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Current Drug Delivery

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https://www.readbyqxmd.com/read/28034362/araucaria-gum-novel-natural-polymer-for-controlled-drug-delivery-development-in-vitro-and-in-vivo-evaluation-of-araucaria-gum-based-matrix-tablets-for-controlled-release
#1
Divvela Hema Naga Durga, Venkata Ramana Murthy Kolapalli, Duppala Lohithasu
CONTEXT: Assessment of natural polymers in oral controlled drug delivery. OBJECTIVE: The objective of the present investigation was to the assessment of Araucaria gum (AHG) obtained from bark exudates of the Araucaria heterophylla (family: Araucariaceae) for the design of oral controlled release forms, in particular tablet dosage forms by using matrix systems. Diclofenac sodium was used as model drug and compared with the marketed formulation. METHODS: Matrix tablets were prepared by wet granulation technique and 5% w/v of AHG dispersion water was used as granulating agent for preparation of AHG matrix tablets...
December 30, 2016: Current Drug Delivery
https://www.readbyqxmd.com/read/28034361/formulation-and-optimization-of-candesartan-cilexetil-nano-lipid-carrier-in-vitro-and-in-vivo-evaluation
#2
Anjan Paudel, EmptyYN Y Ameeduzzafar, Syed Sarim Imam, Abdul Hafeez, Mohd Fazil, Shahroz Khan, Farhan Jalees Ahmad, Asgar Ali
PURPOSE: The objective of this study was to formulate and optimize Candesartan Cilexetil (CC) loaded nanostructured lipid carriers (NLCs) for enhanced oral bioavailability. METHOD: Glycerol monostearate (GMS), Oleic acid, Tween 80 and Span 40 were selected as a solid lipid, liquid lipid, surfactant and co- surfactant, respectively. The CC-NLCs were prepared by hot emulsion probe sonication technique and optimized using experimental design approach. The formulated CC-NLCs were evaluated for various physicochemical parameters and further optimized formulation (CC-NLC-Opt) was assessed for in-vivo pharmacokinetic and pharmacodynamic activity...
December 30, 2016: Current Drug Delivery
https://www.readbyqxmd.com/read/28034360/role-of-nanoparticles-in-drug-delivery-and-regenerative-therapy-for-bone-diseases
#3
Sonia Gera, Sunitha Sampathi, Sujatha Dodoala
Osteoporosis (OP) is a disease characterized by progressive bone loss due to aging and menopause in women leading to bone fragility with increased susceptibility towards fractures. The silent disease weakens the bone by altering its microstructure and mass. Therapy is based on either promoting strength (via osteoblast action) or preventing disease (via osteoclast action). Current therapy with different drugs belonging to antiresorptive, anabolic and hormonal classification suffers from poor pharmacokinetic and pharmacodynamic profile...
December 30, 2016: Current Drug Delivery
https://www.readbyqxmd.com/read/28000552/studies-of-kp46-and-kp1019-and-the-hydrolysis-product-of-kp1019-in-lipiodol-emulsions-preparation-and-initial-characterizations-as-potential-theragnostic-agents
#4
Berta Cebrián Losantos, Irena Pashkunova-Martic, Norbert Kandler, Bernhard Keppler
OBJECTIVE: In this pilot study, we made use of Lipiodol as a potential carrier of three promising antitumor metal complexes (tris(8-quinolato)gallium(III) (KP46), tetrachlorobis(indazole)ruthenate(III) (KP1019) and the hydrolysis product of KP1019, mer,trans-[RuCl3(H2O)(Hind)2]. METHOD: The stability of the drugs in Lipiodol and the release profile into the aqueous phase were examined independently by three different analytical techniques (high pressure liquid chromatography, HPLC; atom absorption spectroscopy, AAS; and electron spray ionization mass spectrometry, ESI-MS)...
December 20, 2016: Current Drug Delivery
https://www.readbyqxmd.com/read/27919213/characteristics-and-performance-of-flurbiprofen-8-75-mg-spray-for-sore-throat
#5
David Veale, Adrian Shephard, Verity Adams, Charlotte Lidster
BACKGROUND: Sore throat sprays provide targeted relief by delivering the active ingredient directly to the site of pain. Although there are several throat sprays available, they vary with respect to the spray characteristics, thus affecting delivery of the active ingredient to the throat as well as more functional attributes of the product, which have the potential to impact compliance. OBJECTIVE: The characteristics and performance of flurbiprofen 8.75 mg sore throat spray were compared with 12 other sprays...
December 5, 2016: Current Drug Delivery
https://www.readbyqxmd.com/read/27919212/investigating-drug-repositioning-approach-to-design-novel-prodrugs-for-colon-specific-release-of-fexofenadine-for-ulcerative-colitis
#6
Suneela S Dhaneshwar, Priyanka Singh
BACKGROUND: Recent immunologic data implicates involvement of mucosal immune cells of the intestine like eosinophils and mast cells to be functionally involved in the pathogenesis of UC. Mast cell activation is followed by increased secretion and elevated tissue concentration of histamine. Inhibition of mucosal histamine release in colon may be an effective therapeutic approach to treat UC. Some studies report that intestinal inflammation associated with acute and chronic colitis has been ameliorated by fexofenadine in mice...
December 5, 2016: Current Drug Delivery
https://www.readbyqxmd.com/read/27889994/pd-1-pd-ls-a-new-target-for-regulating-the-immunopathogenesis-in-central-nervous-system-disorders
#7
Jie Wu, Zhengquan Yu, Gang Chen
The central nervous system (CNS) was traditionally thought to tolerate inflammatory responses. However, CNS is not completely immune-privileged in recent researches. These responses including Microglia and macrophage activation and peripheral immune cells infiltration have been founded successively. Thus, the traditional view of the adult brain as an immune-privileged organ has been changed. Increasing evidence indicated that the PD-1(programmed cell death-1)/PD-Ls signal pathway plays an important role in regulating the immunopathogenesis of brain following injury...
November 23, 2016: Current Drug Delivery
https://www.readbyqxmd.com/read/27875950/targeted-delivery-of-cabazitaxel-by-conjugation-to-albumin-peg-folate-nanoparticles-using-a-cysteine-acrylate-linker-and-simple-synthesis-conditions
#8
Mohammad Kazem Khoeeniha, Mehdi Esfandyari-Manesh, Hossein Behrouz, Mohsen Amini, Behrang Shiri Varnamkhasti, Fatemeh Atyabi, Rassoul Dinarvand
Cabazitaxel (CBZ) is a new taxane approved by the FDA for treatment of castration-resistant prostate cancer not responding to docetaxel. However, CBZ is not a suitable substrate for p-glycoprotein 60, an efflux pump which transports anticancer drugs out of malignant cells and is therefore a promising drug for treatment of multidrug resistant tumors. Similar to other taxanes, the presence of Tween 80 in the CBZ formulation shows that it is insoluble in water. Therefore, to increase the solubility and circulation time, a CBZ-albumin conjugate was synthesized...
November 22, 2016: Current Drug Delivery
https://www.readbyqxmd.com/read/27848883/osteopontin-as-a-potential-therapeutic-target-for-ischemic-stroke
#9
Qiquan Zhu, Xu Luo, Yun Liu, Jie Zhang, Hansheng Luo, Qin Huang, Yuan Cheng, Zongyi Xie
Ischemic stroke is the third leading cause of death and the most frequent cause of permanent disability in adults worldwide. Tremendous advances have been made in understanding of the pathophysiology of cerebral ischemia, however, there is still no effective neuroprotectant available in the clinical work. Osteopontin (OPN), a multifunctional protein, has been shown to participate in multiple pathophysiological processes of various system diseases, including ischemic brain injury. Mounting evidence indicates that OPN attenuates cerebral damage in ischemic stroke, and possesses multiple neuroprotective effects via diverse signaling pathways...
November 16, 2016: Current Drug Delivery
https://www.readbyqxmd.com/read/27834147/sestrins-a-new-kid-for-stroke-treatment
#10
John H Zhang, Xudan Shi, Liang Xu, Jay Malagult, Jiping Tang, Min Yan
The sestrin family includes several conserved stress-induced proteins that contribute to the maintenance of homeostasis, DNA stability and cell viability in response to various types of injuries. It is well established that the protective functions of AMP-dependent protein kinase (AMPK) and/or mammalian target of rapamycin (mTOR) are regulated by sestrins. Additionally, it has been revealed that sestrins are able to protect cells from oxidative stress by scavenging reactive oxygen species (ROS). The essential involvement of sestrins in mTORC1 inhibition and ROS scavenging signaling pathway, which modulate metabolism homeostasis and regulate autophagy, indicates that sestrins may serve as a potential agent for cell growth, development, metabolism, and neurodegenerative disorders...
November 11, 2016: Current Drug Delivery
https://www.readbyqxmd.com/read/27834152/research-problems-associated-with-resveratrol-trans-3-5-4-trihydroxystilbene-rsv-and-various-strategies-to-overcome-those-problems-review
#11
Monika, Garg R, Sardana S K
BACKGROUND: Resveratrol belonging to stilbene family has emerged as a leading candidate for enhancing the health span by potentially decreasing the aging process and reducing chronic diseases. OBJECTIVE: The aim of this review is to focus on various studies related to chemical composition l, pharmacological activities, bioavailability problems associated with resveratrol. In addition, it includes section discussing the challenges associated with drug and strategies to improve resveratrol solubility, stability and bioavailability...
November 9, 2016: Current Drug Delivery
https://www.readbyqxmd.com/read/27834151/in-vitro-and-in-vivo-performance-of-novel-spray-dried-andrographolide-loaded-scleroglucan-based-formulation-for-dry-powder-inhaler
#12
Ashwin J Mali, C Bothiraja, Ravindra R Purohit, Atmaram P Pawar
Current therapy for pulmonary arterial hypertension (PAH) is unable to prevent progression of disease due to continuous infusions and multiple oral administrations. This resulted in the need of novel treatment which would target directly structural vascular changes that weaken blood flow through pulmonary circulation. The objective of present study was to develop spray dried (SD) formulation for dry powder inhaler (DPI) with enhanced aerosol performance and lung deposition by using novel bioactive, andrographolide (AGP) and carrier, scleroglucan (SCLG) with improved antihypertensive activity...
November 9, 2016: Current Drug Delivery
https://www.readbyqxmd.com/read/27834150/intranasal-delivery-of-microspheres-loaded-with-20-r-ginsenoside-rg3-enhances-anti-fatigue-effect-in-mice
#13
Wei Zhang, Xiaoyu Wang, Min Zhang, Min Xu, Wenyan Tang, Yi Zhang, Lei Lu, Jing Gao, Shen Gao
Nasal delivery of 20 (R) -ginsenoside Rg3 (Rg3) has a short-lived anti-fatigue effect owing to rapid clearance by nasal cilia. Thus, in order to extend the residence time of Rg3 in the nasal cavity, a new drug delivery system is needed. Chitosan microspheres loaded with Rg3 were prepared using a multi-step emulsification method. They had a spherical shape with a mean diameter of 44.9±12.6 µm. The drug-loading ratio was 10.25±0.08%, and the encapsulation ratio was 30.61±1.46%. Our in vitro mucoadhesion experiment demonstrated that 70...
November 9, 2016: Current Drug Delivery
https://www.readbyqxmd.com/read/27834149/development-and-evaluation-of-high-bioavailable-sustained-release-nimodipine-tablets-prepared-with-monolithic-osmotic-pump-technology
#14
Hua Kong, Fanglin Yu, Yan Liu, Yangyang, Mingyuan Li, Xiaohui Cheng, Xiaoqin Hu, Xuemei Tang, Zhiping Li, Xingguo Mei
BACKGROUND: Frequent administration caused by short half-life and low bioavailability due to poor solubility and low dissolution rate limit the further application of poorly water-soluble nimodipine although several new indications have been developed. To overcome these shortcomings, sophisticated technologies had to be used since the dose of nimodipine is not too low and the addition of solubilizers couldn't resolve the problem of poor release. OBJECTIVE: The purpose of this study was to obtain sustained and complete release of nimodipine with a simple and easily industrialized technology...
November 9, 2016: Current Drug Delivery
https://www.readbyqxmd.com/read/27834148/the-role-of-nuclear-receptor-ppar%C3%AE-in-the-sleep-wake-cycle-modulation-a-tentative-approach-for-treatment-of-sleep-disorders
#15
Eric Murillo-Rodriguez
There is a general consensus that sleep-wake cycle is controlled by neuroanatomical, neurochemical and molecular systems as well as by homeostatic and circadian complex networks. The research has shown that a molecular element that could be displaying a relevant role in the modulation of sleep is the peroxisome proliferator-activated receptor alpha (PPARα), which belongs to the family of nuclear receptor ligand-activated transcription factors that includes PPARβ/δ and PPARγ. A growing body of evidence supports the notion that PPARα is activated by natural ligands such as the anorexic lipid mediator oleoylethanolamide (OEA) or synthetic compounds including Wy14643 whereas antagonists like MK-886 block the neurobiological outcomes of PPARα...
November 9, 2016: Current Drug Delivery
https://www.readbyqxmd.com/read/27784210/the-updated-role-of-oxidative-stress-in-subarachnoid-hemorrhage
#16
Yang Yang, Sheng Chen, Jianmin Zhang
Subarachnoid hemorrhage (SAH) is a ruinous disease with high morbidity and mortality. Two areas are becoming research hotspots of this disease: early brain injury (EBI) and delayed vasospasm. There is substantial evidence suggesting that oxidative stress plays a key role in the development of EBI and delayed cerebral vasospasm after SAH. Previous studies show several sources for the excessive generation of free radicals after SAH, such as disrupted mitochondrial respiration, upregulated enzymatic pathways and extracellular hemoglobin degradation...
October 25, 2016: Current Drug Delivery
https://www.readbyqxmd.com/read/27784211/development-of-salbutamol-sulphate-sublingual-films-in-pullulan-matrix-for-enhanced-bioavailability-clinical-efficacy
#17
Nahed Sallam, Rania Sanad, Rasha Kharshoom, Mokhles Zeneldin
BACKGROUND: Salbutamol sulphate (SS) is a model short-acting β2-adrenergic receptor agonist used for the relief of bronchospasm having poor bioavailability (50%) due to its extensive first-pass effect. OBJECTIVE: Formulation of SS as fast dissolving sublingual films (FDSFs) using a biocompatible and biodegradable Pullulan polymer to bypass its metabolism in liver and offers a fast relieve of asthma. METHOD: Films were prepared by solvent casting technique adopting 32 factorial design to study the effect of two independent variables namely; polymer type (HPMC E5, Pullulan, and L-HPC) and polymer to Maltodextrin ratio (3:0, 3:1 or 5:1)...
October 24, 2016: Current Drug Delivery
https://www.readbyqxmd.com/read/27774882/sol-gel-derived-warfarin-silica-composites-for-controlled-drug-release
#18
Ekaterina S Dolinina, Elena V Parfenyuk
BACKGROUND: Warfarin, commonly used anticoagulant in clinic, has serious shortcomings due to its unsatisfactory pharmacodynamics. One of efficient ways of improvement of pharmacological and consumer properties of drugs is development of optimal drug delivery systems. OBJECTIVE: The aim of this work is synthesis of novel warfarin - silica composites and study in vitro the drug release kinetics to obtain the composites with controlled release. METHODS: The composites of warfarin with unmodified (UMS) and mercaptopropy modified silica (MPMS) were synthesized by sol-gel method...
October 21, 2016: Current Drug Delivery
https://www.readbyqxmd.com/read/27839504/nanoparticle-modified-drug-loaded-biodegradable-polymeric-contact-lenses-for-sustainable-ocular-drug-delivery
#19
Ravi Shankaran Dhesingh, Mridula Prakash
Glaucoma, a chronic eye condition caused by progressive degeneration of retinal ganglion cells results in permanent blindness. The restricted efficiency of currently available glaucoma treatments has awakened a global need for designing a novel anti-glaucoma drug delivery mechanism that targets the drug to the site of action in a sustained manner with less toxicity and side effects. With reference to this global problem in the present study, we have fabricated a biodegradable transparent polymeric material loaded with minimum amount of anti-glaucoma drug, acetazolamide...
October 18, 2016: Current Drug Delivery
https://www.readbyqxmd.com/read/27758693/assessment-of-poly-vinyl-alcohol-coated-flutamide-nanoparticulates-and-their-efficacy-on-prostate-cancer-cells
#20
R S Surenya, K S Snima, V Nair Shantikumar, Vinoth Kumar Lakshmanan
Flutamide (FLT) is a non steroidal antiandrogenic drug used to treat prostate cancer. Its poor aqueous solubility and toxicity are the major hindrance for oral drug delivery. The nanoformulation of flutamide increases its aqueous solubility thereby improves the therapeutic efficacy of the chemodrug. Poly (vinyl alcohol) (PVA) coated flutamide nanoparticles (PVA FLT NPs) were formulated by nanoprecipitation method and characterized by DLS, TEM and FTIR. The nanoparticles were about 300nm size and spherical in shape...
October 18, 2016: Current Drug Delivery
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