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Acta Biochimica et Biophysica Sinica

Le Chang, Xichen Zhang, Pengtao Gong, Yuru Wang, Boya Du, Jianhua Li
Toxoplasma gondii is an obligate intracellular protozoan that causes toxoplasmosis. Previous studies have shown that the perturbation of mitochondrial metabolism in T. gondii results in growth deficiency in host cells and lack of virulence in animals. Members of this Letm1 protein family are inner mitochondrial membrane proteins which play a role in potassium and hydrogen ion exchange. Letm1 has not been characterized in T. gondii. In this study, a potential TgLetm1 gene (TgGT1_288400) with Letm1-like protein domain coding sequence was identified in T...
November 13, 2018: Acta Biochimica et Biophysica Sinica
Chaosheng Zeng, Lin Chen, Bocan Chen, Yi Cai, Pengxiang Li, Limin Yan, Dehua Zeng
Anti-N-methyl-D-aspartate-receptor (NMDAR) encephalitis is an autoimmune disorder characterized by memory deficits, psychiatric symptoms, and autonomic instability. The lack of suitable biomarkers targeting anti-NMDAR encephalitis makes the immunotherapy and prognosis challenging. In this study, we found that the Th17 cells were significantly accumulated in the cerebrospinal fluid (CSF) of anti-NMDAR encephalitis patients than that of control individuals. The concentration of the cytokines and chemokines including interleukin (IL)-1β, IL-17, IL-6, and CXCL-13 were significantly increased in the CSF of anti-NMDAR encephalitis patients...
November 9, 2018: Acta Biochimica et Biophysica Sinica
Lingyan Ma, Qichen Shen, Song Yang, Xiaoxian Xie, Qingfeng Xiao, Chuanan Yu, Lisha Cao, Zhengwei Fu
Disrupted circadian rhythms are a recognized effect of depression, and our previous article demonstrated an association between depression and premature aging, but the underlying mechanisms are not well understood. In the present study, we used a mouse model of chronic corticosterone (CORT)-treated depression to elucidate a mechanism by which depression may be associated with the circadian clock and mediate age-related phenotypes. Mice received a daily injection of 20 mg/kg CORT for 21 consecutive days, and the depression-like behaviors of mice were identified by the sucrose intake test, tail suspension test and open field test...
November 5, 2018: Acta Biochimica et Biophysica Sinica
Boning Li, Shixia Bu, Junyan Sun, Ying Guo, Dongmei Lai
Epithelial ovarian cancer (EOC) is the most fatal gynecologic malignancy due to its late diagnosis and lack of curative therapy. The antimalaria compound artemisinin and its derivatives, such as artesunate (ART) and dihydroartemisinin (DHA), have proven to be potent anticancer drugs and act through various anticancer mechanisms. To identify novel targets of artemisinin derivatives in EOC cells, we investigated the effects of ART and DHA on SKOV3 and primary EOC cell growth via CCK-8 assay. Both ART and DHA inhibited EOC cell growth...
November 3, 2018: Acta Biochimica et Biophysica Sinica
Wuwen Zhang, Yunbin Zhang, Shifeng Li, Zhili Wu, Yuanchang Yan, Yiping Li
Epiboly spreads and thins the blastoderm over the yolk cell during zebrafish gastrulation. Despite of its fundamental function, little is known about the molecular mechanisms that control this coordinated cell movement. In this study, we investigated protein arginine methyltransferase 7 (Prmt7) morphants with an epibolic delay defect in zebrafish. The ratio of morphants with epiboly delay phenotypes increased as the dose of the injected morpholino (MO) increased. Here, syntenin transcripts are maternally deposited and ubiquitously expressed from the oocyte period to the early larva stage...
November 1, 2018: Acta Biochimica et Biophysica Sinica
Feng Zhong, Wei Zhang, Yang Cao, Qian Wen, Yue Cao, Bidan Lou, Jinxiang Li, Wenying Shi, Yinghan Liu, Rong Luo, Cheng Chen
Colorectal cancer (CRC) is the one of the most common malignant tumors worldwide. Recent years, widespread long non-coding RNAs (lncRNAs) have been discovered and are known to regulate gene expression in cancers. However, the roles and underlying mechanisms of lncRNA in CRC remain largely unclear. Here, we firstly revealed that repression of lncRNA nuclear paraspeckle assembly transcript 1 (NEAT1) inhibited cell proliferation and migration in HCT116 cells and overexpression of NEAT1 promoted cell proliferation and migration in SW480 cells using CCK8 assay and transwell assay...
November 1, 2018: Acta Biochimica et Biophysica Sinica
Wuqing Liu, Yunbin Zhang, Shifeng Li, Yiping Li
No abstract text is available yet for this article.
October 31, 2018: Acta Biochimica et Biophysica Sinica
Jiang Liu, Weiping Li, Weihua Zhu, Weimei He, Hui Zhao, Yu Xiang, Chunyan Liu, Wei Wu
The present study aims to characterize the effect of chronic intermittent hypoxia and HIF1α on the non-alcoholic steatohepatitis (NASH) process in mice, and to explore the role of the Treg/Th17 balance in the formation of NASH inflammation and fibrosis. To achieve this purpose, simple steatosis was induced in mice by high-fat diet administration. Subsequently, chronic intermittent hypoxia was simulated by intraperitoneally injecting sodium nitrite. The changes of inflammation, fibrosis, and Treg/Th17 balance in the liver were quantified under chronic intermittent hypoxia condition and after tail vein injection of HIF1α-siRNA...
October 31, 2018: Acta Biochimica et Biophysica Sinica
Xiaoyan Chen, Yan Du, Yiwen Liu, Yiqing He, Guoliang Zhang, Cuixia Yang, Feng Gao
In clinical breast cancer patients, quiescent disseminated tumor cells (DTCs) can persist for a long time in the bone marrow (BM) under the influence of microenvironmental cues. As a high molecular weight polysaccharide, hyaluronan (HA) not only has been shown to regulate cancer processes including cell invasion, metastasis, migration, and proliferation, but also is a major component of the BM extracellular matrix. Here, we tested whether HA promotes breast cancer cell quiescence through detecting cell proliferation, cell cycle phase distribution, and the expression of cell cycle-related regulator proteins...
October 29, 2018: Acta Biochimica et Biophysica Sinica
Li Ren, Lianyong Liu, Shuanggang Hu, Zhaohui Zhu, Hongling Zhu, Junhua Ma, Xuemei Zhao, Xing Wang, Chaobao Zhang, Mingjun Gu, Xiangqi Li
No abstract text is available yet for this article.
October 29, 2018: Acta Biochimica et Biophysica Sinica
Wuwen Zhang, Kai Li, Xiufang Zhong, Hua Yan, Guoqing Tong
Human in vitro fertilization (IVF) embryos usually have developmental block at 4-8 cell stages, in which only 30%-50% percent of IVF embryos develop to blastocyst stage. This is the main cause for low efficiency and repeated treatment failure in human fertility therapy. Transcription factor CDX2 is one of the key genes in human early embryonic development, which decides the differentiation from blastomere to trophoblastic lineage. However, the relationship between the developmental block of human IVF embryos and CDX2 is poorly understood...
October 29, 2018: Acta Biochimica et Biophysica Sinica
Jiao Cao, Pengyu Ma, Wenjing Xue, Yuanyuan Ding, Yongjing Zhang, Tao Zhang
No abstract text is available yet for this article.
October 29, 2018: Acta Biochimica et Biophysica Sinica
Lingli Wang, Ruirui Wang, Zi Ye, Yanyan Wang, Xiao Li, Weizhen Chen, Mengna Zhang, Cheguo Cai
Excessive adiposity has long been proved to be associated with greater incidence and mortality of breast cancer in post-menopausal women. However, the effects and underlying mechanisms of human adipocytes on breast cancer cells remain largely unknown. In recent years, several reports have revealed the oncogenic role of long non-coding RNA PVT1 in breast cancer. Here, we aimed to investigate the role and underlying mechanisms of PVT1 in triple-negative breast cancer (TNBC) cells cultured with mature adipogenic medium...
October 29, 2018: Acta Biochimica et Biophysica Sinica
Zhize Yuan, Lei Kang, Zhe Wang, Anqing Chen, Qiang Zhao, Haiqing Li
17β-estradiol (E2) has been shown to mediate endothelial progenitor cells (EPCs) to repair infarcted myocardium. Both estrogen receptor α (ERα) and stromal derived factor-1 (SDF-1)/CXCR4 signaling pathways may play a critical role in regulating homing and angiogenesis of EPCs in this process. However, the interaction between ERα and SDF-1/CXCR4 signaling pathways remains unclear. In response to E2, the expression of SDF-1 and CXCR4 in EPCs from ovariectomized BALB/C mice was obviously up-regulated, in addition, the migration and tube formation of EPCs in vitro were also significantly enhanced...
October 29, 2018: Acta Biochimica et Biophysica Sinica
Shenghe Huang, Qiang Fu, Feng Cheng, Yizhou Wan, Wenjun Quan, Chengyu Hu, Dongming Li
No abstract text is available yet for this article.
October 25, 2018: Acta Biochimica et Biophysica Sinica
Yanshen Li, Zhenhua Yu, Yong Cui, Hui Sun, Jin Li, Kun Yin, Guihua Zhao, Hongfa Wang, Bingcheng Huang, Qingkuan Wei, Gongzhen Liu, Jingxuan Kou
No abstract text is available yet for this article.
October 19, 2018: Acta Biochimica et Biophysica Sinica
Ping Luo, Jiayun Shao, Yingfu Jiao, Weifeng Yu, Weifang Rong
CC chemokine ligand 2 (CCL2) has been implicated in pathological pain, but the mechanism underlying the pronociceptive effect of CCL2 is not fully understood. Voltage-gated sodium (Nav) channels are important determinants of the excitability of sensory neurons. Hence we tested the hypothesis that CCL2 contributes to inflammatory pain via modulating Nav channel activity of primary afferent neurons. Chronic inflammatory pain was induced in rats by intraplantar injection of the complete Freud adjuvant (CFA) to one of the hind paws...
October 19, 2018: Acta Biochimica et Biophysica Sinica
Xu Zeng, Tiao Luo, Jijia Li, Gui Li, Donghua Zhou, Tuo Liu, Xian Zou, Aparna Pandey, Zhiyong Luo
Cytochromes P450 (CYP450s), a superfamily of mono-oxygenases, are essential to generate highly functionalized secondary metabolites in plants and contribute to the diversification of specialized triterpenoid biosynthesis in eudicots. However, screening and identifying the exact CYP450 genes in ginsenoside biosynthesis is extremely challenging due to existence of large quantities of members in CYP450 superfamily. Therefore, to screen the CYP450 genes involved in ginsenoside biosynthesis, transcriptome dataset of Panax ginseng was created in our previous work using the technique of the next-generation sequencing...
October 15, 2018: Acta Biochimica et Biophysica Sinica
Jinwen Su, Ming Fang, Bei Tian, Jun Luo, Can Jin, Xuejun Wang, Zhongping Ning, Xinming Li
Apoptosis is involved in the death of cardiac progenitor cells (CPCs) after myocardial infarction (MI) in the heart. The loss of CPCs results in infarct scar and further deterioration of the heart function. Though stem cell-based therapy provides an effective approach for heart function recovery after MI, the retention of CPCs in the infarcted area of the heart is the main barrier that limits its promising therapy. Therefore, the underlying mechanisms of CPC apoptosis in hypoxia are important for the development of new therapeutic targets for MI patients...
October 11, 2018: Acta Biochimica et Biophysica Sinica
Pengfei Hu, Yun Liang, Qiangsheng Hu, Hongwei Wang, Zhiwei Cai, Jiaqi He, Jianhua Cai, Meng Liu, Yi Qin, Xianjun Yu, Chongyi Jiang, Bo Zhang, Wei Wang
Pancreatic cancer remains a challenging disease with an overall cumulative 5-year survival rate around 6%. Though significant progress has been made in the availability of diagnostic techniques and treatment strategies, pancreatic cancer remains a disease of high mortality rate. Therefore, there is an urgent need for a better understanding of the molecular mechanisms that governs the oncogenesis and metastasis process of pancreatic cancer. In the present study, by using the Cancer Genome Atlas (TCGA) dataset analysis, we demonstrated that sorting nexin 6 (SNX6) serves as a biomarker for predicting prognosis of pancreatic cancer...
October 11, 2018: Acta Biochimica et Biophysica Sinica
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