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Experimental and Clinical Transplantation

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https://www.readbyqxmd.com/read/28810825/regulatory-t-cell-levels-in-the-longest-surviving-asian-patient-after-heart-lung-transplant
#1
Lei Huang, Ming Ji, Shounan Yi, Xinmin Zhou
Heart-lung transplant is the most effective therapy for patients with end-stage cardiopulmonary disease. Here, we report an initial assessment of a 31-year-old man who had survived more than 11 years after heart-lung transplant, which represents the longest survival time in this procedure in Asian studies. At his 11th anniversary after transplant, extensive tests were carried out, especially to detect regulatory T-cell levels for the first time in a surviving heart-lung transplant recipient. Preliminarily data revealed the status of his immunologic function in relation to chronic allograft rejection...
August 13, 2017: Experimental and Clinical Transplantation
https://www.readbyqxmd.com/read/28810824/laparoscopic-donor-nephrectomy-early-experience-at-a-single-center-in-pakistan
#2
Rehan Mohsin, Asad Shehzad, Uspal Bajracharya, Bux Ali, Tahir Aziz, Muhammed Mubarak, Altaf Hashmi, Adibul Hasan Rizvi
OBJECTIVES: Laparoscopic donor nephrectomy has become the criterion standard for kidney retrieval from living donors. There is no information on the experience and outcomes of laparoscopic donor nephrectomy in Pakistan. The objective of the study was to identify benefits and harms of using laparoscopic compared with open nephrectomy techniques for renal allograft retrieval. MATERIALS AND METHODS: In this a retrospective study, patient files from May 2014 to September 2015 were analyzed...
August 13, 2017: Experimental and Clinical Transplantation
https://www.readbyqxmd.com/read/28810823/validation-of-ultrasonographic-kidney-volume-measurements-a-reliable-imaging-modality
#3
Shiromani Janki, Hendrikus J A N Kimenai, Marcel L Dijkshoorn, Caspar W N Looman, Joy S Dwarkasing, Jan N M IJzermans
OBJECTIVES: To investigate the kidney selection procedure before donation to maximize donor safety, we investigated whether ultrasonographic measurements of kidney volume are comparable with computed tomography measurements. Predonation volume and increases in kidney size may be important indicators of renal function after donation and subsequent loss of function. MATERIALS AND METHODS: Consecutive donors with predonation computed tomography scans were approached preoperatively for additional ultrasonographic examinations...
August 13, 2017: Experimental and Clinical Transplantation
https://www.readbyqxmd.com/read/28800720/jc-virus-related-progressive-multifocal-leukoencephalopathy-after-living-donor-liver-transplant-a-rare-case
#4
Archana Rastogi, Natasha Gulati, Chhagan Bihari, Ashok Chaudhary, Kalpana Bansal, Shridhar Sasturkar, Shalini Thapar, Viniyendra Pamecha
Progressive multifocal leukoencephalopathy caused by polyoma JC virus is a rare and severe demyelinating disease of the central nervous system. It occurs in immunocompromised patients and is scarcely reported in liver transplant recipients. Brain biopsy demonstrating demyelination with presence of foamy macrophages, relative preservation of axons, astrogliosis, and typical polyomavirus inclusions in the enlarged oligodendroglial nuclei is essential for diagnosis. Here, we report a case of JC virus-associated progressive multifocal leukoencephalopathy in a living-donor liver transplant recipient who was transplanted for hepatitis C virus-related decompensated cirrhosis...
August 12, 2017: Experimental and Clinical Transplantation
https://www.readbyqxmd.com/read/28760119/autologous-stem-cell-rescue-for-graft-failure-of-second-allogeneic-stem-cell-transplant-after-engraftment-of-primary-allogeneic-transplant
#5
Atsushi Watanabe, Takeshi Inukai, Koshi Akahane, Shinpei Somazu, Hiroko Oshiro, Kumiko Goi, Keiichi Koizumi, Norikazu Harii, Kenichi Matsuda, Kanji Sugita
Here, we describe a case of primary graft failure with severe sepsis in a boy who experienced frequent relapses of osteosarcoma. The patient had undergone haploidentical bone marrow transplant after engraftment of unrelated cord blood transplant performed 10 months earlier. Considering his severe condition, we transfused autologous peripheral stem cells along with a single dose of etoposide (50 mg/m2). Granulocyte engraftment was confirmed on human leukocyte antigen-microsatellite analysis of bone marrow on day 14...
July 31, 2017: Experimental and Clinical Transplantation
https://www.readbyqxmd.com/read/28760118/renal-transplant-in-the-abnormal-bladder-long-term-follow-up
#6
Baher Salman, Ahmed Hassan, Sultan Sultan, Paul Tophill, Ahmed Halawa
OBJECTIVES: Normal urinary bladder stores urine at low pressure, does not leak, and completely empties by natural voiding. An abnormal bladder may be due to neurologic or urologic disorders that render the bladder of small capacity, of high storage pressure, or of poor compliance. The aim of this study was to determine the long-term outcomes of renal transplant in patients with abnormal bladders. MATERIALS AND METHODS: We retrospectively compared 30 transplanted kidneys in 25 patients with abnormal bladders with a control group comprising 30 grafts transplanted simultaneously during the same period of time (1990-2014) in 30 patients without bladder abnormality...
July 31, 2017: Experimental and Clinical Transplantation
https://www.readbyqxmd.com/read/28760117/successful-transplant-of-a-nonagenarian-liver-graft-with-fully-replaced-right-hepatic-artery-reconstruction
#7
Davide Ghinolfi, Desirée Gianardi, Giulia Cirillo, Paolo De Simone, Daniele Pezzati, Giuseppe Arenga, Valentina Battaglia, Franco Filipponi
Organ shortage and increasing donor age in liver transplant are stimulating transplant centers to accept otherwise discarded grafts due to donor age or vascular abnormalities; nevertheless, the use of nonagenarian donor grafts is uncommon because advanced age is associated with a higher risk of ischemic-type biliary lesions and worse long-term graft survival. We herein report the case of a 90-year-old donor with fully replaced right hepatic artery. After back-table vascular assessment, the donor right hepatic artery was anastomosed end-to-end with the gastroduodenal artery with 2 polypropylene 8/0 running sutures...
July 31, 2017: Experimental and Clinical Transplantation
https://www.readbyqxmd.com/read/28760115/a-model-of-acute-antibody-mediated-renal-allograft-rejection-in-the-sensitized-rata
#8
Sharmila Ramessur Chandran, William R Mulley, John Kanellis, David J Nikolic-Paterson, Frank Y Ma
OBJECTIVES: Antibody-mediated rejection in transplant recipients with preexisting donor-specific antibodies is a challenging clinical situation. However, we lack suitable animal models to study this scenario. The aim of this study was to develop an animal model of acute antibody-mediated rejection of renal allografts in sensitized recipients. MATERIALS AND METHODS: We used major histocompatibility complex class I and II incompatible rat strains (Dark Agouti RT1av1 and Lewis RT1l), which develop aggressive rejection...
July 31, 2017: Experimental and Clinical Transplantation
https://www.readbyqxmd.com/read/28697720/early-onset-pneumonia-after-liver-transplant-microbial-causes-risk-factors-and-outcomes-mansoura-university-egypt-experience
#9
Mohammad Khairy El-Badrawy, Raed El-Metwaly Ali, Amr Yassen, Mohammad Ahmad AbouElela, Rehab Ahmad Elmorsey
OBJECTIVES: Pneumonia has a negative effect on the outcome of liver transplant. Our aim was to analyze early-onset pneumonia that developed within the first month after transplant. MATERIALS AND METHODS: This prospective single-center study included 56 adult living-donor liver transplant recipients; those who developed early-onset pneumonia based on clinical and radiologic criteria were investigated as to causative pathogens and then followed up and compared with other recipients without pneumonia to illustrate risk factors, outcomes, and related mortality of posttransplant pneumonia...
July 11, 2017: Experimental and Clinical Transplantation
https://www.readbyqxmd.com/read/28697719/high-position-of-the-third-renal-transplant-and-alternative-urinary-tract-reconstruction-in-a-complicated-case
#10
Wilhelmina M van den Dool, Andrzej G Baranski
The decision-making process for treatment of patients with end-stage renal failure, multiple failed renal transplants, and severe comorbidities can be exceedingly difficult due to the inapplicability of many common surgery methods. In this article, we report the treatment of such a patient who underwent a third renal transplant and subsequently developed a ureteral stenosis. The third kidney had been transplanted with a high abdominal position and a partially intra- and retroperitoneally placed ureter due to a bilaterally obtained iliac fossa and severe abdominal adhesions...
July 11, 2017: Experimental and Clinical Transplantation
https://www.readbyqxmd.com/read/28697718/high-survival-and-mortality-characteristics-in-heart-transplant-patients-at-a-national-institute
#11
Christian Rojas, Gabriel De la Cruz-Ku, Amr Yassen, Bryan Valcarcel-Valdivia
OBJECTIVES: The identification of variables related to the survival of heart transplant patients is vital for a good medical practice. Few studies have examined this issue in a Latin American population. Therefore, the aim of this study was to analyze, retrospectively, the survival and mortality characteristics of patients after heart transplant. MATERIALS AND METHODS: Information on patients was obtained through review of medical records; we collected information on all patients who underwent this procedure from 2010 to 2015...
July 11, 2017: Experimental and Clinical Transplantation
https://www.readbyqxmd.com/read/28697717/timing-and-predictors-of-early-urologic-and-infectious-complications-after-renal-transplant-an-analysis-of-a-new-york-statewide-database
#12
Wilson Sui, Michael J Lipsky, Justin T Matulay, Dennis J Robins, Ifeanyi C Onyeji, Maxwell B James, Marissa C Theofanides, Sven Wenske
OBJECTIVES: The most common complications after renal transplant are urologic and are a cause of significant morbidity in a vulnerable population. We sought to characterize the timing and predictors of urologic complications after renal transplant using a statewide database. MATERIALS AND METHODS: We queried the New York Statewide Planning and Research Cooperative System database to identify patients who underwent renal transplant from 2005 to 2013. Postoperative complications included hydronephrosis, ureteral stricture, vesicoureteral reflux, nephrolithiasis, and urinary tract infections...
July 11, 2017: Experimental and Clinical Transplantation
https://www.readbyqxmd.com/read/28697716/case-series-of-10-patients-with-cirrhosis-undergoing-emergent-repair-of-ruptured-umbilical-hernias-natural-history-and-predictors-of-outcomes
#13
Miguel Malespin, Christopher M Moore, Andre Fialho, Silvio W de Melo, Tamara Benyashvili, Anai N Kothari, Diego di Sabato, Eric R Kallwitz, Scott J Cotler, Amy D Lu
OBJECTIVES: Ascites represents an important event in the natural history of cirrhosis, portending increased 1-year mortality. Umbilical herniation with rupture is an uncommon complication of large-volume ascites that is associated with significant morbidity and mortality. The aim of this study was to describe predictors of outcomes in patients undergoing emergent repair for spontaneous umbilical hernia rupture. MATERIALS AND METHODS: We report a case series of 10 patients with decompensated cirrhosis (mean age 66 ± 9 years, mean Model for End-Stage Liver Disease score of 21 ± 7) who presented with a ruptured umbilical hernia and had emergent repair...
July 11, 2017: Experimental and Clinical Transplantation
https://www.readbyqxmd.com/read/28697715/conversion-from-once-daily-prolonged-release-tacrolimus-to-once-daily-extended-release-tacrolimus-in-stable-liver-transplant-recipients
#14
Mario Altieri, Guillaume Delaval, Elisabeth Kimmoun, Manon Allaire, Ephrem Salamé, Jérôme Dumortier
OBJECTIVES: After organ transplant, strategies to simplify the therapeutic regimen may improve adherence and prevent rejection and/or graft loss. The aim of the present study was to evaluate the safety of conversion from once-daily prolonged-release tacrolimus (Advagraf; Astellas Pharma Europe Limited, Middlesex, UK) to once-daily extended-release tacrolimus (Envarsus; Chiesi SAS, Nanterre, France) in stable adult liver transplant recipients. MATERIALS AND METHODS: This observational study inclu-ded 44 liver transplant patients (median age of 59 y; 63...
July 11, 2017: Experimental and Clinical Transplantation
https://www.readbyqxmd.com/read/28697714/association-between-overweight-and-renal-transplant-outcomes-a-meta-analysis
#15
Congran Li, Hailong Jin, Li Xiao, Zhouli Li, Ming Cai, Bingyi Shi
OBJECTIVES: Our study aimed to evaluate the effects of being overweight on kidney transplant. MATERIALS AND METHODS: Our study evaluated kidney transplant recipients with body mass index ranging from 25 to 30 kg/m² versus patients with body mass index ranging from 18.5 to 29.9 kg/m², who were identified through PubMed, Embase, and Cochrane Library searches up to October 2015. Outcomes analyzed included delayed graft function, acute rejection, graft loss, and patient survival...
July 11, 2017: Experimental and Clinical Transplantation
https://www.readbyqxmd.com/read/28666406/posttransplant-lymphoproliferative-disease-and-inhibitors-of-mammalian-target-of-rapamycin-when-a-quick-look-back-can-change-the-perspective
#16
Lorena Castillo-Eraso, Edoardo Melilli, Carmen Cabre, Anna Manonelles, Julieta Landeyro, Oriol Bestard, Josep M Cruzado, Alberto Martinez-Vea
Posttransplant lymphoproliferative disease represents a heterogeneous group of diseases characterized by uncontrolled proliferation of lymphocytes, favored by immunosuppression. Several risk factors for its development have been described, with Epstein-Barr virus infection being a main cause of early-onset forms and chronic antigen stimulation of donors and/or accumulated immunosuppression as key factors of later forms of lymphocyte transformation. The present clinical case presents a patient diagnosed with posttransplant lymphoproliferative disease 3 years after renal transplant who had a potentially lethal complication related to conversion to inhibitors of mammalian target of rapamycin...
June 28, 2017: Experimental and Clinical Transplantation
https://www.readbyqxmd.com/read/28664822/passenger-lymphocyte-syndrome-in-the-abo-incompatible-kidney-transplant-recipient-receiving-rituximab
#17
Shunji Nishide, Junji Uchida, Kazuya Kabei, Tomoaki Iwai, Nobuyuki Kuwabara, Toshihide Naganuma, Norihiko Kumada, Yoshiaki Takemoto, Tatsuya Nakatani
Passenger lymphocyte syndrome is a rare but important disease in which the donor lymphocytes produce antibodies to the red blood cell antigens of the recipient, causing alloimmune hemolysis. It occurs in ABO blood group-mismatched solid-organ and/or bone marrow transplant. We report a case of passenger lymphocyte syndrome occurring after ABO-incompatible kidney transplant. The recipient received rituximab as a desensitization protocol. On posttransplant day 18, the recipient showed a fall in her hemoglobin levels without identifiable bleeding source and an elevation of total bilirubin...
June 28, 2017: Experimental and Clinical Transplantation
https://www.readbyqxmd.com/read/28664821/de-novo-iga-nephropathy-in-a-renal-allograft
#18
Amir Shabaka, Isabel Pérez-Flores, José Antonio Cortés, Ana Isabel Sánchez-Fructuoso
Posttransplant glomerulonephritis is a complication of kidney transplant that can impair graft function and long-term graft survival. De novo immunoglobulin A disease in kidney allografts appears to be much less common than the recurrent disease, and in most cases it is diagnosed in protocol biopsies with no clinical evidence of disease or in association with other renal transplant pathologies such as chronic rejection. We present a case of de novo immunoglobulin A nephropathy presenting with overt proteinuria, microscopic hematuria, and progressive deterioration of renal function 30 months after renal transplant...
June 28, 2017: Experimental and Clinical Transplantation
https://www.readbyqxmd.com/read/28661315/new-onset-diabetes-after-transplant-in-a-sudanese-renal-transplant-population-prevalence-and-risk-factors
#19
Ihab Abdel-Rahim Mohamed Ahmed, Rafaa K H Osman, Nazik O Khalifa, Manal Omar Ismail, Tayeb A Musa
OBJECTIVES: New-onset diabetes after transplant is a well-recognized complication of solid-organ transplant. The true incidence of this complication in Sudan is not known. The aim of this study was to define the prevalence of new-onset diabetes after transplant in a Sudanese renal transplant population and to identify the contributing risk factors. MATERIALS AND METHODS: Fifty-nine patients who underwent living-donor related kidney transplant and who were followed for 2 years were included in this pilot study...
June 28, 2017: Experimental and Clinical Transplantation
https://www.readbyqxmd.com/read/28661314/effect-of-single-sensitization-event-on-human-leukocyte-antigen-alloimmunization-in-kidney-transplant-candidates-a-single-center-experience
#20
Marianna Resse, Rossella Paolillo, Biagio Pellegrino Minucci, Dario Costa, Carmela Fiorito, Michele Santangelo, Paride De Rosa, Claudio Napoli
OBJECTIVES: Human leukocyte antigen alloimmunization is caused by exposure to HLA antigens through transfusion, pregnancy, or transplant. Our study objective was to present the rate of positivity of anti-HLA antibody considering the effects of a single sensitization event in kidney transplant candidates at our center. MATERIALS AND METHODS: Our study reviewed 606 kidney transplant candidates. Patient sera were analyzed using Luminex xMAP technology. Panel reactive antibody positivity rates and antibody strengths in patients were analyzed according to a single sensitization event...
June 28, 2017: Experimental and Clinical Transplantation
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