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https://www.readbyqxmd.com/read/29023143/changes-of-emphysema-parameters-over-the-respiratory-cycle-during-free-breathing-preliminary-results-using-respiratory-gated-4d-ct
#1
Julia Ley-Zaporozhan, Sebastian Ley, Jürgen Mews, Oliver Weinheimer, Sonja Kandel, Patrik Rogalla
The purpose of this research was to evaluate respiratory gated CT of the lung in patients with COPD for analysis of parenchymal characteristics who were potential candidates for volume reduction surgery. Eleven patients with clinically known emphysematous disease underwent a respiratory gated, free-breathing 64-multislice-CT (Aquilion 64, Toshiba). Retrospective image reconstruction was performed similar to cardiac CT at every 10% of the respiratory loop, resulting in 10 complete volumetric datasets at 10 equidistant time points...
October 12, 2017: COPD
https://www.readbyqxmd.com/read/29020525/social-determinants-of-adherence-to-pulmonary-rehabilitation-for-chronic-obstructive-pulmonary-disease
#2
Gabriela R Oates, Bryant W Hamby, Irena Stepanikova, Sara J Knight, Surya P Bhatt, Jason Hitchcock, Christopher Schumann, Mark T Dransfield
Adherence to pulmonary rehabilitation (PR) is low. Previous studies have focused on clinical predictors of PR completion. We aimed to identify social determinants of adherence to PR. A cross-sectional analysis of a database of COPD patients (N = 455) in an outpatient PR program was performed. Adherence, a ratio of attended-to-prescribed sessions, was coded as low (<35%), moderate (35-85%), and high (>85%). Individual-level measures included age, sex, race, BMI, smoking status, pack-years, baseline 6-minute walk distance (6MWD: <150, 150-249, ≥250), co-morbidities, depression, and prescribed PR sessions (≤20, 21-30, >30)...
October 11, 2017: COPD
https://www.readbyqxmd.com/read/28985109/bioequivalence-of-a-liquid-formulation-of-alpha1-proteinase-inhibitor-compared-with-prolastin%C3%A2-c-lyophilized-alpha1-pi-in-alpha1-antitrypsin-deficiency
#3
Alan F Barker, Michael A Campos, Mark L Brantly, James M Stocks, Robert A Sandhaus, Douglas Lee, Kimberly Steinmann, Jiang Lin, Susan Sorrells
This study evaluated the bioequivalence, safety, and immunogenicity of a new liquid formulation of human plasma-derived alpha1-proteinase inhibitor, Liquid Alpha1-PI, compared with the Lyophilized Alpha1-PI formulation (Prolastin®-C), for augmentation therapy in patients with alpha1-antitrypsin deficiency (AATD). In this double-blind, randomized, 20-week crossover study, 32 subjects with AATD were randomized to receive 8 weekly infusions of 60 mg/kg of Liquid Alpha1-PI or Lyophilized Alpha1-PI. Serial blood samples were drawn for 7 days after the last dose followed by 8 weeks of the alternative treatment...
October 6, 2017: COPD
https://www.readbyqxmd.com/read/28949781/rem-sleep-imposes-a-vascular-load-in-copd-patients-independent-of-sleep-apnea
#4
Grote L, Sommermeyer D, Ficker Jh, Randerath W, Penzel T, Fietze I, Sanner B, Hedner J, Schneider H
Arterial stiffness, a marker for cardiovascular risk, is increased in patients with Chronic Obstructive Pulmonary Disease (COPD) and Obstructive Sleep Apnea (OSA). The specific influence of both on arterial stiffness during sleep is unknown. Nocturnal arterial stiffness (Pulse Propagation Time (PPT) of the finger pulse wave) was calculated in 142 individuals evaluated for sleep apnea: 27 COPD patients (64.7 ± 11y, 31.2 ± 8 kg/m(2)), 72 patients with cardiovascular disease (CVD group, 58.7 ± 13y, 33.6 ± 6 kg/m(2)) and 43 healthy controls (HC group 49...
September 26, 2017: COPD
https://www.readbyqxmd.com/read/28949773/gene-gene-interactions-between-glutathione-s-transferase-m1-and-matrix-metalloproteinases-1-9-and-12-in-chronic-obstructive-pulmonary-disease-in-serbians
#5
Marija Stankovic, Aleksandra Nikolic, Ljudmila Nagorni-Obradovic, Natasa Petrovic-Stanojevic, Dragica Radojkovic
Chronic obstructive pulmonary disease (COPD) is a complex disorder influenced by multiple genetic and environmental factors, as well as their interactions. Since elevated oxidative stress and protease activity characterize the pathogenesis of COPD, variants of genes that can affect these processes have been commonly studied in COPD. However, interactions among genes that can influence oxidative stress and protease activity remain poorly investigated in COPD. The aim of this study was to look into the role of functional variants in matrix metalloproteinases (MMPs) 1, 9, and 12 in the occurrence and/or modulation of COPD, and to analyze their interactions with glutathione S-transferases (GSTs) M1, T1, and P1 in the pathogenesis of COPD in Serbians...
September 26, 2017: COPD
https://www.readbyqxmd.com/read/28891722/requirements-strengths-and-weaknesses-of-inhaler-devices-for-copd-patients-from-the-expert-prescribers-point-of-view-results-of-the-epoca-delphi-consensus
#6
Francisco García-Río, Juan J Soler-Cataluña, Bernardino Alcazar, José L Viejo, Marc Miravitlles
The study aimed to assess the preferences of expert physicians about the requirements for inhalation devices for patients with chronic obstructive pulmonary disease (COPD) and to identify the most relevant advantages and disadvantages to their prescription. In a two-round Delphi survey, 96 Spanish COPD-expert pulmonologists completed an internet-based questionnaire to evaluate the degree of importance of the characteristics of the inhaler devices in their choice for COPD. The requirements needed for use in COPD were that the device permits a high pulmonary deposit of the drug, allowed its dispensation at low inspiratory flows, did not require hand-mouth coordination, generated an exact and reproducible dose, its operation was easy to teach, provided the perception of a correct inhalation, had an intuitive use mechanism and security mechanisms to prevent overdosing and generates a reduced oropharyngeal deposit (very good consensus)...
September 11, 2017: COPD
https://www.readbyqxmd.com/read/28836871/effectiveness-of-smartphone-devices-in-promoting-physical-activity-and-exercise-in-patients-with-chronic-obstructive-pulmonary-disease-a-systematic-review
#7
María Del M Martínez-García, Juan D Ruiz-Cárdenas, Roberto A Rabinovich
The objectives of this systematic review were to analyse existing evidence on the efficacy of smartphone devices in promoting physical activity (PA) in patients with chronic obstructive pulmonary disease (COPD) and to identify the validity and precision of their measurements. A systematic review was undertaken across nine electronic databases: WOS Core Collection, PubMed, CINAHL, AMED, Academic Search Complete, Cochrane Central Register of Controlled Trials, SciELO, LILACS and ScienceDirect. Randomized and non-randomized controlled clinical trials were identified...
August 24, 2017: COPD
https://www.readbyqxmd.com/read/28813176/validating-the-concept-of-copd-control-a-real-world-cohort-study-from-the-united-kingdom
#8
Anjan Nibber, Alison Chisholm, Juan José Soler-Cataluña, Bernardino Alcazar, David Price, Marc Miravitlles
The concept of Chronic Obstructive Pulmonary Disease (COPD) control has been developed to inform therapeutic decision-making. We explored the validity of a definition of COPD control in a representative population of patients with COPD in the United Kingdom. Electronic medical records and linked COPD questionnaire data from the Optimum Patient Care Research Database were used to characterize control status. Patients were aged ≥40 years, with spirometry-confirmed COPD, current or ex-smokers, and continuous records throughout the study period...
August 16, 2017: COPD
https://www.readbyqxmd.com/read/28799856/severity-of-airflow-obstruction-in-chronic-obstructive-pulmonary-disease-copd-proposal-for-a-new-classification
#9
Sonia Coton, William M Vollmer, Eric Bateman, Guy B Marks, Wan Tan, Filip Mejza, Sanjay Juvekar, Christer Janson, Kevin Mortimer, Mahesh P A, A Sonia Buist, Peter G J Burney
Current classifications of Chronic Obstructive Pulmonary Disease (COPD) severity are complex and do not grade levels of obstruction. Obstruction is a simpler construct and independent of ethnicity. We constructed an index of obstruction severity based on the FEV1/FVC ratio, with cut-points dividing the Burden of Obstructive Lung Disease (BOLD) study population into four similarly sized strata to those created by the GOLD criteria that uses FEV1. We measured the agreement between classifications and the validity of the FEV1-based classification in identifying the level of obstruction as defined by the new groupings...
August 11, 2017: COPD
https://www.readbyqxmd.com/read/28753067/a-randomized-placebo-controlled-phase-2-trial-of-cnto-6785-in-chronic-obstructive-pulmonary-disease
#10
Andreas Eich, Veronika Urban, Marek Jutel, Jiri Vlcek, Jae Jeong Shim, Vasiliy I Trofimov, Chong-Kin Liam, Ping-Hung Kuo, Yanyan Hou, Jun Xiao, Patrick Branigan, Christopher D O'Brien
Interleukin (IL)-17A may be an underlying factor in the pathophysiology of chronic obstructive pulmonary disease (COPD). Anti-IL-17 monoclonal antibodies have been used successfully in treating several immune-mediated inflammatory diseases. This phase 2, randomized, placebo-controlled, double-blind, parallel-group, proof-of-concept study is the first clinical study evaluating the efficacy and safety of the anti-IL-17A monoclonal antibody CNTO 6785 in patients with symptomatic moderate-to-severe COPD. Patients were treated with CNTO 6785 (n = 93) or placebo (n = 94) intravenously at Weeks 0, 2, and 4 (induction), then Weeks 8 and 12, and followed till Week 24...
July 28, 2017: COPD
https://www.readbyqxmd.com/read/28745532/regulatory-t-cell-distribution-within-lung-compartments-in-copd
#11
Davi S Sales, Juliana T Ito, Ivy A Zanchetta, Raquel Annoni, Marcelo V Aun, Luiz Fernando S Ferraz, Daniela A B Cervilha, Elnara Negri, Thais Mauad, Mílton A Martins, Fernanda D T Q S Lopes
The importance of the adaptive immune response, specifically the role of regulatory T (Treg) cells in controlling the obstruction progression in smokers, has been highlighted. To quantify the adaptive immune cells in different lung compartments, we used lung tissues from 21 never-smokers without lung disease, 22 current and/or ex-smokers without lung disease (NOS) and 13 current and/or ex-smokers with chronic obstructive pulmonary disease (COPD) for histological analysis. We observed increased T, B, IL-17 and BAFF(+) cells in small and large airways of COPD individuals; however, in the NOS, we only observed increase in T and IL-17(+) cells only in small airways...
July 26, 2017: COPD
https://www.readbyqxmd.com/read/28745528/predicting-one-year-mortality-after-a-first-hospitalization-for-chronic-obstructive-pulmonary-disease-an-eight-variable-assessment-score-tool
#12
Alain Vanasse, Josiane Courteau, Simon Couillard, Marie-France Beauchesne, Pierre Larivée
Several authors have studied predictors of outcomes following a hospitalization for chronic obstructive pulmonary disease (COPD); however, few have reported outcomes following a first hospitalization for COPD. The objective is to develop a predictive mortality risk model in patients surviving a first hospitalization for COPD. This is a retrospective cohort study using linked administrative and clinical data. The cohort included 1129 patients of 40-84 years, discharged alive from a hospitalization for COPD in a regional hospital (Sherbrooke, Canada) between 04/2006 and 03/2013 and to whom were prescribed at least two COPD drugs during their hospitalization...
July 26, 2017: COPD
https://www.readbyqxmd.com/read/28745522/pharmacological-characterization-of-the-interaction-between-tiotropium-and-olodaterol-administered-at-5-5-concentration-ratio-in-equine-bronchi
#13
Luigino Calzetta, Paola Rogliani, Maurizio Mattei, Pietro Alfonsi, Giuseppe Cito, Elena Pistocchini, Mario Cazzola, Maria Gabriella Matera
Equine airways represent a suitable ex vivo model to study the functional impact of pharmacological treatments on human chronic obstructive pulmonary disorders, such as asthma and chronic obstructive pulmonary disease (COPD). We aimed to characterize the pharmacological interaction between the long-acting muscarinic antagonist (LAMA) tiotropium and the long-acting β2-agonist (LABA) olodaterol in equine airways. The effect of tiotropium and olodaterol, administered alone and in combination at the ratio of concentrations reproducing ex vivo the concentration-ratio delivered by the currently available fixed-dose combination (FDC) (5:5), was investigated on the cholinergic contractile tone induced by the parasympathetic activation of equine isolated airways...
July 26, 2017: COPD
https://www.readbyqxmd.com/read/28876204/external-validation-of-the-comorbidity-test
#14
Nicholas Villalobos, Ross Davidson, Uzair K Ghori, Yara Abdou, Jawad Abukhalaf, Rodrigo Vazquez Guillamet
The COmorbidity TEst (COTE) is a Chronic Obstructive Pulmonary Disease (COPD)-specific co-morbidity score created to predict mortality. Before its wide application at the University of New Mexico we intended to validate it. The study was conducted at the University of New Mexico Hospital (UNMH) in Albuquerque, NM, USA, a tertiary academic hospital. Consecutive patients with the clinical diagnosis of COPD were identified using the hospital's medical records system and included if they were older than 40 years, had smoked at least 20 pack-years and their post bronchodilator forced expiratory volume in the first second/forced vital capacity (FEV1/FVC) was <0...
October 2017: COPD
https://www.readbyqxmd.com/read/28876203/classifying-the-severity-of-copd-are-we-there-yet-editorial-for-coton-s-et-al-severity-of-airflow-obstruction-in-chronic-obstructive-pulmonary-disease-copd-proposal-for-a-new-classification
#15
https://www.readbyqxmd.com/read/28753070/impact-of-mucolytic-agents-on-copd-exacerbations-a-pair-wise-and-network-meta-analysis
#16
Mario Cazzola, Paola Rogliani, Luigino Calzetta, Nicola A Hanania, Maria Gabriella Matera
Mucolytics are potentially useful for the management of chronic obstructive pulmonary disease (COPD), although there is conflicting advice on their use in different guideline documents. Furthermore, there is paucity of data comparing the efficacy of the different mucolytic agents in reducing the odds of COPD exacerbations. We performed pair-wise and network meta-analyses to evaluate the impact of mucoly-tics in COPD. Randomized clinical trials lasting at least 3 months and investigating the effects of mucolytics on COPD exacerbations were identified from published studies and repository databases...
October 2017: COPD
https://www.readbyqxmd.com/read/28745525/balance-and-falls-in-acute-exacerbation-of-chronic-obstructive-pulmonary-disease-a-prospective-study
#17
Cristino C Oliveira, Annemarie L Lee, Jennifer McGinley, Gary P Anderson, Ross A Clark, Michelle Thompson, Sandy Clarke, Tamara Baker, Louis B Irving, Linda Denehy
Individuals with chronic obstructive pulmonary disease (COPD) have demonstrated balance impairment and a higher fall incidence. However, these have not been investigated in acute exacerbations of the disease (ECOPD). This study evaluates balance in patients during an ECOPD compared to stable COPD and healthy controls, and examines the fall incidence rate after hospitalisation due to ECOPD compared to individuals with stable COPD. Balance performance of 26 hospitalised patients with ECOPD was compared to 26 community-dwelling participants with stable COPD and 25 matched healthy controls...
October 2017: COPD
https://www.readbyqxmd.com/read/28745524/should-patients-switched-from-d-to-b-in-the-gold-2017-classification-be-discontinued-from-inhaled-corticosteroids
#18
Matevz Harlander, Miriam Barrecheguren, Matjaz Turel, Marc Miravitlles
Inhaled corticosteroids (ICSs) are the cornerstone of the treatment of asthma, but their role in COPD is limited. Several guidelines recommend their use in patients with severe airflow limitation, frequent exacerbations and asthma-COPD overlap (ACO), while the previous GOLD document recommended ICS for patients with high risk of exacerbations and a high level of symptoms (group D). Following the changes in the GOLD document 2017 update, in which impaired lung function is no longer considered as a determinant of exacerbation risk, a high number of COPD patients can now be labeled as group B (low risk of exacerbations and high level of symptoms) instead of D, and hence, no longer fulfill the indication for ICS...
October 2017: COPD
https://www.readbyqxmd.com/read/28636452/epidemiology-of-niv-for-acute-respiratory-failure-in-copd-patients-results-from-the-international-surveys-vs-the-real-world
#19
Aylin Ozsancak Ugurlu, Mehmet Ali Habesoglu
Non-invasive ventilation (NIV) has been recommended as the  first-line ventilation modality for acute respiratory failure (ARF) due to acute exacerbation of chronic obstructive pulmonary disease (AECOPD) based on strong evidence. However, everyday clinical practice may differ from findings of multiple randomized controlled trials. Physicians and respiratory therapists involved in NIV management have been queried about its utilization and effectiveness. In addition to these estimates, cohort studies and analysis of large inpatient dataset of patients with AECOPD and ARF managed with NIV have been extensively published over the last two decades...
August 2017: COPD
https://www.readbyqxmd.com/read/28594596/mortality-in-patients-admitted-for-concurrent-copd-exacerbation-and-pneumonia
#20
Amir Sharafkhaneh, Shahriar Tavakoli-Tabasi, Daniel Musher
No abstract text is available yet for this article.
August 2017: COPD
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