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Current Neurovascular Research

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https://www.readbyqxmd.com/read/27897112/harnessing-the-power-of-sirt1-and-non-coding-rnas-in-vascular-disease
#1
Kenneth Maiese
Noncommunicable diseases (NCDs) contribute to a significant amount of disability and death in the world. Of these disorders, vascular disease is ranked high, falls within the five leading causes of death, and impacts multiple other disease entities such as those of the cardiac system, nervous system, and metabolic disease. Targeting the silent mating type information regulation 2 homolog 1 (Saccharomyces cerevisiae) (SIRT1) pathway and the modulation of micro ribonucleic acids (miRNAs) may hold great promise for the development of novel strategies for the treatment of vascular disease since each of these pathways are highly relevant to cardiac and nervous system disorders as well as to metabolic dysfunction...
November 29, 2016: Current Neurovascular Research
https://www.readbyqxmd.com/read/27897111/aggressive-antioxidant-reductive-stress-impairs-brain-endothelial-cell-angiogenesis-and-blood-brain-barrier-function
#2
Shireen Mentor, David Fisher
Oxidative stress in the brain microvasculature is a common characteristic in models of cerebrovascular disease. Considering the effects of reactive oxygen species activity in vascular-derived insults, it is naturally prudent to hypothesize those interventions inhibiting reactive oxygen species activity, such as antioxidant supplementation, may be beneficial for cerebrovascular disease. Hyper doses of antioxidant supplements, and foods with high antioxidant concentrations, are commonly used as an ongoing remedial and 'over-the-counter' treatments for most seasonal ailments...
November 29, 2016: Current Neurovascular Research
https://www.readbyqxmd.com/read/27890011/microrna-mir-130b-promotes-wear-particle-induced-osteolysis-via-down-regulating-frizzled-related-protein-frzb
#3
De-Zhi Zheng, Lei Wang, Yan-Min Bu, Jun Liu
Periprosthetic osteolysis induced by wear particles can lead to aseptic loosening, one main reason of arthroplasty failure. However, the role of microRNA-130b (miR-130b) in particle-induced osteolysis (PIO) has not been explored yet. In this study, PIO models were established in C57BL/J6 mice via the implantation of Co-Cr-Mo alloy particles, and evaluated by detecting tartrate-resistant acid phosphatase (TRAP) activity and bone resorption in the calvaria. Mouse preosteoblast MC3T3-E1 cells were cultured to receive particle stimulation in vitro...
November 23, 2016: Current Neurovascular Research
https://www.readbyqxmd.com/read/27890010/biological-function-and-mechanism-of-bone-marrow-mesenchymal-stem-cells-packed-poly-3-4-ethylenedioxythiophene-pedot-scaffolds-for-peripheral-nerve-injury-the-involvement-of-mir-21-notch-signaling-pathway
#4
Wenliang Wu, Shijun Zhang, Yunzhen Chen, Haichun Liu
Ununited peripheral nerves represent attractive site for connectivity with neuroprostheses because of their predictable internal topography allows for precise sorting of motor and sensory signals. Also transplantation of bone marrow mesenchymal stem cells (BMSCs) is increasingly recognized as an effective method of restore the peripheral nervous system injury due to its neuron-directed differentiation potential. This study was to evaluate the in vivo performance of BMSCs-packed Poly(3,4-ethylenedioxythiophene) (PEDOT) scaffolds across a critical nerve conduction gap and examine the potential mechanism by which BMSCs-packed PEDOT scaffolds mediates peripheral nerve regeneration in rat model of recurrent laryngeal nerve (RLN) deletion...
November 23, 2016: Current Neurovascular Research
https://www.readbyqxmd.com/read/27855593/protective-effect-of-bendavia-ss-31-against-oxygen-glucose-deprivation-stress-induced-mitochondrial-damage-in-human-brain-microvascular-endothelial-cells
#5
Takahiko Imai, Keisuke Mishiro, Toshinori Takagi, Aoi Isono, Hideko Nagasawa, Kazuhiro Tsuruma, Masamitsu Shimazawa, Hideaki Hara
Mitochondria play a key role in cell survival by perfoming functions such as adenosine tri-phosphate (ATP) synthesis, regulation of apoptotic cell death, calcium storage. Hypoxic conditions induce mitochondrial dysfunction, which leads to endothelial injury in cerebral ischemia. Functional disorders include the following: collapse of mitochondrial membrane potential, reduction of ATP synthesis, and generation of reactive oxygen species (ROS). Bendavia, a novel tetra-peptide, has been reported to restrict the uncoupling of the mitochondrial membrane chain, protect the synthesis of ATP, and inhibit ROS generation...
November 17, 2016: Current Neurovascular Research
https://www.readbyqxmd.com/read/27823553/neuro-psychological-pattern-in-patients-suffering-from-primitive-dilated-cardiomyopathy-with-impairment-in-executive-function
#6
Rosa Carbonara, Francesco Giardinelli, Annapaola Zito, Enrico Piccinelli, Pietro Scicchitano, Ilaria Dentamaro, Francesca Cortese, Agnese Armenise, Fabio Manca, Maria Fara De Caro, Pietro Nazzaro, Francesco Federico, Andrea Igoren Guaricci, Francesca Laudadio, Massimo Iacoviello, Marco Matteo Ciccone
According to the American Heart Association (AHA) , primitive dilated cardiomyopathy (PDCM) is a "progressive dilation of the left or both ventricles and a depressed contractility in absence of abnormal load conditions ". It evolves in progressive heart-failure. The term "cardiogenic dementia" expresses the intimate connection between heart diseases and cognitive functions. The association between PDCM and the neuropsychological functions is unclear: the main pathophysiological hypotheses are cerebral hypoperfusion and cardiogenic emboli...
November 6, 2016: Current Neurovascular Research
https://www.readbyqxmd.com/read/27823555/hypoxic-preconditioning-increased-blood-brain-barrier-disruption-in-the-early-stage-of-cerebral-ischemia
#7
Oak Z Chi, Scott J Mellender, Sylviana Barsoum, Xia Liu, Harvey R Weiss
Even though hypoxic preconditioning has been reported to produce neuroprotection, its effect on blood-brain barrier (BBB) disruption in the early stages of cerebral ischemia within the therapeutic window is not clear. Since hypoxic preconditioning increases expression of vascular endothelial growth factor (VEGF) that modulates vascular permeability, the effects of hypoxic preconditioning and VEGF on BBB permeability were investigated after one hour of focal cerebral ischemia. Rats were exposed to 8% of oxygen for two hours or room air and then 24 hours later, permanent middle cerebral artery (MCA) occlusion was performed...
November 4, 2016: Current Neurovascular Research
https://www.readbyqxmd.com/read/27823554/topical-diclofenac-loaded-liposomes-ameliorate-laser-induced-choroidal-neovascularization-in-mice-and-non-human-primates
#8
Masamitsu Shimazawa, Yuki Inoue, Tomomi Masuda, Risako Onodera, Kohei Tahara, Yoshitaka Shimizu, Yasuhiko Mibe, Kazuhiro Tsuruma, Hirofumi Takeuchi, Hideaki Hara
This study aimed to evaluate the effect of liposomes loaded with diclofenac, a potent cyclooxygenase (COX)-1 and COX-2 inhibitor, on laser-induced choroidal neovascularization (CNV) in mice and non-human primates (common marmosets). CNV was induced by laser irradiation on the unilateral or bilateral eye of each mouse or common marmoset, respectively, under anesthesia. The CNV was visualized using fluorescence labeling with intravenous injection of fluorescein-conjugated dextran (molecular weight = 2,000 kDa), and quantified in the retinal pigment epithelia (RPE)-choroidal flatmounts...
November 4, 2016: Current Neurovascular Research
https://www.readbyqxmd.com/read/27897113/strong-association-of-lipid-metabolism-related-microrna-binding-sites-polymorphisms-with-the-risk-of-late-onset-alzheimer-s-disease
#9
Lin Tan, Da-Long Zhao, Fu-Rong Sun, Meng-Shan Tan, Yu Wan, Chen-Chen Tan, Wei Zhang, Dan Miao, Jin-Tai Yu, Lan Tan
Although altered lipid metabolism has been extensively implicated in the pathogenesis of late onset Alzheimer's disease (LOAD) through cell biological and epidemiological studies, genetic studies linking lipid metabolism and LOAD are still not well understood. MicroRNAs (miRNAs) exert post-transcriptional down-regulation and their target sequence on the 3' untranslated regions (3'UTR) may be altered by single nucleotide polymorphisms (SNPs). We therefore explore whether the six loci in Clusterin gene (CLU) (rs9331949), Lipoprotein lipase gene (LPL) (rs1059507, rs3200218, rs3208305, rs3735964) and Low-density lipoprotein receptor related protein 6 (LRP6) (rs2160525) could modulate LOAD risk through the alteration of miRNA binding sites...
October 27, 2016: Current Neurovascular Research
https://www.readbyqxmd.com/read/27745542/fenofibrate-increases-heme-oxygenase-1-expression-and-astrocyte-proliferation-while-limits-neuronal-injury-during-intracerebral-hemorrhage
#10
Yan Wang, Min Yu, Yue Ma, Ruo Ping Wang, Wei Liu, Wei Xia, Ai Li Guan, Cong Hui Xing, Fei Lu, Xiao Ping Ji
Peroxisome proliferator-activated receptors alpha (PPARα) is a therapy target in atherosclerosis and cardiovascular diseases. However, anti-inflammatory effects of PPARα in intracerebral hemorrhage (ICH) remain unknown. We investigated the anti-inflammatory effects of fenofibrate, a ligand of PPARα, in ICH rat model. We found that engagement of fenofibrate increased nissl body and astrocytes, and reduced the neuronal damage, which was observed in paraffin section of ICH rat brain. Fenofibrate also promoted the proliferation of astrocytes that were isolated from adult rat brain...
October 14, 2016: Current Neurovascular Research
https://www.readbyqxmd.com/read/27599483/selective-modulator-of-cannabinoid-receptor-type-2-cb2-against-biochemical-alterations-and-brain-damage-in-chronic-cerebral-hypoperfusion-induced-vascular-dementia
#11
Shalini Jayant, Bhupesh Sharma
Vascular dementia is the second most common cause of cognitive decline in aged people but the effectual therapeutic target is still missing. Chronic cerebral hypoperfusion (CCH) has been widely found in vascular dementia (VaD) patients. CCH is thought to link with neurodegenerative disorders and their subsequent cognitive impairment. The present study has been framed to investigate the role of selective agonist of CB2 receptor (1-phenylisatin) in CCH induced VaD. Permanent bilateral common carotid arteries ligation or two vessels occlusion (2VO) technique was used to induce CCH in rats...
September 6, 2016: Current Neurovascular Research
https://www.readbyqxmd.com/read/27586843/selective-modulator-of-cannabinoid-receptor-type-2-reduces-memory-impairment-and-infarct-size-during-cerebral-hypoperfusion-and-vascular-dementia
#12
Shalini Jayant, Bhupesh Sharma
Vascular dementia is the highly devastating neurodegenerative disorder after Alzheimer's disease (AD) and mainly found in aged people but the effectual therapeutic target is still not there. Chronic cerebral hypoperfusion (CCH) has been broadly found in vascular dementia (VaD) patients. CCH is thought to link with neurodegenerative disorders and their subsequent cognitive deteriorate on. This study has been framed to examine the role of a selective agonist of cannabinoid receptor type 2(CB2); 1-phenylisatin in CCH induced VaD...
September 2, 2016: Current Neurovascular Research
https://www.readbyqxmd.com/read/27558201/fingolimod-fty720-reduces-cortical-infarction-and-neurological-deficits-during-ischemic-stroke-through-potential-maintenance-of-microvascular-patency
#13
Michael K Schuhmann, Miloš Krstić, Christoph Kleinschnitz, Felix Fluri
Fingolimod (FTY720) a functional sphingosine-1-phosphate receptor 1 (S1P1) antagonist reduces infarct volume and improves neurological deficits in different rodent stroke models by modulating inflammatory and immune processes. However, studies on FTY720 regarding its non-immunological efficacy on ischemic cerebral tissue are sparse. Here we investigated whether FTY720 has cytoprotective and restorative properties following ischemic stroke in mice. Male C57Bl/6 mice received FTY720 (1mg/kg) or a vehicle solution intraperitoneally immediately prior to transient middle cerebral artery occlusion (tMCAO; 30 min...
August 23, 2016: Current Neurovascular Research
https://www.readbyqxmd.com/read/27558200/activation-of-5-ht7-receptors-increases-the-nmda-receptor-mediated-mepscs-in-the-rat-visual-cortex
#14
Kangjian Xiang, Xuefei Zhao, Youjun Li, Liang Zheng, Jue Wang, Yan-Hai Li
Serotonin (5-hydroxytryptamine, 5-HT) is an important neurotransmitter that modulates N-methyl-D-aspartate (NMDA) receptor activity by binding to several different 5-HT receptor subtypes. In the present study, we used whole-cell patch-clamp recordings in transverse slice preparations to test the role of 5-HT receptors in modulating the NMDA receptor-mediated miniature excitatory postsynaptic currents (mEPSCs) in layer II/III pyramidal neurons of the rat visual cortex. We found that the NMDA receptor-mediated component of mEPSCs could be potentiated by exogenously applied 5-HT...
August 23, 2016: Current Neurovascular Research
https://www.readbyqxmd.com/read/27550504/vascular-patency-a-biomarker-and-clinical-target-quantified-with-high-resolution-mri-and-novel-cellular-pathways
#15
Kenneth Maiese
No abstract text is available yet for this article.
August 22, 2016: Current Neurovascular Research
https://www.readbyqxmd.com/read/27538891/intracranial-collateral-flow-estimated-by-color-velocity-imaging-quantification-ultrasound-a-protector-of-recurrent-stroke-in-patient-with-carotid-stenosis
#16
Hui Fang, Xiang Yan Chen, Bo Song, Bo Cheng, Yu Ming Xu, Ka Sing Wong, Stella Sin Yee Ho
BACKGROUND: Stroke patients with carotid disease have a high risk of recurrent. By measuring cerebral blood flow volume (BFV) using extracranial duplex technique for clinical estimation of intracranial collaterals, we aimed to investigate the relationship between the presence of intracranial collaterals and stroke recurrence in stroke patients with carotid disease. METHODS: Consecutive stroke patients indicated for carotid duplex ultrasound investigations in our hospital were recruited during three years' period...
August 16, 2016: Current Neurovascular Research
https://www.readbyqxmd.com/read/27538890/high-serum-alkaline-phosphatase-levels-in-relation-to-multi-cmbs-in-acute-ischemic-stroke-patients-with-atrial-fibrillation-and-or-rheumatic-heart-disease
#17
Junfeng Liu, Deren Wang, Jie Li, Yao Xiong, Bian Liu, Chenchen Wei, Simiao Wu, Ming Liu
Background and Objective Elevated alkaline phosphatase (ALP) levels are associated with cerebral small vascular diseases, such as silent brain infarction and cerebral white matter hyperintensity, but few prospective data are available for cerebral microbleeds (CMBs). The aim of the study was to investigate associations between serum ALP levels and CMBs in acute ischemic stroke patients with atrial fibrillation and/or rheumatic heart disease. Methods This prospective study involved consecutively recruited acute ischemic stroke patients with atrial fibrillation and/or rheumatic heart disease treated at two large tertiary care hospitals in southwestern China...
August 16, 2016: Current Neurovascular Research
https://www.readbyqxmd.com/read/27501831/trem2-p-h157y-variant-and-the-risk-of-alzheimer-s-disease-a-meta-analysis-involving-14-510-subjects
#18
Teng Jiang, Jian-Kang Hou, Qing Gao, Jin-Tai Yu, Jun-Shan Zhou, Hong-Dong Zhao, Ying-Dong Zhang
We recently revealed that p.H157Y (rs2234255), a rare coding variant of TREM2, was associated with Alzheimer's disease (AD) susceptibility in Han Chinese. Contrastingly, although p.H157Y was previously identified in both AD cases and controls by several sequencing studies, no association of this variant with disease susceptibility was reported. To gain a credible conclusion on the association between p.H157Y and AD risk, a meta-analysis involving 7,102 cases and 7,408 controls was conducted. Our results indicated that p...
August 7, 2016: Current Neurovascular Research
https://www.readbyqxmd.com/read/27488211/erythropoietin-and-mtor-a-one-two-punch-for-aging-related-disorders-accompanied-by-enhanced-life-expectancy
#19
Kenneth Maiese
Life expectancy continues to increase throughout the world, but is accompanied by a rise in the incidence of non-communicable diseases. As a result, the benefits of an increased lifespan can be limited by aging-related disorders that necessitate new directives for the development of effective and safe treatment modalities. With this objective, the mechanistic target of rapamycin (mTOR), a 289-kDa serine/threonine protein, and its related pathways of mTOR Complex 1 (mTORC1), mTOR Complex 2 (mTORC2), proline rich Akt substrate 40 kDa (PRAS40), AMP activated protein kinase (AMPK), Wnt signaling, and silent mating type information regulation 2 homolog 1 (Saccharomyces cerevisiae) (SIRT1), have generated significant excitement for furthering novel therapies applicable to multiple systems of the body...
July 29, 2016: Current Neurovascular Research
https://www.readbyqxmd.com/read/27262300/trpa1-and-trpm8-receptors-may-promote-local-vasodilation-that-aggravates-oxaliplatin-induced-peripheral-neuropathy-amenable-to-17%C3%AE-estradiol-treatment
#20
Yuwei Pan, Si Huang, Zejian Cai, Hai Lan, Yi Tong, Xuan Yu, Guoping Zhao, Fengguo Chen
Oxaliplatin is a widely used chemotherapeutic agent that induces both acute and chronic peripheral neuropathy. Based on previous research indicating that estrogen replacement may attenuate some forms of pain in ovariectomized animals, we examined the effects of 17β-estradiol in OXAIPN. We discovered that local cold exposure induces an abnormal vascular response in both acute and chronic models of OXAIPN (oxaliplatin-induced peripheral neuropathy) that may be used as an easy and non-invasive method to predict which patients may be susceptible to the development of severe, chronic OXAIPN...
June 1, 2016: Current Neurovascular Research
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