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Esophagus: Official Journal of the Japan Esophageal Society

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https://www.readbyqxmd.com/read/29959634/prognostic-significance-of-high-serum-p53-antibody-titers-in-patients-with-esophageal-squamous-cell-carcinoma
#1
Takashi Suzuki, Satoshi Yajima, Nobuki Ishioka, Tatsuki Nanami, Yoko Oshima, Naohiro Washizawa, Kimihiko Funahashi, Seiko Otsuka, Tetsuo Nemoto, Hideaki Shimada
BACKGROUND: The p53 protein overexpression that usually results from genetic alterations reportedly induces serum antibodies against p53. However, little information is available about the prognostic significance of perioperative serum p53 antibody (s-p53-Abs) titers in patients with esophageal squamous cell carcinoma. METHODS: In this study, we retrospectively evaluated the clinical significance of perioperative s-p53-Abs in 135 patients with esophageal squamous cell carcinoma...
June 29, 2018: Esophagus: Official Journal of the Japan Esophageal Society
https://www.readbyqxmd.com/read/29936587/strategy-for-esophageal-non-epithelial-tumors-based-on-a-retrospective-analysis-of-a-single-facility
#2
Tomoaki Aoki, Tetsu Nakamura, Taro Oshikiri, Hiroshi Hasegawa, Masashi Yamamoto, Yoshiko Matsuda, Shingo Kanaji, Kimihiro Yamashita, Takeru Matsuda, Yasuo Sumi, Satoshi Suzuki, Yoshihiro Kakeji
BACKGROUND: Although most esophageal non-epithelial tumors are benign tumors, such as leiomyomas, they also include gastrointestinal tumors (GISTs); thus, a histopathological diagnosis is indispensable to determine the optimal treatment strategy. However, no consensus has been reached as to the diagnostic methods and treatments for esophageal non-epithelial tumors. The purpose of this study was to evaluate the reliability of the diagnostic methods and treatments for esophageal non-epithelial tumors in our hospital...
June 23, 2018: Esophagus: Official Journal of the Japan Esophageal Society
https://www.readbyqxmd.com/read/29923024/newly-developed-magnifying-endoscopic-classification-of-the-japan-esophageal-society-to-identify-superficial-barrett-s-esophagus-related-neoplasms
#3
Kenichi Goda, Junko Fujisaki, Ryu Ishihara, Manabu Takeuchi, Akiko Takahashi, Yasuhiro Takaki, Dai Hirasawa, Kumiko Momma, Yuji Amano, Kazuyoshi Yagi, Hiroto Furuhashi, Tomoki Shimizu, Takashi Kanesaka, Satoru Hashimoto, Yoichiro Ono, Taku Yamagata, Junko Fujiwara, Takane Azumi, Masako Nishikawa, Gen Watanabe, Yasuo Ohkura, Tsuneo Oyama
AIM AND METHODS: The Japan Esophageal Society created a working committee group consisting of 11 expert endoscopists and 2 pathologists with expertise in Barrett's esophagus (BE) and esophageal adenocarcinoma. The group developed a consensus-based classification for the diagnosis of superficial BE-related neoplasms using magnifying endoscopy. RESULTS: The classification has three characteristics: simplified, an easily understood classification by incorporating the diagnostic criteria for the early gastric cancer, including the white zone and demarcation line, and the presence of a modified flat pattern corresponding to non-dysplastic histology by adding novel diagnostic criteria...
June 19, 2018: Esophagus: Official Journal of the Japan Esophageal Society
https://www.readbyqxmd.com/read/29909488/histological-changes-of-superficial-esophageal-squamous-cell-carcinoma-after-preoperative-chemotherapy
#4
Takahito Sugase, Tomoki Makino, Makoto Yamasaki, Koji Tanaka, Tadayoshi Hashimoto, Yasuhiro Miyazaki, Tsuyoshi Takahashi, Yukinori Kurokawa, Kiyokazu Nakajima, Masayuki Mano, Eiichi Morii, Masaki Mori, Yuichiro Doki
INTRODUCTION: We aimed to analyze the clinical and histological effects of chemotherapy in superficial esophageal squamous cell carcinoma (SESCC). METHODS: We analyzed tumor samples from five patients with cT1bN1M0 who underwent subtotal esophagectomy following two courses of a new triplet chemotherapy regimen including docetaxel, cisplatin, and 5-fluorouracil (DCF). To assess the histological effects of chemotherapy, resected specimens were analyzed by macroscopic examination, hematoxylin & eosin (HE) staining, immunohistochemical (IHC) staining (p53, Ki-67 and cytokeratin) and periodic acid-Schiff (PAS) staining...
June 16, 2018: Esophagus: Official Journal of the Japan Esophageal Society
https://www.readbyqxmd.com/read/29948480/definitive-chemoradiotherapy-with-docetaxel-cisplatin-and-5-fluorouracil-dcf-r-for-advanced-cervical-esophageal-cancer
#5
Hiroshi Okamoto, Yusuke Taniyama, Tadashi Sakurai, Takahiro Heishi, Jin Teshima, Chiaki Sato, Shota Maruyama, Ken Ito, Yu Onodera, Takuro Konno-Kumagai, Hirotaka Ishida, Takashi Kamei
BACKGROUND: Recently, definitive chemoradiotherapy (dCRT) has become one of the essential treatment strategies for esophageal squamous cell carcinoma (ESCC) and has been especially gaining prevalence for cervical ESCC to preserve the larynx. Our department recently introduced dCRT concomitant with docetaxel, cisplatin, and 5-fluorouracil (DCF-R) for treating advanced cervical ESCC. This study aims to assess the safety and outcomes of DCF-R in patients with advanced cervical ESCC. METHODS: We retrospectively assessed 11 patients with advanced cervical ESCC (clinical stage: II-IV, including T4b and/or M1 lymph node) who received DCF-R as the first-line treatment between December 2010 and February 2015...
June 15, 2018: Esophagus: Official Journal of the Japan Esophageal Society
https://www.readbyqxmd.com/read/29948479/histological-study-of-the-thin-membranous-structure-made-of-dense-connective-tissue-around-the-esophagus-in-the-upper-mediastinum
#6
Yutaka Tokairin, Yasuaki Nakajima, Kenro Kawada, Akihiro Hoshino, Takuya Okada, Tairo Ryotokuji, Masafumi Okuda, Yuichiro Kume, Yudai Kawamura, Kazuya Yamaguchi, Kagami Nagai, Keiichi Akita, Yusuke Kinugasa
BACKGROUND: The structure of the fascia in upper mediastinum has already been reported from gross anatomical viewpoints by Sarrazin. But it is necessary to understand meticulous anatomy for thoracoscopic or mediastinoscopic surgery. So herein, we investigate histologically the thin membranous structure made of dense connective tissues. METHODS: Semi-sequential transverse sections of the mediastinum were obtained from three cadavers. Hematoxylin and eosin staining, Elastica van Gieson staining, and Masson trichrome staining were performed to identify the presence and location of the thin membranous structure made of dense connective tissues...
June 13, 2018: Esophagus: Official Journal of the Japan Esophageal Society
https://www.readbyqxmd.com/read/29948478/correction-to-comprehensive-registry-of-esophageal-cancer-in-japan-2011
#7
Yuji Tachimori, Soji Ozawa, Hodaka Numasaki, Ryu Ishihara, Hisahiro Matsubara, Kei Muro, Tsuneo Oyama, Yasushi Toh, Harushi Udagawa, Takashi Uno
In the original publication of the article, the below name of institutions were not included in the table of Institution-registered cases in 2011.
June 12, 2018: Esophagus: Official Journal of the Japan Esophageal Society
https://www.readbyqxmd.com/read/29951987/recent-progress-in-perioperative-management-of-patients-undergoing-esophagectomy-for-esophageal-cancer
#8
Masayuki Watanabe, Akihiko Okamura, Tasuku Toihata, Kotaro Yamashita, Masami Yuda, Masaru Hayami, Ian Fukudome, Yu Imamura, Shinji Mine
Esophagectomy remains the mainstay of curative intent treatment for esophageal cancer. Oncologic esophagectomy is a highly invasive surgery and both morbidity and mortality rates still remain high. Recently, it has been revealed that multidisciplinary perioperative management can decrease the postoperative complications after esophagectomy. In this review, we summarized the recent progress in each component of multidisciplinary perioperative care bundle, including oral hygiene, cessation of smoking and alcohol, respiratory training, measurement of physical fitness, swallowing evaluation and rehabilitation, nutritional support, pain control and management of delirium...
July 2018: Esophagus: Official Journal of the Japan Esophageal Society
https://www.readbyqxmd.com/read/29951986/reply-to-preventive-role-of-ramelteon-and-suvorexant-for-postoperative-delirium-after-pharyngolaryngectomy-with-esophagectomy
#9
LETTER
Eisuke Booka, Yasuhiro Tsubosa, Teruaki Matsumoto, Mari Takeuchi, Takashi Kitani, Masato Nagaoka, Atsushi Imai, Tomoyuki Kamijo, Yoshiyuki Iida, Ayako Shimada, Katsushi Takebayashi, Masahiro Niihara, Keita Mori, Tetsuro Onitsuka, Hiroya Takeuchi, Yuko Kitagawa
No abstract text is available yet for this article.
July 2018: Esophagus: Official Journal of the Japan Esophageal Society
https://www.readbyqxmd.com/read/29951985/clinical-characteristics-and-management-of-gastric-tube-cancer-after-esophagectomy
#10
Yasuhiro Shirakawa, Kazuhiro Noma, Naoaki Maeda, Takayuki Ninomiya, Shunsuke Tanabe, Satoru Kikuchi, Shinji Kuroda, Masahiko Nishizaki, Shunsuke Kagawa, Yoshiro Kawahara, Hiroyuki Okada, Toshiyoshi Fujiwara
BACKGROUND: Gastric cancer is the second most common malignancy, overlapping with thoracic esophageal cancer (TEC). Among them, metachronous gastric tube cancers after TEC surgery have been increasing. The aims of this study were to examine the clinicopathological factors and treatment outcomes of gastric tube cancer (GTC) after TEC surgery. METHODS: Thirty-three GTCs in 30 cases after TEC treated between 1997 and 2016 were investigated retrospectively. RESULTS: Most cases were males...
July 2018: Esophagus: Official Journal of the Japan Esophageal Society
https://www.readbyqxmd.com/read/29951984/impact-of-change-in-serum-albumin-level-during-and-after-chemoradiotherapy-in-patients-with-locally-advanced-esophageal-cancer
#11
Kazuya Takeda, Rei Umezawa, Noriyoshi Takahashi, Haruo Matsushita, Maiko Kozumi, Yojiro Ishikawa, Takaya Yamamoto, Ken Takeda, Keiichi Jingu
BACKGROUND: In patients with locally advanced esophageal cancer treated by concurrent chemoradiotherapy (CCRT), baseline malnutrition and its progression have been shown to be associated with a poor outcome. We conducted this study to determine the variation in four blood test parameters including serum albumin level (ALB), creatinine (Cre), hemoglobin (Hb) and platelet (Plt) during CCRT for stage III esophageal cancer patients and its effect on patients' outcome. METHODS: One hundred eighty-three patients diagnosed with stage III esophageal cancer were retrospectively investigated...
July 2018: Esophagus: Official Journal of the Japan Esophageal Society
https://www.readbyqxmd.com/read/29951983/the-effect-of-platelet-rich-plasma-on-motility-changes-in-experimental-caustic-esophageal-burn
#12
Mustafa Onur Oztan, Sule Oztan, Neslihan Duzenli, Murat Olukman, Gokhan Koyluoglu
BACKGROUND: Besides stricture formation, diminished esophageal motility after caustic esophageal burns also plays a role in the deterioration of the clinical course. In this study, we aimed to investigate the effect of caustic burn on the esophageal contractions and the effect of platelet-rich plasma (PRP) on these changes. METHODS: Twenty-one Wistar albino rats were divided into three groups [Sham operation (n = 8), caustic esophageal burn with NaOH (n = 6), PRP treatment after caustic burn (n = 7)]...
July 2018: Esophagus: Official Journal of the Japan Esophageal Society
https://www.readbyqxmd.com/read/29951982/mediastinoscopic-view-of-the-bronchial-arteries-in-a-series-of-surgical-cases-evaluated-with-three-dimensional-computed-tomography
#13
Kazuhiko Mori, Kenji Ino, Shuntaro Yoshimura, Susumu Aikou, Koichi Yagi, Masato Nishida, Takashi Mitsui, Yasuhiro Okumura, Yukinori Yamagata, Hiroharu Yamashita, Sachiyo Nomura, Yasuyuki Seto
BACKGROUND: We have routinely performed three-dimensional computed tomography (3-D CT) prior to video-assisted transmediastinal esophagectomy to evaluate the small arteries in the mediastinal operative field. This evaluation would be helpful in performing mediastinoscopic esophagectomy. METHODS: Thirty-one patients who underwent transmediastinal esophagectomy with preoperative evaluations by 3-D CT were the study subject. The bronchial arteries depicted by the 3-D CT were classified by their origin and laterality...
July 2018: Esophagus: Official Journal of the Japan Esophageal Society
https://www.readbyqxmd.com/read/29951981/immediate-extubation-after-esophagectomy-with-three-field-lymphadenectomy-enables-early-ambulation-in-patients-with-thoracic-esophageal-cancer
#14
Takeharu Imai, Tetsuya Abe, Norihisa Uemura, Kazuhiro Yoshida, Yasuhiro Shimizu
BACKGROUND: We retrospectively compared the effects of immediate extubation (IE) in the operating room with those of overnight mechanical ventilation (MV) after radical transthoracic esophagectomy with 3-field lymphadenectomy in patients with thoracic esophageal cancer. METHODS: A total of 96 patients were evaluated. 48 patients were extubated in the operating room after surgery (IE group). The other 48 patients were extubated on the following morning (MV group)...
July 2018: Esophagus: Official Journal of the Japan Esophageal Society
https://www.readbyqxmd.com/read/29951980/preventive-role-of-ramelteon-and-suvorexant-for-postoperative-delirium-after-pharyngolaryngectomy-with-esophagectomy
#15
LETTER
Tomoyuki Kawada
No abstract text is available yet for this article.
July 2018: Esophagus: Official Journal of the Japan Esophageal Society
https://www.readbyqxmd.com/read/29948477/comprehensive-registry-of-esophageal-cancer-in-japan-2011
#16
Yuji Tachimori, Soji Ozawa, Hodaka Numasaki, Ryu Ishihara, Hisahiro Matsubara, Kei Muro, Tsuneo Oyama, Yasushi Toh, Harushi Udagawa, Takashi Uno
No abstract text is available yet for this article.
July 2018: Esophagus: Official Journal of the Japan Esophageal Society
https://www.readbyqxmd.com/read/29892938/cricopharyngeal-myotomy-with-flexible-endoscope-for-zenker-s-diverticulum-using-hook-knife-and-endoclips-with-video-describing-an-objective-measurement-of-the-cutting-length
#17
Francesco Pugliese, Lorenzo Dioscoridi, Antonello Forgione, Edoardo Forti, Marcello Cintolo, Massimiliano Mutignani
Cricopharyngeal myotomy with flexible endoscope is a well-known and safe treatment for Zenker's diverticulum. We describe hereafter how we perform this flexible endotherapy. From January 2011 to January 2017, we treated 28 patients with this endotherapy. Our technique is described step-by-step in the paper: the main principle is to perform an endoscopic cut of the diverticular septum and cricopharyngeal muscle's fibers (see the video). We describe an objective measurement of the cutting length and depth of the myotomy...
April 2018: Esophagus: Official Journal of the Japan Esophageal Society
https://www.readbyqxmd.com/read/29892937/surgical-team-proficiency-in-minimally-invasive-esophagectomy-is-related-to-case-volume-and-improves-patient-outcomes
#18
Akihiko Okamura, Masayuki Watanabe, Ian Fukudome, Kotaro Yamashita, Masami Yuda, Masaru Hayami, Yu Imamura, Shinji Mine
BACKGROUND: Minimally invasive esophagectomy (MIE) is being increasingly performed; however, it is still associated with high morbidity and mortality. The correlation between surgical team proficiency and patient load lacks clarity. This study evaluates surgical outcomes during the first 3-year period after establishment of a new surgical team. METHODS: A new surgical team was established in September 2013 by two expert surgeons having experience of performing more than 100 MIEs...
April 2018: Esophagus: Official Journal of the Japan Esophageal Society
https://www.readbyqxmd.com/read/29892936/treatment-selection-for-esophageal-cancer-evaluation-from-a-nationwide-database
#19
Yasuo Hamamoto, Naoki Sakakibara, Fumio Nagashima, Yuko Kitagawa, Takahiro Higashi
BACKGROUND: Most elderly patients poorly tolerate the standard treatment for esophageal cancer; however, little information is available regarding the appropriateness of non-standard esophageal cancer treatments for those patients. This study aims to analyze the treatment costs and completion rates of patients undergoing a real-world treatment for esophageal cancer to elucidate the treatment selection and its quality. MATERIALS AND METHODS: We analyzed treatment costs and completion rates for patients with esophageal cancer and analyzed these data relative to patient age and center volumes...
April 2018: Esophagus: Official Journal of the Japan Esophageal Society
https://www.readbyqxmd.com/read/29892935/the-concentration-of-programmed-cell-death-ligand-1-in-the-peripheral-blood-is-a-useful-biomarker-for-esophageal-squamous-cell-carcinoma
#20
Yasunori Akutsu, Kentaro Murakami, Masayuki Kano, Takeshi Toyozumi, Yasunori Matsumoto, Masahiko Takahashi, Ryota Otsuka, Nobufumi Sekino, Masaya Yokoyama, Tadashi Shiraishi, Hisahiro Matsubara
BACKGROUND: We determined the serum concentrations of Programmed cell death-1 (PD-1) and its ligands (PD-L1 and PD-L2) in patients with esophageal squamous cell carcinoma (ESCC). METHODS: Blood samples were collected from 85 patients with histologically proved ESCC. Serum levels of PD-1, PD-L1, and PD-L2 were measured using enzyme linked immunosorbent assays. Correlations between serum PD-1, PD-L1, and PD-L2 concentration and tumor depth, number of lymph node metastases, organ metastasis status, or disease stage were assessed and five-year survival rates according to clinicopathological characteristics were calculated...
April 2018: Esophagus: Official Journal of the Japan Esophageal Society
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