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Experimental and Clinical Transplantation

Eun Kyung Choi, Hoon Jung, Kyung-Ju Kim, So Jeong Kang, Hyun Jeong Kim, Jung A Lim, Kyung Hwa Kwak, Dong Gun Lim
OBJECTIVES: Nitrite as an alternative source of nitric oxide has been proposed, as it can mediate the protective response in the presence of ischemia or hypoxic conditions and inorganic nitrite can be reduced to nitric oxide by xanthine oxidoreductase. Here, we investigated whether pretreatment with sodium nitrite can attenuate liver damage in hepatic ischemia-reperfusion injury and identified the possible mechanism of nitrite reduction using 2-(4-carboxyphenyl)-4,5dihydro-4,4,5,5-tetramethyl-1H-imidazolyl-1-oxy-3oxide (C-PTIO), a nitric oxide scavenger, and allopurinol, a xanthine oxidoreductase inhibitor...
December 31, 2018: Experimental and Clinical Transplantation
Wei-Cheng Tseng, Hou-Chuan Lai, Chun-Chang Yeh, Hsiu-Lung Fan, Zhi-Fu Wu
Posterior reversible encephalopathy syndrome is a neurotoxic state accompanied by unique brain imaging patterns and neurologic abnormalities, typically associated with several complex clinical conditions such as preeclampsia/eclampsia, solid-organ transplant procedures, autoimmune diseases, and immunosuppressive agents. The detailed mechanism of posterior reversible encephalopathy syndrome is not known, and the current therapy is only supportive care. Here, we present a 33-year-old parturient woman with preeclampsia complicated with hemolysis, elevated liver enzymes, and low platelet syndrome, fulminant hepatitis B, acute fatty liver, and posterior reversible encephalopathy syndrome...
December 31, 2018: Experimental and Clinical Transplantation
Valérie Hage, Inès Ferrandiz, Julie Béllière, Laure Esposito, Anne Laure Hebral, Olivier Cointault, Arnaud Del Bello, Nassim Kamar
OBJECTIVES: Antibody-mediated rejection is a main cause of long-term kidney allograft loss. Nonad-herence and tacrolimus intrapatient variability have been identified as risk factors for developing de novo donor-specific antibodies. Tacrolimus, given once daily, can improve adherence and reduce variabilities among patients. The aim of this retrospective observational study was to compare the incidences of donor-specific antibodies at 2 years posttransplant in de novo kidney transplant recipients given tacrolimus either once or twice daily...
December 31, 2018: Experimental and Clinical Transplantation
Anne-Elisabeth Heng, Julien Aniort, Bruno Pereira, Fernando Fervenza, Yves Boirie, Mikel Prieto
OBJECTIVES: Previous studies have linked obesity to poor outcomes in renal transplant recipients, prompting many transplant centers to encourage weight loss pretransplant in obese patients. Here, we performed a single-center retrospective study to assess the effects of weight loss on graft and patient outcomes. MATERIALS AND METHODS: Data from 893 renal transplant recipients at our center from 2007 to 2011 were analyzed. First, renal transplant recipients with a history of obesity before transplant (42%) were compared with nonobese patients...
December 31, 2018: Experimental and Clinical Transplantation
Francesca Zanoni, Carlo Alfieri, Gabriella Moroni, Patrizia Passerini, Anna Regalia, Maria Meneghini, Piergiorgio Messa
West Nile virus infection is more frequently associated with neuroinvasive disease and high morbidity and mortality in immunocompromised hosts. Here, we describe a 47-year-old Egyptian kidney transplant recipient who was admitted to our department in 2016 for persistent fever, altered mental status, and upper limb tremors. In addition, renal impairment, signs of acute thrombotic microangiopathy, pancreatitis, and slightly altered inflammatory indices were present. The patient was treated with antibacterial and antiviral therapy, and reduced immunosuppressive therapy was prescribed...
December 31, 2018: Experimental and Clinical Transplantation
Usman H Haroon, Niall F Davis, Ponnusamy Mohan, Dilly M Little, Gordon Smyth, James C Forde, Richard E Power
OBJECTIVES: We reviewed the incidence, management, and survival outcomes of prostate cancer among kidney transplant recipients and compared these characteristics with a national population (nonrecipients). MATERIALS AND METHODS: A retrospective study was performed on all kidney transplant recipients from a National Kidney Transplant Centre who were subsequently diagnosed with prostate cancer. Primary outcome variables included comparisons of incidence and 5-year overall survival in kidney transplant recipients versus nonrecipients after treatment of prostate cancer...
December 31, 2018: Experimental and Clinical Transplantation
Mariarosaria Campise, Evaldo Favi, Piergiorgio Messa
OBJECTIVES: High recurrence and inferior graft survival rates have been reported for kidney transplant recipients with primary focal segmental glomerulosclerosis. Plasmapheresis is widely used to treat posttransplant relapsing focal segmental glomerulosclerosis, but the effectiveness of prophylactic plasmapheresis remains controversial. MATERIALS AND METHODS: In this single-center retrospective study, 21 adult deceased-donor kidney transplant recipients who received prophylactic plasmapheresis were analyzed...
December 20, 2018: Experimental and Clinical Transplantation
Karim M Soliman, Aurora C Posadas Salas, David J Taber
OBJECTIVES: Although both tacrolimus and mycophenolate have improved outcomes after kidney transplant, studies regarding effects of exposure on outcomes, specifically related to racial disparities, are sparse. MATERIALS AND METHODS: In this 8-year longitudinal cohort study of adult kidney transplant recipients, mycophenolate and tacrolimus levels were compared across transplant vintage stratified by non-African Americans versus African Americans. Data were analyzed with standard univariate tests and multivariable regression models...
December 20, 2018: Experimental and Clinical Transplantation
Vinayak Rohan, David Taber, Arun Palanisamy, John Mcgillicuddy, Kenneth Chavin, Prabhakar Baliga, Charles Bratton
OBJECTIVES: Pancreas transplant improves quality of life and survival of patients irrespective of pretransplant C-peptide levels. Our objectives were to examine complications and outcomes in patients without measureable C-peptide (insulin-dependent type 1 diabetes mellitus) and carefully selected patients with measurable C-peptide (insulin-dependent type 2 diabetes mellitus) after pancreas transplant. MATERIALS AND METHODS: We conducted a retrospective analysis to examine the demographic, transplant factors, complications, and outcomes in patients with nondetectable pretransplant C-peptide (insulin-dependent type 1 diabetes mellitus) and patients with detectable pretransplant C-peptide (insulin-dependent type 2 diabetes mellitus)...
November 28, 2018: Experimental and Clinical Transplantation
Rasha Kamal Abouelenein, Ayman Fathi Refaie, Yaser A Alhendy, Amir M Al Okily, Nabil Abdelfadil Elserwy, Mohamed Elsayed Mashaly, Mohamed Hamed Abbas, Mohamed Adel Bakr
OBJECTIVES: The goal when treating patients with end-stage renal disease is to increase patient survival and to provide a better quality of life, both of which can be achieved by kidney transplant. Identifying problems associated with kidney transplant is an essential step toward improved graft function. Here, we evaluated posttransplant erythrocytosis, a frequent complication among kidney transplant recipients. MATERIALS AND METHODS: In this single-center retro-spective study, we identified 1850 kidney transplant recipients who were transplanted at the Mansoura Urology and Nephrology Center (Mansoura University, Mansoura, Egypt) from 1990 and 2013...
November 28, 2018: Experimental and Clinical Transplantation
Michelle C Nguyen, Latifah Sage Silski, Musab Alebrahim, Sylvester Black, Elmahdi Elkhammas, Ken Washburn, Ashraf El-Hinnawi
OBJECTIVES: Large spontaneous splenorenal shunts can result in portal vein steal syndrome and is a risk factor for portal vein thrombosis after orthotopic liver transplant. Disconnection of these shunts by left renal vein ligation has been suggested as a potential technique for improving portal venous flow and mitigating risk of portal vein thrombus, thus improving graft perfusion. We present a series of 6 patients who underwent left renal vein ligation for spontaneous splenorenal shunts and their outcomes...
November 28, 2018: Experimental and Clinical Transplantation
Dávid Á Kovács, Andries E Braat, Volkert A L Huurman, Andrzej G Baranski
Simultaneous pancreas-kidney transplant is the ultimate therapy for patients who have uncontrolled and complicated type 1 diabetes mellitus with end-stage renal disease. The combined pancreas transplant provides a euglycemic milieu for the kidney and protects it from recurrence of diabetic complications. Our patient, a 41-year-old woman with end-stage diabetic nephropathy and history of multiple abdominal surgeries (ovarian cyst fenestration, adnexal extirpation, abdominal wall reconstruction), including urinary diversion (Bricker loop, above double J stent), underwent simultaneous pancreas-kidney transplant...
November 6, 2018: Experimental and Clinical Transplantation
Kemal Murat Haberal, Feride Kural Rahatlı, Hale Turnaoğlu, Gonca Özgün, Mehmet Coşkun
OBJECTIVES: Computed tomography liver volumetry has been widely used to detect total and segmental liver volume in living-donor liver transplantation. However, use of this technique to evaluate the cirrhotic liver remains unclear. In this study, we evaluated the accuracy of freehand computed tomography volumetry to assess total liver volume by comparing weights of total hepatectomy specimens in patients with cirrhosis. For our analyses, we considered the density of a cirrhotic liver to be 1...
November 6, 2018: Experimental and Clinical Transplantation
Feride Kural Rahatli, Hale Turnaoglu, Kemal Murat Haberal, Mahir Kirnap, Cihan Fidan, Cihat Burak Sayın, Nihal Uslu, Mehmet Haberal
OBJECTIVES: The Achilles tendon, which is composed of tendinous parts of gastrocnemius and soleus muscles, is the strongest and the largest tendon in the human body. Chronic renal disease can lead to reduced physical activity and exercise capacity. Spontaneous rupture of the Achilles tendon can occur in patients with chronic renal failure, with recurrent microtraumas, hypoxia, and chronic acidosis as predisposing factors. Here, we assessed and compared the elastographic findings in the Achilles tendon using acoustic radiation force impulse elastography in patients on chronic hemodialysis, in renal transplant patients, and in healthy volunteers...
November 6, 2018: Experimental and Clinical Transplantation
Cemalettin Koc, Sami Akbulut, Sezai Yilmaz
OBJECTIVES: This study aimed to compare the impact of deceased-donor organ procurement techniques (standard versus modified standard) on biochemical outcomes after liver transplant. MATERIALS AND METHODS: From February 2006 to December 2013, organs were recovered from 105 consecutive deceased donors by our transplant team. All organ procurement procedures were performed by a pioneer surgeon experienced in organ recovery from deceased donors. Donors were divided into those who had the abdominothoracic approach, which is referred to as the standard technique, and those who had the abdominal approach, which is referred to as the modified standard technique...
November 6, 2018: Experimental and Clinical Transplantation
Damir Pelicic, Batric Vukcevic, Darijo Bokan, Vesna Stojanovic, Nemanja Radojevic
OBJECTIVES: The aim of this research was to determine the attitudes of transplant-related health care workers and the local population of Montenegro toward organ donation and transplantation. MATERIALS AND METHODS: Our study included 200 transplant-related health care professionals (from the Clinical Center of Montenegro, the only transplant hospital in the country) and 200 volunteers from Podgorica (the capital of Montenegro). Their attitudes were evaluated using an anonymous, self-administered, multiple-choice questionnaire...
November 6, 2018: Experimental and Clinical Transplantation
Manon Allaire, Olivier Sérée, Audrey Coilly, Pauline Houssel-Debry, Martine Neau-Cransac, Georges-Philippe Pageaux, Jérôme Dumortier, Mario Altieri
No abstract text is available yet for this article.
December 2018: Experimental and Clinical Transplantation
Seong Hyuk Park, Seok-Chan Eun
The evolution and success of intestinal and multi-visceral transplantation over the past 20 years have raised the issue of difficult or even impossible abdominal closure, a topic rarely encountered in other fields of transplantation. Different techniques have been proposed to address this topic. The choice depends on the transplant team's expertise and/or the availability of a plastic surgery service. Abdominal wall transplant is a type of composite tissue allograft that can be utilized to reconstitute the abdominal domains of patients who undergo intestinal transplant, and the results are encouraging...
December 2018: Experimental and Clinical Transplantation
Antoine Barbari, Aline Milane, Pascale Salameh, Jennifer Abi Younis, Abir El Houjairy, Katia Safi, Ikram Sabaa Ayoun, Mahassen Jaafar, Line Bou Khalil, Ali Bachir, Nadine Bassil, Hussein Karnib, Nina Morad, Sylvana Rizk, Marwan Masri
OBJECTIVES: The relationship between chronic kidney disease and cardiovascular disease is complex and bidirectional. This relationship may be partially linked to thrombophilic genetic anomalies that may predispose to the progression of both diseases. MATERIALS AND METHODS: We analyzed blood samples from 102 Lebanese patients with end-stage renal disease and undergoing hemodialysis and 20 randomly selected healthy volunteers for frequencies of 12 cardiovascular disease gene mutations and traditional risk factors...
December 2018: Experimental and Clinical Transplantation
Yujie Jiang, Xiaosheng Fang, Xiaohui Sui, Xin Liu, Ying Li, Xianghua Wang, Hongzhi Xu, Lingyan Zhang, Xin Wang
OBJECTIVES: We evaluated the safety and efficacy of 2 conditioning regimens (busulfan/fludarabine vs modified busulfan/cyclophosphamide) in patients with acute myeloid leukemia undergoing haploidentical hematopoietic stem cell transplant. MATERAILS AND METHODS: Twenty patients with primary acute myeloid leukemia had been randomized into busulfan/fludarabine and modified busulfan/cyclophosphamide groups. We retrospectively compared hematopoietic engraftment, regimen-related toxicity, graft-versus-host disease, transplant-related mortality, leukemia-free survival, and overall survival between the groups...
December 2018: Experimental and Clinical Transplantation
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