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Chemistry & Biodiversity

Ram S Verma, Neeta Joshi, Rajendra C Padalia, Ved R Singh, Prakash Goswami, Ajay Kumar, Hina Iqbal, Rajesh K Verma, Debabrata Chanda, Amit Chauhan, Dharmendra Saikia
Fish-mint (Houttuynia cordata Thunb.), belongs to family Saururaceae has long been used as food and traditional herbal medicine. The present study was framed to assess the changes occurring in the essential-oil composition of Houttuynia cordata during annual growth and to evaluate allelopathic, antibacterial, antifungal and antiacetylcholinesterase activities. The essential-oil content ranged from 0.06-0.14% and 0.08-0.16% in aerial-parts and underground-stem, respectively. The essential oils were analysed by GC-FID, GC-MS and NMR ((1) H & (13) C)...
June 21, 2017: Chemistry & Biodiversity
Yijie Sha, Xu Chen, Bing Niu, Qin Chen
Quercetin, a ubiquitous flavanoid, has numerous pharmacological effects, such as antioxidant and antitumor. Previous studies showed nucleic acids were the potential biological targets for antitumor medicine. For exploring the mechanism of DNA-target medicine, the interaction between quercetin and calf thymus DNA was studied based on the method of spectrometry and simulation in our study. Firstly, the interaction between quercetin and calf thymus DNA was confirmed by fluorescence spectrometry. Furthermore, circular dichroism, fluorescence polarization, competitive displacement assay and salt concentration dependence assay were applied to search the interaction mode of quercetin-calf thymus DNA, which proved the existence of groove binding and electrostatic interaction...
June 20, 2017: Chemistry & Biodiversity
M Letizia Ciavatta, Stella García-Matucheski, Marianna Carbone, Guido Villani, Claudia Muniain, Margherita Gavagnin
The lipophilic extracts of two marine aeolid nudibranch molluscs of the genus Spurilla collected in distinct geographical areas have been chemically analysed. The Et2 O extracts of the nudibranchs were dominated by the presence of usual fatty acids and sterols and contained terpenoid compounds 1-3 as minor metabolites. Spurillin A (1) and spurillin B (3) were new molecules whereas cis-γ-monocyclo-farnesol (2) was already reported in the literature as a synthesis product. Interestingly, bursatellin (4), previously isolated from anaspidean molluscs of the genus Bursatella, was found in the butanol extract of both Spurilla species...
June 19, 2017: Chemistry & Biodiversity
Hui Ding, Jianan Wang, Dashan Zhang, Zhongjun Ma
On the basis of the one strain-many compounds (OSMAC) strategy, five compounds including two new holomycin derivatives (2-3), two new cyclopropaneacetic acid derivatives (4-5), together with one known compound holomycin (1) were isolated from a marine-derived bacterium Streptomyces sp. DT-A37. Their structures were elucidated using NMR and HRESIMS analyses. All these compounds were evaluated for their antimicrobial activity, cytotoxic activity, and inhibitory activity against BRD4 protein. Compound 1 exhibited potent cytotoxicity against H1975 cells with IC50 value of 1 μM, and its MIC values against Escherichia coli and Staphylococcus aureus were both 64 μM...
June 19, 2017: Chemistry & Biodiversity
Natalizia Miceli, Angela Filocamo, Salvatore Ragusa, Francesco Cacciola, Paola Dugo, Luigi Mondello, Marilena Celano, Valentina Maggisano, Maria Fernanda Taviano
The present work focused on the evaluation of the antioxidant and cytotoxic activities of the phenolic-rich fraction (ItJ-EAF) obtained from cauline leaves collected in January from Isatis tinctoria L. (Brassicaceae) grown wild around Acireale (Sicily, Italy). The total phenolic, flavonoid and condensed tannin contents of the fraction were determined spectrophotometrically, whereas the phenolic profile was assessed by HPLC-PDA-ESI-MS analysis. A total of 20 compounds were positively identified and 12 out of them were never previously reported in I...
June 16, 2017: Chemistry & Biodiversity
Abdul Latif, Yongle Du, Seema R Dalal, Emilio F Merino, Maria B Cassera, Michael Goetz, David G I Kingston
Bioassay-guided fractionation of a methanol extract of Magnolia grandiflora against Plasmodium falciparum yielded two new (1 and 2) and six known (3 - 8) bioactive compounds. The structures of the new compounds were assigned by mass spectrometric and 1D and 2D NMR data. Known compounds were identified by comparison of (1) H NMR and MS data with literature data. The two known neolignans 3 and 4 showed moderate antiplasmodial activity with IC50 values of 2.8 ± 0.1 and 3.4 ± 0.1 μM, respectively. Weak antiplasmodial activity was recorded for compounds 1, 2, 5, 6, 7 and 8, with IC50 values of 38 ± 2, 23 ± 2, 16...
June 16, 2017: Chemistry & Biodiversity
Lu Wang, Yanan Wu, Tao Huang, Kan Shi, Zhenqiang Wu
Hydrodistilled essential oils (EO) of Psidium guajava L. leaves from different regions in China were analyzed by GC and GC/MS. The samples from Guangdong province displayed high EO yields (0.61-0.75%, v/w). A total of 50 components, representing over 98.00% of the EOs, were identified and semi-quantitatived. The major constituents of EOs included β-caryophyllen (17.17-31.38%), γ-gurjunene (9.17-15.22%), τ-cadinol (1.35-10.02%) and calamenene (2.13-7.80%). The terpenoids in all sample oils were dominated by sesquiterpenes hydrocarbons (70...
June 15, 2017: Chemistry & Biodiversity
Afifa Zardi-Bergaoui, Aymen Ben Nejma, Fethia Harzallah-Skhiri, Guido Flamini, Roberta Ascrizzi, Hichem Ben Jannet
The chemical composition, antioxidant, cytotoxic, anticholinesterase and anti-tyrosinase activities of the hydrodistilled essential oil of the aerial parts of Beta vulgaris subsp. Maritime (L.) Arcang. from Tunisia have been evaluated. The chemical composition of the oil (yield 0.037% (w/w)), determined by GC-FID and GC-MS is reported for the first time. Twenty five components, accounting for 98.1% of the total oil have been identified. The oil was characterized by a high proportion of oxygenated sesquiterpenes (39...
June 14, 2017: Chemistry & Biodiversity
Marwa Affes, Jawhar Fakhfakh, Ines Douad, Vincent Brieudes, Maria Halabalaki, Abdelfattah El Feki, Noureddine Allouche
This study was performed in the aim to evaluate 9 different extracts from Tunisian L. arabicum for their total phenolic (TPC) and total flavonoid (TFC) contents, phytochemical analyses as well as their antioxidant and anti-lipase activities. The in vitro antioxidant property was investigated using three complementary methods (DPPH, Ferric reducing antioxidant capacity (FRAP) and β-carotene-linoleic acid bleaching assays) while anti-lipase activity was evaluated using 4-methylumbelliferyl oleate method. From all of the tested extracts the most potent found to be the polar methanol extracts especially those of stems and leaves...
June 14, 2017: Chemistry & Biodiversity
Juan Li, Dan-Dan Wang, Xiao-Shuang Xu, Lu Bai, Bing Peng, Ya-Jie Pu, Hong-Ling Tian, Xue-Mei Qin, Fu-Sheng Zhang, Cun-Gen Ma
As one of the most important traditional Chinese medicine, the quality of Polygala tenuifolia is difficult to control and a new method must be established to facilitate/assist the breeding of P. tenuifolia. In this study, UPLC/Q-TOF MS-based metabolomics analysis was performed to determine the chemical composition and screen metabolite biomarkers according to agronomic traits. A total of 29 compounds and 18 metabolite biomarkers were found. AFLP-based marker-assisted selection (MAS) was used to identify molecular marker bands and screen characteristic bands associated with specific agronomic traits...
June 13, 2017: Chemistry & Biodiversity
Yang Zhao, Dong Liu, Peter Proksch, Siwang Yu, Wenhan Lin
TLC-DPPH guided fractionation of a sponge-associated fungus Truncatella angustata with a solid culture resulted in the isolation of five new α-pyrone-based analogues namely angupyrones A-E (1-5), and 3-enthyl-4-hydroxy-6-methyl-2-pyrone. Their structures were determined on the basis of extensive spectroscopic analyses, including the modified Mosher's method, bulkiness rule and specific rotation for the configurational assignments. Angupyrones A-E exhibited moderate antioxidant response element (ARE) activation in HepG2C8 cells, while the preliminary structure-activity relationship was discussed...
June 9, 2017: Chemistry & Biodiversity
Erik Krošlák, Tibor Maliar, Peter Nemeček, Jana Viskupičová, Mária Maliarová, Michaela Havrlentová, Ján Kraic
Poppy seeds (Papaver somniferum L.) belong to tasty food ingredients however, they should be considered also as valuable source of biologically active compounds. Content of selected metabolites, antioxidant and proteinase inhibitory activities were analyzed in vitro in extracts from seeds of fifteen poppy genotypes. Considerable variation in all parameters was detected within the set of analyzed poppy genotypes. The genotype Major expressed the highest antioxidant activity determined by all four methodological approaches (DPPH, ABTS, FRAP, RP)...
June 9, 2017: Chemistry & Biodiversity
Mila Radan, Ivana Carev, Vele Tešević, Olivera Politeo, Vedrana Čikeš Čulić
Centaurea ragusina L., an endemic Croatian plant species, revealed a good cytotoxic activity of aqueous extracts on human bladder (T24) and human glioblastoma (A1235) cancer cell lines. The chemical constituents were tentatively identified using high performance liquid chromatography HPLC-DAD-ESI-TOF-MS in negative ionization mode. The main compounds of herba extract were sesquiterpene lactones: solstitialin A-3, 13 diacetate and epoxyrepdiolide; organic acid: quinic acid. The main compounds of flower extract were organic acids: quinic acid, citric acid and malic acid; sesquiterpene lactone: cynaropicrin; phenolic compounds: chlorogenic acid and phenylpropanoid: syringin...
June 7, 2017: Chemistry & Biodiversity
Ana Valentina Basso, Segundo Leiva González, Gloria Estela Barboza, Valeria Pilar Careaga, Juan Carlos Calvo, Paula A Sacca, Viviana Estela Nicotra
Twelve Salpichroa taxa have been phytochemically analyzed. From the aerial parts of S. scandens, the four known salpichrolides A, C, I, S, and an unreported withanolide named salpichrolide V (1), were isolated. In S. dependens, S. gayi, S. glandulosa subsp. glandulosa, S. glandulosa subps. weddellii, S. leucantha, S. micrantha, S. microloba, S. proboscidea, S. ramosissima, S. tristis var. tristis, and S. weberbauerii, no withanolides were found. The chemical content of ca. 85 % of the Salpichroa taxa is in agreement with molecular studies, which suggest that Salpichroa and Jaborosa, a genus considered morphologically close to Salpichroa, are distant in the systematic of the Solanoideae subfamily...
June 5, 2017: Chemistry & Biodiversity
Aamer Saeed, Parvez Ali Mahesar, Pervaiz Ali Channar, Fayaz Ali Larik, Qamar Abbas, Mubashir Hassan, Hussain Raza, Sung-Yum Seo
The current research article reports the synthesis of coumarinyl pyrazolinyl thioamide derivatives and their biological activity as inhibitors of jack bean urease. The coumarinyl pyrazolinyl thioamides were synthesized by reacting thiosemicarbazide with newly synthesized chalcones to afford the products in good yields and the synthesized compounds were purified by recrystallization. Coumarinyl pyrazolinyl thioamide derivatives 5a-5q showed significant activity against Urease enzyme and also exhibited good antioxidant potential...
June 2, 2017: Chemistry & Biodiversity
Yui Akihara, Emi Ohta, Tatsuo Nehira, Hisashi Ômura, Shinji Ohta
Two new prenylated ortho-dihydroxycoumarins, designated fipsomin (1) and fipsotwin (2), were isolated from the fruits of Ficus nipponica together with a known prenylated coumarin, apigravin (3). Their structures were established by spectroscopic data and X-ray crystallographic analysis. Compound 1 exhibited antibacterial activity against Bacillus subtilis with an MIC value of 61 μM, while 2 and 3 showed very weak activity. This article is protected by copyright. All rights reserved.
June 2, 2017: Chemistry & Biodiversity
By Jing Liu, Dengwu Li, Dongmei Wang, Yu Liu, Huiying Song
The allelopathic effects of Juniperus rigida litter aqueous extract (LE) on wheat and Pinus tabuliformis were studied, as well as the physiological responses to the extract. High concentration LE (0.10 g Dw·mL(-1) ) significantly inhibited the seed germination and seedling growth in receptor plants. The chlorophyll content and root activity in the wheat seedlings were reduced significantly across all treatments; however, those were more prominently reduced at high concentration (0.10 g Dw·mL(-1) ) but received little stimulation at low concentration (0...
May 30, 2017: Chemistry & Biodiversity
Miriam Heinrich, Peter Lorenz, Rolf Daniels, Florian C Stintzing, Dietmar R Kammerer
Seeds of Hypericum perforatum and H. tetrapterum were extracted with dichloromethane and methanol and investigated by chromatographic and mass spectrometric methods. Both species yielded a fatty oil fraction amounting to 30.5% and 18.0% of the seed weight, respectively. Linoleic acid (C18:2n-6) was shown to be the predominant fatty acid constituent. Moreover, xanthone derivatives, i.e. tetrahydroxyxanthones (THX), xanthone-glycosides and xanthone-sulfonates, were assigned in methanolic extracts. For structure elucidation, one representative xanthone, namely 1,3,6,7-THX, was synthesized and analyzed via HPLC-DAD-MS(n) and GC-MS...
May 29, 2017: Chemistry & Biodiversity
Emilia Kiuru, Suvi Malmikare, Mikko Ora
Protected dinucleoside-2',5'-monophosphate has been prepared to develop a prodrug strategy for 2-5A. The removal of enzymatically and thermally labile 4-acetylthio-2-ethoxycarbonyl-3-oxo-2-methylbutyl phosphate protecting group and enzymatically labile 3'-O-pivaloyloxymethyl group was followed at pH 7.5 and 37°C by HPLC from the fully protected dimeric adenosine-2',5'-monophosphate 1 used as a model compound for 2-5A. The desired unprotected 2',3'-O-isopropylideneadenosine-2',5'-monophosphate (9) was observed to accumulate as a major product...
May 29, 2017: Chemistry & Biodiversity
Elena A Vasileva, Natalia P Mishchenko, Sergey A Fedoreyev
Using high-performance liquid chromatography with diode-array detection and mass spectrometry (HPLC-DAD-MS) we investigated the composition of polyhydroxynaphthoquinone (PHNQ) pigments from sea urchins Strongylocentrotus pallidus, St. polyacanthus, St. droebachiensis, Brisaster latifrons and Echinarachnius parma, collected in the Sea of Okhotsk and the Bering Sea. Identification of PHNQ pigments from sea urchins St. polyacanthus, B. latifrons, and E. parma was performed for the first time. Among the usual PHNQ pigments, mono- and dimethoxy derivatives of spinochrome E, not previously found in other sea urchins, were discovered in St...
May 29, 2017: Chemistry & Biodiversity
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