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Current Neurovascular Research

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https://www.readbyqxmd.com/read/30101705/microrna-490-5p-targets-ccnd1-to-suppress-cellular-proliferation-in-glioma-cells-and-tissue-through-cell-cycle-arrest
#1
Long Zhao, Xiaoping Tang, Renguo Luo, Jie Duan, Yuanchuan Wang, Binbin Yang
Backgoud Glioma is a type of tumor that start in the glial cells of brain and spine. However,the underlying molecular mechanisms of miRNAs dysregulation in glioma initiation and progression is largely unclear. Objective To further understand the molecular mechanism of miR-490-5P functions and how miR-490 regulated CCND1 function. Methods The expression of miR-490-5P in glioma tissues and cells were measured by qRT-PCR and ISH. Cell transfection is responsible for miR-490-5P overexpression and knockdown. CCK-8and clone formation assay are applicable to examine the capacity of glioma cells proliferation...
August 13, 2018: Current Neurovascular Research
https://www.readbyqxmd.com/read/30101704/calcineurin-inhibition-and-protein-kinase-a-activation-limits-cognitive-dysfunction-and-histopathological-damage-in-a-model-of-dementia-of-the-alzheimer-s-type
#2
Amit Kumar, Nirmal Singh
AIM: The present study was designed to investigate the outcome of combination of Calcineurin (CaN) inhibitor (Tacrolimus) and Protein Kinase A (PKA) activator (Forskolin), in mouse models of experimental dementia. METHODS: Streptozotocin [STZ, 3mg/kg, injected intracerebroventricular (i.c.v.)] was used to induce memory deficits in NIH mice, while aged mice separately taken served as a natural model of dementia. Morris water maze (MWM) test was employed to evaluate learning and memory of the animals...
August 13, 2018: Current Neurovascular Research
https://www.readbyqxmd.com/read/30062967/curcumin-reduces-neuronal-loss-and-inhibits-the-nlrp3-inflammasome-activation-in-an-epileptic-rat-model
#3
Qianchao He, Lingfei Jiang, Shanshan Man, Lin Wu, Yueqiang Hu, Wei Chen
Background Epilepsy is a chronic neurological disorder affecting an estimated 50 million people worldwide. Emerging evidences have accumulated over the past decades supporting the role of inflammation in the pathogenesis of epilepsy. Curcumin is a nature-derived active molecule demonstrating anti-inflammation efficacy. However, its effects on epilepsy and corresponding mechanisms remain elusive. Objective To investigate the effects of curcumin on epilepsy and its underlying mechanism. Method Forty Sprague Dawley rats were divided into four groups: (1) control group; (2) kainic acid (KA)-induced epilepsy group; (3) curcumin group; and (4) curcumin pretreatment before KA stimulation group...
July 30, 2018: Current Neurovascular Research
https://www.readbyqxmd.com/read/30051791/cerebral-inflow-and-outflow-discrepancies-in-severe-sudden-sensorineural-hearing-loss
#4
Andrea Ciorba, Mirko Tessari, Manuela Mazzoli, Valentina Tavoni, Francesco Sisini, Claudia Aimoni, Francesco Stomeo, Erica Menegatti, Stefano Pelucchi, Paolo Zamboni
Aim of this study is to evaluate whether cerebral inflow and outflow abnormalities, assessed by the means of a validated ultrasound model, could be associated to Sudden Sensorineural Hearing Losss (SSNHL). A total of 42 patients affected by severe SSNHL according to Clark, and 19 healthy volunteers matched by gender without any history of sudden hearing impairment have been included in this study. Patients and controls underwent EchocolorDoppler assessment of brain hemodynamics. All subjects affected by SSNHL were also assessed with Auditory Brainstem Responses (ABR) and Magnetic Resonance Imaging (MRI) in order to exclude retrocochlear pathology...
July 26, 2018: Current Neurovascular Research
https://www.readbyqxmd.com/read/30047329/reduced-hemoglobin-levels-combined-with-an-increased-plasma-concentration-of-vasoconstrictive-endothelin-1-are-strongly-associated-with-poor-outcome-during-acute-ischemic-stroke
#5
Agnieszka Meller, Monika Golab-Janowska, Edyta Paczkowska, Boguslaw Machalinski, Wioletta Pawlukowska, Przemyslaw Nowacki
The association of poor outcome and mortality with low levels of hemoglobin (Hb) and hematocrit (HcT) in patients admitted after acute ischemic stroke (IS) was recently demonstrated. The mechanisms behind this still remain unclear. Our study aims to find out whether mRNA expressions and plasma concentrations of endothelin-1 (ET-l), endothelin-2 (ET-2) and endothelin-3 (ET-3) remain different in IS sufferers with low HcT and Hb levels in comparison with those whose HcT i Hb levels during a severe IS episode remain within the norm...
July 25, 2018: Current Neurovascular Research
https://www.readbyqxmd.com/read/30019645/pivotal-pathogenic-and-biomarker-role-of-chlamydia-pneumoniae-in-neurovascular-diseases
#6
Seidu A Richard
Chlamydia pneumoniae(C.Pn) is an obligatory intracellular bacterium that is associated with respiratory tract infections like pneumonia, pharyngitis and bronchitis. It has also been implicated in cerebrovascular (stroke) as well as cardiovascular diseases. The most possible pathway via which C.Pn elicits its pathogenesis could be via activation of human vascular smooth muscle cells (VSMCs) proliferation resulting in the stimulation of toll like receptor-4 (TLR-4) and/or phospho-44/42(p44/p42) mitogen-activated protein kinases (MAPK)...
July 17, 2018: Current Neurovascular Research
https://www.readbyqxmd.com/read/30014803/recombinant-tissue-plasminogen-activator-in-acute-ischemic-stroke-patients-receiving-thrombectomy-standard-or-low-dose-therapy
#7
Chun-Hsien Lin, Chi-Hung Liu, Alvin Yi-Chou Wang, Yi-Ming Wu, Ching-Chang Chen, Yuan-Hsiung Tsai, Ting-Yu Chang, Kuo-Lun Huang, Hsiu-Chuan Wu, Tsong-Hai Lee, Yeu-Jhy Chang, Chuan-Min Lin, Chih-Kuang Cheng, Chien-Hung Chang
Background - We compared the clinical outcomes of low and standard dose recombinant tissue plasminogen activator (rtPA) treatment in acute ischemic stroke (AIS) patients receiving endovascular mechanical thrombectomy (EVT). Methods - Between April 01, 2015 and September 30, 2017, all AIS patients admitted to the Linkou and Chiayi Chang Gung Memorial Hospital were retrospectively reviewed. Patients with large vessel occlusions, who underwent bridging therapy with rtPA and EVT, were further enrolled. The enrolled patients were categorized into low (0...
July 16, 2018: Current Neurovascular Research
https://www.readbyqxmd.com/read/29998805/genetic-determinants-of-cerebral-arterial-adaptation-to-flow-loading
#8
Todd A Abruzzo, Yuko Kurosawa, Ondrej Choutka, Joseph F Clark, Danielle Caudell Stamper, Sharyl Martini, Stacie L Demel, Daniel Woo, Kunal B Karani, Gail J Pyne-Geithman
BACKGROUND: In animal models, flow-loading is a necessary and sufficient hemodynamic factor to express the cerebral aneurysm (CA) phenotype. Using a rat model, this study characterizes the molecular events that comprise the cerebral arterial response to flow-loading and reveals their significance relating to the CA phenotype. OBJECTIVE: To characterize the molecular events that underlie expansive remodeling of cerebral arteries in two genetically distinct inbred rat strains with differential susceptibility to flow-dependent cerebrovascular pathology...
July 12, 2018: Current Neurovascular Research
https://www.readbyqxmd.com/read/29998804/lncrna-malat1-is-neuroprotective-in-a-rat-model-of-spinal-cord-ischemia-reperfusion-injury-through-mir-204-regulation
#9
Xiuwen Wang, Changliang Peng, Ji Li, Dongjin Wu, Yong Qiao
Background This study was to investigate the neuroprotective effect of long non-coding RNAs Metastasis associated lung adenocarcinoma transcript-1 (lncRNA MALAT-1) in spinal cord Ischemic/Reperfusion injury (SCIRI). Methods Quantitative real-time PCR (RT-qPCR) was used to examine the expressions of MALAT1, miR-204 and Bcl-2, while western blot was performed to examine Bcl-2. Besides, apoptosis was evaluated by the percentage of cell viability and apoptotic cells. Neurological evaluation was performed by measuring hindlimb locomotor function...
July 12, 2018: Current Neurovascular Research
https://www.readbyqxmd.com/read/29998803/extracranial-to-intracranial-bypass-for-pressor-dependent-cerebrovascular-insufficiency-modified-classification-and-representative-case
#10
Daniel M Heiferman, John R Souter, Matthew R Reynolds, Douglas E Anderson, Joseph C Serrone
BACKGROUND: While some randomized clinical trials have reduced the indications for cerebral revascularization in the secondary prevention of ischemic stroke, a distinct subset of patients with blood pressure augmentation dependent cerebrovascular insufficiency due to large vessel occlusions remains unaddressed. With the recent paradigm shifts in acute ischemic stroke care, the role of extracranial to intracranial (EC-IC) bypass must be re-addressed when endovascular intervention is not a feasible option...
July 12, 2018: Current Neurovascular Research
https://www.readbyqxmd.com/read/30003853/-micromanaging-glioblastoma-multiforme-the-potential-of-micrornas-circular-rnas-and-the-hippo-pathway-as-novel-treatment-strategies
#11
EDITORIAL
Kenneth Maiese
No abstract text is available yet for this article.
July 11, 2018: Current Neurovascular Research
https://www.readbyqxmd.com/read/29998802/elevated-c-reactive-protein-and-depressed-high-density-lipoprotein-cholesterol-are-associated-with-poor-function-outcome-after-ischemic-stroke
#12
Xiaowei Zheng, Nimei Zeng, Aili Wang, Zhengbao Zhu, Chongke Zhong, Tan Xu, Tian Xu, Yanbo Peng, Hao Peng, Qunwei Li, Zhong Ju, Deqin Geng, Yonghong Zhang, Jiang He
AIMS: C-reactive protein is an established marker of inflammation that can impair the protective function of high density lipoprotein cholesterol (HDL-C). The combined effect of C-reactive protein and HDL-C on long-term outcomes in patients with stroke remains uncertain. METHODS: A total of 3124 acute ischemic stroke subjects from the China Antihypertensive Trial in Acute Ischemic Stroke (CATIS) were included in this analysis. Participants were divided into four groups according to CRP and HDL-C levels on admission...
July 11, 2018: Current Neurovascular Research
https://www.readbyqxmd.com/read/29943702/prognostic-value-of-white-blood-cell-in-acute-ischemic-stroke-patients
#13
Xiaowei Zheng, Nimei Zeng, Aili Wang, Zhengbao Zhu, Chongke Zhong, Tan Xu, Tian Xu, Yanbo Peng, Hao Peng, Qunwei Li, Zhong Ju, Deqin Geng, Yonghong Zhang, Jiang He
BACKGROUND AND AIMS: It is unclear whether white blood cell on admission has a prognosis value on ischemic stroke and whether its function is affected by other inflammation factor. We hypothesized that elevated white blood cell is associated with stroke severity and 3-month mortality after acute ischemic stroke. METHODS: A total of 3891 acute ischemic stroke subjects from the China Antihypertensive Trial in Acute Ischemic Stroke (CATIS) were included in this analysis...
June 26, 2018: Current Neurovascular Research
https://www.readbyqxmd.com/read/29886830/statins-therapy-is-associated-with-increased-populations-of-early-endothelial-progenitor-cd133-vegfr2-and-endothelial-cd34-cd133-vegfr2-cells-in-patients-with-acute-ischemic-stroke
#14
Monika Golab-Janowska, Edyta Paczkowska, Boguslaw Machalinski, Agnieszka Meller, Dariusz Kotlega, Krzysztof Safranow, Pawel Wankowicz, Przemyslaw Nowacki
BACKGROUND: Endothelial progenitor cells (EPCs) have been suggested to be a therapeutic option in acute ischemic stroke (AIS). Statins modulate endothelial function and preserve blood flow to tissue exposed to an ischemic insult. We tested the hypothesis that statins therapy might augment circulating EPCs in patients with AIS. METHODS: Demographic data, classical vascular risk factors, treatment and National Institutes of Health Stroke Scale data were prospectively collected from 43 consecutive AIS patients (group I), comprising - 30 treated with statins ( group Statin(+)) and 13 untreated (group Statin (-))...
June 11, 2018: Current Neurovascular Research
https://www.readbyqxmd.com/read/29875001/safety-and-efficiency-of-low-dose-intra-arterial-tirofiban-in-mechanical-thrombectomy-during-acute-ischemic-stroke
#15
Tongya Yu, Yingying Lin, Aiping Jin, Pei Zhang, Xiaoyu Zhou, Min Fang, Xueyuan Liu
OBJECTIVE: In this study, we aimed to evaluate the safety and efficiency of low dose intra-arterial tirofiban in mechanical thrombectomy of acute ischemic stroke patients to facilitate the reperfusion of distal vessel. METHODS: We retrospectively analyzed 54 consecutive acute ischemic patients who underwent mechanical thrombectomy for large-vessel occlusion. Patients were divided into two groups based on whether intra-arterial tirofiban was used during mechanical thrombectomy to facilitate the reperfusion of distal vessel...
June 4, 2018: Current Neurovascular Research
https://www.readbyqxmd.com/read/29852869/microrna-155-regulates-inflammatory-response-in-ischemic-cerebral-tissues-through-autophagy
#16
Yi Yang, Ning Zhang, Shan Wang, Ya Wen
Our previous work has indicated that miR-155 expression induces inflammatory responses in ischemic cerebral tissues. However, the delicate regulation of miR-155-modifed inflammatory responses has remained enigmatic. In the present study, we found that autophagy is induced by ischemia through miR-155 and involved in neural injury.Subsequently, miR-155-induced autophagy modifies inflammatory responses through regulating TLR4/NF-κB pathway in ischemic cerebral tissues. Thus, miR-155 elevated autophagy is detrimental for ischemic cerebral injury and miR-155-induced autophagy modulates inflammatory responses through activating TLR4/NF-κB pathway...
May 31, 2018: Current Neurovascular Research
https://www.readbyqxmd.com/read/29807514/intracranial-fluid-dynamics-changes-in-idiopathic-intracranial-hypertension-pre-and-post-therapy
#17
Nivedita Agarwal, Christian Contarino, Nicola Limbucci, Laura Bertazzi, Eleuterio Toro
OBJECTIVE: Idiopathic intracranial hypertension (IIH) is a condition of unknown etiology frequently associated with dural sinus stenosis. There is emerging evidence that venous sinus stenting is an effective treatment. We use phase contrast cine MRI to observe changes in flow dynamics of multiple intracranial fluids and their response to different treatments in a patient with IIH. METHODS: we quantified the following parameters at the level of the aqueduct of Sylvius and the cervical C2C3: cerebrospinal fluid (CSF), arterial and venous flow; CSF velocity amplitude; artero-venous delay (AVD); artero-CSF delay and percentage of venous outflow normalized to total arterial inflow (tIJV/tA)...
May 27, 2018: Current Neurovascular Research
https://www.readbyqxmd.com/read/29804533/bradykinin-b2-receptors-play-a-neuroprotective-role-in-hypoxia-reoxygenation-injury-related-to-pyroptosis-pathway
#18
Min Tang, Xia Li, Ping Liu, Jianwen Wang, Fangping He, Xiongchao Zhu
BACKGROUND: Kinins are pro-inflammatory peptides that mediate numerous vascular and pain responses in tissue injury. Kinins exert their biological functions via two G-protein-coupled receptors: bradykinin 1 receptor (B1R) and bradykinin 2 receptor (B2R). We previously demonstrated the up-regulation of B2R after hypoxia/reoxygenation (H/R) injury in primary cultured cortical neurons. However, the role of B2R in inflammasome-induced pyroptosis remains unknown. METHODS: We induced H/R neuronal injury in primary cultured cortical neurons harvested from embryonic day 17 brains...
May 27, 2018: Current Neurovascular Research
https://www.readbyqxmd.com/read/29804532/onjisaponin-b-ob-is-neuroprotective-during-cognitive-loss-through-immune-mediated-and-sirt1-pathways
#19
Xinyu Li, Jingxin Li, Yafen Wei, Lihong Zhou, Ping Yin, Yongdan Liu, Shanshan Wu, Li Liu, Chong Lu
BACKGROUND--The purpose of the present study was to investigate the effects of onjisaponin B (OB) in lipopolysaccharide (LPS)-induced cognitive deficits. METHODS--The rats were divided into four groups: sham group, LPS group (the model group), LPS + OB (1 mg/kg) group, LPS + OB (2 mg/kg) group. OB were treated three days before surgery and thereafter continuously for 7 days. Three days later, rats were intracerebroventricularly injected with LPS. The levels of inflammatory cytokines, and the capability of free radial scavenging in serum and hippocampus were determined after the LPS challenge...
May 27, 2018: Current Neurovascular Research
https://www.readbyqxmd.com/read/29766805/a-novel-neuroimaging-model-to-predict-early-neurological-deterioration-after-acute-ischemic-stroke
#20
Yen-Chu Huang, Yuan-Hsiung Tsai, Jiann-Der Lee, Jen-Tsung Yang, Yi-Ting Pan
OBJECTIVE: In acute ischemic stroke, early neurological deterioration (END) may occur in up to one-third of patients. However, there is still no satisfying or comprehensive predictive model for all the stroke subtypes. We propose a practical model to predict END using magnetic resonance imaging (MRI). METHOD: Patients with anterior circulation infarct were recruited and they underwent an MRI within 24 hours of stroke onset. END was defined as an elevation of ≥2 points on the National Institute of Health Stroke Scale (NIHSS) within 72 hours of stroke onset...
May 16, 2018: Current Neurovascular Research
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