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Current Neurovascular Research

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https://www.readbyqxmd.com/read/29623838/mir-29-targets-puma-to-suppress-oxygen-and-glucose-deprivation-reperfusion-ogd-r-induced-cell-death-in-hippocampal-neurons
#1
Rong Wei, Rufang Zhang, Hongmei Li, Hongyun Li, Saiji Zhang, Yewei Xie, Shen Li, Fang Chen
We previously demonstrate that microRNAs (miRNA) play an important role in hypothermic circulatory arrest (DHCA)-associated neural injury. However, the specific role of miRNAs in the pathogenesis of DHCA-induced neuron death is still unclear. Thus, in the present study, we investigated miR-29 expression and roles in neuronal HT-22 cells with oxygen-glucose deprivation/reoxygenation (OGD/R). In this study, the model of OGD/R was established using an airtight culture container and the anaeropack. Measurement of reactive oxygen species (ROS) production and mitochondrial membrane potential (MMP) was used the probes of JC-1 and H2DCFDA...
April 3, 2018: Current Neurovascular Research
https://www.readbyqxmd.com/read/29595109/levosimendan-reduces-prostaglandin-f2a-dependent-vasoconstriction-in-physiological-vessels-and-after-experimentally-induced-subarachnoid-hemorrhage
#2
Stefan Wanderer, Jan Mrosek, Florian Gessler, Volker Seifert, Juergen Konczalla
Background Delayed cerebral vasospasm (dCVS) following aneurysmal subarachnoid hemorrhage (aSAH) is (next to possible aneurysm rebleeding, cortical spreading depression and early brain injury) one of the main factors contributing to poor overall patient outcome. Since decades intensive research has been ongoing with the goal of improving our understanding of the pathophysiological principles underlying dCVS. Endothelin-1 (ET-1) and prostaglandin F2 alpha (PGF2a) seem to play a major role during dCVS. The synthesis of ET-1 is enhanced after subarachnoid hemorrhage (SAH) to mediate a long-lasting vasoconstriction, and PGF2a contributes to cerebral inflammation and vasoconstriction...
March 28, 2018: Current Neurovascular Research
https://www.readbyqxmd.com/read/29589545/a-sweeping-role-for-micrornas-in-neuronal-disease-vascular-disorders-and-as-prognostic-indicators
#3
EDITORIAL
Kenneth Maiese
No abstract text is available yet for this article.
March 27, 2018: Current Neurovascular Research
https://www.readbyqxmd.com/read/29577862/increased-arterial-stiffness-is-associated-with-poor-collaterals-in-acute-ischemic-stroke-from-large-vessel-occlusion
#4
Maurizio Acampa, Daniele Giuseppe Romano, Pietro Enea Lazzerini, Sara Leonini, Francesca Guideri, Rossana Tassi, Tommaso Casseri, Sandra Bracco, Giuseppe Martini
BACKGROUND: Cerebral collateral circulation is a network of arterial anastomotic channels capable of providing supplementary perfusion to brain regions in response to ischemic insults. Arterial stiffness could negatively affect collateral circulation development, by means of its effects on structural intracerebral vasculature. OBJECTIVE: The aim of our study is to investigate a possible link between arterial stiffness and presence of collateral circulation in patients with acute ischemic stroke...
March 25, 2018: Current Neurovascular Research
https://www.readbyqxmd.com/read/29577861/kidney-dysfunction-is-associated-with-a-high-burden-of-cerebral-small-vessel-disease-in-primary-intracerebral-hemorrhage
#5
Mangmang Xu, Shihong Zhang, Jiaqi Liu, Simiao Wu, Yajun Cheng, Ming Liu
OBJECTIVES: To investigate the association of kidney function with the total burden of cerebral small vessel disease (CSVD) in primary intracerebral hemorrhage (pICH). METHODS: Cerebral magnetic resonance imaging of consecutively enrolled pICH patients was reviewed to assess for lacunes, white matter hyperintensity (WMH), cerebral microbleeds (CMBs) and enlarged perivascular spaces (EPVS). Minor refinements to the CSVD score, namely modified CSVD score 1 and 2, were made by incorporating different weightings of CSVD markers...
March 25, 2018: Current Neurovascular Research
https://www.readbyqxmd.com/read/29577860/prognostic-value-of-white-blood-cell-counts-and-c-reactive-protein-in-acute-ischemic-stroke-patients-after-intravenous-thrombolysis
#6
Jijun Shi, Xinyuan Qu, Yongjun Cao, Mingzhi Zhang, Jiaping Xu
BACKGROUND: The prognostic value of white blood cell (WBC) counts and C-reactive protein (CRP) in clinical outcomes of acute ischemic stroke (AIS) patients after intravenous thrombolysis (IVT) remains unknown. We investigated the association of WBC counts and CRP with 3-month functional outcomes and all-cause mortality in AIS patients. METHODS: 447 AIS patients treated with IVT between May 2010 and May 2017 were enrolled. WBC counts and CRP were measured within the 24 hours after IVT...
March 25, 2018: Current Neurovascular Research
https://www.readbyqxmd.com/read/29557749/novel-treatment-strategies-for-the-nervous-system-circadian-clock-genes-non-coding-rnas-and-forkhead-transcription-factors
#7
Kenneth Maiese
BACKGROUND: With the global increase in life span expectancy, neurodegenerative disorders continue to affect an ever increasing number of individuals throughout the world. New treatment strategies for neurodegenerative diseases are desperately required given the lack of current treatment modalities. METHODS: Here we examine novel strategies for neurodegenerative disorders that include circadian clock genes, non-coding ribonucleic acids (RNAs), and the mammalian forkhead transcription factors of the O class (FoxOs)...
March 19, 2018: Current Neurovascular Research
https://www.readbyqxmd.com/read/29557748/changes-in-e-selectin-levels-predict-carotid-stenosis-progression-after-carotid-artery-stenting
#8
Chi-Hung Liu, Tsong-Hai Lee, Pi-Yueh Chang, Chien-Hung Chang, Hsiu-Chuan Wu, Ting-Yu Chang, Kuo-Lun Huang, Chih-Kuang Cheng, Yeu-Jhy Chang
BACKGROUND: We hypothesized the inflammatory markers (IM) could be independent predictors of carotid stenosis progression (CSP) after carotid artery stenting (CAS). METHODS: Between 2010 and 2012, 122 patients undergoing cervicocranial revascularization in our hospital were prospectively recruited. Patients undergoing revascularizations other than CAS were excluded. Carotid duplex ultrasonography was performed before and at 1 week, 6 months (6M), 1 year, and 2 years after CAS...
March 19, 2018: Current Neurovascular Research
https://www.readbyqxmd.com/read/29557747/blood-microrna-15a-correlates-with-il-6-igf-1-and-acute-cerebral-ischemia
#9
Wenjing Lu, Yang Wang, Yu Zhang, Huaibin Liang, Xuanqiang Tu, Jirong He, Guoyuan Yang, Lili Zeng
OBJECTIVE: To explore the function of blood microRNA-15a (miR-15a) in the pathogenesis of acute cerebral ischemia. METHODS: Blood samples were collected from acute ischemic stroke (AIS) patients within 72 h after onset and normal control healthy. A model of ischemia in human umbilical vein endothelial cells (HUVEC) was established by oxygen and glucose deprivation (OGD). MiR-15a in patients and in cells was measured by real-time quantitative polymerase chain reaction (qPCR)...
March 19, 2018: Current Neurovascular Research
https://www.readbyqxmd.com/read/29557746/significant-association-of-cxcl12-rs1746048-with-ldl-c-level-in-intracranial-aneurysm-in-han-chinese-female
#10
Junjun Zhang, Haoyuan Shen, Mengjun Wang, Sheng Nie, Xizheng Wu, Yi Huang, Xiang Gao
C-X-C motif chemokine ligand 12 (CXCL12) may play an important role in the development of intracranial aneurysm (IA). The goal of this study was to explore the association between CXCL12 rs1746048 genotypes and circulating lipid concentrations along with the risk of IA. A total of 256 IA patients and 361 healthy volunteers were included in the case-control study. The genotypes of CXCL12 rs1746048 were detected by Melting Temperature shift (Tm-shift) polymerase chain reaction (PCR). Significant higher levels were seen in TC (padjusted < 0...
March 19, 2018: Current Neurovascular Research
https://www.readbyqxmd.com/read/29557745/positron-emission-tomography-and-autoradiography-imaging-of-p-selectin-activation-using-68ga-fucoidan-in-photothrombotic-stroke-in-rats
#11
Ina Israel, Felix Fluri, Fabian Schadt, Adreas Buck, Samuel Samnick
BACKGROUND: P-selectin is activated early after stroke, followed by a rapid decline. This time course can be used to generate important information on stroke onset. The latter is crucial for therapeutic decision-making of wake-up strokes (i.e. thrombolysis or not). Here we evaluated the specific p-selectin inhibitor 68Ga-Fucoidan for assessing p-selectin activation after ischemic stroke using PET. METHODS: 68Ga-Fucoidan was investigated in rats brain at 2-5 h (n=16), and additionally at 24-26 h (n=9) and 48 h (n=3) after induction of photothrombic stroke or in sham operated animals (n=6)...
March 19, 2018: Current Neurovascular Research
https://www.readbyqxmd.com/read/29313467/temporal-expression-of-mutant-tdp-43-correlates-with-early-amyotrophic-lateral-sclerosis-phenotype-and-motor-weakness
#12
Qihua Chen, Jinxia Zhou, Cao Huang, Bo Huang, Fangfang Bi, Hongxia Zhou, Bo Xiao
BACKGROUND: Mutant transactive response DNA-binding protein (TDP-43) is closely correlated to inherited form of amyotrophic lateral sclerosis (ALS). TDP-43 transgenic rats can reproduce the core phenotype of ALS and constitutive expression of TDP-43 caused postnatal death. OBJECTIVE: To understand whether neurologic deficiency caused by mutant TDP-43 is dependent on its temporal expression. METHOD: Transgenic rats were established that express mutant human TDP-43 (M337V substitution) in neurons, then a Tet-off system was used to regulate its expression...
January 9, 2018: Current Neurovascular Research
https://www.readbyqxmd.com/read/29149834/cystatin-c-in-cerebrovascular-disorders
#13
Yaru Zhang, Li Sun
Cystatin C (CysC), a cysteine protease inhibitor, has been widely proven to be a highly sensitive biomarker to predict the kidney function. The similarity of the renal and cerebral small vessels has awakened a surge of studies suggesting that CysC plays a key role in various cerebrovascular disorders. This review focuses on four major mechanisms of CysC in a variety of cerebrovascular diseases. (1)The property of the CysC Leu-68-Gln (L68Q) variant to aggregate and the property of the wild type CysC protein to co-aggregate with Amyloid-β (Aβ); (2)The disruption of equilibrium between CysC and related cysteine proteases; (3)The function of CysC as an inflammatory inducing factor; (4)The ability of CysC to induce autophagy...
November 15, 2017: Current Neurovascular Research
https://www.readbyqxmd.com/read/29119925/post-treatment-with-a-hydrogen-sulfide-donor-limits-neuronal-injury-and-modulates-potassium-voltage-gated-channel-subfamily-d-member-2-kv4-2-and-potassium-channel-interacting-protein-3-kchip3-during-transient-global-cerebral-ischemia
#14
Cheng-Ping Bai, ChenLiang Zhao, Lijuan Shen
BACKGROUND: Although the neuroprotective effect of sodium hydrosulfide (NaHS, a hydrogen sulfide donor) pretreatment has been revealed, the effect of NaHS post-conditioning remains largely unknown. OBJECTIVE: We aimed to investigate the neuroprotective effect of NaHS post-conditioning against transient global cerebral ischemia (tGCI)-induced hippocampal CA1 injury and its underlying molecular mechanism. METHODS: A tGCI rat model was established using the four-vessel occlusion method for 15 min of ischemia...
November 7, 2017: Current Neurovascular Research
https://www.readbyqxmd.com/read/29090669/mir-132-down-regulates-methyl-cpg-binding-protein-2-mecp2-during-cognitive-dysfunction-following-chronic-cerebral-hypoperfusion
#15
Zhao-Hui Yao, Xiao-Li Yao, Yong Zhang, Shao-Feng Zhang, Jichang Hu
BACKGROUND: Chronic Cerebral Hypoperfusion (CCH) is an important vascular risk factor for vascular-related dementia cognitive impairment and there are no effective measures for the prevention and treatment of cognitive deficit by CCH and the underlying mechanisms are still poorly understood. Methyl cytidine-phosphate-guanosine (CpG) binding protein 2 (MeCP2), regulated by microRNA 132 (miR-132), is as a transcriptional repressor in high concentrations in the brain, regulates the expression of synaptic proteins and neuroplasticity, and may be involved in the cognitive deficit after CCH...
November 1, 2017: Current Neurovascular Research
https://www.readbyqxmd.com/read/29076429/salvianolate-blocks-apoptosis-during-myocardial-infarction-by-down-regulating-mir-122-5p
#16
Jingyang Lin, Xiaochun Zheng
BACKGROUND: Recent studies have provided evidence that microRNAs (miRNAs), as a potential biomarker, were involved in the regulation of gene expression in Myocardial Infarction (MI). This study was aim to highlight the role of salvianolate on cardiomyocyte apoptosis in MI. METHODS: Anterior descending branch of left coronary artery was ligated to set up MI model. miR-122-5p mimic was transfected into cardiomyocytes and verified by quantitative real-time PCR (qRT-PCR)...
October 26, 2017: Current Neurovascular Research
https://www.readbyqxmd.com/read/29046152/cerebral-small-vessel-disease-is-associated-with-genetic-variations-in-cyp2j
#17
Ming Yao, Daping Lv, Jiajia Huo, Zhongwu Sun
BACKGROUND: Cerebral small vessel disease (SVD) can cause cognitive impairment, disability, and dementia. While it's still unclear about the pathogenesis of SVD, several risk factors of SVD have been identified, and studies suggested that hypertension may play a critical role in SVD. Furthermore, studies have demonstrated that CYP2J2 isoform, 50 G>T variant, is associated with increase the risk of ischemic stroke. Thus, we hypothesized that CYP2J2 50 G>T variant is associated with increased risk of cerebral SVD...
October 17, 2017: Current Neurovascular Research
https://www.readbyqxmd.com/read/28990533/blood-brain-barrier-disruption-leads-to-postoperative-cognitive-dysfunction
#18
Bin Wang, Siyuan Li, Xipeng Cao, Xinghui Dou, Jingzhu Li, Ling Wang, Mingshan Wang, Yanlin Bi
BACKGROUND: Postoperative cognitive dysfunction (POCD) has received considerable attention as one of the main postoperative complications. The underlying mechanism of POCD in elderly subjects has not been fully elucidated to date. The central nervous system (CNS) is isolated from the bloodstream by the blood brain barrier (BBB) that consists of endothelial cells, capillary blood vessels and the tight junctions. The tight junctions carry out significant biological functions that are associated with the CNS and the blood circulation...
October 9, 2017: Current Neurovascular Research
https://www.readbyqxmd.com/read/28982333/cerebral-artery-vasoconstriction-is-endothelin-1-dependent-requiring-neurogenic-and-adrenergic-crosstalk
#19
Roel H L Haeren, Sieuwke A Hartmans, Jo De Mey, Govert Hoogland, Jim Dings, Olaf E M G Schijns, Sander M J van Kuijk, Kim Rijkers, Paul Schiffers, Koo J van Overbeeke
BACKGROUND: The regulation of cerebral arterial vasomotor tone involves several mechanisms. The role of sympathetic nerves and the adrenergic neurotransmitter, noradrenaline (NA), has been subject of debate for decades. Moreover, the specific role of endothelin-1 (ET-1) in cerebral arterial vasoconstriction has not been elucidated to date. In this study, we evaluated the contribution of NA and ET-1 to cerebral artery vasoconstriction. METHODS: Arterial responses of rat middle cerebral arteries, and human pial cerebral arteries to cumulative concentrations of NA and ET-1, and to electrical field stimulation (EFS), were evaluated...
October 5, 2017: Current Neurovascular Research
https://www.readbyqxmd.com/read/28982332/asymmetric-cerebrovascular-collateral-supply-affects-cognition-in-patients-with-unilateral-carotid-artery-stenosis
#20
Kuo-Lun Huang, Ting-Yu Chang, Chien-Hung Chang, Ho-Ling Liu, Yeu-Jhy Chang, Chi-Hung Liu, Ho-Fai Wong, Yi-Ming Wu, Tsong-Hai Lee, Meng-Yang Ho
BACKGROUND: The time to maximum of the residue function (TMax) has been employed to identify the penumbra in acute ischemic stroke. Cognitive impairment in patients with carotid artery stenosis (CAS) has been attributed to chronic cerebral hypoperfusion. The study aimed to examine whether cognitive impairment can be detected based on a preliminary TMax cutoff in patients with unilateral CAS. METHODS: Fifty unilateral CAS patients underwent dynamic susceptibility contrast MR perfusion...
October 5, 2017: Current Neurovascular Research
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