Ioannis Doundoulakis, Luigi Pannone, Sotirios Chiotis, Domenico Giovanni Della Rocca, Antonio Sorgente, Panagiotis Tsioufis, Alvise Del Monte, Giampaolo Vetta, Christos Piperis, Ingrid Overeinder, Gezim Bala, Alexandre Almorad, Erwin Ströker, Juan Sieira, Mark La Meir, Pedro Brugada, Dimitrios Tsiachris, Andrea Sarkozy, Gian Battista Chierchia, Carlo de Asmundis
BACKGROUND: A rare gene variant in SCN5A can be found in approximately 20-25% of patients with Brugada syndrome (BrS). OBJECTIVE: The aim of this systematic review and meta-analysis is to evaluate: (1) differences in clinical characteristics of BrS patients with and without SCN5A rare variants and (2) the prognostic role of SCN5A for ventricular arrhythmias in BrS. METHODS: PubMed and Cochrane Central Register of Controlled Trials (CENTRAL) were systematically searched from inception to January 2024 to identify all relevant studies...
April 11, 2024: Heart Rhythm: the Official Journal of the Heart Rhythm Society