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Current Alzheimer Research

Ignazio Vecchio, Cristina Tornali, Giulia Malaguarnera, Nicola Luigi Bragazzi, Michele Malaguarnera
The progressive supranuclear palsy is a progressive neurodegenerative disease characterized by Parkinsonism, oculomotor abnormalities, early postural instability and cognitive impairment. Neurodegeneration in PSP is associated with tau protein, but the mechanisms by which tau abnormalities lead to cell dysfunction and death are not well understood. Neuro-behavioural problems related to the fear and loss of autonomy can determinate many bioethical implications. Careful planning involving patients' families, academic and industry researchers were necessary to ensure improvement in quality of life...
May 6, 2018: Current Alzheimer Research
Carina Wattmo, Elisabet Londos, Lennart Minthon
BACKGROUND: A varying response to cholinesterase inhibitor (ChEI) treatment has been reported among patients with Alzheimer's disease (AD). Whether the individual-specific response directly affects time to nursing home placement (NHP) was not investigated. OBJECTIVE: We examined the relationship between the 6-month response to ChEI and institutionalization. METHODS: In a prospective, observational, multicenter study, 881 outpatients with a clinical AD diagnosis and a Mini-Mental State Examination score of 10-26 at the start of ChEI therapy (baseline) were included...
May 6, 2018: Current Alzheimer Research
Sudipta Chakrabarti, Malabendu Jana, Avik Roy, Kalipada Pahan
Neuroinflammation plays an important role in the pathogenesis of various neurodegenerative diseases including Alzheimer's disease (AD). Suppressor of cytokine signaling 3 (SOCS3) is an anti-inflammatory molecule that suppresses cytokine signaling and inflammatory gene expression in different cells including microglia. However, pathways through which SOCS3 could be upregulated are poorly described. Cinnamic acid is a metabolite of cinnamon, a natural compound that is being widely used all over the world as a spice or flavoring agent...
May 6, 2018: Current Alzheimer Research
Yue Ruan, Jun Tang, Xiaofei Guo, Kelei Li, Duo Li
BACKGROUND: Epidemiological studies showed that dietary fat intake was associated with Alzheimer's disease (AD) and dementia risk, however, the association remain inconsistent. This meta-analysis aimed to systematically examine the association of dietary fat intake with AD and dementia risk. METHODS: We have systematically searched PubMed, Embase and the Cochrane Library up to May 1st 2017. Prospective cohort studies were included if they reported on the association of dietary fat intake with AD and dementia risk...
April 27, 2018: Current Alzheimer Research
Petra Maresova, Signe Tomsone, Petre Lameski, Joana Madureira, Ana Mendes, Eftim Zdravevski, Ivan Chorbev, Vladimir Trajkovik, Moriah Ellen, Kasper Rodile
In the nineties, numerous studies began to highlight the problem of the increasing number of people with Alzheimer's disease in developed countries, especially in the context of demographic progress. At the same time, the 21st century is typical of the development of advanced technologies that penetrate all areas of human life. Digital devices, sensors, and intelligent applications are tools that can help seniors and allow better communication and control of their caregivers. The aim of the paper is to provide an up-to-date summary of the use of technological solutions for improving health and safety for people with Alzheimer's disease...
April 27, 2018: Current Alzheimer Research
David A Loewenstein, Rosie E Curiel, Monica Rosselli, Ailyn Penate, Maria T Greig-Custo, Russell M Bauer, Salvador M Guinjoan, Kevin S Hanson, Chunfei Li, Gabriel Lizarraga, William W Barker, Valeria Torres, Steven DeKosky, Malek Adjouadi, Ranjan Duara
BACKGROUND: Accumulating evidence indicates that the failure to recover from the effects of proactive semantic interference [frPSI] represents an early cognitive manifestation of preclinical Alzheimer's disease. A limitation of this novel paradigm has been a singular focus on the number of targets correctly recalled, without examining co-occurring semantic intrusions [SI] that may highlight specific breakdowns in memory. OBJECTIVES: We focused on SI and their relationship to amyloid load and regional cortical thickness among persons with amnestic mild cognitive impairment...
April 27, 2018: Current Alzheimer Research
Giulia Mazzon, Federica De Dea, Tatiana Cattaruzza, Paolo Manganotti, Fabrizio Monti, Agostino Accardo
BACKGROUND: Mild (MCI) and Subjective Cognitive Impairment (SCI) are conditions at risk of developing Alzheimer's disease (AD). Differential between normal aging at early stages can be really challenging; available biomarkers need to be combined and can be quite invasive and expensive. OBJECTIVE: The aim of this pilot study is to examine possible EEG alterations in MCI and SCI compared to controls, analyzing if a cognitive task could highlight early AD hallmarks...
April 26, 2018: Current Alzheimer Research
M A Pappolla, E Matsubara, R Vidal, J Pacheco-Quinto, B Poeggeler, M Zagorski, K Sambamurti
BACKGROUND: It has been postulated that inadequate clearance of the amyloid β protein (Aβ) plays an important role in sporadic Alzheimer's disease (AD). While the blood brain barrier has taken the center stage in processes involving Aβ clearance, little information is available about the role of the lymphatic system. OBJECTIVE: To confirm and expand our initial finding that Aβ is cleared through the lymphatic system. Lymphatic clearance of metabolic "waste" products from the brain into the peripheral lymphatic system has been known for many years...
April 10, 2018: Current Alzheimer Research
Ryan Van Patten, Anne M Fagan, David A S Kaufman
BACKGROUND: There exists a need for more sensitive measures, capable of detecting subtle cognitive decline due to Alzheimer's disease. OBJECTIVE: To advance the literature in Alzheimer's disease by demonstrating that performance on a cued-Stroop task is impacted by preclinical Alzheimer's disease neuropathology. METHOD: Twenty-nine cognitively asymptomatic older adults completed a computerized, cued-Stroop task in which accuracy rates and intraindividual variability in reaction times were the outcomes of interest...
April 4, 2018: Current Alzheimer Research
Elizabeta B Mukaetova-Ladinska, Zeinab Abdell-All, Joana Andrade, Joaquim Alves da Silva, Irina Boksha, Gulnur Burbaeva, Raj N Kalaria, John T O'Brien
BACKGROUND: Cerebrospinal fluid (CSF) measures of tau and amyloid proteins have now been largely accepted to be a diagnostic tool to aid the clinical diagnosis of Alzheimer's disease (AD), but CSF is not routinely obtained in most clinical settings. There is a need, therefore, to uncover additional readily accessible peripheral biomarkers that will enable comprehensive detection of AD-specific proteins in blood and blood derivates. OBJECTIVES: Blood platelets contain proteins found in neuronal cell lines, including tau protein...
April 4, 2018: Current Alzheimer Research
Celine De Looze, Finnian Kelly, Lisa Crosby, Aisling Vourdanou, Robert F Coen, Cathal Walsh, Brian A Lawlor, Richard B Reilly
BACKGROUND: Speech and language impairments, generally attributed to lexico-semantic deficits, have been documented in Mild Cognitive Impairment (MCI) and Alzheimer's disease (AD). This study investigates the temporal organisation of speech (reflective of speech production planning) in reading aloud in relation to cognitive impairment, particularly working memory and attention deficits in MCI and AD. The discriminative ability of temporal features extracted from a newly designed read speech task is also evaluated for the detection of MCI and AD...
April 4, 2018: Current Alzheimer Research
Shu-Ying Liu, Shuai Lu, Xiao-Lin Yu, Shi-Gao Yang, Wen Liu, Xiang-Meng Liu, Shao-Wei Wang, Jie Zhu, Mei Ji, Dong-Qun Liu, Zi-Ping Zhang, Rui-Tian Liu
BACKGROUND: Alzheimer's disease (AD) is a neurodegenerative disease featured by memory loss, neuroinflammation and oxidative stress. Overproduction or insufficient clearance of Aβ leads to the pathological aggregation and deposition, which is considered the predominant neuropathological hallmark of AD. Therefore, reducing Aβ levels and inhibiting Aβ-induced neurotoxicity are feasible therapeutic strategies for AD treatment. Wolfberry has been traditionally used as a natural antioxidant and anti-aging product...
April 4, 2018: Current Alzheimer Research
Fidelia Bature, Dong Pang, Anthea Robinson, Norma Polson, Yannis Pappas, Barbara Guinn
OBJECTIVE: Evidence suggests that individuals with Alzheimer's disease (AD) are often diagnosed in the later stages of their disease with a poor prognosis. This study aimed to identify patterns in signs and symptoms preceding the clinical diagnosis of AD to suggest a predictive model for earlier diagnosis of the disease in the primary care. DESIGN: A retrospective medical record review; nested case control design. PARTICIPANTS: Participants included one hundred and nine patients from three general practice (GP) surgeries in Milton Keynes and Luton Clinical Commissioning groups (CCG) (37 cases with AD and 72 controls without AD)...
April 4, 2018: Current Alzheimer Research
José María Cornejo-Montes-de-Oca, Rebeca Hernández-Soto, Arturo G Isla, C E Morado-Urbina, Fernando Peña-Ortega
Amyloid beta inhibits olfactory bulb function. The mechanisms involved in this effect must include alterations in network excitability, inflammation and the activation of different transduction pathways. Thus, here we tested whether tolfenamic acid, a drug that modulates several of these pathological processes, could prevent amyloid beta-induced olfactory bulb dysfunction. • Objective: To test whether tolfenamic acid prevents amyloid beta-induced alterations in olfactory bulb network function, olfaction and GSK3β activity...
February 22, 2018: Current Alzheimer Research
Shohreh Majd, John H T Power
BACKGROUND: Emerging evidence supports the hypothesis that metabolism dysfunction is involved in pathogenesis of Alzheimer's disease (AD). One aspect of metabolic dysfunction includes dysregulation of adenosine monophosphate kinase protein kinase (AMPK) and mammalian target of rapamycin (mTOR) metabolic axis, which is extensively present in some of the leading causes of AD such as cerebrovascular diseases, type 2 diabetes and brain ischaemic events. While the molecular basis underlying this metabolic dysregulation remains a significant challenge, mitochondrial dysfunction due to aging appears to be an essential factor to activate AMPK/mTOR signaling pathway, leading to abnormal neuronal energy metabolism and AD pathology...
February 22, 2018: Current Alzheimer Research
Yian Gu, Jennifer J Manly, Richard P Mayeux, Adam M Brickman
BACKGROUND: Accumulating evidence suggests that dietary factors are associated with Alzheimer's disease, cognition, and brain health in older adults. It is however unclear whether inflammation explains this association. OBJECTIVE: To examine whether an inflammation-related nutrient pattern (INP) was associated with neuroimaging and cognitive measures of brain health. METHOD: The current cross-sectional study included 330 non-demented elderly (mean age 79 years at MRI scan) participants in a multi-ethnic, community-based cohort study who had information on nutritional intake (estimated from food frequency questionnaire), circulating C-reactive protein and interleukin- 6 (measured by ELISA), MRI scans, and cognition...
March 14, 2018: Current Alzheimer Research
Pasquale Ricci, Francesco Massoni, Lidia Ricci, Emanuela Onofri, Giuseppe Donato, Serafino Ricci
BACKGROUND: Among the myriad of factors modulating quality of life assessments estimated in patients presenting a variety of cognitive impairments, the distinctive and critical influence of diet and exercise cannot be overestimated. OBJECTIVE: The objective of this study was to review the evidence to confirm the association between these health-endowering agents and cognitive performance in People With Dementia as well as providing a correlation between Mini Mental State Examination scores and available anthropometric data...
March 14, 2018: Current Alzheimer Research
Sandra Moreno
No abstract text is available yet for this article.
February 22, 2018: Current Alzheimer Research
Fabricio Ferreira de Oliveira, Elizabeth Suchi Chen, Marilia Cardoso Smith, Paulo Henrique Ferreira Bertolucci
BACKGROUND: While the angiotensin-converting enzyme degrades amyloid-β, angiotensinconverting enzyme inhibitors (ACEis) may slow cognitive decline by way of cholinergic effects, by increasing brain substance P and boosting the activity of neprilysin, and by modulating glucose homeostasis and augmenting the secretion of adipokines to enhance insulin sensitivity in patients with Alzheimer's disease dementia (AD). We aimed to investigate whether ACE gene polymorphisms rs1800764 and rs4291 are associated with cognitive and functional change in patients with AD, while also taking APOE haplotypes and anti-hypertensive treatment with ACEis into account for stratification...
February 22, 2018: Current Alzheimer Research
Cedric Annweiler, Lise Doineau, Lucie Gerigne, Anais Provendier, Spyridon N Karras, Olivier Beauchet, Bruno Fantino, Guillaume T Duval
BACKGROUND: Older adults with hypovitaminosis D report more often subjective cognitive complaints, especially with regards to memory. This raises prospects that vitamin D may improve older adults' subjective experience of memory disorders. OBJECTIVE: To determine among older community-dwellers whether higher serum 25-hydroxyvitamin D (25OHD) concentrations were associated with fewer memory complaints, while considering the different subtypes of memory complaints...
February 1, 2018: Current Alzheimer Research
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