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Experimental and Clinical Transplantation

Alireza Shamsaeefar, Taiser Saleh, Kourosh Kazemi, Saman Nikeghbalian, Masood Dehghani, Mohsen Mansurian, Siavash Gholam, Bahareh Khosravi, Seyyed Ali Malek Hosseini
OBJECTIVES: Liver transplant is the most effective treatment modality for patients with end-stage liver disease, metabolic disorders, hepatic malignancy, and acute liver failure. When a graft fails after primary liver transplant, retransplant of the liver remains the only option. Here, we report the past 12-year experience of the Shiraz Transplant Center regarding liver retransplant. MATERIALS AND METHODS: This is a retrospective cohort study of a 12-year period (2004-2015) of the Shiraz Center in Iran...
July 11, 2018: Experimental and Clinical Transplantation
Arash Soudmand, Funda Ulu Ozturk, Nihal Uslu, Nihan Haberal, Fatih Boyvat, Gokhan Moray, Mehmet Haberal
OBJECTIVES: Although biopsy is the most important method for diagnosing the cause of renal allograft dysfunction, sonoelastography, a new ultrasonography method, can be used to distinguish between the soft or hard nature of lesions. In this study, our aim was to investigate whether sonoelastography could diagnose fibrosis in renal transplant patients. MATERIALS AND METHODS: In this prospective study, we included patients over 18 years old who were recommended for clinical biopsy...
July 11, 2018: Experimental and Clinical Transplantation
Sertaç Usta, Koray Karabulut
Posterior reversible encephalopathy syndrome is a rare condition of the central nervous system that may occur in adults as well as in children. Clinically, it presents with mental status changes, visual loss, headaches, seizures, or coma. The diagnosis of posterior reversible encephalopathy syndrome is based on the typical appearance in occipital and parietal lobes in radiologic imaging studies, such as computed tomography or magnetic resonance imaging of the brain, which exhibit the typical appearance due to vasogenic edema...
July 11, 2018: Experimental and Clinical Transplantation
Tiffany I Hsiao, Joseph R Scalea
Few studies have described glucose metabolism in the immediate posttransplant period. Here, we report a 37-year-old female patient who had transient hypoglycemia after combined pancreas and kidney transplant for poorly controlled type 1 diabetes and renal failure. Although the patient's blood sugar decreased from 420 to less than 120 mg/dL and the kidney demonstrated graft function immediately posttransplant, at 19 hours after transplant, the patient's blood glucose decreased to below the normal range at a nadir of 59 mg/dL...
July 11, 2018: Experimental and Clinical Transplantation
Boju Sangeetha Lakshmi, Bhukya Vidya, Mogili Hari Krishna Reddy, Anil Cheni Venkata Kumar, Rapur Ram, Vishnubotla Siva Kumar
Early trials of tacrolimus in renal transplant recipients have not revealed hearing loss as an adverse effect. Here, we present a case report and a review of the literature of deafness after tacrolimus use. The review of the literature and our experience suggested that the possible reason for hearing loss could be due to an initiation of a sudden spike in the tacrolimus serum level, which was later worsened by its cumulative toxic effect.
July 2, 2018: Experimental and Clinical Transplantation
Pusem Patir, Nur Soyer, Isabel Raika Durusoy, Fahri Sahin, Guray Saydam, Mahmut Tobu, Murat Tombuloglu, Filiz Vural
OBJECTIVES: The aim of our study was to evaluate the efficacy and toxicity of TECAM (thiotepa, etoposide, cyclophosphamide, cytarabine, and melphalan) and BEAM (carmustine, etoposide, cytarabine, and melphalan) conditioning regimens before autologous hematopoietic stem cell transplant in patients with lymphoma. MATERIALS AND METHODS: We retrospectively analyzed 108 relapsed/refractory lymphoma patients who had high-dose treatments followed by autologous hematopoietic stem cell transplant between October 2012 and February 2017...
June 28, 2018: Experimental and Clinical Transplantation
Isabel Legaz, Elena Navarro Noguera, Jose Miguel Bolarín, Jose Antonio Campillo, Rosa Moya, Aurelio Luna, Manuel Miras, Alfredo Minguela, Maria Rocio Álvarez-López, Manuel Muro
OBJECTIVES: The aim of this study was to analyze alcoholic cirrhosis in women who were to undergo liver transplant, including their biochemical and clinical characteristics, main complications, survival rates, and main causes of death compared with men with alcoholic cirrhosis. MATERIALS AND METHODS: Our study included 400 patients with alcoholic cirrhosis, which we divided according to sex and viral infections. Biochemical parameters and the presence and degree of ascites and encephalopathy, liver function status, and liver rejection and survival rates were analyzed from 1 to 10 years and the main cause of death at 10 years...
June 28, 2018: Experimental and Clinical Transplantation
Sulmaz Kamalifar, Negar Azarpira, Ladan Sadeghi, Sadegh Ghorbani-Dalini, Seideh Masoomeh Nekoei, Mahdokht H Aghdaie, Elaheh Esfandiari, Mohamad Reza Azarpira
OBJECTIVES: Wharton jelly mesenchymal stem cells are good candidates for application in different aspects of regenerative medicine, and their long-time banking is important. In this study, the effects of trehalose, ascorbic acid, and Y-27632 on proliferation and survival rate of these cells after cryopreservation were investigated. MATERIALS AND METHODS: Mesenchymal stem cells were isolated from human umbilical cord Wharton jelly and frozen using a slow-rate cooling process...
June 28, 2018: Experimental and Clinical Transplantation
Ahmed Abdelfattah Denewar, Mohamed Hamed Abbas, Hussein Attiya Sheashaa, Ibrahim Abdelaal, Khaled El-Dahshan, Yasser Elsayed Matter, Ayman Fathi Refaie
OBJECTIVES: Liver disease is an important cause of morbidity and mortality among recipients of transplanted organs. In addition to the liver, hepatitis C virus infection has a significant prevalence among recipients of kidney transplant and is related to worse graft and recipient survival as the kidney is an important component of the hepatitis C virus clinical syndrome. MATERIALS AND METHODS: This retrospective single center study included 336 patients with end-stage renal disease who received a kidney transplant at the Mansoura Urology and Nephrology Center from January 1992 to December 1995...
June 28, 2018: Experimental and Clinical Transplantation
Maliha Azmi, Asma Nasim, Sunil Dodani, Syed Mudassir Laiq, Syed Haider Mehdi, Muhammed Mubarak
A 43-year-old male patient developed varicella virus (chickenpox) 4 months after receiving a liver transplant. Within 5 days of complete recovery, he presented with widespread cutaneous vesicular eruptions involving the face, back, abdomen, and upper extremities. Tzanck smear showed ground glass inclusions in the nuclei of multinucleated giant cells, suggestive of viral pathology. The patient was subsequently diagnosed with Kaposi varicelliform eruption, a rare dermatologic emergency. He was treated with high-dose intravenous acyclovir and fully recovered...
June 28, 2018: Experimental and Clinical Transplantation
Manjunath Jeevanna Kulkarni, Archana Shrinivas Bhat
An elderly male renal allograft recipient presented with thrombocytopenia. He had a kidney transplant for diabetic kidney disease and was on azathioprine and prednisolone. He had taken Cissus quadrangularis capsules for backache. A bone marrow aspiration to evaluate the cause of thrombocytopenia showed megakaryocyte hyperplasia, suggesting peripheral destruction. Repeat platelet counts after stopping Cissus quadrangularis showed normal levels.
June 28, 2018: Experimental and Clinical Transplantation
Saira Ajmal, Michael Keating, Mark Wilhelm
Cryptococcal infection has been documented in 2.8% of solid-organ transplant recipients, with the median time to disease onset being 21 months. Renal transplant recipients account for the majority of cases. Most patients present with central nervous system or disseminated disease, with only a minority having cutaneous manifestations. We present the case of a 47-year-old female renal transplant recipient who presented with refractory acute cellulitis 7 months after transplant. She had received thymoglobulin induction and was on a maintenance immunosuppressive regimen of tacrolimus, mycophenolic acid, and prednisone (5 mg/d)...
June 28, 2018: Experimental and Clinical Transplantation
Cemal Kemaloğlu, Salih Özçobanoğlu, Umut Köksel, Ozan Erbasan, İlhan Gölbaşı, Cengiz Türkay, Ömer Bayezid
Extracorporeal membrane oxygenation therapy is being used increasingly in different areas. It has become an indispensable assistant to clinicians for hypoxic pulmonary disorders, cardiogenic shock, resuscitation, and during cardiac surgery. In this case report, we describe a patient who is bridged to successful cardiac retransplant under extracorporeal membrane oxygenation therapy support after extracorporeal membrane oxygenation therapy-assisted cardiopulmonary resuscitation.
June 28, 2018: Experimental and Clinical Transplantation
Suleyman Ozkan Aksoy, Tarkan Unek, Ali İbrahim Sevinc, Baha Arslan, Haluk Sirin, Zekai Serhan Derici, Hulya Ellidokuz, Ozgul Sagol, Cihan Agalar, İbrahim Astarcıoglu
OBJECTIVES: Hepatic resection and liver transplant are regarded as 2 potentially curative treatments for hepatocellular carcinoma. Here, we compared both options in patients with hepatocellular carcinoma secondary to cirrhosis seen at a single center over 12 years. MATERIALS AND METHODS: We evaluated early complications and survival of patients with hepatocellular carcinoma treated with liver transplant (57 patients) or hepatic resection (36 patients) at our center between 1998 and 2010...
June 28, 2018: Experimental and Clinical Transplantation
Hojong Park, Sang Jun Park, Kyuhyuk Kyong, Hong Rae Cho
Organ shortage is the greatest challenge facing the field of organ transplantation in Korea. There are no reports of patients who have undergone endovascular aneurysm repair being considered as kidney donors. We successfully performed kidney transplant procedures in a 62-year-old man and a 57-year-old man using kidneys recovered from a 67-year-old female brain-dead donor who underwent endovascular aneurysm repair 6 months before organ retrieval. To the best of our knowledge, this is the first report of transplants performed with organs from a donor who previously underwent endovascular aneurysm repair...
June 28, 2018: Experimental and Clinical Transplantation
Mari Ohtaka, Takashi Kawahara, Daiji Takamoto, Taku Mochizuki, Hiroaki Ishida, Yusuke Hattori, Kazuhide Makiyama, Masahiro Yao, Jun-Ichi Teranishi, Hiroji Uemura
OBJECTIVES: Because of recent developments in immunosuppressive therapy, renal transplant outcomes have improved. Although reports on the association between immunosuppressive therapy and malignant disease are available, the results are controversial. The neutrophil-to-lymphocyte ratio has been reported as an easy tumor marker for predicting the prognoses of some solid tumors. In the present study, we examined changes in neutrophil-to-lymphocyte ratio after renal transplant and discussed cases in which malignant disease developed after renal transplant...
June 18, 2018: Experimental and Clinical Transplantation
Amr Badawy, Toshimi Kaido, Yoshizawa Atsushi, Shintaro Yagi, Koichiro Hata, Naoko Kamo, Ken Fukumitsu, Hideaki Okajima, Shinji Uemoto
Evans syndrome is an uncommon disease characterized by a combination of autoimmune hemolytic anemia and autoimmune thrombocytopenia concomitantly or sequentially with a positive direct Coombs test in the absence of any underlying known cause. Here, we present a case of an adult patient who underwent living-donor liver transplant that was preceded by bone marrow transplant 20 years earlier from the same HLA identical donor and who received a single-agent immunosuppressive therapy for only 2 months as prophylaxis against graft-versus-host disease...
June 18, 2018: Experimental and Clinical Transplantation
Jinwoong Lee, Yeonho You, Jung Soo Park, Jin Hong Min, Insool Yoo, Wonjoon Jeong, Yongchul Cho, Seung Ryu, Seungwhan Kim, Sung Uk Cho, Se Kwang Oh, Junwan Lee, Hong Joon Ahn, Sang Min Jung
Incidences of brain death due to nicotine overdose by e-cigarettes have been increasing. In such cases, liver donation has been not reported because of the secondary damage to the liver due to metabolism of large amounts of nicotine. However, kidneys have been considered acceptable for transplant. Here, we present a successful case of liver transplant from a brain-dead donor due to intentional nicotine ingestion who did not have extensive steatosis. To the best of our knowledge, this is the first report of such a case...
June 18, 2018: Experimental and Clinical Transplantation
Felix Dondorf, Frank Uteβ, René Fahrner, Philipp Felgendreff, Michael Ardelt, Hans-Michael Tautenhahn, Utz Settmacher, Falk Rauchfuβ
OBJECTIVES: Perihilar cholangiocarcinoma (Klatskin tumor) is a rare tumor entity, which is diagnosed late due to uncharacteristic symptoms. The therapeutic strategy for cure is still liver resection. Liver transplant in cases of locally irresectable tumors represents an alternative potential curative therapy for a select group of patients. MATERIALS AND METHODS: We present our data of 22 patients with irresectable Klatskin tumors who received transplants between 1996 and 2015...
June 18, 2018: Experimental and Clinical Transplantation
Koji Nanmoku, Akira Kurosawa, Taro Kubo, Takahiro Shinzato, Toshihiro Shimizu, Takaaki Kimura, Takashi Yagisawa
OBJECTIVES: Although steroid withdrawal has been attempted to ameliorate various complications in kidney transplant recipients, a steroid-sparing strategy has more frequently led to acute rejection. We investigated the use of everolimus to safely overcome steroid withdrawal in kidney transplant recipients with posttransplant diabetes mellitus under maintenance immunosuppressive therapy. MATERIALS AND METHODS: A total of 75 de novo consecutive kidney transplant recipients received conventional immunosuppressive therapy comprising tacrolimus (trough level of 5 ng/mL), mycophenolate mofetil (1000 mg), and methylprednisolone (4 mg)...
June 18, 2018: Experimental and Clinical Transplantation
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