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Current Drug Delivery

Bibo Li, Biqiang Li, Daiying He, Changyan Feng, Zhibin Luo, Mei He
BACKGROUND: The use of misonidazole (MISO), the first and a potential hypoxic tumor cell radiosensitizer, has been limited by peripheral neurotoxicity, thus discouraging phase III clinical trials. OBJECTIVE: To develop a targeted drug delivery and tracing system with pH-sensitive liposomes (SpHLs) and superparamagnetic iron oxide nanoparticles (SPIONs) to counter MISO-related adverse effects and to enable tracing under magnetic resonance. METHODS: SPION-MISO-SpHLs were prepared by a reverse evaporation and freeze-thawing method...
November 14, 2018: Current Drug Delivery
Aum Solanki, Rudy Smalling, Abraham H Parola, Ilana Nathan, Roni Kasher, Yashwant Pathak, Vijaykumar Sutariya
BACKGROUND: Humanin is a novel neuronal peptide that has displayed potential in the treatment of Alzheimer's Disease through the suppression of inflammatory IL-6 cytokine receptors. Such receptors are found throughout the body, including the eye, suggesting its other potential applications. Age-related macular degeneration (AMD) is the leading cause of blindness in the developing world. There is no cure for this disease, and currents treatments have several negative side effects associated with them, making finding other treatment options desirable...
October 31, 2018: Current Drug Delivery
Kumud Joshi, Bhaskar Mazumder, Pronobesh Chattopadhyay, Nilutpal Sharma Bora, Danswrang Goyary, Sanjeev Karmakar
Graphene in nano form has proved to be one of the most remarkable materials. It has a single atom thick molecular structure and it possesses exceptional physical strength, electrical and electronic properties. Applications of the Graphene family of nanomaterials(GFNs) in different fields of therapy have emerged, including for targeted drug delivery in cancer, gene delivery, antimicrobial therapy, tissue engineering and more recently in more diseases including HIV. This review seeks to analyze current advances of potential applications of graphene and its family of nano-materials for drug delivery and other major biomedical purposes...
October 31, 2018: Current Drug Delivery
Kaleem Ullah, Muhammad Sohail, Abdul Mannan, Haroon Rashid, Aamna Shah, Ghulam Murtaza, Shujaat Ali Khan
OBJECTIVE: The study describes the development of chitosan-based (AMPS-co-AA) semi-IPN hydrogels using free radical polymerization technique. METHODS: The resulting hydrogels were characterized using Fourier transform infrared spectroscopy (FTIR), thermogravimetric analysis (TGA), differential scanning calorimetry (DSC), X-Ray diffraction (XRD), and scanning electron microscopy (SEM). The successful crosslinking of chitosan, 2-acrylamido-2-methylpropane sulfonic acid (AMPS), and acrylic acid (AA) was confirmed by FT IR...
October 24, 2018: Current Drug Delivery
Laura A Junqueira, Hudson Polonini, Sharlene Loures, Nadia R B Raposo, Anderson O Ferreira, Marcos Antonio F Brandaob
BACKGROUND: Transdermal delivery is an alternative route for the administration of drugs. However, it requires the development of vehicles that allow the drugs to cross the layers of the skin and reach the systemic circulation. OBJECTIVE: In this study, a new transdermal vehicle was evaluated using progesterone, estradiol, estradiol + estriol (Biest) and ketoprofen administered as model drugs. METHODS: To evaluate the ex vivo permeation of the drugs, the Franz vertical diffusion cell with human skin was used...
October 24, 2018: Current Drug Delivery
U Sambamoorthy, M P Venkataraju, A S Manjappa, M E Bhanoji Rao
BACKGROUND: Gemcitabine (GEM) is found effective in the treatment of many solid tumors. However, its use is restricted due to its small circulation half-life, fast metabolism and low capacity for selective tumor uptake. Folate receptors (FRs) have been recognized as cellular surface markers, which can be used for cancer targeting. PEGylated liposomes decorated with folic acid have been investigated for several anticancer agents not only to extend plasma half-life but also for tumor targeting via folic acid receptors which over expressed on tumor cell surface...
October 24, 2018: Current Drug Delivery
Sarah Zellnitz, Eva Roblegg, Joana Pinto, Eleonore Frohlich
Dry powder inhalers are medical devices used to deliver powder formulations of active pharmaceutical ingredients via oral inhalation to the lungs. Drug particles, from a biological perspective, should reach the targeted site, dissolve and permeate through the epithelial cell layer in order to deliver a therapeutic effect. However, drug particle attributes that lead to a biological activity are not always consistent with the technical requirements necessary for formulation design. For example, small cohesive drug particles may interact with neighbouring particles, resulting in large aggregates or even agglomerates that show poor flowability, solubility and permeability...
October 24, 2018: Current Drug Delivery
Guanbao Li, Pinquan Li, Qiuan Chen, Hnin Ei Thu, Zahid Hussain
BACKGROUND: Owing to their great promise in the spinal surgeries, bone graft substitutes have been widely investigated for their safety and clinical potential. By the current advances in the spinal surgery, an understanding of the precise biological mechanism of each bone graft substitute is mandatory for upholding the induction of solid spinal fusion. OBJECTIVE: The aim of the present review is to critically discuss various surgical implications and level of evidence of most commonly employed bone graft substitutes for spinal fusion...
October 24, 2018: Current Drug Delivery
Kathleen Halasz, Shannon J Kelly, M Tajwar Iqbal, Yashwant Pathak, Vijaykumar Sutariya
The current treatment of ocular neovascularization requires frequent intravitreal injections of anti- vascular endothelial growth factor (VEGF) agents that cause severe side effects. The purpose of this study is to prepare and characterize a novel nanoscale delivery system of apatinib for ocular neovascularization. The optimized formulation showed a particle size of 135.04 nm, polydispersity index (PDI) of 0.28 ± 0.07, encapsulation efficiency (EE) of 65.92%, zeta potential (ZP) of -23.70 ± 8.69 mV, and pH of 6...
October 16, 2018: Current Drug Delivery
Mengyu He, Jiali Zhu, Na Yu, Hui Kong, Xiaoning Zeng, Weiping Xie, Huae Xu
OBJECTIVES: Paclitaxel (Ptx) has been regarded as one of the most effective chemotherapeutic drugs for lung cancers. Increasing studies focused on the nano-delivery system of Ptx due to its poor solubility and hypersensitivity. The aim of the resent study was to investigate the antitumor effects of self-assembled Ptx nano-filaments for lung cancer cells. METHODS: In the present study, we designed and synthesized novel Ptx-loaded nano-filaments through conjugation of Ptx and succinic acid (SA) (Ptx-SA, P-NFs)...
October 16, 2018: Current Drug Delivery
Dong Huang, Deyao Zhao, Jinhui Li, Yuting Wu, Lili Du, Xin-Hua Xia, Xiaoqiong Li, Yulin Deng, Zhihong Li, Yuanyu Huang
Delivery of foreign cargoes into cells is of great value for bioengineering research and therapeutic applications. In this study, we proposed and established a carrier-free gene delivery platform utilizing staggered herringbone channel and silicon nanoneedle array, to achieve high-throughput in vitro gene transfection. With this microchip, fluidic microvortices could be induced by the staggered-herringbone-shaped grooves within the channel, which increased the contact frequency of the cells with the channel substrate...
October 16, 2018: Current Drug Delivery
Mohsin Qureshi, Mohd Aqil, Syed Sarim Imam, Abdul Ahad, Yasmin Sultana
The present work was designed to explore the efficacy of neuroactive drug (risperidone) loaded chitosan lipid nano particle (RIS-CH-LNPs) to enhance the bioactivity in schizophrenia via nasal route. The three-factor and three-level formulation by design approach was used for optimization and their effects were observed on (Y1) size in nm, (Y2) % drug loading, and (Y3) % drug release. The optimized formulation RIS-CH-LNPopt was further evaluated for its surface morphology, ex-vivo permeation study, in-vivo behavior study, and stability study...
October 11, 2018: Current Drug Delivery
Vieri Piazzini, Lorenzo Cinci, Mario D'Ambrosio, Cristina Luceri, Anna Rita Bilia, Maria Camilla Bergonzi
BACKGROUND: Silybin (Sb) is the major flavolignan of the extract of Silybum marianum. It is used for treatment of various acute and chronic liver toxicities, inflammation, fibrosis and oxidative stress. Many studies indicate that Sb is also active against different carcinomas and it has been very recently proposed to be beneficial in type 2 diabetes patients. However, Sb is a low water soluble and low permeable compound. OBJECTIVE: In this study, solid lipid nanoparticles (SLNs) were proposed to enhance the solubility and the intestinal absorption of Sb...
October 8, 2018: Current Drug Delivery
Sunena Jha, Shailendra Kumar Singh, Dina Nath Mishra
BACKGROUND: Presence of blood brain barrier is one of the major hurdle in drug delivery to brain for the treatment of neurological diseases. Alternative and more effective drug delivery approaches have been investigated for the drug targeting to brain in therapeutic range. OBJECTIVE: The present investigation was carried out to improve the galantamine bioavailability in brain by intranasal drug delivery through thiolated chitosan nanoparticles and compared to nasal and oral delivery of its solution using pharmacodynamic activity as well as biochemical estimation...
October 3, 2018: Current Drug Delivery
Ruby Christian, Vaishali Thakkar, Tushar Patel, Mukesh Gohel, Lalji Baldaniya, Purvi Shah, Tosha Pandya, Tejal Gandhi
OBJECTIVE: The focus of this study was to develop in situ injectable implants of Lornoxicam which could provide sustained drug release. METHODS: Biodegradable in situ injectable implants were prepared by polymer precipitation method using polylactide-co-glycolide (PLGA). An optimized formulation was obtained on the basis of drug entrapment efficiency, gelling behavior and in vitro drug release. The compatibility of the formulation ingredients were tested by Fourier transform infrared (FT-IR) spectroscopy, differential scanning colorimetry (DSC)...
September 27, 2018: Current Drug Delivery
Shakiba Naeimi, Hossein Faghihian
In this research, MIL-53(Fe) was magnetized and the performance of the magnetized material as a drug delivery system for doxycycline was studied. The experiments were designed to load the magnetic delivery compounds with different amount of the drug. The In vitro release rate of doxycycline from magnetic MIL-53(Fe) with different drug content into saline buffered fluid (SBF, pH=7.4) and phosphate buffered saline (PBS, pH=3) was then studied. The results showed that the releasing process of the drug in PBS media achieve to the equilibration within 48h with 98% of releasing efficiency, while the releasing process in SBF media (pH=7...
September 26, 2018: Current Drug Delivery
Harjeet Kaur, Baldeep Kumar, Amitava Chakrabarti, Bikash Medhi, Manish Modi, B D Radotra, Ritu Aggarwal, V R Sinha
BACKGROUND: Blood brain permeability is the primary concern when dealing with bio-distribution of drugs to brain in neurological diseases. OBJECTIVE: The purpose of the study is to develop the nanoformulation of Epigallocatechin gallate (EGCG) in order to improve its bioavailability and penetration into brain. METHODS: EGCG loaded solid lipid nanoparticles (SLNs) have been developed using microemulsification method and pharmacological assessments were performed...
September 26, 2018: Current Drug Delivery
Sang Hoon Lee, Yeo-Song Lee, Jae Geun Song, Hyo-Kyung Han
BACKGROUND: Chrysin is a strong inhibitor of breast cancer resistance protein (BCRP) but it is practically insoluble in water. Effective solubilization of chrysin is critical for its pharmaceutical application as an absorption enhancer via inhibition of BCRP-mediated drug efflux. OBJECTIVE: This study aimed to develop an effective oral formulation of chrysin to improve its in vivo effect as an absorption enhancer. METHOD: Solid dispersions (SDs) of chrysin were prepared with hydrophilic carriers having surface acting properties and a pH modulator...
September 24, 2018: Current Drug Delivery
Tapan Kumar Giri
Currently the most important cause of death is cancer. To treat the cancer there are a number of drugs existing in the market but no drug is found to be completely safe and effective. The toxicity of the drugs is the key problem in the cancer chemotherapy. However, plants and plant derived bioactive molecule have proved safe and effective in the treatment of cancers. Phytochemicals that are found in fruits, vegetables, herbs, and plant extract have been usually used for treating cancer. It has been established that several herbal drug have a strong anticancer activity...
September 18, 2018: Current Drug Delivery
Srijita Chakrabarti, Pronobesh Chattopadhyay, Johirul Islam, Subhabrata Ray, Pakalapati Srinivas Raju, Bhaskar Mazumder
Wound infections impose a remarkable clinical challenge that has a considerable influence on morbidity and mortality of patients, resulting in huge impact on economy. The unprecedented advancements in molecular biology have come up with new molecular and cellular targets that can be successfully applied to develop smarter therapeutics against diversified categories of wounds. In the recent years, nanotechnology has achieved a new horizon in the arena of wound care due to its ability to deliver plethora of therapeutics into the target site...
September 18, 2018: Current Drug Delivery
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