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Experimental and Clinical Transplantation

Dávid Á Kovács, Andries E Braat, Volkert A L Huurman, Andrzej G Baranski
Simultaneous pancreas-kidney transplant is the ultimate therapy for patients who have uncontrolled and complicated type 1 diabetes mellitus with end-stage renal disease. The combined pancreas transplant provides a euglycemic milieu for the kidney and protects it from recurrence of diabetic complications. Our patient, a 41-year-old woman with end-stage diabetic nephropathy and history of multiple abdominal surgeries (ovarian cyst fenestration, adnexal extirpation, abdominal wall reconstruction), including urinary diversion (Bricker loop, above double J stent), underwent simultaneous pancreas-kidney transplant...
November 6, 2018: Experimental and Clinical Transplantation
Kemal Murat Haberal, Feride Kural Rahatlı, Hale Turnaoğlu, Gonca Özgün, Mehmet Coşkun
OBJECTIVES: Computed tomography liver volumetry has been widely used to detect total and segmental liver volume in living-donor liver transplantation. However, use of this technique to evaluate the cirrhotic liver remains unclear. In this study, we evaluated the accuracy of freehand computed tomography volumetry to assess total liver volume by comparing weights of total hepatectomy specimens in patients with cirrhosis. For our analyses, we considered the density of a cirrhotic liver to be 1...
November 6, 2018: Experimental and Clinical Transplantation
Manon Allaire, Olivier Sérée, Audrey Coilly, Pauline Houssel-Debry, Martine Neau-Cransac, Georges-Philippe Pageaux, Jérôme Dumortier, Mario Altieri
No abstract text is available yet for this article.
November 6, 2018: Experimental and Clinical Transplantation
Feride Kural Rahatli, Hale Turnaoglu, Kemal Murat Haberal, Mahir Kirnap, Cihan Fidan, Cihat Burak Sayın, Nihal Uslu, Mehmet Haberal
OBJECTIVES: The Achilles tendon, which is composed of tendinous parts of gastrocnemius and soleus muscles, is the strongest and the largest tendon in the human body. Chronic renal disease can lead to reduced physical activity and exercise capacity. Spontaneous rupture of the Achilles tendon can occur in patients with chronic renal failure, with recurrent microtraumas, hypoxia, and chronic acidosis as predisposing factors. Here, we assessed and compared the elastographic findings in the Achilles tendon using acoustic radiation force impulse elastography in patients on chronic hemodialysis, in renal transplant patients, and in healthy volunteers...
November 6, 2018: Experimental and Clinical Transplantation
Cemalettin Koc, Sami Akbulut, Sezai Yilmaz
OBJECTIVES: This study aimed to compare the impact of deceased-donor organ procurement techniques (standard versus modified standard) on biochemical outcomes after liver transplant. MATERIALS AND METHODS: From February 2006 to December 2013, organs were recovered from 105 consecutive deceased donors by our transplant team. All organ procurement procedures were performed by a pioneer surgeon experienced in organ recovery from deceased donors. Donors were divided into those who had the abdominothoracic approach, which is referred to as the standard technique, and those who had the abdominal approach, which is referred to as the modified standard technique...
November 6, 2018: Experimental and Clinical Transplantation
Damir Pelicic, Batric Vukcevic, Darijo Bokan, Vesna Stojanovic, Nemanja Radojevic
OBJECTIVES: The aim of this research was to determine the attitudes of transplant-related health care workers and the local population of Montenegro toward organ donation and transplantation. MATERIALS AND METHODS: Our study included 200 transplant-related health care professionals (from the Clinical Center of Montenegro, the only transplant hospital in the country) and 200 volunteers from Podgorica (the capital of Montenegro). Their attitudes were evaluated using an anonymous, self-administered, multiple-choice questionnaire...
November 6, 2018: Experimental and Clinical Transplantation
Iratxe López-Pelayo, María Auxiliadora Mazuecos Blanca, María Victoria García Palacios, Fátima Galán Sánchez, Francisca López Rodríguez, María Angeles Bailén García
OBJECTIVES: Management of renal transplant recipients involves measuring glomerular filtration rate and albuminuria; however, data are conflicting on the use of estimating equations or creatinine clearance and albumin-creatinine ratio in early morning urine or albumin excretion in 24-hour urine. We aimed to determine the performance of creatinine clearance and 3 estimated creatinine-based formulas and compare the usefulness of albumin-creatinine ratio related to albumin excretion in kidney transplant patients...
October 24, 2018: Experimental and Clinical Transplantation
Dushyanth Srinivasan, John T Stoffel, Kori Bradley, Randall S Sung
OBJECTIVES: Long-term outcomes of kidney transplant recipients with postoperative genitourinary tract infections are not well characterized. In this single center retrospective study, we aimed to investigate the long-term effects of early posttransplant genitourinary infections under a protocol that included 1 month of antibiotic prophylaxis on graft failure and patient outcomes. MATERIALS AND METHODS: Electronic medical records of 1752 recipients of kidney-alone transplant between January 2000 and December 2008 were reviewed...
October 24, 2018: Experimental and Clinical Transplantation
Damiano Patrono, Silvia Marola, Ezio David, Luigi Chiusa, Silvia Martini, Stefano Mirabella, Francesco Lupo, Mauro Salizzoni, Renato Romagnoli
OBJECTIVES: Veno-occlusive disease after liver transplant has been sporadically reported, and significant uncertainty exists concerning the best treatment and the long-term outcomes. Here, we reviewed our experience to evaluate clinical presentation, treatment, and the long-term outcomes of these patients. MATERIALS AND METHODS: Between 2000 and 2015, 2165 patients underwent liver transplant at our center. The incidence of veno-occlusive disease was 0.3% (7/2165)...
October 24, 2018: Experimental and Clinical Transplantation
Emir Karaçağlar, Arzu Neslihan Akgün, Cüneyt Aytekin, Alp Aydınalp, Atilla Sezgin, I Haldun Müderrisoğlu
Spontaneous atraumatic axillary artery bleeding is an unusual clinical entity. Axillary artery bleeding is associated with a high mortality rate. Vascular fragility is defined as a decrease in blood vessel resistance, and increased vascular fragility is one of the reasons for arterial bleeding. In this report, we present a case of spontaneous axillary artery bleeding in a heart transplant recipient.
October 24, 2018: Experimental and Clinical Transplantation
Yu-Cheng Chiu, Meng-Hsing Ho, Teng-Wei Chen, Chung-Bao Hsieh, Hsiu-Lung Fan
Drug-drug interactions between azoles and calcineurin inhibitors can cause issues for organ transplant specialists. Clinical practice guidelines for the treatment of solid-organ transplant recipients with invasive aspergillosis infection are lacking. Here, we present a patient who developed pulmonary aspergillosis after liver transplant. The patient had prolonged treatment with echinocandin that was not effective. A drug-drug interaction between azoles and tacrolimus caused issues for the clinical physician...
October 24, 2018: Experimental and Clinical Transplantation
Seong Hyuk Park, Seok-Chan Eun
The evolution and success of intestinal and multi-visceral transplantation over the past 20 years have raised the issue of difficult or even impossible abdominal closure, a topic rarely encountered in other fields of transplantation. Different techniques have been proposed to address this topic. The choice depends on the transplant team's expertise and/or the availability of a plastic surgery service. Abdominal wall transplant is a type of composite tissue allograft that can be utilized to reconstitute the abdominal domains of patients who undergo intestinal transplant, and the results are encouraging...
October 24, 2018: Experimental and Clinical Transplantation
Sophia Lionaki, Apostolos Pappas, Nikolaos Altanis, Helen Kapsia, George Liapis, Angeliki Vittoraki, Alice Iniotaki, George Zavos, John N Boletis
OBJECTIVES: In this study, we explored the effect of the primary disease nature on development of de novo donor-specific antibodies after kidney transplant. MATERIALS AND METHODS: We retrospectively studied kidney transplant recipients based on their primary disease. Patients were divided according to autoimmune and nonautoimmune diseases. The frequency of de novo donor-specific antibodies posttransplant and the incidence of acute rejection were estimated. De novo donor-specific antibodies were determined by the Luminex (LAB Screen products, One Lambda, Inc...
October 24, 2018: Experimental and Clinical Transplantation
Arun Gupta, Gaurav Gangwani, Naimish Mehta, Nishant Wadhwa, Samarjit Ghuman, Ajit Yadav
In patients with complete portal vein thrombosis, the main portal vein is obstructed, resulting in development of hepatopetal collateral vessels. In cases of complete portal vein thrombosis, interventional procedures are challenging, with the greatest difficulty in the form of passing the guide wire across the level of obstruction. A recognizable main portal vein remnant has been deemed as a mandatory criterion in previous reports. Here, we report a case of cavernous trans-formation of the portal vein in a pediatric patient after liver transplant who had no obvious detectable portal vein remnant on radiologic imaging...
October 19, 2018: Experimental and Clinical Transplantation
Morgane Villemaire, Thomas Jouve, Anne Bourdin, Bénédicte Janbon, Nicole Pinel, Rachel Tetaz, Nicolas Terrier, Lionel Rostaing, Dominique Masson, Paolo Malvezzi
OBJECTIVES: Chronic antibody-mediated rejection is the main cause of late kidney graft loss. The presence of donor-specific antibodies in the serum is the main criterion for this diagnosis. Single antigen Luminex assays can identify donor-specific antibodies, and semiquantitative estimates of antibodies can be assessed using mean fluorescence intensity. Recent data have shown that patients whose donor-specific antibodies fix C3d have worse clinical outcomes, implying that C3d-specific Luminex assays may provide useful prognostic data...
October 19, 2018: Experimental and Clinical Transplantation
Altan Alim, Yalcin Erdogan, Murat Dayangac, Yildiray Yuzer, Yaman Tokat, Arzu Oezcelik
OBJECTIVES: Early hepatic artery thrombosis is rare but devastating in living-donor liver transplant recipients. In this study, our aim was to evaluate the results of all patients with early hepatic artery thrombosis at our center. MATERIALS AND METHODS: Between October 2004 and November 2015, 841 patients underwent liver transplant for end-stage liver disease at our center. All recipients with early hepatic artery thrombosis were identified and retrospectively analyzed...
October 19, 2018: Experimental and Clinical Transplantation
Hanan El Baz, Zeinab Demerdash, Manal Kamel, Shimaa Atta, Faten Salah, Salwa Hassan, Olfat Hammam, Heba Khalil, Ali Bayoumi
OBJECTIVES: Liver transplantation is the well-known treatment for chronic liver diseases; however, postoperative complications and lack of donors continue to be limitations with this treatment. Investigating new modalities for treatment of chronic liver illness is a must. In the present study, we aimed to clarify the effects of an in vitro hepatocyte-differentiated human unrestricted somatic stem cell transplant as a new cell-based therapy in an experimental model of chronic liver failure...
October 19, 2018: Experimental and Clinical Transplantation
Luca Bortolasi, Paola Violi, Amedeo Carraro, Umberto Montin, Angelo Cerofolini, Andrea Munari, Albino Eccher, Roberto Gramignoli, Chiara Bovo, Umberto Tedeschi
OBJECTIVES: Liver transplant represents the criterion standard therapy for end-stage liver disease. Biliary complications after liver transplant have shown an increased trend and are characterized by anastomotic and nonanastomotic stenoses. MATERIALS AND METHODS: This retrospective single-center observational study included 217 patients who underwent liver transplant between January 2004 and December 2014; 18 patients had anastomotic (8.3%) and 29 (13.4%) had non-anastomotic stenoses...
October 19, 2018: Experimental and Clinical Transplantation
Helin Sahinturk, Aycan Ozdemirkan, Olcay Yilmaz, Pinar Zeyneloglu, Adnan Torgay, Arash Pirat, Mehmet Haberal
OBJECTIVES: We examined whether immediate tracheal extubation among pediatric liver transplant recipients was safe and feasible. MATERIALS AND METHODS: We retrospectively analyzed medical records of pediatric liver transplant recipients at Baskent University Hospital from January 2012 to December 2017. We grouped children who were extubated in the operating room versus those extubated in the intensive care unit. RESULTS: In our study group of 81 pediatric patients, median age was 4 years (range, 4 mo to 16 y) and 44 (54%) were male...
October 19, 2018: Experimental and Clinical Transplantation
Ramin Yaghobi, Mohammad Javad Kazemi, Bita Geramizadeh, Seyed Ali Malek Hosseini, Javad Moayedi
OBJECTIVES: Investigations into the viral causes of end-stage liver disease in liver transplant patients with cryptogenic underlying disease remain of interest. Hepatitis C virus infection, especially in its silent (occult) form, may play a key role in the introduction and development of cryptogenic cirrhosis. We aimed to determine the prevalence of occult hepatitis C virus infection in liver transplant recipients with cryptogenic cirrhosis. MATERIALS AND METHODS: In this cross-sectional study, 127 liver transplant recipients confirmed to have cryptogenic cirrhosis were included...
October 19, 2018: Experimental and Clinical Transplantation
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