journal
MENU ▼
Read by QxMD icon Read
search

Current Alzheimer Research

journal
https://www.readbyqxmd.com/read/28745227/frontotemporal-lobar-degeneration-review-and-update-for-clinical-neurologists
#1
Isabel Hernández, Maria-Victoria Fernández, Lluis Tàrraga, Mercè Boada, Agustín Ruiz
BACKGROUND: Frontotemporal Dementia (FTD) is a heterogeneous group of disorders and the second most frequent cause of early onset dementia making it the highest number of inherited cases. METHODS: FTL is characterized by considerable variability in clinical, genetic and histopathologic features. Patients may present symptoms ranging from behavioural disturbances to different language disorders, with or without motor neuron disorders or associated parkinsonism. Atrophy in frontal and temporal lobes is the most relevant radiological finding...
July 25, 2017: Current Alzheimer Research
https://www.readbyqxmd.com/read/28745226/spatiotemporal-gait-characteristics-associated-with-cognitive-impairment-a-multicenter-cross-sectional-study-the-intercontinental-gait-cognition-decline-initiative
#2
Olivier Beauchet, Helena M Blumen, Michele L Callisaya, Anne-Marie De Cock, Reto W Kressig, Velandai Srikanth, Jean-Paul Steinmetz, Joe Verghese, Gilles Allali
BACKGROUND: The study aims to determine the spatiotemporal gait parameters and/or their combination(s) that best differentiate between cognitively healthy individuals (CHI), patients with mild cognitive impairment (MCI) and those with mild and moderate dementia, regardless of the etiology of cognitive impairment. METHODS: A total of 2099 participants (1015 CHI, 478 patients with MCI, 301 patients with mild dementia and 275 with moderate dementia) were selected from the intercontinental "Gait, cOgnitiOn & Decline" (GOOD) initiative, which merged different databases from seven cross-sectional studies...
July 25, 2017: Current Alzheimer Research
https://www.readbyqxmd.com/read/28730955/itraq-based-proteomic-analysis-of-appsw-ind-mice-provides-insights-into-the-early-changes-in-alzheimer-s-disease
#3
Nan Li, Pinghong Hu, Tiantian Xu, Huan Chen, Xiaoying Chen, Jianwen Hu, Xifei Yang, Lei Shi, Jian-Hong Luo, Junyu Xu
BACKGROUND: Several proteins have been identified as potential diagnostic biomarkers in imaging, genetic, or proteomic studies in Alzheimer disease (AD) patients and mouse models. However, biomarkers for presymptom diagnosis of AD are still under investigation, as are the presymptom molecular changes in AD pathogenesis. OBJECTIVE: In this study, we aim to analyzed the early proteomic changes in APPSw,Ind mice and to conduct further functional studies on interesting proteins...
July 19, 2017: Current Alzheimer Research
https://www.readbyqxmd.com/read/28714391/dancing-as-an-intervention-tool-for-people-with-dementia-a-mini-review-dancing-and-dementia
#4
Blanka Klimova, Martin Valis, Kamil Kuca
BACKGROUND: Research studies show a positive impact of physical activities such as dancing on the improvement of cognitive reserves of people with dementia. OBJECTIVE: The purpose of this study is to explore dancing efficacy on people with dementia and list the key benefits and limitations of dancing therapy for these people. METHODS: The methods used in this study include a method of literature review of available English-written sources with respect to the dancing therapy and dementia in the acknowledged databases PubMed, Web of Science, Springer, and Scopus, and a method of comparison and evaluation of their findings...
July 13, 2017: Current Alzheimer Research
https://www.readbyqxmd.com/read/28714390/cdk5-and-mapt-gene-expression-in-alzheimer-s-disease-brain-samples
#5
Josianne Thomazini Fukasawa, Roger Willian de Labio, Lucas Trevizani Rasmussen, Lucieni Conterno de Oliveira, Elizabeth Chen, João Villares, Gustavo Tureck, Marília de Arruda Cardoso Smith, Spencer Luiz Marques Payão
BACKGROUND: Alzheimer's disease (AD) is a neurodegenerative disorder characterized by extracellular amyloid plaque and neurofibrillary tangles in the brain. Studies have shown that neurons are able to re-enter the cell cycle, but not enough to enable full replication. This leads to cell death and consequent neurodegeneration. OBJECTIVE: This study aimed to characterize the expression of the MAPT gene and CDK5 (the gene involved in cell cycle regulation) in brain samples from patients with AD and controls...
July 13, 2017: Current Alzheimer Research
https://www.readbyqxmd.com/read/28714389/a-peptide-based-pro-drug-ameliorates-amyloid-%C3%AE-induced-neuronal-apoptosis-in-in-vitro-sh-sy5y-cells
#6
Sourav Kumar, Ashim Paul, Sourav Kalita, Awanish Kumar, Saurabh Srivastav, Somoday Hazra, Anup Kumar Ghosh, Bhubaneswar Mandal, Amal Chandra Mondal
BACKGROUND: Alzheimer's disease (AD), a common protein misfolding neurodegenerative disorder, is one of the most common forms of dementia. Amyloid precursor protein (APP) derived amyloid-β (Aβ) proteins accumulated into interneuronal spaces and plays a crucial role in the disease progression and its pathology. The aggregated Aβ exerts its neurotoxic effects by inducing apoptosis and oxidative damage in neuronal cells. OBJECTIVES: We have investigated the effects of a synthesized Pro-Drug peptide (PDp) on Aβ1-40 induced cytotoxicity in human neuroblastoma SH-SY5Y cells, represents one of the most effective strategies in combating human AD...
July 13, 2017: Current Alzheimer Research
https://www.readbyqxmd.com/read/28720071/developmental-expression-and-dysregulation-of-mir-146a-and-mir-155-in-down-s-syndrome-and-mouse-models-of-down-s-syndrome-and-alzheimer-s-disease
#7
A Arena, A M Iyer, I Milenkovic, G G Kovács, I Ferrer, M Perluigi, E Aronica
miR-146a and miR-155 are key regulators of the innate immune response. We hypothesized that an inflammation-mediated dysregulation of these miRNAs may occur in patients with Down syndrome (DS) and Alzheimer's disease (AD). The miRNA expression patterns were investigated by in situ hybridization in developing hippocampus from controls, patients with DS and in adults with AD pathology (DS and sporadic AD; sAD). quantitative real-time PCR was employed to evaluate the miRNA levels in the hippocampus of sAD and in mouse models of DS and AD...
July 6, 2017: Current Alzheimer Research
https://www.readbyqxmd.com/read/28675996/ongoing-electroencephalographic-activity-associated-with-cortical-arousal-in-transgenic-pdapp-mice-happ-v717f
#8
Claudio Del Percio, Wilhelmus Drinkenburg, Susanna Lopez, Cristina Limatola, Jesper F Bastlund, Ditte Zerlang Christensen, Jan T Pedersen, Gianluigi Forloni, Angelisa Frasca, Francesco M Noè, Marina Bentivoglio, Paolo F Fabene, Giuseppe Bertini, Valeria Colavito, Sophie Dix, Raffaele Ferri, Regis Bordet, Jill C Richardso, Claudio Babiloni
BACKGROUND: It has been shown that theta (6-10 Hz) and delta (1-6 Hz) ongoing electroencephalographic (EEG) rhythms revealed variations in the cortical arousal in C57 Wild Type (WT) mice during cage exploration (active condition) compared to awake quiet behavior (passive condition; IMI PharmaCog project, www.pharmacog.eu). OBJECTIVE: Test if these EEG rhythms might be abnormal in old PDAPP mice modeling Alzheimer's disease (AD) with a hAPP Indiana V717F mutation (They show abnormal neural transmission, cognitive deficits, and brain accumulation of Aβ1-42)...
July 4, 2017: Current Alzheimer Research
https://www.readbyqxmd.com/read/28669331/patients-with-increased-non-ceruloplasmin-copper-appear-a-distinct-sub-group-of-alzheimer-s-disease-a-neuroimaging-study
#9
Rosanna Squitt, Ilaria Simonelli, Emanuele Cassetta, Domenico Lupoi, Mauro Rongioletti, Mariacarla Ventriglia, Mariacristina Siotto
BACKGROUND: Meta-analyses show that copper non-bound to ceruloplasmin (non-Cp Cu, also known as 'free' copper) in serum is higher in a percentage of Alzheimer's disease (AD) patients. Genetic heterogeneity in AD patients stratified on the basis of non-Cp Cu cut-off sustains the existence of a copper AD metabolic subtype. OBJECTIVE: In order to find evidence of the existence of a detectable metabolic subtype of AD associated to copper abnormalities, we explore the hypothesis of a neuroimaging pattern heterogeneity in an homogenous and well characterized AD population classified in two groups by the stratification of patients on the basis non-Cp Cu cut-off...
June 23, 2017: Current Alzheimer Research
https://www.readbyqxmd.com/read/28637402/antioxidant-skq1-alleviates-signs-of-alzheimer-s-disease-like-pathology-in-old-oxys-rats-by-reversing-mitochondrial-deterioration
#10
Nataliya G Kolosova, Mikhail A Tyumentsev, Natalia A Muraleva, Elena Kiseleva, Anton O Vitovtov, Natalia A Stefanova
BACKGROUND: Mitochondrial dysfunction is called the missing link between brain aging and Alzheimer's disease (AD), the most common type of age-related dementia worldwide. Among the most advanced and promising of approaches to prevention or slowing of AD are therapeutic strategies targeting mitochondria. OBJECTIVE: Mitochondria-targeted antioxidant SkQ1 can suppress the development of AD signs, but its therapeutic potential in AD at clinical stages is currently unknown...
June 21, 2017: Current Alzheimer Research
https://www.readbyqxmd.com/read/28689494/editorial-circadian-rhythms-are-everywhere-except-in-neurodegenerative-disorders
#11
Dieter Kunz
No abstract text is available yet for this article.
June 16, 2017: Current Alzheimer Research
https://www.readbyqxmd.com/read/28641509/brain-information-sharing-during-visual-short-term-memory-binding-yields-a-memory-biomarker-for-familial-alzheimer-s-disease
#12
Mario A Parra, Ezequiel Mikulan, Natalia Trujillo, Sergio Della Sala, Francisco Lopera, Facundo Manes, John Starr, Agustin Ibanez
BACKGROUND: Alzheimer's disease (AD) as a disconnection syndrome disrupts both brain information sharing and memory binding functions. The extent to which these two phenotypic expressions are shared pathophysiological mechanisms remains unknown. OBJECTIVE: To unveil the electrophysiological correlates of integrative memory impairments in AD towards new memory biomarkers for its prodromal stages. METHODS: Patients with 100% risk of familial AD (FAD) and healthy controls underwent assessment with the VSTM binding test (VSTMBT) while we recorded their EEG...
June 14, 2017: Current Alzheimer Research
https://www.readbyqxmd.com/read/28595523/blue-enriched-lighting-for-older-people-living-in-care-homes-effect-on-activity-actigraphic-sleep-mood-and-alertness
#13
Samantha Hopkins, Peter Lloyd Morgan, Luc J M Schlangen, Peter Williams, Debra J Skene, Benita Middleton
Environmental (little outdoor light; low indoor lighting) and age-related physiological factors (reduced light transmission through the ocular lens, reduced mobility) contribute to a light-deprived environment for older people living in care homes. This study investigates the effect of increasing indoor light levels with blue-enriched white lighting on objective (rest-activity rhythms, performance) and self-reported (mood, sleep, alertness) measures in older people. Eighty residents (69 female), aged 86 ± 8 yrs (mean ± SD), participated (MMSE 19 ± 6)...
June 7, 2017: Current Alzheimer Research
https://www.readbyqxmd.com/read/28595522/implementation-of-dynamic-lighting-in-a-nursing-home-impact-on-agitation-but-not-on-rest-activity-patterns
#14
Amely Wahnschaffe, Claudia Nowozin, Sven Haedel, Andreas Rath, Stefan Appelhof, Mirjam Münch, Dieter Kunz
Disturbances of circadian rest-activity rhythms in demented patients often culminate in the clinical problem of evening and nighttime agitation. The aim of the current study was to test the impact of a dynamic lighting system on agitation and rest-activity cycles. From midwinter on, a ceiling mounted dynamic lighting system was installed in the common room of a nursing home and programmed to produce high illuminance with higher blue light proportions during the day and lower illuminance without blue light in the evening...
June 7, 2017: Current Alzheimer Research
https://www.readbyqxmd.com/read/28558638/heart-rate-variability-indexes-in-dementia-a-systematic-review-with-a-quantitative-analysis
#15
Vanessa Pereira da Silva, Bruno Ribeiro Ramalho Oliveira, Roger Gomes Tavares Mello, Helena Moraes, Andrea Camaz Deslandes, Jerson Laks
BACKGROUND: Decreased HRV indexes indicate a low vagal activity and may be associated with development of dementia. The neurodegenerative process is associated with the cardiovascular autonomic control. OBJECTIVE: The aim of this systematic review was to investigate the effect size magnitude of the HRV indexes in the evaluation of autonomic dysfunction in elderly people with dementia. METHODS: PubMed (Medline), Web of Science, Scopus, Scielo, Lilacs, and APA Psycnet were consulted...
May 30, 2017: Current Alzheimer Research
https://www.readbyqxmd.com/read/28558637/the-cognitive-effects-of-wearable-cameras-in-mild-alzheimer-disease-an-experimental-study
#16
Ana Rita Silva, Maria Salomé Pinho, Luís Macedo, Christopher J A Moulin
BACKGROUND: Wearable cameras are a new type of intervention aimed at stimulating memory in Alzheimer's disease (AD). Such passive external memory aids have started to be considered as alternatives to both more active external aids (such as writing in diaries, journals, and timetables) and to internal cognitive strategies (such as spaced retrieval, errorless learning). OBJECTIVE: In order to understand the benefits of these innovative devices for memory compensation, the present experiment examined the effectiveness of two memory training strategies: SenseCam, a wearable camera, a passive external memory aid and a memory training programme (MEMO+) created from tasks known to stimulate memory, in comparison with a control condition, a personal written diary...
May 30, 2017: Current Alzheimer Research
https://www.readbyqxmd.com/read/28558636/%C3%AE-amyloid-upregulates-intracellular-clusterin-but-not-secretory-clusterin-in-primary-cultured-neurons-and-app-mice
#17
Ping Wang, Keliang Chen, Yuehua Gu, Qihao Guo, Zhen Hong, Qianhua Zhao
Backgound: Previous studies have suggested that the expression of Aβ and clusterin is positively correlated. However, the causal relationship between Aβ and clusterin has not been exactly clarified. METHODS: In this study, primary hippocampal neurons were treated with Aβ42; clusterin mRNA and protein expression was assessed. Furthermore, we evaluated Aβ and clusterin protein expression in the brains of APP/PSEN1 mice, as well as serum clusterin concentration. RESULTS: We observed here that the exposure of primary hippocampal neurons to Aβ42 induced an overexpression of intracellular clusterin, but the level of clusterin in supernatants was not changed...
May 30, 2017: Current Alzheimer Research
https://www.readbyqxmd.com/read/28545364/bright-light-delights-effects-of-daily-light-exposure-on-emotions-rest-activity-cycles-sleep-and-melatonin-secretion-in-severely-demented-patients
#18
Mirjam Münch, Michael Schmieder, Katharina Bieler, Rolf Goldbach, Timo Fuhrmann, Naomi Zumstein, Petra Vonmoos, Jean-Louis Scartezzini, Anna Wirz-Justice, Christian Cajochen
We tested whether the effects of a dynamic lighting system are superior to conventional lighting on emotions, agitation behaviour, quality of life, melatonin secretion and circadian rest-activity cycles in severely demented patients. As a comparison, an age matched control patient group was exposed to conventional lighting. For none of the output measures, significant differences between the two lighting conditions were found during the 8 study weeks in fall/winter. Thus, we divided the patient cohort (n = 89) into two groups, solely based on the median of their daily individual light exposure...
May 22, 2017: Current Alzheimer Research
https://www.readbyqxmd.com/read/28545363/sleep-wake-patterns-and-cognition-of-older-adults-with-amnestic-mild-cognitive-impairment-amci-a-comparison-with-cognitively-healthy-adults-and-moderate-alzheimer-s-disease-patients
#19
Emma J Wams, Gordon K Wilcock, Russell G Foster, Katharina Wulff
Age-related cognitive impairment and the prevalence of neurodegenerative disease contribute to decreasing quality of life in affected individuals and their families as well as demand considerable societal responsibility. Sleep supports overall brain activity and contributes to both physical and mental health. As a result sleep is an attractive target for exploring ways to promote health in accelerated cognitive aging. The aims of this study were to characterise cognitive performance and sleep-wake behaviour in older adults with different degrees of cognitive impairment...
May 22, 2017: Current Alzheimer Research
https://www.readbyqxmd.com/read/28545362/insight-into-the-role-of-photoreception-and-light-intervention-for-sleep-and-neuropsychiatric-behaviour-in-the-elderly
#20
Katharina Wulff, Russell G Foster
Light exerts influences on many physiological and behavioural functions in humans. These functions can be described as image-forming (IF) and non-image forming (NIF) visual processes, both originating in the retina of the eye. Image-forming refers to vision; the process of detecting and distinguishing shapes and colour of objects. Non-image forming refers to detecting level of light intensity or brightness of ambient space, which affects basal physiology such as cycles of rest and activity or the endocrine system...
May 22, 2017: Current Alzheimer Research
journal
journal
40646
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"