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Experimental and Clinical Transplantation

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https://www.readbyqxmd.com/read/28187700/long-term-body-mass-index-trends-after-living-donor-nephrectomy
#1
Christopher J Dru, Gerhard J Fuchs
OBJECTIVES: As the demand for kidney transplant allografts has increased, many centers are expanding the upper limit of acceptable body mass index for kidney donors. However, obesity is a risk factor for developing renal disease. Our goal was to quantify body mass index trends in donor nephrectomy patients and to institute nutrition counseling to promote sustainable weight loss to reduce the risk of metabolic syndrome-derived renal dysfunction. MATERIALS AND METHODS: Ninety patients who underwent donor nephrectomy between 2007 and 2012 consented to having height and weight data collected at multiple time points...
February 11, 2017: Experimental and Clinical Transplantation
https://www.readbyqxmd.com/read/28176620/epidemiology-of-infectious-complications-in-renal-allograft-recipients-in-the-first-year-after-transplant
#2
Afsane Bahrami, Seyyede Fatemeh Shams, Elham Shaarbaf Eidgahi, Zahra Lotfi, Maryam Sheikhi, Sepideh Shakeri
OBJECTIVES: Renal transplant is one of the best ways to extend life of patients in the end stage of renal disease. Infections are significant causes of morbidity and mortality after renal transplant. The aim of this study was to evaluate frequency, risk factors, causative pathogens, and clinical manifestations in renal transplant recipients from Mashhad City during the first year after transplant. MATERIALS AND METHODS: This research was conducted at Montaserie Hospital of Mashhad University of Medical Sciences from March 2013 to July 2015...
February 7, 2017: Experimental and Clinical Transplantation
https://www.readbyqxmd.com/read/28176619/inferior-vena-cava-replacement-in-living-donor-liver-transplant-for-hepatocellular-carcinoma-first-case-report-in-saudi-arabia
#3
Firas Zahr Eldeen, Mohammed Rabie Abdulfatah, Dieter Broering
Living-donor liver transplant for hepatocellular carcinoma located on hepatocaval confluence or in contact with the inferior vena cava is technically challenging, and candidates for this kind of procedure should be carefully selected. It is difficult to rule out major vascular invasion except after hepatectomy and histologic examination; in addition, the possible dissemination of cancer cells during recipient hepatectomy is a considerable risk. Herein, we report the first case in Saudi Arabia of right lobe living-donor liver transplant combined with inferior vena cava reconstruction using cryopreserved iliac vein graft after en bloc resection of the liver with part of the diaphragm, anterior wall of retrohepatic inferior vena cava, and a 5-cm hepatocellular carcinoma in segment 7...
February 7, 2017: Experimental and Clinical Transplantation
https://www.readbyqxmd.com/read/28176618/experience-of-liver-transplant-in-patients-diagnosed-with-budd-chiari-syndrome
#4
Syed Muhammad Raza, Saima Zainab, Ali Reza Shamsaeefar, Saman Nikeghbalian, Seyed Ali Malek Hosseini
OBJECTIVES: Budd-Chiari syndrome can lead to fulminant hepatic failure and cirrhosis. The treatment depends on the severity of disease. Liver transplant is a successful treatment option for those with advanced-stage disease. MATERIALS AND METHODS: In this retrospective study, we analyzed all liver transplants conducted for Budd-Chiari syndrome at the organ transplant unit of Shiraz University of Medical Sciences, Iran, from 1993 to January 2016. Overall, 3201 liver transplant procedures were performed...
February 7, 2017: Experimental and Clinical Transplantation
https://www.readbyqxmd.com/read/28176617/progressive-multifocal-leukoencephalopathy-in-a-kidney-transplant-recipient
#5
Federico Cicora, Javier Roberti
Progressive multifocal leukoencephalopathy (PML) is a debilitating and often fatal viral disease of the central nervous system. A 39-year-old male kidney transplant recipient presented to our hospital with weakness of the left arm and leg, his immunosuppressive regimen consisted of tacrolimus, mycophenolate sodium, and meprednisone. Magnetic resonance imaging of the brain revealed hypercellularity in neural tissue and a lesion affecting the right ventral and lateral areas of the thalamus and the posterior limb of the internal capsule...
February 7, 2017: Experimental and Clinical Transplantation
https://www.readbyqxmd.com/read/28176616/different-courses-of-hepatitis-b-reinfection-after-renal-transplant-a-case-report
#6
Ozan Yegit, Erol Demir, Yasar Caliskan, Halil Yazici, Mehmet Sukru Sever
Hepatitis B surface antigen-positive allografts may be a source of transmission in patients who undergo renal transplantation. Treatment of hepatitis B virus infection with nucleoside/nucleotide analogs in kidney recipients who have hepatitis B virus infection or who have received transplants from hepatitis B surface antigen-positive donors improves long-term patient survival. Antiviral agents are administered as a preemptive or prophylactic therapy at the time of kidney transplantation, rather than as salvage treatment...
February 7, 2017: Experimental and Clinical Transplantation
https://www.readbyqxmd.com/read/28137205/delayed-chest-closure-with-skin-approximation-after-lung-transplant-in-oversized-graft
#7
Prashant N Mohite, Anton Sabashnikov, Aron-Frederik Popov, Mohamed Zeriouh, Javid Fatullayev, Massimo Cappocia, Mohamed Amrani, Martin Carby, André R Simon
Closure of the chest after lung transplant in cases of oversized grafts is often difficult. Lung volume reduction and delayed closure of the chest with Bogota bag are the only options available in such situations. Here, we propose to keep the sternum and intercostal spaces open and approximate skin over it. Once lung function improves and reperfusion-related edema recovers, the chest can be closed.
January 31, 2017: Experimental and Clinical Transplantation
https://www.readbyqxmd.com/read/28137206/biopsy-proven-bk-virus-associated-nephropathy-clinico-pathologic-correlations
#8
Sarah Jahdali, Noura Al Oudah, Khaled O Alsaad, Hala Kfoury, Salem Qurashi, Abdulla Al Sayyari
OBJECTIVES: Our objective was to study the clinico-pathologic correlations in BK virus nephropathy. MATERIALS AND METHODS: We conducted a retrospective study of all patients with biopsy-proven polyoma (BK) virus infection. We compared their survival and renal outcomes versus BK virus-negative patients with biopsy-proven graft rejection. Histopathologic characterization by a blinded nephropathologist was performed. RESULTS: BK nephropathy was found in 10 patients biopsied for graft dysfunction...
January 30, 2017: Experimental and Clinical Transplantation
https://www.readbyqxmd.com/read/28128721/effect-of-right-posterior-bile-duct-anatomy-on-biliary-complications-in-patients-undergoing-right-lobe-living-donor-liver-transplant
#9
Tugan Tezcaner, Nadire Dinç, Feza Y Karakayalı, Mahir Kırnap, Mehmet Coşkun, Gökhan Moray, Mehmet Haberal
OBJECTIVES: Our aim was to evaluate the influence of the localization of right posterior bile duct anatomy relative to portal vein of the donors on posttransplant bile duct complications. MATERIALS AND METHODS: We retrospectively investigated 141 patients who had undergone living donor liver transplant using right hemiliver grafts. The patients were classified based on the pattern of the right posterior bile duct and divided into infraportal and supraportal types...
January 27, 2017: Experimental and Clinical Transplantation
https://www.readbyqxmd.com/read/28128720/surgical-complications-after-pediatric-renal-transplant
#10
Hakan Sözen, Kibriya Fidan, Onur Özen, Oğuz Söylemezoğlu, Aydın Dalgıç
OBJECTIVES: Renal transplant is the most appropriate treatment for both adult and pediatric patients with end-stage renal failure. Here, we analyzed surgical complications after pediatric renal transplant at our center. MATERIALS AND METHODS: We retrospectively analyzed data from patient files and hospital charts of pediatric patients who had renal transplant at our center (Gazi University, Ankara, Turkey). Our immunosuppression protocol, a calcineurin inhibitor-based triple regimen, was applied to all recipients (steroids, mycophenolic acid)...
January 27, 2017: Experimental and Clinical Transplantation
https://www.readbyqxmd.com/read/28031007/polymorphisms-of-the-costimulatory-genes-ctla-4-cd28-pd-1-and-icos-and-outcome-of-kidney-transplants-in-iranian-patients
#11
Ahmad Niknam, Mohammad Hossein Karimi, Bita Geramizadeh, Jamshid Roozbeh, Ramin Yaghobi, Mehdi Salehipour
OBJECTIVES: Costimulatory molecules are important factors determining the outcome of transplant. The aim of the present study was to investigate the effect of CTLA-4, CD28, PD-1, and ICOS gene polymorphisms on the outcome of kidney transplant. MATERIALS AND METHODS: A total of 172 kidney transplant recipients were included in this study. There were 45 recipients (26%) who experienced acute rejection. The CTLA-4, PD-1, ICOS, and CD28 gene polymorphisms were evaluated by polymerase chain reaction and restriction fragment length polymorphism methods...
December 27, 2016: Experimental and Clinical Transplantation
https://www.readbyqxmd.com/read/28005001/recurrent-urinary-tract-infection-among-renal-transplant-recipients-risk-factors-and-long-term-outcome
#12
Khaled Abdel Tawab, Osama Gheith, Torki Al Otaibi, Naryanam Nampoory, Hany Mansour, Medhat A Halim, Prasad Nair, Tarek Said, Mohamed Abdelmonem, Ayman El-Sayed, Waleed Awadain
OBJECTIVES: Urinary tract infection is the most common type of bacterial infection in kidney transplant procedures, with adverse effects on graft and patient survival. We aimed to evaluate the risk factors of recurrent urinary tract infection in renal transplant recipients and its impact on patient and graft survival. MATERIALS AND METHODS: In a cohort of 1019 patients who were transplanted between 2000 and 2010 at Hamed Al-Essa Organ Transplant Center in Kuwait, 86% developed at least 1 episode of urinary tract infection, with only 6...
December 22, 2016: Experimental and Clinical Transplantation
https://www.readbyqxmd.com/read/28005000/nonsurgically-treated-sigmoid-volvulus-in-a-young-patient-3-days-after-renal-transplant
#13
İsmail Bilgiç, Mehmet Tolga Kafadar, Işılay Nadir, Mukaddes Ayşe Bilgiç, Ali Akçay, Aydın Dalgıç
Sigmoid volvulus is a rare clinical condition in young individuals. It should be accurately diagnosed and treated in a rapid manner. Surgical and nonsurgical conservative methods are used for the treatment of sigmoid volvulus. Patients having no signs of perforation or peritonitis should be primarily treated by colonoscopic detorsion. A delay in the diagnosis and treatment of this condition may cause significant morbidity and mortality in an immunosuppressed patient with newly performed renal transplant and diffuse abdominal pain...
December 22, 2016: Experimental and Clinical Transplantation
https://www.readbyqxmd.com/read/28004998/de-novo-vascular-lesions-after-liver-transplant-in-a-case-with-hereditary-hemorrhagic-telangiectasia-and-fibropolycystic-liver-disease-long-term-follow-up-with-magnetic-resonance-imaging-and-magnetic-resonance-angiography
#14
Sila Ulus, Aydan Arslan, Ercan Karaarslan, Yilmaz Cakaloglu
We report a case of a 62-year-old woman who received a liver transplant 19 years previously for end-stage liver disease due to hereditary hemorrhagic telangiectasia and fibropolycystic liver disease. During long-term follow-up 8 years after the liver transplant, de novo vascular lesions were detected with magnetic resonance imaging and magnetic resonance angiography. Hepatic vascular lesions had slowly progressed, despite no symptoms. To our knowledge, there are few reports in the English literature of de novo vascular lesions after liver transplant in patients with hepatic telangiectasias...
December 22, 2016: Experimental and Clinical Transplantation
https://www.readbyqxmd.com/read/28004997/effect-of-long-term-low-dose-aspirin-therapy-on-renal-graft-function
#15
Hatem Ali, Ahmed Shaaban, Asam Murtaza, Laura E Howell, Aimun Ahmed
OBJECTIVES: Despite improvements in immunosuppressive protocols for renal transplant, long-term success of renal transplant is still limited by the occurrence of interstitial fibrosis and tubular atrophy. Some studies have shown that aspirin decreases the severity of kidney ischemia-reperfusion injury and the development of tubular atrophy in animal models. This study aimed to assess the effects of aspirin therapy started at the time of transplant on long-term graft function. MATERIALS AND METHODS: We compared renal graft function of 82 patients on low-dose aspirin 75 mg once daily who underwent renal transplant between 1 January 2000 and 31 December 2010 from a single center with 65 patients not taking aspirin...
December 22, 2016: Experimental and Clinical Transplantation
https://www.readbyqxmd.com/read/27938318/incisional-infections-after-renal-transplant-outcome-data-from-238-consecutive-recipients
#16
Demetrios Moris, Spyridon Davakis, Kiriaki Kakavia, John Bokos, Spyridon Vernadakis, Konstantinos Diles, Georgios Sotirchos, Alexandros Barlas, Mina Psychogiou, Georgios Zavos
OBJECTIVES: Surgical incision infections, along with urinary tract infections, are among the most common infective complications after kidney transplant. The aim of this retrospective study is to evaluate the incidence and predisposing factors of surgical incision infection development in renal transplant recipients. MATERIALS AND METHODS: Between 1 January 2012 and 31 December 2015, there were 238 consecutive kidney transplant procedures performed in our unit. Of these, 146 patients received deceased donor kidney allografts and 92 had transplants from living related donors...
December 12, 2016: Experimental and Clinical Transplantation
https://www.readbyqxmd.com/read/27938317/cell-viability-of-human-embryonic-stem-cells-stored-for-a-period-of-9-years
#17
Geeta Shroff, Damini Vatsa
OBJECTIVES: Human embryonic stem cells are pluripotent cell lines usually derived from human blastocysts. Their potential critically depends on long-term proliferative capacity, developmental potential after prolonged culture, and karyotypic stability. Cell viability is an important parameter for assessing cell sample quality. Here, we elaborate the stored human embryonic stem cell lines' viability in a ready to use form for a period of 9 years (from 2007 to 2015). MATERIALS AND METHODS: Spare pre implantation stage in vitro fertilized ovum-derived cell lines were cultured in suitable media...
December 12, 2016: Experimental and Clinical Transplantation
https://www.readbyqxmd.com/read/27938315/epilepsy-after-heart-transplant-a-single-center-experience
#18
Ruhsen Öcal, Taner Sezer, Seda Kibaroğlu, Eda Derle, Sibel Benli, Atilla Sezgin, Sait Aşlamacı
OBJECTIVES: Cardiac transplant is the best treatment for patients with end-stage heart failure. Neurologic complications occur at a rate of 30% to 80% in patients undergoing cardiac transplant. Seizures occur at a rate of 2% to 20%. The main causative factors include immunosuppressant drug toxicity, infections, brain lesions, and metabolic disorders. Here, our aim was to determine seizure types and associated conditions in patients undergoing cardiac transplant and to report our treatment experience at our institution...
December 12, 2016: Experimental and Clinical Transplantation
https://www.readbyqxmd.com/read/27938314/sequential-onset-of-varicella-zoster-virus-encephalomeningitis-and-progressive-multifocal-leukoencephalopathy-in-an-allogeneic-hematopoietic-stem-cell-transplant-recipient
#19
Yukiko Yamashita, Shinsuke Kusakabe, Jun Toda, Kenji Ohshima, Hiroaki Masaie, Toshinari Yagi, Hitoshi Yoshida, Jun Ishikawa
Here, we describe a case of sequential varicella-zoster virus encephalomeningitis and progressive multifocal leukoencephalopathy following an allogeneic hematopoietic stem cell transplant procedure. A 37-year-old male patient presented with fever, incomplete paralysis of bilateral legs, and bullous eruptions 8 months after allogeneic transplant. Polymerase chain reaction assays of cerebrospinal fluid samples for varicella-zoster virus were positive. Bullous eruptions and incomplete paralysis of bilateral legs improved after administration of acyclovir...
December 12, 2016: Experimental and Clinical Transplantation
https://www.readbyqxmd.com/read/27915968/peripheral-t-cell-lymphoma-a-posttransplant-lymphoproliferative-disorder-presenting-as-a-jejunal-mass-in-a-renal-transplant-recipient
#20
Aanchal Kakkar, Immanuel Pradeep, Geetika Singh, Amit Dinda, Sanjay K Agarwal
Posttransplant lymphoproliferative disorders are a spectrum of lymphoproliferative disorders seen in recipients of solid-organ, bone marrow, and stem cell allografts. They include polyclonal early lesions mimicking infectious mononucleosis and monoclonal proliferations of B and T cells, indistinguishable from lymphomas occurring in immunocompetent individuals. Although most posttransplant lymphoproliferative disorders are B-cell neoplasms, T-cell posttransplant lymphoproliferative disorders are very rare. Among solid-organ transplants, renal allografts have low risk for development of posttransplant lymphoproliferative disorders...
December 2, 2016: Experimental and Clinical Transplantation
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