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Bosnian Journal of Basic Medical Sciences

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https://www.readbyqxmd.com/read/30242807/prediction-of-breast-cancer-metastasis-risk-using-circulating-tumor-markers-a-follow-up-study
#1
Sibel Cetintas, Gulcin Tezcan, Berrin Tunca, Unal Egeli, Mustafa Sehsuvar Gokgoz, Gulsah Cecener
Distant organ tumor dissemination is a major cause of breast cancer-related deaths. In 2010, we analyzed the prognostic importance of the circulating tumor markers (CTM) cytokeratin (CK)19, CK20, epidermal growth factor receptor (EGFR) and human epidermal growth factor receptor 2 (HER2) in relation to the clinical and pathological characteristics of patients with breast cancer (BC). To assess the clinical utility of CK19, CK20 and EGFR in predicting distant metastasis and recurrence in BC, here we report 7-year follow-up results of 77 patients...
September 17, 2018: Bosnian Journal of Basic Medical Sciences
https://www.readbyqxmd.com/read/30242808/risk-factors-for-complications-and-graft-failure-in-kidney-transplant-patients-with-sepsis
#2
Syuan-Hao Syu, Yung-Wei Lin, Ke-Hsun Lin, Liang-Ming Lee, Chi-Hao Hsiao, Yu-Ching Wen
Immunosuppressive therapies decreased the incidence of acute kidney rejection after kidney transplantation, but also increased the risk of infections and sepsis. This study aimed to identify the risk factors associated with complications and/or graft failure in kidney transplant patients with sepsis. A total of 14,658 kidney transplant patients with sepsis, identified in the National Inpatient Sample (NIS) database (data from 2005-2014), were included in the study and classified into three groups: patients without complications or graft failure/dialysis (Group 1), patients with complications only (Group 2), and patients with complications and graft failure/dialysis (Group 3)...
September 16, 2018: Bosnian Journal of Basic Medical Sciences
https://www.readbyqxmd.com/read/30179586/recent-advances-in-research-on-aspartate-%C3%AE-hydroxylase-asph-in-pancreatic-cancer-a-brief-update
#3
REVIEW
Guofang Hou, Boran Xu, Yanghui Bi, Chuanlin Wu, Beibei Ru, Bei Sun, Xuewei Bai
Pancreatic cancer (PC) is a highly aggressive tumor, often difficult to diagnose and treat. Aspartate β-hydroxylase (ASPH) is a type II transmembrane protein and the member of α-ketoglutarate-dependent dioxygenase family, found to be overexpressed in different cancer types, including PC. ASPH appears to be involved in the regulation of proliferation, invasion and metastasis of PC cells through multiple signaling pathways, suggesting its role as a tumor biomarker and therapeutic target. In this review, we briefly summarize the possible mechanisms of action of ASPH in PC and recent progress in the therapeutic approaches targeting ASPH...
September 3, 2018: Bosnian Journal of Basic Medical Sciences
https://www.readbyqxmd.com/read/30172249/cannabinoids-in-cancer-treatment-therapeutic-potential-and-legislation
#4
REVIEW
Barbara Dariš, Mojca Tancer Verboten, Željko Knez, Polonca Ferk
The plant Cannabis sativa L. has been used as an herbal remedy for centuries and is the most important source of phytocannabinoids. The endocannabinoid system (ECS) consists of receptors, endogenous ligands (endocannabinoids) and metabolizing enzymes, and plays an important role in different physiological and pathological processes. Phytocannabinoids and synthetic cannabinoids can interact with the components of ECS or other cellular pathways and thus affect the development/progression of diseases, including cancer...
September 2, 2018: Bosnian Journal of Basic Medical Sciences
https://www.readbyqxmd.com/read/30172250/induction-of-epithelial-mesenchymal-transition-emt-and-gli1-expression-in-head-and-neck-squamous-cell-carcinoma-hnscc-spheroid-cultures
#5
Nesrine Essid, Jean Claude Chambard, Amel Benammar Elgaaïed
Tumor microenvironment provides a specialized niche in which a population of stem-like cells is enriched and contributes to cancer progression. Moreover, cancer stem cell (CSC) phenotype has been associated with epithelial-mesenchymal transition (EMT). Here we investigated the effect of tumor microenvironment on the phenotypic characteristics of head and neck cancer cells and expression of CSC markers using a three-dimensional (3D), spheroid, culture system of CAL33 cell line from human tongue squamous cell carcinoma...
August 31, 2018: Bosnian Journal of Basic Medical Sciences
https://www.readbyqxmd.com/read/30114377/genetic-secrets-of-long-term-glioblastoma-survivors
#6
REVIEW
Ivana Jovčevska
Glioblastomas account for the majority of primary brain tumors. Although glioblastomas are considered as rare diseases, they represent 60%-70% of all gliomas and in most cases have fatal consequences. Genetic analyses show great heterogeneity both intratumor and intertumor. This notion opens up debates about glioblastoma origin. Different brain cells including astrocytes, neural stem cells, oligodendrocyte precursor cells and glioblastoma stem cells are proposed as capable of initiation and reseeding a tumor; however data is still inconclusive...
August 14, 2018: Bosnian Journal of Basic Medical Sciences
https://www.readbyqxmd.com/read/30114379/dose-fall-off-during-the-treatment-of-thoracic-spine-metastasis-with-cyberknife-stereotactic-body-radiation-therapy-sbrt
#7
Zhongjian Ju, Jingyuan Wang, Huaiwen Zhang, Lei Du, Wei Xu, Xiaoshen Wang, Ruigang Ge, Jiwei Li, Qingzeng Zheng, Jianxiong Li
CyberKnife stereotactic body radiation therapy (SBRT) is becoming increasingly used for cancer treatment and, to maximize its clinical application, it is important to define the dosimetric characteristics, optimal dose and fractionation regimens. The aim of this study was to evaluate the dose fall-off in two fractionated regimens of CyberKnife SBRT during the treatment of thoracic spinal metastasis. Patients with spinal metastasis involving a vertebra and pedicle were treated with 40 Gy in 5 fractions (n = 4), and patients with spinal metastasis involving only a vertebra received 33 Gy in 3 fractions (n = 4)...
August 2, 2018: Bosnian Journal of Basic Medical Sciences
https://www.readbyqxmd.com/read/30114378/downregulation-of-tspan13-by-mir-369-3p-inhibits-cell-proliferation-in-papillary-thyroid-cancer-ptc
#8
Peng Li, Mingqiang Dong, Zhigang Wang
Previous studies demonstrated dysregulation of different microRNAs in thyroid cancer. Tetraspanins (TSPANs) are cell surface proteins with critical roles in many cellular processes, and implications in tumor development. Here we investigated the role of miR-369-3p in papillary thyroid cancer (PTC) and its association with TSPAN13. miR-369-3p and the TSPAN13 gene expression profiles of 513 thyroid cancer and 59 normal thyroid tissues were downloaded from the Cancer Genome Atlas database. Thyroid cancer tissues were classified according to the histological type, grouped based on low and high median miR-369-3p and TSPAN13 expression, and analyzed in relation to overall survival (OS) of patients...
August 2, 2018: Bosnian Journal of Basic Medical Sciences
https://www.readbyqxmd.com/read/30054998/a-plea-for-an-extension-of-the-anatomical-nomenclature-organ-systems
#9
Vladimir Musil, Alzbeta Blankova, Vlasta Dvorakova, Radovan Turyna, Vaclav Baca
This article is the third part of a series aimed at correcting and extending the anatomical nomenclature. Communication in clinical medicine as well as in medical education is extensively composed of anatomical, histological, and embryological terms. Thus, to avoid any confusion, it is essential to have a concise, exact, perfect and correct anatomical nomenclature. The Terminologia Anatomica (TA) was published 20 years ago and during this period several revisions have been made. Nevertheless, some important anatomical structures are still not included in the terminology...
July 23, 2018: Bosnian Journal of Basic Medical Sciences
https://www.readbyqxmd.com/read/30054999/upregulation-of-mir-210-promotes-differentiation-of-mesenchymal-stem-cells-mscs-into-osteoblasts
#10
Ali Asgharzadeh, Shaban Alizadeh, Mohammad Reza Keramati, Masoud Soleimani, Amir Atashi, Mahdi Edalati Fathabad, Zahra Kashani Khatib, Mohammad Rafiee, Mohyedin Barzegar, Hengamehsadat Razavi
Numerous studies indicated that microRNAs are critical in the regulation of cellular differentiation, by controlling the expression of underlying genes. The aim of this study was to investigate the effect of miR-210 upregulation on differentiation of human umbilical cord blood (HUCB)-derived mesenchymal stem cells (MSCs) into osteoblasts. MSCs were isolated from HUCB and confirmed by their adipogenic/osteogenic differentiation and flow cytometric analysis of surface markers. Pre-miR-210 was amplified from human DNA, digested and ligated with plenti-III-mir-green fluorescent protein (GFP) vector, and cloned in STBL4 bacteria...
July 19, 2018: Bosnian Journal of Basic Medical Sciences
https://www.readbyqxmd.com/read/29984678/effects-of-epinephrine-on-heart-rate-variability-and-cytokines-in-a-rat-sepsis-model
#11
Yun-Te Chang, Wei-Chun Huang, Chin-Chang Cheng, Meng-Wei Ke, Jung-Shun Tsai, Yao-Min Hung, Neng-Chyan Huang, Mu-Shun Huang, Shue-Ren Wann
Catecholamines have both anti-inflammatory and vasoactive properties. A decreased cardiac response to catecholamines has been associated with a high risk of death in sepsis and septic shock. The aim of this study was to investigate the effects of epinephrine (EPI) on heart rate variability and autonomic balance, as well as cytokine levels, in a rat sepsis model. Thirty-six male Sprague-Dawley rats were assigned to 4 experimental groups and 2 control groups of 6 rats each. The rats in the experimental groups were inoculated with a lipopolysaccharide (LPS, endotoxin) to establish a sepsis model...
July 7, 2018: Bosnian Journal of Basic Medical Sciences
https://www.readbyqxmd.com/read/29984677/delirium-following-total-joint-replacement-surgery
#12
Jeffrey Huang, Juraj Sprung, Toby N Weingarten
Postoperative delirium (POD) is a common complication associated with increased resource utilization, morbidity and mortality. Our institution screens all postsurgical patients for postoperative delirium. The study aim was to perform an automated interrogation of the electronic health records to estimate the incidence of and identify associated risk factors for POD following total joint arthroplasty (TJA). Adult patients who underwent TJA with a multimodal analgesia protocol, including peripheral nerve blockade, from 2008 through 2012, underwent automated chart review...
July 7, 2018: Bosnian Journal of Basic Medical Sciences
https://www.readbyqxmd.com/read/29984676/simple-reliable-and-time-efficient-colorimetric-method-for-the-assessment-of-mitochondrial-function-and-toxicity
#13
Faraz Ahmad, Widyan Alamoudi, Shafiul Haque, Mohammad Salahuddin, Khaldoon Alsamman
Mitochondria are organelles involved in the production of cellular energy, regulation of Ca2+ and redox signaling, and are critical for normal functioning of eukaryotic cells. The dysfunction of mitochondria has been implicated in a wide range of diseases, including metabolic and neurodegenerative disorders and different types of cancers. To better understand the role of mitochondria in healthy and disease states, the development of efficient and reliable tools for the assessment of mitochondrial function is particularly important...
July 7, 2018: Bosnian Journal of Basic Medical Sciences
https://www.readbyqxmd.com/read/29984679/clinical-features-and-management-of-oral-lichen-planus-olp-with-emphasis-on-the-management-of-hepatitis-c-virus-hcv-related-olp
#14
REVIEW
Alexandru Mester, Ondine Lucaciu, Lidia Ciobanu, Dragos Apostu, Aranka Ilea, Radu Septimiu Campian
Oral lichen planus (OLP) is a chronic inflammatory disease characterized by the occurrence of multiple, symmetrical lesions in the oral cavity. Hepatitis C virus (HCV) infection has been suggested as an etiological factor in OLP. The purpose of this review was to summarize the current literature regarding the treatment of OLP in patients with HCV infection. An electronic search of the PubMed database was conducted until January 2018, using the following keywords: OLP, HCV, corticosteroids, retinoids, immunomodulatory agents, surgical interventions, photochemotherapy, laser therapy, interferon, ribavirin, and direct-acting antivirals...
August 1, 2018: Bosnian Journal of Basic Medical Sciences
https://www.readbyqxmd.com/read/29924959/immunohistochemical-expression-of-nedd9-e-cadherin-and-%C3%AE-catenin-and-their-prognostic-significance-in-pancreatic-ductal-adenocarcinoma-pdac
#15
Petra Radulović, Božo Krušlin
Extensive research is being conducted to identify novel diagnostic, predictive and prognostic biomarkers for pancreatic ductal adenocarcinoma (PDAC), as only a few markers have been routinely used so far with limited success. Our aim was to assess the expression of neural precursor cell expressed developmentally down-regulated protein 9 (NEDD9), E-cadherin, and γ-catenin in PDAC in relation to clinicopathological parameters and patient survival. We also investigated if there is a correlation of NEDD9 expression with E-cadherin or γ-catenin...
August 1, 2018: Bosnian Journal of Basic Medical Sciences
https://www.readbyqxmd.com/read/29750895/predictors-and-incidence-of-hospitalization-due-to-respiratory-syncytial-virus-rsv-associated-lower-respiratory-tract-infection-lrti-in-non-prophylaxed-moderate-to-late-preterm-infants-in-bosnia-and-herzegovina
#16
Hajrija Maksić, Suada Heljić, Fahrija Skokić, Darinka Šumanović-Glamuzina, Veroslava Milošević, Almir Zlatanović, Notario Gerard
Prematurity is a risk factor for respiratory syncytial virus (RSV)-associated lower respiratory tract infections (LRTIs), due to immature humoral and cell-mediated immune system in preterm newborns, as well as their incomplete lung development. Palivizumab, a humanized monoclonal antibody against the F glycoprotein of RSV, is licensed for the prevention of severe RSV LRTI in children at high risk for the disease. This study is a part of a larger observational, retrospective-prospective epidemiological study (PONI) conducted at 72 sites across 23 countries in the northern temperate zone...
August 1, 2018: Bosnian Journal of Basic Medical Sciences
https://www.readbyqxmd.com/read/29671719/immune-cells-and-vasa-vasorum-in-the-tunica-media-of-atherosclerotic-coronary-arteries
#17
Ruda Zorc-Pleskovič, Aleš Pleskovič, Olga Vraspir-Porenta, Metka Zorc, Aleksandra Milutinović
In coronary artery disease (CAD), the disruption of the tunica media immune privilege manifests as increased leukocyte infiltration and the formation of vasa vasorum. We aimed to characterize the immune privilege status of the tunica media in human coronary arteries (CAs) with atherosclerotic plaques, by comparing the abundance and composition of immune-cell infiltrates within the individual arterial-wall layers, and by evaluating vasa vasorum neovascularization of the tunica media. The tissue samples were obtained from 36 symptomatic patients with diffuse CAD (aged 60-72 years) who underwent coronary endarterectomy...
August 1, 2018: Bosnian Journal of Basic Medical Sciences
https://www.readbyqxmd.com/read/29669235/histological-observations-on-adipocere-in-human-remains-buried-for-21-years-at-the-toma%C3%A5-ica-grave-site-in-bosnia-and-herzegovina
#18
Adis Salihbegović, John Clark, Nermin Sarajlić, Svjetlana Radović, Finlay Finlay, Anes Jogunčić, Emina Spahić, Vedo Tuco
The Tomašica grave-site near Prijedor in the north of Bosnia is reported to be the largest primary mass grave discovered thus far relating to the 1992-95 war. A total of 275 complete bodies and 125 body parts were exhumed from it in 2013. Post mortem examinations of the victims showed that nearly all had died from gunshot injuries but an additional striking feature was the degree of preservation of many of the bodies, even 21 years on, with skin, soft tissues and internal organs still present in abundance and gross structures clearly identifiable...
August 1, 2018: Bosnian Journal of Basic Medical Sciences
https://www.readbyqxmd.com/read/29659349/control-of-body-temperature-and-immune-function-in-patients-undergoing-open-surgery-for-gastric-cancer
#19
Li Shao, Nannan Pang, Ping Yan, Fengju Jia, Qi Sun, Wenjuan Ma, Yi Yang
The influence of mild perioperative hypothermia on the immune function and incidence of postoperative wound infections has been suggested, but the specific mechanism is unclear. This study aimed to analyze the body temperature, immune function, and wound infection rates in patients receiving open surgery for gastric cancer. Body temperature was controlled in each patient using one of four different methods: wrapping limbs, head and neck; insulated blankets; warming infusion fluids and insulated blankets; and warming fluids without insulated blankets...
August 1, 2018: Bosnian Journal of Basic Medical Sciences
https://www.readbyqxmd.com/read/29579408/analysis-of-the-association-between-cfh-y402h-polymorphism-and-response-to-intravitreal-ranibizumab-in-patients-with-neovascular-age-related-macular-degeneration-namd
#20
Nur Afiqah Mohamad, Vasudevan Ramachandran, Patimah Ismail, Hazlita Mohd Isa, Yoke Mun Chan, Nor Fariza Ngah, Norshakimah Md Bakri, Siew Mooi Ching, Fan Kee Hoo, Wan Aliaa Wan Sulaiman, Liyana Najwa Inche Mat, Mohd Hazmi Mohamed
Pharmacogenetic studies indicate that a variable response to anti-vascular endothelial growth factor (VEGF) therapy in patients with neovascular form of AMD (nAMD) may be due to polymorphisms in the complement factor H gene (CFH). This study is the first to investigate the association between CFH Y402H polymorphism and the response to ranibizumab therapy in Malaysian patients with nAMD. We included 134 patients with nAMD, examined between September 2014 and February 2016. The diagnosis of nAMD was confirmed by ophthalmologic examination, before ranibizumab therapy was started...
August 1, 2018: Bosnian Journal of Basic Medical Sciences
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