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Chemistry & Biodiversity

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https://www.readbyqxmd.com/read/28504841/chemical-composition-antibacterial-schistosomicidal-and-cytotoxic-activities-of-the-essential-oil-of-dysphania-ambrosioides-l-mosyakin-clemants-chenopodiaceae
#1
Marina H Soares, Herbert J Dias, Tatiana M Vieira, Maria G M de Souza, Ana F F Cruz, Fernanda R Badoco, Heloiza D Nicolella, Wilson R Cunha, Milton Groppo, Carlos H G Martins, Denise C Tavares, Lizandra G Magalhães, Antônio E M Crotti
We have investigated the chemical composition and the antibacterial activity of the essential oil of Dysphania ambrosioides (L.) Mosyakin & Clemants (Chenopodiaceae) (DA-EO) against a representative panel of cariogenic bacteria. We have also assessed the in vitro schistosomicidal effects of DA-EO on Schistosoma mansoni and its cytotoxicity to GM07492-A cells in vitro. Gas chromatography (GC) and gas chromatography-mass spectrometry (GC-MS) revealed that the monoterpenes cis-piperitone oxide (35.2%), p-cymene (14...
May 15, 2017: Chemistry & Biodiversity
https://www.readbyqxmd.com/read/28502117/passive-membrane-penetration-of-the-serotonin-precursor-5-hydroxytryptophan-is-controlled-by-its-zwitterion
#2
Károly Mazák, Béla Noszál
Species-specific partition coefficients in the octanol/water system were determined for the neurotransmitter serotonin (5-HT) and its precursor 5-hydroxytryptophan (5-HTP). The pH-independent partition coefficients (p) of the individual microspecies were determined by combination of experimentally measured distribution constants and a custom-tailored evaluation method, using highly similar auxiliary compounds. Experimental microscopic partition coefficients for triprotic molecules have only been reported before for thyroxine and its derivatives...
May 14, 2017: Chemistry & Biodiversity
https://www.readbyqxmd.com/read/28502116/phenolic-composition-anti-inflammatory-antioxidant-and-antimicrobial-activities-of-alchemilla-mollis-buser-rothm
#3
Gökçe Şeker Karatoprak, Selen İlgün, Müberra Koşar
The current study was designed to evaluate the antioxidant, anti-inflammatory and antimicrobial activities of Alchemilla mollis (Buser) Rothm. (Rosaceae) aerial parts extracts. Chemical composition was analyzed by spectrophotometric and chromatographic (HPLC) techniques. The antioxidant properties assessed included, DPPH(●) and ABTS(●+) radical scavenging, β-carotene-linoleic acid co-oxidation assay. Antimicrobial activity was evaluated with disc diffusion and micro dilution method. In order to evaluate toxicity of the extracts with the sulforhodamine B (SRB) colorimetric assay L929 cell line (mouse fibroblast) was used...
May 14, 2017: Chemistry & Biodiversity
https://www.readbyqxmd.com/read/28498611/design-synthesis-and-biological-evaluation-of-peptidomimetic-n-substituted-cbz-4-hyp-hpa-amides-as-novel-inhibitors-of-plasmodium-falciparum
#4
Valeriy A Bacherikov, Amar G Chittiboyina, Mitchell A Avery
A new series of peptidomimetic N-substituted Cbz-4-Hyp-Hpa-amides was designed, synthesized and evaluated for inhibition of the Plasmodium falciparum. Substituents on the N atom of the amide group were selected. They are the following alkyl-, allyl-, aryl-, 2-hydroxyethyl-, 2-cyanoethyl-, cyanomethyl-, 2-hydroxyethyl-, 2,2-diethoxyethyl-, or 2-ethoxy-2-oxoethylamino groups, and about forty new compounds were synthesized and evaluated for anti-plasmodial activity in vitro. Antimalarial activity was investigated as for the final peptide mimetics, and their immediate predecessors, carrying TBDMS or TBDPS protecting groups on 4-hydroxyproline residue and eighteen derivatives exhibited toxicity against P...
May 12, 2017: Chemistry & Biodiversity
https://www.readbyqxmd.com/read/28488417/melanogenesis-inhibitory-and-antioxidant-activities-of-phenolics-from-periploca-forrestii
#5
Cai-Ling Sun, Lei Chen, Jian Xu, Wei Qu, Li Guan, Wen-Yuan Liu, Toshihiro Akihisa, Feng Feng, Jie Zhang
Two new tetrahydrofuran-type lignans, (-)-gentioluteol-9-O-β-D-glucoside (1), (-)-berchemol 9-O-β-D-apiofuranosyl-(1→6)-O-β-D-glucopyranoside (2), along with sixteen known compounds 3-18 were isolated from the 95% EtOH extract of the stems of Periploca forrestii. The structures of new tetrahydrofuran-type lignans were determined by HR-ESI-MS and various NMR techniques in combination with CD method. Then, their antioxidant abilities were evaluated by 1,1-diphenyl-2-picrylhydrazul (DPPH), 2,2'-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS) radical scavenging activity, and ferric-reducing antioxidant power (FRAP) assays...
May 10, 2017: Chemistry & Biodiversity
https://www.readbyqxmd.com/read/28488391/essential-oil-variability-in-natural-populations-of-artemisia-campestris-l-and-artemisia-herba-alba-asso-and-incidence-on-antiacetylcholinesterase-and-antioxidant-activities
#6
Faten Younsi, Sameh Mehdi, Oumayma Aissi, Najoua Rahali, Rym Jaouadi, Mohamed Boussaid, Chokri Messaoud
The intraspecific variability of A. herba-alba and A. campestris essential oils and the evaluation of their antioxidant and antiacetylcholinesterase activities were determined. A. herba-alba essential oil was found rich in camphor (19.61%), α-thujone (19.40%), β-thujone (9.44%), chrysanthenone (9.26%) and trans-sabinyl acetate (8.43%). The major compounds of A. campestris essential oil were germacrene D (16.38%), β-pinene (16.33%) and limonene (9.17%). Significant variation in the essential oil composition was observed among populations of each species...
May 10, 2017: Chemistry & Biodiversity
https://www.readbyqxmd.com/read/28488389/chemical-profiling-and-assessment-of-antineurodegenerative-and-antioxidant-properties-of-veronica-teucrium-l-and-veronica-jacquinii-baumg
#7
Jelena Č Živković, João C M Barreira, Katarina P Šavikin, Ana Z Alimpić, Dejan S Stojković, Maria Inês Dias, Celestino Santos-Buelga, Sonja N Duletić-Laušević, Isabel C F R Ferreira
Neuroprotective potential of V. teucrium and V. jacquinii methanol extracts was analyzed. Chemical analysis of investigated extracts showed the presence of phenolic acid derivatives, flavonoids and one secoiridoid. The detected flavonoids derived from flavones (luteolin and isoscutellarein in V. jacquinii; apigenin, isoscutellarein and luteolin in V. teucrium) and flavonol (quercetin in V. jacquinii). Acteoside was the dominant compound in V. jacquinii, while plantamajoside and isoscutellarein 7-O-(6'''-O-acetyl)-β-allosyl (1'''→2''')-β-glucoside were the major phenolics in V...
May 10, 2017: Chemistry & Biodiversity
https://www.readbyqxmd.com/read/28477421/terpenes-are-useful-markers-in-differentiation-of-natural-populations-of-relict-pines-pinus-heldreichii-p-nigra-and-p-peuce
#8
Zorica S Mitić, Biljana M Nikolić, Mihailo S Ristić, Vele V Tešević, Srdjan R Bojović, Petar D Marin
Comparative analysis of terpene diversity and differentiation of relict pines Pinus heldreichii, P. nigra, and P. peuce from the central Balkans was performed at the population level. Multivariate statistical analyses showed that composition of needle terpenes reflects clear divergence among the pine species from different subgenera: P. peuce (subgenus Strobus) vs. P. nigra and P. heldreichii (subgenus Pinus). In addition, despite the described morphological similarities and the fact that P. nigra and P. heldreichii may spontaneously hybridize, our results indicated differentiation of their populations naturally growing in the same area...
May 6, 2017: Chemistry & Biodiversity
https://www.readbyqxmd.com/read/28477416/systematic-identification-and-competitive-disruption-of-securin-binding-partners-in-the-gene-diversity-space-of-human-colorectal-cancer
#9
Yinguang Zhang, Yongwang Zhang, Yuxiang Zhang
Human securin is regulatory protein involved in control of the metaphase-anaphase transition and anaphase onset of colorectal cancer. Molecular evidences suggest that the protein is integrated into oncogenic signaling network by binding to SH3-containing proteins through its proline-rich peptides. In this study, we have performed a genome-wide analysis and identification of securin-binding partners in the gene diversity space of human colorectal cancer. The securin-binding potency of SH3-containing proteins found in colorectal cancer was investigated by using bioinformatics modeling and intermolecular assay...
May 6, 2017: Chemistry & Biodiversity
https://www.readbyqxmd.com/read/28477412/salvia-officinalis-l-essential-oil-from-spain-determination-of-composition-antioxidant-capacity-antienzymatic-and-antimicrobial-bioactivities
#10
Ana-Belen Cutillas, Alejandro Carrasco, Ramiro Martinez-Gutierrez, Virginia Tomas, José Tudela
Four essential oils (EOs) from Salvia officinalis L. cultivated in Spain (Murcia province) were analyzed by gas chromatography coupled with mass spectrometry (GC/MS) to determine their relative and absolute composition. The main components were α-thujone (22.8-41.7%), camphor (10.7-19.8%), 1,8-cineole (4.7-15.6%) and β-thujone (6.1-15.6%). Enantioselective gas chromatography identified (-)-α-thujone and (+)-camphor as the main enantiomers in all the analyzed EOs. Furthermore, when the EOs were tested to determine their antioxidant activity against free radicals and as ferric reducing and ferrous chelating agents, all were seen to have moderate activity due to the compounds they contained, such as linalool or terpinene...
May 6, 2017: Chemistry & Biodiversity
https://www.readbyqxmd.com/read/28467692/chemical-composition-and-antimicrobial-activity-of-essential-oils-from-the-aerial-parts-of-asteriscus-graveolens-forssk-less-and-pulicaria-incisa-lam-dc-two-asteraceae-herbs-growing-wild-in-the-hoggar
#11
Faiza Chaib, Hocine Allali, Malika Bennaceur, Guido Flamini
In recent years, antimicrobial activities of essential oils have been intensively explored, mainly in researching and developing new antimicrobial agents to overcome microbial resistance. The present study investigates the chemical composition and antimicrobial activities of essential oils obtained from two Asteraceae: Asteriscus graveolens (Forssk.) Less. and Pulicaria incisa (Lam.) DC. Chemical analysis was performed using a combination of capillary GC-FID and GC/MS analytical techniques. The major component of Asteriscus graveolens were cis-chrysanthenyl acetate (31...
May 3, 2017: Chemistry & Biodiversity
https://www.readbyqxmd.com/read/28452174/chemical-characterization-of-lodoicea-maldivica-fruit
#12
Bartolomeo Sebastiani, Martino Giorgini, Stefano Falcinelli
In the present study, we report the attempt to characterize the chemical composition of fruit kernel of "Lodoicea Maldivica" coco nucifera palm (commonly named as "Coco de mer") by gas chromatographic method. The analysis was performed by HS-SPME and GC/MS techniques to determine volatile aroma, sterol and fatty acid composition profiles in the internal and external pulp of two distinct coconuts. Despite no qualitative differences in flavour composition were observed between the two analysed coconuts and the relative two pulp parts, variations in the abundance levels of the prominent compounds have been recorded...
April 27, 2017: Chemistry & Biodiversity
https://www.readbyqxmd.com/read/28452167/new-eudesmane-sesquiterpenoids-from-salvia-plebeia-r-br
#13
Lie-Feng Ma, Peng-Fei Wang, Ji-Dong Wang, Xiang-Min Tong, Wei-Guang Shan, Hui Zhang, Zha-Jun Zhan
Three new sesquiterpenoids salplebeones A-C (1-3), were isolated from the ethanol-soluble extract of the aerial part of Salvia plebeia R. Br. Their structures were established by detailed analysis of NMR and MS spectra. Salplebeone A was an eudesmane lactone, while salplebeones B-C were rare eudesmane sesquiterpenoids, containing 12, 8-lactam groups. Antiproliferative activities of salplebeones A-C to myeloid leukemia cell lines were evaluated. This article is protected by copyright. All rights reserved.
April 27, 2017: Chemistry & Biodiversity
https://www.readbyqxmd.com/read/28444991/new-hydrazides-and-hydrazide-hydrazones-of-2-3-dihalogen-substituted-propionic-acids-synthesis-and-in-vitro-antimicrobial-activity-evaluation
#14
Łukasz Popiołek, Anna Biernasiuk
The main aim of this research was the synthesis, spectral identification and in vitro antimicrobial evaluation of new hydrazides and hydrazide-hydrazones of 2,3-dihalogen substituted propionic acids. New hydrazides were obtained by the substitution reaction of appropriate ethyl esters of 2,3-dihalogen substituted propionic acids with hydrazine hydrate. Then obtained hydrazides were subjected to condensation reaction with various aldehydes which yielded with new hydrazide-hydrazone derivatives. All obtained compounds were identified on the basis of spectral methods ((1) H NMR, (13) C NMR) and in vitro screened against a panel of bacterial and fungal strains according to EUCAST and CLSI guidelines...
April 26, 2017: Chemistry & Biodiversity
https://www.readbyqxmd.com/read/28434194/cytotoxic-triterpenoids-from-the-stalks-of-microtropis-triflora
#15
Xiao-Wei Zhang, Kui-Wu Wang, Man-Qing Zhou
Bioassay-guided phytochemcal investigation of the stalks of Microtropis triflora Merr. et Freem led to the isolation of ten triterpenes 1-10, including one novel compound 24-epoxy-2α, 24-dihydroxy-29-friedelanoic acid (1). Their chemical structures were identified on the basis of spectroscopic analysis, including HRESI mass spectrometry, 1D and 2D NMR ((1) H, (13) C, (1) H-(1) H COSY, HSQC, HMBC and NOESY), and by comparison with the data reported. The cytotoxicities of the compounds 1-10 against a panel of cultured human tumor cell lines (Bcap37, SMMC7721, Hela, CNE) were evaluated...
April 23, 2017: Chemistry & Biodiversity
https://www.readbyqxmd.com/read/28425165/melanogenesis-inhibitory-and-cytotoxic-activities-of-limonoids-alkaloids-and-phenolic-compounds-from-phellodendron-amurense-bark
#16
Toshihiro Akihisa, Satoru Yokokawa, Eri Ogihara, Masahiro Matsumoto, Jie Zhang, Takashi Kikuchi, Kazuo Koike, Masahiko Abe
Four limonoids, 1-4, five alkaloids, 5-9, and four phenolic compounds, 10-13, were isolated from a MeOH extract of the bark of Phellodendron amurense (Rutaceae). Among these, compound 13 was a new, and its structure was established as rel-(1R,2R,3R)-5-hydroxy-3-(4-hydroxy-3-methoxyphenyl)-6-methoxy-1-(methoxycarbonylmethyl)indane-2-carboxylic acid methyl ester (γ-di(methyl ferulate)) based on the spectrometric analysis. Upon evaluation of compounds 1-13 against the melanogenesis in the B16 melanoma cells induced with α-melanocyte-stimulating hormone (α-MSH), four compounds, limonin (1), noroxyhydrastinine (6), haplopine (7), and 4-methoxy-N-methyl-2-quiolone (8), exhibited potent melanogenesis-inhibitory activities with almost no toxicity to the cells...
April 20, 2017: Chemistry & Biodiversity
https://www.readbyqxmd.com/read/28422413/essential-oils-as-biocides-for-the-control-of-fungal-infections-and-devastating-pest-tuta-absoluta-of-tomato-lycopersicon-esculentum-mill
#17
Samira Bouayad Alam, Mohammed El Amine Dib, Nassim Djabou, Boufeldja Tabti, Nassira Guaouar, Jean Costa, Alain Muselli
Thymus capitatus and Tetraclinis articulata essential oils as well their major components (carvacrol and α-pinene) were evaluated for their antifungal and insecticidal activities. Both oils showed good in vitro antifungal activity against Fusarium oxysporum, Aspergillus niger, Penicillium sp, Alternaria alternata and Botrytis cinerea, the fungi causing tomato rot. In vivo results indicate the efficacies of both essential oils and carvacrol of reduce postharvest fungal pathogens, such as B. cinerea and A. alternata that are responsible of black and gray rot of tomato fruit...
April 19, 2017: Chemistry & Biodiversity
https://www.readbyqxmd.com/read/28419767/four-new-diterpene-glucosides-from-perovskia-atriplicifolia
#18
Lu Gao, Jun Zhou, Le-Yu Zhu, Juan-Rong Zhang, Yu-Xing Jing, Jia-Wen Zhao, Xiang-Zhong Huang, Gan-Peng Li, Zhi-Yong Jiang, Da-Yuan Xue
Four new diterpene glucosides, namely perovskiaditerpenosides A-D (1-4), were isolated from the butanol extract of Perovskia atriplicifolia. Their structures were well elucidated by chemical methods and comprehensive spectroscopic analyses including MS, IR, and NMR (1D and 2D). The newly isolated compounds were screened for their cytotoxic activity against HepG2, NB4 Hela, K562, HL60, MCF7 and HL60. The obtained results indicated that the new compounds possessed considerable cytotoxic activity. This article is protected by copyright...
April 17, 2017: Chemistry & Biodiversity
https://www.readbyqxmd.com/read/28398659/hypaphorine-an-indole-alkaloid-isolated-from-caragana-korshinskii-kom-inhibites-3t3-l1-adipocyte-differentiation-and-improves-insulin-sensitivity-in-vitro
#19
Guangxiang Luan, Fangfang Tie, Zhenzhen Yuan, Gang Li, Jie He, Zhenhua Wang, Honglun Wang
Obesity, a major health problem worldwide, is a complex multifactorial chronic disease that increases the risk for insulin resistance, type 2 diabetes, coronary heart disease and hypertension. In this study, we assessed methods to isolate hypaphorine, a potent drug candidate for obesity and insulin resistance. Semi-preparative reversed-phase liquid chromatography (semi-preparative RPLC) was established as a method to separate three compounds, adenosine, L-tryptophan and hypaphorine, from the crude extracts of Caragana korshinskii Kom...
April 11, 2017: Chemistry & Biodiversity
https://www.readbyqxmd.com/read/28398606/variation-in-essential-oil-and-bioactive-compounds-of-curcuma-kwangsiensis-collected-from-natural-habitats
#20
Lanyue Zhang, Zhiwen Yang, Zebin Huang, Mincong Zhao, Penghui Li, Wei Zhou, Kun Zhang, Xi Zheng, Li Lin, Jian Tang, Yanxiong Fang, Zhiyun Du
The chemical compositions of essential oils (EOs) extracted from Curcuma kwangsiensis rhizomes collected from six natural habitats in China were evaluated using gas chromatography-mass spectrometry (GC-MS). Fifty-seven components were identified from the six Eos; their main constituents were 8,9-dehydro-9-formyl-cycloisolongifolene (2.37-42.59%), germacrone (6.53-22.20%), and L-camphor (0.19-6.12%). The six EOs exhibited different DPPH radical-scavenging activities (IC50 , 2.24-31.03 μg/mL), with the activity of most of the EOs being much higher than that of Trolox C (IC50 , 10...
April 11, 2017: Chemistry & Biodiversity
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