Read by QxMD icon Read

Current Neurovascular Research

Monika Golab-Janowska, Edyta Paczkowska, Boguslaw Machalinski, Agnieszka Meller, Dariusz Kotlega, Krzysztof Safranow, Pawel Wankowicz, Przemyslaw Nowacki
BACKGROUND: Endothelial progenitor cells (EPCs) have been suggested to be a therapeutic option in acute ischemic stroke (AIS). Statins modulate endothelial function and preserve blood flow to tissue exposed to an ischemic insult. We tested the hypothesis that statins therapy might augment circulating EPCs in patients with AIS. METHODS: Demographic data, classical vascular risk factors, treatment and National Institutes of Health Stroke Scale data were prospectively collected from 43 consecutive AIS patients (group I), comprising - 30 treated with statins ( group Statin(+)) and 13 untreated (group Statin (-))...
June 11, 2018: Current Neurovascular Research
Tongya Yu, Yingying Lin, Aiping Jin, Pei Zhang, Xiaoyu Zhou, Min Fang, Xueyuan Liu
OBJECTIVE: In this study, we aimed to evaluate the safety and efficiency of low dose intra-arterial tirofiban in mechanical thrombectomy of acute ischemic stroke patients to facilitate the reperfusion of distal vessel. METHODS: We retrospectively analyzed 54 consecutive acute ischemic patients who underwent mechanical thrombectomy for large-vessel occlusion. Patients were divided into two groups based on whether intra-arterial tirofiban was used during mechanical thrombectomy to facilitate the reperfusion of distal vessel...
June 4, 2018: Current Neurovascular Research
Yi Yang, Ning Zhang, Shan Wang, Ya Wen
Our previous work has indicated that miR-155 expression induces inflammatory responses in ischemic cerebral tissues. However, the delicate regulation of miR-155-modifed inflammatory responses has remained enigmatic. In the present study, we found that autophagy is induced by ischemia through miR-155 and involved in neural injury.Subsequently, miR-155-induced autophagy modifies inflammatory responses through regulating TLR4/NF-κB pathway in ischemic cerebral tissues. Thus, miR-155 elevated autophagy is detrimental for ischemic cerebral injury and miR-155-induced autophagy modulates inflammatory responses through activating TLR4/NF-κB pathway...
May 31, 2018: Current Neurovascular Research
Nivedita Agarwal, Christian Contarino, Nicola Limbucci, Laura Bertazzi, Eleuterio Toro
OBJECTIVE: Idiopathic intracranial hypertension (IIH) is a condition of unknown etiology frequently associated with dural sinus stenosis. There is emerging evidence that venous sinus stenting is an effective treatment. We use phase contrast cine MRI to observe changes in flow dynamics of multiple intracranial fluids and their response to different treatments in a patient with IIH. METHODS: we quantified the following parameters at the level of the aqueduct of Sylvius and the cervical C2C3: cerebrospinal fluid (CSF), arterial and venous flow; CSF velocity amplitude; artero-venous delay (AVD); artero-CSF delay and percentage of venous outflow normalized to total arterial inflow (tIJV/tA)...
May 27, 2018: Current Neurovascular Research
Min Tang, Xia Li, Ping Liu, Jianwen Wang, Fangping He, Xiongchao Zhu
BACKGROUND: Kinins are pro-inflammatory peptides that mediate numerous vascular and pain responses in tissue injury. Kinins exert their biological functions via two G-protein-coupled receptors: bradykinin 1 receptor (B1R) and bradykinin 2 receptor (B2R). We previously demonstrated the up-regulation of B2R after hypoxia/reoxygenation (H/R) injury in primary cultured cortical neurons. However, the role of B2R in inflammasome-induced pyroptosis remains unknown. METHODS: We induced H/R neuronal injury in primary cultured cortical neurons harvested from embryonic day 17 brains...
May 27, 2018: Current Neurovascular Research
Xinyu Li, Jingxin Li, Yafen Wei, Lihong Zhou, Ping Yin, Yongdan Liu, Shanshan Wu, Li Liu, Chong Lu
BACKGROUND--The purpose of the present study was to investigate the effects of onjisaponin B (OB) in lipopolysaccharide (LPS)-induced cognitive deficits. METHODS--The rats were divided into four groups: sham group, LPS group (the model group), LPS + OB (1 mg/kg) group, LPS + OB (2 mg/kg) group. OB were treated three days before surgery and thereafter continuously for 7 days. Three days later, rats were intracerebroventricularly injected with LPS. The levels of inflammatory cytokines, and the capability of free radial scavenging in serum and hippocampus were determined after the LPS challenge...
May 27, 2018: Current Neurovascular Research
Yen-Chu Huang, Yuan-Hsiung Tsai, Jiann-Der Lee, Jen-Tsung Yang, Yi-Ting Pan
OBJECTIVE: In acute ischemic stroke, early neurological deterioration (END) may occur in up to one-third of patients. However, there is still no satisfying or comprehensive predictive model for all the stroke subtypes. We propose a practical model to predict END using magnetic resonance imaging (MRI). METHOD: Patients with anterior circulation infarct were recruited and they underwent an MRI within 24 hours of stroke onset. END was defined as an elevation of ≥2 points on the National Institute of Health Stroke Scale (NIHSS) within 72 hours of stroke onset...
May 16, 2018: Current Neurovascular Research
Chen-Shu Chang, Shih-Li Su, Chen-Ling Kuo, Ching-Shan Huang, Wan-Min Tseng, Song-Shei Lin, Chin-San Liu
BACKGROUND: Cyclophilin A plays a pathogenic role in the development and progression of atherosclerosis, which can be assessed by measuring carotid intima-media thickness. The primary aim of this study was to examine the interaction between plasma Cyclophilin A level and carotid intima-media thickness in patients with acute ischemic stroke. METHOD: Plasma concentration of Cyclophilin A was measured on admission in 66 consecutive patients who had been hospitalized for acute cerebral stroke and in 52 case-control subjects without a history of acute stroke...
May 16, 2018: Current Neurovascular Research
Kaili Wang, Yu Zhang, Chongke Zhong, Jiaping Xu, Yanlin Zhang, Jijun Shi, Goudong Xiao, Xia Zhang, Huihui Liu, Zhichao Huang, Chun-Feng Liu, Shoujiang You, Yongjun Cao
BACKGROUND: The impact of total bile acids (TBA) level on clinical outcomes after acute intracerebral hemorrhage (ICH) is still not understood. OBJECTIVE: We investigated whether admission TBA level is associated with hematoma volume, stroke clinical severity, and 3-month outcomes in acute ICH patients. METHODS: A total of 335 ICH patients were prospectively enrolled. Patients were divided into four groups, according to the quartiles of serum TBA level at the time of admission...
May 15, 2018: Current Neurovascular Research
Kenneth Maiese
No abstract text is available yet for this article.
May 10, 2018: Current Neurovascular Research
Rong Wei, Rufang Zhang, Hongmei Li, Hongyun Li, Saiji Zhang, Yewei Xie, Shen Li, Fang Chen
We previously demonstrate that microRNAs (miRNA) play an important role in hypothermic circulatory arrest (DHCA)-associated neural injury. However, the specific role of miRNAs in the pathogenesis of DHCA-induced neuron death is still unclear. Thus, in the present study, we investigated miR-29 expression and roles in neuronal HT-22 cells with oxygen-glucose deprivation/reoxygenation (OGD/R). In this study, the model of OGD/R was established using an airtight culture container and the anaeropack. Measurement of reactive oxygen species (ROS) production and mitochondrial membrane potential (MMP) was used the probes of JC-1 and H2DCFDA...
April 3, 2018: Current Neurovascular Research
Stefan Wanderer, Jan Mrosek, Florian Gessler, Volker Seifert, Juergen Konczalla
Background Delayed cerebral vasospasm (dCVS) following aneurysmal subarachnoid hemorrhage (aSAH) is (next to possible aneurysm rebleeding, cortical spreading depression and early brain injury) one of the main factors contributing to poor overall patient outcome. Since decades intensive research has been ongoing with the goal of improving our understanding of the pathophysiological principles underlying dCVS. Endothelin-1 (ET-1) and prostaglandin F2 alpha (PGF2a) seem to play a major role during dCVS. The synthesis of ET-1 is enhanced after subarachnoid hemorrhage (SAH) to mediate a long-lasting vasoconstriction, and PGF2a contributes to cerebral inflammation and vasoconstriction...
March 28, 2018: Current Neurovascular Research
Kenneth Maiese
No abstract text is available yet for this article.
March 27, 2018: Current Neurovascular Research
Maurizio Acampa, Daniele Giuseppe Romano, Pietro Enea Lazzerini, Sara Leonini, Francesca Guideri, Rossana Tassi, Tommaso Casseri, Sandra Bracco, Giuseppe Martini
BACKGROUND: Cerebral collateral circulation is a network of arterial anastomotic channels capable of providing supplementary perfusion to brain regions in response to ischemic insults. Arterial stiffness could negatively affect collateral circulation development, by means of its effects on structural intracerebral vasculature. OBJECTIVE: The aim of our study is to investigate a possible link between arterial stiffness and presence of collateral circulation in patients with acute ischemic stroke...
March 25, 2018: Current Neurovascular Research
Mangmang Xu, Shihong Zhang, Jiaqi Liu, Hong Luo, Simiao Wu, Yajun Cheng, Ming Liu
OBJECTIVES: To investigate the association of kidney function with the total burden of cerebral small vessel disease (CSVD) in primary intracerebral hemorrhage (pICH). METHODS: Cerebral magnetic resonance imaging of consecutively enrolled pICH patients was reviewed to assess for lacunes, white matter hyperintensity (WMH), cerebral microbleeds (CMBs) and enlarged perivascular spaces (EPVS). Minor refinements to the CSVD score, namely modified CSVD score 1 and 2, were made by incorporating different weightings of CSVD markers...
March 25, 2018: Current Neurovascular Research
Xinyuan Qu, Jijun Shi, Yongjun Cao, Mingzhi Zhang, Jiaping Xu
BACKGROUND: The prognostic value of white blood cell (WBC) counts and C-reactive protein (CRP) in clinical outcomes of acute ischemic stroke (AIS) patients after intravenous thrombolysis (IVT) remains unknown. We investigated the association of WBC counts and CRP with 3-month functional outcomes and all-cause mortality in AIS patients. METHODS: 447 AIS patients treated with IVT between May 2010 and May 2017 were enrolled. WBC counts and CRP were measured within the 24 hours after IVT...
March 25, 2018: Current Neurovascular Research
Kenneth Maiese
BACKGROUND: With the global increase in life span expectancy, neurodegenerative disorders continue to affect an ever increasing number of individuals throughout the world. New treatment strategies for neurodegenerative diseases are desperately required given the lack of current treatment modalities. METHODS: Here we examine novel strategies for neurodegenerative disorders that include circadian clock genes, non-coding ribonucleic acids (RNAs), and the mammalian forkhead transcription factors of the O class (FoxOs)...
March 19, 2018: Current Neurovascular Research
Chi-Hung Liu, Tsong-Hai Lee, Pi-Yueh Chang, Chien-Hung Chang, Hsiu-Chuan Wu, Ting-Yu Chang, Kuo-Lun Huang, Chih-Kuang Cheng, Yeu-Jhy Chang
BACKGROUND: We hypothesized the inflammatory markers (IM) could be independent predictors of carotid stenosis progression (CSP) after carotid artery stenting (CAS). METHODS: Between 2010 and 2012, 122 patients undergoing cervicocranial revascularization in our hospital were prospectively recruited. Patients undergoing revascularizations other than CAS were excluded. Carotid duplex ultrasonography was performed before and at 1 week, 6 months (6M), 1 year, and 2 years after CAS...
March 19, 2018: Current Neurovascular Research
Wenjing Lu, Yang Wang, Yu Zhang, Huaibin Liang, Xuanqiang Tu, Jirong He, Guoyuan Yang, Lili Zeng
OBJECTIVE: To explore the function of blood microRNA-15a (miR-15a) in the pathogenesis of acute cerebral ischemia. METHODS: Blood samples were collected from acute ischemic stroke (AIS) patients within 72 h after onset and normal control healthy. A model of ischemia in human umbilical vein endothelial cells (HUVEC) was established by oxygen and glucose deprivation (OGD). MiR-15a in patients and in cells was measured by real-time quantitative polymerase chain reaction (qPCR)...
March 19, 2018: Current Neurovascular Research
Junjun Zhang, Haoyuan Shen, Mengjun Wang, Sheng Nie, Xizheng Wu, Yi Huang, Xiang Gao
C-X-C motif chemokine ligand 12 (CXCL12) may play an important role in the development of intracranial aneurysm (IA). The goal of this study was to explore the association between CXCL12 rs1746048 genotypes and circulating lipid concentrations along with the risk of IA. A total of 256 IA patients and 361 healthy volunteers were included in the case-control study. The genotypes of CXCL12 rs1746048 were detected by Melting Temperature shift (Tm-shift) polymerase chain reaction (PCR). Significant higher levels were seen in TC (padjusted < 0...
March 19, 2018: Current Neurovascular Research
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"