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Current Drug Delivery

Tapan Kumar Giri
Currently the most important cause of death is cancer. To treat the cancer there are a number of drugs existing in the market but no drug is found to be completely safe and effective. The toxicity of the drugs is the key problem in the cancer chemotherapy. However, plants and plant derived bioactive molecule have proved safe and effective in the treatment of cancers. Phytochemicals that are found in fruits, vegetables, herbs, and plant extract have been usually used for treating cancer. It has been established that several herbal drug have a strong anticancer activity...
September 18, 2018: Current Drug Delivery
Srijita Chakrabarti, Pronobesh Chattopadhyay, Johirul Islam, Subhabrata Ray, Pakalapati Srinivas Raju, Bhaskar Mazumder
Wound infections impose a remarkable clinical challenge that has a considerable influence on morbidity and mortality of patients, resulting in huge impact on economy. The unprecedented advancements in molecular biology have come up with new molecular and cellular targets that can be successfully applied to develop smarter therapeutics against diversified categories of wounds. In the recent years, nanotechnology has achieved a new horizon in the arena of wound care due to its ability to deliver plethora of therapeutics into the target site...
September 18, 2018: Current Drug Delivery
Marilena Vlachou, Stefanos Kikionis, Angeliki Siamidi, Konstantina Tragou, Stefania Kapoti, Efstathia Ioannou, Vassilios Roussis, Andrew Tsotinis
Aiming at the modified release of melatonin (MLT), electrospun-MLT loaded nanofibers, filled into hard gelatin and DRcapsTM capsules, were used as formulants. Cellulose acetate, polyvinylpyrrolidinone and hydroxypropylmethylcellusose (HPMC 2910) were used for the preparation of the fiber matrices through electrospinning. The in vitro modified release profile of MLT from the fabricated matrices in gastrointestinal-like fluids was studied. At pH 1.2, the formulations CA1, CA2, PV1, HP1, HP2 and the composite formulations CAPV1-CAPV5 in hard gelatin capsules exhibited fast MLT release...
September 13, 2018: Current Drug Delivery
Sandra Sherif Amer, Maha Nasr, Wael Mamdouh, Omaima Sammour
Among the common myths in the cosmetics industry is the perception that acne only happens to teenagers, and specifically to females. However, acne is not limited to a specific age, neither to a certain gender, and it creates a stressful problem for many people. Many chemical treatments for acne were proven to be successful, but when administered as such they showed many adverse effects, starting from itching to skin dryness and inflammation. Natural remedies have also been explored for acne treatment, and despite their safety, they suffered many stability problems attributed to their physicochemical properties, creating an obstacle for their topical delivery...
September 13, 2018: Current Drug Delivery
Yongqiang Li, Xiaowei Shi
Effective postoperative pain control is essential for the recovery of surgical patients. However, long-term analgesia can seldom be achieved with the existing medications. The injectable implants prepared by biodegradable polyesters can be conveniently used during the surgery and slowly release analgesics near the operative incision during a long period. In this study, we prepared lidocaine hydrochloride (Lido-HCl)-loaded injectable poly(lactic-co-glycolic acid) (PLGA) implants for prolonged analgesia. The optimized formulation of this injectable implant sustained drug release for up to 5 days, with a cumulative release of 85...
September 12, 2018: Current Drug Delivery
Xiao-Qin Chu, Jie Huang, Zheng-Guang Li, Qian Li, Jiao-Jiao Cao, Jian-Qin Jiang, Shuang-Ying Gui
There has been a growing concern in transdermal drug technology over the past several decades. As a novel transdermal delivery system, Lyotropic liquid crystals (LLC) still face challenges such as drug loading, limited drug permeation and instability of systems. LLC system is so sensitive that a very subtle change in composition may induce a phase transformation or conversion of spatial configuration, and result in a diverse percutaneous delivery subsequently. To find out the effects of hydrophilic and lipophilic components on the structure and transdermal properties of LLCs, hydrophilic sinomenine hydrochloride (SH) and lipophilic cinnamaldehyde (CA) was chosen as a model drug and a skin permeation enhancer, respectively, several formulations were prepared and compared...
September 10, 2018: Current Drug Delivery
Prachi Raikar, B M Gurupadayya, K Venkata Sairam
Chirality is now a key area in the field of research. Researchers are well versed with analytical separations but at the same time are unaware of the growth in the field of chiral separation. According to US FDA guidelines, it is mandatory to separate chiral drugs before they are marketed. Chiral separation is gaining importance in last 10 years due to the differential biological responses of the enantiomers in chiral environment. Identical physical and chemical properties of the enantiomers give a major challenge for the separation of chiral compounds...
August 29, 2018: Current Drug Delivery
Shyamal Kumar Kundu, Chiranjib Chakraborty, Shin Yagihara, Seong Lin Teoh, Srijit Das
Surgical operations are impossible without proper analgesia. Advancement in the field of anesthesia has invariably resulted in the accomplishment of all surgical processes without any inconvenience. A number of different anesthetic materials were found to stimulate anesthesia. These anesthetic molecules stimulate either proteins or lipids in membrane. There is a connection between the anesthetic molecules and the hydrophobic region of the membrane. We attempt to highlight the interaction between the anesthetic molecule with proteins and lipids and their effect...
August 19, 2018: Current Drug Delivery
J Varshosaz, Mahyasadat Jalali, Ali Hosseini Sharifabad
BACKGROUND: Hesperetin (HSP) is a low water soluble flavanone aglycone with low bioavailability. OBJECTIVES: This study aimed at enhancing hepatoprotective effects of HSP by a combinatory technique based on solid dispersions of co-crystals of HSP. METHODS: Co-crystals were prepared using citric acid, tartaric acid, caffeine and isonicotinamide (INM) using two methods of solvent evaporation and co-grinding. Solid dispersion of co-crystals with different ratio of INM, PVP K30 and drug were prepared by the solvent evaporation method...
July 30, 2018: Current Drug Delivery
Parvaneh Saffarian, Abbas Ali Imani Fooladi
Botulinum neurotoxin type A (BoNT/A) is a toxin that inhibits the release of stimulatory neurotransmitter (acetylcholine) at the neuromuscular synapses. In recent years, many patients with muscle contraction disorders have greatly benefited from the therapeutic ability of this biological drug. On the other hand, the injection of this bio drug accompanied with some side effects such as irritation, bruising, inflammation, pain, bleeding at the site of injection which undermines this widely used drug. Recently, there is a tendency among scientists to create new techniques to offers conventional injectable drugs the ability of transdermal delivery...
July 30, 2018: Current Drug Delivery
Emmy Luu, Kevin B Ita, Matthew J Morra, Inna E Popova
It is well documented in the scientific literature that high blood pressure can lead to cardiovascular disease. Untreated hypertension has clinical consequences such as coronary artery disease, stroke or kidney failure. Diltiazem hydrochloride (DH), a calcium-channel blocker, and perindopril erbumine (PE), an inhibitor of the angiotensin converting enzyme are used for the management of hypertension. This project will examine the effect of microneedle rollers on the transport of DH and PE across pig ear skin...
July 30, 2018: Current Drug Delivery
Mehmet Varol, Ayse Tansu Koparal, Kadriye Benkli, Rakibe Beklem Bostancioglu
Drug design and discovery studies still remain of great importance in the search for more convenient chemotherapeutic to avoid the drug resistance, systemic toxicity or the long-term side effects. A series of mononuclear gold (III) and platinum (II) complexes based on 4-dihydroxyboryl-DL-phenylalanine (BPA) was designed and synthesized, for the first time, by using 2, 2'-dipyridyl (L1) and 4, 4'-diaminobibenzyl (L2) ligands. Characterization of the synthesized complexes was achieved by using 1H-NMR, IR, MS and elemental analyses...
July 27, 2018: Current Drug Delivery
Jafar Mosafer, Ahad Mokhtarzadehc
One of the major abundant proteins in nucleous is nucleolin that overexpressed on the cytoplasmic memberance of malignant and endothelial cells and makes it as a promising condidtae for targeted drug delivery. In this atudy, doxorubicin (Dox) as a chemotherapy drug was entrapped into the Poly lactic-co-glycolic acid (PLGA)-based nanoparticles (NPs). Then, the targeting ability of anti nucleolin AS1411 aptamer-targeted Dox-encapsulated PLGA-based NPs (AS1411-NPs) was investigated in high nucleolin-expressing C26 colon carcinoma and rat C6 glioma cell lines compared with low nucleolin-expressing mouse L929 cell line...
July 23, 2018: Current Drug Delivery
Kishan Veerabrahma, Venu Madhav Katla
BACKGROUND: FR&D scientists continuously try to increase the in vivo performance of low soluble and bioavailable drugs. Solid SMEDDS and liquisolid formulations are relatively simple to develop and fall within the novel drug delivery approaches. Here, a comparison is made to know relative superiority. OBJECTIVE: To conduct comparative pharmacokinetic (PK) and pharmacodynamic (PD) studies of developed Fluvastatin (FLU) solid SMEDDS (SSMED) and liquisolid formulation (LS) for their relative in vivo efficacy...
July 22, 2018: Current Drug Delivery
Arezou Soroushnai, Fariba Ganji, Ebrahim Vasheghani-Farahani, Hamid Mobedi
The main objective of this novel study was to develop midazolam hydrochloride Fast dissolving oral films (FDFs) using solvent casting method and to evaluate the characteristics of the optimum formulation through in vitro and in vivo analysis. The FDFs are new favorable solid dosage forms that deliver drugs rapidly to the blood circulation system and have great advantages in the emergent control of severe neuropathic attacks in children.Methods and Midazolam nanosuspensions were prepared using the ultrasonic method and then incorporated in the hydroxypropyl methyl cellulose (HPMC)/pullulan polymeric matrix with other excipients like glycerol and cellulose nanofiber as a softener and a compatibilizer, respectively...
July 22, 2018: Current Drug Delivery
Erick Jose Torres-Martinez, Jose Manuel Cornejo-Bravo, Aracely Serrano-Medina, Graciela Lizeth Perez-Gonzalez, Luis Jesus Villarreal-Gomez
Recently, electrospun polymeric nanofibers have proven to be an interesting strategy for drug delivery systems application. The high surface-to-volume ratio of the fibers can improve some processes, such as cell binding and proliferation, drug loading, and mass transfer processes. One of the most important and studied areas of electrospinning is in the drug delivery field, for the controlled release of active substances ranging from antibiotics and anticancer agents, to macromolecules such as proteins and DNA...
July 22, 2018: Current Drug Delivery
Lakshmi Maurya, Sanjay Singh, Mahalingam Rajamanickam Vijayakumar, Hitesh Kumar Dewangan
BACKGROUND: Vinorelbine bitartrate (VRL) is an antimitotic agent approved by FDA for breast cancer and non-small cell lung cancer (NSCLC) in many countries. However, high aqueous solubility and thermo degradable nature of VRL limited the availability of marketed dosage forms. OBJECTIVES: The current work is focused on the development of lipid based aqueous core nanocapsules which can encapsulate the hydrophilic VRL in the aqueous core of nanocapsules protected with a lipidic shell which will further provide a sustained release...
July 15, 2018: Current Drug Delivery
Shindu C Thomas, Tushar Madaan, Zeenat Iqbal, Sushama Talegaonkar
BACKGROUND: Bendamustine HCl, an antineoplastic drug, has a very short life of about 40 minutes which necessitates administration of large doses which leads to increased side effects as well as costs. OBJECTIVE: The present work describes the fabrication, optimization and evaluation of bioactive hydroxyapatite nanoparticles to achieve sustained delivery of bendamustine HCl. METHODS: Hydroxyapatite nanoparticles (NPs) were prepared by the wet chemical precipitation method by reacting a calcium and phosphate precursor and the reaction was optimized via Box-Behnken DOE...
June 20, 2018: Current Drug Delivery
Diana Edwar Aziz, Aly Ahmed Abdelbary, Abdelhalim Ibrahim Elassasy
BACKGROUND: Niosomes are surfactant-based vesicular nanosystems that proved their efficiency in transdermal delivery by overcoming skin inherent anatomic barrier; startum corneum. Central composite design is an efficient tool for developing and optimizing niosomal formulations using fewer experiments. OBJECTIVE: The objective of this study was to prepare niosomes as a transdermal delivery system of diacerein using film hydration technique, employing central composite design, for avoiding its oral gastrointestinal problems...
June 18, 2018: Current Drug Delivery
Muhammad Ubaid, Syed Nisar Hussain Shah, Shujaat Ali Khan, Ghulam Murtaza
BACKGROUND: In this study, central composite design was utilized for the optimization of genipin cross-linked chitosan/Eudragit®-L 100 interpenetrating hydrogel network films fabricated through solvent evaporation technique. METHODS: Hydrogel formulations were studied using response surface methodology; regression analysis and the surface plots were used to evaluate the effect of variables on T50% (the time for 50% of drug release) and dynamic swelling with optimum formulation selection...
June 3, 2018: Current Drug Delivery
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