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Heart Rhythm: the Official Journal of the Heart Rhythm Society

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https://www.readbyqxmd.com/read/28438723/long-term-outcomes-of-minimally-invasive-surgical-ablation-for-atrial-fibrillation-a-single-center-experience
#1
Aditya Saini, Yuhning L Hu, Vigneshwar Kasirajan, Frederick T Han, Muhammad Z Khan, Luke Wolfe, Sampath Gunda, Jayanthi N Koneru, Kenneth A Ellenbogen
BACKGROUND: Minimally invasive surgical AF ablation delivers RF energy via a thoracoscopic approach to perform pulmonary vein isolation and LA ganglionic plexi ablation. Data on long term outcomes of MISAA is lacking. OBJECTIVE: We report 5 year follow-up data from a prospective cohort of patients who underwent MISAA at a single center. METHODS: One hundred nine consecutive patients (60 paroxysmal, 49 persistent, mean age 62.7±9.3 years) underwent MISAA with left atrial appendage exclusion by a single surgeon between 2006 and 2012...
April 21, 2017: Heart Rhythm: the Official Journal of the Heart Rhythm Society
https://www.readbyqxmd.com/read/28438722/propagation-of-meandering-rotors-surrounded-by-high-dominant-frequency-areas-in-persistent-atrial-fibrillation
#2
João Salinet, Fernando S Schlindwein, Peter Stafford, Tiago P Almeida, Xin Li, Frederique J Vanheusden, María S Guillem, G André Ng
BACKGROUND: identification of arrhythmogenic regions remains a challenge in persistent atrial fibrillation (persAF). Frequency and phase analysis allows identification of potential ablation targets. OBJECTIVE: This study aims to investigate the spatiotemporal association between dominant frequency (DF) and re-entrant phase activation areas. METHODS: Eight persAF patients undergoing first-time catheter ablation procedure were enrolled. A non-contact array catheter was deployed into the left atrium (LA) and 2048 AF electrograms (AEG) were acquired for 15 seconds following ventricular far-field cancellation...
April 21, 2017: Heart Rhythm: the Official Journal of the Heart Rhythm Society
https://www.readbyqxmd.com/read/28438721/clinical-profile-and-mutation-spectrum-of-long-qt-syndrome-in-saudi-arabia-the-impact-of-consanguinity
#3
Zuhair N Al-Hassnan, Majid Al-Fayyadh, Bander Al-Ghamdi, Azam Shafquat, Yaseen Mallawi, Faten Al-Hadeq, Sahar Tulbah, Zarghuna Ma Shinwari, Abdulrahman Almesned, Ali Alakhfash, Fadel Al Fadly, Ahmed S Hersi, Abdullah Alhayani, Amal Al-Hashem, Dia Arafah, Nduna Dzimiri, Brian Meyer, Monther Rababh, Waleed Al-Manea
BACKGROUND: Congenital long QT syndrome (LQTS) is an inherited potentially fatal arrhythmogenic disorder. At least 16 genes have been implicated in LQTS; the yield of genetic analysis of 3 genes (KCNQ1, KCNH2, and SCN5A) is about 70% with KCNQ1 mutations accounting for ∼50% of positive cases. LQTS is mostly inherited in an autosomal dominant pattern. Systemic analysis of LQTS has not been previously conducted in a population with a high degree of consanguinity. OBJECTIVES: We aim to describe the clinical and molecular profiles of LQTS in the highly consanguineous Saudi population...
April 21, 2017: Heart Rhythm: the Official Journal of the Heart Rhythm Society
https://www.readbyqxmd.com/read/28438720/sympathetic-neural-recording-it-is-all-in-the-details
#4
EDITORIAL
Jeffrey L Ardell, Kalyanam Shivkumar
No abstract text is available yet for this article.
April 21, 2017: Heart Rhythm: the Official Journal of the Heart Rhythm Society
https://www.readbyqxmd.com/read/28433813/new-tools-to-make-a-percutaneous-epicardial-access-safer-is-the-real-time-pressure-frequency-monitoring-on-the-needle-tip-the-best-way
#5
EDITORIAL
Mauricio I Scanavacca
No abstract text is available yet for this article.
April 19, 2017: Heart Rhythm: the Official Journal of the Heart Rhythm Society
https://www.readbyqxmd.com/read/28416468/cardiac-transplantation-in-children-and-adolescents-with-long-qt-syndrome
#6
Angela M Kelle, J Martijn Bos, Susan P Etheridge, Bryan C Cannon, Randall M Bryant, Jonathan N Johnson, Michael J Ackerman
BACKGROUND: Long QT syndrome (LQTS) is a potentially lethal, yet highly treatable, cardiac channelopathy. Cardiac transplantation has been reported anecdotally for patients with severe LQTS refractory to standard therapies. OBJECTIVE: We evaluated the incidence and risk factors for cardiac transplantation among children evaluated and treated in an LQTS specialty center. METHODS: This was a retrospective review of 349 children with LQTS (mean age at diagnosis, 8...
April 14, 2017: Heart Rhythm: the Official Journal of the Heart Rhythm Society
https://www.readbyqxmd.com/read/28416467/early-repolarization-is-associated-with-significantly-increased-risk-for-ventricular-arrhythmias-and-sudden-cardiac-death-in-patients-with-structural-heart-diseases
#7
Yun-Jiu Cheng, Zhu-Yu Li, Feng-Juan Yao, Xiong-Jun Xu, Cheng-Cheng Ji, Xu-Miao Chen, Li-Juan Liu, Xiao-Xiong Lin, Hao Yao, Su-Hua Wu
BACKGROUND: Early repolarization pattern (ERP) has been proved to increase risk of arrhythmia death in the general population, but its prognostic significance in subjects with structural heart disease (SHD) is controversial. OBJECTIVE: To conduct a meta-analysis of studies assessing the association between ERP and risk of ventricular arrhythmias (VTAs) and sudden cardiac death (SCD) in patients with SHD. METHODS: We performed a literature search using MEDLINE (January 1, 1966 to September25, 2016) and EMBASE (January 1, 1980 to September25, 2016) with no restrictions...
April 14, 2017: Heart Rhythm: the Official Journal of the Heart Rhythm Society
https://www.readbyqxmd.com/read/28416466/risk-of-atrioesophageal-fistula-formation-with-contact-force-sensing-catheters
#8
Eric Black-Maier, Sean D Pokorney, Adam S Barnett, Emily P Zeitler, Albert Y Sun, Kevin P Jackson, Tristram D Bahnson, James P Daubert, Jonathan P Piccini
BACKGROUND: Atrioesophageal fistula formation is a rare but life-threatening complication of AF ablation. Contact force (CF) sensing catheters improve procedural effectiveness. However, the impact of the implementation of CF-sensing technology on risk of atrioesophageal fistula formation has not been explored. OBJECTIVE: To determine the association between the use of CF sensing catheters and atrioesophageal fistula development METHODS: We searched the Manufacturer and User Facility Device Experience (MAUDE) database for adverse event reports involving FDA approved ablation catheters...
April 14, 2017: Heart Rhythm: the Official Journal of the Heart Rhythm Society
https://www.readbyqxmd.com/read/28412158/lidocaine-attenuation-testing-an-in-vivo-investigation-of-putative-lqt3-associated-variants-in-the-scn5a-encoded-sodium-channel
#9
M D Heather N Anderson, J Martijn Bos, Jamie D Kapplinger, Jana M Meskill, Dan Ye, Michael J Ackerman
BACKGROUND: Long QT type 3 (LQT3) accounts for 5-10% of LQTS and results from gain-of-function mutations in the SCN5A-encoded sodium channel. Nearly 2% of healthy individuals host rare SCN5A variants of uncertain significance (VUS). Distinction of true LQT3-causative mutations from background genetic noise is essential. OBJECTIVE: This study was designed to assess the utility of the lidocaine attenuation test (LAT) in evaluating patients with possible LQT3. METHODS: We reviewed LAT results and medical records for 25 patients with a possible LQT3-associated SCN5A variant...
April 12, 2017: Heart Rhythm: the Official Journal of the Heart Rhythm Society
https://www.readbyqxmd.com/read/28412157/are-we-ready-for-a-tissue-identity-card-of-inherited-cardiomyopathies
#10
EDITORIAL
Cristina Basso, Gaetano Thiene
No abstract text is available yet for this article.
April 12, 2017: Heart Rhythm: the Official Journal of the Heart Rhythm Society
https://www.readbyqxmd.com/read/28411139/the-quidam-study-hydroquinidine-therapy-in-the-management-of-brugada-syndrome-patients-at-high-arrhythmic-risk
#11
Antoine Andorin, Jean-Baptiste Gourraud, Jacques Mansourati, Swanny Fouchard, Hervé le Marec, Philippe Maury, Philippe Mabo, Jean-Sylvain Hermida, Jean-Claude Deharo, Beatrice Delasalle, Simon Esnault, Nicolas Sadoul, Jean-Marc Davy, Antoine Leenhardt, Didier Klug, Pascal Defaye, Dominique Babuty, Frédéric Sacher, Vincent Probst
BACKGROUND: Although the implantable cardiac defibrillator (ICD) remains the main therapy in Brugada syndrome (BrS), it does not reduce life-threatening ventricular arrhythmia. Based on pathophysiological mechanisms, hydroquinidine (HQ) has been suggested for the effective prevention of arrhythmia. OBJECTIVE: To provide evidence-based data supporting HQ use to prevent life threatening ventricular arrhythmia in high-risk patients with BrS. METHODS: We performed a prospective multicentre randomised (HQ vs...
April 11, 2017: Heart Rhythm: the Official Journal of the Heart Rhythm Society
https://www.readbyqxmd.com/read/28408329/highest-dominant-frequency-and-rotor-positions-are-robust-markers-of-driver-location-during-non-invasive-mapping-of-atrial-fibrillation-a-computational-study
#12
Miguel Rodrigo, Andreu M Climent, Alejandro Liberos, Francisco Fernández-Avilés, Omer Berenfeld, Felipe Atienza, Maria S Guillem
BACKGROUND: Dominant Frequency (DF) and rotor mapping have been proposed as non-invasive techniques to guide localization of drivers maintaining atrial fibrillation (AF). OBJECTIVE: To evaluate the robustness of both techniques in identifying atrial drivers non-invasively under the effect of electrical noise or model uncertainties. METHODS: Inverse-computed DFs and phase maps were obtained on 30 different mathematical AF simulations. Epicardial Highest DF (HDF) regions and rotor location were compared with the same inverse-computed measurements after addition of noise to the ECG, size variations of the atria and linear or angular deviations in the atrial location inside the thorax...
April 10, 2017: Heart Rhythm: the Official Journal of the Heart Rhythm Society
https://www.readbyqxmd.com/read/28400316/glucose-ingestion-causes-cardiac-repolarization-disturbances-in-type-1-long-qt-syndrome-patients-and-healthy-subjects
#13
Louise Hyltén-Cavallius, Eva W Iepsen, Michael Christiansen, Claus Graff, Allan Linneberg, Oluf Pedersen, Jens J Holst, Torben Hansen, Signe S Torekov, Jørgen K Kanters
BACKGROUND: Both hypo- and severe hyperglycaemia constitute known risk factors for cardiac repolarization changes potentially leading to malignant arrhythmias. Patients with loss of function mutations in KCNQ1 are characterized by long QT-syndrome (LQTS) and may be at increased risk of glucose-induced repolarization disturbances. OBJECTIVE: We hypothezised that KCNQ1 LQTS patients are at particular risk of cardiac repolarization changes during the relative hyperglycaemia that occurs after an oral glucose load...
April 8, 2017: Heart Rhythm: the Official Journal of the Heart Rhythm Society
https://www.readbyqxmd.com/read/28400315/permanent-his-bundle-pacing-for-cardiac-resychronization-therapy-initial-feasibility-study-in-lieu-of-left-ventricular-lead
#14
Olujimi A Ajijola, Gaurav Upadhyay, Carlos Macias, Kalyanam Shivkumar, Roderick Tung
BACKGROUND: Permanent His bundle pacing (HBP) has the potential to physiologically normalize wide QRS duration in patients with bundle branch block and cardiomyopathy. OBJECTIVE: To assess the feasibility of incorporating a His bundle lead for cardiac resychronization therapy (CRT) in lieu of a coronary sinus lead. METHODS: Patients with an indication for CRT (n=21) underwent attempted implantation of a HBP placed into the left ventricular (LV) lead port...
April 8, 2017: Heart Rhythm: the Official Journal of the Heart Rhythm Society
https://www.readbyqxmd.com/read/28396172/role-of-suppression-of-the-inward-rectifier-current-ik1-on-terminal-action-potential-repolarization-in-the-failing-heart
#15
Michael G Klein, Matie Shou, Jayna Stohlman, Soroosh Sohljoo, Myles Haigney, Richard R Tidwell, Robert E Goldstein, Thomas P Flagg, Mark C Haigney
BACKGROUND: The failing heart exhibits an increased arrhythmia susceptibility that is often attributed to action potential (AP) prolongation due to significant ion channel remodeling. IK1 has been reported to be reduced, but its contribution to shaping the AP waveform and cell excitability in the failing heart remains unclear. OBJECTIVE: To define the effect of IK1 suppression on the cardiac AP and excitability in the normal and failing heart. METHODS: We used electrophysiological and pharmacological approaches to investigate IK1 function in a swine tachy-pacing model of heart failure...
April 7, 2017: Heart Rhythm: the Official Journal of the Heart Rhythm Society
https://www.readbyqxmd.com/read/28389305/to-the-editors-risk-factors-for-complications-in-the-implantation-of-epicardial-pacemakers-in-neonates-and-infants
#16
LETTER
Adam C Kean, Mark Rodefeld
No abstract text is available yet for this article.
April 5, 2017: Heart Rhythm: the Official Journal of the Heart Rhythm Society
https://www.readbyqxmd.com/read/28389306/author-s-reply-to-the-editors-risk-factors-for-complications-in-the-implantation-of-epicardial-pacemakers-in-neonates-and-infants
#17
LETTER
A Sami Chaouki, Richard J Czosek
No abstract text is available yet for this article.
April 4, 2017: Heart Rhythm: the Official Journal of the Heart Rhythm Society
https://www.readbyqxmd.com/read/28385673/advancements-in-the-use-of-gene-therapy-for-cardiac-arrhythmia
#18
EDITORIAL
Nathaniel P Murphy, Ellen R Lubbers, Peter J Mohler
No abstract text is available yet for this article.
April 3, 2017: Heart Rhythm: the Official Journal of the Heart Rhythm Society
https://www.readbyqxmd.com/read/28385672/characterization-of-health-care-utilization-in-patients-receiving-implantable-cardioverter-defibrillator-therapies-an-analysis-of-the-managed-ventricular-pacing-trial
#19
John Rickard, David Whellen, Lou Sherfesee, Brett J Peterson, Tara Nahey, Anthony S Tang, Kenneth A Ellenbogen, Alan Cheng
BACKGROUND: Implantable cardioverter defibrillators (ICDs) are effective in terminating lethal arrhythmias, but little is known about the degree of healthcare utilization (HCU) after ICD therapies. OBJECTIVE: Utilizing data from the Managed Ventricular Pacing (MVP) trial, we sought to identify the incidence and types of HCU in ICD recipients after receiving ICD therapy (shocks or anti-tachycardia pacing (ATP)). METHODS: We analyzed HCU events (ventricular tachyarrhythmia (VTA)-related, heart failure (HF)-related, ICD implant procedure-related, ICD system-related, or other) and their association with ICD therapies (shocked ventricular tachycardia (VT) episode, ATP terminated VT episode, inappropriately shocked episode)...
April 3, 2017: Heart Rhythm: the Official Journal of the Heart Rhythm Society
https://www.readbyqxmd.com/read/28385671/the-safety-and-utility-of-magnetic-resonance-imaging-on-patients-with-cardiovascular-implantable-electronic-devices
#20
Jordan B Strom, Jill B Whelan, Changyu Shen, ShuangQi Zheng, Koenraad J Mortele, Daniel B Kramer
BACKGROUND: Off-label magnetic resonance imaging (MRI) for patients with cardiac implantable electrical devices (CIEDs) has been limited due to concerns about safety and unclear diagnostic and prognostic utility. OBJECTIVE: To define major and minor adverse events with off-label MRIs. METHODS: We prospectively evaluated patients with non-MRI-conditional CIEDs referred for MRIs under a strict clinical protocol. The primary safety outcome was incidence of major adverse events (loss of pacing, inappropriate shock or anti-tachycardia pacing, need for system revision, or death), or minor adverse events (inappropriate pacing, arrhythmias, power on reset events, heating at the generator site, or changes in device parameters at baseline or at 6 months)...
March 31, 2017: Heart Rhythm: the Official Journal of the Heart Rhythm Society
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