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Journal of Immunotoxicology

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https://www.readbyqxmd.com/read/29973080/methoxychlor-metabolite-hpte-alters-viability-and-differentiation-of-embryonic-thymocytes-from-c57bl-6-mice
#1
Lucie Leung-Gurung, Priscilla Escalante Cobb, Faraj Mourad, Cristina Zambrano, Zachary Muscato, Victoria Sanchez, Kanya Godde, Christine Broussard
Endocrine-disrupting chemicals (EDC) are widespread in the built and natural environments. Heightened public awareness of their potential danger has led to concern about whether EDC and their metabolites have significant negative biological effects. Studies have shown that EDC like DDT and other organochlorine pesticides, such as methoxychlor (MXC), have adverse effects on immune cells, but no studies have addressed the impact of HPTE, the primary metabolite of MXC. To elucidate the presence and significance of HPTE adverse effects, this study explored the impact of HPTE on a critical window and component of immune system development, embryonic T-cell development...
December 2018: Journal of Immunotoxicology
https://www.readbyqxmd.com/read/29847185/modulation-of-cytokine-chemokine-production-in-human-macrophages-by-bisphenol-a-a-comparison-to-analogues-and-interactions-with-genistein
#2
Yingjia Chen, Hannah Shibo Xu, Tai L Guo
The immunotoxicant bisphenol A (BPA) may produce toxic effects on organs and systems, in part, by altering the secretion of cytokines and chemokines. However, systematic studies of the effects of BPA, let alone of its analogs and in cases when there are interactions with other chemicals, on innate immunity and cytokine modulation are limited. The objectives of this study were to investigate the immunomodulatory effects of: (1) BPA and its analogs, BPS and BPAF; and (2) the interaction between BPA and genistein (GEN), a partial estrogen agonist or antagonist...
December 2018: Journal of Immunotoxicology
https://www.readbyqxmd.com/read/29733743/use-of-an-animal-model-to-test-whether-non-alcoholic-fatty-liver-disease-increases-the-risk-of-idiosyncratic-drug-induced-liver-injury
#3
Alastair Mak, Tiffany Cho, Jack Uetrecht
Clinical evidence suggests that most idiosyncratic drug-induced liver injury (IDILI) is immune-mediated. The danger hypothesis suggests that liver injury and inflammation would increase the risk of an immune response leading to IDILI. Therefore, a reasonable hypothesis would be that an underlying chronic liver disease such as non-alcoholic steatohepatitis (NASH) would increase the risk of developing IDILI due to inflammation and release of danger signals from damaged cells. In order to test this hypothesis, mice were fed a methionine-/choline-deficient (MCD) diet that produces a consistent NASH phenotype, along with amodiaquine (AQ) - a drug known to cause IDILI in humans...
December 2018: Journal of Immunotoxicology
https://www.readbyqxmd.com/read/29697003/predicting-skin-sensitization-potential-of-organic-compounds-based-on-toxicity-enhancement-to-tetrahymena-pyriformis-fathead-minnow-and-daphnia-magna
#4
Weicheng Zhang, Libao Chen, Lunguang Yao
Skin sensitization is an important occupational health problem and immunotoxicity endpoint. Considering animal welfare and time and cost savings, many alternative approaches, such as those conducted in vitro, in silico, and in chemo, have been proposed and applied to predict skin sensitization of compounds. Toxicologically, sensitizers can elicit excess toxicity at greater levels than non-sensitizers due to their capacity to react with proteins/peptides. Based on this understanding, calculated toxicity enhancements (Te ) of 65 organic compounds from three in vitro bioassays, i...
December 2018: Journal of Immunotoxicology
https://www.readbyqxmd.com/read/29648480/sex-differences-impact-the-lung-bone-inflammatory-response-to-repetitive-inhalant-lipopolysaccharide-exposures-in-mice
#5
Amy J Nelson, Shyamal K Roy, Kristi Warren, Katherine Janike, Geoffrey M Thiele, Ted R Mikuls, Debra J Romberger, Dong Wang, Benjamin Swanson, Jill A Poole
Skeletal health consequences associated with inflammatory diseases of the airways significantly contribute to morbidity. Sex differences have been described independently for lung and bone diseases. Repetitive inhalant exposure to lipopolysaccharide (LPS) induces bone loss and deterioration in male mice, but comparison effects in females are unknown. Using an intranasal inhalation exposure model, 8-week-old C57BL/6 male and female mice were treated daily with LPS (100 ng) or saline for 3 weeks. Bronchoalveolar lavage fluids, lung tissues, tibias, bone marrow cells, and blood were collected...
December 2018: Journal of Immunotoxicology
https://www.readbyqxmd.com/read/29534626/nf-%C3%AE%C2%BAb-signaling-pathway-enhanced-complement-activation-mediates-renal-injury-in-trichloroethylene-sensitized-mice
#6
Min Liu, Hui Wang, Jiaxiang Zhang, Xiaodong Yang, Bodong Li, Changhao Wu, Qixing Zhu
Both NF-κB pathway and complement activation appear to be involved in kidney damage induced by trichloroethylene (TCE). However, any relationship between these two systems has not yet been established. The present study aimed to clarify the role of NF-κB in complement activation and renal injury in TCE-sensitized BALB/c mice. Mice were sensitized by an initial subcutaneous injection and repeated focal applications of TCE to dorsal skin at specified timepoints. NF-κB inhibitor pyrrolidine dithiocarbamate (PDTC) was injected (intraperitoneal) before the final two focal TCE challenges...
December 2018: Journal of Immunotoxicology
https://www.readbyqxmd.com/read/29521144/in-vitro-marker-gene-expression-analyses-in-human-peripheral-blood-mononuclear-cells-a-tool-to-assess-safety-of-influenza-vaccines-in-humans
#7
Eita Sasaki, Haruka Momose, Yuki Hiradate, Ken J Ishii, Takuo Mizukami, Isao Hamaguchi
Vaccines are inoculated in healthy individuals from children to the elderly, and thus high levels of safety and consistency of vaccine quality in each lot must meet the required specifications by using preclinical and lot release testing. Because vaccines are inoculated into humans, recapitulation of biological reactions in humans should be considered for test methods. We have developed a new method to evaluate the safety of influenza vaccines using biomarker gene expression in mouse and rat models. Some biomarker genes are already known to be expressed in human lymphocytes, macrophages and dendritic cells; therefore, we considered some of these genes might be common biomarkers for human and mice to evaluate influenza vaccine safety...
December 2018: Journal of Immunotoxicology
https://www.readbyqxmd.com/read/29514525/immunotoxic-and-hepatotoxic-effects-of-perfluoro-n-decanoic-acid-pfda-on-female-harlan-sprague-dawley-rats-and-b-6-c-3-f-1-n-mice-when-administered-by-oral-gavage-for-28-days
#8
Rachel P Frawley, Matthew Smith, Mark F Cesta, Schantel Hayes-Bouknight, Chad Blystone, Grace E Kissling, Shawn Harris, Dori Germolec
Poly- and perfluoroalkyl substances (PFAS) are chemically and thermally stable, hydrophobic, lipophobic compounds used in stain repellants and water and oil surfactants, and associated with immunosuppression and peroxisome proliferator activity. Perfluoro-n-decanoic acid (PFDA, (CF3 (CF2 )8 COOH), a fluorinated straight chain fatty acid compound, is reported to induce thymic atrophy and reversible bone marrow hypocellularity in rodent models. The objective of this study was to assess potential immunotoxicity of PFDA, due to its structural similarity to other immunosuppressive PFASs...
December 2018: Journal of Immunotoxicology
https://www.readbyqxmd.com/read/29482396/effects-of-lactational-exposure-to-low-dose-bap-on-allergic-and-non-allergic-immune-responses-in-mice-offspring
#9
Rie Yanagisawa, Eiko Koike, Tin-Tin Win-Shwe, Takamichi Ichinose, Hirohisa Takano
Benzo[a]pyrene (BaP) can induce developmental and reproductive toxicity; however, the full scope of its immunotoxic effects remains unknown. This study aimed to assess effects of lactational exposure to low-dose BaP (comparable to human exposure) on potential allergic\non-allergic immune responses in murine offspring. Lactating C3H/HeJ dams were orally dosed with BaP at 0, 0.25, 5.0, or 100 pmol/animal/week) at post-natal days [PND] 1, 8, and 15. Five-weeks-old pups then received intratracheally ovalbumin (OVA) every 2 weeks for 6 weeks...
December 2018: Journal of Immunotoxicology
https://www.readbyqxmd.com/read/29241379/prevalence-of-anti-nuclear-autoantibodies-in-subjects-exposed-to-natural-asbestiform-fibers-a-cross-sectional-study
#10
Caterina Ledda, Rosario Caltabiano, Carla Loreto, Diana Cinà, Paola Senia, Andrea Musumeci, Vincenzo Ricceri, Cristoforo Pomara, Venerando Rapisarda
Fluoro-edenite (FE) is an asbestiform mineral fiber spotted in the lava rocks excavated from a stone quarry in Biancavilla (Italy). The derived material had been employed locally for building purposes. Previous studies found evidence that exposure to asbestos may induce autoimmunity, with frequency of anti-nuclear autoantibodies (ANA). The aim of this study was to explore the relationship between FE exposure and autoimmune responses in an exposed population. For the study, 60 subjects living in the area of Biancavilla and 60 subjects as control group were randomly invited to participate...
December 2018: Journal of Immunotoxicology
https://www.readbyqxmd.com/read/29237319/fibrous-nanocellulose-crystalline-nanocellulose-carbon-nanotubes-and-crocidolite-asbestos-elicit-disparate-immune-responses-upon-pharyngeal-aspiration-in-mice
#11
Eun-Jung Park, Timur O Khaliullin, Michael R Shurin, Elena R Kisin, Naveena Yanamala, Bengt Fadeel, Jaerak Chang, Anna A Shvedova
With the rapid development of synthetic alternatives to mineral fibers, their possible effects on the environment and human health have become recognized as important issues worldwide. This study investigated effects of four fibrous materials, i.e. nanofibrillar/nanocrystalline celluloses (NCF and CNC), single-walled carbon nanotubes (CNTs), and crocidolite asbestos (ASB), on pulmonary inflammation and immune responses found in the lungs, as well as the effects on spleen and peripheral blood immune cell subsets...
December 2018: Journal of Immunotoxicology
https://www.readbyqxmd.com/read/29228829/vanadium-pentoxide-increased-pten-and-decreased-shp1-expression-in-nk-92mi-cells-affecting-pi3k-akt-mtor-and-ras-mapk-pathways
#12
Francisco Gallardo-Vera, Miguel Tapia-Rodriguez, Daniel Diaz, Teresa Fortoul van der Goes, Luis F Montaño, Erika P Rendón-Huerta
Vanadium is an air pollutant that imparts immunosuppressive effects on NK cell immune responses, in part, by dysregulating interleukin (IL)-2/IL-2R-mediated JAK signaling pathways and inducing apoptosis. The aim of the present study was to evaluate effects of vanadium pentoxide (V2 O5 ) on other IL-2 receptor-mediated signaling pathways, i.e. PI3K-AKT-mTOR and Ras-MAPK. Here, IL-2-independent NK-92MI cells were exposed to different V2 O5 doses for 24 h periods. Expression of PI3K, Akt, mTOR, ERK1/2, MEK1, PTEN, SHP1, BAD and phosphorylated forms, as well as caspases-3, -8, -9, BAX and BAK in/on the cells were then determined by flow cytometry...
December 2018: Journal of Immunotoxicology
https://www.readbyqxmd.com/read/29185370/effect-of-nicotine-on-placental-ischemia-induced-complement-activation-and-hypertension-in-the-rat
#13
Connor F Laule, Cameron R Wing, Evan J Odean, Jacob A Wilcox, Jeffrey S Gilbert, Jean F Regal
Preeclampsia is a pregnancy-specific condition manifested by new-onset maternal hypertension with systemic inflammation, including increased innate immune system complement activation. While exact pathophysiology is unknown, evidence suggests that inadequate spiral artery invasion and resulting utero-placental insufficiency is the initiating event. Cigarette smoking during pregnancy decreases the risk of preeclampsia. Nicotine, a major component of cigarettes, stimulates the efferent cholinergic anti-inflammatory pathway through peripherally expressed nicotinic acetylcholine receptors (nAChR) and is known to attenuate ischemia-reperfusion injury in kidney and liver...
December 2017: Journal of Immunotoxicology
https://www.readbyqxmd.com/read/29179596/celastrol-attenuates-impairments-associated-with-lipopolysaccharide-induced-acute-respiratory-distress-syndrome-ards-in-rats
#14
Yongjun Wei, Yu Wang
Celastrol, a constituent from a traditional Chinese medicinal herb belonging to the family Celastraceae, has been shown to impart anti-inflammatory properties, in part, by inhibiting NF-κB activity and related induction of pro-inflammatory cytokine formation/release. The present study investigated the effects of celastrol in an animal model of acute respiratory distress syndrome (ARDS) induced by intratracheal administration of lipopolysaccharides (LPSs). Celastrol pre-treatment groups received celastrol by intraperitoneal injection on seven consecutive days before LPS treatment...
December 2017: Journal of Immunotoxicology
https://www.readbyqxmd.com/read/29141474/assessment-of-immunotoxicity-in-female-fischer-344-n-and-sprague-dawley-rats-and-female-b-6-c-3-f-1-mice-exposed-to-hexavalent-chromium-via-the-drinking-water
#15
Kelly A Shipkowski, Christopher M Sheth, Matthew J Smith, Michelle J Hooth, Kimber L White, Dori R Germolec
Sodium dichromate dihydrate (SDD), an inorganic compound containing hexavalent chromium (Cr(VI)), is a common environmental contaminant of groundwater sources due to widespread industrial use. There are indications in the literature that Cr(VI) may induce immunotoxic effects following dermal exposure, including acting as both an irritant and a sensitizer; however, the potential immunomodulatory effects of Cr(VI) following oral exposure are relatively unknown. Following the detection of Cr(VI) in drinking water sources, the National Toxicology Program (NTP) conducted extensive evaluations of the toxicity and carcinogenicity of SDD following drinking water exposure, including studies to assess the potential for Cr(VI) to modulate immune function...
December 2017: Journal of Immunotoxicology
https://www.readbyqxmd.com/read/29124973/divergent-hypersensitivity-responses-following-topical-application-of-the-quaternary-ammonium-compound-didecyldimethylammonium-bromide
#16
Hillary L Shane, Ewa Lukomska, Aleksandr B Stefaniak, Stacey E Anderson
Didecyldimethylammonium bromide (DDAB) is a fourth generation dialkyl-quaternary ammonium compound (QAC) that is used in numerous products for its antimicrobial properties. While many QACs have been associated with allergic disease, the toxicity and sensitization of DDAB have not been thoroughly investigated. The purpose of these studies was to evaluate the irritancy and sensitization potential of DDAB following dermal application in a murine model. DDAB induced significant irritancy (0.0625-2%), evaluated by ear swelling in female BALB/c mice...
December 2017: Journal of Immunotoxicology
https://www.readbyqxmd.com/read/29096558/expression-of-aryl-hydrocarbon-receptor-inflammatory-cytokines-and-incidence-of-rheumatoid-arthritis-in-vietnamese-dioxin-exposed-people
#17
Chi Hung Nguyen, Taisuke Nakahama, Truong Tien Dang, Hoang Ha Chu, Luong Van Hoang, Tadamitsu Kishimoto, Nam Trung Nguyen
Many Vietnamese citizens have been and continue to be inadvertently exposed to dioxins and dioxin-like compounds deposited in the country during the Vietnam War. Dioxins may be involved in the pathogenesis of inflammatory diseases in part via by affecting expression of aryl hydrocarbon receptor (Ahr) and inflammatory cytokines in animal models. As the role of the Ahr in dioxin-exposed people is not well defined, a study was conducted to examine gene expression levels of Ahr, inflammatory cytokines, and the incidence of diseases in dioxin-exposed citizens who had/still resided near a heavily dioxin-contaminated area in Vietnam...
December 2017: Journal of Immunotoxicology
https://www.readbyqxmd.com/read/28805477/estimated-exposures-to-perfluorinated-compounds-in-infancy-predict-attenuated-vaccine-antibody-concentrations-at-age-5-years
#18
Philippe Grandjean, Carsten Heilmann, Pal Weihe, Flemming Nielsen, Ulla B Mogensen, Amalie Timmermann, Esben Budtz-Jørgensen
Perfluorinated alkylate substances (PFASs) are highly persistent and may cause immunotoxic effects. PFAS-associated attenuated antibody responses to childhood vaccines may be affected by PFAS exposures during infancy, where breastfeeding adds to PFAS exposures. Of 490 members of a Faroese birth cohort, 275 and 349 participated in clinical examinations and provided blood samples at ages 18 months and 5 years. PFAS concentrations were measured at birth and at the clinical examinations. Using information on duration of breastfeeding, serum-PFAS concentration profiles during infancy were estimated...
December 2017: Journal of Immunotoxicology
https://www.readbyqxmd.com/read/28720058/long-form-of-thymic-stromal-lymphopoietin-of-keratinocytes-is-induced-by-protein-allergens
#19
Yasutaka Kuroda, Takuo Yuki, Yutaka Takahashi, Hitoshi Sakaguchi, Kayoko Matsunaga, Hiroshi Itagaki
A growing body of evidence suggests that epicutaneous sensitization of protein allergens induces immediate-type hypersensitivity (IHS) following induction of Type 2 immune responses in animals and humans. Thymic stromal lymphopoietin (TSLP) derived from keratinocytes is a cytokine that can activate dendritic cells and has been implicated in development of inflammatory Type 2 helper T-cells. However, there is no direct evidence that allergens directly regulate TSLP expression in keratinocytes. This study aimed to evaluate the response of TSLP to protein allergens in cultured human keratinocytes and to identify appropriate endpoints for IHS...
December 2017: Journal of Immunotoxicology
https://www.readbyqxmd.com/read/28707492/bisphenol-a-bpa-aggravates-multiple-low-dose-streptozotocin-induced-type-1-diabetes-in-c57bl-6-mice
#20
Marina Cetkovic-Cvrlje, Sinduja Thinamany, Kylie A Bruner
Type 1 diabetes (T1D) is a T-cell-mediated autoimmune disorder characterized by destruction of insulin-producing pancreatic β-cells. Whereas epidemiological data implicate environmental factors in the increasing incidence of T1D, their identity remains unknown. Though exposure to bisphenol A (BPA) has been associated with several disorders, no epidemiologic evidence has linked BPA exposure and T1D. The goal of this study was to elucidate diabetogenic potentials of BPA and underlying mechanisms in the context of T-cell immunity, in a multiple low-dose streptozotocin (MLDSTZ)-induced autoimmune mouse T1D model...
December 2017: Journal of Immunotoxicology
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