journal
MENU ▼
Read by QxMD icon Read
search

Chemistry & Biodiversity

journal
https://www.readbyqxmd.com/read/28094467/chemical-composition-and-biological-activities-of-the-essential-oil-from-leaves-and-flowers-of-pulicaria-incisa-sub-candolleana-growing-in-egypt
#1
Esraa A Shahat, Riham O Bakr, Omayma A Eldahshan, Nahla A Ayoub
The composition of the essential oil isolated from leaves and flowers of Pulicaria incisa sub. candolleana E.Gamal-Eldin was analysed by GC and GC-MS. Forty-nine and sixty-eight compounds were identified from the oils of the leaves and flowers accounting for 86.69% and 84.29%, respectively of the total detected constituents. Both leaves and flowers oils were characterized by the high content of each carvotanacetone with 66.01%, 50.87% and chrysanthenone 13.26%, 24.3% respectively. The cytotoxic activity of both essential oils was evaluated against hepatocellular carcinoma cell line HEPG-2, using MTT assay and vinblastine as a reference drug...
January 17, 2017: Chemistry & Biodiversity
https://www.readbyqxmd.com/read/28092425/chemical-composition-of-the-essential-oil-of-nigeria-grown-hoslundia-opposita-vahl-lamiaceae-dried-leaves-and-its-bioactivity-against-cowpea-seed-bruchid
#2
Samuel Adelani Babarinde, Olufemi Olutoyin Richard Pitan, Ganiyu Olatunji Olatunde, Michael Oluwole Ajala
Due to several ecological and human hazards of synthetic pesticides in postharvest crop protection, there is the need to search for eco-friendly alternatives. In this study, chemical composition and insecticidal activities of essential oil (EO) obtained from Hoslundia opposita dried leaves were evaluated against cowpea seed bruchid. Eight constituents, predominated by oxygenated monoterpenes (78.86%), were identified using GC-MS. The constituents were 1,8-cineole (1; 61.15%), followed by α-terpineol (2; 16...
January 16, 2017: Chemistry & Biodiversity
https://www.readbyqxmd.com/read/28075527/recent-development-of-the-second-and-third-generation-irreversible-egfr-inhibitors
#3
REVIEW
Weiwei Han, Yongli Du
Recent reports suggested that essential directions for new lung cancer, breast carcinoma therapies, as well as the roomier realm of targeted cancer therapies were provided through targeting the epidermal growth factor receptor (EGFR). Patients who carrying non-small cell lung carcinoma (NSCLC) with activating mutations in EGFR initially respond well to the EGFR inhibitors erlotinib and gefitinib, which were located the active site of the EGFR kinase and designed to act as competitive inhibitors of combining with the ATP...
January 11, 2017: Chemistry & Biodiversity
https://www.readbyqxmd.com/read/28054741/antileishmanial-activity-and-immunomodulatory-effects-of-tricin-isolated-from-leaves-of-casearia-arborea-salicaceae
#4
Augusto L Santos, Eduardo S Yamamoto, Luiz Felipe D Passero, Márcia D Laurenti, Ligia F Martins, Marta L Lima, Miriam Uemi, Marisi G Soares, João Henrique G Lago, Andre G Tempone, Patricia Sartorelli
Bioactivity-guided fractionation of antileishmanial active extract from leaves of Casearia arborea led to isolation of three metabolites: tricin (1), 1',6'-di-O-β-D-vanilloyl glucopyranoside (2) and vanillic acid (3). Compound 1 demonstrated the highest activity against the intracellular amastigotes of Leishmania infantum, with an IC50 value of 56 μM. Tricin (1) demonstrated selectivity in mammalian cells (SI > 7) and elicited immunomodulatory effect on host cells. The present work suggests that tricin modulated the respiratory burst of macrophages to a leishmanicidal state, contributing to the parasite elimination...
January 5, 2017: Chemistry & Biodiversity
https://www.readbyqxmd.com/read/28052515/cytotoxic-triterpenoids-from-the-barks-of-betula-platyphylla-var-japonica
#5
Hee Jeong Eom, Hee Rae Kang, Sang Un Choi, Ki Hyun Kim
Phytochemical investigation on the barks of Betula platyphylla var. japonica (Betulaceae) was carried out, resulting in the isolation and identification of three new triterpenoids, 27-O-cis-caffeoylcylicodiscic acid (1), 27-O-cis-feruloylcylicodiscic acid (2), and 27-O-cis-caffeoylmyricerol (3), along with six known triterpenoids, obtusilinin (4), winchic acid (5), 27-O-trans-caffeoylcylicodiscic acid (6), uncarinic acid E (7), myriceric acid B (8), and 3-O-caffeoyloleanolic acid (9). The structures of the new compounds were elucidated by extensive spectroscopic methods, including 1D, 2D NMR, and HR-ESI-MS...
January 4, 2017: Chemistry & Biodiversity
https://www.readbyqxmd.com/read/28036133/chemical-composition-and-biological-prospects-of-essential-oils-and-extracts-of-aphyllocladus-spartioides-growing-in-northwest-argentina
#6
Liliana Celaya, Carmen Viturro, Luís Silva
Aphyllocladus spartioides Weddell is a native and aromatic herb used in traditional medicine, however it is still poorly investigated. In this work, the volatile profile of A. spartioides growing in Hornillos-Northwest Argentina was determined by GC-MS/FID and the phenolic compounds of hydroethanolic and decoction extracts were analyzed by HPLC-DAD. The antibacterial potential, antioxidant activity and α-glucosidase inhibition activity were checked by in vitro assays. The volatile profile allowed the identification of 68 compounds, being α-pinene and cadinene the main ones...
December 30, 2016: Chemistry & Biodiversity
https://www.readbyqxmd.com/read/28036129/synthesis-and-in-vitro-bioactivity-evaluation-of-new-galactose-and-fructose-ester-derivatives-of-5-aminosalicylic-acid
#7
Samira Yousefi, Saadi Bayat, Mohd Basyaruddin Abdul Rahman, Zalikha Ibrahim, Emilia Abdulmalek
Inflammatory bowel disease (IBD) is the main risk factor for developing colorectal cancer which is common in patients of all ages. 5-aminosalicylic acid (5-ASA), structurally related to the salicylates, is highly active in the treatment of IBD with minor side effects. In this study, the synthesis of galactose and fructose esters of 5-ASA was planned to evaluate the role of glycoconjugation on the bioactivity of the parent drug. The antibacterial activity of the new compounds were evaluated against two Gram-negative and two Gram-positive species of bacteria, with a notable effect observed against Staphylococcus aureus and Escherichia coli in comparisons with the 5-ASA...
December 30, 2016: Chemistry & Biodiversity
https://www.readbyqxmd.com/read/28029227/physicochemical-antioxidant-and-cytotoxic-properties-of-xao-tam-phan-paramignya-trimera-root-extract-and-its-fractions
#8
Nguyen Van Tang, Jennette A Sakoff, Christopher J Scarlett
Xao tam phan (Paramignya trimera (Oliv.) Guillaum) has been used as a medicinal plant for cancer prevention and treatment in recent years. The objective of this study was to determine the physicochemical, antioxidant and cytotoxic properties of crude P. trimera root (PTR) extract and its fractions using methanol as a solvent and microwave-assisted extraction as an advanced technique for preparation of the PTR extract. The results showed that the PTR extract had high contents of saponins, phenolics, flavonoids and proanthocyanidins (7731...
December 28, 2016: Chemistry & Biodiversity
https://www.readbyqxmd.com/read/28028933/yield-composition-and-antioxidant-capacity-of-the-essential-oil-of-sweet-basil-and-holy-basil-as-influenced-by-distillation-methods
#9
Santosh Shiwakoti, Osama Saleh, Shital Poudyal, Abdulssamad Barka, Yanping Qian, Valtcho D Zheljazkov
The profile and bioactivity of essential oil (EO) depends on genetic, environmental, and other factors. We hypothesized that the basil EO may be influenced by the distillation methods. Hence, a study was conducted to evaluate the effect of steam distillation (SD) and hydrodistillation (HD) extraction method on the yield, composition, and bioactivity of EO of sweet basil (Ocimum basilicum) and holy basil (Ocimum tenuiflorum). In both basil species, the EO yield (content) was significantly higher from SD than from HD...
December 28, 2016: Chemistry & Biodiversity
https://www.readbyqxmd.com/read/28027618/differential-accumulation-of-volatile-organic-compounds-vocs-by-leaves-and-roots-of-two-guianese-philodendron-species-p-fragrantissimum-kunth-and-p-melinonii-brongn
#10
Nina Joffard, Laurent Legendre, Marc Gibernau, Laurence Pascal
Leaf and root essential oils of two closely related but ecologically distant Philodendron species were extracted in natural conditions in French Guyana and analysed by GC-MS to (i) describe the blends of Volatile Organic Compounds produced by those species and (ii) analyse species and environment-based variations in extracts composition. A total of 135 VOCs were detected with a majority of aliphatic sesquiterpenes. Philodendron fragrantissimum produced mainly β-bisabolene (on average 29.12% of the extract) as well as α- and β-selinene (14...
December 27, 2016: Chemistry & Biodiversity
https://www.readbyqxmd.com/read/28027605/species-specificity-of-aldehyde-and-fatty-acid-profiles-of-four-family-group-representatives-within-the-insect-infraorder-pentatomomorpha-hemiptera-heteroptera
#11
Aleš Tomčala, Anna Jirošová, Petr Žáček, Markéta Kaušková, Oldřich Hovorka, Bohumír Koutek
Reactive α,β-unsaturated aldehydes, including 4-oxo-2-alkenals, are known to be present in volatile secretions of numerous heteropteran insect species. Because the aldehydes are likely to originate from metabolism of fatty acids, the present study aimed to examine and compare the aldehyde and fatty acid profiles of four model heteropteran species. The model species consisted of adult family group representatives within the infraorder Pentatomomorpha (Hemiptera: Heteroptera): seed bug (Lygaeus equestris [Lygaeoidea]), dock leaf bug (Coreus marginatus [Coreoidea]), red firebug (Pyrrhocoris apterus [Pyrrhocoroidea]), and European stink bug (Graphosoma lineatum [Pentatomoidea])...
December 27, 2016: Chemistry & Biodiversity
https://www.readbyqxmd.com/read/28027428/pinecone-of-pinus-koraiensis-inducing-apoptosis-in-human-lung-cancer-cells-by-activating-caspase-3-and-its-chemical-constituents
#12
Tae Kyoung Lee, Hyun-Soo Roh, Jae Sik Yu, Jiwon Baek, Seul Lee, Moonjin Ra, Sun Young Kim, Kwan-Hyuck Baek, Ki Hyun Kim
Pinecones from Pinus koraiensis Siebold & Zucc. (Pinaceae), which have historically been treated as an undesired waste by-product in the processing of seeds, have recently been shown to contain ingredients with potent biological activities, such as polyphenols exhibiting anti-tumor activity. With this study, we seek to broaden our understanding of anti-tumor compounds contained in these pinecones beyond just polyphenols. We found that the water extract of P. koraiensis pinecones exhibits significant anti-cancer activity, with IC50 values ranging from 0...
December 27, 2016: Chemistry & Biodiversity
https://www.readbyqxmd.com/read/28002645/biologically-active-heterocyclic-hybrids-based-on-quinazolinone-benzofuran-and-imidazolium-moieties-synthesis-characterization-cytotoxic-and-antibacterial-evaluation
#13
Parvin Asadi, Ghadamali Khodarahmi, Ali Jahanian-Najafabadi, Lotfollah Saghaie, Farshid Hassanzadeh
Cytotoxic and antimicrobial agents structurally based on quinazolinone, benzofuran and imidazole pharmacophores, have been designed and synthesized. Spectral (IR, (1) H NMR) and elemental analysis data established the structures of these novel 1-[[(1-(benzofuran-2-yl)-2-(quinazolin-4(3H)-one-3-yl)]ethyl-1-yl]-3- methyl imidazol-1-ium chloride hybrid derivatives. All the synthesized compounds were evaluated for in vitro cytotoxicity and antimicrobial activities. Cytotoxic evaluation using MTT assay revealed that compounds 12c, 12g and 12i exhibited significant cytotoxicity with IC50 values 1, 1, 0...
December 21, 2016: Chemistry & Biodiversity
https://www.readbyqxmd.com/read/27997755/chemical-traits-of-hemiparasitism-in-odontites-luteus
#14
Alessandro Venditti, Claudio Frezza, Sebastiano Foddai, Mauro Serafini, Marcello Nicoletti, Armandodoriano Bianco
The study of the monoterpene glycosides content of Odontites luteus has shown the presence of a total of fifteen iridoid glucosides. The presence of compounds (1-5) and (7-10) is perfectly on-line with both the biogenetic pathway for iridoids biosynthesis in Lamiales and the current botanical classification of the species. On the other side, the presence of compounds like agnuside (6), adoxosidic acid (11), monotropein (12), 6,7-dihydromonotropein (13), methyl oleoside (14) and methyl gluco-oleoside (15) is of high interest because, first of all, they have never been reported before in Lamiales...
December 20, 2016: Chemistry & Biodiversity
https://www.readbyqxmd.com/read/27982523/two-new-ergosterol-derivatives-from-the-basidiomycete-cortinarius-glaucopus
#15
Hnin Thanda Aung, Alessio Porta, Marco Clericuzio, Yoshiaki Takaya, Giovanni Vidari
Two new (1, 2) and five (3-7) known sterols were isolated for the first time from the fruiting bodies of Cortinarius glaucopus. Their structures were established by 1- and 2D-NMR spectra and HR-FABS-MS. The relative configuration of 1 was firmly determined by comparison of the observed (1) H-(1) H couplings and NOESY correlations, with those predicted for the computed geometries of the conformers. Calculations were performed by means of DFT with the B3LYP functional at 6-31+G(d,p) level of theory, in CHCl3 as the solvent...
December 16, 2016: Chemistry & Biodiversity
https://www.readbyqxmd.com/read/27982513/a-new-iridoid-dimer-and-other-constituents-from-the-traditional-kurdish-plant-pterocephalus-nestorianus-nab
#16
Fuad O Abdullah, Faiq H S Hussain, Marco Clericuzio, Alessio Porta, Giovanni Vidari
Accompanied by other rare compounds, a new iridoid dimer, named kurdnestorianoside (1), showing an unprecedented secologanol stereochemistry, has been isolated for the first time from the Kurdish medicinal plant Pterocephalus nestorianus, which is used in Kurdistan for treating oral diseases and inflammation. The structure of 1 was established from 1D and 2D NMR spectroscopic data. Kaempferol 3-O-(3'',6''-di-O-E-p-coumaroyl) β-D-glucopyranoside (7) showed a remarkable antiproliferative activity against several human tumor cell lines...
December 16, 2016: Chemistry & Biodiversity
https://www.readbyqxmd.com/read/27981801/natural-products-among-brown-algae-the-case-of-cystoseira-schiffneri-hamel-sargassaceae-phaeophyceae
#17
Abdelkader Ben Salem, Graziano Di Giuseppe, Andrea Anesi, Saoussen Hammami, Zine Mighri, Graziano Guella
A chemotaxonomic study on the marine brown alga Cystoseira schiffneri collected from the Tunisian marine coast allowed us to identify kjellmanianone (1) and a new isololiolide derivative named schiffnerilolide (2). The structure elucidation and the assignment of relative configurations of the isolated natural products were based on advanced mass spectrometric and nuclear magnetic resonance techniques. This outcome suggested a close phylogenetic relationship of Cystoseira schiffneri with brown algae belonging to genus Sargassum C...
December 16, 2016: Chemistry & Biodiversity
https://www.readbyqxmd.com/read/27981800/identification-of-glucosinolates-in-seeds-of-three-brassicaceae-species-known-to-hyperaccumulate-heavy-metals
#18
Sabine Montaut, Benjamin S Guido, Claude Grison, Patrick Rollin
Plants from the Brassicaceae family are known to contain secondary metabolites called glucosinolates. Our goal was to establish by LC-MS the glucosinolate profile of seeds of three Brassicaceae species known to hyperaccumulate heavy metals. We investigated Alyssum fallacinum auct. non Hausskn., Iberis intermedia Guers., and Noccaea caerulescens (J. Presl & C. Presl) F.K. Mey. Our results indicate that A. fallacinum seeds contain glucoiberin and glucoibervirin, which had not been previously identified in this plant...
December 16, 2016: Chemistry & Biodiversity
https://www.readbyqxmd.com/read/27981797/laserpitium-zernyi-hayek-flower-and-herb-extracts-phenolic-compounds-and-anti-edematous-antioxidant-and-antimicrobial-activities
#19
Višnja B Popović, Maja A Tomić, Radica M Stepanović-Petrović, Ana M Micov, Marina T Milenković, Silvana D Petrović, Ljuboš J Ušjak, Marjan S Niketić
Phenolic compounds and different biological activities of the dry methanol extracts of the flowers and the herb (aerial parts without flowers) of Laserpitium zernyi Hayek (Apiaceae) were investigated. The total phenolic contents in the extracts were determined spectrophotometrically using Folin-Ciocalteu reagent. In both extracts, apigenin, luteolin, their 7-O-glucosides and chlorogenic acid were detected by HPLC. Identified phenolics were quantified in both extracts, except luteolin in L. zernyi herb extract...
December 16, 2016: Chemistry & Biodiversity
https://www.readbyqxmd.com/read/27981754/identification-of-predominant-phytochemical-compounds-and-cytotoxic-activity-of-wild-olive-leaves-olea-europaea-l-ssp-sylvestris-harvested-in-south-portugal
#20
Justyna Makowska-Wąs, Agnieszka Galanty, Joanna Gdula-Argasińska, Małgorzata Tyszka-Czochara, Agnieszka Szewczyk, Ricardo Nunes, Isabel de Carvalho, Marta Michalik, Paweł Paśko
This study has been aimed at providing a qualitative and quantitative evaluation of selected phytochemicals such as phenolic acids, flavonoids, oleuropein, fatty acids profile, and volatile oil compounds, present in wild olive leaves harvested in Portugal, as well as at determining their antioxidant and cytotoxic potential against human melanoma HTB-140 and WM793, prostate cancer DU-145 and PC-3, hepatocellular carcinoma Hep G2 cell lines, as well as normal human skin fibroblasts BJ and prostate epithelial cells PNT2...
December 16, 2016: Chemistry & Biodiversity
journal
journal
40579
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"