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Bioinorganic Chemistry and Applications

María Del Carmen Sánchez-Navarro, Claudio Adrian Ruiz-Torres, Nereyda Niño-Martínez, Roberto Sánchez-Sánchez, Gabriel Alejandro Martínez-Castañón, I DeAlba-Montero, Facundo Ruiz
Nanomaterials obtained by green synthesis technologies have been widely studied in recent years owing to constitute cost-effective and environmental-friendly methods. In addition, there are several works that report the simultaneous performance of the reducer agent as a functionalizing agent, modifying the properties of the nanomaterial. As a simple and economical synthesis methodology, this work presents a method to synthesize silver nanoparticles (AgNPs) using Annona muricata aqueous extract and functionalized with 5-fluorouracil (5-FU)...
2018: Bioinorganic Chemistry and Applications
Xuejiao Li, Yahong Liu, Hongqi Tian
To overcome the side effects of and resistance to cisplatin, a variety of Pt(IV) prodrugs were designed and synthesized via different modifications including combination with lipid chains to increase hydrophobicity, conjugation with short peptide chains or nanoparticles to improve drug delivery, or addition of bioactive ligands to the axial positions of Pt(IV) complexes to exert dual-function effects. This review summarizes the recent progress in the development of Pt(IV) prodrugs conjugated with bioactive-targeting ligands, including histone deacetylase inhibitors, p53 agonists, alkylating agents, and nonsteroidal anti-inflammatory agents...
2018: Bioinorganic Chemistry and Applications
Gamil A Al-Hazmi, Khlood S Abou-Melha, Nashwa M El-Metwaly, Kamel A Saleh
A series of perimidine derivatives (L1-5 ) were prepared and characterized by IR, 1 H·NMR, mass spectroscopy, UV-Vis, XRD, thermal, and SEM analysis. Five VO(II) complexes were synthesized and investigated by most previous tools besides the theoretical usage. A neutral tetradentate mode of bonding is the general approach for all binding ligands towards bi-vanadyl atoms. A square-pyramidal is the configuration proposed for all complexes. XRD analysis introduces the nanocrystalline nature of the ligand while the amorphous appearance of its metal ion complexes...
2018: Bioinorganic Chemistry and Applications
Ghadah M Al-Senani, Foziah F Al-Fawzan
Wild herbs ( Origanum ( OR ) and Lavandula ( LV )) were used as environment-friendly adsorbents in this study. The adsorbents were used for adsorption of Cu and Ba from water. The adsorption of heavy metals onto OR and LV was dependent on particle size, dose, and solution pH. The diameter of adsorbent particles was less than 282.8 nm. The adsorption follows second-order kinetics. Langmuir and Freundlich models have been applied to describe the equilibrium data, and the thermodynamic parameters, the Gibbs free energy, ∆ G °, enthalpy, ∆ H °, and entropy, ∆ S °, have been determined...
2018: Bioinorganic Chemistry and Applications
Kaila F Hart, Natalie S Joe, Rebecca M Miller, Hannah P Nash, David J Blake, Aimee M Morris
Numerous therapies for the treatment of cancer have been explored with increasing evidence that the use of metal-containing compounds could prove advantageous as anticancer therapeutics. Previous works on Ru(III) complexes suggest that structurally similar Co(III) complexes may provide good alternative, low-cost, effective prodrugs. Herein, a new complex, trans -[Co(imidazole)4 Cl2 ]Cl ( 2 ), has been synthesized in high yields utilizing ligand exchange under refluxing conditions. The structure of 2 has been characterized by elemental analysis, 1 H and 13 C·NMR, ESI-MS, CV, and UV-Vis...
2018: Bioinorganic Chemistry and Applications
Supun Katugampala, Inoka C Perera, Chandrika Nanayakkara, Theshini Perera
Metallotriazine complexes possess interesting biological and medicinal properties, and the present study focuses on the synthesis, characterization, and antimicrobial activity of four novel copper-triazine derivatives in search of potent antibacterial and antifungal drug leads. In this study, 3-(2-pyridyl)-5,6-diphenyl-1,2,4-triazine-4,4'-disulfonic acid monosodium salt (L1, ferrozine) and 3-(2-pyridyl)-5,6-di(2-furyl)-1,2,4-triazine-5,5'-disulfonic acid disodium salt (L2, ferene) have been used as ligands to study the complexation towards copper(II)...
2018: Bioinorganic Chemistry and Applications
Aiten Ismailova, David Kuter, D Scott Bohle, Ian S Butler
Carbon monoxide (CO) has long been known as the "silent killer" owing to its ability to form carboxyhemoglobin-the main cause of CO poisoning in humans. Its role as an endogenous neurotransmitter, however, was suggested in the early 1990s. Since then, the biological activity of CO has been widely examined via both the direct administration of CO and in the form of so-called "carbon monoxide releasing molecules (CORMs)." This overview will explore the general physiological effects and potential therapeutic applications of CO when delivered in the form of CORMs...
2018: Bioinorganic Chemistry and Applications
Abdullah-Al Masum, Yosuke Hisamatsu, Kenta Yokoi, Shin Aoki
Death receptors (DR4 and DR5) offer attractive targets for cancer treatment because cancer cell death can be induced by apoptotic signal upon binding of death ligands such as tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) with death receptors. Cyclometalated iridium(III) complexes such as fac -Ir(tpy)3 (tpy = 2-(4-tolyl)pyridine) possess a C 3 -symmetric structure like TRAIL and exhibit excellent luminescence properties. Therefore, cyclometalated Ir complexes functionalized with DR-binding peptide motifs would be potent TRAIL mimics to detect cancer cells and induce their cell death...
2018: Bioinorganic Chemistry and Applications
V N Kalpana, V Devi Rajeswari
The advance of reliable and eco-friendly strategies for the development of nanoparticles is a fundamental key to the discipline of nanotechnology. Nanoparticles have been continuously evaluated and have been used in many industrial applications for a decade. In particular, the role of zinc oxide nanoparticles (ZnO NPs) has received a great interest because of various properties such as UV filter properties and photochemical, antifungal, high catalyst, and antimicrobial activities. Because of the high rate of poisonous chemicals and the extreme surroundings used within the chemical and physical methods, the green techniques have been adopted using plants, fungi, bacteria, and algae for the synthesis of nanoparticles...
2018: Bioinorganic Chemistry and Applications
Ilaria Gamba
The development of artificial photosynthetic technologies able to produce solar-fuels from CO2 reduction is a fundamental task that requires the employment of specific catalysts being accomplished. Besides, effective catalysts are also demanded to capture atmospheric CO2 , mitigating the effects of its constantly increasing emission. Biomimetic transition metal complexes are considered ideal platforms to develop efficient and selective catalysts to be implemented in electrocatalytic and photocatalytic devices...
2018: Bioinorganic Chemistry and Applications
Zbigniew Dutkiewicz, Renata Mikstacka
Cytochromes P450 are a class of metalloproteins which are responsible for electron transfer in a wide spectrum of reactions including metabolic biotransformation of endogenous and exogenous substrates. The superfamily of cytochromes P450 consists of families and subfamilies which are characterized by a specific structure and substrate specificity. Cytochromes P450 family 1 (CYP1s) play a distinctive role in the metabolism of drugs and chemical procarcinogens. In recent decades, these hemoproteins have been intensively studied with the use of computational methods which have been recently developed remarkably to be used in the process of drug design by the virtual screening of compounds in order to find agents with desired properties...
2018: Bioinorganic Chemistry and Applications
Atakilt Abebe, Minaleshewa Atlabachew, Misganaw Liyew, Elsabet Ferede
New organic salts were synthesized by quaternizing 1,10-phenanthroline using 1-bromotetradecane. The first step yielded an organic salt of formula [C26 H37 N2 ]Br. Anion exchange reaction using Li[(CF3 SO2 )2 N] resulted in a more stable salt of formula [C26 H37 N2 ][(CF3 SO2 )2 N]. The organic salts were investigated by spectrometry (1 H, 13 C, 19 F NMR, X-ray photoelectron spectroscopy (XPS), UV-Vis, and matrix-assisted laser desorption/ionization mass spectroscopy (MALDI MS), CHNSBr elemental analysis, and thermal analysis (TGA and DSC)...
2018: Bioinorganic Chemistry and Applications
Peiran Zhao, Shanshan Zhai, Jianfang Dong, Lei Gao, Xinru Liu, Lei Wang, Jinming Kong, Lianzhi Li
Three hexacoordinated octahedral nickel(II) complexes, [Ni(sal-L-phe)(phen)(CH3 OH)]·CH3 OH ( 1 ), [Ni(naph-L-phe)(phen)(CH3 OH)] ( 2 ), and [Ni( o -van-L-phe)(phen)(CH3 OH)]·5CH3 OH ( 3 ) (sal-L-phe = a Schiff base derived from salicylaldehyde and L-phenylalanine, naph-L-phe = a Schiff base derived from 2-hydroxy-1-naphthaldehyde and L-phenylalanine, o -van-L-phe = a Schiff base derived from o -vanillin and L-phenylalanine, and phen = 1,10-phenanthroline), have been synthesized and characterized by elemental analysis, IR spectra, and single-crystal X-ray diffraction...
2018: Bioinorganic Chemistry and Applications
Jinhuan Jiang, Jiang Pi, Jiye Cai
Zinc oxide nanoparticles (ZnO NPs) are used in an increasing number of industrial products such as rubber, paint, coating, and cosmetics. In the past two decades, ZnO NPs have become one of the most popular metal oxide nanoparticles in biological applications due to their excellent biocompatibility, economic, and low toxicity. ZnO NPs have emerged a promising potential in biomedicine, especially in the fields of anticancer and antibacterial fields, which are involved with their potent ability to trigger excess reactive oxygen species (ROS) production, release zinc ions, and induce cell apoptosis...
2018: Bioinorganic Chemistry and Applications
Fozia Batool, Jamshed Akbar, Shahid Iqbal, Sobia Noreen, Syed Nasir Abbas Bukhari
Reports about presence and toxicity of Cd2+ in different chemical industrial effluents prompted the researchers to explore some economical, rapid, sensitive, and accurate methods for its determination and removal from aqueous systems. In continuation of series of investigations, adsorption of Cd2+ onto the stem of Saccharum arundinaceum is proposed in the present work. Optimization of parameters affecting sorption potential of Cd2+ including pH, contact time, temperature, sorbent dose, and concentration of sorbate was carried out to determine best suited conditions for maximum removal of sorbate...
2018: Bioinorganic Chemistry and Applications
Shalaka S Rokade, Komal A Joshi, Ketakee Mahajan, Saniya Patil, Geetanjali Tomar, Dnyanesh S Dubal, Vijay Singh Parihar, Rohini Kitture, Jayesh R Bellare, Sougata Ghosh
Green chemistry approaches for designing therapeutically significant nanomedicine have gained considerable attention in the past decade. Herein, we report for the first time on anticancer potential of phytogenic platinum nanoparticles (PtNPs) and palladium nanoparticles (PdNPs) using a medicinal plant Gloriosa superba tuber extract (GSTE). The synthesis of the nanoparticles was completed within 5 hours at 100°C which was confirmed by development of dark brown and black colour for PtNPs and PdNPs, respectively, along with enhancement of the peak intensity in the UV-visible spectra...
2018: Bioinorganic Chemistry and Applications
M Manjushree, Hosakere D Revanasiddappa
The binding interaction between bovine serum albumin (BSA) and sodium salt of risedronic acid (RSN) was studied by using the FT-IR (Fourier transform infrared), UV-Vis (ultraviolet-visible), fluorescence (emission and synchronous), CD (circular dichroism) spectrometric, and computational (molecular docking) techniques at 289, 297, and 305 K temperatures with physiological buffer of pH 7.40. The conformational and secondary structural changes observed for BSA from CD spectra and by curve fitting procedure were applied to Fourier self-deconvolution in FT-IR spectra...
2018: Bioinorganic Chemistry and Applications
K Savithri, H D Revanasiddappa
Two novel oxidovanadium(IV) complexes with a new bidentate (O- and N-) imine-based ligand 2-((E)-(6-fluorobenzo[d]thiazol-2-ylimino)methyl)-6-methoxyphenol (HL) were synthesized under in situ experimental condition where VOSO4 acts as a kinetic template in the ratio 2 : 1 (L : M) and mixed ligand complex using 1,10-phenanthroline (phen) in 1 : 1 : 1 (L : M : phen) ratio. The synthesized compounds were structurally characterized by microanalysis, magnetic susceptibility, FTIR, electronic spectra, TG/DTA, ESR, and molar conductance studies...
2018: Bioinorganic Chemistry and Applications
J Christian Léon, Linda Stegemann, Martin Peterlechner, Stefanie Litau, Gerhard Wilde, Cristian A Strassert, Jens Müller
[This corrects the article DOI: 10.1155/2016/7485125.].
2018: Bioinorganic Chemistry and Applications
Samuel Treviño, Alfonso Díaz, Eduardo Sánchez-Lara, Víctor Enrique Sarmiento-Ortega, José Ángel Flores-Hernández, Eduardo Brambila, Francisco J Meléndez, Enrique González-Vergara
Vanadium(IV/V) compounds have been studied as possible metallopharmaceutical drugs against diabetes mellitus. However, mechanisms of action and toxicological threshold have been tackled poorly so far. In this paper, our purposes were to evaluate the metabolic activity on dyslipidemia and dysglycemia, insulin signaling in liver and adipose tissue, and toxicology of the title compound. To do so, the previously reported bisammonium tetrakis 4-( N , N -dimethylamino)pyridinium decavanadate, the formula of which is [DMAPH]4 (NH4 )2 [V10 O28 ]·8H2 O (where DMAPH is 4-dimethylaminopyridinium ion), was synthesized, and its dose-response curve on hyperglycemic rats was evaluated...
2018: Bioinorganic Chemistry and Applications
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