Nasr Y Khalil, Haitham K AlRabiah, Saad S Al Rashoud, Ahmed Bari, Tanveer A Wani
Topiramate, 2,3:4,5-di-O-isopropylidene-β-d-fructopyranose sulfamate, is a potent antiepileptic drug with a broad spectrum of activity. It is effective in both partial and generalized seizures. Topiramate was also found to have significant efficacy in migraine prevention with considerable reductions in the frequency of migraine headaches. The most common adverse events, which may accompany the use of topiramate, are paresthesia, fatigue, decreased appetite, nausea, diarrhea, weight decrease and taste perversion...
2019: Profiles of Drug Substances, Excipients, and related Methodology