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Bosnian Journal of Basic Medical Sciences

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https://www.readbyqxmd.com/read/29144891/a-plea-for-an-extension-of-the-anatomical-nomenclature-the-locomotor-system
#1
REVIEW
Vladimir Musil, Alzbeta Blankova, Vaclav Baca
Anatomical nomenclature is the main tool of communication in morphology, anatomy and other medical disciplines as well as in medical education, and thus needs to be exact, flawless, elaborate and correct. The Terminologia Anatomica (TA) is a thorough and extensive list of anatomical terms and their definitions, and the current standard for human anatomical terminology. Although several revisions to the TA have been made in the last 20 years, some important anatomical structures are still not included. This article is aimed at correcting and extending the anatomical nomenclature described in the TA...
November 16, 2017: Bosnian Journal of Basic Medical Sciences
https://www.readbyqxmd.com/read/29144890/comprehensive-analysis-of-patients-with-neuromyelitis-optica-spectrum-disorder-nmosd-combined-with-chronic-hepatitis-b-chb-infection-and-seropositive-for-anti-aquaporin-4-antibody
#2
Jia Liu, Li Xu, Zhuo-Lin Chen, Min Li, Huan Yi, Fu-Hua Peng
Previous research indicated the association between hepatitis B virus (HBV) infection/vaccination and the onset of demyelinating diseases. However, most of these studies were single case reports, and comprehensive data are still scarce. Here we present a comprehensive analysis of 10 patients with neuromyelitis optica spectrum disorder (NMOSD) combined with chronic hepatitis B (CHB) infection and seropositive for anti-aquaporin-4 antibody (AQP4-Ab). Demographic, clinical, laboratory, neuroimaging, outcome, and follow-up data of the 10 patients were retrospectively analyzed...
November 16, 2017: Bosnian Journal of Basic Medical Sciences
https://www.readbyqxmd.com/read/29131967/prognostic-role-of-the-neutrophil-to-lymphocyte-ratio-nlr-in-patients-with-operable-ampullary-carcinoma
#3
Nebi Serkan Demirci, Gokmen Umut Erdem
Ampullary carcinoma or cancer of the ampulla of Vater is a rare malignancy with a high recurrence rate. Although cost-effective biomarkers, such as neutrophil-to-lymphocyte ratio (NLR), have been investigated in other cancers for predicting postoperative prognosis in patients, studies on the role of NLR in ampullary cancer are scarce. Here we aimed to evaluate the prognostic significance of the preoperative neutrophil-to-lymphocyte ratio (NLR) in patients with operable ampullary carcinoma. We retrospectively reviewed 87 patients who underwent pancreaticoduodenectomy for the treatment of ampullary carcinoma between December 1999 and April 2014...
November 13, 2017: Bosnian Journal of Basic Medical Sciences
https://www.readbyqxmd.com/read/29080558/isoflurane-and-postoperative-respiratory-depression-following-laparoscopic-surgery-a-retrospective-propensity-matched-analysis
#4
Alexandre N Cavalcante, Carmelina Gurrieri, Juraj Sprung, Darrell R Schroeder, Toby N Weingarten
Episodes of respiratory depression during the immediate postoperative recovery period (Phase I post-anesthesia recovery) have been associated with respiratory complications during Phase II recovery. Using multivariable analyses in several surgical cohorts, we previously identified potential associations between patient and perioperative factors and increased risk for Phase I respiratory depression. The aim of this study is to use the propensity matched analysis to specifically assess for a potential association between the use of isoflurane and episodes of Phase I respiratory depression after laparoscopic operations...
October 28, 2017: Bosnian Journal of Basic Medical Sciences
https://www.readbyqxmd.com/read/29061107/non-endoscopic-minimally-invasive-evacuation-of-intracerebral-haematoma-ich-a-case-report
#5
Tomaz Velnar
Spontaneous intracerebral haemorrhage (ICH) is one of the most serious causes of stroke, leading to high rates of disability and mortality. In addition to intensive medical treatment, surgery may help to improve the prognosis in patients with ICH. A rapid reversal of coagulopathy is essential in these patients, although it may be difficult to achieve in various bleeding disorders. In such cases, when surgery is needed, a minimally invasive approach is recommended. In this case report, we described and shortly discussed the evacuation of ICH with a minimally invasive non-endoscopic surgical technique...
October 24, 2017: Bosnian Journal of Basic Medical Sciences
https://www.readbyqxmd.com/read/29055350/berberine-alleviates-oxidative-stress-in-rats-with-osteoporosis-through-receptor-activator-of-nuclear-factor-%C3%AE%C2%BA-b-receptor-activator-of-nuclear-factor-kappa-b-ligand-osteoprotegerin-rank-rankl-opg-pathway
#6
Xiao-Feng He, Long Zhang, Chun-Hua Zhang, Con-Ran Zhao, Heng Li, Ling-Fei Zhang, Guo-Feng Tian, Ming-Feng Guo, Zheng Dai, Fu-Ge Sui
Previous studies suggested that oxidative stress is related to the onset and development of osteoporosis. Moreover, it was demonstrated that berberine has a protective effect against oxidative stress-induced injuries. In this study, we aimed to investigate the effect and mechanism of action of berberine on rats with induced osteoporosis. Sixty 8-week-old female Wistar rats were randomly divided into the following 6 groups: control saline-treated, osteoporosis saline-treated, 3 osteoporosis berberine-treated groups (Ber 5, 10, and 20 mg/kg/body weight, respectively), and osteoporosis alendronate-treated (ALD) group...
October 22, 2017: Bosnian Journal of Basic Medical Sciences
https://www.readbyqxmd.com/read/29055125/vascular-endothelial-growth-factor-vegf-related-single-nucleotide-polymorphisms-rs10738760-and-rs6921438-are-not-associated-with-diabetic-retinopathy-dr-in-slovenian-patients-with-type-2-diabetes-mellitus-t2dm
#7
Rifet Terzić, Ines Cilenšek, Ruda Zorc Pleskovič, Sara Mankoč, Aleksandra Milutinović
Diabetic retinopathy (DR) is a complication of diabetes characterized by vascular permeability, increased tissue ischemia, and angiogenesis. One of the most important proteins involved in angiogenesis is vascular endothelial growth factor (VEGF, also known as VEGFA). A previous study demonstrated that two single nucleotide polymorphisms (SNPs), rs6921438 and rs10738760, account for nearly half the variation in circulating VEGF levels. The aim of our study was to assess the association between rs6921438 and rs10738760 and DR in Slovenian patients with type 2 diabetes mellitus (T2DM)...
October 20, 2017: Bosnian Journal of Basic Medical Sciences
https://www.readbyqxmd.com/read/29045804/matrine-induced-g0-g1-arrest-and-apoptosis-in-human-acute-t-cell-lymphoblastic-leukemia-t-all-cells
#8
Aslı Tetik Vardarlı, Zekeriya Düzgün, Ceren Erdem, Burçin Tezcanli Kaymaz, Zuhal Eroglu, Vildan Bozok Çetintas
Matrine, a natural product extracted from the root of Sophora flavescens, is a promising alternative drug in different types of cancer. Here, we aimed to investigate the therapeutic effects and underlying molecular mechanisms of matrine on human acute lymphoblastic leukemia (ALL) cell line, CCRF-CEM. Cell viability and IC50 values were determined by WST-1 cell cytotoxicity assay. Cell cycle distribution and apoptosis rates were analyzed by flow cytometry. Expression patterns of 44 selected miRNAs and 44 RNAs were analyzed by quantitative reverse transcription polymerase chain reaction (qRT-PCR) using the Applied Biosystems 7500 Fast Real-Time PCR System...
October 18, 2017: Bosnian Journal of Basic Medical Sciences
https://www.readbyqxmd.com/read/28976870/efficacy-of-a-bundle-approach-in-preventing-the-incidence-of-ventilator-associated-pneumonia-vap
#9
Sandra Burja, Tina Belec, Nika Bizjak, Jernej Mori, Andrej Markota, Andreja Sinkovič
Ventilator-associated pneumonia (VAP) is a potentially preventable iatrogenic illness that may develop following mechanical ventilation. A bundle for the prevention of VAP consists of different measures which may vary between institutions, and may include: elevation of the head of the bed, oral care with chlorhexidine, subglottic suctioning, daily assessment for extubation and the need for proton-pump inhibitors, use of closed suction systems, and maintaining endotracheal cuff pressure at 25 cmH2O. Our aim was to determine the efficacy of a VAP prevention bundle, consisting of the above-mentioned measures, by evaluating the incidence of VAP before (no-VAP-B group) and after (VAP-B group) the introduction of the bundle...
October 4, 2017: Bosnian Journal of Basic Medical Sciences
https://www.readbyqxmd.com/read/28968197/safety-of-once-or-twice-daily-dosing-of-non-vitamin-k-antagonist-oral-anticoagulants-noacs-in-patients-with-nonvalvular-atrial-fibrillation-a-noac-tr-study
#10
Sadık Volkan Emren, Mehdi Zoghi, Rida Berılgen, İbrahim Halil Özdemir, Oğuzhan Çelik, Nurullah Çetin, Asım Enhoş, Cemal Köseoğlu, Abdurrahman Akyüz, Volkan Doğan, Fatih Levent, Yüksel Dereli, Tolga Doğan, Özcan Başaran, Ilgın Karaca, Özkan Karaca, Yılmaz Ömür Otlu, Çağlar Özmen, Selvi Coşar, Mutlu Sümerkan, Erdal Gürsul, Sinan İnci, Ersel Onrat, Oktay Ergene
Once-daily dosing of non-vitamin K antagonist oral anticoagulants (NOACs) may increase patient adherence to treatment but may also be associated with a higher risk of bleeding. In this study, we investigated the adherence to once- or twice-daily dosing of NOACs and the risk of bleeding in nonvalvular atrial fibrillation (NVAF) patients. This multicenter cross-sectional study, conducted between 1 September 2015 and 28 February 2016, included 2214 patients receiving NOACs for at least 3 months, due to NVAF. Patients receiving once-daily or twice-daily NOAC doses were 1:1 propensity score matched for baseline demographic characteristics and the presence of other diseases...
October 2, 2017: Bosnian Journal of Basic Medical Sciences
https://www.readbyqxmd.com/read/28961087/the-kampo-medicine-yokukansan-yks-enhances-nerve-growth-factor-ngf-induced-neurite-outgrowth-in-pc12-cells
#11
Kazuki Terada, Yukari Matsushima, Kazuhisa Matsunaga, Jiro Takata, Yoshiharu Karube, Atsushi Ishige, Koji Chiba
Accumulating evidence indicates that neurotrophic factor-like substances involved in the induction of neurotrophic factor synthesis may aid in the treatment of neurological disorders, such as Alzheimer's disease. Yokukansan (YKS), a traditional Kampo medicine, has been used for the treatment of anxiety and mood disorders. In the present study, we analyzed the neurite length of nerve growth factor (NGF)-treated rat pheochromocytoma (PC12) cells via Western blot analysis. Akt and extracellular-regulated kinase 1/2 (ERK1/2) phosphorylation levels were assessed in the presence of YKS and following the treatment with TrkA inhibitor, K252a...
September 28, 2017: Bosnian Journal of Basic Medical Sciences
https://www.readbyqxmd.com/read/28954205/etoricoxib-improves-osteoarthritis-pain-relief-joint-function-and-quality-of-life-in-the-extreme-elderly
#12
Wen-Nan Huang, Tim K Tso
Etoricoxib is a selective cyclooxygenase-2 (COX-2) inhibitor, with a lower risk of gastrointestinal toxicity compared to traditional nonsteroidal anti-inflammatory drugs (NSAIDs). We evaluated the effectiveness and tolerability of etoricoxib in extreme elderly patients with chronic pain due to osteoarthritis (OA). A prospective, single-center, single-arm study was conducted, enrolling 19 extreme elderly men with OA (mean age 85.9, range 79-96 years), who responded inadequately to NSAIDs or other analgesics...
September 27, 2017: Bosnian Journal of Basic Medical Sciences
https://www.readbyqxmd.com/read/28954204/oligoasthenoteratozoospermic-oat-men-display-altered-phospholipase-c-%C3%AE-plc%C3%AE-localization-and-a-lower-percentage-of-sperm-cells-expressing-plc%C3%AE-and-post-acrosomal-sheath-ww-domain-binding-protein-pawp
#13
Nahid Azad, Hamid Nazarian, Marefat Ghaffari Novin, Reza Masteri Farahani, Abbas Piryaei, Mohammad Hassan Heidari, Meghdad Abdollahpour Alitappeh
Oligoasthenoteratozoospermia (OAT) is demonstrated to be one of the most common causes of male subfertility. Phospholipase C ζ (PLCζ), a sperm-specific protein, is considered to be one of the sperm-borne oocyte activating factors (SOAFs), which play a vital role in fertilization. The post-acrosomal sheath WW domain-binding protein (PAWP) is another candidate for SOAF. The aim of this study was to compare the PLCζ localization patterns and percentage of PLCζ- and PAWP-positive sperm cells in patients with OAT and fertile men with normozoospermia...
September 27, 2017: Bosnian Journal of Basic Medical Sciences
https://www.readbyqxmd.com/read/28954203/physiological-and-transcriptomic-analysis-of-a-salt-resistant-saccharomyces-cerevisiae-mutant-obtained-by-evolutionary-engineering
#14
Seyma Hande Tekarslan-Sahin, Ceren Alkim, Tugba Sezgin
Salt-resistant yeast strains are highly demanded by industry due to the exposure of yeast cells to high concetrations of salt, in various industrial bioprocesses. The aim of this study was to perform a physiological and transcriptomic analysis of a salt-resistant Saccharomyces cerevisiae (S. cerevisiae) mutant generated by evolutionary engineering. NaCl-resistant S. cerevisiae strains were obtained by ethyl methane sulfonate (EMS) mutagenesis followed by successive batch cultivations in the presence of gradually increasing NaCl concentrations, up to 8...
September 27, 2017: Bosnian Journal of Basic Medical Sciences
https://www.readbyqxmd.com/read/28941466/5-fluorouracil-leucovorin-and-irinotecan-folfiri-as-a-third-line-chemotherapy-treatment-in-metastatic-gastric-cancer-after-failure-of-fluoropyrimidine-platinum-anthracycline-and-taxane
#15
Gokmen Umut Erdem, Yakup Bozkaya, Nuriye Yıldırım Özdemir, Nebi Serkan Demirci, Ozan Yazıcı, Nurullah Zengin
Studies on the effects of third-line chemotherapy (CT) in advanced gastric cancer (GC) patients are still scarce. The aim of this study was to evaluate the efficacy and safety of the modified 5 fluorouracil, leucovorin, and irinotecan (mFOLFIRI) regimen as a third-line CT in metastatic GC patients, after failure of fluoropyrimidine, platinum, anthracycline, and taxane. After failure of first- and second-line therapy, 42 patients received a third-line FOLFIRI (180 mg/m² irinotecan and 400 mg/m²leucovorin administered concomitantly as a 90-minute intravenous (IV) infusion on day 1, followed by a 400 mg/m² 5-fluorouracil IV bolus then 2600 mg/m² continuous infusion over 46 hours), between January 2009 and December 2015...
September 24, 2017: Bosnian Journal of Basic Medical Sciences
https://www.readbyqxmd.com/read/28926321/evaluation-of-platelet-activation-during-storage-in-leukocyte-depleted-platelet-concentrates
#16
Miodrag Vucic, Zoran Stanojkovic, Ana Antic, Jelana Vucic, Voja Pavlovic
Structural and functional changes in platelets during storage can lead to the loss of platelet reactivity and response. Our aim was to evaluate leukocyte-depleted platelet concentrates, obtained by in-line filtration on storage days 0, 3 and 5. In non-filtered platelet concentrates (NF-PC) group, 180 whole blood units were collected with quadruple blood bags and then compared to another group of 180 whole blood units (leukocyte-depleted platelet concentrates [LD-PC]), collected in Imuflex Whole Blood Filter Saving Platelets (WB-SP) bags with an integrated leukoreduction filter, with regard to the platelet quality and characteristics...
September 19, 2017: Bosnian Journal of Basic Medical Sciences
https://www.readbyqxmd.com/read/28926322/vitamin-d-status-serum-lipid-concentrations-and-vitamin-d-receptor-vdr-gene-polymorphisms-in-familial-mediterranean-fever
#17
Turan Turhan, Halef Okan Doğan, Nihal Boğdaycioğlu, Nilnur Eyerci, Ahmet Omma, İsmail Sari, Ahmet Yeşilyurt, Yaşar Karaaslan
Vitamin D (VitD) is critical for the regulation of inflammatory processes, and VitD deficiency has been linked to several chronic inflammatory disorders. We aimed to investigate the concentrations of serum 25(OH)D3, lipid parameters, and three known VDR polymorphisms (BsmI, FokI, and TaqI) in patients with Familial Mediterranean fever (FMF), an autosomal recessive autoinflammatory disease. The study included 123 FMF patients and 105 controls. A total of 38 patients were in acute attacks at the time of investigation...
September 18, 2017: Bosnian Journal of Basic Medical Sciences
https://www.readbyqxmd.com/read/28812534/microsatellite-instability-status-predicts-response-to-anti-pd-1-pd-l1-therapy-regardless-the-histotype-a-comment-on-recent-advances
#18
LETTER
Semir Vranic
No abstract text is available yet for this article.
August 20, 2017: Bosnian Journal of Basic Medical Sciences
https://www.readbyqxmd.com/read/28686849/lack-of-association-between-urotensin-ii-uts2-gene-polymorphisms-thr21met-and-ser89asn-and-migraine
#19
Betül Ozan, Seniz Demiryürek, Muhammad Safdar, Yusuf Inanc, Abdullah Tuncay Demiryürek
Migraine is a common neurovascular brain disorder with heterogeneous clinical presentation, including recurrent headache attacks. The pathophysiology of migraine is complex, and a number of genomic regions have been associated with the development of migraine. In this study, we analyzed the allele and genotype frequencies of the urotensin-II gene (UTS2) polymorphisms, Thr21Met and Ser89Asn, among Turkish patients with migraine. A total of 146 patients with migraine (14 with aura [MA group] and 132 without aura [MO group]) were genotyped for Thr21Met and Ser89Asn polymorphisms and compared with 154 age- and sex-matched healthy controls...
August 20, 2017: Bosnian Journal of Basic Medical Sciences
https://www.readbyqxmd.com/read/28628756/atypical-sympathomimetic-drug-lerimazoline-mediates-contractile-effects-in-rat-aorta-predominantly-by-5-ht2a-receptors
#20
Eldina Rizvić, Goran Janković, Slađana Kostić-Rajačić, Miroslav M Savić
Lerimazoline is a sympathomimetic drug that belongs to the imidazoline class of compounds, and is used as a nasal decongestant. Studies on lerimazoline are rare, and its pharmacological profile is not completely understood. Here, we analyzed the affinity of lerimazoline for dopamine receptor D2, serotonin 5-HT1A and 5-HT2A receptors and α1-adrenoceptor, and investigated lerimazoline contractile effects in isolated rat thoracic aorta. We also determined the effect of several antagonists on the contractile response to lerimazoline, including prazosin (α1-adrenoceptor antagonist), RX 821002 and rauwolscine (α2-adrenoceptor antagonists), JP 1302 (α2C-adrenoceptor antagonist), methiothepin (non-selective 5-HT receptor antagonist), SB 224289 (5-HT1B receptor antagonist), BRL 15572 (5-HT1D receptor antagonist), and ketanserin (5-HT2A receptor antagonist)...
August 20, 2017: Bosnian Journal of Basic Medical Sciences
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