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Chemistry & Biodiversity

Takoua Ben Hlel, Feten Belhadj, Fatih Gül, Muhammed Altun, Ayşe ŞahinYağlıoğlu, Ibrahim Demirtaş, M Nejib Marzouki
The present work aimed to determine the antioxidant and antiproliferative potential of Luffa cylindrica fruits collected at two different maturation stages and to identify and compare their functional components composition. The methanolic extracts of L. cylindrica fruits harvested at 60 to 65 days after seeding (S1) and 85 to 90 days after seeding (S2) were investigated for their antioxidant activity using various assays. Furthermore, the antiproliferative activity of the extracts against HeLa human cervical cancer cells was explored with xCELLigence real time cell analyzer while the effect of the samples on the membrane integrity of the same cell line was assessed using LDH cytotoxicity leakage assay...
July 19, 2017: Chemistry & Biodiversity
Sylvain Sutour, Hélène Esselin, Ange Bighelli, Joseph Casanova, Line Le Gall, Félix Tomi
Generic and specific determination among the Laurencia complex is a challenging task. DNA barcoding combined with phenotypic investigations are mandatory for species differentiation. In this study, two morphologically different members of the Laurencia complex were investigated using untargeted (1) H NMR-based metabolomics. Twenty-one population samples were collected in order to evaluate both temporal and geographical homogeneity. Data obtained from (1) H NMR analysis followed by statistical analysis allowed a clear separation of all the samples into two groups...
July 19, 2017: Chemistry & Biodiversity
Anderson R Santos, Thalita Gilda S Benghi, Angelita Nepel, Francisco A Marques, Adriana Q Lobão, Marta Cristina T Duarte, Ana Lúcia T G Ruiz, João E Carvalho, Beatriz H L N S Maia
The essential oils extracted from four species of the genus Guatteria, G.australis, G. ferruginea, G. latifolia and G. sellowiana were analyzed. A total of 24, 22, 25 and 19 constituents of the oils from four species, respectively, were identified by GC-MS. These oils showed qualitative and quantitative differences. All the oils contained the oxygenated sesquiterpenes spathulenol (11.04 - 40.29%) and caryophyllene oxide (7.74 - 40.13%) as predominant constituents. Evaluation of antiproliferative activity of the essential oils showed strong selectivity (1...
July 18, 2017: Chemistry & Biodiversity
Markus Kramer, Clemens Richert
Multicomponent reactions are difficult synthetic transformations. For DNA, there is a special opportunity to align multiple strands in a folded nanostructure, so that they are preorganized to give a specific sequence. Multistrand reactions in DNA origami structures have previously been performed using photochemical crosslinking, 1,3-diploar cycloadditions or phosphoramidate-forming reactions. Here we report carbodiimide-driven phosphodiester formation in a small origami sheet that produces DNA strands up to 600 nucleotides in length in a single step...
July 15, 2017: Chemistry & Biodiversity
Yulia V Gyrdymova, Denis V Sudarikov, Oksana G Shevchenko, Svetlana A Rubtsova, Pavel A Slepukhin, Aleksandr V Kutchin
Caryophyllane thioterpenoids were synthesized in 23-81% yields. The antioxidant properties of the obtained compounds in various model systems were found. It was revealed that 4,5-epoxycaryophyll-9-ylmethanethiol has the greatest antioxidant activity. The isomerism of sesquiterpenic fragments was shown to have a significant effect on the biological activity of the compounds. This article is protected by copyright. All rights reserved.
July 13, 2017: Chemistry & Biodiversity
Basem Guffa, Nebojša M Nedić, Dragana Č Dabić Zagorac, Tomislav B Tosti, Uroš M Gašić, Maja M Natić, Milica M Fotirić Akšić
'Oblačinska' sour cherry, an autochthonous cultivar, is the most planted cultivar in Serbian orchards. Since fruit trees in temperate zone reward insects by producing nectar which 'quality' affects the efficiency of insect pollination, the aim of this study was analyzing of sugars and polyphenolics in floral nectar of 16 'Oblačinska' sour cherry clones with different yielding potential. The contents of sugars and sugar alcohols were analyzed by ion chromatography, while polyphenolic profile was established using liquid chromatography - mass spectrometry technique (LC/MS)...
July 12, 2017: Chemistry & Biodiversity
Lin Hu, Robert K Vander Meer, Sanford D Porter, Li Chen
The cuticular hydrocarbons (CHCs) from hexane rinses of workers from two Florida populations (dark and red forms) of the tropical fire ant, Solenopsis geminata, were separated by silica gel chromatography and identified by GC-MS analysis. Both the dark form and the red form produce similar CHCs with carbon chain lengths ranging from 17 to 35. However, the relative percentages of these CHCs were consistently different between the two color forms. The largest CHC component in the dark form is tricosane, and (Z)-9-tricosene for the red form...
July 11, 2017: Chemistry & Biodiversity
Gaétan Bayiha Ba Njock, Raphaël Grougnet, Antonia Efstathiou, Despina Smirlis, Grégory Genta-Jouve, Sylvie Michel, Joséphine Ngo Mbing, Marina Kritsanida
The study of the MeOH extract of the leaves of Campylospermum excavatum led to the isolation of a nitrile glucoside, named campyloside C (1) and an original derivative of ochnaflavone, 7-O-methylochnaflavone (2) along with three known biflavonoids, amentoflavone, sequoiaflavone, and sotetsuflavone (3-5). The linkage site of the sub-units of 2 was confirmed by chemical correlation, after semi-synthesis of a trimethoxylated derivative of ochnaflavone (2a). The structure of these compounds as well as their relative and absolute configurations were assigned by 1D and 2D NMR experiments, HRESIMS and Electronic Circular Dichroism (ECD) calculations...
July 11, 2017: Chemistry & Biodiversity
Juan Li, Zhao-Xing Li, Jianping Zhao, Wei Wang, Xiao-Fang Zhao, Bo Xu, Lin Li, Lan Zhang, Jie Ren, Ikhlas A Khan, Shun-Xiang Li
A novel tropoloisoquinoline alkaloid, neotatarine (1), was isolated from the 95% ethanol extract of the rhizome parts of Acorus calamus L. The chemical structure was unambiguously elucidated by spectroscopic and single-crystal X-ray diffraction analysis. Neotatarine (1) exhibited significantly inhibitory activity against Aβ25-35 induced PC12 cell death with 2, 4 and 8 μM comparing with the assay control (P < 0.01). This article is protected by copyright. All rights reserved.
July 11, 2017: Chemistry & Biodiversity
Mejra Bektašević, Ivana Carev, Marin Roje, Mladenka Jurin, Olivera Politeo
The phytochemical composition and the antioxidant activities of the essential oil as well as methanol and hot water extracts of endemic Satureja subspicata Vis. growing in Bosnia and Herzegovina (BiH) were described. ß-caryophyllene, cis-ß-ocimene and α-pinene, identified by GC-MS and GC-FID, were dominant oil components. The major compound of both of extracts, identified by HPLC-DAD, was rosmarinic acid. Analyzed essential oil showed moderate antioxidant activity. In this first report on extracts of S. subspicata growing in BiH, the obtained results showed a high content of rosmarinic acid as well as considerable amount of total phenols and flavonoids...
July 10, 2017: Chemistry & Biodiversity
Michiya Kamio, Yasuhiro Nagakura, Hirona Yano
N-Acetyl-D-glucosamino-1,5-lactone (NAGL) 1 has been reported as a candidate component of the sex pheromone mixture of female blue crabs, Callinectes sapidus, since it is present in the urine of reproductive females and males detect it. Theoretically, 1 can convert to a 1,4-lactone isomer 2 or corresponding carboxylic acid, 2-acetamido-2-deoxy-gluconic acid 3 by hydrolysis in aqueous solution. In this study, we examined the biologically relevant state of equilibrium mixture of 1, 2 and 3 in crab urine using ESI-MS and NMR analyses...
July 7, 2017: Chemistry & Biodiversity
Ranjit Ghosh, Manash C Das, Arpita Sarkar, Antu Das, Padmani Sandhu, Biswanath Dinda, Yusuf Akhter, Surajit Bhattacharjee, Utpal Ch De
In the context of ethno botanical importance with no phytochemical investigations, Mussaenda roxburghii have been investigated to explore it's phytoconstituents and studies of their antibiofilm activity. Four compounds have been isolated from the aerial parts of this plant and were characterized as 2α, 3β, 19α, 23-tetrahydroxyurs-12-en-28-oic acid (1), β-sitosterol glucoside (4), lupeol palmitate (5) and myoinositol (6). All these compounds were tested for antibacterial and antibiofilm activity against Pseudomonas aeruginosa...
July 7, 2017: Chemistry & Biodiversity
Opeyemi J Olatunji, Hongxia Chen, Yifeng Zhou
Lycium chinense Miller, popularly known as boxthorn, is a plant that is traditionally used for treating night sweat, cough, inflammation and diabetes mellitus. However, the leaves have received little or no attention despite their potentials as a potent therapeutic agent. This study was aimed at investigating the hypoglycemic and hypolipidemic effects of the polyphenols-rich ethyl acetate fraction from the leaves of Lycium chinense Miller on streptozotocin-nicotinamide induced diabetic rats. The ethyl acetate fraction (LFE) was selected and orally gavaged at 100, 200 and 400 mg/kg dose to streptozotocin (STZ)-nicotinamide induced diabetic rats...
July 4, 2017: Chemistry & Biodiversity
Jia-Yi Sun, Xiao-Xiao Zhang, Li-Xin Niu, Yan-Long Zhang
The aim of this study was to investigate the essential oil (EO) compositions and antioxidant activities from petals of three wild tree peony species (Paeonia delavayi, P. lutea and P. rockii) and eleven P. suffruticosa cultivars from different cultivar groups. The EOs yields varied from 0.63% to 1.25% (v/v) among samples when using supercritical CO2 extraction. One hundred and sixty-three components were detected by GC-MS; and among them, linalool oxide, Z-5-dodecen-1-yl acetate, nonadecane, Z-5-nonadecene, heneicosane, phytol, and linoleic acid ethyl ester were dominant...
July 4, 2017: Chemistry & Biodiversity
A F Tawfike, R Tate, G Abbott, L Young, C Viegelmann, M Schumacher, M Diederich, R A Edrada-Ebel
Endophytic fungi associated with medicinal plants are a potential source of novel chemistry and biology that may find applications as pharmaceutical and agrochemical drugs. In this study, a combination of metabolomics and bioactivity-guided approaches were employed to isolate anticancer secondary metabolites from an endophytic Aspergillus aculeatus. The endophyte was isolated from the Egyptian medicinal plant Terminalia laxiflora and identified using molecular biological methods. Metabolomics and dereplication studies were accomplished by utilizing the MZmine software coupled with the universal Dictionary of Natural Products database...
July 3, 2017: Chemistry & Biodiversity
Kun Zhang, Ying Lin, Zhou-Jian Diao, Wei-Hua Zhang, Sui-Ping Zheng, Shu-Li Liang, Shuang-Yan Han
Citrus essential oils (CEOs) are important flavors in the food and confectionary industries. A lipase process was proposed for enhancing the flavor profiles and increasing the proportions of esters in CEOs. The effects of the enzymatic process were explored by detecting the constituents of the CEOs of American sweet orange oil (ASO) and Brazil mandarin oil (BMO) through GC-MS and sensory evaluation by a trained panel, and positive effects were confirmed by both methods. A further 11 kinds of CEOs were treated via the lipase process and increments of 10% to 1170% were achieved in the proportions of esters, which were mostly ethyl esters...
July 3, 2017: Chemistry & Biodiversity
Sana Wahid, Muhammad Ali Versiani, Sajid Jahangir, Khurshid Jawaid, Maryam Shafique, Huma Khan, Shaheen Faizi
Evaluation of phytochemical constituents and antioxidant and antimicrobial activities of hexane (PELH), dichloromethane (PELDCM), ethyl acetate (PELEA) and methanolic (PELM) extracts of young leaves of P. elegans have been carried out. Moreover, extracts have also been explored for the presence of sulphur containing compounds, 1, 2-dithiolane (33), diallyl disulphide (35), 3-Vinyl-1,2-dithiacyclohex-5-ene (37), diallyl trisulphide (38) responsible for the garlic like smell of P. elegans. All the extracts were found to be antioxidant and showed potent inhibition with IC50 values 0...
July 3, 2017: Chemistry & Biodiversity
Amira Jelassi, Manel Hassine, Malek Besbes Hlila, Hichem Ben Jannet
The genus Acacia is quite large and can be found in the warm subarid and arid parts but little is known about its chemistry, specially the volatile parts. The volatile oils from fresh flowers of A. mollissima and A. cyclops (growing in Tunisia) obtained by hydrodistillation were analyzed by GC then GC-MS. 18 (94.7% of the total oil composition) and 23 (97.4%) compounds were identified in these oils, respectively. (E,E)-α-Farnesene (51.5%) and (E)-cinnamyl alcohol (10.7%) constituted the major compounds of the flower oil of A...
July 3, 2017: Chemistry & Biodiversity
Nam K Nguyen, Xuyen A Truong, Thai Q Bui, Dzung N Bui, Hai X Nguyen, Phuong T Tran, Lien-Hoa D Nguyen
An ethyl acetate extract of the roots of Garcinia fusca produced two new compounds, fuscaxanthones J (1) and K (2), together with eight known xanthones (3-10). Their structures were determined using spectroscopic methods, mainly 1-D and 2-D NMR. α-Glucosidase inhibitory activity of the isolated compounds was evaluated and fuscaxanthone J (1) showed the most significant effect with IC50 value of 8.3 ± 1.8 μM (compared with acarbose, IC50 = 214.5 ± 2.3 μM). This article is protected by copyright. All rights reserved...
June 30, 2017: Chemistry & Biodiversity
Piotr M Kuś, Igor Jerković, Zvonimir Marijanović, Carlo I G Tuberoso
GC-MS of HS-SPME and solvent extractives along with targeted HPLC-DAD of Polish fir (Abies alba Mill.) honeydew honey (FHH), were used to determine the chemical profiles and potential markers of botanical origin. Additionally, typical physical-chemical parameters were also assigned. The values determined for FHH were: conductivity (1.2 mS/cm), water content (16.7 g/100 g), pH (4.5) and CIE chromaticity coordinates (L* = 48.4, a* = 20.6, b* = 69.7, C* = 72.9 and h° = 73.5). FHH contained moderate-high total phenolic content (533...
June 28, 2017: Chemistry & Biodiversity
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