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Experimental and Clinical Transplantation

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https://www.readbyqxmd.com/read/28031007/polymorphisms-of-the-costimulatory-genes-ctla-4-cd28-pd-1-and-icos-and-outcome-of-kidney-transplants-in-iranian-patients
#1
Ahmad Niknam, Mohammad Hossein Karimi, Bita Geramizadeh, Jamshid Roozbeh, Ramin Yaghobi, Mehdi Salehipour
OBJECTIVES: Costimulatory molecules are important factors determining the outcome of transplant. The aim of the present study was to investigate the effect of CTLA-4, CD28, PD-1, and ICOS gene polymorphisms on the outcome of kidney transplant. MATERIALS AND METHODS: A total of 172 kidney transplant recipients were included in this study. There were 45 recipients (26%) who experienced acute rejection. The CTLA-4, PD-1, ICOS, and CD28 gene polymorphisms were evaluated by polymerase chain reaction and restriction fragment length polymorphism methods...
December 27, 2016: Experimental and Clinical Transplantation
https://www.readbyqxmd.com/read/28005001/recurrent-urinary-tract-infection-among-renal-transplant-recipients-risk-factors-and-long-term-outcome
#2
Khaled Abdel Tawab, Osama Gheith, Torki Al Otaibi, Naryanam Nampoory, Hany Mansour, Medhat A Halim, Prasad Nair, Tarek Said, Mohamed Abdelmonem, Ayman El-Sayed, Waleed Awadain
OBJECTIVES: Urinary tract infection is the most common type of bacterial infection in kidney transplant procedures, with adverse effects on graft and patient survival. We aimed to evaluate the risk factors of recurrent urinary tract infection in renal transplant recipients and its impact on patient and graft survival. MATERIALS AND METHODS: In a cohort of 1019 patients who were transplanted between 2000 and 2010 at Hamed Al-Essa Organ Transplant Center in Kuwait, 86% developed at least 1 episode of urinary tract infection, with only 6...
December 22, 2016: Experimental and Clinical Transplantation
https://www.readbyqxmd.com/read/28005000/nonsurgically-treated-sigmoid-volvulus-in-a-young-patient-3-days-after-renal-transplant
#3
İsmail Bilgiç, Mehmet Tolga Kafadar, Işılay Nadir, Mukaddes Ayşe Bilgiç, Ali Akçay, Aydın Dalgıç
Sigmoid volvulus is a rare clinical condition in young individuals. It should be accurately diagnosed and treated in a rapid manner. Surgical and nonsurgical conservative methods are used for the treatment of sigmoid volvulus. Patients having no signs of perforation or peritonitis should be primarily treated by colonoscopic detorsion. A delay in the diagnosis and treatment of this condition may cause significant morbidity and mortality in an immunosuppressed patient with newly performed renal transplant and diffuse abdominal pain...
December 22, 2016: Experimental and Clinical Transplantation
https://www.readbyqxmd.com/read/28004999/a-follow-up-study-on-the-renal-protective-efficacy-of-telbivudine-for-hepatitis-b-virus-infected-taiwanese-patients-after-living-donor-liver-transplant
#4
Kuo-Hua Lin, Yao-Li Chen, Ping-Yi Lin, Chia-En Hsieh, Chih-Jan Ko, Chia-Cheng Lin, Ying-Zi Ming
OBJECTIVES: Preservation of renal function is an important issue after living donor liver transplant. We aimed to examine the renal protective efficacy of telbivudine in hepatitis B virus-infected patients after living donor liver transplant. MATERIALS AND METHODS: In this retrospective study, we compared 18 patients who received telbivudine 600 mg once per day and 23 patients who received entecavir 1 mg once per day after living donor liver transplant. Clinical data were obtained through chart review and included Model for End-Stage Liver Disease score and pre- and postoperative aspartate aminotransferase, alanine aminotransferase, and creatinine levels and estimated glomerular filtration rate...
December 22, 2016: Experimental and Clinical Transplantation
https://www.readbyqxmd.com/read/28004998/de-novo-vascular-lesions-after-liver-transplant-in-a-case-with-hereditary-hemorrhagic-telangiectasia-and-fibropolycystic-liver-disease-long-term-follow-up-with-magnetic-resonance-imaging-and-magnetic-resonance-angiography
#5
Sila Ulus, Aydan Arslan, Ercan Karaarslan, Yilmaz Cakaloglu
We report a case of a 62-year-old woman who received a liver transplant 19 years previously for end-stage liver disease due to hereditary hemorrhagic telangiectasia and fibropolycystic liver disease. During long-term follow-up 8 years after the liver transplant, de novo vascular lesions were detected with magnetic resonance imaging and magnetic resonance angiography. Hepatic vascular lesions had slowly progressed, despite no symptoms. To our knowledge, there are few reports in the English literature of de novo vascular lesions after liver transplant in patients with hepatic telangiectasias...
December 22, 2016: Experimental and Clinical Transplantation
https://www.readbyqxmd.com/read/28004997/effect-of-long-term-low-dose-aspirin-therapy-on-renal-graft-function
#6
Hatem Ali, Ahmed Shaaban, Asam Murtaza, Laura E Howell, Aimun Ahmed
OBJECTIVES: Despite improvements in immunosuppressive protocols for renal transplant, long-term success of renal transplant is still limited by the occurrence of interstitial fibrosis and tubular atrophy. Some studies have shown that aspirin decreases the severity of kidney ischemia-reperfusion injury and the development of tubular atrophy in animal models. This study aimed to assess the effects of aspirin therapy started at the time of transplant on long-term graft function. MATERIALS AND METHODS: We compared renal graft function of 82 patients on low-dose aspirin 75 mg once daily who underwent renal transplant between 1 January 2000 and 31 December 2010 from a single center with 65 patients not taking aspirin...
December 22, 2016: Experimental and Clinical Transplantation
https://www.readbyqxmd.com/read/28004996/splenic-subcapsular-hematoma-after-endoscopic-retrograde-cholangiopancreatography-in-a-liver-transplant-recipient-case-report-and-literature-review
#7
Martin Montenovo, Emran Javed, Ramasamy Bakthavatsalam, Jorge Reyes
Splenic injuries after an endoscopic retrograde cholangiopancreatography are a rare but lethal complication. We describe a subcapsular splenic hematoma requiring emergent splenectomy after an endoscopic retrograde cholangiopancreatography in a liver transplant recipient.
December 22, 2016: Experimental and Clinical Transplantation
https://www.readbyqxmd.com/read/27938318/incisional-infections-after-renal-transplant-outcome-data-from-238-consecutive-recipients
#8
Demetrios Moris, Spyridon Davakis, Kiriaki Kakavia, John Bokos, Spyridon Vernadakis, Konstantinos Diles, Georgios Sotirchos, Alexandros Barlas, Mina Psychogiou, Georgios Zavos
OBJECTIVES: Surgical incision infections, along with urinary tract infections, are among the most common infective complications after kidney transplant. The aim of this retrospective study is to evaluate the incidence and predisposing factors of surgical incision infection development in renal transplant recipients. MATERIALS AND METHODS: Between 1 January 2012 and 31 December 2015, there were 238 consecutive kidney transplant procedures performed in our unit. Of these, 146 patients received deceased donor kidney allografts and 92 had transplants from living related donors...
December 12, 2016: Experimental and Clinical Transplantation
https://www.readbyqxmd.com/read/27938317/cell-viability-of-human-embryonic-stem-cells-stored-for-a-period-of-9-years
#9
Geeta Shroff, Damini Vatsa
OBJECTIVES: Human embryonic stem cells are pluripotent cell lines usually derived from human blastocysts. Their potential critically depends on long-term proliferative capacity, developmental potential after prolonged culture, and karyotypic stability. Cell viability is an important parameter for assessing cell sample quality. Here, we elaborate the stored human embryonic stem cell lines' viability in a ready to use form for a period of 9 years (from 2007 to 2015). MATERIALS AND METHODS: Spare pre implantation stage in vitro fertilized ovum-derived cell lines were cultured in suitable media...
December 12, 2016: Experimental and Clinical Transplantation
https://www.readbyqxmd.com/read/27938316/two-decades-of-tacrolimus-in-renal-transplant-basic-science-and-clinical-evidences
#10
Badri Man Shrestha
Tacrolimus, a calcineurin inhibitor, has been the cornerstone of immunosuppressive regimens in renal transplant over 2 decades. This has significantly improved the outcomes of renal transplant, including reduction of acute rejection episodes, improvement of renal function and graft survival, and reduction of some of the adverse effects associated with cyclosporine. However, use of tacrolimus is associated with a number of undesirable effects, such as nephrotoxicity, post?ransplant diabetes mellitus, neurotoxicity, and cosmetic and electrolyte disturbances...
December 12, 2016: Experimental and Clinical Transplantation
https://www.readbyqxmd.com/read/27938315/epilepsy-after-heart-transplant-a-single-center-experience
#11
Ruhsen Öcal, Taner Sezer, Seda Kibaroğlu, Eda Derle, Sibel Benli, Atilla Sezgin, Sait Aşlamacı
OBJECTIVES: Cardiac transplant is the best treatment for patients with end-stage heart failure. Neurologic complications occur at a rate of 30% to 80% in patients undergoing cardiac transplant. Seizures occur at a rate of 2% to 20%. The main causative factors include immunosuppressant drug toxicity, infections, brain lesions, and metabolic disorders. Here, our aim was to determine seizure types and associated conditions in patients undergoing cardiac transplant and to report our treatment experience at our institution...
December 12, 2016: Experimental and Clinical Transplantation
https://www.readbyqxmd.com/read/27938314/sequential-onset-of-varicella-zoster-virus-encephalomeningitis-and-progressive-multifocal-leukoencephalopathy-in-an-allogeneic-hematopoietic-stem-cell-transplant-recipient
#12
Yukiko Yamashita, Shinsuke Kusakabe, Jun Toda, Kenji Ohshima, Hiroaki Masaie, Toshinari Yagi, Hitoshi Yoshida, Jun Ishikawa
Here, we describe a case of sequential varicella-zoster virus encephalomeningitis and progressive multifocal leukoencephalopathy following an allogeneic hematopoietic stem cell transplant procedure. A 37-year-old male patient presented with fever, incomplete paralysis of bilateral legs, and bullous eruptions 8 months after allogeneic transplant. Polymerase chain reaction assays of cerebrospinal fluid samples for varicella-zoster virus were positive. Bullous eruptions and incomplete paralysis of bilateral legs improved after administration of acyclovir...
December 12, 2016: Experimental and Clinical Transplantation
https://www.readbyqxmd.com/read/27915968/peripheral-t-cell-lymphoma-a-posttransplant-lymphoproliferative-disorder-presenting-as-a-jejunal-mass-in-a-renal-transplant-recipient
#13
Aanchal Kakkar, Immanuel Pradeep, Geetika Singh, Amit Dinda, Sanjay K Agarwal
Posttransplant lymphoproliferative disorders are a spectrum of lymphoproliferative disorders seen in recipients of solid-organ, bone marrow, and stem cell allografts. They include polyclonal early lesions mimicking infectious mononucleosis and monoclonal proliferations of B and T cells, indistinguishable from lymphomas occurring in immunocompetent individuals. Although most posttransplant lymphoproliferative disorders are B-cell neoplasms, T-cell posttransplant lymphoproliferative disorders are very rare. Among solid-organ transplants, renal allografts have low risk for development of posttransplant lymphoproliferative disorders...
December 2, 2016: Experimental and Clinical Transplantation
https://www.readbyqxmd.com/read/27915967/liver-transplant-can-resolve-severe-neuropsychiatric-manifestations-of-wilson-disease-a-case-report
#14
Gregory Walker, Trana Hussaini, Robert Stowe, Silke Cresswell, Eric M Yoshida
Although liver transplant for decompensated cirrhosis secondary to Wilson disease is well accepted, the use of transplant for patients with severe neurologic manifestations of this condition remains controversial, and these can be perceived as a contraindication. Here, we describe a 45-year-old woman who presented with an incidental hepatocellular carcinoma at the time of transplant. The patient had severe neurologic manifestations of Wilson disease pretransplant, including dysarthria, hyperreflexia, asymmetrical ataxia, tremor, bradyphrenia, and shuffling gait...
December 2, 2016: Experimental and Clinical Transplantation
https://www.readbyqxmd.com/read/27915966/hepatitis-c-virus-in-the-renal-transplant-population-an-update-with-focus-on-the-new-era-of-antiviral-regimens
#15
Osama Gheith, Medhat A Halim, Nashwa Othman, Torki Al-Otaibi, Prasad Nair, Naryanan Nampoory
Chronic hepatitis C virus infection is a global health problem, especially among renal transplant recipients. Herein, we present an overview of hepatitis C virus among renal transplant patients, with a focus on some updated aspects concerning types of viral genotypes, methods of diagnosis, the effects of renal transplant on hepatitis C virus infection, and summary of hepatitis C virus-related complications after renal transplant. We also discuss patient and graft survival rates and the present and future therapeutic options with special focus on new antiviral and possible interactions with immunosuppressive medications...
December 2, 2016: Experimental and Clinical Transplantation
https://www.readbyqxmd.com/read/27915965/systematic-review-on-role-of-mammalian-target-of-rapamycin-inhibitors-as-an-alternative-to-calcineurin-inhibitors-in-renal-transplant-challenges-and-window-to-excel
#16
Jayant Kumar, Julie M Bridson, Ajay Sharma, Ahmed Halawa
OBJECTIVES: This review focuses on the current limited evidence of graft function and graft survival in various immunosuppressive regimens involving mammalian target of rapamycin inhibitors with or without calcineurin inhibitors. MATERIALS AND METHODS: We evaluated the current literature for describing the role of mammalian target of rapamycin inhibitors as an alternative to calcineurin inhibitors by searching the PubMed, EMBASE, Cochrane, Crossref, and Scopus databases using medical subject heading terms...
December 2, 2016: Experimental and Clinical Transplantation
https://www.readbyqxmd.com/read/27915964/posttransplant-de-novo-hepatitis-c-virus-infection-in-renal-transplant-recipients-its-impact-on-morbidity-and-mortality
#17
Farina M Hanif, S Muddasir Laeeq, Nasir Hassan Luck, Tahir Aziz, Zaigham Abbas, Muhammed Mubarak
OBJECTIVES: The clinical effects of hepatitis C virus infection acquired after transplant have not been thoroughly studied. We aimed to study hepatitis C virus-related morbidity and mortality with de novo hepatitis C virus infection after renal transplant. MATERIALS AND METHODS: Data from mortality files were retrospectively collected from January 2011 to January 2015. Patients were divided into 2 groups: hepatitis C virus positive (group A) and hepatitis C virus negative (group B)...
December 2, 2016: Experimental and Clinical Transplantation
https://www.readbyqxmd.com/read/27915962/generalized-pustular-psoriasis-von-zumbusch-type-following-renal-transplant-a-case-report
#18
Georgia Dedemadi, Maria Koukoulaki, Vassileios Vougas, Constantinos Noutsis, Aikaterini Pantelidaki, Spiros Drakopoulos
Generalized pustular psoriasis appears as an uncommon variant form of psoriasis consisting of widespread pustules on an erythematous background (von Zumbusch). A 39-year-old male patient with a history of plaque psoriasis since the age of 9 who had an acute relapse of generalized pustular psoriasis 12 days following a successful renal transplantation is presented. Despite administered immunosuppression for transplantation, the addition of cyclosporine and methotrexate did not reverse the ongoing process of disease and the patient died on the 57th posttransplant day due to multiorgan failure subsequent to severe bone marrow suppression...
December 2, 2016: Experimental and Clinical Transplantation
https://www.readbyqxmd.com/read/27915961/immediate-vascular-complications-after-kidney-transplant-experience-from-2100-recipients
#19
Mahmoud Tavakkoli, Reza Mahdavi Zafarghandi, Rahim Taghavi, Alireza Ghoreifi, Masoud Mahdavi Zafarghandi
OBJECTIVES: Vascular complications, especially immediate events during kidney transplant, are the major cause of graft loss, and prompt surgical intervention is important for salvage of the graft and recipient. In this study, our aim was to show our experiences with vascular interventions and their effects on graft outcomes in transplant patients with suspected immediate vascular events. MATERIALS AND METHODS: Over 24 years (from 1990 to 2014), 2100 renal transplant procedures (1562 living and 538 deceased donors) were performed by one fixed team...
December 2, 2016: Experimental and Clinical Transplantation
https://www.readbyqxmd.com/read/27855592/role-of-allogeneic-stem-cell-transplant-in-the-treatment-of-primary-myelofibrosis
#20
Nur Soyer, Ferit Celik, Murat Tombuloglu, Fahri Sahin, Guray Saydam, Filiz Vural
OBJECTIVES: The only known curative therapy for primary myelofibrosis is allogeneic hematopoietic stem cell transplant. MATERIALS AND METHODS: We retrospectively evaluated 11 transplant procedures involving 10 patients (5 men and 5 women) diagnosed with primary myelofibrosis between 2005 and 2014. RESULTS: The median age at the time of transplant was 60.5 years (range, 22-62 years). Stem cell sources were unrelated (n=1) and related (n=11) peripheral blood stem cells...
November 18, 2016: Experimental and Clinical Transplantation
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