Yu-Hang Zhang, FeiMing Huang, JiaBo Li, WenFeng Shen, Lei Chen, KaiYan Feng, Tao Huang, Yu-Dong Cai
Protein-protein interactions (PPIs) involve the physical or functional contact between two or more proteins. Generally, proteins that can interact with each other always have special relationships. Some previous studies have reported that gene ontology (GO) terms are related to the determination of PPIs, suggesting the special patterns on the GO terms of proteins in PPIs. In this study, we explored the special GO term patterns on human PPIs, trying to uncover the underlying functional mechanism of PPIs. The experimental validated human PPIs were retrieved from STRING database, which were termed as positive samples...
March 4, 2024: Protein Journal