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Chemistry & Biodiversity

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https://www.readbyqxmd.com/read/28805955/structural-modification-of-stilbenoids-from-acanthopanax-leucorrhizus-and-their-cytotoxic-activity
#1
Hu Hao-Bin, Liang Hai-Peng, Li Hai-Ming, Yuan Ru-Nan, Sun Jiao, Wu Yun, Zhang La-La, Han Ming-Hu
A new cis-stilbenoid, 1,9-dihydroxy-10-methoxy-6H-dibenzo [b, f] oxocin-6-one (2) was isolated from the EtOAc extract of the stem barks of Acanthopanax leucorrhizus, along with three known stilbenoids, 9-hydroxy-10- methoxy-6H-dibenzo [b, f] oxocin-6-one (1), 5-O-methyl-(E)-resveratrol 3-O-β-D-glucopyranoside (3) and (E)- resveratrol 3-O-β-D-xylopyranoside (4). Two derivatives (2a and 2b) were synthesized by the structural modification of compound 2, which exhibited certain cytotoxic activities against HT-29 and Hela cell lines in vitro...
August 14, 2017: Chemistry & Biodiversity
https://www.readbyqxmd.com/read/28805952/constituents-from-scutellaria-barbata-inhibiting-nitric-oxide-production-in-lps-stimulated-microglial-cells
#2
So Ra Lee, Min-Suk Kim, Sunggun Kim, Kwang Woo Hwang, So-Young Park
The arial parts of Scutellaria barbata D. Don (Lamiaceae) efficiently inhibited NO production in BV2 microglial cells, and the active constituents were further isolated based on activity-guided isolation using silica-gel column chromatography, RP-C18 MPLC and prep-HPLC. As the results, 2 flavonoids including 6-methoxynaringenin (1) and 6-O-methylscutellarein (5), and 6 neo-clerodane diterpenes such as scutebarbatine W (2), scutebatas B (3), scutebarbatine B (4), scutebarbatine A (6), 6-O-nicotinolylscutebarbatine G (7) and scutebarbatine X (8) were isolated...
August 14, 2017: Chemistry & Biodiversity
https://www.readbyqxmd.com/read/28801935/biocidal-potential-and-chemical-composition-of-industrial-essential-oils-from-hyssopus-officinalis-lavandula-x-intermedia-var-super-and-santolina-chamaecyparissus
#3
Gonzalo Ortiz de Elguea-Culebras, Raúl Sánchez-Vioque, María Isabel Berruga, David Herraiz-Peñalver, Azucena González-Coloma, María Fé Andrés, Omar Santana-Méridas
This work presents the biocidal (insecticidal, ixodicidal, nematicidal and phytotoxic) effects and chemical compositions of three essential oils obtained from the industrial steam distillation (IEOs) of hyssop (Hyssopus officinalis L.), lavandin (Lavandula x intermedia or L. x hybrida var. Super) and cotton lavender (Santolina chamaecyparissus L.). Their chemical composition analyzed by gas chromatography coupled to mass spectrometry showed 1,8-cineole (53%) and β-pinene (16%) as the major components of H...
August 12, 2017: Chemistry & Biodiversity
https://www.readbyqxmd.com/read/28796420/chaetochromones-a-c-three-new-polyketides-from-mangrove-plant-derived-endophytic-fungus-phomopsis-sp-scsio-41006
#4
Zhi-Ran Ju, Xiu-Ping Lin, Minke Li, Ying Wang, Yong-Qi Tian, Jun-Feng Wang, Juan Liu, Zhengchao Tu, Shi-Hai Xu, Yonghong Liu
Three new polyketides, chaetochromones A-C (1-3), together with a chromone (4), were isolated from the ethyl acetate extract of mangrove-derived fungus Phomopsis sp. SCSIO 41006. Their structures were elucidated by means of spectroscopic techniques (1D and 2D NMR, MS, UV and IR). The absolute configurations of the new compounds were established by CD data. This article is protected by copyright. All rights reserved.
August 10, 2017: Chemistry & Biodiversity
https://www.readbyqxmd.com/read/28795782/variation-on-composition-and-bioactivity-of-essential-oils-of-four-common-curcuma-herbs
#5
Lanyue Zhang, Zhiwen Yang, Dingkang Chen, Zebin Huang, Yongliang Li, Xinzi Lan, Ping Su, Wanyi Pan, Wei Zhou, Xi Zheng, Zhiyun Du
Chemical compositions, antioxidative, antimicrobial, anti-inflammatory and cytotoxic activities of essential oils extracted from four common Curcuma species (Curcuma longa, Curcuma phaeocaulis, Curcuma wenyujin and Curcuma kwangsiensis) rhizomes in China are comparatively studied. In total, 47, 49, 35 and 30 compounds are identified in C. longa, C. phaeocaulis, C. wenyujin and C. kwangsiensis essential oils by GC-MS, and their richest compounds are ar-turmerone (21.67%), elemenone (19.41%), curdione (40.23%) and (36...
August 10, 2017: Chemistry & Biodiversity
https://www.readbyqxmd.com/read/28792667/highly-enantioselective-production-of-chiral-secondary-alcohols-using-lactobacillus-paracasei-bd101-as-a-new-whole-cell-biocatalyst-and-evaluation-of-their-antimicrobial-effects
#6
Durmuşhan Yılmaz, Engin Şahin, Enes Dertli
Chiral secondary alcohols are valuable intermediates for many important enantiopure pharmaceuticals and biologically active molecules. In this work, we studied asymmetric reduction of aromatic ketones to produce the corresponding chiral secondary alcohols using lactic acid bacteria (LAB) as new biocatalysts. Seven LAB strains were screened for their ability to reduce acetophenones to their corresponding alcohols. Among these strains Lactobacillus paracasei BD101, was found to be the most successful at reducing the ketones to the corresponding alcohols...
August 9, 2017: Chemistry & Biodiversity
https://www.readbyqxmd.com/read/28772025/new-bioactive-macrocyclic-diterpenoids-from-euphorbia-helioscopia
#7
Juan Hua, Shi-Hong Luo, Yan Liu, Yan-Chun Liu, Yan-Yun Tan, Ling Feng, Chao-Jiang Xiao, Ke-Qin Zhang, Sheng-Hong Li, Xue-Mei Niu
Three new macrocyclic diterpenoids, euphoscopoids A-C (1-3), including two new jatrophanes and a new lathyrane, were isolated from the whole plant of Euphorbia helioscopia. Their structures were elucidated by spectroscopic methods. Antifeedant and cytotoxic activities of these isolates were evaluated. All compounds showed significant antifeedant activity against a generalist plant-feeding insect, Helicoverpa armigera, with EC50 values ranging from 2.05 to 4.34 μg/cm(2) . In addition, compound 2 showed moderate cytotoxicity against tumor cell lines NCI-H1975, HepG2 and MCF-2, while compounds 1 and 3 were not active at 80 μM...
August 3, 2017: Chemistry & Biodiversity
https://www.readbyqxmd.com/read/28771984/bioactive-secondary-metabolites-from-orchids-orchidaceae
#8
REVIEW
Stefania Sut, Filippo Maggi, Stefano Dall'Acqua
The Orchidaceae family is the largest group of flowering plants in the Angiosperm monocotyledons spread on our planet. Its members, called orchids, are herbs or epiphytes with showy flowers distributed mainly in tropical regions. Several classes of phytoconstituents have been so far isolated from therapeutically-used orchids showing a great chemical diversity. Among them, phenolic derivatives have been studied for their biological activities, especially in the field of cancer, inflammation and neurodegeneration...
August 3, 2017: Chemistry & Biodiversity
https://www.readbyqxmd.com/read/28749029/ecotype-variation-of-methyl-eugenol-content-in-tea-tree-melaleuca-alternifolia-and-m-linariifolia
#9
Mervyn Shepherd, Dale Savins, Ashley Dowell, Samantha Morrow, Gareth Allen, Ian Southwell
Methyl eugenol is a natural phenylpropanoid compound found in a wide range of plants used for food, flavouring, cosmetics and health-care. As a suspected rodent carcinogen, methyl eugenol may also be harmful to humans when present in significant concentrations. Consequently, its level has been restricted in some foodstuffs and cosmetics for some markets. In order to assess the potential to breed uniformly low methyl eugenol cultivars for an essential oil crop, tea tree, the source of "Oil of Melaleuca, terpinene-4-ol type", we examine levels in individual trees (n= 30) from two geographic regions and six terpene chemotypes...
July 27, 2017: Chemistry & Biodiversity
https://www.readbyqxmd.com/read/28746771/highly-enantioselective-production-of-chiral-secondary-alcohols-with-candida-zeylanoides-as-a-new-whole-cell-biocatalyst
#10
Engin Şahin, Enes Dertli
The increasing demand for biocatalysts in synthesizing enantiomerically pure chiral alcohols results from the outstanding characteristics of biocatalysts in reaction, economic, ecological issues. Herein fifteen yeast strains belonging to three food originated yeast species Candida zeylanoides, Pichia fermentans and Saccharomyces uvarum were tested for their capability for asymmetric reduction of acetophenone to 1-phenylethanol as biocatalysts. Of these strains, Candida zeylanoides P1 showed an effective asymmetric reduction ability...
July 26, 2017: Chemistry & Biodiversity
https://www.readbyqxmd.com/read/28746739/characterization-and-influence-of-green-synthesized-of-nano-sized-zinc-complex-with-5-aminolevulinic-acid-on-bioactive-compounds-of-aniseed
#11
Vahid Tavallali, Sadegh Rahmati, Vahid Rowshan
A new water soluble zinc-aminolevulinic acid nano complex (n[Zn(ALA)2 ]), which characterized by TEM, IR and EDX spectra, has been prepared via sonochemical method under green conditions in water. In the current study, the effectiveness of foliar Zn amendment using synthetic Zn-ALA nano complex, as a new introduced Zn-fertilizer here, was evaluated. As the model plant, Pimpinella anisum, the most valuable spice and medicinal plant grown in warm regions, was used. By using zinc nano complex, further twenty compounds were obtained in the essential oil of anise plants...
July 26, 2017: Chemistry & Biodiversity
https://www.readbyqxmd.com/read/28742251/evolution-of-volatile-emission-in-rhus-coriaria-organs-during-different-stages-of-growth-and-evaluation-of-the-essential-oil-composition
#12
Rose Vanessa Bandeira Reidel, Pier Luigi Cioni, Luigi Majo, Luisa Pistelli
Rhus coriaria, also known as sumac, have been traditionally used in many countries as spice, condiment, dying agent and medicinal herb. The chemical composition of essential oils and the volatile emissions from different organs of this species collected in Sicily (Italy) were analyzed by GC-FID and GC-MS. Monoterpene and sesquiterpene hydrocarbons were the most abundant class in the volatile emissions with β-caryophyllene and α-pinene were the main constituents in the majority of the examined samples. The EO composition was characterized by high amount of monoterpene and sesquiterpene hydrocarbons together with diterpenes...
July 25, 2017: Chemistry & Biodiversity
https://www.readbyqxmd.com/read/28737020/bioactive-pimarane-type-diterpenes-from-marine-organisms
#13
REVIEW
Xiaoli Wang, Haobing Yu, Yixin Zhang, Xiaoling Lu, Bin Wang, Xiaoyu Liu
Marine organisms represent an abundant sources of bioactive natural products with unique chemical structure. Pimarane diterpenes are a structurally diverse family of natural products with various biological activities and pharmacological properties. A prolific source of new marine-derived pimarane diterpenes have attracted considerable interest because of their unique structural diversity and varied biological activities, including antimicrobial, antitumor, and antiproliferative activities. This review provides a comprehensive overview of the structures, names, bioactivities, and references of 80 marine-derived pimarane-type natural products for the first time...
July 24, 2017: Chemistry & Biodiversity
https://www.readbyqxmd.com/read/28724201/variations-in-the-bioactive-compounds-composition-and-biological-activities-of-loofah-luffa-cylindrica-fruits-in-relation-to-maturation-stages
#14
Takoua Ben Hlel, Feten Belhadj, Fatih Gül, Muhammed Altun, Ayşe ŞahinYağlıoğlu, Ibrahim Demirtaş, M Nejib Marzouki
The present work aimed to determine the antioxidant and antiproliferative potential of Luffa cylindrica fruits collected at two different maturation stages and to identify and compare their functional components composition. The methanolic extracts of L. cylindrica fruits harvested at 60 to 65 days after seeding (S1) and 85 to 90 days after seeding (S2) were investigated for their antioxidant activity using various assays. Furthermore, the antiproliferative activity of the extracts against HeLa human cervical cancer cells was explored with xCELLigence real time cell analyzer while the effect of the samples on the membrane integrity of the same cell line was assessed using LDH cytotoxicity leakage assay...
July 19, 2017: Chemistry & Biodiversity
https://www.readbyqxmd.com/read/28724197/discrimination-and-characterization-of-two-mediterranean-species-from-the-laurencia-complex-rhodomelacea-using-an-nmr-based-metabolomic-approach
#15
Sylvain Sutour, Hélène Esselin, Ange Bighelli, Joseph Casanova, Line Le Gall, Félix Tomi
Generic and specific determination among the Laurencia complex is a challenging task. DNA barcoding combined with phenotypic investigations are mandatory for species differentiation. In this study, two morphologically different members of the Laurencia complex were investigated using untargeted (1) H NMR-based metabolomics. Twenty-one population samples were collected in order to evaluate both temporal and geographical homogeneity. Data obtained from (1) H NMR analysis followed by statistical analysis allowed a clear separation of all the samples into two groups...
July 19, 2017: Chemistry & Biodiversity
https://www.readbyqxmd.com/read/28719026/in-vitro-antiproliferative-and-antibacterial-activities-of-essential-oils-from-four-species-of-guatteria
#16
Anderson R Santos, Thalita Gilda S Benghi, Angelita Nepel, Francisco A Marques, Adriana Q Lobão, Marta Cristina T Duarte, Ana Lúcia T G Ruiz, João E Carvalho, Beatriz H L N S Maia
The essential oils extracted from four species of the genus Guatteria, G.australis, G. ferruginea, G. latifolia and G. sellowiana were analyzed. A total of 24, 22, 25 and 19 constituents of the oils from four species, respectively, were identified by GC-MS. These oils showed qualitative and quantitative differences. All the oils contained the oxygenated sesquiterpenes spathulenol (11.04 - 40.29%) and caryophyllene oxide (7.74 - 40.13%) as predominant constituents. Evaluation of antiproliferative activity of the essential oils showed strong selectivity (1...
July 18, 2017: Chemistry & Biodiversity
https://www.readbyqxmd.com/read/28710838/enzyme-free-ligation-of-5-phosphorylated-oligodeoxynucleotides-in-a-dna-nanostructure
#17
Markus Kramer, Clemens Richert
Multicomponent reactions are difficult synthetic transformations. For DNA, there is a special opportunity to align multiple strands in a folded nanostructure, so that they are preorganized to give a specific sequence. Multistrand reactions in DNA origami structures have previously been performed using photochemical crosslinking, 1,3-diploar cycloadditions or phosphoramidate-forming reactions. Here we report carbodiimide-driven phosphodiester formation in a small origami sheet that produces DNA strands up to 600 nucleotides in length in a single step...
July 15, 2017: Chemistry & Biodiversity
https://www.readbyqxmd.com/read/28704572/caryophyllane-thiols-vinyl-thioethers-di-and-bis-sulfides-antioxidant-and-membrane-protective-activities
#18
Yulia V Gyrdymova, Denis V Sudarikov, Oksana G Shevchenko, Svetlana A Rubtsova, Pavel A Slepukhin, Aleksandr V Kutchin
Caryophyllane thioterpenoids were synthesized in 23-81% yields. The antioxidant properties of the obtained compounds in various model systems were found. It was revealed that 4,5-epoxycaryophyll-9-ylmethanethiol has the greatest antioxidant activity. The isomerism of sesquiterpenic fragments was shown to have a significant effect on the biological activity of the compounds. This article is protected by copyright. All rights reserved.
July 13, 2017: Chemistry & Biodiversity
https://www.readbyqxmd.com/read/28699201/characterization-of-sugar-and-polyphenolic-diversity-in-floral-nectar-of-different-obla%C3%A4-inska-sour-cherry-clones
#19
Basem Guffa, Nebojša M Nedić, Dragana Č Dabić Zagorac, Tomislav B Tosti, Uroš M Gašić, Maja M Natić, Milica M Fotirić Akšić
'Oblačinska' sour cherry, an autochthonous cultivar, is the most planted cultivar in Serbian orchards. Since fruit trees in temperate zone reward insects by producing nectar which 'quality' affects the efficiency of insect pollination, the aim of this study was analyzing of sugars and polyphenolics in floral nectar of 16 'Oblačinska' sour cherry clones with different yielding potential. The contents of sugars and sugar alcohols were analyzed by ion chromatography, while polyphenolic profile was established using liquid chromatography - mass spectrometry technique (LC/MS)...
July 12, 2017: Chemistry & Biodiversity
https://www.readbyqxmd.com/read/28695711/cuticular-hydrocarbon-profiles-differentiate-tropical-fire-ant-populations-solenopsis-geminata-hymenoptera-formicidae
#20
Lin Hu, Robert K Vander Meer, Sanford D Porter, Li Chen
The cuticular hydrocarbons (CHCs) from hexane rinses of workers from two Florida populations (dark and red forms) of the tropical fire ant, Solenopsis geminata, were separated by silica gel chromatography and identified by GC-MS analysis. Both the dark form and the red form produce similar CHCs with carbon chain lengths ranging from 17 to 35. However, the relative percentages of these CHCs were consistently different between the two color forms. The largest CHC component in the dark form is tricosane, and (Z)-9-tricosene for the red form...
July 11, 2017: Chemistry & Biodiversity
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