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https://www.readbyqxmd.com/read/29843524/5th-international-workshop-on-lung-health-poster-awards-winners-abstracts
#1
(no author information available yet)
No abstract text is available yet for this article.
May 29, 2018: COPD
https://www.readbyqxmd.com/read/29799297/physical-inactivity-functional-status-and-exercise-capacity-in-copd-patients-receiving-home-based-oxygen-therapy
#2
Camila Mazzarin, Demetria Kovelis, Samia Biazim, Fábio Pitta, Silvia Valderramas
Chronic obstructive pulmonary disease (COPD) has systemic consequences that lead to reduced physical activity in daily life (PADL). Little is known about PADL and its associations in individuals with COPD on home-based long-term oxygen therapy (LTOT). The objective of the study was to determine whether there is an association between severe physical inactivity and pulmonary function, fatigue, dyspnea, functional status and exercise capacity in individuals with COPD on home-based LTOT using electric oxygen concentrators and to investigate which of these variables could influence inactivity in these individuals...
May 25, 2018: COPD
https://www.readbyqxmd.com/read/29799289/bronchodilator-responses-in-respiratory-impedance-hyperinflation-and-gas-trapping-in-copd
#3
Stephen Milne, Christoph Hammans, Stella Watson, Claude S Farah, Cindy Thamrin, Gregory G King
Hyperinflation, gas trapping and their responses to long-acting bronchodilator are clinically important in COPD. The forced oscillation technique (FOT) measures of respiratory system resistance and reactance are sensitive markers of bronchodilator response in COPD. The relationships between changes in resistance and reactance, and changes in hyperinflation and gas trapping, following long-acting bronchodilator (LA-BD) have not been studied. 15 subjects with mild-moderate COPD underwent FOT, spirometry then body plethysmography, before and 2 hours after a single 150 microg dose of the LA-BD indacaterol...
May 25, 2018: COPD
https://www.readbyqxmd.com/read/29799285/rehabilitation-of-patients-with-coexisting-copd-and-heart-failure
#4
Michele Vitacca, Mara Paneroni
Chronic obstructive pulmonary disease (COPD) and chronic heart failure (CHF) frequently coexist, significantly reducing the patient's quality of life (QoL) and increasing morbidity, disability and mortality. For both diseases, a multidisciplinary disease-management approach offers the best outcomes and reduces hospital readmissions. In both conditions, muscle dysfunction may dramatically influence symptoms, exercise tolerance/performance, health status and healthcare costs. The present review describes muscular abnormalities and mechanisms underlying these alterations...
May 25, 2018: COPD
https://www.readbyqxmd.com/read/29799281/impact-of-chronic-obstructive-pulmonary-disease-on-cognitive-and-motor-performances-in-dual-task-walking
#5
Nelly Heraud, François Alexandre, Mathieu Gueugnon, Corentin Davy, Emilie Tremey, Nicolas Oliver, Alain Varray
When two tasks are performed simultaneously, they compete for attentional resources, resulting in a performance decrement in one or both tasks. Patients with attention disorders have a reduced ability to perform several tasks simultaneously (e.g., talking while walking), which increases the fall risk and frailty. This study assessed the cognitive and motor performances of patients with COPD and healthy controls within a dual-task walking paradigm. A subobjective was to assess the impact of a pulmonary rehabilitation program on the dual-task performances in COPD...
May 25, 2018: COPD
https://www.readbyqxmd.com/read/29746193/chronic-obstructive-pulmonary-disease-and-stroke
#6
Alexandru Corlateanu, Serghei Covantev, Alexander G Mathioudakis, Victor Botnaru, Mario Cazzola, Nikolaos Siafakas
Chronic obstructive pulmonary disease (COPD) is currently the fourth leading cause of death in the world and its incidence and prevalence is on the rise. It is evident that COPD is linked to cardiovascular disease. In the last years, several studies demonstrated that COPD may also be a risk factor for stroke, another major cause of death worldwide. Taking in consideration that COPD has multiple comorbidities it is hard to say whether COPD is an independent risk factor for stroke or it is due to confounding effect...
May 10, 2018: COPD
https://www.readbyqxmd.com/read/29733688/psychological-stress-lung-function-and-exacerbation-risk-in-copd-is-an-increase-of-cholinergic-tone-a-possible-link
#7
Gennaro Liccardi, Luigino Calzetta, Manlio Milanese, Antonello Salzillo, Filippo Manzi, Marta Ferrari, Paola Rogliani
at a glance: On the hypothesis that psychological distress might interfere with airway reactivity in patients suffering of mild to moderate COPD through a cholinergic-mediated-bronchial reflex.
May 7, 2018: COPD
https://www.readbyqxmd.com/read/29697285/grading-severity-of-productive-cough-based-on-symptoms-and-airflow-obstruction
#8
Rodrigo Vazquez Guillamet, Hans Petersen, Paula Meek, Akshay Sood, Yohannes Tesfaigzi
The binary approach to the diagnosis of Chronic Bronchitis (CB) is a major barrier to the study of the disease. We investigated whether severity of productive cough can be graded using symptoms and presence of fixed airflow obstruction (FAO), and whether the severity correlates with health status, exposures injurious to the lung, biomarkers of inflammation, and measures of airway wall thickening. Findings from a cross-sectional sample of 1,422 participants from the Lovelace Smokers Cohort (LSC) were validated in 4,488 participants from the COPDGene cohort (COPDGene)...
April 26, 2018: COPD
https://www.readbyqxmd.com/read/29697272/mortality-related-to-chronic-obstructive-pulmonary-disease-and-co-morbidities-in-the-united-states-a-multiple-causes-of-death-analysis
#9
Jennifer Obi, Alem Mehari, Richard Gillum
Chronic obstructive pulmonary disease (COPD) mortality based on the underlying cause of death (UCOD) underestimates disease burden. We aimed to determine the current COPD mortality rate, trends and the distribution of co-morbidities using United States (US) multiple-cause of death (MCOD) records. All 38,905,575 death certificates of decedents aged ≥45 years in the United States were analyzed for 1999-2015. COPD was defined by ICD-10 codes J40-J44 and J47 based either on the UCOD or up to 20 contributing causes coded...
April 26, 2018: COPD
https://www.readbyqxmd.com/read/29683758/asthma-copd-overlap-phenotypes-and-smoking-comparative-features-of-asthma-in-smoking-or-non-smoking-patients-with-an-incomplete-reversibility-of-airway-obstruction
#10
Louis-Philippe Boulet, Marie-Ève Boulay, Jude-Lyne Dérival, Joanne Milot, Johane Lepage, Lara Bilodeau, François Maltais
The development of COPD features, such as an incomplete reversibility of airway obstruction (IRAO), in smoking or non-smoking asthmatic patients, a condition often named Asthma-COPD Overlap (ACO), has been recognized for decades. However, there is a need to know more about the sub-phenotypes of this condition according to smoking. This study aimed at comparing the clinical, physiological and inflammatory features of smoking and non-smoking asthmatic patients exhibiting IRAO. In this cross-sectional study, patients with an IRAO with (ACO, ≥20 pack-years) or without (NS-IRAO, <5 pack-years) significant smoking history completed questionnaires about asthma control (ACQ, score 0-6, 6 = better score) and quality of life (AQLQ, score 1-7, 1 = better score) and performed expiratory flows, lung volume and carbon monoxide diffusion capacity measurements...
April 23, 2018: COPD
https://www.readbyqxmd.com/read/29683730/biologic-drugs-a-new-target-therapy-in-copd
#11
Ahmed Yousuf, Christopher E Brightling
Chronic obstructive pulmonary disease (COPD) is a heterogeneous disease associated with significant morbidity and mortality. Current diagnostic criteria based on the presence of fixed airflow obstruction and symptoms do not integrate the complex pathological changes occurring within the lung and they do not define different airway inflammatory patterns. The current management of COPD is based on 'one size fits all' approach and does not take the importance of heterogeneity in COPD population into account. The available treatments aim to alleviate symptoms and reduce exacerbation frequency but do not alter the course of the disease...
April 23, 2018: COPD
https://www.readbyqxmd.com/read/29658810/early-changes-in-ediary-copd-symptoms-predict-clinically-relevant-treatment-response-at-12-weeks-analysis-from-the-crystal-study
#12
Konstantinos Kostikas, Maryam Aalamian-Mattheis, Veronica Anna Pagano, Xavier Nunez, Robert Fogel, Francesco Patalano, Andreas Clemens
Early detection of treatment response is important in the long-term treatment and management of patients with chronic obstructive pulmonary disease (COPD). This analysis evaluated whether early improvement in symptoms, recorded in the first 7 or 14 days via an electronic diary (eDiary) compared with baseline, can predict clinically meaningful treatment responders at 12 weeks. CRYSTAL was a 12-week, randomized, open-label study that demonstrated the increased effectiveness of indacaterol/glycopyrronium (IND/GLY) or glycopyrronium (GLY), after a direct switch from on-going baseline therapies, in patients with symptomatic COPD and moderate airflow obstruction...
April 16, 2018: COPD
https://www.readbyqxmd.com/read/29658804/comparison-of-effects-of-endurance-and-strength-training-programs-in-patients-with-copd
#13
Michael J Berry, Katherine L Sheilds, Norman E Adair
Comparisons between endurance and strength training in chronic obstructive pulmonary disease (COPD) patients have produced equivocal findings when examining physical function and health-related quality of life (HRQL). One reason for these differences may be due to individual patient responses to the different training modalities. PURPOSE: To compare changes in physical function and HRQL in a group of COPD patients completing both an endurance and a strength training program. METHODS: Eleven mildly diseased patients completed a three month endurance training program and, approximately 5 years later, completed a three month strength training program...
April 16, 2018: COPD
https://www.readbyqxmd.com/read/29608095/stable-copd-treatment-where-are-we
#14
Nicolas Roche
The number of pharmacological treatments available for COPD has increased markedly in the last years, mostly corresponding to new agents, combinations and devices within know pharmacological classes. Hierarchizing these options is not straightforward since expected effects are limited by the intrinsically fixed character of the underlying lung damage. In addition, all options have not been directly compared face-to-face. Therefore, guidelines derive from some level of subjective interpretation of the available evidence...
April 2, 2018: COPD
https://www.readbyqxmd.com/read/29583021/copd-2017-a-year-in-review
#15
Ernesto Crisafulli, Antoni Torres
In this review, we focused on original manuscripts published in the 2017 that provided additional information on the clinical and therapeutic features of the chronic obstructive pulmonary disease (COPD). We have chosen eight of these studies, collected in four topics concerning the pharmacological treatment (tiotropium) of mild-moderate patients, the pharmacological (fluticasone furoate/vilanterol/umeclidinium) and non-pharmacological treatment (non-invasive mechanical ventilation) of severe patients, the etiology of acute exacerbation of COPD involving seasonal airway pathogens and the role of eosinophils with particular interest to the monoclonal antibody directed against interleukin-5 (mepolizumab)...
March 27, 2018: COPD
https://www.readbyqxmd.com/read/29558236/demographic-and-clinical-characteristics-of-copd-patients-at-different-blood-eosinophil-levels-in-the-uk-clinical-practice-research-datalink
#16
Sarah Landis, Robert Suruki, Joe Maskell, Kerina Bonar, Emma Hilton, Chris Compton
Blood eosinophil count may be a useful biomarker for predicting response to inhaled corticosteroids and exacerbation risk in chronic obstructive pulmonary disease (COPD) patients. The optimal cut point for categorizing blood eosinophil counts in these contexts remains unclear. We aimed to determine the distribution of blood eosinophil count in COPD patients and matched non-COPD controls, and to describe demographic and clinical characteristics at different cut points. We identified COPD patients within the UK Clinical Practice Research Database aged ≥40 years with a FEV1 /FVC <0...
March 20, 2018: COPD
https://www.readbyqxmd.com/read/29558226/management-of-copd-in-end-of-life-care-by-spanish-pulmonologists
#17
Patricia Sobradillo Ecenarro, Marta Inchausti Iguiñiz, Sandra Pedrero Tejada, Nuria Marina Malanda, María Alfonso Imizcoz, Laura Ansola Marlasca, Bernardino Alcázar Navarrete
Chronic obstructive pulmonary disease is progressive and in its advanced stage is associated with major disability. Previous studies suggest that patients with this disease receive little palliative care, even in very advanced stages. Given this, our objectives were to describe the clinical practice of Spanish pulmonologists in the care of patients with end-stage chronic obstructive pulmonary disease, to identify potential barriers to implementing palliative care in these patients and to correlate these responses with doctor's years of experience...
March 20, 2018: COPD
https://www.readbyqxmd.com/read/29558200/magnetic-stimulation-therapy-in-patients-with-copd-a-systematic-review
#18
Massimiliano Polastri, Vittoria Comellini, Angela Maria Grazia Pacilli, Stefano Nava
Magnetotherapy (MT) is a therapeutic treatment based on the use of magnetic fields (MF) that can have an anti-inflammatory and analgesic effect. MT represents a possible treatment or an ancillary therapeutic intervention for a wide range of diseases and it is often used in the field of physiotherapeutic practices. A crucial point in the treatment of chronic obstructive pulmonary disease (COPD) patients, to counteract muscular depletion and respiratory symptoms, is represented by physiotherapy. Nevertheless, the knowledge about the application of MF as a therapeutic option in COPD patients is very limited...
March 20, 2018: COPD
https://www.readbyqxmd.com/read/29558165/current-approaches-for-phenotyping-as-a-target-for-precision-medicine-in-copd-management
#19
Jose Luis Lopez-Campos, Stefano Centanni
The study of airway diseases continues to present several challenges for modern medicine. The different disease presentations with variables and overlapping features may result in a real challenge for the clinician. In this context, the concept of precision medicine has started to emerge in order to give answers to some of these challenges from a diagnostic and therapeutic point of view. The main reasons to target for precision medicine in chronic obstructive pulmonary disease (COPD) include that there is variability in the clinical presentation, there is no correlation between the different clinical variables at the patient level, there are a number of relevant clinical variables associated with outcomes, we do have specific therapies for specific patient types, and that there is variability in the clinical response to different therapies...
March 20, 2018: COPD
https://www.readbyqxmd.com/read/29521545/angiotensin-converting-enzyme-inhibitors-and-angiotensin-receptor-blockers-a-promising-medication-for-chronic-obstructive-pulmonary-disease
#20
Ioannis E Vasileiadis, Christos A Goudis, Pinelopi T Giannakopoulou, Tong Liu
Chronic obstructive pulmonary disease (COPD) is a complex disorder that primarily affects the lungs and is characterized not only by local pulmonary, but also by systemic inflammation which promotes the development of extrapulmonary and cardiovascular co-morbidities. Angiotensin converting enzyme (ACE) inhibitors and ARBs (angiotensin receptor blockers) are widely used drugs in the treatment of cardiovascular diseases, with growing evidence suggesting potential benefits in COPD patients. The purpose of this review is to describe the correlation of renin-angiotensin system (RAS) with COPD pathophysiology and to present the latest data regarding the potential role of RAS blockers in COPD...
March 9, 2018: COPD
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