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Heart Rhythm: the Official Journal of the Heart Rhythm Society

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https://www.readbyqxmd.com/read/29330130/perioperative-electrophysiology-study-in-tetralogy-of-fallot-patients-undergoing-pulmonary-valve-replacement-will-identify-those-at-high-risk-for-subsequent-ventricular-tachycardia
#1
Amneet Sandhu, Emily Ruckdeschel, William H Sauer, Kathryn K Collins, Joseph Kay, Amber Khanna, James Jaggers, David Campbell, Max Mitchell, Duy T Nguyen
BACKGROUND: Ventricular tachyarrhythmias (VAs) are the most common cause of death in patients with repaired Tetralogy of Fallot (TOF), but predicting those at risk remains a challenge. Electrophysiological study (EPS) has been proposed to risk stratify TOF patients. OBJECTIVE: We sought to evaluate a perioperative EPS-guided approach to risk stratify TOF patients undergoing PVR and guide concomitant cryoablation. METHODS: A prospective cohort study of TOF patients undergoing EPS at time of PVR from 2006-present was conducted at 2 centers...
January 9, 2018: Heart Rhythm: the Official Journal of the Heart Rhythm Society
https://www.readbyqxmd.com/read/29330129/estradiol-up-regulates-l-type-ca2-channels-via-membrane-bound-estrogen-receptor-phosphoinositide-3kinase-akt-camp-response-element-binding-protein-signaling-pathway
#2
Xiaoyan Yang, Xiaofang Mao, Gao Xu, Shasha Xing, Ansuman Chattopadhyay, Si Jin, Guy Salama
BACKGROUND: In long QT type-2 (LQT2), women are more prone to lethal arrhythmias called Torsade de Pointes (TdP) than men. We previously reported that 17-β-estradiol (E2) upregulates L-type Ca2+-channels and current (ICa,L) (∼30%) in rabbit ventricular myocytes by a classical genomic-mechanism mediated by estrogen-receptor-α (ER)α. In LQT2 ( IKr-blockade or bradycardia), the higher Ca2+ influx via ICa,L, causes Ca2+-overload, spontaneous sarcoplasmic reticulum Ca2+-release, and re-activation of ICa,L that trigger early afterdepolarizations (EADs) and TdP...
January 9, 2018: Heart Rhythm: the Official Journal of the Heart Rhythm Society
https://www.readbyqxmd.com/read/29330128/exploiting-ion-channel-structure-to-assess-rare-variant-pathogenicity
#3
Brett M Kroncke, Tao Yang, Prince Kannankeril, M Benjamin Shoemaker, Dan M Roden
BACKGROUND: A 27-year-old female was seen for long QT syndrome. She was found to be a carrier of two variants, KCNQ1 Val162Met and KCNH2 Ser55Leu, and both were annotated as pathogenic by a diagnostic laboratory in part because of sequence proximity to other known pathogenic variants. OBJECTIVE: To assess the relationship between both the KCNQ1 and KCNH2 variants and clinical significance using protein structure, in vitro functional assays, and familial segregation...
January 9, 2018: Heart Rhythm: the Official Journal of the Heart Rhythm Society
https://www.readbyqxmd.com/read/29325978/management-of-cardiac-implantable-electronic-devices-in-the-presence-of-left-ventricular-assist-devices
#4
Valay Parikh, Andrew Sauer, Paul Friedman, Seth H Sheldon
Left ventricular assist devices (LVAD) are increasingly utilized in the management of patients with advanced heart failure. Many of these patients have or will be considered for cardiac implantable electronic devices (CIEDs) such as an implantable cardioverter-defibrillator or cardiac resynchronization therapy device. Frequent interplay is often encountered due to complexity of these devices and the underlying disease states. Proactive management strategies and an awareness of interactions may help reduce adverse events...
January 8, 2018: Heart Rhythm: the Official Journal of the Heart Rhythm Society
https://www.readbyqxmd.com/read/29325977/role-of-apamin-sensitive-small-conductance-calcium-activated-potassium-currents-in-long-term-cardiac-memory-in-rabbits
#5
Dechun Yin, Mu Chen, Na Yang, Adonis Z Wu, Dongzhu Xu, Wei-Chung Tsai, Yuan Yuan, Zhipeng Tian, Yi-Hsin Chan, Changyu Shen, Zhenhui Chen, Shien-Fong Lin, James N Weiss, Peng-Sheng Chen, Thomas H Everett
BACKGROUND: Apamin-sensitive small conductance calcium-activated K current (IKAS) is upregulated during ventricular pacing and masks short-term cardiac memory (CM). OBJECTIVE: - To determine the role of IKAS in long-term CM. METHODS: - CM was created with 3-5 weeks of ventricular pacing and defined by a flat or inverted T-wave off pacing. Epicardial optical mapping was performed in both paced and normal ventricles. Action potential duration (APD80) was determined during RA pacing...
January 8, 2018: Heart Rhythm: the Official Journal of the Heart Rhythm Society
https://www.readbyqxmd.com/read/29325976/profile-of-brugada-syndrome-patients-presenting-with-their-first-documented-arrhythmic-event-data-from-the-survey-on-arrhythmic-events-in-brugada-syndrome-sabrus
#6
Anat Milman, Antoine Andorin, Jean-Baptiste Gourraud, Pieter G Postema, Frederic Sacher, Philippe Mabo, Sung-Hwan Kim, Jimmy Jm Juang, Shingo Maeda, Yoshihide Takahashi, Tsukasa Kamakura, Takeshi Aiba, Giulio Conte, Georgia Sarquella-Brugada, Eran Leshem, Michael Rahkovich, Aviram Hochstadt, Yuka Mizusawa, Elena Arbelo, Zhengrong Huang, Isabelle Denjoy, Carla Giustetto, Yanushi D Wijeyeratne, Carlo Napolitano, Yoav Michowitz, Ramon Brugada, Ruben Casado-Arroyo, Jean Champagne, Leonardo Calo, Jacob Tfelt-Hansen, Silvia G Priori, Masahiko Takagi, Christian Veltmann, Pietro Delise, Domenico Corrado, Elijah R Behr, Fiorenzo Gaita, Gan-Xin Yan, Josep Brugada, Antoine Leenhardt, Arthur A M Wilde, Pedro Brugada, Kengo F Kusano, Kenzo Hirao, Gi-Byoung Nam, Vincent Probst, Bernard Belhassen
BACKGROUND: Detailed information on the profile of Brugada syndrome (BrS) patients presenting their first arrhythmic event (AE) after prophylactic implantation of a cardioverter defibrillator (ICD) is limited. OBJECTIVES: 1) To compare clinical, electrocardiographic, electrophysiologic and genetic profiles of patients who exhibited their first documented AE as aborted cardiac arrest (CA) (group A) with those in whom the AE was documented after prophylactic ICD implantation (group B); 2) To characterize group B patients' profile using the Class II indications for ICD implantation established by HRS/EHRA/APHRS Expert Consensus Statement in 2013...
January 8, 2018: Heart Rhythm: the Official Journal of the Heart Rhythm Society
https://www.readbyqxmd.com/read/29325975/procedural-outcomes-and-long-term-survival-associated-with-lead-extraction-in-patients-with-abandoned-leads
#7
Faisal M Merchant, Thor Tejada, Adarsh Patel, Jad El-Khalil, Yaanik Desai, Brent Keeling, Omar M Lattouf, Angel R Leon, Mikhael F El-Chami
BACKGROUND: The decision to abandon or extract superfluous sterile leads is controversial. OBJECTIVE: To compare procedural outcomes and long-term survival of patients with and without abandoned leads undergoing lead extraction (LE). METHODS: Retrospective review of all patients undergoing transvenous LE at our institution from Jan. 2007 to May 2016. Patients were stratified into two groups based on the presence (Group 1) or absence (Group 2) of abandoned leads...
January 8, 2018: Heart Rhythm: the Official Journal of the Heart Rhythm Society
https://www.readbyqxmd.com/read/29325974/fast-nonclinical-ventricular-tachycardia-inducible-after-ablation-in-patients-with-structural-heart-disease-definition-and-clinical-implications
#8
Masaya Watanabe, Marta de Riva, Sebastiaan R D Piers, Olaf M Dekkers, Micaela Ebert, Jeroen Venlet, Serge A Trines, Martin J Schalij, Daniël A Pijnappels, Katja Zeppenfeld
BACKGROUND: Noninducibility of ventricular tachycardia (VT) with an equal or longer cycle length (CL) than the clinical VT is considered the minimum ablation endpoint in patients with structural heart disease (SHD). Since their clinical relevance remains unclear, fast nonclinical VTs are often not targeted. However, an accepted definition for fast VT is lacking. The shortest possible CL of a monomorphic reentrant VT is determined by the ventricular refractory period (VRP). OBJECTIVES: We propose a patient-specific definition for fast VT based on the individual VRP (fVTVRP) and assess the prognostic significance of persistent inducibility after ablation of fVTVRP for VT recurrence...
January 8, 2018: Heart Rhythm: the Official Journal of the Heart Rhythm Society
https://www.readbyqxmd.com/read/29325973/cardiac-electronic-implantable-devices-after-tricuspid-valve-surgery
#9
Raphaël P Martins, Vincent Galand, Christophe Leclercq, Jean-Claude Daubert
The demand for tricuspid valve (TV) surgery has increased continuously these last years. Recent registry data have confirmed that TV repair or replacement carry an increased risk of conduction disorders requiring permanent pacemaker implantation, specifically for patients having multivalve surgery. The implantation of an endocardial right ventricular lead in those patients may impair TV function, and some other approaches may be discussed to avoid traversing the valve. This contemporary review describes the different options currently available for patients requiring pacemaker or defibrillation leads implantation after TV surgery...
January 8, 2018: Heart Rhythm: the Official Journal of the Heart Rhythm Society
https://www.readbyqxmd.com/read/29317317/the-phenotype-is-equally-important-in-promoting-variants-from-benign-to-pathogenic-as-well-as-in-demoting-variants-from-pathogenic-to-benign
#10
EDITORIAL
Ahmad S Amin, Arthur A M Wilde
No abstract text is available yet for this article.
January 6, 2018: Heart Rhythm: the Official Journal of the Heart Rhythm Society
https://www.readbyqxmd.com/read/29317316/thirty-day-readmissions-after-cardiac-implantable-electronic-devices-in-the-united-states-insights-from-the-nationwide-readmissions-database
#11
Brijesh Patel, Naveen Sablani, Jalaj Garg, Rahul Chaudhary, Mahek Shah, Rahul Gupta, Talha Nazir, Babak Bozorgnia, Santosh K Padala, Sampath Gunda, Kenneth A Ellenbogen
BACKGROUND: Limited data are available regarding true estimates of individual complications contributing to readmissions after cardiac implantable electronic device (CIED) implantation. OBJECTIVE: We aimed to identify predictors of 30-day readmission in patients admitted for CIED implantation. METHODS: The study cohort consisted of patients who received CIED implantation in 2014, identified from National Readmission Database. Readmission was defined as a subsequent hospital admission within 30 days after discharge day of index admission...
January 6, 2018: Heart Rhythm: the Official Journal of the Heart Rhythm Society
https://www.readbyqxmd.com/read/29309840/lights-on-can-visual-light-help-distinguish-fibrotic-scars-from-ablation-lesions
#12
EDITORIAL
Anuradha Kalyanasundaram, Vadim V Fedorov
No abstract text is available yet for this article.
January 5, 2018: Heart Rhythm: the Official Journal of the Heart Rhythm Society
https://www.readbyqxmd.com/read/29309839/predictors-of-ecg-screening-failure-for-the-subcutaneous-implantable-cardioverter-defibrillator-in-children-a-prospective-multi-center-study
#13
Matthew Campbell, Jeremy P Moore, Narayanswami Sreeram, Johannes C von Alvensleben, Anjan Shah, Anjan Batra, Ian Law, Shubhayan Sanatani, Vincent Thomas, Farnoosh Nik-Ahd, Stephen Williams, Nina Nosavan, Jennifer Maldonado, Amelia Hart, Thuan Nguyen, Seshadri Balaji
BACKGROUND: Subcutaneous Implantable Cardioverter Defibrillator (SICD) shows promise for select patients at risk for sudden death. However, patients need to pass an ECG screening (ECG-S) test before they can receive an SICD. Predictors of ECG-S failure in children are unclear. OBJECTIVE: To identify the incidence and predictive factors for failure of ECG-S in children. METHODS: Children ≤18 years with a pre-existing ICD underwent SICD ECG-S...
January 5, 2018: Heart Rhythm: the Official Journal of the Heart Rhythm Society
https://www.readbyqxmd.com/read/29288035/clinical-impact-of-an-additional-left-ventricular-lead-in-cardiac-resynchronization-non-responders-the-v3-trial
#14
Pierre Bordachar, Daniel Gras, Nicolas Clementy, Pascal Defaye, Pierre Mondoly, Serge Boveda, Frederic Anselme, PhD, Didier Klug, Olivier Piot, Nicolas Sadoul, Dominique Babuty, Christophe Leclercq
BACKGROUND: Cardiac resynchronization therapy (CRT) is an effective treatment of heart failure (HF), but is limited by a substantial proportion of non-responders. We hypothesized that adding a second left ventricular (LV) lead to deliver a triple site CRT (V3 CRT) may improve clinical status of CRT non-responders. OBJECTIVE: We assessed the feasibility and safety of adding a second LV lead to CRT non-responders and its clinical impact. METHODS: 84 patients recipients of a CRT system and considered as non-responders as per Clinical Composite Score (CCS) were enrolled in this multi-center study...
December 26, 2017: Heart Rhythm: the Official Journal of the Heart Rhythm Society
https://www.readbyqxmd.com/read/29288034/structural-and-functional-remodelling-of-the-atrioventricular-node-with-ageing-in-rats-the-role-of-hyperpolarization-activated-cyclic-nucleotide-gated-and-ryanodine-2-channels
#15
Yawer Saeed, Ian Temple, Zoltan Borbas, Andrew Atkinson, Joseph Yanni, Michal Maczewski, Urszula Mackiewicz, Mariam Aly, Sunil J R J Logantha, Clifford Garratt, Halina Dobrzynski
BACKGROUND: Ageing is associated with an increased incidence of atrioventricular nodal (AVN) dysfunction. OBJECTIVES: The aim of the study is to identify the structural and functional remodelling in the atrioventricular junction (AVJ) with ageing. METHODS: Electrophysiological, histology and immunohistochemistry experiments on male Wistar-Hanover rats aged 3months (n=24) and 2years (n=15) were performed. AH interval, Wenkebach cycle length (WBCL) and AVN effective refractory period (AVNERP) were measured...
December 26, 2017: Heart Rhythm: the Official Journal of the Heart Rhythm Society
https://www.readbyqxmd.com/read/29277687/defibrillator-shocks-and-their-impact-on-objective-and-subjective-patient-outcomes-results-from-the-painfree-sst-clinical-trial
#16
Samuel F Sears, Lindsey Rosman, Shingo Sasaki, Yusuke Kondo, Laurence D Sterns, Edward J Schloss, Takashi Kurita, Albert Meijer, Judith Raijmakers, Bart Gerritse, Angelo Auricchio
BACKGROUND: The impact of ICD shock on device-measured activity and patient reported outcomes is unknown. OBJECTIVE: The purpose of this study was to analyze the acute and long-term effects of ICD shock on objective behavioral data (i.e., device-based physical activity) and subjective patient reported outcomes (e.g., quality of life and shock anxiety). METHODS: The PainFree SST clinical trial included 2,770 patients with a single or dual-chamber ICD, or cardiac resynchronization defibrillator (CRT-D) who were followed for 22 ± 9 months...
December 22, 2017: Heart Rhythm: the Official Journal of the Heart Rhythm Society
https://www.readbyqxmd.com/read/29277686/accurate-localization-and-catheter-ablation-of-superoparaseptal-accessory-pathways
#17
Qiang Liu, Michael Shehata, David Z Lan, Ashkan Ehdaie, Eugenio Cingolani, Sumeet S Chugh, Guosheng Fu, Chenyang Jiang, Xunzhang Wang
BACKGROUND: There remains some confusion delineating the accurate location and the detailed anatomic relationship between atrioventricular accessory pathways (APs) located in the superoparaseptal region. OBJECTIVE: To detail the anatomic relationship and accurate location of APs located in the superoparaseptal region. METHODS: Between 2009 and 2016, 11 patients with superoparaseptal accessory pathways (SPS-APs) were identified in 129 consecutive patients who underwent catheter ablation for APs in our center...
December 22, 2017: Heart Rhythm: the Official Journal of the Heart Rhythm Society
https://www.readbyqxmd.com/read/29277685/cardiac-rhythm-and-pacemaking-abnormalities-in-patients-affected-by-endemic-pemphigus-in-colombia-may-be-a-result-of-deposition-of-autoantibodies-complement-fibrinogen-and-other-molecules
#18
Ana Maria Abreu Velez, Michael S Howard, Jorge Enrique Velazquez-Velez
BACKGROUND: We showed that one third of the patients affected by endemic pemphigus foliaceus in El Bagre, Colombia (El Bagre-EPF) display autoreactivity to the heart. OBJECTIVE: We aim to investigate rhythm disturbances with presence of autoantibodies and correlate them with electrocardiographic changes in these patients. METHODS: We performed a study comparing 30 patients and 30 controls from the endemic area, matched by demographics including age, sex and weight; work activities, comorbidities, among other variables...
December 22, 2017: Heart Rhythm: the Official Journal of the Heart Rhythm Society
https://www.readbyqxmd.com/read/29274474/permanent-his-bundle-pacing-long-term-lead-performance-and-clinical-outcomes
#19
Pugazhendhi Vijayaraman, Angela Naperkowski, Faiz A Subzposh, Mohamed Abdelrahman, Parikshit S Sharma, Jess W Oren, Gopi Dandamudi, Kenneth A Ellenbogen
BACKGROUND: Right ventricular pacing (RVP) is associated with heart failure and increased mortality. His bundle pacing (HBP) is a physiological alternative to RVP. OBJECTIVE: The aim of our study is to report long-term performance and compare the clinical outcomes of permanent HBP to RVP. METHODS: All patients requiring pacemaker implantation underwent attempt at permanent HBP in 2011 at one hospital and RV pacing at the sister hospital. Patients were followed from implantation, 2 weeks, 2 months and yearly for 5 years...
December 20, 2017: Heart Rhythm: the Official Journal of the Heart Rhythm Society
https://www.readbyqxmd.com/read/29248564/el20-a-potent-antiarrhythmic-compound-selectively-inhibits-calmodulin-deficient-ryanodine-receptor-type-2
#20
Robert C Klipp, Na Li, Qiongling Wang, Tarah A Word, Martha Sibrian-Vazquez, Robert M Strongin, Xander H T Wehrens, Jonathan J Abramson
BACKGROUND: Catecholaminergic polymorphic ventricular tachycardia (CPVT) is an arrhythmogenic disorder caused by mutations in the cardiac ryanodine receptor (RyR2) that increase diastolic Ca2+ leak from the sarcoplasmic reticulum (SR). Calmodulin (CaM) dissociation from RyR2 has been associated with diastolic Ca2+ leak in heart failure. OBJECTIVE: Determine if tetracaine-derivative, EL20, inhibits abnormal Ca2+ release from RyR2 in a CPVT model and the underlying mechanism of inhibition...
December 14, 2017: Heart Rhythm: the Official Journal of the Heart Rhythm Society
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