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Chemistry & Biodiversity

Jie Zhang, Wan-Fang Zhu, Wei-Yuan Zhu, Pan Pan Yang, Jian Xu, Jiradej Manosroi, Takashi Kikuchi, Masahiko Abe, Toshihiro Akihisa, Feng Feng
A new steroid, 20-hydroxyisofucosterol (stigmasta-5,24(28)-diene-3β,20β-diol) (7), along with six known compounds 1 - 6 were isolated from the MeOH extract of the leaves of Sauropus androgynus L. Merr. (Euphorbiaceae). The structure of new steroid was determined by HR-APCI-MS and various NMR techniques in combination with literature data. Subsequently, their anti-inflammatory, cytotoxic activities against five human cell lines, as well as inhibitory activities against the α-MSH induced melanogenesis on the B16 cell line were evaluated...
November 16, 2017: Chemistry & Biodiversity
Ran Chen, Dong Liu, Peng Guo, Wenhan Lin
Chemical examination of a coral-associated fungus Aspergillus versicolor LZD-44-03 resulted in the isolation of two new compounds with the trivial names of varicuothiols A (1) and B (2) as a unique scaffold. Their structures were determined through extensive spectroscopic analyses in association with the modified Mosher's method and chemical conversion. Both 1 and 2 exhibited significant inhibition against LPS-induced RAW24.7 cell proliferation, in association with the down regulation of nitrite production and cytokines (MCP-1, IL-6, and TNF-α)...
November 16, 2017: Chemistry & Biodiversity
Hong-Mei Li, Xue-Jiao Chen, Dan Luo, Min Fan, Zhi-Jun Zhang, Li-Yan Peng, Xing-De Wu, Rong-Tao Li, Xu Ji, Qin-Shi Zhao
Twenty-eight protostane triterpenoids, including a new degraded one (1), nine new ones (2-10) and two new natural ones (11 and 12), have been isolated from the dried rhizomes of Alisma orientale. Alisol R (1) was the first 20,21,22,23,24,25,26,27-octanorprotostane triterpenoid. The absolute configurations of 25-methoxyalisol F (2) and 16β-hydroperoxyalisol B 23-acetate (3) were determined by X-ray diffraction analysis. In addition, alismaketone-B 23-acetate (28) showed potent vasorelaxant activity on endothelium-intact thoracic aorta rings precontracted with KCl...
November 15, 2017: Chemistry & Biodiversity
Yixing Chen, Chao Liu, Nan Liu, Ye Wu, Qingjie Zhao, Honggang Hu, Xiang Li, Yan Zou
As natural-product-derived antibiotics, Desotamides A-D and wollamides exhibit growth inhibitory activity against Gram-posivite bacteria (IC50 0.6-7 μM) and are noncytotoxic to mammalian cells (IC50 >30 μM). Herein we firstly report the total synthesis of above two cyclohexapeptides as well as a series of structural variants through solid phase peptide synthesis (SPPS), of which DE-3 displayed a 2-fold increase of anti-bacterial activity when compared with the original peptide DE-1. This strategy may offer good improvements for the synthesis of other cyclic peptides...
November 10, 2017: Chemistry & Biodiversity
Ana P de Oliveira, Juliana S Coppede, Bianca W Bertoni, Antônio E M Crotti, Suzelei C França, Ana Maria S Pereira, Silvia H Taleb-Contini
Costus spiralis, a plant used in traditional Brazilian medicine for the treatment of complications in diabetes, was investigated. Assay of hexane, ethyl acetate, methanol and aqueous fractions obtained by partition of a crude methanol extract of dried leaves of C. spiralis revealed that AGI activity was confined to the ethyl acetate fraction. Purification of this fraction yielded schaftoside and isoschaftoside. The AGI activities of the two flavones were lower than, but comparable with, that of the anti-diabetic drug acarbose...
November 10, 2017: Chemistry & Biodiversity
Abdul Rehman Phull, Mubshir Hassan, Qamar Abbas, Hussain Raza, Ihsan Ul Haq, Sung Yum Seo, Song Ja Kim
Urease enzyme plays a crucial role in the survival of Helicobacter pylori that contributes to different diseases, including peptic ulcer. Coagulansin-A is the steroidal lactone found in plants of solanaceae family such Withania coagulans. The current study was carried out to examine the in vitro urease, COX-2 inhibitory activity and effect on type II collagen expression of coagulansin-A. Moreover, we investigated cytotoxic effects on rabbit articular chondrocytes through MTT assay. COX-2 and type II collagen expressions were determined through a western blotting...
November 9, 2017: Chemistry & Biodiversity
Maurice D Awouafack, Pierre Tane, Hiroyuki Morita
A new cerebroside, named as tricalycoside (1), was isolated from the CH2 Cl2 / MeOH (1:1) extract of twigs and leaves of Tricalysia coriacea using repeated silica gel open column chromatography followed by Prep. TLC and Sephadex LH-20, together with six known compounds (2 - 7). The structure of the new compound was determined by analysis of 1D and 2D NMR, MS data, chemical conversion, and by comparison of these data with those from the literature. Tricalycoside (1) possessed a weak antibacterial activity against Klebsiella pneumoniae (MIC = 75 μg/mL)...
November 8, 2017: Chemistry & Biodiversity
Dan Wang, Jibiao Wang, Dujun Wang, Xiaofeng Yu, Opeyemi Joshua Olatunji, Zhen Ouyang, Yuan Wei
The current study was aimed at investigating the neuroprotective effects of the butanol fraction from C. cicadae (CBU ), which was responsible for the anti-aging effect of this medicine. Glutamate-induced PC12 cells were used as a model to determine the neuroprotective effect against oxidative cell death. Cell viability, cytotoxicity, flow cytometry, mitochondrial transmembrane potential (MMP), reactive oxygen species (ROS), glutathione peroxidase (GSH-Px) and superoxide dismutase (SOD) levels were analyzed to assess neuronal cell survival or death...
November 7, 2017: Chemistry & Biodiversity
Eder L Silva, Rita C Almeida-Lafetá, Ricardo M Borges, Dan Staerk
Athenaea (Solanaceae) is an endemic genus belonging to the Brazilian Atlantic Rainforest. Recently, botanical investigations suggested the re-evaluation of the generic status of the genus Athenaea as a synonym of Aureliana. In this study, the first investigation of the Athenaea genus performed on Athenaea martiana by means of HPLC-HRMS-SPE-NMR combined with high-resolution radical scavenging profile led to identification of several phenolic acids as radical scavengers: protocatechuic acid (1), 4-hydroxybenzoic acid (2), caffeic acid (3), vanillic acid (4) and ferulic acid (6)...
November 1, 2017: Chemistry & Biodiversity
Laura P Patiño C, Rodrigo Quintana Manfredi, Miriam Pérez, Mónica García, Guillermo Blustein, Ralf Cordeiro, Carlos D Pérez, Laura Schejter, Jorge A Palermo
Three azulenoid sesquiterpenes (1- 3) were isolated from the Antarctic gorgonian Acanthogorgia laxa collected by bottom trawls at -343 m. Besides linderazulene (1), and the known ketolactone 2, a new brominated C-16 linderazulene derivative (3) was also identified. This compound has an extra carbon atom at C-7 of the linderazulene framework. The antifouling activity of compounds 1 and 2 was assayed in the laboratory with Artemia salina larvae, and also in field tests, by incorporation in soluble-matrix experimental antifouling paints...
November 1, 2017: Chemistry & Biodiversity
Claudia Herrera, Vladimir Morocho, Giovanni Vidari, Carlo Bicchi, Gianluca Gilardoni
This paper reports the chemical composition of the essential oils obtained by hydrodistillation of male and female H. scabrum fresh leaves. The essential oils, HSMO and HSFO, respectively, were analyzed by GC-MS and GC-FID. A total of 93 components were detected, accounting for 94.8% and 95.3% of HSMO and HSFO, respectively. The prevalent constituents of HSMO were pinocarvone (13.1%), D-germacren-4-ol (12.6%), 1,8-cineole (10.8%), α-pinene (6.4%), and β-pinene (4.8%), whereas the major components of HSFO were 1,8-cineole (20...
October 31, 2017: Chemistry & Biodiversity
Ali Medbouhi, Nadjiya Merad, Abdelmounaim Khadir, Mourad Bendahou, Nassim Djabou, Jean Costa, Alain Muselli
The chemical composition, antibacterial and antioxidant activities of the essential oil obtained from Eryngium triquetrum from Algeria were studied. The chemical composition of sample oils from 25 locations was investigated using GC-FID and GC/MS. Twenty-four components representing always more than 87% were identified in essential oils from total aerial parts of plants, stems, flowers and roots. Falcarinol is highly dominant in the essential oil from the roots (95.5%). The relative abundance of falcarinol in the aerial parts correlates with the phenological stages of the plant...
October 30, 2017: Chemistry & Biodiversity
Fu-Sheng Zhang, Qian-Yu Wang, Ya-Jie Pu, Tong-Yao Chen, Xue-Mei Qin, Jie Gao
Sophora japonica is a traditional Chinese medicinal ingredient that is widely used in the medicine, food, and industrial dye industries. Since flavonoids are the main components of S. japonica, studying the flavonoid composition and content of this plant is important. This study aimed to identify molecules involved in the flavonoid biosynthetic pathways in S. japonica. Deep sequencing was performed, and 85,877,352 clean reads were filtered from 86,095,152 raw reads. The clean reads were spliced to obtain 111,382 unigenes, which were then annotated with NR, GO, KEGG, eggNOG...
October 30, 2017: Chemistry & Biodiversity
Ahmed M Abd El-Gawad, Yasser A El-Amier, Giuliano Bonanomi
Aromatic plants attract the attention of many researchers worldwide due to their worthy applications in agriculture, human prosperity, and the environment. Essential oil (EO) could be exploited as effective alternatives to synthetic compounds as it has several biological activities including allelopathy. The EO from the aerial parts of Rhynchosia minima was extracted by hydro-distillation and investigated by gas chromatography/mass spectrometry (GC-MS). Different concentrations (50, 100, 150 and 200 μL L(-1) ) of the EO were prepared for investigation of their allelopathic potential on two weeds; Dactyloctenium aegyptium and Rumex dentatus...
October 24, 2017: Chemistry & Biodiversity
Surya N Meena, Mahesh S Majik, Sanjeev C Ghadi, Santosh G Tilve
Grewia nervosa is herbal plant used as traditional medicine for different purposes. Bioassay-guided chemical fractionation of G. nervosa roots resulted in an identification of two known and one new compound, named Microgrewiapine A, Homomicrogrewiapine and N-methyl-microcosamine respectively. Their structures were determined using combination of LC-HRMS, (1) H NMR and IR spectra analyses followed by comparison with those reported in the literature. The problematic separation of these alkaloids on traditional column chromatography (Silica gel, Octadecyl silane (ODS), Sephadex) was resolved by using HPLC method...
October 16, 2017: Chemistry & Biodiversity
Ahmet Kilic, Ismail Koyuncu, Mustafa Durgun, Ismail Ozaslan, İbrahim Halil Kaya, Ataman Gönel
The synthesis, spectroscopic properties and in vitro cytotoxicity activity of a series of various salen-based triboron complexes have been designed and prepared from hemi-salen (L1 H3 -L4 H3 ) ligands and BF3 .Et2 O or BPh3 under simple reaction conditions. The hemi-salen (L1 H3 -L4 H3 ) ligands and their BF2 or BPh2 chelating triboron complexes were characterized by means of NMR ((1) H, (13) C, (19) F and (11) B) spectra, FT-IR spectra, UV-Vis spectra, fluorescence spectra, mass spectra, melting point as well as elemental analysis...
October 15, 2017: Chemistry & Biodiversity
Li-Xia Wang, Yin-Dong Fang, Rui-Han Zhang, Fu-Cai Ren, Xing-Jie Zhang, Fei Wang, Wei-Lie Xiao
Three hitherto unknown compounds, including one new hispanane-type diterpenoid glucoside, namely viburnumoside (1), two new secoiridoid glucosides, 7α-galloyloxysweroside (2), and 7β-galloyloxysweroside (3), together with ten known compounds (4 - 13) were isolated from the ethanol extract of twigs and leaves of Viburnum cylindricum. Their structures were elucidated on the basis of extensive spectroscopic studies, and the absolute configuration of compound 1 was confirmed by the experimental and calculated electronic circular dichroism (ECD) data...
October 15, 2017: Chemistry & Biodiversity
Marta Ramírez, Norma Kamiya, Susana Popich, Yoshinori Asakawa, Alicia Bardón
Three new compounds, a bicyclogermacrene (1) and two 2,3-secoaromadendrane esters (2 and 3), together with (13S)-13-hydroxy-8,14-labdadiene (4), fusicogigantone B (5), 3α, 14-diacetoxy-2-hydoxybicyclogermacrene (6), fusicogigantone A (7), neofuranoplagiochilal (8), plagiochiline B (9), furanoplagiochilal (10), trans-nerolidol, spathulenol, α-tocopherol and (+) globulol were isolated from an Argentine collection of Plagiochila diversifolia. Their structures were elucidated by extensive mono and bidimensional NMR studies...
October 10, 2017: Chemistry & Biodiversity
Roman Pavela, Filippo Maggi, Kevin Cianfaglione, Maurizio Bruno, Giovanni Benelli
Apiaceae are aromatic herbs producing essential oils which are used on an industrial scale for various purposes. Notably, Apiaceae essential oils may replace synthetic insecticides keeping most of their efficacy and avoiding environmental pollution and human poisoning. In the present work, we explored the insecticidal potential of the essential oils from five Apiaceae taxa, namely Sison amomum, Echinophora spinosa, Heracleum sphondylium subsp. sphondylium, Heracleum sphondylium subsp. ternatum and Trachyspemum ammi, as well as their major constituents (sabinene, p-cymene, terpinolene, myristicin and thymol), against the filariasis vector Culex quinquefasciatus...
October 9, 2017: Chemistry & Biodiversity
Masanori Morimoto, Charles L Cantrell, Shabana Khan, Babu L Tekwani, Stephen O Duke
Thirty-seven phytophenolics and their synthetic analogues were evaluated for activity against two protozoal pathogens, Leishmania donovani and Plasmodium falciparum (D6 and W2 clones), respectively. 4,6-Dimethoxyaurone demonstrated the highest activity with IC50 values of 13.2 μM and 16.9 μM against L. donovani and P. falciparum (W2 clone), respectively, without undesired cytotoxicity against VERO cells. The moiety having two benzene rings was critical to maintain the antiprotozoal activities based on the observation that both coumaranones and chromones were inactive while other test compounds, including coumarans and aurones, remained active...
October 9, 2017: Chemistry & Biodiversity
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