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Heart Rhythm: the Official Journal of the Heart Rhythm Society

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https://www.readbyqxmd.com/read/28336343/viral-delivered-gene-therapy-to-treat-catecholamine-dependent-polymorphic-ventricular-tachycardia-cpvt2-in-mouse-models
#1
Efrat Kurtzwald-Josefson, Dor Yadin, Shiraz Harun-Khun, Maayan Waldman, Dan Aravot, Asher Shainberg, Michael Eldar, Edith Hochhauser, Michael Arad
BACKGROUND: The recessive form of catecholaminergic polymorphic ventricular tachycardia (CPVT2) is caused by mutations in cardiac calsequestrin (CASQ2), leading to protein defficiency. OBJECTIVE: To develop a viral-delivered gene therapy for CPVT2 and determine the relationship between CASQ2 expression and the antiarrhythmic efficacy in a murine model. METHODS: We used a murine model of CPVT2 caused by the D307H human mutation (CASQ2(D307H)) or CASQ2 knock-out (CASQ2(Δ/Δ))...
March 20, 2017: Heart Rhythm: the Official Journal of the Heart Rhythm Society
https://www.readbyqxmd.com/read/28323174/multicenter-investigation-of-an-implantable-cardioverter-defibrillator-algorithm-to-detect-oversensing
#2
Nicolas Welte, Marc Strik, Romain Eschalier, Pierre Mondoly, Pascal Defaye, Antonio Frontera, Philippe Ritter, Michel Haïssaguerre, Sylvain Ploux, Jayanthi Koneru, Kenneth A Ellenbogen, Pierre Bordachar
BACKGROUND: The SecureSense™ RV Lead Noise Discrimination algorithm is designed to detect lead fracture and other types of oversensing in order to decrease inappropriate therapy. OBJECTIVE: We studied the real-life accuracy of the SecureSenseTM algorithm in ICD patients followed by remote-monitoring across multiple centers. METHODS: Across three French centers, we studied 486 patients with a St. Jude Medical device who were followed by remote-monitoring and who had the SecureSense™ algorithm activated...
March 18, 2017: Heart Rhythm: the Official Journal of the Heart Rhythm Society
https://www.readbyqxmd.com/read/28323173/outcomes-of-cardiac-resynchronization-therapy-in-patients-with-intermittent-atrial-fibrillation-or-atrial-flutter-in-the-companion-trial
#3
Matthew M Kalscheur, Leslie A Saxon, Byron K Lee, Jonathan S Steinberg, Chaoqun Mei, Kevin A Buhr, David L DeMets, Michael R Bristow, Steven N Singh
BACKGROUND: Controlled clinical trial data are lacking for cardiac resynchronization therapy (CRT) outcomes in patients with advanced heart failure (HF) from reduced left ventricular ejection fraction (HFrEF) and intermittent atrial fibrillation or flutter (AF/AFL). OBJECTIVE: To describe CRT outcomes in patients with intermittent AF/AFL and advanced HF. METHODS: HF outcomes in patients from the COMPANION trial with NYHA Class III or IV HFrEF, LVEF ≤ 0...
March 17, 2017: Heart Rhythm: the Official Journal of the Heart Rhythm Society
https://www.readbyqxmd.com/read/28323172/can-long-qt-syndrome-be-diagnosed-by-vectorcardiography-when-the-qtc-on-the-resting-12-lead-ecg-is-of-normal-duration
#4
EDITORIAL
Arthur J Moss
No abstract text is available yet for this article.
March 16, 2017: Heart Rhythm: the Official Journal of the Heart Rhythm Society
https://www.readbyqxmd.com/read/28323171/acquired-long-qt-syndrome-in-hospitalized-patients
#5
Haixu Yu, Li Zhang, Jinqiu Liu, Ying Liu, Peter R Kowey, Yanli Zhang, Yue Chen, Yushan Wei, Lianjun Gao, Huihua Li, Jie Du, Yunlong Xia
BACKGROUND: Acquired long QT syndrome (ALQTS) has long been overlooked in clinical practice. Recent studies reported that severe ALQTS (QTc ≥500 ms) in hospitalized patients is associated with increased all-cause mortality. OBJECTIVE: We aimed to determine the role of ALQTS in the clinical outcomes of hospitalized patients. METHODS: Electronic medical records were reviewed to identify severe ALQTS in hospitalized patients in a single study center from 9-1-2013 to 2-28-2014...
March 16, 2017: Heart Rhythm: the Official Journal of the Heart Rhythm Society
https://www.readbyqxmd.com/read/28323170/localized-atrial-reentrant-tachycardia-in-tetralogy-of-fallot-ultra-high-resolution-mapping-and-termination-by-non-propagated-atrial-pacing-stimulus
#6
Adam Lee, Joel Kite, Oscar Davison, Haris M Haqqani
No abstract text is available yet for this article.
March 16, 2017: Heart Rhythm: the Official Journal of the Heart Rhythm Society
https://www.readbyqxmd.com/read/28315744/cardiac-implantable-electronic-device-infections-who-is-at-greatest-risk
#7
Parijat Saurav Joy, Gagan Kumar, Jeanne E Poole, Barry London, Brian Olshansky
BACKGROUND: Cardiac Implantable Electronic Device (CIED) infections are associated with hospitalization, mortality, increased costs and adverse outcomes. OBJECTIVE: Determine the burden of infections for CIEDs based on device type, associated comorbidities and clinical characteristics over a 12-year period. METHODS: Utilizing the National Inpatient Sample database from 2000-2012, procedures for device related infection (DRI) were identified using ICD-9-CM code for CIED removal with diagnosis codes for device-related infection or systemic infection...
March 15, 2017: Heart Rhythm: the Official Journal of the Heart Rhythm Society
https://www.readbyqxmd.com/read/28315404/obesity-atrial-fibrillation-outcomes-and-risk-increasing-the-weight-of-evidence
#8
EDITORIAL
Chrishan J Nalliah, Prashanthan Sanders, Jonathan M Kalman
No abstract text is available yet for this article.
March 14, 2017: Heart Rhythm: the Official Journal of the Heart Rhythm Society
https://www.readbyqxmd.com/read/28286247/2017-acc-aha-hrs-guideline-for-the-evaluation-and-management-of-patients-with-syncope-a-report-of-the-american-college-of-cardiology-american-heart-association-task-force-on-clinical-practice-guidelines-and-the-heart-rhythm-society
#9
Win-Kuang Shen, Robert S Sheldon, David G Benditt, Mitchell I Cohen, Daniel E Forman, Zachary D Goldberger, Blair P Grubb, Mohamed H Hamdan, Andrew D Krahn, Mark S Link, Brian Olshansky, Satish R Raj, Roopinder Kaur Sandhu, Dan Sorajja, Benjamin C Sun, Clyde W Yancy
No abstract text is available yet for this article.
March 9, 2017: Heart Rhythm: the Official Journal of the Heart Rhythm Society
https://www.readbyqxmd.com/read/28286246/2017-acc-aha-hrs-guideline-for-the-evaluation-and-management-of-patients-with-syncope-executive-summary-a-report-of-the-american-college-of-cardiology-american-heart-association-task-force-on-clinical-practice-guidelines-and-the-heart-rhythm-society
#10
Win-Kuang Shen, Robert S Sheldon, David G Benditt, Mitchell I Cohen, Daniel E Forman, Zachary D Goldberger, Blair P Grubb, Mohamed H Hamdan, Andrew D Krahn, Mark S Link, Brian Olshansky, Satish R Raj, Roopinder Kaur Sandhu, Dan Sorajja, Benjamin C Sun, Clyde W Yancy
No abstract text is available yet for this article.
March 9, 2017: Heart Rhythm: the Official Journal of the Heart Rhythm Society
https://www.readbyqxmd.com/read/28286245/pacing-as-a-treatment-for-reflex-mediated-vasovagal-situational-or-carotid-sinus-hypersensitivity-syncope-a-systematic-review-for-the-2017-acc-aha-hrs-guideline-for-the-evaluation-and-management-of-patients-with-syncope-a-report-of-the-american-college-of-cardiology
#11
Paul D Varosy, Lin Y Chen, Amy L Miller, Peter A Noseworthy, David J Slotwiner, Venkatesh Thiruganasambandamoorthy
OBJECTIVE: To determine, using systematic review of the biomedical literature, whether pacing reduces risk of recurrent syncope and relevant clinical outcomes among adult patients with reflex-mediated syncope. METHODS: MEDLINE (through PubMed), EMBASE, and the Cochrane Central Register of Controlled Trials (through October 7, 2015) were searched for randomized trials and observational studies examining pacing and syncope, and the bibliographies of known systematic reviews were also examined...
March 9, 2017: Heart Rhythm: the Official Journal of the Heart Rhythm Society
https://www.readbyqxmd.com/read/28286244/cardiac-autonomic-neuromodulation-can-kilohertz-frequency-reduce-arrhythmia-frequency
#12
EDITORIAL
Babak Nazer, Edward P Gerstenfeld
No abstract text is available yet for this article.
March 9, 2017: Heart Rhythm: the Official Journal of the Heart Rhythm Society
https://www.readbyqxmd.com/read/28279745/novel-algorithm-for-accelerated-electroanatomical-mapping-and-prediction-of-earliest-activation-of-focal-cardiac-arrhythmias-using-mathematical-optimization
#13
Tobias Weber, Hugo A Katus, Sebastian Sager, Eberhard P Scholz
BACKGROUND: Premature beats (PBs) are a common finding in patients suffering from structural heart disease, but they can also be present in healthy individuals. Catheter ablation represents a suitable therapeutic approach. However, the exact localization of the origin can be challenging, especially in cases of low PB burden during the procedure. OBJECTIVE: Based on the hypothesis that mathematical optimization would significantly accelerate the localization of earliest activation we developed an automated mapping algorithm...
March 6, 2017: Heart Rhythm: the Official Journal of the Heart Rhythm Society
https://www.readbyqxmd.com/read/28279744/advanced-directives-in-icd-patients-some-progress-but-a-long-way-to-go
#14
EDITORIAL
Rachel Lampert
No abstract text is available yet for this article.
March 6, 2017: Heart Rhythm: the Official Journal of the Heart Rhythm Society
https://www.readbyqxmd.com/read/28279743/vectrocardiography-identifies-patients-with-electrocardiographically-concealed-long-qt-syndrome-eclqts
#15
Daniel Cortez, J Martijn Bos, Michael J Ackerman
BACKGROUND: Long QT syndrome (LQTS) and genotypic subtypes are associated with distinctive T wave patterns, arrhythmogenic triggers, and corrected QT interval (QTc) risk associations. Twenty percent of patients with LQTS have normal QTc values, electrographically concealed LQTS (ecLQTS). Vectorcardiography (VCG) has value for sudden cardiac death risk assessment. OBJECTIVE: To determine the utility of VCG to identify patients with ecLQTS. METHODS: We performed a retrospective review on patients with ecLQTS, defined as resting QTc values < 440 ms...
March 6, 2017: Heart Rhythm: the Official Journal of the Heart Rhythm Society
https://www.readbyqxmd.com/read/28274895/transmurality-catch-me-if-you-can
#16
EDITORIAL
Gopi Dandamudi
No abstract text is available yet for this article.
March 5, 2017: Heart Rhythm: the Official Journal of the Heart Rhythm Society
https://www.readbyqxmd.com/read/28267588/initial-international-multicenter-human-experience-with-a-novel-epicardial-access-needle-embedded-with-a-real-time-pressure-frequency-monitoring-to-facilitate-epicardial-access-feasibility-and-safety
#17
Luigi Di Biase, J David Burkhardt, Vivek Reddy, Jorge Romero, Petr Neuzil, Jan Petru, Lucie Sadiva, Jan Skoda, Miguel Ventura, Corrado Carbucicchio, Antonio Dello Russo, Zoltan Csanadi, Michela Casella, Gaetano M Fassini, Claudio Tondo, Frederic Sacher, Mike Theran, Srinivas Dukkipati, Jacob Koruth, Pierre Jais, Andrea Natale
BACKGROUD: Epicardial ablation is often necessary for the treatment of complex arrhythmias refractory to endocardial ablation. Conventional needle access into the pericardial space is considered quite challenging, and it is often associated with several potential complications particularly inadvertent right ventricular puncture. The novel EpiAccess Needle tip is embedded with a pressure sensor able to report the pressure waveform in real time when used with the EpiAccess System. OBJECTIVE: We evaluated the feasibility and safety of the EpiAccess®System by EpiEP, Inc...
March 3, 2017: Heart Rhythm: the Official Journal of the Heart Rhythm Society
https://www.readbyqxmd.com/read/28263909/natural-history-of-arrhythmogenic-cardiomyopathy-redefining-the-age-range-of-clinical-presentation
#18
EDITORIAL
Domenico Corrado, Alessandro Zorzi
No abstract text is available yet for this article.
March 2, 2017: Heart Rhythm: the Official Journal of the Heart Rhythm Society
https://www.readbyqxmd.com/read/28263908/reducing-radiation-exposure-in-the-electrophysiology-lab-a-work-in-progress
#19
EDITORIAL
Carola Gianni, Andrea Natale
No abstract text is available yet for this article.
March 2, 2017: Heart Rhythm: the Official Journal of the Heart Rhythm Society
https://www.readbyqxmd.com/read/28259696/comparison-of-strategies-for-catheter-ablation-of-focal-atrial-tachycardia-originating-near-the-his-bundle-region
#20
Evgeny Lyan, Mauro Toniolo, Alexey Tsyganov, Luca Rebellato, Alessandro Proclemer, Massimiliano Manfrin, Anatoly Nechepurenko, Alexandr Morozov, Ayan Abdrahmanov, Grigory Gromyko, Vitaly Lyashenko, Marina Yakovleva
BACKGROUND: Recent studies have suggested that para-Hisian atrial tachycardia (AT) can be successfully ablated from the right atrium (RA), left atrium (LA) or non-coronary cusp (NCC) in the aorta; however, the best approach remains unclear. OBJECTIVE: This study aimed to compare different approaches to radiofrequency catheter ablation (RFCA) of para-Hisian AT. METHODS: We retrospectively analyzed 68 consecutive patients (72% females, aged 61±13 years) treated with RFCA for this type of AT...
March 1, 2017: Heart Rhythm: the Official Journal of the Heart Rhythm Society
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