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Current Drug Delivery

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https://www.readbyqxmd.com/read/29034838/formulation-optimization-and-evaluation-of-organogel-for-topical-delivery-of-acyclovir
#1
Smita Bonde, Chandrakant Bonde, Nisarg Mavani
BACKGROUND: The conventional acyclovir topical therapy has a low efficacy, due to the lack of penetration of a sufficient amount of drug to the target site. OBJECTIVE: The aim of this work was to formulate and optimize organogel containing acyclovir to enhance the penetration and retention time of acyclovir in the basal epidermis, site of Herpes simplex virus infections. METHODS: Microemulsion based organogel containing acyclovir was developed using the combination of surfactants, polar and nonpolar solvents...
October 13, 2017: Current Drug Delivery
https://www.readbyqxmd.com/read/29034837/dual-purpose-injectable-doxorubicin-conjugated-alginate-gel-containing-polycaprolactone-microparticles-for-anti-cancer-and-anti-inflammatory-therapy
#2
Vaishali Pawar, Vivek Borse, Riya Thakkar, Rohit Srivastava
In situ gel formulations have been widely reported as a carrier for sustained release delivery systems due to certain advantages such as targeted drug delivery, minimal invasiveness and potent therapeutic activity. Herein, in situ gel system for sustained release of doxorubicin and ibuprofen for anti-cancer and anti-inflammatory activity is reported. Doxorubicin-conjugated alginate (dox-alg) gel was prepared using EDC-NHS chemistry and loaded with ibuprofen encapsulated polycaprolactone (PCL) microparticles (dox-alg composite)...
October 13, 2017: Current Drug Delivery
https://www.readbyqxmd.com/read/29034836/nanomedicine-for-intranasal-delivery-to-improve-brain-uptake
#3
Amit A Patel, Ravish J Patel, Shachi R Patel
Intranasal drug delivery system provide distinct advantage over conventional drug delivery system for a drug that is pharmacokenetically or biologically unstable. Major concern for treatment of central nervous system diseases are law concentration of therapeutically active molecule within brain as blood brain barrier is creating obstacle, where intranasal drug delivery provides direct transport of therapeutically active moiety into brain via olfactory or trigeminal pathway. Nasal mucosa provides distinct advantage like improved bioavailability, law dose and quick onset of action and high patient compliance, major disadvantage is residence time of drug and irreversible entrapment of drug...
October 13, 2017: Current Drug Delivery
https://www.readbyqxmd.com/read/29034835/taste-masking-approaches-for-medicines
#4
Waleed Faisal, Fatma Farag, Ahmed A H Abdellatif, Abdelhamid Abbas
Undesirable taste is an important problem for patient compliance. Several oral pharmaceuticals and bulking agents have disagreeable and bitter-tasting components. The Bitter taste characteristics found in such systems have been eliminated or minimized by the development of numerous formulations with improved performance and acceptability especially in children and elderly patient. This review is mainly concerned with the bitter-masking techniques published in peer-reviewed journals and will shed the light on different methods of masking undesirable taste of the drugs, and their pharmaceutical applications...
October 13, 2017: Current Drug Delivery
https://www.readbyqxmd.com/read/28969566/herbal-mixture-adsorbed-to-polyethylene-glycol-microspheres-induces-apoptotic-effects-on-breast-cancer-cells
#5
Aliny Aparecida Lopes Ribeiro, Fabiana Helen da Silva, Aron Carlos de Melo Cotrim, Alessandra Lima Deluque, Patrícia Gelli Feres de Marchi, Danny Laura Gomes Fagundes, Claudia de Sousa Pereira, Eduardo Luzía França, Adenilda Cristina Honorio-França
The combination of medicinal plants and polymeric matrices raised the possibility of obtaining new drugs to treat a number of diseases, including cancer. Breast cancer is one of the most frequent diseases among women, but the effective treatments is still a challenge. Thus, this study investigated the effect of herbal mixture adsorbed to PEG microspheres on MCF-7 human breast cancer cells and these cells in co-culture of blood MN cells. The MCF-7 cells and the blood mononuclear [MN] Cells from volunteer donors...
October 2, 2017: Current Drug Delivery
https://www.readbyqxmd.com/read/28969565/design-and-evaluation-of-transdermal-patches-of-timolol-maleate
#6
S P Hiremath, J Jujjuri, V J Jamakandi
BACKGROUND: Continuous intravenous infusion of controlled drug delivery has certain risks. This could be diligently duplicated devoid of its hassles by using the skin as the port of drug entry. Transdermal drug delivery system is the main route with discrete, self-contained dosage forms when placed on the skin transports the medicament through the skin into the systemic circulation in a well-controlled manner. OBJECTIVE: The rationale of the current work was to formulate and evaluate a transdermal patch of an antihypertensive drug by using different grades of polymers with a view to circumvent the hepatic first pass metabolism and also to escalate its bioavailability...
October 2, 2017: Current Drug Delivery
https://www.readbyqxmd.com/read/28969564/examining-insulin-adsorption-onto-mesoporous-silica-microparticles-for-oral-delivery
#7
Sarah Youssef Eilleia, Mahmoud Eid Soliman, Stefan Niedermayer, Alexandra Schmidt, Samar Mansour, Ahmed Shawky Geneidi
BACKGROUND: Microencapsulation is one of the most common techniques for the delivery of macromolecules; however, it can cause various stability problems, such as degradation or loss of bio-activity of the loaded molecules. For this reason, several techniques were investigated to load insulin into pre-formed porous microparticles (MPs). OBJECTIVE: The high loading of insulin is a prerequisite of its delivery in sufficient concentration; hence we examined insulin loading in mesoporous silica (SBA15-NH2) as a model for uniformly porous microparticles using different loading methods and factors...
October 2, 2017: Current Drug Delivery
https://www.readbyqxmd.com/read/28969554/nanofibers-an-effective-tool-for-controlled-and-sustained-drug-delivery
#8
Amandeep Singh, Goutam Rath, Amit Kumar Goyal
Electrospun nonwoven nanofibers are emerging as a novel carrier for verity of drugs meant for treatment of infections, disorders and tissue engineering scaffolds. These systems may used widely in controlled release of drug that are beneficial for the health management. Nonwoven structures may provide great surface area, absorbable, simplistic processing and economical. For water loving small molecule drugs, their high water solubility and poor partition and compatibility issues with polymers make it long term release yet more challenging...
October 2, 2017: Current Drug Delivery
https://www.readbyqxmd.com/read/28925874/preclinical-assessment-of-steroidal-nanostructured-lipid-carriers-based-gels-for-atopic-dermatitis-optimization-and-product-development
#9
Upendra Nagaich, Neha Gulati
BACKGROUND: Betamethasone Valerate (BV) is potent topical corticosteroid. Preparation of nanostructured lipid carreirs (NLC) involves process parameters optimization and formulations were developed. It is available in several conventional formulations like creams and ointments which have well-known problems of frequent dosing and consequently additional side effects. The aim is to ascertain the probability of NLC as an exclusive carrier for betamethasone valerate topical application with regard to release modulation and improved therapeutic effect...
September 18, 2017: Current Drug Delivery
https://www.readbyqxmd.com/read/28925873/silver-nanoparticles-with-high-loading-capacity-of-amphotericin-b-characterization-bactericidal-and-antifungal-effects
#10
Victoria Leonhard, Roxana Valeria Alasino, Adrián Muñoz, Dante Miguel Beltramo
The purpose of this study was to evaluate the most appropriate conditions to generate silver nanoparticles (AgNPs) loaded with a potent antimycotic drug like amphotericin B (AmB), characterize the physicochemical properties, and also evaluate the cytotoxic effect and biological activity of these new nanostructures as a potential nanocarrier for hydrophobic drugs. It was determined that the optimal molar ratio between Ag and AmB is 1/1 given the uniformity of size around 1750 nm of the nanoparticles generated as well as their strongly negative ζ potential of -27 mV, a condition that favors repulsions between AgNPs and inhibiting their aggregation...
September 18, 2017: Current Drug Delivery
https://www.readbyqxmd.com/read/28847274/nano-era-of-dentistry-an-update
#11
Paramjot Maman, Manju Nagpal, Ritu Mehra Gilhotra, Geeta Aggarwal
BACKGROUND: Management of the health of oral tissues is a prime requirement in dentistry. The prevention of tooth decay and the treatment of lesions and cavities are ongoing challenges. The limitations in dental materials, medications, instruments, procedures put off the accomplishment of this goal. Rationalization of science and technology has made possible to work out these limitations. Nanotechnology which is the outcome of this rationalization has become one of the most favored technologies in medical and dental application...
August 25, 2017: Current Drug Delivery
https://www.readbyqxmd.com/read/28847273/copaiba-oil-chemical-composition-and-influence-on-in-vitro-cutaneous-permeability-of-celecoxib
#12
Oliesia Gonzalez Quiñones, Renata Pereira Abranches, Marcos Jun Nakamura, Mônica Freiman de Souza Ramos, Maria Bernadete Riemma Pierre
BACKGROUND: Use of topical or transdermal administration of Celecoxib (Cxb) is an interesting strategy in cutaneous treatments since it reduces or avoids side effects of the oral route. However, Cxb´s high lipophilicity and the stratum corneum (SC) barrier impair cutaneous penetration. OBJECTIVE: evaluate copaiba oil (C.O) as a potential skin penetration enhancer (P.E) for Cxb. METHODS: The chemical composition of C.O was evaluated by GC-MS...
August 25, 2017: Current Drug Delivery
https://www.readbyqxmd.com/read/28847272/oral-vaccination-through-peyer-s-patches-update-on-particle-uptake
#13
Edna Soares, Olga Borges
Oral immunization has numerous advantages over parenteral administrations. In addition to ease administration, more effective pathogen elimination on the mucosa before spreading into the blood circulation, constitutes the main benefit. This is particularly true for pathogens that enter the body through the oral route. On the other hand, it is the most challenging administration route for peptides, proteins and recombinant antigens due to gastrointestinal (GI) tract numerous barriers including the harsh environment and the inherent weak immunogenicity...
August 25, 2017: Current Drug Delivery
https://www.readbyqxmd.com/read/28847271/influence-of-divalent-cation-on-morphology-and-drug-delivery-efficiency-of-mixed-polymer-nanoparticles
#14
Ramachandran Deepika, Koyeli Girigoswami, Ramachandran Murugesan, Agnishwar Girigoswami
Biopolymeric nanoparticles comprising chitosan-alginate have attracted interest in drug delivery due to their protective nature, biocompatibility, biodegradability and hydrophilicity. The present study was designed to encapsulate levofloxacin in chitosan-alginate hybrid gel for controlled release and to evaluate the effect of divalent alkaline earth metal ions (Mg2+, Ca2+, Sr2+, Ba2+) on encapsulation efficiency and drug release kinetics considering their role in polyelectrolyte gelation method. Divalent metal ions control the rigidity and elasticity of the hydrogels and have ability to change the shape and size of nanostructure formed by chitosan-alginate...
August 25, 2017: Current Drug Delivery
https://www.readbyqxmd.com/read/28745230/bupivacaine-s75-r25-loaded-in-nanostructured-lipid-carriers-factorial-design-hplc-quantification-method-and-physicochemical-stability-study
#15
Gustavo Henrique Rodrigues Da Silva, Ligia Nunes de Moraes Ribeiro, Viviane Guilherme, Simone Ramos de Castro, Márcia Cristina Breitkreitz, Eneida de Paula
Bupivacaine is the most used local anesthetic in surgical procedures, producing prolonged anesthesia. The major limiting factor for the clinical use of bupivacaine comes from its systemic toxicity. Nanostructured lipid carriers (NLC) are vehicles for sustained drug delivery that are able to minimize the toxicity and to increase the action time of lipophilic drugs. This work reports a 22 factorial design, which elucidate the role of the lipids mixture in the NLC, towards an optimized formulation. It also provides a new method for Bupivacaine S75:R25 (BVCS75) quantification in NLC...
July 26, 2017: Current Drug Delivery
https://www.readbyqxmd.com/read/28745229/delivering-resveratrol-on-the-buccal-mucosa-using-mucoadhesive-tablets-a-potential-treatment-strategy-for-inflammatory-oral-lesions
#16
Isadora Conde Ferreira Martins, Nádia Rezende Barbosa Raposo, Hanny Reis Mockdeci, Hudson Caetano Polonini, Anderson de Oliveira Ferreira, Gisele Maria Campos Fabri, Maria das Graças Afonso Miranda Chaves
Resveratrol is a polyphenol which has been gaining momentum in therapeutics in the last years. In this work, we hypothesized that it could act in the prophylaxis and/or treatment of inflammatory lesions of the oral cavity through its delivery from two different formulations of buccal mucoadhesive tablets. This was assessed through permeation studies, in order to verify the drug diffusivity through the buccal mucosa, using a porcine model to predict the human in vivo behavior. We observed that the tablet with a lower percentage of viscosity agents delivered more resveratrol, although a large amount of the drug was found retained within the stratum corneum...
July 26, 2017: Current Drug Delivery
https://www.readbyqxmd.com/read/28745228/advances-in-the-delivery-of-cancer-therapeutics-a-comprehensive-review
#17
Gunjan Jeswani, Swarnali Das Paul, Arvind Kumar Jha
BACKGROUND: The effects of various chemotherapeutic agents have been assessed for their capacity to inhibit the cell replication in variety of cancer cases. At present there are more than hundred chemotherapeutic agents capturing worth 42 billion dollar of drug market. The major obstacle in the successful treatment of cancer is the obnoxious side effects of chemotherapeutics and multi drug resistance, which deteriorates the quality of life of cancer patient. OBJECTIVE: This article attempts to summarize different novel chemotherapeutic delivery systems which aim to circumvent these unwanted effects...
July 26, 2017: Current Drug Delivery
https://www.readbyqxmd.com/read/28721817/improvement-of-thermosensitive-liposome-stability-by-cerasome-forming-lipid-with-si-o-si-network-structure
#18
Qin Su, Ximing Pu, He Bai, Xianchun Chen, Xiaoming Liao, Zhongbing Huang, Guangfu Yin
BACKGROUND: Liposomes have been widely used in the gene transfection and the drug delivery systems due to their excellent biocompatibility and encapsulation ability, especially, the ability to deliver the gene/drug into the cells via the membrane fusion. Thermosensitive liposoems have been proven to be a precise and effective method for cancer treatment in many preclinical studies. But the imperfect crystalline arrangement between grains occurred, resulting in planar defects at the boundaries of membranes, compromising the stability of thermosensitive liposomes...
July 19, 2017: Current Drug Delivery
https://www.readbyqxmd.com/read/28721816/plga-nanoparticles-and-polysorbate-80-coated-plga-nanoparticles-increase-in-the-vitro-antioxiant-activity-of-melatonin
#19
Leiziani Gnatkowski Martins, Najeh Maissar Khalil, Rubiana Mara Mainardes
Melatonin is an endogen substance with several physiological functions, acting as an important antioxidant. Our objective was to prepare nanoparticles composed of poly(lactic-co-glycolic acid) (PLGA) coated with polysorbate 80 (PLGA-PS80) or uncoated (PLGA) nanoparticles containing melatonin (MLT) and evaluate their in vitro cytotoxicity over erythrocytes and in vitro antioxidant activity. Nanoparticles were obtained by an emulsion-solvent evaporation method and characterized by size, morphology, polydispersity index, zeta potential, encapsulation efficiency, thermal properties and in vitro drug release profile...
July 19, 2017: Current Drug Delivery
https://www.readbyqxmd.com/read/28707580/doxorubicin-loaded-micelle-targeting-muc1-a-potential-therapeutics-for-triple-negative-breast-cancer-treatment
#20
Supang Khondee, Chuda Chittasupho, Singkome Tima, Songyot Anuchapreeda
BACKGROUND: Triple negative breast cancer (TNBC) is an aggressive disease associated with poor prognosis and lack of validated targeted therapy. Thus chemotherapy is a main adjuvant treatment for TNBC patients, but it associates with severe toxicities. For a better treatment outcome, we developed an alternative therapeutic, doxorubicin (DOX)-loaded micelles targeting human mucin1 protein (MUC1) that is less toxic, more effective and targeted to TNBC. METHODS: From many candidate peptides, QNDRHPR-GGGSK (QND) and HSQLPQV-GGGSK (HSQ), were identified computationally, synthesized and purified using solid phase peptide synthesis and semi-preparative HPLC...
July 12, 2017: Current Drug Delivery
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