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Pediatric Endocrinology Reviews: PER

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https://www.readbyqxmd.com/read/28613050/meeting-reports-2016-annual-meeting-of-the-sociedad-latinoamericana-de-endocrinolog%C3%A3-a-pedi%C3%A3-trica-slep-buenos-aires-argentina-november-8-11-2016-selected-highlights
#1
Romina Grinspon, Débora Braslavsky, Ana Chiesa, Patricia Papendieck, Patricia Pennisi, Florencia Clement, Ana Vieites, Ana Keselman, Mirta Gryngarten, Analía Freire, María Gabriela Ballerini, Rodolfo Rey, Ignacio Bergadá, Horacio Domené
No abstract text is available yet for this article.
June 2017: Pediatric Endocrinology Reviews: PER
https://www.readbyqxmd.com/read/28613049/meeting-reports-the-eight-international-congress-of-the-grs-and-igf-society-tel-aviv-november-6-9-2016
#2
Haim Werner
No abstract text is available yet for this article.
June 2017: Pediatric Endocrinology Reviews: PER
https://www.readbyqxmd.com/read/28613048/is-the-second-to-fourth-digit-ratio-2d-4d-a-biomarker-of-sex-steroids-activity
#3
Vincenzo de Sanctis, Ashraf T Soliman, Heba Elsedfy, Nada Soliman, Rania Elalaily, Salvatore Di Maio
The second-to-fourth digit ratio (2D:4D) has been used as an indirect method to investigate the putative effects of prenatal exposure to androgens, and has been reported to be smaller in males than in females. This gender difference in digit length ratios has been linked with the in utero balance of androgens to oestrogen. This sexual dimorphism in 2D:4D ratios is apparent by 2 years of age and seems to be established early in life, possibly by the 14th week of gestation. Digits in females attain their maximum length at about 2...
June 2017: Pediatric Endocrinology Reviews: PER
https://www.readbyqxmd.com/read/28613047/adolescent-gynecomastia
#4
Carly E Guss, Amy D Divasta
Gynecomastia, defined as the presence of glandular breast tissue in men, is a common, typically benign physical exam finding during adolescence. Although the exact pathogenesis of gynecomastia is unknown, it is likely due to a hormonal imbalance between estrogens and androgens. Most cases are idiopathic and do not require further evaluation if the history and physical examination are reassuring. Although the majority of cases will resolve spontaneously, surgical correction may be an option for adolescents with persistent and problematic gynecomastia...
June 2017: Pediatric Endocrinology Reviews: PER
https://www.readbyqxmd.com/read/28613046/anti-mullerian-hormone-amh-determinations-in-the-pediatric-and-adolescent-endocrine-practice
#5
Amir Weintraub, Talia Eldar-Geva
Anti-Mullerian hormone (AMH), secreted by immature testicular Sertoli-cells, triggers the regression of male fetal Mullerian ducts. During puberty, AMH is downregulated by intratesticular testosterone. In females, AMH is secreted from granulosa cells of immature ovarian follicles from late prenatal life until menopause; serum concentration is 5-20 times lower in females than in males through lifetime. In boys, AMH determination is useful in the clinical setting as a marker of Sertoli cell function. Serum AMH is low in infants with hypogonadotrophic hypogonadism (and increases with FSH treatment), in patients with primary hypogonadism from early postnatal life and in Klinefelter syndrome from midpuberty...
June 2017: Pediatric Endocrinology Reviews: PER
https://www.readbyqxmd.com/read/28613045/therapeutic-genome-editing-and-its-potential-enhancement-through-crispr-guide-rna-and-cas9-modifications
#6
Nurit Assia Batzir, Adi Tovin, Ayal Hendel
Genome editing with engineered nucleases is a rapidly growing field thanks to transformative technologies that allow researchers to precisely alter genomes for numerous applications including basic research, biotechnology, and human gene therapy. The genome editing process relies on creating a site-specific DNA double-strand break (DSB) by engineered nucleases and then allowing the cell's repair machinery to repair the break such that precise changes are made to the DNA sequence. The recent development of CRISPR-Cas systems as easily accessible and programmable tools for genome editing accelerates the progress towards using genome editing as a new approach to human therapeutics...
June 2017: Pediatric Endocrinology Reviews: PER
https://www.readbyqxmd.com/read/28613044/for-debate-should-bariatric-surgery-be-performed-in-children-and-adolescents-with-hypothalamic-obesity
#7
EDITORIAL
Sarka Stolbova, Marek Benes, Lenka Petruzelkova, Jan Lebl, Stanislava Kolouskova
Hypothalamic dysfunction leading to severe obesity is a serious long-term consequence of paediatric craniopharyngioma. It compromises quality of life, leads to long-term metabolic hazards, and may shorten life expectancy. Therefore, a proactive approach is required. Conventional treatment of hypothalamic obesity is difficult and hardly successful. Experience with bariatric surgery is limited, especially in younger patients. Two retrospective studies recently reported on classic bariatric surgery in a small series of individuals after craniopharyngioma...
June 2017: Pediatric Endocrinology Reviews: PER
https://www.readbyqxmd.com/read/28613043/worth-remembering-andries-querido-md-1912-2001-the-father-of-clinical-endocrinology-in-the-netherlands
#8
EDITORIAL
Henk Ka Visser
No abstract text is available yet for this article.
June 2017: Pediatric Endocrinology Reviews: PER
https://www.readbyqxmd.com/read/28516755/iodine-and-thyroid-function-a-historical-review-of-goiter-and-the-current-iodine-status-in-japan
#9
Yozen Fuse
No abstract text is available yet for this article.
March 2017: Pediatric Endocrinology Reviews: PER
https://www.readbyqxmd.com/read/28516754/adult-height-in-patients-with-turner-syndrome-and-association-with-lifestyle-related-diseases-after-human-growth-hormone-treatment-in-japan
#10
Kunihiko Hanew, Toshiaki Tanaka
No abstract text is available yet for this article.
March 2017: Pediatric Endocrinology Reviews: PER
https://www.readbyqxmd.com/read/28516753/revision-of-the-growth-references-for-japanese-girls-with-turner-syndrome
#11
Tsuyoshi Isojima
No abstract text is available yet for this article.
March 2017: Pediatric Endocrinology Reviews: PER
https://www.readbyqxmd.com/read/28516752/growth-hormone-treatment-and-adverse-events
#12
Yoshikazu Nishi, Toshiaki Tanaka
We compiled the major adverse events included in the Annual Research Reports of the Foundation for Growth Research published in and after 2000. We conducted a review of approximately 32,000 patients treated with growth hormone (GH) who subsequently developed leukemia and who were registered with the Foundation for Growth Research (from 1975 to December 31 1997). We performed a literature review and found that GH therapy was not associated with leukemia onset in patients with no risk factors for leukemia. We also reported the onset of diabetes mellitus (DM), scoliosis, and respiratory problems in patients with Prader-Willi syndrome who were treated with GH...
March 2017: Pediatric Endocrinology Reviews: PER
https://www.readbyqxmd.com/read/28516751/growth-hormone-therapy-and-brain-tumors
#13
Akira Teramoto
As one of the projects of the Adverse Events Study Group of the Foundation for Growth Science in Japan, the literatures on the recurrence and / or regrowth or new formation of brain tumors in patients treated with growth hormone (GH) were reviewed. Since the tumor volume of the sellar lesion can be accurately evaluated only by magnetic resonance imaging (MRI), the related literatures published after 1990 were retrieved by searching under keywords, such as GH, replacement therapy, brain tumor, recurrence, tumor formation, etc...
March 2017: Pediatric Endocrinology Reviews: PER
https://www.readbyqxmd.com/read/28516750/quality-of-life-of-sga-children-with-short-stature-receiving-gh-treatment-in-japan
#14
Ryo Takahashi, Madoka Ogawa, Hisao Osada
The objective of this study was to compare the quality of life (QOL) of small for gestational age (SGA) children with short stature with that of children with normal height, and examine the effects of growth hormone (GH) treatment on the QOL of the SGA children using questionnaires administered to their parents or guardians. The results showed that QOL in daily living of SGA children with short stature was lower than that of normal children based on the perceptions of their parents or guardians. In addition, GH treatment improved the physical domain of QOL of SGA children with short stature...
March 2017: Pediatric Endocrinology Reviews: PER
https://www.readbyqxmd.com/read/28516749/international-comparison-of-adult-height-in-children-with-growth-hormone-deficiency-and-limitations-of-growth-hormone-treatment-in-japan
#15
Toshiaki Tanaka
The approved therapeutic dose of growth hormone (GH) for growth hormone deficiency (GHD) varies depending on the country. Japan has the lowest therapeutic dose globally, with a single dose of 0.175 mg/kg/week. GH treatment for GHD is considered as a replacement therapy and in fact, a dose of 0.175 mg/kg/week is slightly higher than GH secretion in prepubertal healthy children but nearly the same as that of pubertal children. Although the same growth rate as that of healthy children is expected in response to replacement therapy, the catch-up growth observed for the first 1 to 2 years of GH treatment was misinterpreted as an effect of the GH replacement therapy...
March 2017: Pediatric Endocrinology Reviews: PER
https://www.readbyqxmd.com/read/28516748/standardization-of-growth-hormone-and-insulin-like-growth-factor-i-measurements
#16
Noriyuki Katsumata
Measurement of the levels of growth hormone (GH) and its related factor insulin-like growth factor I (IGF-I) is essential for the diagnosis and treatment of GH deficiency (GHD) and conditions related to excess GH such as acromegaly and pituitary gigantism. Measurement of GH levels is also used as an indicator of hypothalamic-pituitary function. Because of the marked variability in GH measurements among kits, the Study Committee for GH and Its Related Factors of The Foundation for Growth Science, Japan standardized GH values measured with various commercially available GH assay kits in Japan...
March 2017: Pediatric Endocrinology Reviews: PER
https://www.readbyqxmd.com/read/28516747/the-history-of-growth-hormone-treatment-for-ghd-in-japan
#17
Susumu Yokoya, Toshiaki Tanaka
In Japan, treatment of growth hormone deficiency with pituitary-extracted human growth hormone (phGH) was covered by health insurance for the first time in 1975. However, because of the shortage of phGH, the Foundation for Growth Science (FGS) was founded in 1977 to control the use of the product by its registration system and to collect pituitary glands in Japan. In 1986, recombinant human growth hormone was first approved. Since then, the FGS has been involved in the harmonization of growth hormone measurement, assessment for treatment eligibility according to the diagnostic criteria by the research group of the Ministry of Health and Welfare, and database generation and its utilization...
March 2017: Pediatric Endocrinology Reviews: PER
https://www.readbyqxmd.com/read/28508603/meeting-reports-adolescence-a-transition-to-adulthood-proceedings-of-the-24th-aschauer-soiree-held-at-jurata-poland-november-5th-2016
#18
Slawomir Koziel, Michael Hermanussen, Alexandra Gomula, James Swanson, Maria Kaczmarek, Mortada El-Shabrawi, Mona Elhusseini, Takashi Satake, Irena Klarić Martinović, Christiane Scheffler, Ruta Morkuniene, Elena Godina, Missoni Saša, Tutkuviene Janina, Siniarska Anna, Joanna Nieczuja-Dwojacka, Javier Núñez, Detlef Groth, Davide Barbieri
No abstract text is available yet for this article.
March 2017: Pediatric Endocrinology Reviews: PER
https://www.readbyqxmd.com/read/28508602/succinate-dehydrogenase-deficient-paragangliomas-pheochromocytomas-genetics-clinical-aspects-and-mini-review
#19
Larisa Rusyn, Brenda Kohn
No abstract text is available yet for this article.
March 2017: Pediatric Endocrinology Reviews: PER
https://www.readbyqxmd.com/read/28508601/effects-of-anorexia-nervosa-on-the-endocrine-system
#20
Charumathi Baskaran, Madhusmita Misra, Anne Klibanski
Anorexia nervosa (AN) is characterized by severe undernutrition associated with alterations in multiple endocrine axes, which are primarily adaptive to the state of caloric deprivation. Hormonal changes include growth hormone (GH) resistance with low insulin like growth factor-1 (IGF-1) levels, hypothalamic hypogonadism, relative hypercortisolemia and changes in appetite regulating hormones, including leptin, ghrelin, and peptide YY. These alterations contribute to abnormalities in bone metabolism leading to low bone mass, impaired bone microarchitecture, and increased risk for fracture, and may also negatively impact cognition, emotions and mood...
March 2017: Pediatric Endocrinology Reviews: PER
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