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Current Neurovascular Research

Yan Wang, Min Yu, Yue Ma, Ruo Ping Wang, Wei Liu, Wei Xia, Ai Li Guan, Cong Hui Xing, Fei Lu, Xiao Ping Ji
Peroxisome proliferator-activated receptors alpha (PPARα) is a therapy target in atherosclerosis and cardiovascular diseases. However, anti-inflammatory effects of PPARα in intracerebral hemorrhage (ICH) remain unknown. We investigated the anti-inflammatory effects of fenofibrate, a ligand of PPARα, in ICH rat model. We found that engagement of fenofibrate increased nissl body and astrocytes, and reduced the neuronal damage, which was observed in paraffin section of ICH rat brain. Fenofibrate also promoted the proliferation of astrocytes that were isolated from adult rat brain...
October 14, 2016: Current Neurovascular Research
Shalini Jayant, Bhupesh Sharma
Vascular dementia is the second most common cause of cognitive decline in aged people but the effectual therapeutic target is still missing. Chronic cerebral hypoperfusion (CCH) has been widely found in vascular dementia (VaD) patients. CCH is thought to link with neurodegenerative disorders and their subsequent cognitive impairment. The present study has been framed to investigate the role of selective agonist of CB2 receptor (1-phenylisatin) in CCH induced VaD. Permanent bilateral common carotid arteries ligation or two vessels occlusion (2VO) technique was used to induce CCH in rats...
September 6, 2016: Current Neurovascular Research
Shalini Jayant, Bhupesh Sharma
Vascular dementia is the highly devastating neurodegenerative disorder after Alzheimer's disease (AD) and mainly found in aged people but the effectual therapeutic target is still not there. Chronic cerebral hypoperfusion (CCH) has been broadly found in vascular dementia (VaD) patients. CCH is thought to link with neurodegenerative disorders and their subsequent cognitive deteriorate on. This study has been framed to examine the role of a selective agonist of cannabinoid receptor type 2(CB2); 1-phenylisatin in CCH induced VaD...
September 2, 2016: Current Neurovascular Research
ChunHsien Lin, Yuan-Hsiung Tsai, Jiann-Der Lee, Hsu-Huei Weng, Jen-Tsung Yang, Leng-Chieh Lin, Ya-Hui Lin, Chih-Ying Wu, Ying-Chih Huang, Huan-Lin Hsu, Meng Lee, Chia-Yu Hsu, Yi-Ting Pan, Yen-Chu Huang
Despite advances in imaging techniques and detailed examinations to determine the etiology of a stroke, the cause still remains undetermined in about one fourth of all ischemic strokes. The aim of this prospective study was to determine whether perfusion magnetic resonance imaging (MRI) can differentiate cardioembolic stroke from large artery atherosclerosis (LAA). We recruited 17 cardioembolic stroke and 22 LAA stroke patients, who were classified according to the Trial of Org 10172 in Acute Stroke Treatment and underwent perfusion MRI within 24 hours after the onset of stroke...
September 1, 2016: Current Neurovascular Research
Fei Li, Qian-Xue Chen, Zhi-Biao Chen, Dao-Feng Tian, Qiang Cai
Intracranial atherosclerosis may be related to the risk of ischemic stroke. High-resolution magnetic resonance imaging (H-R MRI) makes it possible to measure the intracranial atheroma in vivo. The aim of this study was to evaluate the plaque burden of the middle cerebral artery (MCA) using H-R MRI, and to determine its relationship with both cerebral infarction size and plaque burden in the carotid artery (CA). 54 patients with MCA territory infarction were enrolled and HR-MRI was performed within 7 days following stroke onset...
2016: Current Neurovascular Research
Michael K Schuhmann, Miloš Krstić, Christoph Kleinschnitz, Felix Fluri
Fingolimod (FTY720) a functional sphingosine-1-phosphate receptor 1 (S1P1) antagonist reduces infarct volume and improves neurological deficits in different rodent stroke models by modulating inflammatory and immune processes. However, studies on FTY720 regarding its non-immunological efficacy on ischemic cerebral tissue are sparse. Here we investigated whether FTY720 has cytoprotective and restorative properties following ischemic stroke in mice. Male C57Bl/6 mice received FTY720 (1mg/kg) or a vehicle solution intraperitoneally immediately prior to transient middle cerebral artery occlusion (tMCAO; 30 min...
August 23, 2016: Current Neurovascular Research
Kangjian Xiang, Xuefei Zhao, Youjun Li, Liang Zheng, Jue Wang, Yan-Hai Li
Serotonin (5-hydroxytryptamine, 5-HT) is an important neurotransmitter that modulates N-methyl-D-aspartate (NMDA) receptor activity by binding to several different 5-HT receptor subtypes. In the present study, we used whole-cell patch-clamp recordings in transverse slice preparations to test the role of 5-HT receptors in modulating the NMDA receptor-mediated miniature excitatory postsynaptic currents (mEPSCs) in layer II/III pyramidal neurons of the rat visual cortex. We found that the NMDA receptor-mediated component of mEPSCs could be potentiated by exogenously applied 5-HT...
August 23, 2016: Current Neurovascular Research
Kenneth Maiese
No abstract text is available yet for this article.
August 22, 2016: Current Neurovascular Research
Hui Fang, Xiang Yan Chen, Bo Song, Bo Cheng, Yu Ming Xu, Ka Sing Wong, Stella Sin Yee Ho
BACKGROUND: Stroke patients with carotid disease have a high risk of recurrent. By measuring cerebral blood flow volume (BFV) using extracranial duplex technique for clinical estimation of intracranial collaterals, we aimed to investigate the relationship between the presence of intracranial collaterals and stroke recurrence in stroke patients with carotid disease. METHODS: Consecutive stroke patients indicated for carotid duplex ultrasound investigations in our hospital were recruited during three years' period...
August 16, 2016: Current Neurovascular Research
Junfeng Liu, Deren Wang, Jie Li, Yao Xiong, Bian Liu, Chenchen Wei, Simiao Wu, Ming Liu
Background and Objective Elevated alkaline phosphatase (ALP) levels are associated with cerebral small vascular diseases, such as silent brain infarction and cerebral white matter hyperintensity, but few prospective data are available for cerebral microbleeds (CMBs). The aim of the study was to investigate associations between serum ALP levels and CMBs in acute ischemic stroke patients with atrial fibrillation and/or rheumatic heart disease. Methods This prospective study involved consecutively recruited acute ischemic stroke patients with atrial fibrillation and/or rheumatic heart disease treated at two large tertiary care hospitals in southwestern China...
August 16, 2016: Current Neurovascular Research
Teng Jiang, Jian-Kang Hou, Qing Gao, Jin-Tai Yu, Jun-Shan Zhou, Hong-Dong Zhao, Ying-Dong Zhang
We recently revealed that p.H157Y (rs2234255), a rare coding variant of TREM2, was associated with Alzheimer's disease (AD) susceptibility in Han Chinese. Contrastingly, although p.H157Y was previously identified in both AD cases and controls by several sequencing studies, no association of this variant with disease susceptibility was reported. To gain a credible conclusion on the association between p.H157Y and AD risk, a meta-analysis involving 7,102 cases and 7,408 controls was conducted. Our results indicated that p...
August 7, 2016: Current Neurovascular Research
Kenneth Maiese
Life expectancy continues to increase throughout the world, but is accompanied by a rise in the incidence of non-communicable diseases. As a result, the benefits of an increased lifespan can be limited by aging-related disorders that necessitate new directives for the development of effective and safe treatment modalities. With this objective, the mechanistic target of rapamycin (mTOR), a 289-kDa serine/threonine protein, and its related pathways of mTOR Complex 1 (mTORC1), mTOR Complex 2 (mTORC2), proline rich Akt substrate 40 kDa (PRAS40), AMP activated protein kinase (AMPK), Wnt signaling, and silent mating type information regulation 2 homolog 1 (Saccharomyces cerevisiae) (SIRT1), have generated significant excitement for furthering novel therapies applicable to multiple systems of the body...
July 29, 2016: Current Neurovascular Research
Yuwei Pan, Si Huang, Zejian Cai, Hai Lan, Yi Tong, Xuan Yu, Guoping Zhao, Fengguo Chen
Oxaliplatin is a widely used chemotherapeutic agent that induces both acute and chronic peripheral neuropathy. Based on previous research indicating that estrogen replacement may attenuate some forms of pain in ovariectomized animals, we examined the effects of 17β-estradiol in OXAIPN. We discovered that local cold exposure induces an abnormal vascular response in both acute and chronic models of OXAIPN (oxaliplatin-induced peripheral neuropathy) that may be used as an easy and non-invasive method to predict which patients may be susceptible to the development of severe, chronic OXAIPN...
June 1, 2016: Current Neurovascular Research
Deng Min, Wang Xu-Feng
Vascular cognitive impairment with no dementia (VCIND) refers to a transitional state and will progress to dementia. Currently, effective medicines to control VCIND are surprisingly scarce. Acupuncture intervention is frequently advocated as an adjunct treatment for VCIND in recent studies. So the aim of this meta-analysis was to assess the clinical efficacy and safety of acupuncture for VCIND. The literature search was conducted in English and Chinese databases from inception until July 2015, and 15 study populations were included in the meta-analysis...
2016: Current Neurovascular Research
Chunyan Lei, Bo Wu, Ming Liu, Ge Tan, Quantao Zeng
CDATA[Whether original intracerebral hemorrhage (ICH) score can be used to predict clinical outcomes in patients with SMASH-U (structural vascular lesions, medication, cerebral amyloid angiopathy, systemic disease, hypertension, or undetermined) classification remains an open question. This study obtained data related to consecutive acute patients with ICH from 21 tertiary hospitals in China during January 2012 to December 2014. Using the SMASH-U method, patients were classified into 6 subtypes. Favorable functional outcome and mortality was obtained after ICH at the 3 months...
2016: Current Neurovascular Research
Chiung-Chyi Shen, Wen-Yu Cheng, Ming-Tsang Chiao, Yea-Jiuan Liang, Tsuo-Fei Mao, Bai-Shuan Liu
The expression levels of different vascular endothelial growth factor A (VEGF) isoforms are associated with the angiogenesis and the patient's prognoses in human cancers. Ribosomes specifically scan from 5' to 3' CUG initiation codon in the long 5'-untranslated region (5'-UTR) of the VEGF mRNA, resulting in the generation of high mol wt VEGF isoform [call large VEGF (L-VEGF)]. Alternative splicing of VEGF mRNA transcripts results in several isoforms with distinct properties that are dependent up their exon compositions...
2016: Current Neurovascular Research
Huan Lu, Xi-Chen Zhu, Hui-Fu Wang, Lei Cao, Meng-Shan Tan, Chen-Chen Tan, Teng Jiang, Jin-Tai Yu, Lan Tan
Recently, a single nucleotide polymorphism rs10498633 on solute carrier family 24 member 4 (SLC24A4) was revealed to be closely related to the risk of late-onset Alzheimer`s disease (LOAD) in a large genome-wide association study containing 74046 individuals in Caucasians. However, no study was performed to validate this relation in other ethnic populations, including Han Chinese. Therefore, we recruited 992 LOAD patients and 1358 age- and sex- matched healthy controls to validate the association between rs10498633 and LOAD susceptibility in Han Chinese...
2016: Current Neurovascular Research
Prabhat Singh, Surbhi Gupta, Bhupesh Sharma
BACKGROUND: Diseases of cardio, as well as the cerebrovascular system, are known as the primary possibility for deficits in cognitive processes and dementia of vascular nature. Endothelin-1 (ET-1) and its receptors are extensively expressed in brain. OBJECTIVE: The present study has been structured to explore the effects of bosentan, an ET-1 antagonist on two-kidneyone- clip: 2K1C method induced hypertension provoked vascular dementia (VaD). METHOD: 2K1C was modelled to induce renovascular hypertension...
2016: Current Neurovascular Research
Irene Ciancarelli, Daniela De Amicis, Caterina Di Massimo, Caterina Pistarini, Maria Giuliana Tozzi Ciancarelli
The prognostic role of increased mean platelet volume (MPV), as an indicator of platelet activation and large, more reactive platelets, in clinical and functional outcome of ischemic stroke is still conflicting. Studies are not currently available on the association between MPV and stroke recovery after neurorehabilitation. The relationship between MPV and clinical and functional outcome measures was assessed in twenty-four patients in the acute phase of first-ever ischemic stroke, and before and after 8-week intensive multifunctional neurorehabilitation...
2016: Current Neurovascular Research
Melanie Dittmeier, Kathrin Wassmuth, Michael K Schuhmann, Peter Kraft, Christoph Kleinschnitz, Felix Fluri
Dabigatran etexilate (DE), a direct-acting, oral inhibitor of thrombin, significantly reduces the risk of stroke compared with traditional anticoagulants, without increasing the risk of major bleeding. However, studies on the fate of cerebral tissue after ischemic stroke in patients receiving DE are sparse and the role of dabigatran-mediated reduction of thrombin in this context has not yet been investigated. Here, we investigated whether pretreatment with DE reduces thrombin-mediated pro-inflammatory mechanisms and leakage of the blood-brain barrier (BBB) following ischemic stroke in rats...
2016: Current Neurovascular Research
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