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Bioinorganic Chemistry and Applications

Aiten Ismailova, David Kuter, D Scott Bohle, Ian S Butler
Carbon monoxide (CO) has long been known as the "silent killer" owing to its ability to form carboxyhemoglobin-the main cause of CO poisoning in humans. Its role as an endogenous neurotransmitter, however, was suggested in the early 1990s. Since then, the biological activity of CO has been widely examined via both the direct administration of CO and in the form of so-called "carbon monoxide releasing molecules (CORMs)." This overview will explore the general physiological effects and potential therapeutic applications of CO when delivered in the form of CORMs...
2018: Bioinorganic Chemistry and Applications
Abdullah-Al Masum, Yosuke Hisamatsu, Kenta Yokoi, Shin Aoki
Death receptors (DR4 and DR5) offer attractive targets for cancer treatment because cancer cell death can be induced by apoptotic signal upon binding of death ligands such as tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) with death receptors. Cyclometalated iridium(III) complexes such as fac -Ir(tpy)3 (tpy = 2-(4-tolyl)pyridine) possess a C 3 -symmetric structure like TRAIL and exhibit excellent luminescence properties. Therefore, cyclometalated Ir complexes functionalized with DR-binding peptide motifs would be potent TRAIL mimics to detect cancer cells and induce their cell death...
2018: Bioinorganic Chemistry and Applications
V N Kalpana, V Devi Rajeswari
The advance of reliable and eco-friendly strategies for the development of nanoparticles is a fundamental key to the discipline of nanotechnology. Nanoparticles have been continuously evaluated and have been used in many industrial applications for a decade. In particular, the role of zinc oxide nanoparticles (ZnO NPs) has received a great interest because of various properties such as UV filter properties and photochemical, antifungal, high catalyst, and antimicrobial activities. Because of the high rate of poisonous chemicals and the extreme surroundings used within the chemical and physical methods, the green techniques have been adopted using plants, fungi, bacteria, and algae for the synthesis of nanoparticles...
2018: Bioinorganic Chemistry and Applications
Ilaria Gamba
The development of artificial photosynthetic technologies able to produce solar-fuels from CO2 reduction is a fundamental task that requires the employment of specific catalysts being accomplished. Besides, effective catalysts are also demanded to capture atmospheric CO2 , mitigating the effects of its constantly increasing emission. Biomimetic transition metal complexes are considered ideal platforms to develop efficient and selective catalysts to be implemented in electrocatalytic and photocatalytic devices...
2018: Bioinorganic Chemistry and Applications
Zbigniew Dutkiewicz, Renata Mikstacka
Cytochromes P450 are a class of metalloproteins which are responsible for electron transfer in a wide spectrum of reactions including metabolic biotransformation of endogenous and exogenous substrates. The superfamily of cytochromes P450 consists of families and subfamilies which are characterized by a specific structure and substrate specificity. Cytochromes P450 family 1 (CYP1s) play a distinctive role in the metabolism of drugs and chemical procarcinogens. In recent decades, these hemoproteins have been intensively studied with the use of computational methods which have been recently developed remarkably to be used in the process of drug design by the virtual screening of compounds in order to find agents with desired properties...
2018: Bioinorganic Chemistry and Applications
Atakilt Abebe, Minaleshewa Atlabachew, Misganaw Liyew, Elsabet Ferede
New organic salts were synthesized by quaternizing 1,10-phenanthroline using 1-bromotetradecane. The first step yielded an organic salt of formula [C26 H37 N2 ]Br. Anion exchange reaction using Li[(CF3 SO2 )2 N] resulted in a more stable salt of formula [C26 H37 N2 ][(CF3 SO2 )2 N]. The organic salts were investigated by spectrometry (1 H, 13 C, 19 F NMR, X-ray photoelectron spectroscopy (XPS), UV-Vis, and matrix-assisted laser desorption/ionization mass spectroscopy (MALDI MS), CHNSBr elemental analysis, and thermal analysis (TGA and DSC)...
2018: Bioinorganic Chemistry and Applications
Peiran Zhao, Shanshan Zhai, Jianfang Dong, Lei Gao, Xinru Liu, Lei Wang, Jinming Kong, Lianzhi Li
Three hexacoordinated octahedral nickel(II) complexes, [Ni(sal-L-phe)(phen)(CH3 OH)]·CH3 OH ( 1 ), [Ni(naph-L-phe)(phen)(CH3 OH)] ( 2 ), and [Ni( o -van-L-phe)(phen)(CH3 OH)]·5CH3 OH ( 3 ) (sal-L-phe = a Schiff base derived from salicylaldehyde and L-phenylalanine, naph-L-phe = a Schiff base derived from 2-hydroxy-1-naphthaldehyde and L-phenylalanine, o -van-L-phe = a Schiff base derived from o -vanillin and L-phenylalanine, and phen = 1,10-phenanthroline), have been synthesized and characterized by elemental analysis, IR spectra, and single-crystal X-ray diffraction...
2018: Bioinorganic Chemistry and Applications
Jinhuan Jiang, Jiang Pi, Jiye Cai
Zinc oxide nanoparticles (ZnO NPs) are used in an increasing number of industrial products such as rubber, paint, coating, and cosmetics. In the past two decades, ZnO NPs have become one of the most popular metal oxide nanoparticles in biological applications due to their excellent biocompatibility, economic, and low toxicity. ZnO NPs have emerged a promising potential in biomedicine, especially in the fields of anticancer and antibacterial fields, which are involved with their potent ability to trigger excess reactive oxygen species (ROS) production, release zinc ions, and induce cell apoptosis...
2018: Bioinorganic Chemistry and Applications
Fozia Batool, Jamshed Akbar, Shahid Iqbal, Sobia Noreen, Syed Nasir Abbas Bukhari
Reports about presence and toxicity of Cd2+ in different chemical industrial effluents prompted the researchers to explore some economical, rapid, sensitive, and accurate methods for its determination and removal from aqueous systems. In continuation of series of investigations, adsorption of Cd2+ onto the stem of Saccharum arundinaceum is proposed in the present work. Optimization of parameters affecting sorption potential of Cd2+ including pH, contact time, temperature, sorbent dose, and concentration of sorbate was carried out to determine best suited conditions for maximum removal of sorbate...
2018: Bioinorganic Chemistry and Applications
Shalaka S Rokade, Komal A Joshi, Ketakee Mahajan, Saniya Patil, Geetanjali Tomar, Dnyanesh S Dubal, Vijay Singh Parihar, Rohini Kitture, Jayesh R Bellare, Sougata Ghosh
Green chemistry approaches for designing therapeutically significant nanomedicine have gained considerable attention in the past decade. Herein, we report for the first time on anticancer potential of phytogenic platinum nanoparticles (PtNPs) and palladium nanoparticles (PdNPs) using a medicinal plant Gloriosa superba tuber extract (GSTE). The synthesis of the nanoparticles was completed within 5 hours at 100°C which was confirmed by development of dark brown and black colour for PtNPs and PdNPs, respectively, along with enhancement of the peak intensity in the UV-visible spectra...
2018: Bioinorganic Chemistry and Applications
M Manjushree, Hosakere D Revanasiddappa
The binding interaction between bovine serum albumin (BSA) and sodium salt of risedronic acid (RSN) was studied by using the FT-IR (Fourier transform infrared), UV-Vis (ultraviolet-visible), fluorescence (emission and synchronous), CD (circular dichroism) spectrometric, and computational (molecular docking) techniques at 289, 297, and 305 K temperatures with physiological buffer of pH 7.40. The conformational and secondary structural changes observed for BSA from CD spectra and by curve fitting procedure were applied to Fourier self-deconvolution in FT-IR spectra...
2018: Bioinorganic Chemistry and Applications
K Savithri, H D Revanasiddappa
Two novel oxidovanadium(IV) complexes with a new bidentate (O- and N-) imine-based ligand 2-((E)-(6-fluorobenzo[d]thiazol-2-ylimino)methyl)-6-methoxyphenol (HL) were synthesized under in situ experimental condition where VOSO4 acts as a kinetic template in the ratio 2 : 1 (L : M) and mixed ligand complex using 1,10-phenanthroline (phen) in 1 : 1 : 1 (L : M : phen) ratio. The synthesized compounds were structurally characterized by microanalysis, magnetic susceptibility, FTIR, electronic spectra, TG/DTA, ESR, and molar conductance studies...
2018: Bioinorganic Chemistry and Applications
J Christian Léon, Linda Stegemann, Martin Peterlechner, Stefanie Litau, Gerhard Wilde, Cristian A Strassert, Jens Müller
[This corrects the article DOI: 10.1155/2016/7485125.].
2018: Bioinorganic Chemistry and Applications
Samuel Treviño, Alfonso Díaz, Eduardo Sánchez-Lara, Víctor Enrique Sarmiento-Ortega, José Ángel Flores-Hernández, Eduardo Brambila, Francisco J Meléndez, Enrique González-Vergara
Vanadium(IV/V) compounds have been studied as possible metallopharmaceutical drugs against diabetes mellitus. However, mechanisms of action and toxicological threshold have been tackled poorly so far. In this paper, our purposes were to evaluate the metabolic activity on dyslipidemia and dysglycemia, insulin signaling in liver and adipose tissue, and toxicology of the title compound. To do so, the previously reported bisammonium tetrakis 4-( N , N -dimethylamino)pyridinium decavanadate, the formula of which is [DMAPH]4 (NH4 )2 [V10 O28 ]·8H2 O (where DMAPH is 4-dimethylaminopyridinium ion), was synthesized, and its dose-response curve on hyperglycemic rats was evaluated...
2018: Bioinorganic Chemistry and Applications
Jiaqi Mai, Yunlan Li, Xiaozhi Qiao, Xiaoqing Ji, Qingshan Li
Diorganotin(IV) antitumor compound bis-[2,6-difluoro- N -(hydroxyl-<κ> O )benzamidato-<κ> O ] (DBDF2,6T) was one of the novel patent organotin compounds with high antitumor activity and relatively low toxicity. In this study, several methods were used to study the interaction between DBDF2,6T and hPPAR γ protein, including fluorescence quenching, three-dimensional (3D) fluorescence, drug affinity responsive target stability (DARTS), ultrafiltration-LC, and molecular docking. According to the experimental results, the quenching process of the hPPAR γ protein was induced by static quenching mode to form a nonradiative ground-state complex with DBDF2,6T spontaneously, mainly through the hydrophobic force...
2018: Bioinorganic Chemistry and Applications
Adebayo A Adeniyi, Peter A Ajibade
The anticancer study of nitrogen-chelating ligands can be of tremendous help in choosing ligands for the anticancer metal complexes design especially with ruthenium(II). The inhibitory anticancer activities of some nitrogen-chelating ligands containing bis-pyrazole, bipyridine, and phenanthroline were studied using experimental screening against cancer cell and theoretical docking methods. In vitro anticancer activities showed compound 11 as the most promising inhibitor, and the computational docking further indicates its strong inhibitory activities towards some cancer-related receptors...
2018: Bioinorganic Chemistry and Applications
Ting Liu, Yi-An Wang, Qing Zang, Guo-Qing Zhong
A Cu(II) complex [Cu(bipy)(H2 O)2 (SO4 )] n (bipy = 2,2'-bipyridine) was synthesized by hydrothermal method and characterized structurally by elemental analyses, single crystal X-ray diffraction, infrared spectra, and thermogravimetry and differential scanning calorimetry. The Cu(II) was hexacoordinated by two N atoms from bipy, two O atoms from different sulfate radical anions, and two O atoms from two water molecules, forming a slightly distorted octahedral geometry, and bridged by sulfato groups into polymeric chains...
2018: Bioinorganic Chemistry and Applications
Gühergül Uluçam, Murat Turkyilmaz
Four newly synthesized imidazolium salts were characterized by nuclear magnetic resonance, vibrational spectra, and mass spectra. Then, the density functional theory calculations were performed to obtain the molecular configurations on which the theoretical nuclear magnetic resonance and infrared spectra were consequently obtained. The comparison of calculated spectra with the experimental spectra for each molecule leads to the conclusion that the theoretical results can be assumed to be a good approach to their molecular configurations...
2018: Bioinorganic Chemistry and Applications
Samuel Tetteh
The interaction between nickel (Ni2+ ), copper (Cu2+ ), and zinc (Zn2+ ) ions and 1-methylimidazole has been studied by exploring the geometries of eleven crystal structures in the Cambridge Structural Database (CSD). The coordination behavior of the respective ions was further investigated by means of density functional theory (DFT) methods. The gas-phase complexes were fully optimized using B3LYP/GENECP functionals with 6-31G∗ and LANL2DZ basis sets. The Ni2+ and Cu2+ complexes show distorted tetrahedral geometries around the central ions, with Zn2+ being a perfect tetrahedron...
2018: Bioinorganic Chemistry and Applications
Ismail Althagafi, Nashwa M El-Metwaly, Marwa G Elghalban, Thoraya A Farghaly, Abdalla M Khedr
Four pyrazolone derivatives and their corresponding silver complexes were synthesized and characterized. Based on elemental analysis, 1 : 2 (M : L) molar ratio was suggested for all inspected complexes. 1 H, 13 C NMR, mass, UV-Vis, TGA, and IR were the spectral tools used for describing the formulae. Moreover, XRD patterns and SEM pictures were used to evaluate the particle sizes which appeared strongly in nanometer range. CT-DNA study is the major consideration in this study, to test the interacting ability of all synthesized cationic complexes towards cell DNA...
2018: Bioinorganic Chemistry and Applications
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