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Acta Biochimica et Biophysica Sinica

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https://www.readbyqxmd.com/read/30239553/lncrna-hotair-mediates-tgf-%C3%AE-2-induced-cell-growth-and-epithelial-mesenchymal-transition-in-human-lens-epithelial-cells
#1
Zhilin Zhang, Huirong Zhu, Yan Liu, Fu Quan, Xibo Zhang, Ling Yu
Posterior capsule opacification (PCO) results from the proliferation, migration, and epithelial-mesenchymal transition (EMT) of residual lens epithelial cells (LECs) and fibers in the capsular bag. Previous reports have demonstrated that transforming growth factor β2 (TGF-β2) affects the cellular processes via modulation of EMT in LECs. However, the mechanisms that underlie the TGF-β2-induced EMT in LECs are still largely unknown. In this study, we confirmed that TGF-β2 induces EMT in SRA01/04 cells via the up-regulation of the long non-coding RNA (lncRNA) HOTAIR...
September 20, 2018: Acta Biochimica et Biophysica Sinica
https://www.readbyqxmd.com/read/30239560/lncrna-hotair-inhibition-aggravates-oxidative-stress-induced-h9c2-cells-injury-through-suppression-of-mmp2-by-mir-125
#2
Linlin Li, Mengna Zhang, Weizhen Chen, Ruirui Wang, Zi Ye, Yanyan Wang, Xiao Li, Cheguo Cai
Acute myocardial infarction (AMI) is one of the major causes of morbidity and mortality in the world. Ischemia/reperfusion (I/R) injury-induced cardiomyocytes death is the main obstacle that limits the heart function recovery of the AMI patients. Reactive oxygen species (ROS) generated by mitochondria is the main pathological stimulus of cardiomyocytes death during heart I/R injury process. Hence, to understand the underlying mechanism of cardioymocytes proliferation and apoptosis under oxidative stress is crucial for effective AMI therapy...
September 18, 2018: Acta Biochimica et Biophysica Sinica
https://www.readbyqxmd.com/read/30239551/cell-free-dna-derived-from-cancer-cells-facilitates-tumor-malignancy-through-toll-like-receptor-9-signaling-triggered-interleukin-8-secretion-in-colorectal-cancer
#3
Zhengchuan Niu, Wentao Tang, Tianyu Liu, Pingping Xu, Dexiang Zhu, Meiling Ji, Wenbai Huang, Li Ren, Ye Wei, Jianmin Xu
Circulating cell-free DNA (cfDNA) has become a potential diagnostic and prognostic biomarker for colorectal cancer (CRC). In non-cancerous diseases, it has been confirmed that cfDNA can be recognized by Toll-like receptor 9 (TLR9), leading to a significant biological change. Nevertheless, the biological significance of cfDNA and its relationship with TLR9 in tumor malignancy is still unclear. Therefore, the purpose of this study is to explore the biological role of cfDNA in colorectal cancer (CRC). The expression of TLR9 was measured in different CRC cell lines and cancerous samples by RT-PCR or immunohistochemistry, which showed that high expression of TLR9 was significantly correlated with the tumor metastasis, advanced TNM stage and poor prognosis of patients...
September 15, 2018: Acta Biochimica et Biophysica Sinica
https://www.readbyqxmd.com/read/30215665/the-role-of-rip3-in-cardiomyocyte-necrosis-induced-by-mitochondrial-damage-of-myocardial-ischemia-reperfusion
#4
Huifang Hou, Yongling Wang, Qiong Li, Zaibing Li, Yan Teng, Jingyu Li, Xiaoying Wang, Junli Chen, Ning Huang
Myocardial damage caused by myocardial ischemia-reperfusion injury (MIRI) is difficult to be alleviated because cardiomyocyte necrosis is an irreversible and unregulated death form. Recently, necroptosis, a necrosis form caused by tumor necrosis factor-α (TNF-α) and Fas ligand (FasL), was found to be regulated by receptor interacting protein 3 (RIP3) and RIP3-receptor interacting protein 1 (RIP1)-mixed lineage kinase domain like protein (MLKL) pathway. But it is unclear whether they also play a regulatory role in MIRI-induced necroptosis...
September 12, 2018: Acta Biochimica et Biophysica Sinica
https://www.readbyqxmd.com/read/30215664/mup-knockout-mice-generated-through-crispr-cas9-mediated-deletion-for-use-in-urinary-protein-analysis
#5
Haixia Yang, Wei Zhang, Shan Lu, Guangqing Lu, Hongjuan Zhang, Yinghua Zhuang, Yue Wang, Mengqiu Dong, Yu Zhang, Xingang Zhou, Peng Wang, Lei Yu, Fengchao Wang, Liang Chen
No abstract text is available yet for this article.
September 12, 2018: Acta Biochimica et Biophysica Sinica
https://www.readbyqxmd.com/read/30188967/fam198a-a-member-of-secreted-kinase-secrets-through-caveolae-biogenesis-pathway
#6
Zhuang Wei, Tao Liu, Jigang Lei, Yuan Wu, Shilong Wang, Kan Liao
Fam198a is a member of four-jointed protein kinases, a secreted protein kinase family. It was identified as a caveolae-associated protein and colocalized with cavin-1 and caveolin-1 in both tissues and cells. The newly synthesized Fam198a precursor in endoplasmic reticulum (ER) was transported by caveolae biogenesis vesicles to Golgi apparatus in which it was proteolytically cleaved into the secreted mature form. The amino acid mutation analysis identified Arg 120 and 437 as the proteolytic sites in Fam198a precursor during maturation...
September 5, 2018: Acta Biochimica et Biophysica Sinica
https://www.readbyqxmd.com/read/30188966/mir-23b-promotes-cutaneous-wound-healing-through-inhibition-of-the-inflammatory-responses-by-targeting-ask1
#7
Hongzhi Li, Xiao Han, Kuiyang Zuo, Li Li, Jieting Liu, Xiaohuan Yuan, Yongchao Shen, Minglong Shao, Daxin Pang, Yanhui Chu, Binghai Zhao
Wound healing is a complicated event that develops in three overlapping phases: inflammatory, proliferative, and remodeling. MicroRNAs (miRNAs) have been proved to play an important role in the healing process of skin trauma, and alteration of specific miRNA expression during different phases may be associated with abnormal wound healing. In this study, we determined the variation of miR-23b expression after trauma in normal mice and in cultured cells exposed to lipopolysaccharide. We further demonstrated that excessive miR-23b could significantly accelerate wound healing in vivo...
September 4, 2018: Acta Biochimica et Biophysica Sinica
https://www.readbyqxmd.com/read/30184089/insulin-like-growth-factor-1-receptor-signaling-regulates-embryonic-epicardial-cell-proliferation-through-focal-adhesion-kinase-pathway
#8
Yuling Yan, Qin Qin, Ling Wu, Xiaodong Jing, Songbai Deng, Qiang She
Embryonic epicardial cells (EPCs) can facilitate cardiomyocyte growth through secreting several essential growth factors, and participate in cardiac development through auto-differentiating into many cardiac cell lineages. Proper proliferation of EPCs is the precondition of these functions, so it is quite necessary to explore the mechanisms involving in EPC proliferation. In this study, we aimed to explore whether insulin-like growth factor 1 receptor (IGF1R) signaling participated in regulating the proliferation of EPCs...
August 31, 2018: Acta Biochimica et Biophysica Sinica
https://www.readbyqxmd.com/read/30165571/knockdown-of-lgals12-inhibits-porcine-adipocyte-adipogenesis-via-pka-erk1-2-signaling-pathway
#9
Wenjing Wu, Yajun Yin, Ke Xu, Yongjia Peng, Jin Zhang
Increasing intramuscular (IM) fat while concomitantly decreasing subcutaneous (SC) fat content is one major goal of pig breeding. Identifying genes involved in lipid metabolism is critical for this goal. Galectin-12 (LGALS12) has been proven to be an important regulator of fat deposition in mouse models; however, the effect and regulatory mechanisms of LGALS12 on porcine adipogenesis are still unknown. In this study, the effects of LGALS12 on fat deposition were explored with primary culture of porcine SC and IM adipocytes...
August 25, 2018: Acta Biochimica et Biophysica Sinica
https://www.readbyqxmd.com/read/30165534/tgf-%C3%AE-signaling-in-cancer
#10
Shuchen Gu, Xin-Hua Feng
Signals from the transforming growth factor-β (TGF-β) superfamily mediate a broad spectrum of cellular processes and are deregulated in many diseases, including cancer. TGF-β signaling has dual roles in tumorigenesis. In the early phase of tumorigenesis, TGF-β has tumor suppressive functions, primarily through cell cycle arrest and apoptosis. However, in the late stage of cancer, TGF-β acts as a driver of tumor progression and metastasis by increasing tumor cell invasiveness and migration and promoting chemo-resistance...
August 25, 2018: Acta Biochimica et Biophysica Sinica
https://www.readbyqxmd.com/read/30137289/altered-expressions-of-memory-genes-in-food-entrained-circadian-rhythm
#11
Yue Mei, Jianghong Zhang, Zhigang Li, Huajing Teng, Yan Wang, Zhongsheng Sun
No abstract text is available yet for this article.
August 22, 2018: Acta Biochimica et Biophysica Sinica
https://www.readbyqxmd.com/read/30137205/tafa-2-plays-an-essential-role-in-neuronal-survival-and-neurobiological-function-in-mice
#12
Xiyi Wang, Chunling Shen, Xuejiao Chen, Jinjin Wang, Xiaofang Cui, Yicheng Wang, Hongxin Zhang, Lingyun Tang, Shunyuan Lu, Jian Fei, Zhugang Wang
Tafa is a family of small secreted proteins with conserved cysteine residues and restricted expression in the brain. It is composed of five highly homologous genes referred to as Tafa-1 to -5. Among them, Tafa-2 is identified as one of the potential genes responsible for intellectual deficiency in a patient with mild mental retardation. To investigate the biological function of Tafa-2 in vivo, Tafa-2 knockout mice were generated. The mutant mice grew and developed normally but exhibited impairments in spatial learning and memory in Morris water maze test and impairments in short- and long-term memory in novel object recognition test, accompanied with increased level of anxiety-like behaviors in open-field test and elevated plus maze test, and decreased level of depression-like behaviors in forced-swim test and tail-suspension test...
August 22, 2018: Acta Biochimica et Biophysica Sinica
https://www.readbyqxmd.com/read/30137204/mitocpr-a-novel-protective-mechanism-in-response-to-mitochondrial-protein-import-stress
#13
Mingzhu Tang, Xuling Luo, Zhen Huang, Linxi Chen
No abstract text is available yet for this article.
August 22, 2018: Acta Biochimica et Biophysica Sinica
https://www.readbyqxmd.com/read/30137201/anti-leprosy-drug-clofazimine-binds-to-human-raf1-kinase-inhibitory-protein-and-enhances-erk-phosphorylation
#14
Chenyun Guo, Ting Chang, Tao Sun, Zhihua Wu, Yazhuang Dai, Hongwei Yao, Donghai Lin
Human Raf1 kinase inhibitory protein (hRKIP) is an important modulator of the Ras/Raf1/MEK/ERK signaling pathway. Here, we demonstrated that anti-leprosy drug Clofazimine can bind to hRKIP with a significantly stronger affinity than the endogenous substrate phosphatidylethanolamine (PE) by using Biolayer interference technology. Moreover, we identified that residues P74, S75, K80, P111, P112, V177, and P178 play crucial roles in the binding of hRKIP to Clofazimine by using a combination of Nuclear Magnetic Resonance spectroscopy and molecular docking approach...
August 22, 2018: Acta Biochimica et Biophysica Sinica
https://www.readbyqxmd.com/read/30137199/trail-armed-oncolytic-poxvirus-suppresses-lung-cancer-cell-by-inducing-apoptosis
#15
Jinqing Hu, Huaiyuan Wang, Jinfa Gu, Xinyuan Liu, Xiumei Zhou
Lung cancer has a high morbidity rate worldwide and is often resistant to therapy. Oncolytic virus therapy is a developing trend for cancer treatment. Thus, we constructed an oncolytic poxvirus carrying human trail gene that expresses a membrane-binding tumor necrosis factor and associated apoptosis-inducing ligand (TRAIL, Oncopox-trail). We hypothesized that the expression of trail would increase the efficacy of the oncolytic poxvirus. The effect of the TRAIL protein depends on the death receptors on the surface of different cancer cells...
August 22, 2018: Acta Biochimica et Biophysica Sinica
https://www.readbyqxmd.com/read/30137188/long-non-coding-rna-h19-contributes-to-hypoxia-induced-cpc-injury-by-suppressing-sirt1-through-mir-200a-3p
#16
Linlin Li, Qiuyun Wang, Zhize Yuan, Anqing Chen, Zuyun Liu, Haiqing Li, Zhe Wang
Cardiomyocytes death is the chief obstacle that prevents the heart function recovery in myocardial infarction (MI)-induced heart failure (HF). Cardiac progenitor cells (CPCs)-based myocardial regeneration has provided a promising method for heart function recovery after MI. However, CPCs can easily lose their proliferation ability due to oxygen deficiency in infarcted myocardium. Revealing the underlying molecular mechanism for CPC proliferation is critical for effective MI therapy. In the present study, we set up a CoCl2-induced hypoxia model in CPCs...
August 22, 2018: Acta Biochimica et Biophysica Sinica
https://www.readbyqxmd.com/read/30124739/anti-tumor-responses-to-hypofractionated-radiation-in-mice-grafted-with-triple-negative-breast-cancer-is-associated-with-decorin-induction-in-peritumoral-muscles
#17
Qi Yu, Kedao Xin, Yu Miao, Zhaobin Li, Shen Fu, Shudong Hu, Qing Zhang, Shumin Zhou
Triple negative breast cancer (TNBC) is the most lethal one for all types of breast cancer. Though radiotherapy is an efficient treatment, long-term survival rate of TNBC patients is still suboptimal. Hyprofractionated radiotherapy, an improved radiotherapy, has made an inspiring result in clinic. However, the mechanism underlying TNBC treated with hyprofractionated radiotherapy is not clear. Decorin (DCN) is a small poteoglycan of matrix which has an inhibitory effect on the breast cancer and is secreted by muscle under certain conditions...
August 14, 2018: Acta Biochimica et Biophysica Sinica
https://www.readbyqxmd.com/read/30084861/lc3-ii-may-mediate-atr-induced-mitophagy-in-dopaminergic-neurons-through-sqstm1-p62-pathway
#18
Kun Ma, Haoyu Wu, Peng Li, Baixiang Li
Atrazine (2-chloro-4-ethylamino-6-isopropylamine-1,3,5-triazine; ATR) has been demonstrated to regulate autophagy- and apoptosis-related proteins in doparminergic neuronal damage. In our study, we investigated the role of LC3-II in ATR-induced degeneration of dopaminergic neurons. In vivo dopaminergic neuron degeneration model was set up with ATR treatment and confirmed by the behavioral responses and pathological analysis. Dopaminergic neuron cells were transfected with LC3-II siRNA and treated with ATR to observe cell survival and reactive oxygen species release...
August 2, 2018: Acta Biochimica et Biophysica Sinica
https://www.readbyqxmd.com/read/30124738/circadian-locomotor-output-cycles-kaput-accelerates-atherosclerotic-plaque-formation-by-upregulating-plasminogen-activator-inhibitor-1-expression
#19
Qixia Jiang, Hua Liu, Shengyun Wang, Jiamei Wang, Yehua Tang, Zhiqing He, Feng Wu, Zhigang Huang, Xiaoliang Cong, Ru Ding, Chun Liang
To explore the association between clock circadian regulator circadian locomotor output cycles kaput gene (CLOCK) and the forming of atherosclerotic plaques and its underlying mechanisms, mouse aortic endothelial cells (MAECs) and atherosclerosis (AS) mouse model were recruited for our study. The apoE gene knockout mouse was used as the model of AS and we accelerated the formation of unstable plaques through the combination of carotid artery ligation and high-fat (HF) diet administration (0.2% cholesterol, 20% fat)...
September 1, 2018: Acta Biochimica et Biophysica Sinica
https://www.readbyqxmd.com/read/30060118/the-foxm1-abcc4-axis-mediates-carboplatin-resistance-in-human-retinoblastoma-y-79-cells
#20
Xue Zhu, Lidan Xue, Yong Yao, Ke Wang, Chengye Tan, Miao Zhuang, Fanfan Zhou, Ling Zhu
Carboplatin is the most commonly used drug in the first-line treatment of human retinoblastoma (RB), but its clinical application is greatly limited due to acquired drug resistance upon the long-term treatment. Forkhead box protein M1 (FoxM1) is the transcription factor aberrantly expressed in various types of human cancers, which plays an essential role in the regulation of tumorigenesis, tumor metastasis and drug resistance. However, little is known about the role of FoxM1 in chemo-resistance of human RB...
September 1, 2018: Acta Biochimica et Biophysica Sinica
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