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Bosnian Journal of Basic Medical Sciences

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https://www.readbyqxmd.com/read/29984679/clinical-features-and-management-of-oral-lichen-planus-olp-with-emphasis-on-the-management-of-hepatitis-c-virus-hcv-related-olp
#1
REVIEW
Alexandru Mester, Ondine Lucaciu, Lidia Ciobanu, Dragos Apostu, Aranka Ilea, Radu Septimiu Campian
Oral lichen planus (OLP) is a chronic inflammatory disease characterized by the occurrence of multiple, symmetrical lesions in the oral cavity. Hepatitis C virus (HCV) infection has been suggested as an etiological factor in OLP. The purpose of this review was to summarize the current literature regarding the treatment of OLP in patients with HCV infection. An electronic search of the PubMed database was conducted until January 2018, using the following keywords: OLP, HCV, corticosteroids, retinoids, immunomodulatory agents, surgical interventions, photochemotherapy, laser therapy, interferon, ribavirin, and direct-acting antivirals...
July 7, 2018: Bosnian Journal of Basic Medical Sciences
https://www.readbyqxmd.com/read/29984678/effects-of-epinephrine-on-heart-rate-variability-and-cytokines-in-a-rat-sepsis-model
#2
Yun-Te Chang, Wei-Chun Huang, Chin-Chang Cheng, Meng-Wei Ke, Jung-Shun Tsai, Yao-Min Hung, Neng-Chyan Huang, Mu-Shun Huang, Shue-Ren Wann
Catecholamines have both anti-inflammatory and vasoactive properties. A decreased cardiac response to catecholamines has been associated with a high risk of death in sepsis and septic shock. The aim of this study was to investigate the effects of epinephrine (EPI) on heart rate variability and autonomic balance, as well as cytokine levels, in a rat sepsis model. Thirty-six male Sprague-Dawley rats were assigned to 4 experimental groups and 2 control groups of 6 rats each. The rats in the experimental groups were inoculated with a lipopolysaccharide (LPS, endotoxin) to establish a sepsis model...
July 7, 2018: Bosnian Journal of Basic Medical Sciences
https://www.readbyqxmd.com/read/29984677/delirium-following-total-joint-replacement-surgery
#3
Jeffrey Huang, Juraj Sprung, Toby N Weingarten
Postoperative delirium (POD) is a common complication associated with increased resource utilization, morbidity and mortality. Our institution screens all postsurgical patients for postoperative delirium. The study aim was to perform an automated interrogation of the electronic health records to estimate the incidence of and identify associated risk factors for POD following total joint arthroplasty (TJA). Adult patients who underwent TJA with a multimodal analgesia protocol, including peripheral nerve blockade, from 2008 through 2012, underwent automated chart review...
July 7, 2018: Bosnian Journal of Basic Medical Sciences
https://www.readbyqxmd.com/read/29984676/simple-reliable-and-time-efficient-colorimetric-method-for-the-assessment-of-mitochondrial-function-and-toxicity
#4
Faraz Ahmad, Widyan Alamoudi, Shafiul Haque, Mohammad Salahuddin, Khaldoon Alsamman
Mitochondria are organelles involved in the production of cellular energy, regulation of Ca2+ and redox signaling, and are critical for normal functioning of eukaryotic cells. The dysfunction of mitochondria has been implicated in a wide range of diseases, including metabolic and neurodegenerative disorders and different types of cancers. To better understand the role of mitochondria in healthy and disease states, the development of efficient and reliable tools for the assessment of mitochondrial function is particularly important...
July 7, 2018: Bosnian Journal of Basic Medical Sciences
https://www.readbyqxmd.com/read/29924960/p16-ki-67-dual-staining-has-a-better-accuracy-than-human-papillomavirus-hpv-testing-in-women-under-30-years-old
#5
Laurențiu Pirtea, Cristina Secosan, Madalin Margan, Lavinia Moleriu, Oana Balint, Dorin Grigoras, Ioan Sas, Florin Horhat, Adelina Jianu, Răzvan Ilina
Due to a high rate of transient human papillomavirus (HPV) infection, HPV genotyping has a low specificity for high-grade cervical lesions, especially in young women. p16/Ki-67 dual immunohistochemical staining can also be used for the detection of oncogenic changes in cervical cells. Our aim was to compare the performance of p16/Ki-67 dual staining and HPV genotyping in the detection of high-grade cervical lesions in patients with atypical squamous cells of undetermined significance (ASCUS)/low-grade squamous intraepithelial lesion (LSIL) on Pap smear...
June 20, 2018: Bosnian Journal of Basic Medical Sciences
https://www.readbyqxmd.com/read/29924959/immunohistochemical-expression-of-nedd9-e-cadherin-and-%C3%AE-catenin-and-their-prognostic-significance-in-pancreatic-ductal-adenocarcinoma-pdac
#6
Petra Radulović, Božo Krušlin
Extensive research is being conducted to identify novel diagnostic, predictive and prognostic biomarkers for pancreatic ductal adenocarcinoma (PDAC), as only a few markers have been routinely used so far with limited success. Our aim was to assess the expression of neural precursor cell expressed developmentally down-regulated protein 9 (NEDD9), E-cadherin, and γ-catenin in PDAC in relation to clinicopathological parameters and patient survival. We also investigated if there is a correlation of NEDD9 expression with E-cadherin or γ-catenin...
June 20, 2018: Bosnian Journal of Basic Medical Sciences
https://www.readbyqxmd.com/read/29924958/overexpression-of-mir-361-5p-in-triple-negative-breast-cancer-tnbc-inhibits-migration-and-invasion-by-targeting-rqcd1-and-inhibiting-the-egfr-pi3k-akt-pathway
#7
Jianjun Han, Jingjing Yu, Yuna Dai, Jumei Li, Meiyan Guo, Jingzhen Song, Xuefeng Zhou
Triple-negative breast cancer (TNBC) is the leading cause of cancer-related death in women. Previous studies indicated that miR-361-5p was downregulated in breast cancer, however, the exact effect of miR-361-5p on TNBC requires further investigation. In the present study, we investigated whether miR-361-5p can act as a tumor suppressor by targeting required for cell differentiation 1 homolog (RQCD1) and inhibiting epidermal growth factor receptor (EGFR)/phosphoinositide 3-kinase (PI3K)/protein kinase B (Akt) pathway in TNBC...
June 20, 2018: Bosnian Journal of Basic Medical Sciences
https://www.readbyqxmd.com/read/29924962/prognostic-value-of-aldehyde-dehydrogenase-1-aldh1-in-invasive-breast-carcinomas
#8
Hale Demir, Ozgecan Dulgar, Bugra Taygun Gulle, Hande Turna, Sennur Ilvan
Aldehyde dehydrogenase 1 (ALDH1) has been identified as a marker of cancer stem cells in breast cancer (BC). Recent studies showed that ALDH1 expression is correlated with poor prognostic parameters and worse clinical outcome in BC. We evaluated ALDH1 expression by immunohistochemistry in a series of 217 invasive BCs and investigated the correlation between ALDH1 expression and clinicopathological parameters, molecular subtypes (luminal A, luminal B, human epidermal growth factor receptor 2 [HER2] type, and triple-negative BC [TNBC]), and patient survival...
June 11, 2018: Bosnian Journal of Basic Medical Sciences
https://www.readbyqxmd.com/read/29924961/epidermal-growth-factor-egf-promotes-bone-healing-in-surgically-induced-osteonecrosis-of-the-femoral-head-onfh
#9
Ozgur Basal, Tolga Atay, İbrahim Metin Ciris, Yakup Barbaros Baykal
Angiogenic effects of epidermal growth factor (EGF), a potent mitogen, have been demonstrated previously. Moreover, different in vitro studies showed that EGF affects processes associated with bone healing, such as osteoblast differentiation and bone resorption. The aim of this study was to investigate the effect of combined core decompression (CD) and recombinant human EGF (rhEGF) treatment on early-stage osteonecrosis of the femoral head (ONFH) surgically induced in rats. ONFH was induced by dissecting the cervical periosteum and placing a ligature tightly around the femoral neck...
June 11, 2018: Bosnian Journal of Basic Medical Sciences
https://www.readbyqxmd.com/read/29750894/ceftriaxone-treatment-of-complicated-urinary-tract-infections-as-a-risk-factor-for-enterococcal-re-infection-and-prolonged-hospitalization-a-6-year-retrospective-study
#10
Kristian Karlović, Jadranka Nikolić, Jurica Arapović
A frequent complication during hospital stay of patients with urinary tract infections (UTIs) is a re-infection of the urinary tract after the initial improvement. In this study, we investigated the impact of two empirical antibiotic therapies on the outcomes of complicated bacterial UTIs. We retrospectively evaluated 325 adult patients hospitalized during 6 years period with a diagnosis of complicated bacterial UTIs. The patients were classified into two groups according to the antibiotic therapy: ceftriaxone- and co-amoxiclav+gentamicin-treated group...
May 5, 2018: Bosnian Journal of Basic Medical Sciences
https://www.readbyqxmd.com/read/29750895/predictors-and-incidence-of-hospitalization-due-to-respiratory-syncytial-virus-rsv-associated-lower-respiratory-tract-infection-lrti-in-non-prophylaxed-moderate-to-late-preterm-infants-in-bosnia-and-herzegovina
#11
Hajrija Maksić, Suada Heljić, Fahrija Skokić, Darinka Šumanović-Glamuzina, Veroslava Milošević, Almir Zlatanović, Notario Gerard
Prematurity is a risk factor for respiratory syncytial virus (RSV)-associated lower respiratory tract infections (LRTIs), due to immature humoral and cell-mediated immune system in preterm newborns, as well as their incomplete lung development. Palivizumab, a humanized monoclonal antibody against the F glycoprotein of RSV, is licensed for the prevention of severe RSV LRTI in children at high risk for the disease. This study is a part of a larger observational, retrospective-prospective epidemiological study (PONI) conducted at 72 sites across 23 countries in the northern temperate zone...
April 27, 2018: Bosnian Journal of Basic Medical Sciences
https://www.readbyqxmd.com/read/29688163/human-amniotic-fluid-stem-cells-hafscs-expressing-p21-and-cyclin-d1-genes-retain-excellent-viability-after-freezing-with-dimethyl-sulfoxide-dmso
#12
Shiva Gholizadeh-Ghaleh Aziz, Zahra Fardyazar, Fatima Pashaei-Asl, Mohammad Rahmati-Yamchi, Khodadad Khodadadi, Maryam Pashaiasl
Human amniotic fluid stem cells (hAFSCs) have features intermediate between embryonic and adult SCs, can differentiate into lineages of all three germ layers, and do not develop into tumors in vivo. Moreover, hAFSCs can be easily obtained in routine procedures and there is no ethical or legal limitations regarding their use for clinical and experimental applications. The aim of this study was to assess the effect of slow freezing/thawing and two different concentrations of DMSO (10% DMSO + 90% fetal bovine serum [FBS] and 5% DMSO + 95% FBS) on the survival of hAFSCs...
April 24, 2018: Bosnian Journal of Basic Medical Sciences
https://www.readbyqxmd.com/read/29669510/analysis-of-long-non-coding-rna-lncrna-expression-in-hepatitis-b-patients
#13
Sunde Yılmaz Susluer, Cagla Kayabasi, Besra Ozmen Yelken, Aycan Asik, Didem Celik, Tugce Balci Okcanoglu, Suheyla Serin Senger, Cigir Biray Avci, Sukran Kose, Cumhur Gunduz
Long non-coding RNAs (lncRNAs) have been implicated in numerous biological processes, including epigenetic regulation, cell-cycle control, and transcriptional/translational regulation of gene expression. Differential expression of lncRNAs and disruption of the regulatory processes are recognized as critical steps in cancer development. The role of lncRNAs in hepatitis B virus (HBV) infection is not well understood. Here we analyzed the expression of 135 lncRNAs in plasma samples of 82 HBV patients (classified as chronic patients, inactive carriers, or resolved patients) at diagnosis and at 12 months of treatment in relation to control group (81 healthy volunteers)...
May 20, 2018: Bosnian Journal of Basic Medical Sciences
https://www.readbyqxmd.com/read/29659350/does-dental-caries-affect-dental-development-in-children-and-adolescents
#14
Brunilda Dhamo, Besiana Elezi, Lea Kragt, Eppo B Wolvius, Edwin M Ongkosuwito
Although a link between dietary changes, caries, and dental development has been observed, the literature provides little insight about this relationship. The aim of our study was to investigate the association between dental caries and dental development in a clinical sample of Albanian children and adolescents. In total, 118 children and adolescents, born between 1995 and 2004 and aged 6-15 years, were included. Dental caries in the deciduous dentition was assessed using the Decayed, Filled Teeth (dft) index and dental caries in the permanent dentition was assessed using the Decayed, Missing, Filled Teeth (DMFT) index...
May 20, 2018: Bosnian Journal of Basic Medical Sciences
https://www.readbyqxmd.com/read/29659348/evaluation-of-estrogen-and-g-protein-coupled-estrogen-receptor-1-gper-levels-in-drug-na%C3%A3-ve-patients-with-attention-deficit-hyperactivity-disorder-adhd
#15
Nilfer Sahin, Hatice Altun, Ergül Belge Kurutaş, Ebru Fındıklı
Estrogen has a crucial role in the regulation of reproductive and neuroendocrine function and exerts its effects through two classes of receptors, nuclear and membrane estrogen receptors (mERs). G protein-coupled estrogen receptor 1 (GPER) is a member of mERs, and despite limited research on the levels of GPER in patients with psychiatric diseases, a role of GPER in such conditions has been suggested. Here we evaluated serum estrogen and GPER levels in children with attention deficit hyperactivity disorder (ADHD) in relation to their age- and gender-matched healthy controls...
May 20, 2018: Bosnian Journal of Basic Medical Sciences
https://www.readbyqxmd.com/read/29510084/dexmedetomidine-reduces-ventilator-induced-lung-injury-vili-by-inhibiting-toll-like-receptor-4-tlr4-nuclear-factor-nf-%C3%AE%C2%BAb-signaling-pathway
#16
Hongli Chen, Xiaotong Sun, Xiaomei Yang, Yonghao Hou, Xiaoqian Yu, Yang Wang, Jianbo Wu, Dejie Liu, Huanliang Wang, Jingui Yu, Wenbo Yi
Mechanical ventilation (MV) may lead to ventilator-induced lung injury (VILI). Previous research has shown that dexmedetomidine attenuates pulmonary inflammation caused by MV, but the underlying mechanisms remain unclear. Our study aims to test whether dexmedetomidine has a protective effect against VILI and to explore the possible molecular mechanisms using the rat model. Thirty adult male Wistar rats weighing 200-250 g were randomly assigned to 5 groups (n = 6): control, low tidal volume MV (LMV), high tidal volume (HVT) MV (HMV), HVT MV + dexmedetomidine (DEX), HVT MV + dexmedetomidine + yohimbine (DEX+Y)...
May 20, 2018: Bosnian Journal of Basic Medical Sciences
https://www.readbyqxmd.com/read/29389309/standardization-and-optimization-of-fluorescence-in-situ-hybridization-fish-for-her-2-assessment-in-breast-cancer-a-single-center-experience
#17
Magdalena Bogdanovska-Todorovska, Gordana Petrushevska, Vesna Janevska, Liljana Spasevska, Slavica Kostadinova-Kunovska
Accurate assessment of human epidermal growth factor receptor 2 (HER-2) is crucial in selecting patients for targeted therapy. Commonly used methods for HER-2 testing are immunohistochemistry (IHC) and fluorescence in situ hybridization (FISH). Here we presented the implementation, optimization and standardization of two FISH protocols using breast cancer samples and assessed the impact of pre-analytical and analytical factors on HER-2 testing. Formalin fixed paraffin embedded (FFPE) tissue samples from 70 breast cancer patients were tested for HER-2 using PathVysion™ HER-2 DNA Probe Kit and two different paraffin pretreatment kits, Vysis/Abbott Paraffin Pretreatment Reagent Kit (40 samples) and DAKO Histology FISH Accessory Kit (30 samples)...
May 20, 2018: Bosnian Journal of Basic Medical Sciences
https://www.readbyqxmd.com/read/29310566/analysis-of-oxidative-stress-related-markers-in-critically-ill-polytrauma-patients-an-observational-prospective-single-center-study
#18
Mihai Sandesc, Alexandru Florin Rogobete, Ovidiu Horea Bedreag, Anca Dinu, Marius Papurica, Carmen Alina Cradigati, Mirela Sarandan, Sonia Elena Popovici, Lavinia Melania Bratu, Tiberiu Bratu, Adrian Tudor Stan, Dorel Sandesc
Critically ill polytrauma patients have increased production of free radicals (FRs) and consequent alterations in biochemical pathways, as well as disruption of cellular integrity, due to increased lipid peroxidation. The aim of this study was to investigate several biomarkers associated with increased oxidative stress in critically ill polytrauma patients, and to evaluate the effect of antioxidant treatment on the clinical outcome in these patients. A total of 67 polytrauma patients from an intensive care unit met the selection criteria...
May 20, 2018: Bosnian Journal of Basic Medical Sciences
https://www.readbyqxmd.com/read/29236646/evaluation-of-bone-mineral-density-bmd-and-indicators-of-bone-turnover-in-patients-with-hemophilia
#19
Mehmet Dagli, Ali Kutlucan, Sedat Abusoglu, Abdulkadir Basturk, Mehmet Sozen, Leyla Kutlucan, Ali Unlu, Farise Yilmaz
A decrease in bone mass is observed in hemophilic patients. The aim of this study was to evaluate bone mineral density (BMD), parathyroid hormone (PTH), 25-hydroxy vitamin D (vitamin D), and a bone formation and resorption marker, procollagen type I N-terminal propeptide (PINP) and urinary N-terminal telopeptide (uNTX) respectively, in hemophilic patients and healthy controls. Laboratory parameters related to the pathogenesis of bone loss such as neutrophil-lymphocyte ratio (NLR) and platelet-lymphocyte ratio (PLR) were also evaluated...
May 20, 2018: Bosnian Journal of Basic Medical Sciences
https://www.readbyqxmd.com/read/29144891/a-plea-for-an-extension-of-the-anatomical-nomenclature-the-locomotor-system
#20
REVIEW
Vladimir Musil, Alzbeta Blankova, Vaclav Baca
Anatomical nomenclature is the main tool of communication in morphology, anatomy and other medical disciplines as well as in medical education, and thus needs to be exact, flawless, elaborate and correct. The Terminologia Anatomica (TA) is a thorough and extensive list of anatomical terms and their definitions, and the current standard for human anatomical terminology. Although several revisions to the TA have been made in the last 20 years, some important anatomical structures are still not included. This article is aimed at correcting and extending the anatomical nomenclature described in the TA...
May 20, 2018: Bosnian Journal of Basic Medical Sciences
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