseases but also amass during aging, often in the absence of an identified clinical disorder. We report that a neuroprotective cyclic heptapeptide, CHEC-7, which has been applied systemically as a therapeutic in animal neurodegeneration models, disrupts such aggregates and inhibits amyloidogenesis when added in nanomolar concentrations to human plasma...
April 13, 2018: Rejuvenation Research
https://www.readbyqxmd.com/read/29644926/role-of-ligands-of-receptor-for-advanced-glycation-end-products-rage-in-peripheral-artery-disease
#7
Sho-Ichi Yamagishi, Takanori Matsui
Atherosclerotic cardiovascular disease, including peripheral artery disease (PAD) is more common and severe in diabetic patients compared with non-diabetic individuals. Indeed, diabetes is associated with the increased risk of limb amputation and all-cause mortality in patients with symptomatic PAD. Proteins and lipids are non-enzymatically modified by sugars, resulting in the formation and accumulation of advanced glycation end products (AGEs), whose process is accelerated under diabetic conditions, especially patients with a long duration of diabetes...
April 12, 2018: Rejuvenation Research
https://www.readbyqxmd.com/read/29644921/cognitive-frailty-and-its-association-with-all-cause-mortality-among-community-dwelling-older-adults-in-taiwan-results-from-i-lan-longitudinal-aging-study
#8
Li-Kuo Liu, Wei-Ju Lee, Yi-Hui Wu, An-Chun Hwang, Ming-Hsien Lin, Hiroyuki Shimada, Li-Ning Peng, Ching-Hui Loh, Hidenori Arai, Liang-Kung Chen
BACKGROUND: The definition of cognitive frailty and its prediction for adverse outcome of community-living older adults remains controversial. This study aims to evaluate the association between cognitive frailty and all-cause mortality among community-living older adults. METHODS: Data of the I-Lan Longitudinal Aging Study (ILAS) were retrieved for study. Frailty was defined by Fried's criteria, and a series of neuropsychological assessments, including the Mini-Mental State Examination (MMSE), Center for Epidemiology Studies-Depression (CES-D), the delay free recall in the Chinese Version Verbal Learning Test, the Boston Naming Test, the category (animal) Verbal Fluency Test, the Taylor Complex Figure Test, the digital backward and the Clock Drawing Test were performed...
April 12, 2018: Rejuvenation Research
https://www.readbyqxmd.com/read/29609486/you-can-t-fool-the-children-of-the-revolution
#9
Aubrey D N J de Grey
n/a.
April 2, 2018: Rejuvenation Research
https://www.readbyqxmd.com/read/29592535/commentary-on-some-recent-theses-relevant-to-combating-aging-april-2018
#10
Benjamin Zealley, Aubrey D N J de Grey
Theses reviewed in this issue include "An Intranasal GDNF Gene Therapy Approach for Treating Parkinson's Disease", "Controlling Depth of Cellular Quiescence By an Rb-E2F Network Switch", "Immunoregulation of the Central Response to Peripheral Nerve Injury: Motoneuron Survival and Relevance to ALS", and "Single-Cell Whole-Genome Sequencing Reveals Widespread Somatic Copy Number Variations in the Developing Cerebral Cortex".
March 28, 2018: Rejuvenation Research
https://www.readbyqxmd.com/read/29385909/wu-tou-decoction-inhibits-angiogenesis-in-experimental-arthritis-by-targeting-vegfr2-signaling-pathway
#11
Lianhua He, Chunfang Liu, Congcong Sun, Jingxia Wang, Kai Zhi, Danni Sun, Hui Wang, Qianqian Wang, Na Lin
Wu-tou decoction (WTD) is a classic traditional Chinese medicine formula and has been extensively used for the treatment of rheumatoid arthritis (RA). Previous reports indicate that WTD possesses anti-inflammatory and antinociceptive activities, and inhibits the development of arthritic joints and disease severity of collagen-induced arthritis (CIA) or adjuvant-induced rats; however, its action on angiogenesis of RA has not been clarified. This study aims to determine the anti-angiogenic activity of WTD in CIA rats and in various angiogenesis models...
March 19, 2018: Rejuvenation Research
https://www.readbyqxmd.com/read/29378470/prunella-vulgaris-l-exerts-a-protective-effect-against-extrinsic-aging-through-nf-%C3%AE%C2%BAb-mapks-ap-1-and-tgf-%C3%AE-smad-signaling-pathways-in-uvb-aged-normal-human-dermal-fibroblasts
#12
Mengyang Zhang, Eunson Hwang, Pei Lin, Wei Gao, Hien T T Ngo, Tae-Hoo Yi
Prunella vulgaris L., a well-known traditional Chinese herbal medicine, has anti-inflammatory and antioxidant activities. In the present study, the underlying molecular mechanisms of the protective effect of P. vulgaris extract (PVE) were investigated in UVB-irradiated normal human dermal fibroblasts (NHDFs). The mRNA expression of matrix metalloproteinases (MMPs), procollagen type I, and cytokines, such as interleukin-6 (IL-6) and tumor necrosis factor (TNF-α), was determined by reverse transcription-polymerase chain reaction...
March 12, 2018: Rejuvenation Research
https://www.readbyqxmd.com/read/29667924/telomerase-may-paradoxically-accelerate-aging-of-the-dna-methylome
#13
Andrew R Mendelsohn, James W Larrick
DNA methylation (DNAm) clocks such as the Horvath DNAm clock provide the most accurate biological determination of biological age relative to chronological age available today. However, there is little correlation between DNAm clocks, telomere-based aging clocks, and transcriptomic-based aging clocks. Recently, a genome-wide association study identified single-nucleotide polymorphism variants of TERT, the gene that encodes telomerase, as accelerating intrinsic aging in the Horvath DNAm clock. These same variants have been previously associated with long telomeres in leukocytes, suggesting that TERT acts paradoxically on telomere-associated aging and DNAm-associated aging...
April 2018: Rejuvenation Research
https://www.readbyqxmd.com/read/29620967/meetings-calendar-2018
#14
(no author information available yet)
No abstract text is available yet for this article.
April 2018: Rejuvenation Research
https://www.readbyqxmd.com/read/29461942/atp-synthase-a-target-for-dementia-and-aging
#15
James W Larrick, Jasmine W Larrick, Andrew R Mendelsohn
Advancing age is the biggest risk factor for development for the major life-threatening diseases in industrialized nations accounting for >90% of deaths. Alzheimer's dementia (AD) is among the most devastating. Currently approved therapies fail to slow progression of the disease, providing only modest improvements in memory. Recently reported work describes mechanistic studies of J147, a promising therapeutic molecule previously shown to rescue the severe cognitive deficits exhibited by aged, transgenic AD mice...
February 2018: Rejuvenation Research
https://www.readbyqxmd.com/read/29390945/validated-living-worldwide-supercentenarians-living-and-recently-deceased-february-2018
#16
Robert D Young
No abstract text is available yet for this article.
February 2018: Rejuvenation Research
https://www.readbyqxmd.com/read/29378482/longevity-escape-velocity-medicine-a-new-medical-specialty-for-longevity
#17
EDITORIAL
Oliver N Zolman
No abstract text is available yet for this article.
February 2018: Rejuvenation Research
https://www.readbyqxmd.com/read/29378475/commentary-on-some-recent-theses-relevant-to-combating-aging-february-2018
#18
Benjamin Zealley, Aubrey D N J de Grey
No abstract text is available yet for this article.
February 2018: Rejuvenation Research
https://www.readbyqxmd.com/read/29356600/correction-to-cryoprotectant-toxicity-facts-issues-and-questions-by-best-bp-rejuvenation-res-2015-18-5-422-436-doi-10-1089-rej-2014-1656
#19
(no author information available yet)
No abstract text is available yet for this article.
February 2018: Rejuvenation Research
https://www.readbyqxmd.com/read/28728538/effects-of-cataract-opacity-and-surgery-on-sleep-quality
#20
Aya Kokune-Takahashi, Masahiko Ayaki, Kazuo Tsubota, Kazuno Negishi
This study aimed to identify the type of cataract opacity associated with subjective sleep quality for cataract patients. A total of 180 consecutive patients (average age 74.2 years) underwent cataract surgery with implantation of an ultraviolet-blocking or blue light-blocking intraocular lens. The participants' subjective sleep quality was evaluated using the Pittsburgh sleep quality index (PSQI) before and at 2 months after surgery. Patients were divided into two groups for analysis: normal sleepers (preoperative PSQI ≤5) and poor sleepers (preoperative PSQI ≥6)...
February 2018: Rejuvenation Research
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