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L K Teja Boppana, Sateesh Sakhamuri, Terence Seemungal
Globally, mortality, morbidity and the economic burden of chronic obstructive pulmonary disease (COPD) are on the rise. In addition, its diagnosis continues to pose challenges to the physicians, which is compounded further by its new feature "spirometric instability." Based on the findings from the two recent observational studies, the Global Initiative for Chronic Obstructive Lung Disease (GOLD) recommended repeat spirometry for the individuals with a fixed ratio between 0.6 and 0.8. In this perspective, we discuss the uncertainties and consequences of this critical update in the 2018 GOLD report...
December 30, 2018: COPD
William Stringer, Darcy Marciniuk
Chronic obstructive pulmonary disease (COPD) is a common multisystem inflammatory disease with ramifications involving essentially all organ systems. Pulmonary rehabilitation is a comprehensive program designed to prevent and mitigate these disparate systemic effects and improve patient quality of life, functional status, and social functioning. Although initial patient assessment is a prominent component of any pulmonary rehabilitation (PR) program, cardiopulmonary exercise testing (CPET) is not regularly performed as a screening physiologic test prior to PR in COPD patients...
December 30, 2018: COPD
S Zewari, L Hadi, F van den Elshout, R Dekhuijzen, Y Heijdra, P Vos
COPD and obesity often coexist and there is a complex interaction between them. Our aim was to evaluate the prevalence of obesity in a secondary care COPD population. Furthermore, the presence of comorbidities in obese (COPDOB ) and non-obese COPD (COPDNO ) individuals was studied. In 1654 COPD patients (aged ≥18 years) who visited a pulmonologist between January 2015 and December 2015, patient characteristics, pulmonary function tests and comorbidities were obtained from the medical records. Subjects were categorized according their BMI as underweight (<18...
December 4, 2018: COPD
Ana Oliveira, Ana Machado, Alda Marques
Interpreting clinical changes during acute exacerbations of chronic obstructive pulmonary disease (AECOPD) is challenging due to the absence of established minimal detectable (MDD) and important (MID) differences for most respiratory measures. This study established MDD and MID for respiratory measures in outpatients with AECOPD following pharmacological treatment. COPD assessment test (CAT), modified Borg scale (MBS), modified British Medical Research Council (mMRC) questionnaire, peripheral oxygen saturation (SpO2 ), computerised respiratory sounds and forced expiratory volume in one second (FEV1 ) were collected within 24-48 hour of an AECOPD and after 45 days of pharmacological treatment...
December 4, 2018: COPD
Berne Eriksson, Helena Backman, Linda Ekerljung, Malin Axelsson, Anne Lindberg, Eva Rönmark, Bo Lundbäck
Cardiovascular diseases are the most common comorbidities in COPD, due to common risk factors such as smoking. The prevalence of current smokers in Sweden has decreased over four decades to around 10%. The aim of the present study was to investigate the prevalence, distribution and associations of cardiovascular comorbidities in COPD by disease severity in two large areas of Sweden, both with low-smoking prevalence. Data from clinical examinations in 2009-2012, including spirometry and structured interview, from two large-scale population studies, the West Sweden Asthma Study (WSAS) and the OLIN Studies in Northern Sweden, were pooled...
November 26, 2018: COPD
Balazs Antus, Csilla Paska, Beatrix Simon, Imre Barta
Superoxide dismutases (SODs) and catalase (CAT) have been implicated as major antioxidant enzymes of the human lungs. In this study, we investigated whether activities of these enzymes are altered in the airways of patients hospitalized with acute exacerbation of chronic obstructive pulmonary disease (AECOPD). SOD and CAT activities were measured in the sputum, exhaled breath condensate, and serum of 36 COPD patients experiencing a severe exacerbation. Measurements were performed using colorimetric assays in samples collected at the time of hospital admission and at the time of hospital discharge following treatment of AECOPD...
November 26, 2018: COPD
Fernanda C Lanza, Rejane A S Castro, Anderson A de Camargo, Drielly J M Zanatta, Samia Rached, Rodrigo Athanazio, Alberto Cukier, Rafael Stelmach, Simone Dal Corso
The COPD assessment test (CAT) is a short questionnaire developed to help patients and clinicians to assess the impact of symptoms in routine clinical practice. We aimed to validate and to test the reproducibility of CAT in patients with bronchiectasis and correlate with the severity of dyspnea, aerobic and functional capacity, and physical activity in daily life. This is a cross-sectional study, patients with bronchiectasis underwent spirometry, cardiopulmonary exercise test (CPET), incremental shuttle walk test (ISWT), Saint George`s Respiratory Questionnaire (SGRQ), and received pedometer...
November 23, 2018: COPD
Irene Coppolino, Paolo Ruggeri, Francesco Nucera, Mario Francesco Cannavò, Ian Adcock, Giuseppe Girbino, Gaetano Caramori
There are only few human translational studies performed in the area of stem cell research in patients with chronic obstructive pulmonary disease (COPD) and/or pulmonary emphysema. Before progress to clinical trials with stem cells we strongly believe that more human translational studies are essential, otherwise, the clinical rationale would be solely based on limited in vitro and animal studies. In the future, stem cell therapy could be a treatment for this incurable disease. As of now, stem cell therapy is still to be considered as an area of active research, lacking any strong rationale for performing clinical trials in COPD...
November 23, 2018: COPD
Thomas Reijnders, Michael Schuler, Danijel Jelusic, Thierry Troosters, Wim Janssens, Konrad Schultz, Andreas von Leupoldt
Psychological factors such as negative affect have been demonstrated to impact course and treatment of chronic obstructive pulmonary disease (COPD). However, little is known about the respective impact of social factors. In several other chronic diseases, loneliness has been shown to predict morbidity, but little is known about its impact on COPD. Therefore, this study examined the associations between loneliness and outcome measures of a pulmonary rehabilitation program (PR). Before and after a 3-week inpatient PR program, patients with COPD (N = 104) underwent a 6-min walking test to measure functional exercise capacity...
November 7, 2018: COPD
Juan Marco Figueira Gonçalves, María Dolores Martín Martínez, Lina Inmaculada Pérez Méndez, Miguel Ángel García Bello, Ignacio Garcia-Talavera, Sara García Hernández, David Díaz Pérez, Natalia Bethencourt Martín
The COMCOLD score was developed to quantify the impact of comorbidities on health status in patients with chronic obstructive pulmonary disease (COPD). The objective of this study is to evaluate the association between health status in outpatients with COPD according to COMCOLD score and the GOLD 2017 groups according to symptoms (B and D vs. A and C) and exacerbations (C and D vs. A and B). 439 patients were included. The average score was 2.4 ± 3. 48% of cases had a COMCOLD score >0. The most symptomatic patients (B and D vs...
November 6, 2018: COPD
Adriana Olivares, Michele Vitacca, Laura Comini
Combining objective tools with clinical decision (CD) may help clinicians identify the priority for pulmonary rehabilitation (PR) in patients with COPD. We aimed to assess the specificity, sensitivity and efficiency of a new tool, the Pulmonary Rehabilitation Decisional Score (PRDS), and its correlation with the BODE index (BI) and CD in assigning PR priority. We retrospectively compared the three methods (CD vs. PRDS vs. BI) in 124 patients. We assigned low priority (LP), high priority (HP) and very high priority (VHP) to PR based on a priori scores of PRDS (LP = 0-10; HP = 11-17; VHP ≥18) and BI (LP = 0-2; HP = 3-5; VHP ≥6) and compared these with CD...
November 6, 2018: COPD
Janos Porszasz, Vito Brusasco
No abstract text is available yet for this article.
November 2, 2018: COPD
Ignacio Blanco, Isidro Diego, Patricia Bueno, Eloy Fernández, Francisco Casas-Maldonado, Cristina Esquinas, Joan B Soriano, Marc Miravitlles
Surveys estimating chronic obstructive pulmonary disease (COPD) prevalence are unevenly distributed in the Americas, which make it difficult to estimate accurately its geographical distribution. The geographic information system inverse distance weighted (IDW) interpolation technique has proved to be an effective tool in spatial distribution estimation of epidemiological variables, even when real data are few or widely spread. We aimed to represent cartographically the COPD prevalence in the Americas by means of a blue to red scale representation of the prevalence data, where different values are represented as different colours, and a population density filtered IDW interpolation mapping, where areas with a population density <0...
October 30, 2018: COPD
Suela Demiri, Christine Lorut, Antoine Rabbat, Daniel Luu van Lang, Aurelie Lefebvre, Jean-François Regnard, Charles-Marc Samama, Daniel Dusser, Nicolas Roche, Marco Alifano
Chronic obstructive pulmonary disease (COPD) is a risk factor of post-operative complications after lung cancer resection. The influence of the "frequent exacerbator (FE)" phenotype (at least three exacerbations per year) is unknown. Postoperative outcomes of frequent exacerbators (POFE) was a prospective observational study of patients with COPD undergoing lung resection for cancer. The inclusion criteria were: age >40 years, FEV1/FVC <70%, non-urgent surgery for lung cancer, filled out self-questionnaires...
October 30, 2018: COPD
Marceli Rocha Leite, Ercy Mara Cipulo Ramos, Ana Paula Coelho Figueira Freire, Bruna Spolador de Alencar Silva, Juliana Nicolino, Luiz Carlos Marques Vanderlei, Dionei Ramos
Despite the many benefits of performing physical exercise in patients with chronic obstructive pulmonary disease (COPD), information on the response of acute cardiac autonomic modulation in subjects with moderate and severe COPD during and after an aerobic exercise session at different intensities is unknown. The aim of this study was to evaluate the response of cardiac autonomic modulation in patients with moderate and severe COPD during and after an aerobic exercise session at different intensities. Twenty-seven patients with COPD, divided into: Moderate Group and Severe Group, underwent an aerobic exercise sessions with intensities equivalent to 60% and 90% of velocity corresponding to peak oxygen consumption...
October 30, 2018: COPD
(no author information available yet)
No abstract text is available yet for this article.
October 2, 2018: COPD
(no author information available yet)
No abstract text is available yet for this article.
October 2, 2018: COPD
Lanny S Inabnit, Christopher Blanchette, Cynthiya Ruban
Chronic Obstructive Pulmonary Disease (COPD) has a significant burden on patients and the healthcare system. There is a link between COPD and comorbidities such as congestive heart failure (CHF), fluid and electrolyte disorders, and renal failure. This adds to the complexity of healthcare in these patients. The objective of this study is to determine if certain comorbidities affect length of stay. A sample of 3,399 patients with COPD were assessed from the Premier© healthcare database. The cohort had a mean (standard deviation (SD)) age of 68...
October 1, 2018: COPD
Jinping Zheng, Nanshan Zhong, Changzheng Wang, Yijiang Huang, Ping Chen, Limin Wang, Fuxin Hui, Li Zhao, Haoyan Wang, Linda Luo, Xin Du, Aik Han Goh, David A Lipson
The FULFIL study evaluated once-daily fluticasone furoate/umeclidinium/vilanterol (FF/UMEC/VI) 100 µg/62.5 µg/25 µg versus twice-daily budesonide/formoterol (BUD/FOR) 400 µg/12 µg in patients with symptomatic COPD at risk of exacerbations. FULFIL demonstrated clinically meaningful and statistically significant improvements at Week 24 in trough forced expiratory volume in 1 second (FEV1 ), St George's Respiratory Questionnaire (SGRQ) Total scores and reduced exacerbation frequency. Predefined analyses were performed to evaluate treatment effects in a subgroup of patients recruited in China (China subgroup; FF/UMEC/VI, n = 32; BUD/FOR, n = 29)...
September 28, 2018: COPD
Annia Schreiber, Francesca Cemmi, Nicolino Ambrosino, Piero Ceriana, Cinzia Lastoria, Annalisa Carlucci
The aim of our study was to evaluate the prevalence and predictors of obstructive sleep apnea (OSA) in patients with chronic obstructive pulmonary disease (COPD) undergoing inpatient pulmonary rehabilitation programs (PRPs). A retrospective data review of consecutive stable patients with a known diagnosis of COPD, admitted for PRP between January 2007 and December 2013. Full overnight polysomnography (PSG) and Epworth Sleepiness Scale (ESS) were assessed in all patients. Out of 422 evaluated patients, 190 (45%) showed an Apnea Hypopnea Index (AHI) ≥ 15 events/hour and underwent OSA treatment...
September 21, 2018: COPD
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