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Acta Biochimica et Biophysica Sinica

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https://www.readbyqxmd.com/read/28177455/jak-stat-signaling-mediates-the-senescence-of-bone-marrow-mesenchymal-stem-cells-from-systemic-lupus-erythematosus-patients
#1
Juan Ji, Yeqing Wu, Yan Meng, Lijuan Zhang, Guijuan Feng, Yunfei Xia, Wenrong Xue, Shuyang Zhao, Zhifeng Gu, Xiaoyi Shao
No abstract text is available yet for this article.
February 8, 2017: Acta Biochimica et Biophysica Sinica
https://www.readbyqxmd.com/read/28159994/missing-in-metastasis-b-regulated-by-dnmt1-functions-as-a-putative-cancer-suppressor-in-human-lung-giant-cell-carcinoma
#2
Hong Wang, Xiaomin Yu, Xiaofang Wang, Xiaokun Li, Shulin Yang
No abstract text is available yet for this article.
February 4, 2017: Acta Biochimica et Biophysica Sinica
https://www.readbyqxmd.com/read/28159982/recombinant-human-sdf-1%C3%AE-administration-accelerates-aneurysm-neck-reendothelialization-in-rabbit-saccular-aneurysm-after-flow-diverter-treatment
#3
Zifu Li, Rui Zhao, Xinggen Fang, Qinghai Huang, Jianmin Liu
No abstract text is available yet for this article.
February 4, 2017: Acta Biochimica et Biophysica Sinica
https://www.readbyqxmd.com/read/28159979/rce1-expression-in-renal-cell-carcinoma-and-its-regulatory-effect-on-786-o-cell-apoptosis-through-endoplasmic-reticulum-stress
#4
Jianjun Li, Delin Wang, Junnan Liu, Yunlang Qin, Liangliang Huang, Qiangfeng Zeng, Maolin Xiao, Jie Hu, Qixin Yang, Jiang He, Li Mai, Ying Li, Wujiang Liu
No abstract text is available yet for this article.
February 4, 2017: Acta Biochimica et Biophysica Sinica
https://www.readbyqxmd.com/read/28159958/p-n1380del-mutation-in-the-pore-forming-region-of-scn5a-gene-is-associated-with-cardiac-conduction-disturbance-and-ventricular-tachycardia
#5
Zhen Yang, Danbo Lu, Lei Zhang, Jialu Hu, Zhenning Nie, Chang Xie, Fang Qiu, Hua Cheng, Yan Yan
No abstract text is available yet for this article.
February 4, 2017: Acta Biochimica et Biophysica Sinica
https://www.readbyqxmd.com/read/28119311/salubrinal-protects-against-clostridium-difficile-toxin-b-induced-ct26-cell-death
#6
Shuyi Chen, Chunli Sun, Huawei Gu, Haiying Wang, Shan Li, Yi Ma, Jufang Wang
Clostridium difficile(C. difficile) is considered to be the major cause of the antibiotic-associated diarrhea and pseudomembranous colitis in animals and humans. The prevalence of C. difficile infections (CDI) has been increasing since 2000. Two exotoxins of C. difficile, Toxin A (TcdA) and Toxin B (TcdB), are the main virulence factors of CDI, which can induce glucosylation of Rho GTPases in host cytosol, leading to cell morphological changes, cell apoptosis, and cell death. The mechanism of TcdB-induced cell death has been investigated for decades, but it is still not completely understood...
January 23, 2017: Acta Biochimica et Biophysica Sinica
https://www.readbyqxmd.com/read/28119310/activation-of-liver-x-receptors-promotes-inflammatory-cytokine-mrna-degradation-by-upregulation-of-tristetraprolin
#7
Ji Xiao, Quan Chen, Dan Tang, Weiwei Ou, Jiazheng Wang, Zhongcheng Mo, Chaoke Tang, Liangyu Peng, Deming Wang
Liver X receptors (LXRs) have anti-inflammatory properties. Whether LXRs play a role in post-transcriptional control of inflammatory cytokine expression is not clear. Here, we firstly identified that the synthetic LXR agonist T0901317 promoted IL-1β, IL-6 and TNFα mRNA degradation. Moreover, T0901317 destabilized TNFα mRNA through its 3'-untranslated region. In addition, T0901317 increased the expression of tristetraprolin (TTP), while antagonizing TTP with siRNA abrogated T0901317-mediated inflammatory cytokine mRNA decay...
January 23, 2017: Acta Biochimica et Biophysica Sinica
https://www.readbyqxmd.com/read/28119309/crp-and-fibrinogen-imply-clinical-outcome-of-patients-with-type-2-diabetes-and-coronary-artery-disease
#8
Marijan Bosevski, Golubinka Bosevska, Lily Stojanovska, Vasso Apostolopoulos
No abstract text is available yet for this article.
January 23, 2017: Acta Biochimica et Biophysica Sinica
https://www.readbyqxmd.com/read/28104582/amniotic-fluid-derived-stem-cells-mixed-with-platelet-rich-plasma-for-restoration-of-rat-alveolar-bone-defect
#9
Minjiao Wang, Hongliang Li, Jiawen Si, Jiewen Dai, Jun Shi, Xudong Wang, Lihe Guo, Guofang Shen
Stem cells isolated from the amniotic fluid have been shown as a promising candidate for cell therapy and tissue engineering. However, the experimental and preclinical applications of amniotic fluid-derived stem cells (AFSCs) in the very field of maxillofacial bone tissue engineering are still limited. In this study, rat AFSCs were successfully harvested and characterized in vitro The rat AFSCs showed typical fibroblastoid morphology, stable proliferation activity and multi-differentiation potential. Flow-cytometry analysis demonstrated that these cells were positive for CD29, CD44, and CD90, while negative for hematopoietic markers such as CD34 and CD45...
January 18, 2017: Acta Biochimica et Biophysica Sinica
https://www.readbyqxmd.com/read/28104581/high-glucose-stimulates-proliferation-and-inhibits-apoptosis-of-non-small-cell-lung-cancer-cells-by-jnk-mediated-downregulation-of-p53-pathway
#10
Lumei Wang, Nanzhe Zhong, Shujuan Liu, Xiaoyan Zhu, Yujian Liu
No abstract text is available yet for this article.
January 18, 2017: Acta Biochimica et Biophysica Sinica
https://www.readbyqxmd.com/read/28069586/sqle-induces-epithelial-to-mesenchymal-transition-by-regulating-of-mir-133b-in-esophageal-squamous-cell-carcinoma
#11
Yi Qin, Yi Zhang, Qinting Tang, Li Jin, Yong'an Chen
Increasing evidence suggests that microRNAs, which control gene expression at the post-transcriptional level, are aberrantly expressed in cancers and play significant roles in carcinogenesis and cancer progression. In this study, we show differential miR-133b down-expression in human esophageal squamous cell carcinoma (ESCC) cells and tissues. In addition, squalene epoxidase (SQLE), a key enzyme of cholesterol synthesis, is identified as the direct downstream target gene of miR-133b by luciferase gene reporter assay...
January 9, 2017: Acta Biochimica et Biophysica Sinica
https://www.readbyqxmd.com/read/28069585/expression-of-hmgb2-indicates-worse-survival-of-patients-and-is-required-for-the-maintenance-of-warburg-effect-in-pancreatic-cancer
#12
Xin Cai, Hongjian Ding, Yanxia Liu, Gaofeng Pan, Qingguo Li, Zhen Yang, Weiyan Liu
High mobility group proteins (HMGs) are the second most abundant chromatin proteins and exert global genomic functions in the establishment of active or inactive chromatin domains. Through interaction with nucleosomes, transcription factors, nucleosome-remodeling machines and histones, the HMGs family proteins contribute to the fine tuning of transcription in response to rapid environmental changes. Mammalian high mobility group Bs (HMGBs) are characterized by two tandem HMG box domains followed by a long acidic tail...
January 9, 2017: Acta Biochimica et Biophysica Sinica
https://www.readbyqxmd.com/read/28069584/role-of-norepinephrine-in-a%C3%AE-related-neurotoxicity-dual-interactions-with-tyr10-and-snk-26-28-of-a%C3%AE
#13
Mengmeng Liu, Liping Wan, Yannan Bin, Juan Xiang
With their capability to inhibit the formation of amyloid-β peptide (Aβ) fibril, norepinephrine (NE), and other catechol derivatives have been considered for the potential treatment of Alzheimer's disease (AD). Such treatment, however, remains debatable because of the diverse functions of Aβ and NE in AD pathology. Moreover, the complicated oxidation accompanying NE has caused the majority of the previous research to focus on the binding of NE oxides onto Aβ. The molecular mechanism by which Aβ interacts with the reduction state of NE, which is correlated with the brain function, should be urgently explored...
January 8, 2017: Acta Biochimica et Biophysica Sinica
https://www.readbyqxmd.com/read/28069583/mir-375-suppresses-invasion-and-metastasis-by-direct-targeting-of-shox2-in-esophageal-squamous-cell-carcinoma
#14
Jun Yi, Li Jin, Jing Chen, Bing Feng, Zhenyue He, Longbang Chen, Haizhu Song
Esophageal squamous cell carcinoma (ESCC) is the most common histological type in China. MicroRNAs are endogenously expressed in mammals and play a significant role in tumor invasion and metastasis by targeting potential downstream genes. In the present study, microarray analysis showed that miR-375 expression was distinctly downregulated in ESCC compared with that in normal esophageal epithelium tissues. Then, luciferase reporter assay showed that SHOX2 was the direct downstream target of miR-375 and this interaction was confirmed by the rescue experiments...
January 8, 2017: Acta Biochimica et Biophysica Sinica
https://www.readbyqxmd.com/read/28069582/human-apolipoprotein-a-i-exerts-a-prophylactic-effect-on-high-fat-diet-induced-atherosclerosis-via-inflammation-inhibition-in-a-rabbit-model
#15
Jiyang Li, Weina Wang, Lei Han, Meiqing Feng, Hui Lu, Li Yang, Xiangxiang Hu, Si Shi, Shanshan Jiang, Qian Wang, Li Ye
Apolipoprotein A-I (apoA-I) is the major functional protein fraction of high-density lipoprotein. The prophylactic effect and mechanism of human apoA-I on atherosclerosis (AS) were investigated in a high-fat diet-induced AS rabbit model. The rabbits were injected with apoA-I once a week while fed high-fat diet for 20 weeks. Our results showed that apoA-I could raise the serum level of high-density lipoprotein-cholesterol and reduce those of lipid total cholesterol, triglyceride, and low-density lipoprotein-cholesterol in AS rabbits...
January 8, 2017: Acta Biochimica et Biophysica Sinica
https://www.readbyqxmd.com/read/28040679/morphological-observation-rna-seq-quantification-and-expression-profiling-novel-insight-into-grafting-responsive-carotenoid-biosynthesis-in-watermelon-grafted-onto-pumpkin-rootstock
#16
Guang Liu, Xingping Yang, Jinhua Xu, Man Zhang, Qian Hou, Lingli Zhu, Ying Huang, Aisheng Xiong
Watermelon is an important and economical horticultural crop in China, where ~20% of the plants are grafted. The development of grafted watermelon fruit involves a diverse range of gene interactions that results in dynamic changes in fruit. However, the molecular mechanisms underlying grafting-induced fruit quality change are unclear. In the present study, we measured the lycopene content by high-performance liquid chromatography and used RNA-Seq (quantification) to perform a genome-wide transcript analysis of fruits from watermelon grafted onto pumpkin rootstock (pumpkin-grafted watermelon, PGW), self-grafted watermelon (SGW), and non-grafted watermelon (NGW)...
December 30, 2016: Acta Biochimica et Biophysica Sinica
https://www.readbyqxmd.com/read/28039150/the-effects-and-regulatory-mechanism-of-rip3-on-rgc-5-necroptosis-following-elevated-hydrostatic-pressure
#17
Lei Shang, Wei Ding, Na Li, Lvshuang Liao, Dan Chen, Jufang Huang, Kun Xiong
Necroptosis is a type of regulated cell death that has been implicated in various diseases. Receptor-interacting protein 3 (RIP3), a member of the RIP family, is an important mediator of the necroptotic pathway. Cleavage of RIP3 at Asp328 by caspase-8 abolishes the kinase activity of RIP3, which is critical for necroptosis. Moreover, RIP3 is significantly upregulated during the early stages of acute high intra-ocular pressure and oxygen glucose deprivation. In this study, the effects of RIP3 during elevated hydrostatic pressure (EHP) were investigated and the possible mechanism through which caspase-8 regulated RIP3 cleavage was explored...
December 29, 2016: Acta Biochimica et Biophysica Sinica
https://www.readbyqxmd.com/read/28039149/lysine-acetylation-regulates-the-activity-of-escherichia-coli-pyridoxine-5-phosphate-oxidase
#18
Jing Gu, Yuanyuan Chen, Hongsen Guo, Manluan Sun, Mingkun Yang, Xude Wang, Xian'en Zhang, Jiaoyu Deng
Nɛ-lysine acetylation is one of the most abundant post-translational modifications in eukaryote and prokaryote. Protein acetylome of Escherichia coli has been screened using mass spectrometry (MS) technology, and many acetylated proteins have been identified, including the pyridoxine 5'-phosphate oxidase (EcPNPOx), but the biological roles played by lysine acetylation in EcPNPOx still remain unknown. In this study, EcPNPOx was firstly overexpressed and purified, and two acetylated lysine residues were identified by the subsequent liquid chromatography-tandem mass spectrometry analysis...
December 29, 2016: Acta Biochimica et Biophysica Sinica
https://www.readbyqxmd.com/read/28039148/gpx1-knockdown-suppresses-chondrogenic-differentiation-of-atdc5-cells-through-induction-of-reductive-stress
#19
Jidong Yan, Yuanxu Guo, Yao Fei, Rui Zhang, Yan Han, Shemin Lu
Glutathione peroxidase 1 (GPx1) is a selenium (Se)-containing protein and is induced in cartilage formation. GPx1 eliminates reactive oxygen species (ROS), which are required for chondrogenic induction. The physiological properties of GPx1 in cartilage and the redox mechanisms involved are not known. The effects of GPx1 on chondrogenic differentiation of ATDC5 cells were examined through short hairpin RNA-mediated gene silencing. The results demonstrated that GPx1 knockdown impaired gene expression of sex determining region Y-box 9, collagen II (Col II), and aggrecan...
December 29, 2016: Acta Biochimica et Biophysica Sinica
https://www.readbyqxmd.com/read/28039147/incorporation-of-nlr-into-nih-stratification-system-increases-predictive-accuracy-for-surgically-resected-gastrointestinal-stromal-tumors
#20
Anwei Xue, Xiaodong Gao, Yong Fang, Ping Shu, Jiaqian Ling, Kuntang Shen, Yihong Sun, Jing Qin, Xinyu Qin, Yingyong Hou
Previous studies have reported that preoperative neutrophil-to-lymphocyte (NLR) and platelet-to-lymphocyte ratios were prognostic for various types of cancers. The aim of this study was to investigate the predictive utilities of preoperative peripheral blood counts in patients with gastrointestinal stromal tumors (GISTs). We enrolled 510 consecutive, previously untreated patients who underwent surgery for primary, localized GISTs. The relationship between recurrence-free survival and outcome variables was assessed by univariate and multivariate analyses, while the clinicopathologic relevance of NLR was determined using the Chi-square test...
December 29, 2016: Acta Biochimica et Biophysica Sinica
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