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Current Neurovascular Research

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https://www.readbyqxmd.com/read/30514190/increased-neutrophil-to-lymphocyte-ratios-are-associated-with-greater-risk-of-hemorrhagic-transformation-in-patients-with-acute-ischemic-stroke
#1
Quhong Song, Yisong Li, Yanan Wang, Chenchen Wei, Junfeng Liu, Ming Liu
BACKGROUND AND PURPOSE: Leukocyte is currently known as a potential risk factor for symptomatic intracranial hemorrhage after reperfusion therapy, but there is little evidence on whether leukocyte is associated with the overall risk of hemorrhagic transformation (HT) after acute ischemic stroke (AIS). METHODS: Patients within seven days after stroke onset were included between January 2016 and October 2017. The laboratory data were collected within 24 hours after admission...
December 4, 2018: Current Neurovascular Research
https://www.readbyqxmd.com/read/30514189/combining-diffusion-weighted-imaging-patterns-with-abcd2-score-predicts-stroke-risk-after-transient-ischemic-attack
#2
Lulu Pei, Bo Song, Hui Fang, Yuan Gao, Yinan Guo, Kai Liu, Yapeng Li, Xiao Wang, Xuan Tian, Jun Wu, Shilei Sun, Yuming Xu
BACKGROUND: Recent studies indicated that multiple acute infarctions on diffusion-weighted imaging (DWI) were associated with a higher risk of stroke. OBJECTIVE: The study aims to estimate the association of different infarction patterns and ABCD2 score with the prognosis of transient ischemic attack (TIA). METHOD: We prospectively analyzed the data from TIA database of the First Affiliated Hospital of Zhengzhou University. The predictive outcome was 90-day ischemic stroke...
December 4, 2018: Current Neurovascular Research
https://www.readbyqxmd.com/read/30484407/sirtuins-developing-innovative-treatments-for-aged-related-memory-loss-and-alzheimer-s-disease
#3
Kenneth Maiese
The world's population continues to age at a rapid pace. By the year 2050, individuals over the age of 65 will account for sixteen percent of the world's population and life expectancy will increase well over eighty years of age. Accompanied with the aging of the global population is a significant rise in non-communicable diseases (NCDs). Neurodegenerative disorders will form a significant component for NCDs. Currently, dementia is the 7th leading cause of death and can be the result of multiple causes that include diabetes mellitus, vascular disease, and Alzheimer's disease (AD)...
November 28, 2018: Current Neurovascular Research
https://www.readbyqxmd.com/read/30484406/gender-specific-relationship-between-uric-acid-levels-and-prognosis-after-cerebral-venous-thrombosis
#4
Bo Song, Kai Liu, Yuan Gao, Lu Zhao, Hui Fang, Yunchao Wang, Andrew Wang, Gillian Coates, Shen Li, Yusheng Li, Yuming Xu
BACKGROUND: Uric acid (UA) has been known to play a neuroprotective role in ischemic stroke patients. However, the relationship between UA levels and prognosis in patients with cerebral venous thrombosis (CVT) has not been investigated. METHOD: A total of 228 CVT patients were retrospectively identified and were divided into three groups according to UA levels. Functional outcome was evaluated by modified Rankin Scale (mRS). Multivariate logistic regression analysis was conducted to evaluate the relation between UA levels and functional outcome after CVT...
November 27, 2018: Current Neurovascular Research
https://www.readbyqxmd.com/read/30484405/blood-pressure-and-the-risk-of-dementia-a-dose-response-meta-analysis-of-prospective-studies
#5
Zuo-Teng Wang, Wei Xu, Hui-Fu Wang, Lin Tan, Chen-Chen Tan, Jie-Qiong Li, Jin-Tai Yu, Lan Tan
BACKGROUND: A number of epidemiological studies have revealed a controversial correlation between blood pressure (BP) and the risk of dementia, hindering translation of reseach into preventative practice. OBJECTIVE: To meta-analyze the dose-response relationship of dementia and its subtypes to BP. METHOD: Relevant studies were identified via a systematic retrieval analysis in electronic databases from inception to May 1, 2017. Linear and non-linear dose-response meta-analyses were conducted to evaluate the effects of BP on dementia risk...
November 27, 2018: Current Neurovascular Research
https://www.readbyqxmd.com/read/30484404/9-4t-magnetic-resonance-imaging-of-the-mouse-circle-of-willis-enables-serial-characterization-of-flow-induced-vascular-remodeling-by-computational-fluid-dynamics
#6
Vincent M Tutino, Hamidreza Rajabzadeh-Oghaz, Anusha R Chandra, Liza C Gutierrez, Ferdinand Schweser, Marilena Preda, Aichi Chien, Kunal Vakharia, Ciprian Ionita, Adnan Siddiqui, John Kolega
BACKGROUND: The neurovasculature dynamically responds to changes in cerebral blood flow by vascular remodeling processes. Serial imaging studies in mouse models could help to characterize pathologic and physiologic flow-induced remodeling of the Circle of Willis (CoW). METHOD: We induced flow-driven pathologic cerebral vascular remodeling in the CoW of mice (n=3) by ligation of the left common carotid artery (CCA), and the right external carotid and pterygopalatine arteries, increasing blood flow through the basilar and the right internal carotid arteries...
November 27, 2018: Current Neurovascular Research
https://www.readbyqxmd.com/read/30468129/elevated-serum-human-cytomegalovirus-igm-levels-in-the-acute-phase-of-ischemic-stroke-are-associated-with-increased-risk-of-death-and-major-disability
#7
Chenhuan Zhang, Ping Huang, Peipei Zhang, Mo Zhou, Ya Gao, Yonghong Zhang, Yumei Guo, Liying Lv, Tan Xu
BACKGROUND: There was a lack of studies on the association between human cytomegalovirus (HCMV) infection and prognosis of ischemic stroke, although it was indicated that human cytomegalovirus DNA has played a role in several cardiovascular disorders. OBJECTIVE: To examine the association between HCMV IgM levels in the acute phase and death and major disability after 2 weeks of acute ischemic stroke. METHODS: Serum HCMV IgM levels were measured in 1150 participants in China...
November 23, 2018: Current Neurovascular Research
https://www.readbyqxmd.com/read/30468128/bradykinin-receptors-in-ischemic-injury
#8
Min Tang, Fangping He, Li Ma, Ping Liu, Jianwen Wang, Xiongchao Zhu
Bradykinin(BK) is a major kinin substance in the kallikrein-kinin system (KKS) that acts in conjunction with target cell bradykinin receptors and is involved in a variety of systems and organs. Functional regulation and pathophysiological processes such as cardiovascular, renal, central nervous system regulation, glucose metabolism, cell proliferation, smooth muscle contraction, inflammation, pain, shock, and tissue damage processes, etc. The role and mechanism of receptors in the mediation of ischemic injury in tissues was reviewed...
November 23, 2018: Current Neurovascular Research
https://www.readbyqxmd.com/read/30468126/erk-map-kinase-activation-is-evident-in-activated-microglia-of-the-striatum-and-substantia-nigra-in-an-acute-and-chronically-induced-mouse-model-of-parkinson-s-disease
#9
Sumit Sarkar, Edward Lu, James Raymick, Joseph Hanig, Qiang Gu
BACKGROUND: Parkinson disease (PD) is one of the most debilitating disorder of the elderly where dopaminergic neurons of the midbrain especially in the substantia nigra (SNc) are damaged. Dopaminergic neurons are synthesized in the midbrain project to the striatum (Caudate-putamen-CPU). Few evidence have suggested that the extracellular signal-regulated kinase ½ (ERK ½) in the brain is activated after 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) exposure, to our knowledge no study has yet been done to demonstrate whether such activation occurs in neurons or in glia...
November 23, 2018: Current Neurovascular Research
https://www.readbyqxmd.com/read/30468125/are-cerebral-perfusion-and-atrophy-linked-in-multiple-sclerosis-evidence-for-a-multifactorial-approach-to-assess-neurodegeneration
#10
Maria Marcella Laganà, Laura Mendozzi, Laura Pelizzari, Niels Peter Bergsland, Luigi Pugnetti, Pietro Cecconi, Giuseppe Baselli, Mario Clerici, Raffaello Nemni, Francesca Baglio
Background Grey matter (GM) atrophy has been extensively described in Multiple Sclerosis (MS) patients, while cerebral hypoperfusion has been less consistently reported. Since hypoperfusion might be related to atrophy, we evaluated the presence of both damages. Objective We aimed to assess if the regions of altered perfusion and atrophy overlapped with one another and if the two parameters were locally related. Method 3D-T1 weighted and arterial spin labelling sequences were acquired using a 1.5T Magnetic Resonance Imaging scanner from 26 relapsing remitting MS patients and 26 healthy controls (HC)...
November 23, 2018: Current Neurovascular Research
https://www.readbyqxmd.com/read/30468127/nlrp3-inflammasome-activation-leads-to-epileptic-neuronal-apoptosis
#11
Kai Shen, Quangao Mao, Xiaoqin Yin, Chunyan Zhang, Yi Jin, Aiqing Deng, Zhifeng Gu, Bohua Chen
While the NOD-like receptor protein-3 (NLRP3) inflammasome is involved in a variety of nervous system diseases, its role in epilepsy still needs to be further investigated. </p><p> METHODS: The expressions of NLRP3 inflammasome and apoptosis related proteins were examined by Western blot. MTT was used to assess cell viability. The role of NLRP3 inflammasome in epileptic neuronal apoptosis was further validated in NLRP3 knockout (KO) mice by Nissl staining. </p><p> RESULTS: Exposure of SH-SY5Y cells to free-Mg2+ solutions increased the expression of NLRP3 inflammasome with a concomitant increase in neuronal apoptosis...
November 22, 2018: Current Neurovascular Research
https://www.readbyqxmd.com/read/30466383/a-piece-of-the-rock-a-critical-role-for-rho-kinases-in-the-nervous-system
#12
Kenneth Maiese
No abstract text is available yet for this article.
November 22, 2018: Current Neurovascular Research
https://www.readbyqxmd.com/read/30101705/microrna-490-5p-targets-ccnd1-to-suppress-cellular-proliferation-in-glioma-cells-and-tissue-through-cell-cycle-arrest
#13
Long Zhao, Xiaoping Tang, Renguo Luo, Jie Duan, Yuanchuan Wang, Binbin Yang
BACKGROUND: Glioma is a type of tumor that starts in the glial cells of brain and spine. However, the underlying molecular mechanisms of miRNAs dysregulation in glioma initiation and progression is largely unclear. OBJECTIVE: To further understand the molecular mechanism of miR-490-5P functions and how miR-490 regulated CCND1 function. METHODS: The expression of miR-490-5P in glioma tissues and cells was measured by qRT-PCR and ISH. Cell transfection is responsible for miR-490-5P overexpression and knockdown...
2018: Current Neurovascular Research
https://www.readbyqxmd.com/read/30101704/calcineurin-inhibition-and-protein-kinase-a-activation-limits-cognitive-dysfunction-and-histopathological-damage-in-a-model-of-dementia-of-the-alzheimer-s-type
#14
Amit Kumar, Nirmal Singh
AIM: The aim of the present work was to explore the outcome of combination of Calcineurin (CaN) inhibitor and Protein Kinase A (PKA) activator, in mouse models of experimental dementia. METHODS: Cognitive deficits were induced in mice by injecting Streptozotocin (STZ) intracerebroventricularly (i.c.v.); on the other hand aged animals were procured as a natural model of dementia. To assess cognitive function of mice Morris water maze (MWM) test was utilized; various biochemical studies and histopathological studies were also carried out...
2018: Current Neurovascular Research
https://www.readbyqxmd.com/read/30062967/curcumin-reduces-neuronal-loss-and-inhibits-the-nlrp3-inflammasome-activation-in-an-epileptic-rat-model
#15
Qianchao He, Lingfei Jiang, Shanshan Man, Lin Wu, Yueqiang Hu, Wei Chen
BACKGROUND: Epilepsy is a chronic neurological disorder affecting an estimated 50 million people worldwide. Emerging evidences have accumulated over the past decades supporting the role of inflammation in the pathogenesis of epilepsy. Curcumin is a nature-derived active molecule demonstrating anti-inflammation efficacy. However, its effects on epilepsy and corresponding mechanisms remain elusive. OBJECTIVE: To investigate the effects of curcumin on epilepsy and its underlying mechanism...
2018: Current Neurovascular Research
https://www.readbyqxmd.com/read/30051791/cerebral-inflow-and-outflow-discrepancies-in-severe-sudden-sensorineural-hearing-loss
#16
Andrea Ciorba, Mirko Tessari, Manuela Mazzoli, Valentina Tavoni, Francesco Sisini, Claudia Aimoni, Francesco Stomeo, Erica Menegatti, Stefano Pelucchi, Paolo Zamboni
The aim of this study is to evaluate whether cerebral inflow and outflow abnormalities, assessed by the means of a validated ultrasound model, could be associated with Sudden Sensorineural Hearing Loss (SSNHL). According to Clark, a total of 42 patients affected by severe SSNHL and 19 healthy volunteers matched by gender without any history of sudden hearing impairment have been included in this study. Patients and controls underwent EchocolorDoppler assessment of brain hemodynamics. All subjects affected by SSNHL were also assessed with Auditory Brainstem Responses (ABR) and Magnetic Resonance Imaging (MRI) in order to exclude retrocochlear pathology...
2018: Current Neurovascular Research
https://www.readbyqxmd.com/read/30047329/reduced-hemoglobin-levels-combined-with-an-increased-plasma-concentration-of-vasoconstrictive-endothelin-1-are-strongly-associated-with-poor-outcome-during-acute-ischemic-stroke
#17
Agnieszka Meller, Monika Golab-Janowska, Edyta Paczkowska, Boguslaw Machalinski, Wioletta Pawlukowska, Przemyslaw Nowacki
The association of poor outcome and mortality with low levels of hemoglobin (Hb) and hematocrit (HcT) in patients admitted after acute Ischemic Stroke (IS) was recently demonstrated. The mechanisms behind this still remain unclear. Our study aims to find out whether mRNA expressions and plasma concentrations of endothelin-1 (ET-l), endothelin-2 (ET-2) and endothelin-3 (ET-3) remain different in IS sufferers with low HcT and Hb levels in comparison with those whose HcT i Hb levels during a severe IS episode remain within the norm...
2018: Current Neurovascular Research
https://www.readbyqxmd.com/read/30019645/pivotal-pathogenic-and-biomarker-role-of-chlamydia-pneumoniae-in-neurovascular-diseases
#18
Seidu A Richard
Chlamydia Pneumoniae (C. Pn) is an obligatory intracellular bacterium that is associated with respiratory tract infections like pneumonia, pharyngitis and bronchitis. It has also been implicated in cerebrovascular (stroke) as well as cardiovascular diseases. The most possible pathway via which C. Pn elicits its pathogenesis could be via activation of Human Vascular Smooth Muscle Cells (VSMCs) proliferation resulting in the stimulation of Toll-Like Receptor-4 (TLR-4) and/or phospho-44/42(p44/p42) Mitogen-Activated Protein Kinases (MAPK)...
2018: Current Neurovascular Research
https://www.readbyqxmd.com/read/30014803/recombinant-tissue-plasminogen-activator-in-acute-ischemic-stroke-patients-receiving-thrombectomy-standard-or-low-dose-therapy
#19
Chun-Hsien Lin, Chi-Hung Liu, Alvin Yi-Chou Wang, Yi-Ming Wu, Ching-Chang Chen, Yuan-Hsiung Tsai, Ting-Yu Chang, Kuo-Lun Huang, Hsiu-Chuan Wu, Tsong-Hai Lee, Yeu-Jhy Chang, Chuan-Min Lin, Chih-Kuang Cheng, Chien-Hung Chang
BACKGROUND: We compared the clinical outcomes of low and standard dose recombinant tissue Plasminogen Activator (rtPA) treatment in Acute Ischemic Stroke (AIS) patients receiving Endovascular Mechanical Thrombectomy (EVT). METHODS: Between April 01, 2015 and September 30, 2017, all AIS patients admitted to the Linkou and Chiayi Chang Gung Memorial Hospital were retrospectively reviewed. Patients with large vessel occlusions, who underwent bridging therapy with rtPA and EVT, were further enrolled...
2018: Current Neurovascular Research
https://www.readbyqxmd.com/read/30003853/-micromanaging-glioblastoma-multiforme-the-potential-of-micrornas-circular-rnas-and-the-hippo-pathway-as-novel-treatment-strategies
#20
EDITORIAL
Kenneth Maiese
No abstract text is available yet for this article.
2018: Current Neurovascular Research
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