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Chemistry & Biodiversity

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https://www.readbyqxmd.com/read/28337842/halogenated-briarane-diterpenes-with-acetyl-migration-from-the-gorgonian-coral-junceella-fragilis
#1
Wei Cheng, Xiaodan Li, Fuling Yin, Leen van Ofwegen, Wenhan Lin
Chemical examination of the gorgonian coral Junceella fragilis resulted in the isolation of four pairs of acetyl isomers belonging to briarane diterpenoids, including five new compounds. Their structures were determined on the basis of extensive spectroscopic (IR, MS, NMR and single-crystal X-ray diffraction) analysis in association with the chemical conversion. Each pair of isomers featured by dynamical interconversion through as acetyl migration in 1,2-diol, which was postulated to be generated under the formation of a cyclic orthoacetate intermediate...
March 24, 2017: Chemistry & Biodiversity
https://www.readbyqxmd.com/read/28332769/oleanane-type-saponins-from-glochidion-hirsutum-and-their-cytotoxic-activities
#2
Nguyen Van Thang, Vu Kim Thu, Nguyen Xuan Nhiem, Duong Thi Dung, Tran Hong Quang, Bui Huu Tai, Hoang Le Tuan Anh, Pham Hai Yen, Nguyen Thi Thanh Ngan, Nguyen Huy Hoang, Phan Van Kiem
Five new oleanane-type saponins, hirsutosides A-E, were isolated from the leaves of Glochidion hirsutum (Roxb.) Voigt. Their structures were elucidated as 21β-benzoyloxy-3β,16β,23,28-tetrahydroxyolean-12-ene 3-O-β-D-glucopyranoside (1), 21β-benzoyloxy-3β,16β,23,28-tetrahydroxyolean-12-ene 3-O-β-D-glucopyranosyl-(1→3)-β-D-glucopyranoside (2), 21β-benzoyloxy-3β,16β,23,28-tetrahydroxyolean-12-ene 3-O-6-acetyl-[β-D-glucopyranosyl-(1→3)]-β-D-glucopyranoside (3), 21β-benzoyloxy-3β,16β,23,28-tetrahydroxyolean-12-ene 3-O-β-D-glucopyranosyl-(1→3)-α-L-arabinopyranoside (4), and 21β-benzoyloxy-3β,16β,23-trihydroxyolean-12-ene-28-al 3-O-β-D-glucopyranosyl-(1→3)-α-L-arabinopyranoside (5)...
March 23, 2017: Chemistry & Biodiversity
https://www.readbyqxmd.com/read/28332760/cytotoxic-essential-oils-from-eryngium-campestre-and-eryngium-amethystinum-apiaceae-growing-in-central-italy
#3
Kevin Cianfaglione, Evy E Blomme, Luana Quassinti, Massimo Bramucci, Giulio Lupidi, Stefano Dall'Acqua, Filippo Maggi
Eryngium campestre and E. amethystinum are thorny herbs belonging to the Apiaceae family and spontaneously growing in stony pastures and dry meadows, preferentially on calcareous substrates. In the Mediterranean countries, these plants have been used as a food or traditional remedies to treat various ailments. In the present work, we have analysed the chemical composition of the essential oils distilled from the aerial parts by GC-FID and GC-MS, and evaluated their cytotoxic effects on a panel of human cancer cells, namely A375 (human malignant melanoma), MDA-MB 231 cells (human breast adenocarcinoma) and HCT116 cells (human colon carcinoma), by the MTT assay...
March 23, 2017: Chemistry & Biodiversity
https://www.readbyqxmd.com/read/28323398/chemical-components-from-phaeanthus-vietnamensis-and-their-inhibitory-no-production-in-bv2-cells
#4
Nguyen Xuan Nhiem, Nguyen Trung Tuong, Pham Thanh Ky, Lalita Subedi, SeonJu Park, Tran Minh Ngoc, Pham Hai Yen, Bui Huu Tai, Tran Hong Quang, Phan Van Kiem, Sun Yeou Kim, Seung Hyun Kim
Phaeanthus vietnamensis Ban is a well-known medicinal plant which has been used for the treatment of various inflammatory diseases in traditional medicine. Using various chromatographic methods, three new compounds, (7S,8R,8'R)-3,5,3',5'-tetramethoxy-9,9'-epoxylignan-4,4',7-triol (1), 8α-hydroxyoplop-11(12)-en-14-one (5), and (1R,2S,4S)-2-E-cinnamoyloxy-4-acetyl-1-methylcyclohexan-1-ol (12) along with twelve known compounds were isolated from the leaves of P. vietnamensis. Their chemical structures were elucidated by physical and chemical methods...
March 21, 2017: Chemistry & Biodiversity
https://www.readbyqxmd.com/read/28323385/six-new-acylphloroglucinols-from-dryopteris-championii
#5
Neng-Hua Chen, Yi-Rui Qian, Wen Li, Yu-Bo Zhang, Yi-Duo Zhou, Guo-Qiang Li, Yao-Lan Li, Guo-Cai Wang
Six new acylphloroglucinols (1-6) were isolated from Dryopteris championii. Their structures were established on the basis of extensive analysis of spectroscopic data and comparison with reported data. The antibacterial activities of the isolates were evaluated against Staphylococcus aureus, Escherichia coli, Bacillus subtilis and Dickeya zeae. This article is protected by copyright. All rights reserved.
March 21, 2017: Chemistry & Biodiversity
https://www.readbyqxmd.com/read/28323380/sarcophytrols-g-l-novel-minor-metabolic-components-from-south-china-sea-soft-coral-sarcophyton-trocheliophorum-marenzeller
#6
Lin-Fu Liang, Wen-Ting Chen, Ernesto Mollo, Li-Gong Yao, He-Yao Wang, Wei Xiao, Yue-Wei Guo
Minor metabolic components, six new cembranoids sarcophytrols G - L (1 - 6) along with two known related analogues 7 and 8, were isolated from the South China Sea soft coral Sarcophyton trocheliophorum. Their structures were elucidated by extensive spectroscopic analyses (1D- and 2D-NMR, and ESI-MS.) as well as comparison with literature data. As part of our ongoing research project for discovering bioactive substances from Chinese marine invertebrates, compounds 1 - 8 were tested for their inhibitory activity against protein tyrosine phosphatase 1B (PTP1B), a key target for the treatment of Type-II diabetes and obesity...
March 21, 2017: Chemistry & Biodiversity
https://www.readbyqxmd.com/read/28317320/differential-in-vitro-antitumor-activity-of-essential-oil-of-lippia-citriodora-from-different-regions-in-morocco
#7
Moulay Ali Oukerrou, Mounir Tilaoui, Hassan Ait Mouse, Najat Bouchmaa, Abdelmajid Zyad
The aim of this work was to investigate the in vitro anticancer effect of the essential oil of dried leaves of Lippia citriodora (H.B. & K.) harvested in different regions of Morocco. This effect was evaluated against the P815 murine mastocytoma cell line using the MTT assay. Interestingly, this work demonstrated for the first time that these essential oils exhibited a strong cytotoxic activity against the P815 cell line, with IC50 values ranging from 7.75 μg/ml to 13.25 μg/ml. This cytotoxicity began early and increased in a dose and time dependent manner...
March 19, 2017: Chemistry & Biodiversity
https://www.readbyqxmd.com/read/28306206/phytochemical-profile-and-biological-activities-of-helianthemum-canum-from-turkey
#8
Ayşe Baldemir, Neslihan Gökşen, Nilay Ildız, Gökçe Şeker Karatoprak, Müberra Koşar
In the current study, antioxidant, antibacterial activities, and the phenolic compositions of extracts from Helianthemum canum L. Baumg (Apiaceae) aerial parts were investigated for the first time. The H. canum was extracted with 70% methanol (HCMeOH) and water (HCW). Both extracts were determined by total phenolic contents (3 mg/mL), flavonoids (1.5 mg/mL), flavonols (1.5 mg/mL), qualitative-quantitative compositions, iron (II) chelation activities (0.1-5 mg/mL), free radical scavenging activities (DPPH(●) : 0...
March 17, 2017: Chemistry & Biodiversity
https://www.readbyqxmd.com/read/28306205/chemical-composition-and-antibacterial-activity-of-iranian-lavandula-x-hybrida
#9
Iman Bajalan, Razieh Rouzbahani, Abdollah Ghasemi Pirbalouti, Filippo Maggi
Lavandin (Lavandula x hybrida) is an evergreen shrub and cultivated worldwide for its essential oil which possesses various biological activities. In this study, the essential oils were isolated from the leaves of ten lavandin populations in western Iran. The hydrodistilled essential oils were analyzed by GC-FID/MS. Results indicated significant differences (p ≤0.05) among the various populations for the main essential oil constituents. The major components from different populations were 1,8-cineole (31...
March 17, 2017: Chemistry & Biodiversity
https://www.readbyqxmd.com/read/28299905/variation-in-phenolic-profile-%C3%AE-carotene-and-flavonoid-contents-biological-activities-of-two-tagetes-species-from-pakistani-flora
#10
Muhammad Adnan Ayub, Abdullah Ijaz Hussain, Muhammad Asif Hanif, Shahzad Ali Shahid Chatha, Ghulam Mustafa Kamal, Muhammad Shahid, Omar Janneh
The objective of present study was to evaluate the variation in phenolic profile, β-carotene, flavonoid contents, antioxidant and antimicrobial properties of Tagetes eracta and Tagetes patula (T. erecta and T. patula) through different in vitro assays.,Antioxidant activity was determined through 2, 2-diphenyl-1-picrylhydrazyl (DPPH) free radical scavenging and inhibition of linoleic acid peroxidation assays and antibacterial and antifungal activities studied using the disc diffusion and resazurin microtiter-plate assays against bacterial and fungal strains...
March 16, 2017: Chemistry & Biodiversity
https://www.readbyqxmd.com/read/28299876/essential-oils-of-myrtaceae-species-growing-wild-in-tunisia-chemical-variability-and-antifungal-activity-against-biscogniauxia-mediterranea-the-causative-agent-of-charcoal-canker
#11
Islem Yangui, Meriem Zouaoui Boutiti, Mohamed Boussaid, Chokri Messaoud
The chemical composition of five Eucalyptus species and five Myrtus communis L. populations was investigated using GC-MS and GC-FID. For Eucalyptus essential oils, 32 compounds, representing 88.56-96.83% of the total oil according to species, were identified. The main compounds were 1,8-cineole, α-pinene, p-cymene, ɤ-gurjunene, α-aromadendrene and β-phellandrene. For Myrtle essential oils, 26 compounds, representing 93.13-98.91% of the total oil were identified. α-pinene, 1,8-cineole, linalool and myrtenyl acetate were found to be the major compounds...
March 16, 2017: Chemistry & Biodiversity
https://www.readbyqxmd.com/read/28296214/morphological-secondary-metabolite-and-its-rdna-variability-within-usnic-acid-containing-lichen-thalli-of-the-genus-xanthoparmelia-explored-at-the-local-scale-of-rock-outcrop-in-western-italian-alps
#12
Enrica Matteucci, Andrea Occhipinti, Rosanna Piervittori, Massimo E Maffei, Sergio E Favero-Longo
Lichen secondary metabolites (LSMs) are regarded with interest for valuable biological properties, but chemical variability among/within lichen taxa has been only fragmentarily characterized by advanced analytical techniques. Knowledge of variability at a local geographic scale has been particularly neglected, while it should address the collection of chemically homogeneous materials to test and exploit LSMs. Here we evaluated the chemical variability of 48 Xanthoparmelia specimens from two rock outcrops in Western Italian Alps, representative of nine morphotypes and sixteen rDNA ITS haplotypes...
March 11, 2017: Chemistry & Biodiversity
https://www.readbyqxmd.com/read/28296180/antioxidant-capacity-phenolic-constituents-and-toxicity-of-hot-water-extract-from-red-maple-buds
#13
Naamwin R Meda, Patrice E Poubelle, Tatjana Stevanovic
The present study reports, for the first time, the results of the antioxidant capacity and the phenolic composition of a hot water extract from red maple buds (RMB), as well as its safety. In this regard and comparatively to antioxidant standards, this extract exhibits a significant antiradical capacity when tested by 2,2-diphenyl-1-picrylhydrazyl (DPPH•) and anion superoxide trapping assays. High-resolution mass spectrometric (HRMS) and Nuclear Magnetic Resonance (NMR) analyses permitted to determine for the first time, in red maple species, cyanidin-3-O-glucoside, quercetin-3-O-galactoside, quercetin-3-O-arabinoside and quercetin...
March 11, 2017: Chemistry & Biodiversity
https://www.readbyqxmd.com/read/28294523/flavonoids-from-potentilla-parvifolia-fisch-and-their-neuroprotective-effects-in-human-neuroblastoma-sh-sy5y-cells-in-vitro
#14
Zhenzhen Yuan, Guangxiang Luan, Zhenhua Wang, Xueyan Hao, Ji Li, Yourui Suo, Gang Li, Honglun Wang
Potentilla parvifolia Fisch. (Rosaceae) is a traditional medicinal plant in China. In this study, seven flavonoids, ayanin (1), tricin (2), quercetin (3), tiliroside (4), miquelianin (5), isoquercitrin (6), and astragalin (7), were separated and purified from ethanol extractive fractions from ethanol extracts of P. parvifolia using a combination of sevaral chromatographic methods. The human neuroblastoma SH-SY5Y cells were differentiated with all trans-retinoic acid and treated with okadaic acid to induce tau protein phosphorylation and synaptic atrophy, which could establish an Alzheimer's disease cell model...
March 11, 2017: Chemistry & Biodiversity
https://www.readbyqxmd.com/read/28281331/new-coumarinyl-ethers-in-daphne-oleoides-schreb-collected-from-sardinia-island
#15
Alessandro Venditti, Cinzia Sanna, Lorenzo M Lorenzetti, Mauro Ballero, Armandodoriano Bianco
The phytochemical analysis of the ethanolic extract obtained from D. oleoides collected from Sardinia Island allowed the isolation of several new constituents for the species (3, 8 and 9) together with two new coumarinyl ethers (1 and 2) besides the chemotaxonomic markers of the Daphne genus (4 - 7 and 10) which are also known to possess interesting biological activities. The structure of the new compounds were elucidated by extensive spectroscopic and spectrometric analyses. The identification of these compounds gives an experimental evidence of the variability in the secondary metabolites pattern owned by populations growing in restricted area in respect to populations not confined by geographical barrier...
March 9, 2017: Chemistry & Biodiversity
https://www.readbyqxmd.com/read/28281324/accumulation-of-flavonoid-glycosides-and-ufgt-gene-expression-in-mulberry-leaves-morus-alba-l-before-and-after-frost
#16
Xiaofeng Yu, Yiling Zhu, Jingyi Fan, Dujun Wang, Xiaohui Gong, Zhen Ouyang
In order to determine the molecular mechanism underlying the influence of frost on chemical changes in mulberry leaves, the UFGT activity, expression level and accumulation of flavonoid glycosides in mulberry leaves (Morus alba L.) were studied. The expression of UFGT gene was investigated by quantitative real-time PCR (qRT-PCR) and the UFGT activity, accumulation of flavonoid glycosides were studied by high performance liquid chromatography. Then the correlation between the expression level of UFGT, the UFGT activity and the flavonoid glycosides accumulation, temperature was explored...
March 9, 2017: Chemistry & Biodiversity
https://www.readbyqxmd.com/read/28281322/chemical-composition-antibacterial-antibiofilm-and-synergistic-properties-of-essential-oils-from-eucalyptus-globulus-labill-and-seven-mediterranean-aromatic-plants
#17
Maria Vieira, Lucinda J Bessa, M Rosário Martins, Sílvia Arantes, António P S Teixeira, Ângelo Mendes, Paulo Martins da Costa, Anabela D F Belo
Essential oils (EOs) from Eucalyptus globulus Labill. ssp. globulus and from Mediterranean autochthonous aromatic plants - Thymus mastichina L., Mentha pulegium L., Rosmarinus officinalis L., Calamintha nepeta (L.) Savi ssp. nepeta, Cistus ladanifer L., Foeniculum vulgare L., Dittrichia viscosa (L.) Greuter ssp. viscosa - were extracted by hydrodistillation and characterized by GC-FID and NMR spectroscopy. EOs were evaluated for antimicrobial properties against several bacterial strains, using diverse methods, namely, the agar disc-diffusion method, the microdilution method, the crystal violet assay and the Live/Dead staining for assessment of biofilm formation...
March 9, 2017: Chemistry & Biodiversity
https://www.readbyqxmd.com/read/28281314/a-new-4-methoxy-1-5-dihydroxyisoquinoline-from-scolopendra-subspinipes-mutilans
#18
Y-R Guo, P-X Wu, H-M Xu, W-Y Qi
A new isoquinoline, 4-methoxy-1,5-dihydroxyisoquinoline (1), was obtained from Scolopendra subspinipes mutilans. Compound 1 showed moderate cytotoxicity on tumour cells with IC50 values ranging from 13-26 μM against five Esophageal Squamous Cancer Cells (ESCC) whereas low cytotoxicity against normal Human Esophageal Epithelial Cells (HEEC). Isoquinoline ring oxidized by C-1, C-4, and C-5 can enhance its cytotoxicity. In addition, compound 1 showed potent inhibitory effect (inhibition rate >50% at 13 μM) on cell migration in Human Umbilical Vein Endothelial Cells (HUVEC)...
March 9, 2017: Chemistry & Biodiversity
https://www.readbyqxmd.com/read/28273408/profiling-of-compositions-of-essential-oils-and-volatiles-of-salvia-limbata-using-traditional-and-advanced-techniques-and-evaluation-for-biological-activities-of-their-extracts
#19
Majid Mohammadhosseini, Abolfazl Akbarzadeh, Guido Flamini
In the present work, the essential oils and volatiles from flowers, leaves and stems of Salvia limbata obtained using microwave assisted hydrodistillation (MAHD), solvent free microwave extraction (SFME), headspace assisted analysis (HSA) and headspace solid phase microextraction (HS-SPME) have been characterized for the first time. The results have been also compared with those from traditional separation techniques involving hydrodistillation (HD) and steam distillation (SD). Regardless of some common compounds in all of the profiles, some dissimilarities were noted due to the use of different extracting approaches...
March 8, 2017: Chemistry & Biodiversity
https://www.readbyqxmd.com/read/28273402/insecticidal-activity-of-the-leaf-essential-oil-of-peperomia-borbonensis-miq-piperaceae-and-its-major-components-against-the-melon-fly-bactrocera-cucurbitae-diptera-tephritidae
#20
Emmanuelle Dorla, Anne Bialecki, Zoé Deuscher, Agathe Allibert, Isabelle Grondin, Jean-Philippe Deguine, Philippe Laurent
The essential oil from leaves of Peperomia borbonensis from Réunion Island was obtained by hydrodistillation and characterized using GC-FID, GC-MS and NMR. The main components were myristicin (39.5%) and elemicin (26.6%). The essential oil (EO) of Peperomia borbonensis and its major compounds (myristicin and elemicin), pure or in a mixture, were evaluated for their insecticidal activity against Bactrocera cucurbitae (Diptera: Tephritidae) using a filter paper impregnated bioassay. The concentrations necessary to kill 50% (LC50 ) and 90% (LC90 ) of the flies in three hours were determined...
March 8, 2017: Chemistry & Biodiversity
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