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Korean Journal of Hepatology

Jae-Jun Shim
No abstract text is available yet for this article.
March 2012: Korean Journal of Hepatology
Woo Jung Choi, Woo Kyoung Jeong, Yongsoo Kim, Jinoo Kim, Ju Yeon Pyo, Young Ha Oh
No abstract text is available yet for this article.
March 2012: Korean Journal of Hepatology
Jae Do Yang, Woo Sung Moon
No abstract text is available yet for this article.
March 2012: Korean Journal of Hepatology
Jung Ho Kim, Eul Sik Jung, Seok Hoo Jeong, Ju Seung Kim, Yang Suh Ku, Ki Baik Hahm, Ju Hyun Kim, Yeon Suk Kim
An 80-year-old woman with hilar cholangiocarcinoma was hospitalized due to sudden-onset abdominal pain. Computed tomography revealed hepatic necrosis accompanied with emphysematous change in the superior segment of the right liver (S7/S8), implying spontaneous rupture, based on the presence of perihepatic free air. Although urgent percutaneous drainage was performed, neither pus nor fluids were drained. These findings suggest emphysematous hepatitis with a hepatic mass. Despite the application of intensive care, the patient's condition deteriorated rapidly, and she died 3 days after admission to hospital...
March 2012: Korean Journal of Hepatology
Kyu Sik Jung, Kyeong Hye Park, Young Eun Chon, Sa Ra Lee, Young Nyun Park, Do Yun Lee, Jin Sil Seong, Jun Yong Park
Reports of metastatic hepatocellular carcinoma (HCC) without a primary liver tumor are rare. Here we present a case of isolated HCC that had metastasized to the pelvic bone without a primary focus. A 73-year-old man presented with severe back and right-leg pain. Radiological examinations, including computed tomography (CT) and magnetic resonance imaging (MRI), revealed a huge mass on the pelvic bone (13×10 cm). He underwent an incisional biopsy, and the results of the subsequent histological examination were consistent with metastatic hepatocellular carcinoma...
March 2012: Korean Journal of Hepatology
Jihyun An, Joo Ho Lee, Hyojeong Lee, Eunsil Yu, Dan Bi Lee, Ju Hyun Shim, Sunyoung Yoon, Yumi Lee, Soeun Park, Han Chu Lee
Hepatitis A virus (HAV) infections occur predominantly in children, and are usually self-limiting. However, 75-95% of the infections in adults are symptomatic (mostly with jaundice), with the illness symptoms usually persisting for a few weeks. Atypical manifestations include relapsing hepatitis, prolonged cholestasis, and complications involving renal injury. Drug rash with eosinophilia and systemic symptoms (DRESS) syndrome is a severe, drug-induced hypersensitivity reaction characterized by skin rash, fever, lymph-node enlargement, and internal organ involvement...
March 2012: Korean Journal of Hepatology
Hee Bok Chae, Mee Jin Kim, Eui Geun Seo, Yong Hyeok Choi, Hee Seung Lee, Joung Ho Han, Soon Man Yoon, Seon Mee Park, Sei Jin Youn
BACKGROUND/AIMS: Newly developed and potent antiviral agents suffer from the problem of drug resistance. Multidrug resistance is a major impediment in the treatment of patients with chronic hepatitis B (CHB). In line with American Association for the Study of Liver Diseases guidelines, adefovir dipivoxil (ADV) add-on therapy is recommended in the case of lamivudine resistance, while tenofovir disoproxil fumarate (TDF) is recommended for ADV or entecavir (ETV) resistance. TDF is currently not available in Korea...
March 2012: Korean Journal of Hepatology
Sun Kyung Jang, Gi Hong Choi, Junjeong Choi, Xiaoyuan Quan, Jeong Won Jang, Bo Hyun Kim, Guhung Jung, Young Min Park
BACKGROUND/AIMS: We aimed to determine the association between the co-expression patterns of Notch1, Snail, and p53 proteins (NSP) and the postoperative prognosis of hepatocellular carcinoma (HCC). METHODS: The immunoblot data for molecular expression (147 HCC/corresponding non-HCC tissues and 15 dysplastic nodules) and the sequencing data for p53 mutations (110 HCCs) were obtained from our previous study. Data analyses were restricted to cases with HCC differentiation grade III (n=47), due to its high p53 mutation rate...
March 2012: Korean Journal of Hepatology
Jong Jin Hyun, Yeon Seok Seo, Hyonggin An, Sun Young Yim, Min Ho Seo, Hye Sook Kim, Chang Ha Kim, Ji Hoon Kim, Bora Keum, Yong Sik Kim, Hyung Joon Yim, Hong Sik Lee, Soon Ho Um, Chang Duck Kim, Ho Sang Ryu
BACKGROUND/AIMS: The nonspecific clinical presentation of acute hepatitis A (AHA) mandates the detection of anti-hepatitis A virus IgM antibodies (IgM anti-HAV) in the serum for obtaining a definitive diagnosis. However, IgM anti-HAV might not be present during the early phase of the disease. The aim of this study was to determine the optimal time for repeating the IgM anti-HAV test (HAV test) in AHA patients with a negative initial test. METHODS: In total, 261 patients hospitalized with AHA were enrolled for this retrospective study...
March 2012: Korean Journal of Hepatology
Sang Seok Lee, Hyun Sung Shin, Hyung Joon Kim, Su Jin Lee, Hyun Suk Lee, Kyung Hee Hyun, Yong Hyun Kim, Byoung Woon Kwon, Jin Hyung Han, Hoon Choi, Bae Hwan Kim, Joon Hyuk Lee, Ha Yan Kang, Hyun Deok Shin, Il Han Song
BACKGROUND/AIMS: Hepatocellular carcinoma (HCC), which is the third most common cancer in Korea, has a very poor prognosis. However, only a few studies have performed a comprehensive survival-related analysis in all patients who were consecutively diagnosed and treated over a given period of time. The aim of this study was to determine the 5-year survival rate and its prognostic factors among HCC patients. METHODS: In total, 257 patients who were consecutively diagnosed with HCC between January 2000 and December 2003 were followed until death or until December 2008...
March 2012: Korean Journal of Hepatology
Yun Jung Kim, Byoung Kuk Jang, Eun Soo Kim, Kyung Sik Park, Kwang Bum Cho, Woo Jin Chung, Jae Seok Hwang
BACKGROUND/AIMS: The treatment for chronic hepatitis C (CHC) is removal of the virus in order to prevent progression to liver cirrhosis and hepatocellular carcinoma (HCC). Few data have been presented regarding the clinical significance of changes in the alanine aminotransferase (ALT) level in this context. We analyzed the patterns of changes in ALT level and investigated the relationship between the rapid normalization of ALT and sustained virologic response (SVR) after combined treatment with peginterferon and ribavirin...
March 2012: Korean Journal of Hepatology
Hyun Young Woo, Jun Mo Youn, Si Hyun Bae, Jeong Won Jang, Jung Hoon Cha, Hye Lim Kim, Ho Jong Chun, Byung Gil Choi, Jong Young Choi, Seoung Kew Yoon
BACKGROUND/AIMS: Low-dose metronomic chemotherapy involves the frequent administration of comparatively low doses of cytotoxic agents with no extended breaks, and it may be as efficient as and less toxic than the conventional maximum tolerated dose therapy. This study evaluated the feasibility and therapeutic efficacy of metronomic chemotherapy in patients with advanced hepatocellular carcinoma (HCC) with major portal vein thrombosis (PVT). METHODS: Thirty consecutive HCC patients with major PVT with or without extrahepatic metastasis were prospectively allocated to metronomic chemotherapy consisting of epirubicin being infused through the correct hepatic artery at a dose of 30 mg/body surface area (BSA) every 4 weeks, and cisplatin (15 mg/BSA) and 5-fluorouracil (50 mg/BSA) every week for 3 weeks, with intervening 1 week breaks...
March 2012: Korean Journal of Hepatology
Tae Yeob Kim
No abstract text is available yet for this article.
March 2012: Korean Journal of Hepatology
Dae Won Jun, Won Young Tak, Si Hyun Bae, Youn Jae Lee
Pegylated interferon and ribavirin combination therapy is accepted as the standard antiviral treatment for chronic hepatitis C regardless of HCV genotype. This combination therapy achieves higher response rates than previous therapy, but, nevertheless, a large proportion of patients suffer from treatment failure or adverse events. Recent clinical studies of viral kinetics during antiviral treatment have led to the introduction of response-guided therapy, the concept of 'customized therapy depending on viral response', which focuses on modulation of the treatment period depending on the viral response to create a sustained viral response without unnecessary medication and costs...
March 2012: Korean Journal of Hepatology
Ki Tae Suk, Soon Koo Baik, Jung Hwan Yoon, Jae Youn Cheong, Yong Han Paik, Chang Hyeong Lee, Young Seok Kim, Jin Woo Lee, Dong Joon Kim, Sung Won Cho, Seong Gyu Hwang, Joo Hyun Sohn, Moon Young Kim, Young Bae Kim, Jae Geun Kim, Yong Kyun Cho, Moon Seok Choi, Hyung Joon Kim, Hyun Woong Lee, Seung Up Kim, Ja Kyung Kim, Jin Young Choi, Dae Won Jun, Won Young Tak, Byung Seok Lee, Byoung Kuk Jang, Woo Jin Chung, Hong Soo Kim, Jae Young Jang, Soung Won Jeong, Sang Gyune Kim, Oh Sang Kwon, Young Kul Jung, Won Hyeok Choe, June Sung Lee, In Hee Kim, Jae Jun Shim, Gab Jin Cheon, Si Hyun Bae, Yeon Seok Seo, Dae Hee Choi, Se Jin Jang
No abstract text is available yet for this article.
March 2012: Korean Journal of Hepatology
Yong Moon Shin
Usual biliary hamartomatosis presents as numerous small, non-enhancing nodules in liver. However, in some cases, it can presents as a single solid or cystic mass with various contrast enhancement pattern.
December 2011: Korean Journal of Hepatology
Wonkyung Jung, Baek hui Kim
No abstract text is available yet for this article.
December 2011: Korean Journal of Hepatology
Hee Sup Kim, Sook Hyang Jeong, Je Hyuck Jang, Hyung Joon Myung, Jin Wook Kim, Soo Mee Bang, Sang Hoon Song, Haeryoung Kim, Hae Sun Yun
A 37-year-old male presented with fever and jaundice was diagnosed as hepatitis A complicated with progressive cholestasis and severe autoimmune hemolytic anemia. He was treated with high-dose prednisolone (1.5 mg/kg), and eventually recovered. His initial serum contained genotype IA hepatitis A virus (HAV), which was subsequently replaced by genotype IIIA HAV. Moreover, at the time of development of hemolytic anemia, he became positive for immunoglobulin M (IgM) anti-hepatitis E virus (HEV). We detected HAV antigens in the liver biopsy specimen, while we detected neither HEV antigen in the liver nor HEV RNA in his serum...
December 2011: Korean Journal of Hepatology
Jong In Yang, Jung Mook Kang, Hee Jin Byun, Go Eun Chung, Jeong Yoon Yim, Min Jung Park, Jeong Hoon Lee, Jung Hwan Yoon, Hyo Suk Lee
Facial nerve palsy due to temporal bone metastasis of hepatocellular carcinoma (HCC) has rarely been reported. We experienced a rare case of temporal bone metastasis of HCC that initially presented as facial nerve palsy and was diagnosed by surgical biopsy. This patient also discovered for the first time that he had chronic hepatitis B and C infections due to this facial nerve palsy. Radiation therapy greatly relieved the facial pain and facial nerve palsy. This report suggests that hepatologists should consider metastatic HCC as a rare but possible cause of new-onset cranial neuropathy in patients with chronic viral hepatitis...
December 2011: Korean Journal of Hepatology
Joo Ho Lee, Yung Sang Lee, Pyo Nyun Kim, Beom Hee Lee, Gu Whan Kim, Han Wook Yoo, Nae Yun Heo, Young Suk Lim, Han Chu Lee, Young Hwa Chung, Dong Jin Suh
This is a case report of a 68-year-old man with hepatocellular carcinoma (HCC) accompanied by hereditary hemorrhagic telangiectasia (HHT), also known as Osler-Weber-Rendu disease, and hepatic vascular malformation. HHT is an autosomal dominant disorder of the fibrovascular tissue that is characterized by recurrent epistaxis, mucocutaneous telangiectasias, and visceral arteriovenous malformations. HHT is caused by mutation of the genes involved in the signaling pathway of transforming growth factor-β, which plays an important role in the formation of vascular endothelia...
December 2011: Korean Journal of Hepatology
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