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Heart Rhythm: the Official Journal of the Heart Rhythm Society

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https://www.readbyqxmd.com/read/30217527/beyond-the-exercise-stress-test-does-the-cardiac-ryanodine-receptor-affect-intellectual-function
#1
EDITORIAL
Thomas M Roston, Shubhayan Sanatani
No abstract text is available yet for this article.
September 11, 2018: Heart Rhythm: the Official Journal of the Heart Rhythm Society
https://www.readbyqxmd.com/read/30217526/the-anatomy-of-para-hisian-arrhythmias
#2
LETTER
Robert H Anderson, Shumpei Mori
No abstract text is available yet for this article.
September 11, 2018: Heart Rhythm: the Official Journal of the Heart Rhythm Society
https://www.readbyqxmd.com/read/30217525/gender-difference-in-brugada-syndrome-mirror-images-of-long-qt-syndrome
#3
EDITORIAL
Hiroshi Morita
No abstract text is available yet for this article.
September 11, 2018: Heart Rhythm: the Official Journal of the Heart Rhythm Society
https://www.readbyqxmd.com/read/30193854/arrhythmogenic-cardiac-alternans-in-heart-failure-is-suppressed-by-late-sodium-current-blockade-by-ranolazine
#4
Hidehira Fukaya, Bradley N Plummer, Joseph S Piktel, Xiaoping Wan, David S Rosenbaum, Kenneth R Laurita, Lance D Wilson
BACKGROUND: Cardiac alternans is promoted by heart failure (HF) -induced calcium (Ca2+ ) cycling abnormalities. Late sodium current (INa,L ) is enhanced in HF and promotes Ca2+ overload, however, mechanisms underlying an antiarrhythmic effect of INa,L blockade in HF remain unclear. OBJECTIVE: We determined if ranolazine suppresses cardiac alternans in HF by normalizing Ca2+ cycling. METHODS: Transmural dual optical mapping of Ca2+ transients and action potentials was performed in wedge preparations from 8 HF and 8 control (Normal) dogs...
September 4, 2018: Heart Rhythm: the Official Journal of the Heart Rhythm Society
https://www.readbyqxmd.com/read/30193853/time-interval-from-left-ventricular-stimulation-to-qrs-onset-is-a-novel-predictor-of-non-response-to-cardiac-resynchronization-therapy
#5
Daigo Yagishita, Morio Shoda, Yoshimi Yagishita, Koichiro Ejima, Nobuhisa Hagiwara
BACKGROUND: A left ventricular (LV) lead placement at the late activation site (LAS) has been proposed as an optimal LV pacing site (i.e. Q-LV interval). However, LAS may be relevant to local electrical conduction, measured as an interval from LV pacing stimulation to QRS onset (S-QRS interval). OBJECTIVES: This study sought to evaluate the prognostic value of S-QRS for reverse remodeling, and the impact of S-QRS on pacing QRS configuration in patients undergoing cardiac resynchronization therapy (CRT)...
September 4, 2018: Heart Rhythm: the Official Journal of the Heart Rhythm Society
https://www.readbyqxmd.com/read/30193852/unexpected-shift-in-circadian-and-septadian-variation-of-sudden-cardiac-arrest-the-oregon-sudden-unexpected-death-study
#6
Yu-Ming Ni, Carmen Rusinaru, Kyndaron Reinier, Audrey Uy-Evanado, Harpriya Chugh, Eric C Stecker, Jonathan Jui, Sumeet S Chugh
BACKGROUND: Earlier studies have reported both early morning and Monday peaks in occurrence of sudden cardiac arrest (SCA) in the community, and appropriate defibrillator shocks in patients with implantable cardioverter defibrillators (ICD). However, a more recent analysis of ICD shocks reported absence of these peaks. OBJECTIVE: To perform a contemporary evaluation of the circadian and septadian variation of SCA in the general population. METHODS: The analysis was performed from an ongoing, population-based study of SCA in a Northwestern US community of approximately one million residents...
September 4, 2018: Heart Rhythm: the Official Journal of the Heart Rhythm Society
https://www.readbyqxmd.com/read/30193851/clinical-presentation-and-follow-up-of-women-affected-by-brugada-syndrome
#7
Pauline Berthome, Romain Tixier, Jean Briand, Olivier Geoffroy, Dominique Babuty, Jacques Mansourati, Laurence Jesel, Jean-Marc Dupuis, Paul Bru, Florence Kyndt, Béatrice Guyomarch, Aurélie Thollet, Nathalie Behar, Philippe Mabo, Frédéric Sacher, Vincent Probst, Jean-Baptiste Gourraud
BACKGROUND: Studies in Brugada syndrome (BrS) have mainly consisted of men. OBJECTIVES: The aim of this study was to describe the clinical characteristics and arrhythmic risk factors in BrS women. METHODS: Consecutive BrS patients were enrolled from 1993 and followed prospectively. RESULTS: Among 1613 patients, 494 were women (mean age 47±16 years). Women were more frequently asymptomatic than men (respectively n=423(86%) vs...
September 4, 2018: Heart Rhythm: the Official Journal of the Heart Rhythm Society
https://www.readbyqxmd.com/read/30172028/predictive-value-of-exercise-testing-in-athletes-with-ventricular-ectopy-evaluated-by-cardiac-magnetic-resonance
#8
Alberto Cipriani, Alessandro Zorzi, Patrizio Sarto, Martino Donini, Ilaria Rigato, Riccardo Bariani, Manuel De Lazzari, Kalliopi Pilichou, Gaetano Thiene, Sabino Iliceto, Cristina Basso, Domenico Corrado, Martina Perazzolo Marra, Barbara Bauce
BACKGROUND: Exercise-induced ventricular arrhythmias (EIVAs) in young athletes raise the suspicion of an underlying heart disease at risk of sudden death. OBJECTIVE: We aimed to assess the prevalence and determinants of abnormal cardiac magnetic resonance (CMR) findings in athletes referred for EIVA vs non-EIVA with negative or inconclusive echocardiography. METHODS: We performed CMR in a consecutive series of athletes aged 15-50 years referred for frequent (>500 per day) or repetitive premature ventricular beats...
August 30, 2018: Heart Rhythm: the Official Journal of the Heart Rhythm Society
https://www.readbyqxmd.com/read/30172029/a-pore-localizing-cacna1c-e1115k-missense-mutation-identified-in-a-patient-with-idiopathic-qt-prolongation-bradycardia-and-autism-spectrum-disorder-converts-the-l-type-calcium-channel-into-a-hybrid-nonselective-monovalent-cation-channel
#9
Dan Ye, David J Tester, Wei Zhou, John Papagiannis, Michael J Ackerman
BACKGROUND: Gain-of-function variants in the CACNA1C-encoded L-type calcium channel (LTCC, Cav1.2) cause type 8 long QT syndrome (LQT8). The pore region contains highly conserved glutamic acid (E) residues that collectively form the LTCC's selectivity filter. Here, we identified and characterized a pore-localizing missense variant, E1115K, that yielded a novel perturbation in the LTCC. OBJECTIVE: The purpose of this study was to determine whether CACNA1C-E1115K alters the LTCC's selectivity and is the substrate for the patient's LQTS...
August 29, 2018: Heart Rhythm: the Official Journal of the Heart Rhythm Society
https://www.readbyqxmd.com/read/30172027/extraction-of-transvenous-leads-while-anticoagulated
#10
EDITORIAL
Jay A Montgomery, George H Crossley
No abstract text is available yet for this article.
August 29, 2018: Heart Rhythm: the Official Journal of the Heart Rhythm Society
https://www.readbyqxmd.com/read/30170229/circadian-rhythm-of-cardiac-electrophysiology-arrhythmogenesis-and-the-underlying-mechanisms
#11
Nicholas Black, Alicia D'Souza, Yanwen Wang, Hugh Piggins, Halina Dobrzynski, Gwilym Morris, Mark R Boyett
Cardiac arrhythmias are a leading cause of cardiovascular death. It has long been accepted that life-threatening cardiac arrhythmias (ventricular tachycardia, ventricular fibrillation, and sudden cardiac death) are more likely to occur in the morning after waking. It is perhaps less well recognized that there is a circadian rhythm in cardiac pacemaking and other electrophysiological properties of the heart. In addition, there is a circadian rhythm in other arrhythmias, for example, bradyarrhythmias and supraventricular arrhythmias...
August 29, 2018: Heart Rhythm: the Official Journal of the Heart Rhythm Society
https://www.readbyqxmd.com/read/30170230/a-balanced-translocation-disrupting-scn5a-in-a-family-with-brugada-syndrome-and-sudden-cardiac-death
#12
Laura Yeates, Grad Dip Gen Couns, Jodie Ingles, Belinda Gray, Suresh Singarayar, Raymond W Sy, Christopher Semsarian, Richard D Bagnall
BACKGROUND: Brugada syndrome (BrS) is a primary arrhythmia syndrome affecting 1 in 2000 of the general population. Genetic testing identifies pathogenic variants in the sodium voltage-gated channel α-subunit 5 gene (SCN5A) in up to 25% of familial BrS. Balanced translocations, which involve the exchange of the ends of 2 different chromosomes, are found in approximately 1 in 500 people. They usually are benign and only rarely are reported to cause arrhythmogenic disorders. OBJECTIVE: The purpose of this study was to identify the genetic mechanism underlying a family with BrS, sick sinus syndrome, cardiac hypertrophy, sudden cardiac death, and multiple miscarriages...
August 28, 2018: Heart Rhythm: the Official Journal of the Heart Rhythm Society
https://www.readbyqxmd.com/read/30170228/linking-the-heart-and-the-brain-neurodevelopmental-disorders-in-patients-with-catecholaminergic-polymorphic-ventricular-tachycardia
#13
Krystien V V Lieve, Judith M A Verhagen, Jinhong Wei, J Martijn Bos, Christian van der Werf, Ferran Rosés I Noguer, Grazia M S Mancini, Wenting Guo, Ruiwu Wang, Freek van den Heuvel, Ingrid M E Frohn-Mulder, Wataru Shimizu, Akihiko Nogami, Hitoshi Horigome, Jason D Roberts, Antoine Leenhardt, Harry J G Crijns, Andreas C Blank, Takeshi Aiba, Ans C P Wiesfeld, Nico A Blom, Naokata Sumitomo, Jan Till, Michael J Ackerman, S R Wayne Chen, Ingrid M B H van de Laar, Arthur A M Wilde
BACKGROUND: Catecholaminergic polymorphic ventricular tachycardia (CPVT) is an uncommon inherited arrhythmia disorder characterized by adrenergically evoked ventricular arrhythmias. Mutations in the cardiac calcium release channel/ryanodine receptor gene (RYR2) are identified in the majority of patients with CPVT. RyR2 is also the major RyR isoform expressed in the brain. OBJECTIVE: The purpose of this study was to estimate the prevalence of intellectual disability (ID) and other neurodevelopmental disorders (NDDs) in RYR2-associated CPVT (CPVT1) and to study the characteristics of these patients...
August 28, 2018: Heart Rhythm: the Official Journal of the Heart Rhythm Society
https://www.readbyqxmd.com/read/30170227/vectorcardiographic-qrs-area-is-associated-with-long-term-outcome-after-cardiac-resynchronization-therapy
#14
Kasper Emerek, Daniel J Friedman, Peter Lyngø Sørensen, Steen Møller Hansen, Jacob Moesgaard Larsen, Niels Risum, Anna Margrethe Thøgersen, Claus Graff, Joseph Kisslo, Peter Søgaard, Brett D Atwater
BACKGROUND: Recent studies have suggested that vectorcardiographic measures predict left ventricular (LV) reverse remodeling and clinical outcome in patients receiving cardiac resynchronization therapy (CRT). OBJECTIVES: The objectives of this study were to compare predictive abilities of different vectorcardiographic measures (QRS area and sum absolute QRS-T integral) and transformation methods (Kors and inverse Dowers) and to assess the independent association between the best predictor and outcomes in CRT recipients...
August 28, 2018: Heart Rhythm: the Official Journal of the Heart Rhythm Society
https://www.readbyqxmd.com/read/30170226/are-pediatric-catheter-ablation-outcomes-approaching-a-pareto-frontier
#15
EDITORIAL
Jonathan R Kaltman
No abstract text is available yet for this article.
August 28, 2018: Heart Rhythm: the Official Journal of the Heart Rhythm Society
https://www.readbyqxmd.com/read/30170225/prognostic-efficacy-of-platelet-count-in-patients-with-nonvalvular-atrial-fibrillation
#16
Jiesuck Park, Myung-Jin Cha, You-Jung Choi, Euijae Lee, Inki Moon, Soongu Kwak, Soonil Kwon, Seokhun Yang, Seoyoung Lee, Eue-Keun Choi, Seil Oh
BACKGROUND: The prognostic efficacy of quantitative platelet activity in atrial fibrillation (AF) remains unclear. OBJECTIVE: The purpose of this study was to evaluate the platelet count (PLT) as a prognostic indicator in patients with nonvalvular AF. METHODS: Data on 10,978 patients with nonvalvular AF were retrieved from a prospective registry of a single medical center in Korea. Cumulative risk for stroke and bleeding events were compared between patients with normal PLT (n = 8322), mild thrombocytopenia (n = 1791), and moderate to severe thrombocytopenia (n = 865) after propensity score matching...
August 28, 2018: Heart Rhythm: the Official Journal of the Heart Rhythm Society
https://www.readbyqxmd.com/read/30144582/does-plastic-chemical-exposure-contribute-to-sudden-death-of-patients-on-dialysis
#17
Larisa G Tereshchenko, Nikki G Posnack
No abstract text is available yet for this article.
August 23, 2018: Heart Rhythm: the Official Journal of the Heart Rhythm Society
https://www.readbyqxmd.com/read/30144581/technique-analysis-how-can-we-improve-outcomes
#18
EDITORIAL
Bruce L Wilkoff
No abstract text is available yet for this article.
August 23, 2018: Heart Rhythm: the Official Journal of the Heart Rhythm Society
https://www.readbyqxmd.com/read/30142380/cosmetic-aspects-of-device-implantation
#19
Peter H Belott
No abstract text is available yet for this article.
August 22, 2018: Heart Rhythm: the Official Journal of the Heart Rhythm Society
https://www.readbyqxmd.com/read/30125719/implantation-techniques-and-outcomes-after-cardiac-resynchronization-therapy-for-congenitally-corrected-transposition-of-the-great-arteries
#20
Jeremy P Moore, David Cho, Jeannette P Lin, Gentian Lluri, Leigh C Reardon, Jamil A Aboulhosn, Abbie Hageman, Kevin M Shannon
BACKGROUND: Patients with congenitally corrected transposition of the great arteries (CCTGA) are at risk of congestive heart failure (CHF). There are limited data on cardiac resynchronization therapy (CRT) techniques and long-term outcomes in this population. OBJECTIVE: The purpose of this study was to determine implantation techniques and efficacy of CRT for CCTGA. METHODS: A 15-year retrospective review of patients with CCTGA undergoing CRT was performed...
August 18, 2018: Heart Rhythm: the Official Journal of the Heart Rhythm Society
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