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Chemistry & Biodiversity

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https://www.readbyqxmd.com/read/28444991/new-hydrazides-and-hydrazide-hydrazones-of-2-3-dihalogen-substituted-propionic-acids-synthesis-and-in-vitro-antimicrobial-activity-evaluation
#1
Łukasz Popiołek, Anna Biernasiuk
The main aim of this research was the synthesis, spectral identification and in vitro antimicrobial evaluation of new hydrazides and hydrazide-hydrazones of 2,3-dihalogen substituted propionic acids. New hydrazides were obtained by the substitution reaction of appropriate ethyl esters of 2,3-dihalogen substituted propionic acids with hydrazine hydrate. Then obtained hydrazides were subjected to condensation reaction with various aldehydes which yielded with new hydrazide-hydrazone derivatives. All obtained compounds were identified on the basis of spectral methods ((1) H NMR, (13) C NMR) and in vitro screened against a panel of bacterial and fungal strains according to EUCAST and CLSI guidelines...
April 26, 2017: Chemistry & Biodiversity
https://www.readbyqxmd.com/read/28434194/cytotoxic-triterpenoids-from-the-stalks-of-microtropis-triflora
#2
Xiao-Wei Zhang, Kui-Wu Wang, Man-Qing Zhou
Bioassay-guided phytochemcal investigation of the stalks of Microtropis triflora Merr. et Freem led to the isolation of ten triterpenes 1-10, including one novel compound 24-epoxy-2α, 24-dihydroxy-29-friedelanoic acid (1). Their chemical structures were identified on the basis of spectroscopic analysis, including HRESI mass spectrometry, 1D and 2D NMR ((1) H, (13) C, (1) H-(1) H COSY, HSQC, HMBC and NOESY), and by comparison with the data reported. The cytotoxicities of the compounds 1-10 against a panel of cultured human tumor cell lines (Bcap37, SMMC7721, Hela, CNE) were evaluated...
April 23, 2017: Chemistry & Biodiversity
https://www.readbyqxmd.com/read/28425165/melanogenesis-inhibitory-and-cytotoxic-activities-of-limonoids-alkaloids-and-phenolic-compounds-from-phellodendron-amurense-bark
#3
Toshihiro Akihisa, Satoru Yokokawa, Eri Ogihara, Masahiro Matsumoto, Jie Zhang, Takashi Kikuchi, Kazuo Koike, Masahiko Abe
Four limonoids, 1-4, five alkaloids, 5-9, and four phenolic compounds, 10-13, were isolated from a MeOH extract of the bark of Phellodendron amurense (Rutaceae). Among these, compound 13 was a new, and its structure was established as rel-(1R,2R,3R)-5-hydroxy-3-(4-hydroxy-3-methoxyphenyl)-6-methoxy-1-(methoxycarbonylmethyl)indane-2-carboxylic acid methyl ester (γ-di(methyl ferulate)) based on the spectrometric analysis. Upon evaluation of compounds 1-13 against the melanogenesis in the B16 melanoma cells induced with α-melanocyte-stimulating hormone (α-MSH), four compounds, limonin (1), noroxyhydrastinine (6), haplopine (7), and 4-methoxy-N-methyl-2-quiolone (8), exhibited potent melanogenesis-inhibitory activities with almost no toxicity to the cells...
April 20, 2017: Chemistry & Biodiversity
https://www.readbyqxmd.com/read/28422413/essential-oils-as-biocides-for-the-control-of-fungal-infections-and-devastating-pest-tuta-absoluta-of-tomato-lycopersicon-esculentum-mill
#4
Samira Bouayad Alam, Mohammed El Amine Dib, Nassim Djabou, Boufeldja Tabti, Nassira Guaouar, Jean Costa, Alain Muselli
Thymus capitatus and Tetraclinis articulata essential oils as well their major components (carvacrol and α-pinene) were evaluated for their antifungal and insecticidal activities. Both oils showed good in vitro antifungal activity against Fusarium oxysporum, Aspergillus niger, Penicillium sp, Alternaria alternata and Botrytis cinerea, the fungi causing tomato rot. In vivo results indicate the efficacies of both essential oils and carvacrol of reduce postharvest fungal pathogens, such as B. cinerea and A. alternata that are responsible of black and gray rot of tomato fruit...
April 19, 2017: Chemistry & Biodiversity
https://www.readbyqxmd.com/read/28419767/four-new-diterpene-glucosides-from-perovskia-atriplicifolia
#5
Lu Gao, Jun Zhou, Le-Yu Zhu, Juan-Rong Zhang, Yu-Xing Jing, Jia-Wen Zhao, Xiang-Zhong Huang, Gan-Peng Li, Zhi-Yong Jiang, Da-Yuan Xue
Four new diterpene glucosides, namely perovskiaditerpenosides A-D (1-4), were isolated from the butanol extract of Perovskia atriplicifolia. Their structures were well elucidated by chemical methods and comprehensive spectroscopic analyses including MS, IR, and NMR (1D and 2D). The newly isolated compounds were screened for their cytotoxic activity against HepG2, NB4 Hela, K562, HL60, MCF7 and HL60. The obtained results indicated that the new compounds possessed considerable cytotoxic activity. This article is protected by copyright...
April 17, 2017: Chemistry & Biodiversity
https://www.readbyqxmd.com/read/28398659/hypaphorine-an-indole-alkaloid-isolated-from-caragana-korshinskii-kom-inhibites-3t3-l1-adipocyte-differentiation-and-improves-insulin-sensitivity-in-vitro
#6
Guangxiang Luan, Fangfang Tie, Zhenzhen Yuan, Gang Li, Jie He, Zhenhua Wang, Honglun Wang
Obesity, a major health problem worldwide, is a complex multifactorial chronic disease that increases the risk for insulin resistance, type 2 diabetes, coronary heart disease and hypertension. In this study, we assessed methods to isolate hypaphorine, a potent drug candidate for obesity and insulin resistance. Semi-preparative reversed-phase liquid chromatography (semi-preparative RPLC) was established as a method to separate three compounds, adenosine, L-tryptophan and hypaphorine, from the crude extracts of Caragana korshinskii Kom...
April 11, 2017: Chemistry & Biodiversity
https://www.readbyqxmd.com/read/28398606/variation-in-essential-oil-and-bioactive-compounds-of-curcuma-kwangsiensis-collected-from-natural-habitats
#7
Lanyue Zhang, Zhiwen Yang, Zebin Huang, Mincong Zhao, Penghui Li, Wei Zhou, Kun Zhang, Xi Zheng, Li Lin, Jian Tang, Yanxiong Fang, Zhiyun Du
The chemical compositions of essential oils (EOs) extracted from Curcuma kwangsiensis rhizomes collected from six natural habitats in China were evaluated using gas chromatography-mass spectrometry (GC-MS). Fifty-seven components were identified from the six Eos; their main constituents were 8,9-dehydro-9-formyl-cycloisolongifolene (2.37-42.59%), germacrone (6.53-22.20%), and L-camphor (0.19-6.12%). The six EOs exhibited different DPPH radical-scavenging activities (IC50 , 2.24-31.03 μg/mL), with the activity of most of the EOs being much higher than that of Trolox C (IC50 , 10...
April 11, 2017: Chemistry & Biodiversity
https://www.readbyqxmd.com/read/28390085/four-new-nanaomycins-produced-by-streptomyces-hebeiensis-derived-from-lichen
#8
Chengbin Liu, Yi Jiang, Hui Lei, Xiu Chen, Qingjuan Ma, Li Han, Xueshi Huang
Four new nanaomycins (1-4), together with two known compounds, nanaomycin αA (5) and nanaomycin βA (6) were isolated from a fermentation broth of Streptomyces hebeiensis derived from lichen. The structures of the new nanaomycins 1-4 were established using comprehensive NMR spectroscopic data analysis as well as UV, IR, and MS data. The antimicrobial activities of 1-6 were evaluated against Gram-positive bacteria and fungus. Compounds 5 and 6 showed antimicrobial activities against the test microorganisms, while 1-4 were inactive at 100 μg/mL...
April 8, 2017: Chemistry & Biodiversity
https://www.readbyqxmd.com/read/28388815/anticancer-and-antimicrobial-activity-of-dehydrozingerone-based-cyclopropyl-derivatives
#9
Adrijana Z Burmudžija, Jovana M Muškinja, Marijana M Kosanić, Branislav R Ranković, Slađana B Novaković, Snežana B Đorđević, Tatjana P Stanojković, Dejan D Baskić, Zoran R Ratković
A small series of 1-acetyl-2-(4-alkoxy-3-methoxyphenyl)cyclopropanes was prepared, starting from dehydrozingerone [4-(4-hydroxy-3-methoxyphenyl)-3-buten-2-one] and its O-alkyl derivatives. Their microbiological activities toward some strains of bacteria and fungi were tested, as well as their in vitro cytotoxic activity against some cancer cell lines (HeLa, LS174 and A549). All synthesized compounds showed significant antimicrobial activity and expressed cytotoxic activity against tested carcinoma cell lines, but they showed no significant influence on normal cell line (MRC5)...
April 7, 2017: Chemistry & Biodiversity
https://www.readbyqxmd.com/read/28387012/new-avermectin-analogues-from-a-mutant-streptomyces-avermectinius-strain
#10
Yongjun Zhang, Cheng Zhang, Keke Wang, Guoliang Chen, Peng Sun
Two new avemectin analogues (1 and 2) belonging to "b" series of components were isolated from a ∆aveCDE mutant Streptomyces avermectinius strain. Their structures were elucidated by detailed analysis of NMR and MS spectroscopic data. Compounds 1 and 2 displayed moderate cytotoxicities against B16, MG-63, and Saos-2 cell lines in an in vitro assay. This article is protected by copyright. All rights reserved.
April 7, 2017: Chemistry & Biodiversity
https://www.readbyqxmd.com/read/28374459/new-resorcinol-derivatives-from-a-sponge-derived-fungus-hansfordia-sinuosae
#11
Zehong Wu, Yuan Li, Dong Liu, Min Ma, Jianliang Chen, Wenhan Lin
Ten new resorcinol derivatives named Hansfordiols A-J (1-10) were isolated from the fermentation broth of the sponge-derived fungus Hansfordia sinuosae. High resolution electron ionization mass spectrometry, FT-IR spectroscopy, and NMR techniques were used to elucidate the structures of these compounds, and the absolute configurations were established by the modified Mosher's method and their specific optical rotation. The structures of compounds 8-10 were featured with various chlorination at aromatic rings...
April 4, 2017: Chemistry & Biodiversity
https://www.readbyqxmd.com/read/28374446/superbanone-a-new-2-aryl-3-benzofuranone-and-other-bioactive-constituents-from-the-tube-roots-of-butea-superba
#12
Jutatip Boonsombat, Vilailak Prachyawarakorn, Acharavadee Pansanit, Chulabhorn Mahidol, Somsak Ruchirawat, Sanit Thongnest
Phytochemical investigation from the tube roots of Butea superba, led to the isolation and identification of a new 2-aryl-3-benzofuranone named superbanone (1), one benzoin, 2-hydroxyl-1-(2-hydroxy-4-methoxyphenyl)-2-(4-methoxy-phenyl)ethanone (2), eight pterocarpans (3-10), and eleven isoflavonoids (11-21). Compound 2 was identified for the first time as a natural product. The structure of the isolated compounds was elucidated using spectroscopic methods, mainly 1D and 2D NMR. The isolated compounds and their derivatives were evaluated for α-glucosidase inhibitory and antimalarial activities...
April 4, 2017: Chemistry & Biodiversity
https://www.readbyqxmd.com/read/28371315/new-cytotoxic-alkylated-chalcones-from-fatoua-villosa
#13
Shi-Yun Su, Jing-Jing Xue, Guang-Yu Yang, Chun Lei, Ai-Jun Hou
Three new alkylated chalcones, villosins A-NDASH-C (1 - 3), five known analogues, together with ten known coumarins, were isolated from Fatoua villosa. The structures of the new compounds were elucidated by extensive spectroscopic analysis, including 1D-, 2D-NMR, and MS data. Compounds 1 - 3 showed cytotoxicity against five kinds of human tumor cell lines (NB4, A549, SHSY5Y, PC3 and MCF7) with IC50 values ranging from 1.4±0.1 to 5.7±0.3 μM. This article is protected by copyright. All rights reserved.
March 31, 2017: Chemistry & Biodiversity
https://www.readbyqxmd.com/read/28337842/halogenated-briarane-diterpenes-with-acetyl-migration-from-the-gorgonian-coral-junceella-fragilis
#14
Wei Cheng, Xiaodan Li, Fuling Yin, Leen van Ofwegen, Wenhan Lin
Chemical examination of the gorgonian coral Junceella fragilis resulted in the isolation of four pairs of acetyl isomers belonging to briarane diterpenoids, including five new compounds. Their structures were determined on the basis of extensive spectroscopic (IR, MS, NMR and single-crystal X-ray diffraction) analysis in association with the chemical conversion. Each pair of isomers featured by dynamical interconversion through as acetyl migration in 1,2-diol, which was postulated to be generated under the formation of a cyclic orthoacetate intermediate...
March 24, 2017: Chemistry & Biodiversity
https://www.readbyqxmd.com/read/28332769/oleanane-type-saponins-from-glochidion-hirsutum-and-their-cytotoxic-activities
#15
Nguyen Van Thang, Vu Kim Thu, Nguyen Xuan Nhiem, Duong Thi Dung, Tran Hong Quang, Bui Huu Tai, Hoang Le Tuan Anh, Pham Hai Yen, Nguyen Thi Thanh Ngan, Nguyen Huy Hoang, Phan Van Kiem
Five new oleanane-type saponins, hirsutosides A-E, were isolated from the leaves of Glochidion hirsutum (Roxb.) Voigt. Their structures were elucidated as 21β-benzoyloxy-3β,16β,23,28-tetrahydroxyolean-12-ene 3-O-β-D-glucopyranoside (1), 21β-benzoyloxy-3β,16β,23,28-tetrahydroxyolean-12-ene 3-O-β-D-glucopyranosyl-(1→3)-β-D-glucopyranoside (2), 21β-benzoyloxy-3β,16β,23,28-tetrahydroxyolean-12-ene 3-O-6-acetyl-[β-D-glucopyranosyl-(1→3)]-β-D-glucopyranoside (3), 21β-benzoyloxy-3β,16β,23,28-tetrahydroxyolean-12-ene 3-O-β-D-glucopyranosyl-(1→3)-α-L-arabinopyranoside (4), and 21β-benzoyloxy-3β,16β,23-trihydroxyolean-12-ene-28-al 3-O-β-D-glucopyranosyl-(1→3)-α-L-arabinopyranoside (5)...
March 23, 2017: Chemistry & Biodiversity
https://www.readbyqxmd.com/read/28332760/cytotoxic-essential-oils-from-eryngium-campestre-and-eryngium-amethystinum-apiaceae-growing-in-central-italy
#16
Kevin Cianfaglione, Evy E Blomme, Luana Quassinti, Massimo Bramucci, Giulio Lupidi, Stefano Dall'Acqua, Filippo Maggi
Eryngium campestre and E. amethystinum are thorny herbs belonging to the Apiaceae family and spontaneously growing in stony pastures and dry meadows, preferentially on calcareous substrates. In the Mediterranean countries, these plants have been used as a food or traditional remedies to treat various ailments. In the present work, we have analysed the chemical composition of the essential oils distilled from the aerial parts by GC-FID and GC-MS, and evaluated their cytotoxic effects on a panel of human cancer cells, namely A375 (human malignant melanoma), MDA-MB 231 cells (human breast adenocarcinoma) and HCT116 cells (human colon carcinoma), by the MTT assay...
March 23, 2017: Chemistry & Biodiversity
https://www.readbyqxmd.com/read/28323398/chemical-components-from-phaeanthus-vietnamensis-and-their-inhibitory-no-production-in-bv2-cells
#17
Nguyen Xuan Nhiem, Nguyen Trung Tuong, Pham Thanh Ky, Lalita Subedi, SeonJu Park, Tran Minh Ngoc, Pham Hai Yen, Bui Huu Tai, Tran Hong Quang, Phan Van Kiem, Sun Yeou Kim, Seung Hyun Kim
Phaeanthus vietnamensis Ban is a well-known medicinal plant which has been used for the treatment of various inflammatory diseases in traditional medicine. Using various chromatographic methods, three new compounds, (7S,8R,8'R)-3,5,3',5'-tetramethoxy-9,9'-epoxylignan-4,4',7-triol (1), 8α-hydroxyoplop-11(12)-en-14-one (5), and (1R,2S,4S)-2-E-cinnamoyloxy-4-acetyl-1-methylcyclohexan-1-ol (12) along with twelve known compounds were isolated from the leaves of P. vietnamensis. Their chemical structures were elucidated by physical and chemical methods...
March 21, 2017: Chemistry & Biodiversity
https://www.readbyqxmd.com/read/28323385/six-new-acylphloroglucinols-from-dryopteris-championii
#18
Neng-Hua Chen, Yi-Rui Qian, Wen Li, Yu-Bo Zhang, Yi-Duo Zhou, Guo-Qiang Li, Yao-Lan Li, Guo-Cai Wang
Six new acylphloroglucinols (1-6) were isolated from Dryopteris championii. Their structures were established on the basis of extensive analysis of spectroscopic data and comparison with reported data. The antibacterial activities of the isolates were evaluated against Staphylococcus aureus, Escherichia coli, Bacillus subtilis and Dickeya zeae. This article is protected by copyright. All rights reserved.
March 21, 2017: Chemistry & Biodiversity
https://www.readbyqxmd.com/read/28323380/sarcophytrols-g-l-novel-minor-metabolic-components-from-south-china-sea-soft-coral-sarcophyton-trocheliophorum-marenzeller
#19
Lin-Fu Liang, Wen-Ting Chen, Ernesto Mollo, Li-Gong Yao, He-Yao Wang, Wei Xiao, Yue-Wei Guo
Minor metabolic components, six new cembranoids sarcophytrols G - L (1 - 6) along with two known related analogues 7 and 8, were isolated from the South China Sea soft coral Sarcophyton trocheliophorum. Their structures were elucidated by extensive spectroscopic analyses (1D- and 2D-NMR, and ESI-MS.) as well as comparison with literature data. As part of our ongoing research project for discovering bioactive substances from Chinese marine invertebrates, compounds 1 - 8 were tested for their inhibitory activity against protein tyrosine phosphatase 1B (PTP1B), a key target for the treatment of Type-II diabetes and obesity...
March 21, 2017: Chemistry & Biodiversity
https://www.readbyqxmd.com/read/28317320/differential-in-vitro-antitumor-activity-of-essential-oil-of-lippia-citriodora-from-different-regions-in-morocco
#20
Moulay Ali Oukerrou, Mounir Tilaoui, Hassan Ait Mouse, Najat Bouchmaa, Abdelmajid Zyad
The aim of this work was to investigate the in vitro anticancer effect of the essential oil of dried leaves of Lippia citriodora (H.B. & K.) harvested in different regions of Morocco. This effect was evaluated against the P815 murine mastocytoma cell line using the MTT assay. Interestingly, this work demonstrated for the first time that these essential oils exhibited a strong cytotoxic activity against the P815 cell line, with IC50 values ranging from 7.75 μg/ml to 13.25 μg/ml. This cytotoxicity began early and increased in a dose and time dependent manner...
March 19, 2017: Chemistry & Biodiversity
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