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Bosnian Journal of Basic Medical Sciences

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https://www.readbyqxmd.com/read/28178430/nitric-oxide-synthesis-promoting-effects-of-valsartan-in-human-umbilical-vein-endothelial-cells-via-the-akt-adenosine-monophosphate-activated-protein-kinase-endothelial-nitric-oxide-synthase-pathway
#1
Yingshuai Zhao, Liuyi Wang, Shanshan He, Xiaoyan Wang, Weili Shi
Valsartan (VAL), an antagonist of angiotensin II receptor type 1, has antihypertensive and multiple cardiovascular protective effects. The pleiotropic functions of VAL are related to the increased synthesis and biological activity of intravascular nitric oxide (NO). In this study, the role and mechanisms of VAL in the synthesis of NO were examined in human umbilical vein endothelial cells (HUVECs). Ten µmol/L of VAL was used to treat EA.hy926 cells for 30 minutes, 1, 3, 6, 12, and 24 hours, and three concentrations of VAL (i...
February 8, 2017: Bosnian Journal of Basic Medical Sciences
https://www.readbyqxmd.com/read/28146420/a-silent-mutation-in-human-alpha-a-crystallin-gene-in-patients-with-age-related-nuclear-or-cortical-cataract
#2
Bharani K Mynampati, Thungapathra Muthukumarappa, Sujata Ghosh, Jagat Ram
A cataract is a complex multifactorial disease that results from alterations in the cellular architecture, i.e. lens proteins. Genes associated with the development of lens include crystallin genes. Although crystallins are highly conserved proteins among vertebrates, a significant number of polymorphisms exist in human population. In this study, we screened for polymorphisms in crystallin alpha A (CRYAA) and alpha B (CRYAB) genes in 200 patients over 40 years of age, diagnosed with age-related cataract (ARC; nuclear and cortical cataracts)...
February 1, 2017: Bosnian Journal of Basic Medical Sciences
https://www.readbyqxmd.com/read/28135566/anatomical-and-functional-outcomes-of-scleral-buckling-versus-primary-vitrectomy-in-pseudophakic-retinal-detachment
#3
Veysel Cankurtaran, Mehmet Citirik, Mert Simsek, Kemal Tekin, Mehmet Yasin Teke
Retinal detachment is the separation of the sensory retina from the retinal pigment epithelium by subretinal fluid. There are several types of retinal re-attachment surgery, including scleral buckling (SB), pneumatic retinopexy, and vitrectomy (with or without SB). The objective of this study was to compare anatomical and visual outcomes between patients with pseudophakic rhegmatogenous retinal detachment (RRD) who underwent pars plana vitrectomy (PPV) with silicone oil (SO) or perfluoropropane (C3F8) gas tamponade and pseudophakic RRD patients who underwent SB surgery...
January 30, 2017: Bosnian Journal of Basic Medical Sciences
https://www.readbyqxmd.com/read/28135567/tafro-syndrome-new-subtype-of-idiopathic-multicentric-castleman-disease
#4
REVIEW
Gordan Srkalovic, Inga Marijanovic, Maya B Srkalovic, David C Fajgenbaum
Castleman disease (CD) describes a group of three rare and poorly understood lymphoproliferative disorders that have heterogeneous clinical symptoms and common lymph node histopathological features. Unicentric CD (UCD) involves a single region of enlarged nodes. Multicentric CD (MCD) involves multiple regions of enlarged lymph nodes, constitutional symptoms, and organ dysfunction due to a cytokine storm often including interleukin 6. MCD is further divided into Human Herpes Virus-8 (HHV-8)-associated MCD, which occurs in immunocompromised individuals, and HHV-8-negative/idiopathic MCD (iMCD)...
January 26, 2017: Bosnian Journal of Basic Medical Sciences
https://www.readbyqxmd.com/read/28086064/dose-and-time-dependent-effects-of-clodronate-on-orthodontic-tooth-movement
#5
Enita Nakaš, Tomislav Lauc, Alisa Tiro, Vildana Džemidžić, Amila Zukanović, Miljenko Franić, Vladimir Ivković
Orthodontic tooth movement is the result of bone remodeling that occurs in periodontal ligament and alveolar bone tissue as a response to mechanical loading of the tooth. The aim of this study is to investigate the time- and dose-response effects of locally administered clodronate on tooth movement. Sixty Wistar rats were randomly assigned to 4 groups of 15 specimens: E1 - application of 10 mMol of clodronate in 3-day intervals; E2 - application of 2.5 mMol of clodronate in 3-day intervals; E3 - application of 10 mMol of clodronate in 7-day intervals; E4 - application of 2...
January 13, 2017: Bosnian Journal of Basic Medical Sciences
https://www.readbyqxmd.com/read/28086065/defective-autophagy-is-associated-with-neuronal-injury-in-a-mouse-model-of-multiple-sclerosis
#6
Xuedan Feng, Huiqing Hou, Yueli Zou, Li Guo
Neurodegeneration, along with inflammatory demyelination, is an important component of multiple sclerosis (MS) pathogenesis. Autophagy is known to play a pivotal role in neuronal homeostasis and is implicated in several neurodegenerative disorders. However, whether autophagy is involved in the mechanisms of neuronal damage during MS remains to be investigated. Experimental autoimmune encephalomyelitis (EAE), an in vivo model of MS, was induced in female C57BL/6 mice by immunization with myelin oligodendrocyte glycoprotein p35-55...
January 12, 2017: Bosnian Journal of Basic Medical Sciences
https://www.readbyqxmd.com/read/28027453/pethidine-efficacy-in-achieving-the-ultrasound-guided-oblique-subcostal-transversus-abdominis-plane-block-in-laparoscopic-cholecystectomy-a-prospective-study
#7
Caius Mihai Breazu, Lidia Ciobanu, Adrian Bartos, Raluca Bodea, Petru Adrian Mircea, Daniela Ionescu
Pethidine is a synthetic opioid with local anesthetic properties. Our goal was to evaluate the analgesic efficacy of pethidine for achieving the ultrasound-guided oblique subcostal transversus abdominis plane (OSTAP) block in laparoscopic cholecystectomy. This prospective, double-blind study included 79 patients of physical status I and II according to American Society of Anesthesiologists, scheduled for elective laparoscopic cholecystectomy. The patients were randomly allocated into three groups, depending on the drug used to achieve preoperative bilateral OSTAP block: 1) OSTAP-Placebo (treated with normal saline); 2) OSTAP-Bupivacaine (treated with 0...
December 27, 2016: Bosnian Journal of Basic Medical Sciences
https://www.readbyqxmd.com/read/28027456/immunohistochemical-localization-of-ionotropic-glutamate-receptors-in-the-rat-red-nucleus
#8
Zehra Minbay, Sema Serter Kocoglu, Duygu Gok Yurtseven, Ozhan Eyigor
In this study, we aimed to determine the presence as well as the diverse distribution of N-methyl-D-aspartate (NMDA) and non-NMDA glutamate receptor subunits in the rat red nucleus. Using adult Sprague-Dawley rats as the experimental animals, immunohistochemistry was performed on 30 µm thick coronal brain sections with antibodies against α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (GluA1-4), kainate (GluK1, GluK2/3, and GluK5), and NMDA (GluN1 and GluN2A) receptor subunits. The results showed that all ionotropic glutamate receptor subunits are expressed in the red nucleus...
December 21, 2016: Bosnian Journal of Basic Medical Sciences
https://www.readbyqxmd.com/read/28027455/analysis-of-pulmonary-surfactant-by-fourier-transform-infrared-spectroscopy-after-exposure-to-sevoflurane-and-isoflurane
#9
Vilena Vrbanović Mijatović, Ljiljana Šerman, Ozren Gamulin
Pulmonary surfactant, consisting primarily of phospholipids and four surfactant-specific proteins, is among the first structures that is exposed to inhalation anesthetics. Consequently, changes of pulmonary surfactant due to this exposure could cause respiratory complications after long anesthetic procedures. Fourier transform infrared (FTIR) spectroscopy was used to explore the effects of two inhalation anesthetics, sevoflurane and isoflurane, on a commercially available pulmonary surfactant. The research was primarily focused on the effect of anesthetics on the lipid component of the surfactant...
December 21, 2016: Bosnian Journal of Basic Medical Sciences
https://www.readbyqxmd.com/read/28027454/apocrine-carcinoma-of-the-breast-a-brief-update-on-the-molecular-features-and-targetable-biomarkers
#10
REVIEW
Semir Vranic, Rebecca Feldman, Zoran Gatalica
Apocrine carcinoma of the breast is a rare, primary breast cancer characterized by the apocrine morphology, estrogen receptor-negative and androgen receptor-positive profile with a frequent overexpression of Her-2/neu protein (~30%). Apart from the Her-2/neu target, advanced and/or metastatic apocrine carcinomas have limited treatment options. In this review, we briefly describe and discuss the molecular features and new theranostic biomarkers for this rare mammary malignancy. The importance of comprehensive profiling is highlighted due to synergistic and potentially antagonistic molecular events in the individual patients...
December 21, 2016: Bosnian Journal of Basic Medical Sciences
https://www.readbyqxmd.com/read/27968707/enantiomer-specific-ketorolac-pharmacokinetics-in-young-women-including-pregnancy-and-postpartum-period
#11
Aida Kulo, Anne Smits, Sanita Maleškić, Marc Van de Velde, Kristel Van Calsteren, Jan De Hoon, Rene Verbesselt, Jan Deprest, Karel Allegaert
Racemic ketorolac clearance (CL) is significantly higher at delivery, but S-ketorolac disposition determines the analgesic effects. The aim of this study was to investigate the effect of pregnancy and postpartum period on enantiomer-specific (S and R) intravenous (IV) ketorolac pharmacokinetics (PKs). Data in women shortly following cesarean delivery (n=39) were pooled with data in a subgroup of these women that was reevaluated in the later postpartum period (postpartum group, n=8/39) and with eight healthy female volunteers...
November 22, 2016: Bosnian Journal of Basic Medical Sciences
https://www.readbyqxmd.com/read/27968706/radiopacity-of-alloplastic-bone-grafts-measured-with-cone-beam-computed-tomography-an-analysis-in-rabbit-calvaria
#12
Cristina Bucchi, Eduardo Borie, Alain Arias, Fernando José Dias, Ramón Fuentes
Availability of adequate bone structure for dental implants is still a problem in dentistry. Alloplastic grafts, which promote bone regeneration, are used as bone substitutes in orthopedic and oral surgical procedures. The aim of this study was to evaluate the radiopacity of three different synthetic bone grafts in rabbit calvaria, over 3 months, using cone beam computed tomography (CBCT). Four critical-size defects were made on the calvaria of 11 rabbits. The lesions were classified into three groups according to the alloplastic grafts they received: Osteon® 70/30, Osteon collagen®, and Osteon II® groups...
November 22, 2016: Bosnian Journal of Basic Medical Sciences
https://www.readbyqxmd.com/read/27968708/dl-2-amino-3-phosphonopropionic-acid-protects-primary-neurons-from-oxygen-glucose-deprivation-induced-injury
#13
Di Cui, Jun Xu, Quanyi Xu, Guokun Zuo
Cerebral infarction is a type of ischemic stroke and is one of the main causes of irreversible brain damage. Although multiple neuroprotective agents have been investigated recently, the potential of DL-2-amino-3-phosphonopropionic acid (DL-AP3) in treating oxygen-glucose deprivation (OGD)-induced neuronal injury, has not been clarified yet. This study was aimed to explore the role of DL-AP3 in primary neuronal cell cultures. Primary neurons were divided into four groups: (1) a control group that was not treated; (2) DL-AP3 group treated with 10 μM of DL-AP3; (3) OGD group, in which neurons were cultured under OGD conditions; and (4) OGD + DL-AP3 group, in which OGD model was first established and then the cells were treated with 10 μM of DL-AP3...
November 17, 2016: Bosnian Journal of Basic Medical Sciences
https://www.readbyqxmd.com/read/27754828/small-interfering-rna-mediated-silencing-of-nicotinamide-phosphoribosyltransferase-nampt-and-lysosomal-trafficking-regulator-lyst-induce-growth-inhibition-and-apoptosis-in-human-multiple-myeloma-cells-a-preliminary-study
#14
Ivyna Pau Ni Bong, Ching Ching Ng, Shaik Kamal Fakiruddin, Moon Nian Lim, Zubaidah Zakaria
Multiple myeloma (MM) is a malignancy of B lymphocytes or plasma cells. Our array-based comparative genomic hybridization findings revealed chromosomal gains at 7q22.3 and 1q42.3, where nicotinamide (NAM) phosphoribosyltransferase (NAMPT) and lysosomal trafficking regulator (LYST) genes are localized, respectively. This led us to further study the functions of these genes in myeloma cells. NAMPT is a key enzyme involved in nicotinamide adenine dinucleotide salvage pathway, and it is frequently overexpressed in human cancers...
November 10, 2016: Bosnian Journal of Basic Medical Sciences
https://www.readbyqxmd.com/read/27754827/high-mobility-group-box-1-induces-the-activation-of-the-janus-kinase-2-and-signal-transducer-and-activator-of-transcription-3-jak2-stat3-signaling-pathway-in-pancreatic-acinar-cells-in-rats-while-ag490-and-rapamycin-inhibit-their-activation
#15
Guoliang Wang, Jingchao Zhang, Danhua Dui, Haoyuan Ren, Jin Liu
The pathogenesis of severe acute pancreatitis (SAP) remains unclear. The Janus kinase and signal transducer and activator of transcription (JAK/STAT) pathway is important for various cytokines and growth factors. This study investigated the effect of the late inflammatory factor high mobility group box 1 (HMGB1) on the activation of JAK2/STAT3 in pancreatic acinar cells and the inhibitory effects of AG490 (a JAK2 inhibitor) and rapamycin (a STAT3 inhibitor) on this pathway. Rat pancreatic acinar cells were randomly divided into the control, HMGB1, AG490, and rapamycin groups...
November 10, 2016: Bosnian Journal of Basic Medical Sciences
https://www.readbyqxmd.com/read/27648989/incidence-of-prediabetes-and-risk-of-developing-cardiovascular-disease-in-women-with-polycystic-ovary-syndrome
#16
Zelija Velija-Asimi, Azra Burekovic, Tanja Dujic, Amela Dizdarevic-Bostandzic, Sabina Semiz
Our aim was to determine the incidence of prediabetes and risk of developing cardiovascular disease (CVD) in women with polycystic ovary syndrome (PCOS). This prospective, observational study included 148 women with PCOS, without Type 2 diabetes mellitus (T2DM) and CVD present at baseline. In the fasting blood samples, we measured lipids, glucose, and insulin levels during oral glucose tolerance test, levels of C-reactive protein (CRP), steroids, 25-hydroxyvitamin D (25-OHD), prolactin, thyroid-stimulating hormone, and parathyroid hormone...
November 10, 2016: Bosnian Journal of Basic Medical Sciences
https://www.readbyqxmd.com/read/27524109/nesfatin-1-alleviates-extrahepatic-cholestatic-damage-of-liver-in-rats
#17
Ali Solmaz, Osman Bilgin Gülçiçek, Candaş Erçetin, Hakan Yiğitbaş, Erkan Yavuz, Sinan Arıcı, Can Erzik, Oğuzhan Zengi, Pelin Demirtürk, Atilla Çelik, Fatih Çelebi
Obstructive jaundice (OJ) can be defined as cessation of bile flow into the small intestine due to benign or malignant changes. Nesfatin-1, recently discovered anorexigenic peptide derived from nucleobindin-2 in hypothalamic nuclei, was shown to have anti-inflammatory and antiapoptotic effects. This study is aimed to investigate the therapeutic effects of nesfatin-1 on OJ in rats. Twenty-four adult male Wistar-Hannover rats were randomly assigned to three groups: sham (n = 8), control (n = 8), and nesfatin (n = 8)...
November 10, 2016: Bosnian Journal of Basic Medical Sciences
https://www.readbyqxmd.com/read/27455119/unknown-primary-adenocarcinomas-a-single-center-experience
#18
Sernaz Uzunoglu, Bulent Erdogan, Hilmi Kodaz, Ahmet Cinkaya, Esma Turkmen, Ilhan Hacibekiroglu, Ali Sari, Alaattin Ozen, Ufuk Usta, Irfan Cicin
This study aimed to elucidate the clinical and prognostic characteristics of a homogeneous group of patients with cancer of unknown primary (CUP). Between 1999 and 2014, CUP was diagnosed in 159 (1.3%) of 11,742 cancer patients at Trakya University Hospital (Edirne, Turkey). Ninety-seven (61%) of the 159 patients were retrospectively reviewed. Among these, 61 (62.8%) patients with adenocarcinoma were included in this study. The most frequently predicted primary tumor site was the lung (37.7%), and 59% of the patients were smokers...
November 10, 2016: Bosnian Journal of Basic Medical Sciences
https://www.readbyqxmd.com/read/27409643/comparison-of-proseal-laryngeal-mask-airway-plma-with-cuffed-and-uncuffed-endotracheal-tubes-in-infants
#19
COMPARATIVE STUDY
Eyyup Sabri Ozden, Basak Ceyda Meco, Zekeriyya Alanoglu, Neslihan Alkıs
We aimed to compare cuffed and uncuffed endotracheal tubes (ETTs) with ProSealTM laryngeal mask airway (PLMA) in terms of airway security and extubation, starting out from the hypothesis that PLMA will provide alternative airway safety to the endotracheal tubes, and that airway complications will be less observed. After obtaining approval from the local Ethics Committee and parental informed consent, 120 pediatric patients 1-24 months old, American Society of Anesthesiologists physical status I-II, requiring general anesthesia for elective lower abdominal surgery, were randomized into PLMA (Group P, n = 40), cuffed ETT (Group C, n = 40), and uncuffed ETT (Group UC, n = 40) groups...
November 10, 2016: Bosnian Journal of Basic Medical Sciences
https://www.readbyqxmd.com/read/27371767/impact-of-active-smoking-on-survival-of-patients-with-metastatic-lung-adenocarcinoma-harboring-an-epidermal-growth-factor-receptor-egfr-mutation
#20
Bulent Erdogan, Hilmi Kodaz, Senem Karabulut, Ahmet Cinkaya, Hilmi Tozkir, Ozgur Tanriverdi, Devrim Cabuk, Muhammed Bekir Hacioglu, Esma Turkmen, Ilhan Hacibekiroglu, Sernaz Uzunoglu, Irfan Cicin
Lung cancer in smokers and non-smokers demonstrates distinct genetic profiles, and cigarette smoking affects epidermal growth factor receptor (EGFR) function and causes secondary EGFR tyrosine kinase resistance. We evaluated the effect of active smoking in patients with metastatic lung adenocarcinoma. A total of 132 metastatic lung adenocarcinoma patients, diagnosed between 2008 and 2013, with known EGFR mutation status, were evaluated retrospectively. Among these patients, 40 had an activating EGFR mutation...
November 10, 2016: Bosnian Journal of Basic Medical Sciences
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