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Current Drug Delivery

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https://www.readbyqxmd.com/read/28322165/anti-inflammatory-and-anti-arthritic-activity-of-different-milk-based-formulation-of-curcumin-in-rat-model
#1
Sumeet Gupta
Inflammation is the key mediator for arthritis. Plant based products are most useful for treating various disorders, but at the same time drug absorbtion is utmost important for effective therapy. The aim of the study was to find out the therapeutic concern in pharmacokinetic and pharmacodynamic parameters in an arthritis induced rat model. Carrageenan and complete Freud's adjuvant, both were used for an arthritis induction as an animal model. Five different formulations of curcumin were prepared in single toned milk, double toned milk, full fat milk, full fat milk with ghee and in an aqueous suspension...
March 20, 2017: Current Drug Delivery
https://www.readbyqxmd.com/read/28322164/solubilization-and-enhancement-of-ex-vivo-vaginal-delivery-of-progesterone-using-solid-dispersions-inclusion-complexes-and-micellar-solubilization
#2
Abeer S Hassan, Ghareb M Soliman, Mona M El-Mahdy, Gamal El-Din A El-Gindy
Progesterone (PG), a natural female sex hormone is used clinically in menopausal hormone replacement therapy and to control reproductive functions. Its very limited aqueous solubility of 7 µg/ml results in reduced oral bioavailability and low patient compliance when administered in high doses. The aim of this study was to enhance PG aqueous solubility and vaginal delivery using solid dispersion, inclusion complex and micellar solubilization techniques. PG solid dispersions and inclusion complexes were prepared by solvent evaporation method using different polymers, such as cyclodextrins, polyvinyl pyrrolidone (PVP), poly (ethylene glycol) 6000, Pluronic® F-127 and Pluronic® F-68...
March 20, 2017: Current Drug Delivery
https://www.readbyqxmd.com/read/28322163/geriatric-oriented-high-dose-nutraceutical-odts-formulation-and-physicomechanical-characterization
#3
Ahmed M Agiba, Sameh Abdel-Hamid, Maha Nasr, Ahmed S Geneidi
CONTEXT: Oral disintegrating tablets (ODTs) represent a better option than conventional tablets for geriatric population, owing to their fast onset of action and their better patient compliance. OBJECTIVE: Two principal therapeutic high-dose nutraceuticals; chondroitin sulphate and glucosamine were formulated into an oral disintegration tablet (ODT) intended for sublingual administration, and optimized to improve compliance and achieve rapid onset of action in osteoarthritis treatment...
March 20, 2017: Current Drug Delivery
https://www.readbyqxmd.com/read/28322162/arginine-complexes-with-simvastatin-apparent-solubility-in-vitro-dissolution-and-solid-state-characterization
#4
Mmr Meor Mohd Affandi, Minaketan Tripathy, Aba Majeed
Categorized as a Biopharmaceutics Classification System (BCS) Class II drugs, statin exhibit low aqueous solubility and bioavailability thus presenting an obstacle and great challenge to formulation researchers. This paper describes a de novo approach to enhance the aqueous solubility of one of the most commonly prescribed statins i.e. simvastatin (SMV) by forming a complex (SMV-ARG) with cosolute arginine (ARG). The complex has been characterized for its apparent solubility and in vitro dissolution. The solid state characterization has been carried out using Fourier Transform Infra-Red (FTIR) Spectroscopy, Elemental Analysis, X-Ray Powder Diffraction (XRD), Differential Scanning Calorimetry (DSC) analysis, Thermal Gravimetric Analysis (TGA) and Scanning Electron Microscopy (SEM)...
March 20, 2017: Current Drug Delivery
https://www.readbyqxmd.com/read/28302030/gold-nanoparticles-conjugated-levofloxacin-for-improved-antibacterial-activity-over-levofloxacin-alone
#5
Paramdeep Bagga, H H Siddiqui, Juber Akhtar, Tariq Mahmood, Manaal Zahera, Mohd Sajid Khan
Levofloxacin is a potent antibiotic with severe side effects due to its high doses. Bacterial resistance may be due to frequent use of antibiotics. Biogenic gold nanoparticles conjugated levofloxacin (Au-HSA-LvN-NPs) were developed by Human Serum Albumin (HSA) and sulfite reductase-mediated pathways. Au-HSA-LvN-NPs (size = 27.2 ± 1 nm) were readily generated with high emulsion stability zeta potential (̵13.3 mV). The developed nanoparticles were also characterized by UV-visible spectroscopy, Transmission Electron Microscopy and Dynamic Light Scattering techniques...
March 16, 2017: Current Drug Delivery
https://www.readbyqxmd.com/read/28290242/variation-in-impact-of-use-of-different-propellants-and-excipients-in-pharmaceutical-topical-aerosol-then-and-now
#6
Maunab Patra, Meenakshi Patnaik
Skin is the most suitable and recommendable organ of the human body for topical administration of drugs. Drug delivery system is the methodology used to ensure that the drugs entering in to the body through any route into the body, reach its target for pharmacological action. Patients tend to prefer the painless route of drug administration. So, pharmaceutical aerosols were invented meet patient compliance. Many variations in excipients with respect to compatibility to drugs, stability and economy have been used since start to improve the aerosol system of drug delivery...
March 8, 2017: Current Drug Delivery
https://www.readbyqxmd.com/read/28260506/ph-dependent-behavior-of-novel-gellan-beads-loaded-with-naproxen
#7
Tomasz Osmałek, Anna Froelich, Bartłomiej Milanowski, Magdalena Białas, Kinga Hyla, Mirosław Szybowicz
We have designed, formulated and characterized low-acyl gellan gum (GG) macrobeads to be applied as potential carriers for the delivery of naproxen (NPX) to the distal parts of the gastrointestinal tract. The beads were obtained by ionotropic gelation technique. CaCl2 solution (1%, 9.0×10-2 M) was used as a cross-linking medium. Nine different polymer, drug and surfactant (Tween®80) mixtures were used for beads production. The surface and morphology of the dried beads were analyzed by SEM. Raman spectra of NPX powder and the beads confirmed that NPX did not undergo structural changes during production process...
March 3, 2017: Current Drug Delivery
https://www.readbyqxmd.com/read/28240178/efficient-colonic-delivery-of-dsirna-by-pectin-coated-polyelectrolyte-complex-nanoparticles-preparation-characterization-and-improved-gastric-survivability
#8
Zahid Hussain, Haliza Katas, Set Li Yan, Diyanadalila Jamaludin
BACKGROUND: Despite having excellent anticancer efficacy and ability to knockdown gene expression, the therapeutic feasibility of Dicer-substrate small interference RNA (DsiRNA) is limited due to its poor cellular uptake, chemical instability and rapid degradation in biological environments. OBJECTIVE: The present study was aimed to circumvent the pharmaceutical issues related to DsiRNA delivery to colon for the treatment of colorectal cancer. METHOD: In this study, we have prepared water-soluble chitosan (WSC)-DsiRNA complex nanoparticles (NPs) by a simple complexation method and subsequently coated with pectin to protect DsiRNA from gastric milieu...
February 24, 2017: Current Drug Delivery
https://www.readbyqxmd.com/read/28240177/formulation-of-niosomal-gel-for-enhanced-transdermal-lornoxicam-delivery-in-vitro-and-in-vivo-evaluation
#9
Mohamed Shafik El-Ridy, Soad Aly Yehia, Amira Mohamed Mohsen, Sally A El-Awdan, Asmaa Badawy Darwish
The objective of this study was to investigate the potential of niosomal gels as a transdermal delivery system to improve the permeation and anti-inflammatory activity of Lornoxicam (LX). LX niosomes were prepared by thin film hydration technique and were characterized using Transmission Electron Microscopy (TEM), Differential Scanning Calorimetry (DSC), Particle Size analysis and Zeta potential determination. LX niosomal gel/ LX loaded gel were prepared using Carbopol 934 (2%) and were evaluated for their physical appearance, pH and rheological behaviour...
February 24, 2017: Current Drug Delivery
https://www.readbyqxmd.com/read/28240176/preparation-of-porous-%C3%AE-fe2o3-mwo3-multifunctional-nanoparticles-for-drug-loading-and-controlled-release
#10
Hongxia Peng, Qin Huang, Tengyan Wu, Jin Wen, Hengping He
We constructed a novel mesoporous WO3 shell layered γ-Fe2O3@mWO3 (m was short for mesoporous) core-shell structured drug nano-carrier to investigate loading and controllable release properties of ibuprofen (IBU). This nanocomposite composed of mesoporous WO3 shell with magnetic γ-Fe2O3 core. They possesses high surface area of 100.09 m2/g, provides large accessible pore diameter of 6.0 nm for adsorption of drug molecules, high magnetization saturation value of 43.6 emu/g for drug targeting under foreign magnetic fields, quickly convert electromagnetic energy into thermal energy for controlled release by microwave-triggered which was caused by mWO3 shell...
February 24, 2017: Current Drug Delivery
https://www.readbyqxmd.com/read/28240175/clinical-considerations-of-focal-drug-delivery-in-cancer-treatment
#11
Jamie Harris, Bill Chiu
According to the US Center for Disease Control, cancer deaths are the second most common cause of mortality in both adults and children. Definitive treatment of solid tumors involves surgical resection with or without systemic chemotherapy and radiation. The advent of local drug delivery presents a unique treatment modality that can offer substantial benefits in cancer management. Local drug delivery offers targeted drug delivery to cancer tissues while minimizing side effects of the medications. Three main phases in solid tumor management exist for the treating physician: initial diagnosis with tissue biopsy, surgical resection with or without chemotherapy, and management of metastatic disease...
February 24, 2017: Current Drug Delivery
https://www.readbyqxmd.com/read/28215173/cxcr4-targeted-nanoparticles-reduce-cell-viability-induce-apoptosis-and-inhibit-sdf-1%C3%AE-induced-bt-549-luc-cell-migration-in-vitro
#12
Chuda Chittasupho, Prartana Kewsuwan, Takashi Murakami
CXCR4 possesses a critical role in several intracellular events such as chemotaxis, invasion and adhesion, which are associated with metastasis of cancer cell. In this study, CXCR4 targeted polymeric nanoparticle was developed for delivering cytotoxic drug and blocking the chemokine induced migration of cells expressing CXCR4. A peptide which was a linear form of CXCR4 antagonist (LFC131) was attached to PLGA nanoparticles (LFC131-NPs) and PLGA nanoparticles encapsulating DOX (LFC131-DOX-NPs). The cellular binding and internalization of LFC131-DOX-NPs were investigated...
February 16, 2017: Current Drug Delivery
https://www.readbyqxmd.com/read/28201966/synthesis-and-biological-evaluation-of-mutual-prodrugs-of-carboxylic-group-containing-some-non-steroidal-anti-inflammatory-drugs-and-propyphenazone
#13
Sucheta Ohlan, Meenu Paliwal, Ruchita Ruchita, Shilpa Jain, Monika Monika, Himanshu Himanshu
Non-steroidal anti-inflammatory drugs (NSAIDs); ketorolac (KA), niflumic acid (NA), tolfenamic acid (TA) were conjugated with propyphenazone derivative 3-Hydroxymethyl propyphenazone (HMP) by direct coupling and by using spacer technique with the objective of obtaining gastro-sparing NSAIDs prodrugs devoid of ulcerogenic side effects. Mutual prodrugs were synthesized and their structures were confirmed and characterized using IR, 1H NMR, 13C NMR, mass spectroscopy and their purity was established by elemental analysis...
February 13, 2017: Current Drug Delivery
https://www.readbyqxmd.com/read/28201965/preparation-and-characterization-of-silymarin-synchronized-and-sustained-release-dropping-pill
#14
Zhi-Hong Liu, Xue-Jing Li, Ai-Wen Huang, Jing Zhang, Hong-Tao Song
PURPOSE: This study aimed to develop a synchronized and sustained-release silymarin dropping pill, and to evaluate its pharmacokinetic characteristics. METHODS: Polyoxyethylene stearate, glyceryl monostearate, and stearic acid were used to prepare the dropping pills. X-ray powder diffraction, differential scanning calorimetry, and release were used to evaluate its physicochemical properties. The plasma concentration of silybin in beagle dogs after oral administration of silymarin dropping pills and silymarin capsule was determined by RP-HPLC...
February 13, 2017: Current Drug Delivery
https://www.readbyqxmd.com/read/28155595/cholinergic-anti-inflammatory-pathway-and-stroke
#15
Kamil Duris, Jolana Lipkova, Michal Jurajda
Stroke is devastating cerebrovascular event which is responsible for 6.7 million deaths each year worldwide. Inflammation plays an important role in the pathophysiology of stroke. Targeting inflammation after stroke is highly actual topic for both experimental and clinical research. Cholinergic anti-inflammatory pathway (CHAIP) is a physiological mechanism by which central nervous system regulates immune response and controls inflammation. Vagus nerve, spleen and α7 nicotinic acetylcholine receptor (α7 nAChR) are the main components of CHAIP...
February 1, 2017: Current Drug Delivery
https://www.readbyqxmd.com/read/28137241/evaluation-of-gentamicin-and-lidocaine-release-profile-from-gum-acacia-crosslinked-poly-2-hydroxyethylmethacrylate-carbopol-based-hydrogels
#16
Baljit Singh, Abhishek Dhiman
In this manuscript an attempt has been made to incorporate both, antibiotic agent 'gentamicin' and pain relieving agent 'lidocaine' into the gum acacia-poly(2-hydroxyethylmethacrylate)-carbopol based hydrogel for wound dressing application. Drug release, gel strength, network parameter, antimicrobial activity and biodegradation properties of hydrogel have been evaluated. Porous microstructure of the hydrogel was observed in cryo-SEM images. The hydrogel showed mesh size 37.29 nm, cross-link density 2.19× 10-5 mol/cm3, molecular weight between two cross-links 60...
January 27, 2017: Current Drug Delivery
https://www.readbyqxmd.com/read/28128069/oral-biodisposition-study-of-ritodrine-after-its-buccal-administration-in-rats
#17
Hiraku Onishi, Kei Yumoto, Osamu Sakata
BACKGROUND: In the previous study, buccal absorption of ritodrine (RD) hydrochloride was reported in vivo. As a result, buccal dosing of RD solution was found to be useful for the maintenance of effective plasma concentration. However, in order to find out the dosing schedule more clearly, it is important to clarify the in vivo drug behavior. OBJECTIVE: The biodistributions of RD in oral cavity and buccal mucosal were investigated in order to understand the in vivo drug behavior after the buccal application...
January 26, 2017: Current Drug Delivery
https://www.readbyqxmd.com/read/28128068/mistletoe-and-garlic-extracts-as-polyurethane-carriers-a-possible-remedy-for-choroidal-melanoma
#18
Melania F Munteanu, Aurel Ardelean, Florin Borcan, Svetlana I Trifunschi, Ramona Gligor, Simona A Ardelean, Dorina Coricovac, Iulia Pinzaru, Florina Andrica, Livia-Cristina Borcan
Melanoma is known as the most dangerous form of skin cancer; whereas the malignant choroidal melanoma is an orphan disease known as the most common primary intraocular malignancy in adults. Literature suggests that the consumption of garlic and/or mistletoe leads to a reduced risk of developing cancer. The obtained microstructures present sizes between 1.05 and 2.60 μm and Zeta potentials between -7 and +36 mV. A good encapsulation was observed on different evaluations (88-92%). It was determined that approx...
January 26, 2017: Current Drug Delivery
https://www.readbyqxmd.com/read/28124617/in-vitro-and-in-vivo-evaluation-of-dmso-and-azone-as-penetration-enhancers-for-cutaneous-application-of-celecoxib
#19
Thassia D Arc Senna, Hilton Antonio Mata Dos Santos, Daniel Mabundu Kibwila, Alvaro Costa Leitão, Alexandre Dos Santos Pyrrho, Marcelo De Pádula, Elaine Cruz Rosas, Tatiana Almeida Pádua, Marilisa Guimarães Lara, Maria Bernadete Riemma Pierre
BACKGROUND: Celecoxib (CXB) has been explored as an anti-inflammatory or chemopreventive drug for topical treatment of skin diseases and cancer. OBJECTIVE: The main aim of this work was to investigate the potential of dimethylsufoxide (DMSO) and Azone (AZ) as penetration enhancers (P.Es) for topical delivery of CXB. METHOD: The in vitro studies, drug release, skin permeability and potential cytotoxicity/genotoxicity were carried out with formulations containing or not DMSO or AZ (5% and 10%)...
January 25, 2017: Current Drug Delivery
https://www.readbyqxmd.com/read/28124616/comparison-of-hcv-core-and-coree1e2-virus-like-particles-generated-by-stably-transfected-leishmania-tarentolae-for-stimulation-of-th1-immune-responses-in-mice
#20
Azam Bolhassani, Noushin Davoudi, Elnaz Agi, Fatemeh Motevalli
Virus-like particles (VLPs) could be improved into successful immunogens as well as a potent delivery vehicle, but however, the current expression systems for VLPs production have some limitations. Recently, we developed a novel strategy to produce two HCV VLPs containing core or coreE1E2 proteins using stably transfected Leishmania tarentolae promastigotes. Then, BALB/c mice were injected by both viral like particles in different immunization strategies such as homologous DNA-, homologous VLP-, and heterologous DNA/ VLP-based immunizations...
January 25, 2017: Current Drug Delivery
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