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Chemistry & Biodiversity

Jie-Li Lv, Zhou Li, Li-Min Guo, Lai-Bin Zhang
Two new sesquiterpene lactones, artelavanolides A (1) and B (2), and four known sesquiterpene lactones (3-6) were isolated from the leaves of Artemisia lavandulaefolia. Their structures were elucidated based on the analysis of spectroscopic data (1D, 2D NMR and HRESIMS). The absolute configuration of 1 was determined by the analysis of single-crystal X-ray diffraction data. Artelavanolide A (1) is a rare sesquiterpene lactone possessing an unusual skeleton with the linkage of Me(14)-C(1) that is probably formed through a rearrangement of the guaiane-type sesquiterpenoids...
March 15, 2018: Chemistry & Biodiversity
Manuel Minteguiaga, H Andrés González, Eduardo Cassel, Noelia Umpierrez, Laura Fariña, Eduardo Dellacassa
Chemical bioprospecting is an important tool for generating knowledge regarding local human-threatened floras and for conservation management. For Baccharis L. (Asteraceae), several volatile components have been reported for Brazil, Argentina, Bolivia, and Chile as a result of bioprospection, but not for Uruguayan flora, which is composed of more than 50 native species. In this work, through collection of aerial parts of different species and volatile simultaneous-distillation extraction and gas chromatography-mass spectrometry analyses, 12 native species of Baccharis were studied (B...
March 14, 2018: Chemistry & Biodiversity
Dorota Woźniak, Sylwester Ślusarczyk, Krzysztof Domaradzki, Andrzej Dryś, Adam Matkowski
European Pharmacopoeia accepts two equivalent species Solidago canadensis L. and S. gigantea Ait. as Goldenrod (Solidaginis herba). We compared phytochemical profile of both species from invasive populations in Poland. Further, we compared in vitro antimutagenic and antioxidant activities of solvent extracts from aerial (AP) and underground parts (UP). In S. gigantea, flavonoid profile was dominated by quercetin glycosides, with quercitrin as the major compound. In S. canadensis, quercetin and kaempferol rutinosides were two major constituents...
March 14, 2018: Chemistry & Biodiversity
Fatuma Felix Felician, Chunlei Xia, Weiyan Qi, Hanmei Xu
Collagen is the most studied protein with a wide range of applications including pharmaceutical, biomedical, cosmetics, leather and film industries due to its special characteristics that are high biocompatibility, good bioactivity, and weak antigenicity. Although collagen sources are abundant, the outbreak of varied diseases among land animals posed threat to its utilization in our daily life. Thus, a probe for an alternative source began, which in turn revealed the immense untapped marine sources, such as fish, jellyfish, and some marine Mammals...
March 9, 2018: Chemistry & Biodiversity
Benjamin Mutschlechner, Bettina Rainer, Stefan Schwaiger, Hermann Stuppner
Activity guided isolation of a methanolic extract of the aerial plant parts of Wulfenia carinthiaca Jacq. (Plantaginaceae), using a mushroom tyrosinase assay, resulted in the isolation of five phenylethanoid glucosides and four iridoid glycosides. Two of those, 2'-O-acetylisoplantamajoside and 2',6''-O-diacetylisoplantamajoside, represent new natural products. Evaluation of the inhibitory activity of all isolated compounds revealed that the observed activity is not related to the isolated phenylethanoid glycosides but mainly due to the presence of the iridoid glycoside globularin (IC50 41...
March 9, 2018: Chemistry & Biodiversity
G Capillo, S Silvestro, M Sanfilippo, E Fiorino, G Giangrosso, V Ferrantelli, I Vazzana, C Faggio
Faro Lake is a coastal meromictic lagoon with singular characteristics in the Mediterranean (Messina, Sicily - Italy). It is part of the Natural Oriented Reserve of Capo Peloro (38°15'57" N; 15° 37'50" E). In this area, traditional mollusc farming activity persists, producing "autochthonous" mussels. This study reports of the Mytilus galloprovincialis haemolymph chemical profile and water variables determination of one year-lasted survey (April 2016-March 2017). The determinations of electrolytes (Na+, Cl-, K+, Ca2+, Mg2+, P inorganic) and heavy metals in both Faro lake water and haemolymph have been carried out...
March 9, 2018: Chemistry & Biodiversity
Silvia Giovanelli, Marinella De Leo, Claudio Cervelli, Barbara Ruffoni, Daniela Ciccarelli, Luisa Pistelli
Helichrysum genus consists of about 600 species widespread throughout the world, especially in South Africa and in the Mediterranean area. In this study the aroma profile (HS-SPME) and the EO compositions of seven Helichrysum species (H. cymosum, H. odoratissimum, H. petiolare, H. fontanesii, H. saxatile, H. sanguineum and H. tenax) were evaluated. All the plants were grown in Italy under the same growth conditions. The volatile constituents, particularly monoterpenes, depended by the plant's genotype and ecological adaptation...
March 6, 2018: Chemistry & Biodiversity
Rafika Brakni, Monia Ali Ahmed, Pauline Burger, Aurélie Schwing, Grégory Michel, Christelle Pomares, Lillia Hasseine, Laurent Boyer, Xavier Fernandez, Anne Landreau, Thomas Michel
Lichens are complex symbiotic organisms able to produce a vast array of compounds. The Algerian lichen diversity has only prompted little interest even given the 1085 species listed. Herein, the chemodiversity of four Algerian lichens including Cladonia rangiformis, Ramalina farinaceae, R. fastigiata and Roccella phycopsis was investigated. A dereplication strategy, using ultra high performance liquid chromatography-electrospray ionization-high resolution mass-spectrometry (UHPLC-ESI-HRMS/MS), was carried out for a comprehensive characterization of their substances including phenolics, depsides, depsidones, depsones, dibenzofurans and aliphatic acids...
March 5, 2018: Chemistry & Biodiversity
Qi-Zhe Gong, Di Xiao, Feng Feng, Xiao-Dong Wen, Wei Qu
Ent-sauchinone, a lignan isolated from Saururus chinensis (Lour.) Bail, was reported that it could modulate the expression of Signal transducer and activator of transcription 3 (STAT3). Since STAT3 plays a key role in invasion, migration and metastasis of cancer, we investigated whether ent-sauchinone could exert promising inhibitory effects on the invasion and migration of the metastatic human liver cancer cell line SMMC-7721 in the present study. Ent-sauchinone was extracted from dried herbs of Saururus chinensis (Lour...
March 1, 2018: Chemistry & Biodiversity
Yeong-Geun Lee, Seon-A Jang, Kyeong-Hwa Seo, Jung Eun Gwag, Hyoung-Geun Kim, Jung-Hwan Ko, So-Ae Ji, Se-Chan Kang, Dae Young Lee, Nam-In Baek
Six lignans including two new lignans were obtained as the principal components of the Forsythia koreana flowers via silica gel (SiO2 ), octadecyl SiO2 (ODS) as well Sephadex LH-20 column chromatography. In addition to two new lignans, named koreanaside A ((7R,8S,7'R,8'S)-5'-hydroxy-3,3'-dimethoxy-7,7'-diepoxylignan 4-O-β-D-glucopyranoside) and koreanaside B ((7R,8S,7'S,8'R)-9,5',7'-trihydroxy-3,3'-dimethoxy-7,9'-epoxylignan 4-O-β-D-glucopyranoside), four known lignans were identified to be (+)-phylligenin, (-)-epipinoresinol, pinoresinol, and tinosposide A...
March 1, 2018: Chemistry & Biodiversity
Huiling Wen, Xiaorui Liu, Qing Zhang, Yanfang Deng, Yi Zang, Jianping Wang, Junjun Liu, Qun Zhou, Linzhen Hu, Hucheng Zhu, Chunmei Chen, Yonghui Zhang
Asperochramides A-D (1-4), a new natural product and three new indole diketopiperazine alkaloids, along with seven known analogues (5-11), were isolated from the ethyl acetate (EtOAc) extract of Aspergillus ochraceus. Their structures were elucidated by extensive spectroscopic analyses, ECD calculation, and single-crystal X-ray diffraction analysis. Compounds 3 and 4 represent a rare group of indole diketopiperazine alkaloids with a 3-hydroxyl-2-indolone moiety. The in vitro anti-inflammatory effects of compounds 1 and 3-11 were investigated by using LPS-stimulated murine macrophage RAW 264...
February 26, 2018: Chemistry & Biodiversity
Julie Charpentier, Roger Emter, Heinz Koch, Dominique Lelièvre, Xavier Pannecoucke, Samuel Couve-Bonnaire, Andreas Natsch, Agnes Bombrun
A series of three α- and three β-fluorinated representatives of the family of cinnamate-derived odorants (cinnamaldehyde (1), cinnamyl alcohol (2) and ethyl cinnamate (3)) used as fragrance ingredients is described. Olfactive evaluation shows that the fluorinated compounds exhibit a similar odor profile to their parent compounds, but the olfactive detection thresholds are clearly higher. In vitro evaluation of the skin sensitizing properties with three different assays indicates that α-fluorination of Michael acceptor systems 1 and 3 slightly improves the skin sensitization profile...
February 24, 2018: Chemistry & Biodiversity
Chonlatid Somtimuang, Opeyemi Joshua Olatunji, Chitchamai Ovatlarnporn
The sporadic increase in the occurrence and prevalence of diabetes mellitus have compelled and vigorous search for alternative anti-diabetic therapeutic approach from medicinal plants and its bioactive. One of the major approach employed is the reduction of gastrointestinal glucose levels through the inhibition of carbohydrate digesting enzymes notably α-amylase and α- glucosidase. In this study, the ethanol extracts of 14 selected plants from Mor Porn's recipe were screened for their α-amylase and α- glucosidase inhibitory activity...
February 20, 2018: Chemistry & Biodiversity
Yin-Ru Wang, Yun Yu, Shu-Ming Li, Wei Liu, Wei Li, Susan L Morris-Natschke, Masuo Goto, Kuo-Hsiung Lee, Xue-Feng Huang
Using various chromatographic methods, a new hexacyclic triterpenoid, 2β, 3β, 24β-trihydroxy-12, 13-cyclo-taraxer-l4-en-28oic acid (1), together with ten known compounds, 2α, 3α, 23- trihydroxyurs-12, 20(30)-dien-28oic acid (2), 6, 7-dehydroroyleanone (3), horminone (4), 7-O-methylhorminone (5), sugiol (6), demethylcryptojaponol (7), 14-deoxycoleon U (8), 5, 6-didehydro-7-hydroxy-taxodone (9), ferruginol (10) and dichroanone (11), were isolated from the roots of Salvia deserta. Their structures were identified on the basis of spectroscopic analysis and comparison with the reported data...
February 16, 2018: Chemistry & Biodiversity
Yani Guo, Xiufeng Wang, Jing Gao
In this study, epimedin A-, B- and C- and icariin-rich extracts were simultaneously prepared from Epimedium brevicornu Maxim (E. brevicornu) through a convenient four-stage process consisting of solvent extraction, macroporous resin column pre-concentration, extraction fractionation and reversed-phase (RP)-silica gel column chromatography. Single factor experiments and response surface methodology (RSM) were used to optimize the preparation conditions. In the final products, the purity of epimedin A, B and C and icariin were 23...
February 16, 2018: Chemistry & Biodiversity
Agustín Maceda, Marcos Soto-Hernández, Cecilia B Peña-Valdivia, Teresa Terrazas
The aims of this study were to determine the wood chemical composition of 25 species of Cactaceae and to relate the composition to their anatomical diversity. The hypothesis was that wood chemical components differ in relationship to their wood features. The results showed significant differences in wood chemical compounds across species and genera (p < 0.05). Pereskia had the highest percentage of lignin, whereas species of Coryphantha had the lowest; extractive compounds in water were highest for Echinocereus, Mammillaria and Opuntia...
February 14, 2018: Chemistry & Biodiversity
Amira Arciniegas, Ana-L Pérez-Castorena, Mariana Meléndez-Aguirre, José Guillermo Ávila, Ana María García-Bores, José Luis Villaseñor, Alfonso Romo de Vivar
The chemical study of Ageratina deltoidea afforded grandiflorenic acid (1), kaurenoic acid (2) and eight benzylbenzoates (3 - 10), two of them, 3',5'-dimethoxybenzyl 2,3,6-trimethoxybenzoate (5) and 4'-O-β-ᴅ-glucopyranosyloxy-3'-hydroxybenzyl 2,6-dimethoxybenzoate (9), described for the first time. In addition, the new sesquiterpene lactone deltoidin C (13), together with the known 11, and 12, the phenolic compounds: ayanin, 2,6-dimethoxybenzoic acid, methyl 3,4-dihydroxycinnamate, chlorogenic acid, and 3,5-dicaffeoylquinic acid were also isolated...
February 10, 2018: Chemistry & Biodiversity
K V Nithyamol, Dwaipayan Bhattacharya, Sumana Chakravarty, U V Mallavadhani
Systematic chemical screening of the leaves ofBruguiera cylindrica, the tree mangrove of Rhizophoraceae family, afforded five single and purecompounds. Thestructures of the isolated compounds were established by their spectroscopic data astaraxerol (1), 3β-(E)-coumaroyltaraxerol (2), 3β-(Z)-coumaroyltaraxerol (3),β-sitosterol (4) and eicosanol (5).In view of significant accumulation and interesting biological activities, taraxerol (1) was chemically transformed to synthesize a series of ten cinnamyl esters in very good to excellent yields...
February 8, 2018: Chemistry & Biodiversity
Nada M Mostafa, Eman A Abd El-Ghffar, Hoda G Hegazy, Omayma A Eldahshan
Flavonoids are agents with strong antioxidant properties and ameliorate many diseases associated with oxidative stress. Leaves of Casimiroa sapota (CS) was investigated for components and anti-inflammatory activities against lead acetate (PbAc) induced hepatotoxicity in rats. Two groups of male albino rats were administrated orally CS (100 and 200 mg/kg b.w/day) for 28 days; other group was injected with sub-acute dose (100 mg/kg b.w/day) of PbAc. Three protective groups were injected with PbAc (100 mg/kg b...
February 6, 2018: Chemistry & Biodiversity
Saghi Sepehri, Sepehr Soleymani, Rezvan Zabihollahi, Mohammad R Aghasadeghi, Mehdi Sadat, Lotfollah Saghaie, Hamid R Memarian, Afshin Fassihi
A series of tetrahydropyrimidine derivatives (2a-l) were designed, synthesized and screened for anti-HIV-1 properties based on the structures of HIV-1 gp41 binding site inhibitors, NB-2 and NB-64. A computational study was performed to predict the pharmacodynamics, pharmacokinetics and drug-likeness features of the studied molecules. Docking studies revealed that the carboxylic acid group in the molecules forms salt bridges with either Lys574 or Arg579. Physiochemical properties (e.g. molecular weight, number of hydrogen bond donors, number of hydrogen bond acceptors and number of rotatable bonds) of the synthesized compounds confirmed and exhibited that these compounds were within the range set by Lipinski's rule of five...
February 6, 2018: Chemistry & Biodiversity
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