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Current Drug Delivery

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https://www.readbyqxmd.com/read/28215173/cxcr4-targeted-nanoparticles-reduce-cell-viability-induce-apoptosis-and-inhibit-sdf-1%C3%AE-induced-bt-549-luc-cell-migration-in-vitro
#1
Chuda Chittasupho, Prartana Kewsuwan, Takashi Murakami
CXCR4 possesses a critical role in several intracellular events such as chemotaxis, invasion and adhesion, which are associated with metastasis of cancer cell. In this study, CXCR4 targeted polymeric nanoparticle was developed for delivering cytotoxic drug and blocking the chemokine induced migration of cells expressing CXCR4. A peptide which was a linear form of CXCR4 antagonist (LFC131) was attached to PLGA nanoparticles (LFC131-NPs) and PLGA nanoparticles encapsulating DOX (LFC131-DOX-NPs). The cellular binding and internalization of LFC131-DOX-NPs were investigated...
February 16, 2017: Current Drug Delivery
https://www.readbyqxmd.com/read/28201966/synthesis-and-biological-evaluation-of-mutual-prodrugs-of-carboxylic-group-containing-some-non-steroidal-anti-inflammatory-drugs-and-propyphenazone
#2
Sucheta Ohlan, Meenu Paliwal, Ruchita Ruchita, Shilpa Jain, Monika Monika, Himanshu Himanshu
Non-steroidal anti-inflammatory drugs (NSAIDs); ketorolac (KA), niflumic acid (NA), tolfenamic acid (TA) were conjugated with propyphenazone derivative 3-Hydroxymethyl propyphenazone (HMP) by direct coupling and by using spacer technique with the objective of obtaining gastro-sparing NSAIDs prodrugs devoid of ulcerogenic side effects. Mutual prodrugs were synthesized and their structures were confirmed and characterized using IR, 1H NMR, 13C NMR, mass spectroscopy and their purity was established by elemental analysis...
February 13, 2017: Current Drug Delivery
https://www.readbyqxmd.com/read/28201965/preparation-and-characterization-of-silymarin-synchronized-and-sustained-release-dropping-pill
#3
Zhi-Hong Liu, Xue-Jing Li, Ai-Wen Huang, Jing Zhang, Hong-Tao Song
PURPOSE: This study aimed to develop a synchronized and sustained-release silymarin dropping pill, and to evaluate its pharmacokinetic characteristics. METHODS: Polyoxyethylene stearate, glyceryl monostearate, and stearic acid were used to prepare the dropping pills. X-ray powder diffraction, differential scanning calorimetry, and release were used to evaluate its physicochemical properties. The plasma concentration of silybin in beagle dogs after oral administration of silymarin dropping pills and silymarin capsule was determined by RP-HPLC...
February 13, 2017: Current Drug Delivery
https://www.readbyqxmd.com/read/28155595/cholinergic-anti-inflammatory-pathway-and-stroke
#4
Kamil Duris, Jolana Lipkova, Michal Jurajda
Stroke is devastating cerebrovascular event which is responsible for 6.7 million deaths each year worldwide. Inflammation plays an important role in the pathophysiology of stroke. Targeting inflammation after stroke is highly actual topic for both experimental and clinical research. Cholinergic anti-inflammatory pathway (CHAIP) is a physiological mechanism by which central nervous system regulates immune response and controls inflammation. Vagus nerve, spleen and α7 nicotinic acetylcholine receptor (α7 nAChR) are the main components of CHAIP...
February 1, 2017: Current Drug Delivery
https://www.readbyqxmd.com/read/28137241/evaluation-of-gentamicin-and-lidocaine-release-profile-from-gum-acacia-crosslinked-poly-2-hydroxyethylmethacrylate-carbopol-based-hydrogels
#5
Baljit Singh, Abhishek Dhiman
In this manuscript an attempt has been made to incorporate both, antibiotic agent 'gentamicin' and pain relieving agent 'lidocaine' into the gum acacia-poly(2-hydroxyethylmethacrylate)-carbopol based hydrogel for wound dressing application. Drug release, gel strength, network parameter, antimicrobial activity and biodegradation properties of hydrogel have been evaluated. Porous microstructure of the hydrogel was observed in cryo-SEM images. The hydrogel showed mesh size 37.29 nm, cross-link density 2.19× 10-5 mol/cm3, molecular weight between two cross-links 60...
January 27, 2017: Current Drug Delivery
https://www.readbyqxmd.com/read/28128069/oral-biodisposition-study-of-ritodrine-after-its-buccal-administration-in-rats
#6
Hiraku Onishi, Kei Yumoto, Osamu Sakata
BACKGROUND: In the previous study, buccal absorption of ritodrine (RD) hydrochloride was reported in vivo. As a result, buccal dosing of RD solution was found to be useful for the maintenance of effective plasma concentration. However, in order to find out the dosing schedule more clearly, it is important to clarify the in vivo drug behavior. OBJECTIVE: The biodistributions of RD in oral cavity and buccal mucosal were investigated in order to understand the in vivo drug behavior after the buccal application...
January 26, 2017: Current Drug Delivery
https://www.readbyqxmd.com/read/28128068/mistletoe-and-garlic-extracts-as-polyurethane-carriers-a-possible-remedy-for-choroidal-melanoma
#7
Melania F Munteanu, Aurel Ardelean, Florin Borcan, Svetlana I Trifunschi, Ramona Gligor, Simona A Ardelean, Dorina Coricovac, Iulia Pinzaru, Florina Andrica, Livia-Cristina Borcan
Melanoma is known as the most dangerous form of skin cancer; whereas the malignant choroidal melanoma is an orphan disease known as the most common primary intraocular malignancy in adults. Literature suggests that the consumption of garlic and/or mistletoe leads to a reduced risk of developing cancer. The obtained microstructures present sizes between 1.05 and 2.60 μm and Zeta potentials between -7 and +36 mV. A good encapsulation was observed on different evaluations (88-92%). It was determined that approx...
January 26, 2017: Current Drug Delivery
https://www.readbyqxmd.com/read/28124617/in-vitro-and-in-vivo-evaluation-of-dmso-and-azone-as-penetration-enhancers-for-cutaneous-application-of-celecoxib
#8
Thassia D Arc Senna, Hilton Antonio Mata Dos Santos, Daniel Mabundu Kibwila, Alvaro Costa Leitão, Alexandre Dos Santos Pyrrho, Marcelo De Pádula, Elaine Cruz Rosas, Tatiana Almeida Pádua, Marilisa Guimarães Lara, Maria Bernadete Riemma Pierre
BACKGROUND: Celecoxib (CXB) has been explored as an anti-inflammatory or chemopreventive drug for topical treatment of skin diseases and cancer. OBJECTIVE: The main aim of this work was to investigate the potential of dimethylsufoxide (DMSO) and Azone (AZ) as penetration enhancers (P.Es) for topical delivery of CXB. METHOD: The in vitro studies, drug release, skin permeability and potential cytotoxicity/genotoxicity were carried out with formulations containing or not DMSO or AZ (5% and 10%)...
January 25, 2017: Current Drug Delivery
https://www.readbyqxmd.com/read/28124616/comparison-of-hcv-core-and-coree1e2-virus-like-particles-generated-by-stably-transfected-leishmania-tarentolae-for-stimulation-of-th1-immune-responses-in-mice
#9
Azam Bolhassani, Noushin Davoudi, Elnaz Agi
Virus-like particles (VLPs) could be improved into successful immunogens as well as a potent delivery vehicle, but however, the current expression systems for VLPs production have some limitations. Recently, we developed a novel strategy to produce two HCV VLPs containing core or coreE1E2 proteins using stably transfected Leishmania tarentolae promastigotes. Then, BALB/c mice were injected by both viral like particles in different immunization strategies such as homologous DNA-, homologous VLP-, and heterologous DNA/ VLP-based immunizations...
January 25, 2017: Current Drug Delivery
https://www.readbyqxmd.com/read/28124615/formulation-of-saudi-propolis-into-biodegradable-chitosan-chips-for-vital-pulpotomy
#10
Gihan F Balata, Mohamed I S Abdelhady, Ghada M Mahmoud, Moustafa A Matar, Amani N Abd El-Latif
BACKGROUND: Propolis has been widely used to treat oral cavity disorders, such as endodontal and periodontal diseases and microbial infections. OBJECTIVE: The study aimed at formulation of commercial Saudi propolis into biodegradable chitosan chips and evaluation of its effectiveness as a pulpotomy agent. METHOD: The composition of 80% ethanolic propolis extract was evaluated regarding its total phenolic content, total flavonoid content and antioxidant activity...
January 25, 2017: Current Drug Delivery
https://www.readbyqxmd.com/read/28034362/araucaria-gum-novel-natural-polymer-for-controlled-drug-delivery-development-in-vitro-and-in-vivo-evaluation-of-araucaria-gum-based-matrix-tablets-for-controlled-release
#11
Divvela Hema Naga Durga, Venkata Ramana Murthy Kolapalli, Duppala Lohithasu
CONTEXT: Assessment of natural polymers in oral controlled drug delivery. OBJECTIVE: The objective of the present investigation was to the assessment of Araucaria gum (AHG) obtained from bark exudates of the Araucaria heterophylla (family: Araucariaceae) for the design of oral controlled release forms, in particular tablet dosage forms by using matrix systems. Diclofenac sodium was used as model drug and compared with the marketed formulation. METHODS: Matrix tablets were prepared by wet granulation technique and 5% w/v of AHG dispersion water was used as granulating agent for preparation of AHG matrix tablets...
December 30, 2016: Current Drug Delivery
https://www.readbyqxmd.com/read/28034361/formulation-and-optimization-of-candesartan-cilexetil-nano-lipid-carrier-in-vitro-and-in-vivo-evaluation
#12
Anjan Paudel, EmptyYN Y Ameeduzzafar, Syed Sarim Imam, Abdul Hafeez, Mohd Fazil, Shahroz Khan, Farhan Jalees Ahmad, Asgar Ali
PURPOSE: The objective of this study was to formulate and optimize Candesartan Cilexetil (CC) loaded nanostructured lipid carriers (NLCs) for enhanced oral bioavailability. METHOD: Glycerol monostearate (GMS), Oleic acid, Tween 80 and Span 40 were selected as a solid lipid, liquid lipid, surfactant and co- surfactant, respectively. The CC-NLCs were prepared by hot emulsion probe sonication technique and optimized using experimental design approach. The formulated CC-NLCs were evaluated for various physicochemical parameters and further optimized formulation (CC-NLC-Opt) was assessed for in-vivo pharmacokinetic and pharmacodynamic activity...
December 30, 2016: Current Drug Delivery
https://www.readbyqxmd.com/read/28034360/role-of-nanoparticles-in-drug-delivery-and-regenerative-therapy-for-bone-diseases
#13
Sonia Gera, Sunitha Sampathi, Sujatha Dodoala
Osteoporosis (OP) is a disease characterized by progressive bone loss due to aging and menopause in women leading to bone fragility with increased susceptibility towards fractures. The silent disease weakens the bone by altering its microstructure and mass. Therapy is based on either promoting strength (via osteoblast action) or preventing disease (via osteoclast action). Current therapy with different drugs belonging to antiresorptive, anabolic and hormonal classification suffers from poor pharmacokinetic and pharmacodynamic profile...
December 30, 2016: Current Drug Delivery
https://www.readbyqxmd.com/read/28000552/studies-of-kp46-and-kp1019-and-the-hydrolysis-product-of-kp1019-in-lipiodol-emulsions-preparation-and-initial-characterizations-as-potential-theragnostic-agents
#14
Berta Cebrián Losantos, Irena Pashkunova-Martic, Norbert Kandler, Bernhard Keppler
OBJECTIVE: In this pilot study, we made use of Lipiodol as a potential carrier of three promising antitumor metal complexes (tris(8-quinolato)gallium(III) (KP46), tetrachlorobis(indazole)ruthenate(III) (KP1019) and the hydrolysis product of KP1019, mer,trans-[RuCl3(H2O)(Hind)2]. METHOD: The stability of the drugs in Lipiodol and the release profile into the aqueous phase were examined independently by three different analytical techniques (high pressure liquid chromatography, HPLC; atom absorption spectroscopy, AAS; and electron spray ionization mass spectrometry, ESI-MS)...
December 20, 2016: Current Drug Delivery
https://www.readbyqxmd.com/read/27919213/characteristics-and-performance-of-flurbiprofen-8-75-mg-spray-for-sore-throat
#15
David Veale, Adrian Shephard, Verity Adams, Charlotte Lidster
BACKGROUND: Sore throat sprays provide targeted relief by delivering the active ingredient directly to the site of pain. Although there are several throat sprays available, they vary with respect to the spray characteristics, thus affecting delivery of the active ingredient to the throat as well as more functional attributes of the product, which have the potential to impact compliance. OBJECTIVE: The characteristics and performance of flurbiprofen 8.75 mg sore throat spray were compared with 12 other sprays...
December 5, 2016: Current Drug Delivery
https://www.readbyqxmd.com/read/27919212/investigating-drug-repositioning-approach-to-design-novel-prodrugs-for-colon-specific-release-of-fexofenadine-for-ulcerative-colitis
#16
Suneela S Dhaneshwar, Priyanka Singh
BACKGROUND: Recent immunologic data implicates involvement of mucosal immune cells of the intestine like eosinophils and mast cells to be functionally involved in the pathogenesis of UC. Mast cell activation is followed by increased secretion and elevated tissue concentration of histamine. Inhibition of mucosal histamine release in colon may be an effective therapeutic approach to treat UC. Some studies report that intestinal inflammation associated with acute and chronic colitis has been ameliorated by fexofenadine in mice...
December 5, 2016: Current Drug Delivery
https://www.readbyqxmd.com/read/27889994/pd-1-pd-ls-a-new-target-for-regulating-the-immunopathogenesis-in-central-nervous-system-disorders
#17
Jie Wu, Zhengquan Yu, Gang Chen
The central nervous system (CNS) was traditionally thought to tolerate inflammatory responses. However, CNS is not completely immune-privileged in recent researches. These responses including Microglia and macrophage activation and peripheral immune cells infiltration have been founded successively. Thus, the traditional view of the adult brain as an immune-privileged organ has been changed. Increasing evidence indicated that the PD-1(programmed cell death-1)/PD-Ls signal pathway plays an important role in regulating the immunopathogenesis of brain following injury...
November 23, 2016: Current Drug Delivery
https://www.readbyqxmd.com/read/27875950/targeted-delivery-of-cabazitaxel-by-conjugation-to-albumin-peg-folate-nanoparticles-using-a-cysteine-acrylate-linker-and-simple-synthesis-conditions
#18
Mohammad Kazem Khoeeniha, Mehdi Esfandyari-Manesh, Hossein Behrouz, Mohsen Amini, Behrang Shiri Varnamkhasti, Fatemeh Atyabi, Rassoul Dinarvand
Cabazitaxel (CBZ) is a new taxane approved by the FDA for treatment of castration-resistant prostate cancer not responding to docetaxel. However, CBZ is not a suitable substrate for p-glycoprotein 60, an efflux pump which transports anticancer drugs out of malignant cells and is therefore a promising drug for treatment of multidrug resistant tumors. Similar to other taxanes, the presence of Tween 80 in the CBZ formulation shows that it is insoluble in water. Therefore, to increase the solubility and circulation time, a CBZ-albumin conjugate was synthesized...
November 22, 2016: Current Drug Delivery
https://www.readbyqxmd.com/read/27848883/osteopontin-as-a-potential-therapeutic-target-for-ischemic-stroke
#19
Qiquan Zhu, Xu Luo, Yun Liu, Jie Zhang, Hansheng Luo, Qin Huang, Yuan Cheng, Zongyi Xie
Ischemic stroke is the third leading cause of death and the most frequent cause of permanent disability in adults worldwide. Tremendous advances have been made in understanding of the pathophysiology of cerebral ischemia, however, there is still no effective neuroprotectant available in the clinical work. Osteopontin (OPN), a multifunctional protein, has been shown to participate in multiple pathophysiological processes of various system diseases, including ischemic brain injury. Mounting evidence indicates that OPN attenuates cerebral damage in ischemic stroke, and possesses multiple neuroprotective effects via diverse signaling pathways...
November 16, 2016: Current Drug Delivery
https://www.readbyqxmd.com/read/27834147/sestrins-a-new-kid-for-stroke-treatment
#20
John H Zhang, Xudan Shi, Liang Xu, Jay Malagult, Jiping Tang, Min Yan
The sestrin family includes several conserved stress-induced proteins that contribute to the maintenance of homeostasis, DNA stability and cell viability in response to various types of injuries. It is well established that the protective functions of AMP-dependent protein kinase (AMPK) and/or mammalian target of rapamycin (mTOR) are regulated by sestrins. Additionally, it has been revealed that sestrins are able to protect cells from oxidative stress by scavenging reactive oxygen species (ROS). The essential involvement of sestrins in mTORC1 inhibition and ROS scavenging signaling pathway, which modulate metabolism homeostasis and regulate autophagy, indicates that sestrins may serve as a potential agent for cell growth, development, metabolism, and neurodegenerative disorders...
November 11, 2016: Current Drug Delivery
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