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Bioinorganic Chemistry and Applications

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https://www.readbyqxmd.com/read/27847444/synthesis-characterization-and-biological-studies-of-a-piperidinyl-appended-dipicolylamine-ligand-and-its-rhenium-tricarbonyl-complex-as-potential-therapeutic-agents-for-human-breast-cancer
#1
Amali Subasinghe, Inoka C Perera, Svetlana Pakhomova, Theshini Perera
A novel ligand bearing a central piperidinyl sulfonamide group, N(SO2pip)dpa, and its corresponding Re tricarbonyl complex, [Re(CO)3(N(SO2pip)dpa)](+), have been synthesized in good yield. The methylene CH2 signal seen as a singlet (4.54 ppm) in a (1)H NMR spectrum of the ligand in DMSO-d6 appears as two doublets (5.39, 5.01 ppm) in a spectrum of the [Re(CO)3(N(SO2pip)dpa)](+) complex and confirms the presence of magnetically nonequivalent protons upon coordination to Re. Structural results revealed that the Re-N bond lengths fall within the normal range establishing coordination of ligand to metal...
2016: Bioinorganic Chemistry and Applications
https://www.readbyqxmd.com/read/27833473/synthesis-and-assessment-of-antibacterial-activities-of-ruthenium-iii-mixed-ligand-complexes-containing-1-10-phenanthroline-and-guanide
#2
Atakilt Abebe, Tizazu Hailemariam
In this work, two complexes of ruthenium(III) ([Ru(phen)2Cl2]Cl·2H2O and [Ru(phen)2(G)Cl]2Cl·H2O) were synthesized from 1,10-phenanthroline alone as well as from both 1,10-phenanthroline and guanide. The synthesis was checked using halide test, conductance measurement, and spectroscopic (ICP-OES, FTIR, and UV/Vis) analysis. Their in vitro antibacterial activities were also investigated on two Gram-positive (Staphylococcus aureus (S. aureus) and methicillin resistant Staphylococcus aureus (MRSA)) and two Gram-negative (Escherichia coli (E...
2016: Bioinorganic Chemistry and Applications
https://www.readbyqxmd.com/read/27803644/gamma-radiation-induced-damage-in-the-zinc-finger-of-the-transcription-factor-iiia
#3
XiaoHong Zhang, YuJi Miao, XiaoDan Hu, Rui Min, PeiDang Liu, HaiQian Zhang
A zinc finger motif is an element of proteins that can specifically recognize and bind to DNA. Because they contain multiple cysteine residues, zinc finger motifs possess redox properties. Ionizing radiation generates a variety of free radicals in organisms. Zinc finger motifs, therefore, may be a target of ionizing radiation. The effect of gamma radiation on the zinc finger motifs in transcription factor IIIA (TFIIIA), a zinc finger protein, was investigated. TFIIIA was exposed to different gamma doses from (60)Co sources...
2016: Bioinorganic Chemistry and Applications
https://www.readbyqxmd.com/read/27774044/structural-and-antioxidant-properties-of-compounds-obtained-from-fe-2-chelation-by-juglone-and-two-of-its-derivatives-dft-qtaim-and-nbo-studies
#4
Aymard Didier Tamafo Fouegue, Julius Numbonui Ghogomu, Désiré Bikélé Mama, Nyiang Kennet Nkungli, Elie Younang
The chelating ability of juglone and two of its derivatives towards Fe(2+)ion and the antioxidant activity (AOA) of the resulting chelates and complexes (in the presence of H2O and CH3OH as ligands) in gas phase is reported via bond dissociation enthalpy, ionization potential, proton dissociation enthalpy, proton affinity, and electron transfer enthalpy. The DFT/B3LYP level of theory associated with the 6-31+G(d,p) and 6-31G(d) Pople-style basis sets on the atoms of the ligands and the central Fe(II), respectively, was used...
2016: Bioinorganic Chemistry and Applications
https://www.readbyqxmd.com/read/27774043/polyanionic-biopolymers-for-the-delivery-of-pt-ii-cationic-antiproliferative-complexes
#5
Mauro Ravera, Elisabetta Gabano, Ilaria Zanellato, Elena Perin, Aldo Arrais, Domenico Osella
Phenanthriplatin, that is, (SP-4-3)-diamminechlorido(phenanthridine)platinum(II) nitrate, an effective antitumor cationic Pt(II) complex, was loaded on negatively charged dextran sulfate (DS) as a model vector for drug delivery via electrostatic interactions. The free complex and the corresponding conjugate with DS were tested on two standard human tumor cell lines, namely, ovarian A2780 and colon HCT 116, and on several malignant pleural mesothelioma cell lines (namely, epithelioid BR95, mixed/biphasic MG06, sarcomatoid MM98, and sarcomatoid cisplatin-resistant MM98R)...
2016: Bioinorganic Chemistry and Applications
https://www.readbyqxmd.com/read/27738409/chemical-species-micromorphology-and-xrd-fingerprint-analysis-of-tibetan-medicine-zuotai-containing-mercury
#6
Cen Li, Hongxia Yang, Yuzhi Du, Yuancan Xiao, Zhandui, Sanglao, Zhang Wang, Duojie Ladan, Hongtao Bi, Lixin Wei
Zuotai (gTso thal) is one of the famous drugs containing mercury in Tibetan medicine. However, little is known about the chemical substance basis of its pharmacodynamics and the intrinsic link of different samples sources so far. Given this, energy dispersive spectrometry of X-ray (EDX), scanning electron microscopy (SEM), atomic force microscopy (AFM), and powder X-ray diffraction (XRD) were used to assay the elements, micromorphology, and phase composition of nine Zuotai samples from different regions, respectively; the XRD fingerprint features of Zuotai were analyzed by multivariate statistical analysis...
2016: Bioinorganic Chemistry and Applications
https://www.readbyqxmd.com/read/27698647/novel-fe-ii-and-co-ii-complexes-of-natural-product-tryptanthrin-synthesis-and-binding-with-g-quadruplex-dna
#7
Yi-Ning Zhong, Yan Zhang, Yun-Qiong Gu, Shi-Yun Wu, Wen-Ying Shen, Ming-Xiong Tan
Tryptanthrin is one of the most important members of indoloquinoline alkaloids. We obtained this alkaloid from Isatis. Two novel Fe(II) and Co(II) complexes of tryptanthrin were first synthesized. Single-crystal X-ray diffraction analyses show that these complexes display distorted four-coordinated tetrahedron geometry via two heterocyclic nitrogen and oxygen atoms from tryptanthrin ligand. Binding with G-quadruplex DNA properties revealed that both complexes were found to exhibit significant interaction with G-quadruplex DNA...
2016: Bioinorganic Chemistry and Applications
https://www.readbyqxmd.com/read/27660601/effect-of-ag-addition-on-the-electrochemical-performance-of-cu10al-in-artificial-saliva
#8
R J Salgado-Salgado, J Porcayo-Calderon, O Sotelo-Mazon, R A Rodriguez-Diaz, G Salinas-Solano, V M Salinas-Bravo, L Martinez-Gomez
In this work we proposed to evaluate the corrosion resistance of four different alloys by electrochemical techniques, a binary alloy Cu10Al, and three ternary alloys Cu10Al-xAg (x = 5, 10, and 15 wt.%) to be used like biomaterials in dental application. Biomaterials proposed were tested in artificial saliva at 37°C for 48 h. In addition, pure metals Cu, Al, Ag, and Ti as reference materials were evaluated. In general the short time tests indicated that the Ag addition increases the corrosion resistance and reduces the extent of localized attack of the binary alloy...
2016: Bioinorganic Chemistry and Applications
https://www.readbyqxmd.com/read/27648004/reversible-oxygenation-of-2-4-diaminobutanoic-acid-co-ii-complexes
#9
Xiang Cheng, Yan Huang, Hui Li, Fan Yue, Hongmei Wen, Jide Wang
This paper introduces the structural characterization and studies on reversible oxygenation behavior of a new oxygen carrier Co(II)-2,4-diaminobutanoic acid (DABA) complex in aqueous solution. The composition of the oxygenated complex was determined by gas volumetric method, molar ratio method, and mass spectrometry, and the formula of the oxygenated complex was determined to be [Co(DABA)2O2]. In aqueous solution, the complex can continuously uptake and release dioxygen and exhibit excellent reversibility of oxygenation and deoxygenation ability...
2016: Bioinorganic Chemistry and Applications
https://www.readbyqxmd.com/read/27597814/synthesis-characterization-anticancer-and-antioxidant-studies-of-ru-iii-complexes-of-monobasic-tridentate-schiff-bases
#10
Ikechukwu P Ejidike, Peter A Ajibade
Mononuclear Ru(III) complexes of the type [Ru(LL)Cl2(H2O)] (LL = monobasic tridentate Schiff base anion: (1Z)-N'-(2-{(E)-[1-(2,4-dihydroxyphenyl)ethylidene]amino}ethyl)-N-phenylethanimidamide [DAE], 4-[(1E)-N-{2-[(Z)-(4-hydroxy-3-methoxybenzylidene)amino]ethyl}ethanimidoyl]benzene-1,3-diol [HME], 4-[(1E)-N-{2-[(Z)-(3,4-dimethoxybenzylidene)amino]ethyl}ethanimidoyl]benzene-1,3-diol [MBE], and N-(2-{(E)-[1-(2,4-dihydroxyphenyl)ethylidene]amino}ethyl)benzenecarboximidoyl chloride [DEE]) were synthesized and characterized using the microanalytical, conductivity measurements, electronic spectra, and FTIR spectroscopy...
2016: Bioinorganic Chemistry and Applications
https://www.readbyqxmd.com/read/27524954/effect-of-his-tag-on-expression-purification-and-structure-of-zinc-finger-protein-znf191-243-368
#11
Dongxin Zhao, Zhongxian Huang
Zinc finger proteins are associated with hereditary diseases and cancers. To obtain an adequate amount of zinc finger proteins for studying their properties, structure, and functions, many protein expression systems are used. ZNF191(243-368) is a zinc finger protein and can be fused with His-tag to generate fusion proteins such as His6-ZNF191(243-368) and ZNF191(243-368)-His8. The purification of His-tag protein using Ni-NTA resin can overcome the difficulty of ZNF191(243-368) separation caused by inclusion body formation...
2016: Bioinorganic Chemistry and Applications
https://www.readbyqxmd.com/read/27478426/synthesis-of-polydopamine-functionalized-reduced-graphene-oxide-palladium-nanocomposite-for-laccase-based-biosensor
#12
Da-Wei Li, Lei Luo, Peng-Fei Lv, Qing-Qing Wang, Ke-Yu Lu, An-Fang Wei, Qu-Fu Wei
Graphene based 2D nanomaterials have attracted increasing attention in biosensing application due to the outstanding physicochemical properties of graphene. In this work, palladium nanoparticles (Pd) loaded reduced graphene oxide (rGO) hybrid (rGO-Pd) was synthesized through a facile method. Laccase (Lac) was immobilized on rGO-Pd by utilizing the self-polymerization of dopamine, which generated polydopamine (PDA). The PDA-Lac-rGO-Pd nanocomposites were further modified on electrode surface to construct novel biosensing platform...
2016: Bioinorganic Chemistry and Applications
https://www.readbyqxmd.com/read/27436993/a-novel-application-of-ti-substituted-polyoxometalates-anti-inflammatory-activity-in-ova-induced-asthma-murine-model
#13
Dong Li, Xiuzhu Gao, Jingmin Gu, Yuan Tian, Yaqing Liu, Zheng Jin, Dongmei Yan, Ya-Guang Chen, Xun Zhu
Objective. Asthma is a chronic inflammatory disorder. Despite extensive researches into the treatment and management of it, current treatments and management strategies are still limited. The search for a novel approach to its treatments is urgently needed. Researches on the potential medical use of polyoxometalates (POMs) have already shown it has antiviral and antitumor bioactivities. But the effects of POM in immune systems are still largely unknown. Methods. In order to investigate the role of POM in the asthmatic disease, we used OVA-induced asthma murine model and observed the pathological changes between mice that received three different Ti-substituted POMs (0...
2016: Bioinorganic Chemistry and Applications
https://www.readbyqxmd.com/read/27382364/spectral-studies-of-uv-and-solar-photocatalytic-degradation-of-azo-dye-and-textile-dye-effluents-using-green-synthesized-silver-nanoparticles
#14
R Mariselvam, A J A Ranjitsingh, P Mosae Selvakumar, Abdullah A Alarfaj, Murugan A Munusamy
The photocatalytic degradation of the chemical dye AZO and dye effluents in different time duration has been investigated using biologically synthesized silver nanoparticles. Dye industry effluents and AZO dye undergo degradation to form harmless intermediate and colourless products following irradiation by UV and solar light in the presence of green synthesized silver nanoparticles. The degree of degradation was tested under the experimental conditions such as P(H), temperature, and absorbance of the dye in UV and solar light was measured...
2016: Bioinorganic Chemistry and Applications
https://www.readbyqxmd.com/read/27127456/hair-mercury-levels-detection-in-fishermen-from-sicily-italy-by-icp-ms-method-after-microwave-assisted-digestion
#15
Giuseppe Giangrosso, Gaetano Cammilleri, Andrea Macaluso, Antonio Vella, Nicolantonio D'Orazio, Stefania Graci, Gianluigi Maria Lo Dico, Fabio Galvano, Margherita Giangrosso, Vincenzo Ferrantelli
A number of ninety-six hair samples from Sicilian fishermen were examined for total mercury detection by an Inductively Coupled Plasma Mass Spectrometry (ICP-MS) method. The mercury levels obtained were compared with mercury levels of 96 hair samples from a control group, in order to assess potential exposure to heavy metals of Sicilian fishermen due to fish consumption and closeness to industrial activities. Furthermore, the mercury levels obtained from hair samples were sorted by sampling area in order to verify the possible risks linked to the different locations...
2016: Bioinorganic Chemistry and Applications
https://www.readbyqxmd.com/read/27034627/formation-of-silver-nanoclusters-from-a-dna-template-containing-ag-i-mediated-base-pairs
#16
J Christian Léon, Linda Stegemann, Martin Peterlechner, Stefanie Litau, Gerhard Wilde, Cristian A Strassert, Jens Müller
A series of DNA double helices containing different numbers of silver(I)-mediated base pairs involving the artificial nucleobases imidazole or 2-methylimidazole has been applied for the generation of DNA-templated silver nanoclusters. The original Ag(I)-containing nucleic acids as well as the resulting nanoclusters and nanoparticles have been characterized by means of UV/Vis spectroscopy, circular dichroism (CD) spectroscopy, fluorescence spectroscopy, and transmission electron microscopy (TEM). The results show for the first time that metal-mediated base pairs can be used for the templated growth of metal nanoclusters...
2016: Bioinorganic Chemistry and Applications
https://www.readbyqxmd.com/read/27022316/reversible-oxygenation-of-%C3%AE-amino-acid-cobalt-ii-complexes
#17
Xincun Zhang, Fan Yue, Hui Li, Yan Huang, Yi Zhang, Hongmei Wen, Jide Wang
We systematically investigated the reversibility, time lapse, and oxygenation-deoxygenation properties of 15 natural α-amino acid-Co(II) complexes through UV-vis spectrophotometer, polarographic oxygen electrode, and DFT calculations, respectively, to explore the relationship between the coordinating structure and reversible oxygenation of α-amino acid-Co(II) complexes. Results revealed that the α-amino acid structure plays a key role in the reversible oxygenation properties of these complexes. The specific configuration of the α-amino acid group affects the eg (1) electron of Co(II) transfer to the π (⁎) orbit of O2; this phenomenon also favors the reversible formation and dissociation of Co-O2 bond when O2 coordinates with Co(II) complexes...
2016: Bioinorganic Chemistry and Applications
https://www.readbyqxmd.com/read/26977141/effects-of-osseointegration-by-bone-morphogenetic-protein-2-on-titanium-implants-in-vitro-and-in-vivo
#18
Fu-Yuan Teng, Wen-Cheng Chen, Yin-Lai Wang, Chun-Cheng Hung, Chun-Chieh Tseng
This study designed a biomimetic implant for reducing healing time and achieving early osseointegration to create an active surface. Bone morphogenetic protein-2 (BMP-2) is a strong regulator protein in osteogenic pathways. Due to hardly maintaining BMP-2 biological function and specificity, BMP-2 efficient delivery on implant surfaces is the main challenge for the clinic application. In this study, a novel method for synthesizing functionalized silane film for superior modification with BMP-2 on titanium surfaces is proposed...
2016: Bioinorganic Chemistry and Applications
https://www.readbyqxmd.com/read/26977140/synthesis-crystal-structure-spectroscopic-properties-and-interaction-with-ct-dna-of-zn-ii-with-2-aminoethanethiol-hydrochloride-ligand
#19
Xu-Gang Shu, Chun-Li Wu, Cui-Jin Li, Min Zhang, Ke Wan, Xin Wu
The zinc(II) complex (C2H6NS)2Zn·ZnCl2 was synthesized with 2-aminoethanethiol hydrochloride and zinc sulfate heptahydrate as the raw materials in aqueous solution. The composition and structure of the complex were characterized by elemental analysis, infrared spectra, single crystal X-ray diffraction, and thermogravimetry. The crystal structure of the zinc(II) complex belongs to monoclinic system, space group P  21/n, with cell parameters of a = 0.84294(4), b = 0.83920(4), c = 1.65787(8) nm, Z = 2, and D = 2...
2016: Bioinorganic Chemistry and Applications
https://www.readbyqxmd.com/read/26924953/norfloxacin-and-n-donor-mixed-ligand-copper-ii-complexes-synthesis-albumin-interaction-and-anti-trypanosoma-cruzi-activity
#20
Darliane A Martins, Ligiane R Gouvea, Gabriel S Vignoli Muniz, Sonia R W Louro, Denise da Gama Jaen Batista, Maria de Nazaré C Soeiro, Letícia R Teixeira
Copper(II) complexes with the first-generation quinolone antibacterial agent norfloxacin containing a nitrogen donor heterocyclic ligand 2,2'-bipyridine (bipy) or 1,10-phenanthroline (phen) were prepared and characterized by IR, EPR spectra, molar conductivity, and elemental analyses. The experimental data suggest that norfloxacin was coordinated to copper(II) through the carboxylato and ketone oxygen atoms. The interaction of the copper(II) complexes with bovine serum albumin (BSA) and human serum albumin (HSA) was investigated using fluorescence quenching of the tryptophan residues and copper(II) EPR spectroscopy...
2016: Bioinorganic Chemistry and Applications
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