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Current Drug Delivery

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https://www.readbyqxmd.com/read/28521675/chemotherapy-with-si-rna-and-anti-cancer-drugs
#1
Kamaljeet Kaur, Goutam Rath, Saket Chandra, Ranjit Singh, Amit K Goyal
To treat cancer, chemotherapy is a key therapeutic approach which is associated with several limitations. This chemotherapeutical agents exhibit multi drug resistance coupled with undesirable side effects. This multidrug resistance is exhibited by tumor cell due to actuation of drug out flow mechanism, programmed cell death and protection mechanisms etc. One of the therapeutic approaches to cure cancer is RNA interference (RNAi). Small interfering RNA (si-RNA) is considered as a major therapeutic tool used to control expression of a particular gene...
May 18, 2017: Current Drug Delivery
https://www.readbyqxmd.com/read/28521674/sorbitane-monostearate-and-cholesterol-based-niosomes-for-oral-delivery-of-telmisartan-from-bench-to-preclinical-implementation-in-wistar-albino-rats
#2
Abdul Ahad, Mohammad Raish, Fahad I Al-Jenoobi, Abdullah M Al-Mohizea
BACKGROUND: Niosomes are non-ionic surfactant vesicles used as drug carriers for encapsulating both hydrophobic and hydrophilic drugs. The aim of the present study was to prepare and characterize niosomes formulations for oral delivery of telmisartan and evaluated for its antihypertensive activity. METHOD: Telmisartan loaded niosomes were prepared using thin film hydration method by varying the Span 60 and cholesterol at several molar ratios and characterized for vesicles size, polydispersity index, zeta potential, entrapment efficiency...
May 18, 2017: Current Drug Delivery
https://www.readbyqxmd.com/read/28521673/simple-strategy-to-protect-lactase-activity-in-solid-formulation
#3
Aline Gravinez Perissinato, André Luis Morais Ruela, Gislaine Ribeiro Pereira, Jerusa Simone Garcia, Marcello Garcia Trevisan
Lactose intolerance is characterized by the absence of the enzyme lactase (beta-galactosidase) and affects two thirds of the world adult population. Our aim was to evaluate a lactase gastro formulation to ensure increased activity in the action site of the enzyme (lumen of the small intestine). Simultaneously, we also evaluated the commercial product stability and enzyme activity. When carrying out dissolution test in commercial product it is noted that the existing formulation is not able to protect the enzyme from degrading action of gastric environment (a loss of 86...
May 18, 2017: Current Drug Delivery
https://www.readbyqxmd.com/read/28521697/an-accelerated-release-method-of-risperidone-loaded-plga-microspheres-with-good-ivivc
#4
Hu Xiaoqin, Jianwei Zhang, Xuemei Tang, Mingyuan Li, Siyu Ma, Cheng Liu, Gao Yue, Yue Zhang, Yan Liu, Fanglin Yu, Yang Yang, Guo Jia, Zhiping Li, Xingguo Mei
The purpose of this study was to obtain an accelerated release method of risperidone loaded poly(lactic-co-glycolic acid) (PLGA) microspheres with good in vitro/in vivo correlation (IVIVC). Two formulations of risperidone loaded PLGA microspheres used for evaluating IVIVC were prepared by O/W method. The accelerated release condition was optimized by investigating the effect of pH, osmotic pressure, temperature and ethanol concentration on the release of risperidone from microspheres and the in vitro accelerated release profiles of risperidone from PLGA microspheres were obtained under this optimized accelerated release condition...
May 15, 2017: Current Drug Delivery
https://www.readbyqxmd.com/read/28521696/nanotechnology-as-a-promising-strategy-for-anticancer-drug-delivery
#5
Mona Basha
Cancer was and still a very stressful and urgent disease condition representing a leading cause of death in developed as well as developing countries. Although, much research work in both medical and pharmaceutical fields has evolved in the past few years in addition to some promising clinical trials and few market products, cancer becomes much wilder, threatening and getting more lives. Most approaches have focused on the synthesis of new active ingredients or chemical modification of available ones, formulating them in suitable dosage forms aiming for targeted and effective drug delivery with minimal side effects...
May 15, 2017: Current Drug Delivery
https://www.readbyqxmd.com/read/28482784/recent-advancemnts-in-biodegradable-ocular-implants
#6
Oshin Miranda, Swati Mittal
The perpetuation of healthy vision is paramount in an individual. It has been observed that various drug delivery systems are been fabricated to develop vision quality in individuals. Systemic ocular drug therapies have limited efficacy due to poor bioavailability, systemic and toxic side effects and low patient compliance. Various drug systems which follow the ocular route of administration are manufactured to achieve optimized bioavailability along with better patient compliance. Ocular implants is one such example...
May 7, 2017: Current Drug Delivery
https://www.readbyqxmd.com/read/28472909/impact-of-surfactants-on-skin-penetration-of-dexpanthenol
#7
Flavia Laffleur, Stefan Pschick, Jan Barthelmes, Sabine Hauptstein, Andreas Bernkop-Schnürch
OBJECTIVE: It was the aim of this study to evaluate the impact of nonionic and ionic surfactants on skin penetration of dexpanthenol. METHODS: The relative potency of three surfactants (two nonionic and one ionic) as enhancers in the permeability of a series of compounds was investigated. The influence of the enhancers was also studied. For this purpose porcine abdominal skin was prepared and mounted on Franz diffusion cells, while different mixtures of Dexpanthenol containing Tween®85, SDS and Span®80 in concentrations of 0...
May 3, 2017: Current Drug Delivery
https://www.readbyqxmd.com/read/28472908/targeted-nanostructured-lipid-carriers-for-delivery-of-paclitaxel-to-cancer-cells-preparation-characterization-and-cell-toxicity
#8
Mahboubeh Rezazadeh, Jaber Emami, Farshid Hassanzadeh, Hojjat Sadeghi, Mahboubeh Rostami, Hamid Mohammadkhani
Low water solubility, high systemic toxicity and insignificant cellular uptake has limited efficient clinical applications of the anti-tumor agent paclitaxel (PTX). To overcome these limitations, a novel nanostructured lipid carrier (NLC) modified with folic acid (FA) and polyethylene glycol (PEG) was prepared by emulsion solvent evaporation method using cholesterol, α-tocopherol, lecithin and Poloxamer. A partial factorial design was applied to determine the appropriate levels of variables for optimized formulation...
May 3, 2017: Current Drug Delivery
https://www.readbyqxmd.com/read/28425869/development-of-a-chitosan-based-nanoparticle-formulation-for-ophthalmic-delivery-of-honokiol
#9
Feng Deng, Wenjing Hu, Huali Chen, Yalan Tang, Liangke Zhang
In this study, honokiol-loaded chitosan/sulfobutylether-β-cyclodextrin nanoparticles (HK-CS-NPs) were prepared for ophthalmic drug delivery systems. An inclusion complex of honokiol and sulfobutylether-β-cyclodextrin was used to generate large amounts of insoluble honokiol to be incorporated into chitosan nanoparticles, which were prepared through ionotropic gelation. HK-CS-NPs featured a spherical surface with a narrow size distribution of polydispersity index less than 0.250, a mean size range of 373-523 nm, a positive surface charge of +19...
April 19, 2017: Current Drug Delivery
https://www.readbyqxmd.com/read/28530536/leuprolide-acetate-release-study-from-%C3%AE-irradiated-plga-based-in-situ-forming-system
#10
Mona Shapourgan, Hamid Mobedi, Nasrin Sheikh, Aliasghar Behnamghader, Arezou Mashak
It is well known that the properties of polymers can be altered by exposure to γ- ray. γ-irradiation has been used as a sterilization method for biodegradable polymeric drug delivery devices, and its drug release profile must not be significantly changed. In this study, the effect of γ-irradiation with 8 kGy doses on the release profile of leuprolide acetate from PLGA-based in situ forming system was evaluated. PLGA-based in situ forming systems were prepared by injecting some specific amount of irradiated solution of PLGA /NMP containing drug into a buffer phosphate pH 7...
March 28, 2017: Current Drug Delivery
https://www.readbyqxmd.com/read/28322165/anti-inflammatory-and-anti-arthritic-activity-of-different-milk-based-formulation-of-curcumin-in-rat-model
#11
Sumeet Gupta
Inflammation is the key mediator for arthritis. Plant based products are most useful for treating various disorders, but at the same time drug absorbtion is utmost important for effective therapy. The aim of the study was to find out the therapeutic concern in pharmacokinetic and pharmacodynamic parameters in an arthritis induced rat model. Carrageenan and complete Freud's adjuvant, both were used for an arthritis induction as an animal model. Five different formulations of curcumin were prepared in single toned milk, double toned milk, full fat milk, full fat milk with ghee and in an aqueous suspension...
March 20, 2017: Current Drug Delivery
https://www.readbyqxmd.com/read/28322164/solubilization-and-enhancement-of-ex-vivo-vaginal-delivery-of-progesterone-using-solid-dispersions-inclusion-complexes-and-micellar-solubilization
#12
Abeer S Hassan, Ghareb M Soliman, Mona M El-Mahdy, Gamal El-Din A El-Gindy
Progesterone (PG), a natural female sex hormone is used clinically in menopausal hormone replacement therapy and to control reproductive functions. Its very limited aqueous solubility of 7 µg/ml results in reduced oral bioavailability and low patient compliance when administered in high doses. The aim of this study was to enhance PG aqueous solubility and vaginal delivery using solid dispersion, inclusion complex and micellar solubilization techniques. PG solid dispersions and inclusion complexes were prepared by solvent evaporation method using different polymers, such as cyclodextrins, polyvinyl pyrrolidone (PVP), poly (ethylene glycol) 6000, Pluronic® F-127 and Pluronic® F-68...
March 20, 2017: Current Drug Delivery
https://www.readbyqxmd.com/read/28322163/geriatric-oriented-high-dose-nutraceutical-odts-formulation-and-physicomechanical-characterization
#13
Ahmed M Agiba, Sameh Abdel-Hamid, Maha Nasr, Ahmed S Geneidi
CONTEXT: Oral disintegrating tablets (ODTs) represent a better option than conventional tablets for geriatric population, owing to their fast onset of action and their better patient compliance. OBJECTIVE: Two principal therapeutic high-dose nutraceuticals; chondroitin sulphate and glucosamine were formulated into an oral disintegration tablet (ODT) intended for sublingual administration, and optimized to improve compliance and achieve rapid onset of action in osteoarthritis treatment...
March 20, 2017: Current Drug Delivery
https://www.readbyqxmd.com/read/28322162/arginine-complexes-with-simvastatin-apparent-solubility-in-vitro-dissolution-and-solid-state-characterization
#14
Mmr Meor Mohd Affandi, Minaketan Tripathy, Aba Majeed
Categorized as a Biopharmaceutics Classification System (BCS) Class II drugs, statin exhibit low aqueous solubility and bioavailability thus presenting an obstacle and great challenge to formulation researchers. This paper describes a de novo approach to enhance the aqueous solubility of one of the most commonly prescribed statins i.e. simvastatin (SMV) by forming a complex (SMV-ARG) with cosolute arginine (ARG). The complex has been characterized for its apparent solubility and in vitro dissolution. The solid state characterization has been carried out using Fourier Transform Infra-Red (FTIR) Spectroscopy, Elemental Analysis, X-Ray Powder Diffraction (XRD), Differential Scanning Calorimetry (DSC) analysis, Thermal Gravimetric Analysis (TGA) and Scanning Electron Microscopy (SEM)...
March 20, 2017: Current Drug Delivery
https://www.readbyqxmd.com/read/28302030/gold-nanoparticles-conjugated-levofloxacin-for-improved-antibacterial-activity-over-levofloxacin-alone
#15
Paramdeep Bagga, H H Siddiqui, Juber Akhtar, Tariq Mahmood, Manaal Zahera, Mohd Sajid Khan
Levofloxacin is a potent antibiotic with severe side effects due to its high doses. Bacterial resistance may be due to frequent use of antibiotics. Biogenic gold nanoparticles conjugated levofloxacin (Au-HSA-LvN-NPs) were developed by Human Serum Albumin (HSA) and sulfite reductase-mediated pathways. Au-HSA-LvN-NPs (size = 27.2 ± 1 nm) were readily generated with high emulsion stability zeta potential (̵13.3 mV). The developed nanoparticles were also characterized by UV-visible spectroscopy, Transmission Electron Microscopy and Dynamic Light Scattering techniques...
March 16, 2017: Current Drug Delivery
https://www.readbyqxmd.com/read/28486914/book-review-drug-delivery-to-the-brain-physiological-concepts-methodologies-and-approaches
#16
Maha Nasr
No abstract text is available yet for this article.
March 14, 2017: Current Drug Delivery
https://www.readbyqxmd.com/read/28290242/variation-in-impact-of-use-of-different-propellants-and-excipients-in-pharmaceutical-topical-aerosol-then-and-now
#17
Maunab Patra, Meenakshi Patnaik
Skin is the most suitable and recommendable organ of the human body for topical administration of drugs. Drug delivery system is the methodology used to ensure that the drugs entering in to the body through any route into the body, reach its target for pharmacological action. Patients tend to prefer the painless route of drug administration. So, pharmaceutical aerosols were invented meet patient compliance. Many variations in excipients with respect to compatibility to drugs, stability and economy have been used since start to improve the aerosol system of drug delivery...
March 8, 2017: Current Drug Delivery
https://www.readbyqxmd.com/read/28260506/ph-dependent-behavior-of-novel-gellan-beads-loaded-with-naproxen
#18
Tomasz Osmałek, Anna Froelich, Bartłomiej Milanowski, Magdalena Białas, Kinga Hyla, Mirosław Szybowicz
We have designed, formulated and characterized low-acyl gellan gum (GG) macrobeads to be applied as potential carriers for the delivery of naproxen (NPX) to the distal parts of the gastrointestinal tract. The beads were obtained by ionotropic gelation technique. CaCl2 solution (1%, 9.0×10-2 M) was used as a cross-linking medium. Nine different polymer, drug and surfactant (Tween®80) mixtures were used for beads production. The surface and morphology of the dried beads were analyzed by SEM. Raman spectra of NPX powder and the beads confirmed that NPX did not undergo structural changes during production process...
March 3, 2017: Current Drug Delivery
https://www.readbyqxmd.com/read/28240178/efficient-colonic-delivery-of-dsirna-by-pectin-coated-polyelectrolyte-complex-nanoparticles-preparation-characterization-and-improved-gastric-survivability
#19
Zahid Hussain, Haliza Katas, Set Li Yan, Diyanadalila Jamaludin
BACKGROUND: Despite having excellent anticancer efficacy and ability to knockdown gene expression, the therapeutic feasibility of Dicer-substrate small interference RNA (DsiRNA) is limited due to its poor cellular uptake, chemical instability and rapid degradation in biological environments. OBJECTIVE: The present study was aimed to circumvent the pharmaceutical issues related to DsiRNA delivery to colon for the treatment of colorectal cancer. METHOD: In this study, we have prepared water-soluble chitosan (WSC)-DsiRNA complex nanoparticles (NPs) by a simple complexation method and subsequently coated with pectin to protect DsiRNA from gastric milieu...
February 24, 2017: Current Drug Delivery
https://www.readbyqxmd.com/read/28240177/formulation-of-niosomal-gel-for-enhanced-transdermal-lornoxicam-delivery-in-vitro-and-in-vivo-evaluation
#20
Mohamed Shafik El-Ridy, Soad Aly Yehia, Amira Mohamed Mohsen, Sally A El-Awdan, Asmaa Badawy Darwish
The objective of this study was to investigate the potential of niosomal gels as a transdermal delivery system to improve the permeation and anti-inflammatory activity of Lornoxicam (LX). LX niosomes were prepared by thin film hydration technique and were characterized using Transmission Electron Microscopy (TEM), Differential Scanning Calorimetry (DSC), Particle Size analysis and Zeta potential determination. LX niosomal gel/ LX loaded gel were prepared using Carbopol 934 (2%) and were evaluated for their physical appearance, pH and rheological behaviour...
February 24, 2017: Current Drug Delivery
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