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Current Heart Failure Reports

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https://www.readbyqxmd.com/read/28639234/novel-biomarkers-of-subclinical-cardiac-dysfunction-in-the-general-population
#1
REVIEW
Kamal Shemisa, Anish Bhatt, Daniel Cheeran, Ian J Neeland
PURPOSE OF REVIEW: Recognition of subclinical myocardial dysfunction offers clinicians and patients an opportunity for early intervention and prevention of symptomatic cardiovascular disease. We review the data on novel biomarkers in subclinical heart disease in the general population with a focus on pathophysiology, recent observational or trial data, and potential applicability and pitfalls for clinical use. RECENT FINDINGS: High-sensitivity cardiac troponin and natriuretic peptide assays are powerful markers of subclinical cardiac disease...
June 21, 2017: Current Heart Failure Reports
https://www.readbyqxmd.com/read/28434088/addressing-the-heterogeneity-of-heart-failure-in-future-randomized-trials
#2
REVIEW
Annamaria Iorio, Andrea Pozzi, Michele Senni
PURPOSE OF THE REVIEW: The aim of review is to describe the essential role of study designs beyond RCTs in contemporary contest of HF patients giving perspectives on its evolving. The article concludes with concern about the support of observational studies for future randomized clinical trials. RECENT FINDINGS: With the aging population and spectacular advance in cardiovascular therapy, the clinical syndrome comprising heart failure (HF) is increasingly in complexity of heterogeneity...
April 23, 2017: Current Heart Failure Reports
https://www.readbyqxmd.com/read/28421409/six-minute-walk-test-for-assessing-physical-functional-capacity-in-chronic-heart-failure
#3
REVIEW
Huiyun Du, Parichat Wonggom, Jintana Tongpeth, Robyn A Clark
PURPOSE OF THE REVIEW: The six-minute walk test (6MWT) is a submaximal exercise test for evaluating physical functional capacity. This review aims to report the research on the use of the 6MWT in chronic heart failure (CHF) that has been published in the past 5 years. RECENT FINDINGS: The 6MWT distance does not accurately reflect peak VO2. Minimal clinically important difference in the 6MWT distance, and additional measurements, such as heart rate recovery, can assist in the interpretation of the 6MWT distance, so management decisions can be made...
April 18, 2017: Current Heart Failure Reports
https://www.readbyqxmd.com/read/28455610/inhibition-of-late-sodium-current-as-an-innovative-antiarrhythmic-strategy
#4
REVIEW
Philipp Bengel, Shakil Ahmad, Samuel Sossalla
PURPOSE OF REVIEW: Over the last years, evidence is accumulating that enhanced late sodium current (INaL) in cardiac pathologies has fundamental consequences for cellular electrophysiology. This review discusses the underlying mechanisms of INaL-induced arrhythmias and the significance of INaL-inhibition as a possible therapeutic approach. RECENT FINDINGS: Inhibition of enhanced INaL, e.g., by ranolazine, was shown to reverse these effects in different myocardial diseases including heart failure...
June 2017: Current Heart Failure Reports
https://www.readbyqxmd.com/read/28451983/therapeutic-targeting-of-pdes-and-pi3k-in-heart-failure-with-preserved-ejection-fraction-hfpef
#5
REVIEW
Valentina Sala, Jean Piero Margaria, Alessandra Murabito, Fulvio Morello, Alessandra Ghigo, Emilio Hirsch
PURPOSE OF REVIEW: Heart Failure with preserved Ejection Fraction (HFpEF) is a prevalent disease with considerable individual and societal burden. HFpEF patients often suffer from multiple pathological conditions thatcomplicate management and adversely affect outcome, including pulmonary hypertension and chronic obstructive pulmonary disease (COPD). To date, no treatment proved to be fully effective in reducing morbidity and mortality in HFpEF, possibly due to an incomplete understanding of the underlying molecular mechanisms...
June 2017: Current Heart Failure Reports
https://www.readbyqxmd.com/read/28447290/regulation-of-cardiomyocyte-t-tubular-structure-opportunities-for-therapy
#6
REVIEW
Ornella Manfra, Michael Frisk, William E Louch
PURPOSE OF REVIEW: Membrane invaginations called t-tubules play an integral role in triggering cardiomyocyte contraction, and their disruption during diseases such as heart failure critically impairs cardiac performance. In this review, we outline the growing understanding of the malleability of t-tubule structure and function, and highlight emerging t-tubule regulators which may be exploited for novel therapies. RECENT FINDINGS: New technologies are revealing the nanometer scale organization of t-tubules, and their functional junctions with the sarcoplasmic reticulum called dyads, which generate Ca(2+) sparks...
June 2017: Current Heart Failure Reports
https://www.readbyqxmd.com/read/28421408/pharmacological-and-non-pharmacological-treatment-for-decompensated-heart-failure-what-is-new
#7
REVIEW
Parin Shah, Pierpaolo Pellicori, Joseph Cuthbert, Andrew L Clark
PURPOSE OF THE REVIEW: Acute heart failure (AHF) is a life-threatening clinical condition that requires prompt medical attention. The aim of the current review is to summarise the results of recent clinical trials conducted in patients with AHF. RECENT FINDINGS: Several novel compounds have apparently beneficial acute effects on cardiovascular haemodynamics and patients' symptoms, but their administration has not yet translated into improved survival and has been deleterious in some cases...
June 2017: Current Heart Failure Reports
https://www.readbyqxmd.com/read/28281174/potential-expanded-indications-for-neprilysin-inhibitors
#8
REVIEW
Elizabeth Riddell, Justin M Vader
PURPOSE OF REVIEW: The goal of this article is to review potential expanded indications for neprilysin inhibitors. This article reviews the rationale and design for ongoing and future trials of sacubitril/valsartan in cardiovascular and non-cardiovascular disease. RECENT FINDINGS: Randomized trial data are lacking for use of sacubitril/valsartan in acute heart failure and advanced heart failure. Mechanistic data from animal studies suggest a role for neprilysin inhibition in the treatment of post-myocardial infarction systolic dysfunction and heart failure with preserved ejection fraction...
April 2017: Current Heart Failure Reports
https://www.readbyqxmd.com/read/28247180/registry-based-pragmatic-trials-in-heart-failure-current-experience-and-future-directions
#9
REVIEW
Lars H Lund, Jonas Oldgren, Stefan James
PURPOSE OF REVIEW: Randomized controlled trials (RCTs) in heart failure (HF) are becoming increasingly complex and expensive to conduct and if positive deliver expensive therapy tested only in selected populations. RECENT FINDINGS: Electronic health records and clinical cardiovascular quality registries are providing opportunities for pragmatic and registry-based prospective randomized clinical trials (RRCTs). Simplified regulatory, ethics, and consent procedures; recruitment integrated into real-world care; and simplified or automated baseline and outcome collection allow assessment of study power and feasibility, fast and efficient recruitment, delivery of generalizable findings at low cost, and potentially evidence-based and novel use of generic drugs with low costs to society...
April 2017: Current Heart Failure Reports
https://www.readbyqxmd.com/read/28243969/diuretic-strategies-in-acute-decompensated-heart-failure
#10
REVIEW
E Ashley Hardin, Justin L Grodin
PURPOSE OF REVIEW: The burden of heart failure in the United States is growing rapidly to epic proportions with serious clinical implications for patients and economic strain for healthcare systems. One of the most common reasons for hospitalization in acute decompensated heart failure (ADHF) is excess volume accumulation which leads to untoward symptoms including dyspnea,orthopnea, and edema. RECENT FINDINGS: Over the past several decades, there has been great interest in exploring various decongestive strategies in order to achieve symptomatic improvement and favorable clinical outcomes...
April 2017: Current Heart Failure Reports
https://www.readbyqxmd.com/read/28236161/percutaneous-ventricular-restoration-with-a-partitioning-device-for-ischemic-heart-failure-treatment
#11
REVIEW
Bishnu P Dhakal, Guilherme H Oliveira
PURPOSE OF THE REVIEW: Percutaneous ventricular restoration with a ventricular partitioning device (VPD) is a novel minimally invasive procedure designed to restore the left ventricular (LV) shape by isolating the infarcted and aneurysmal LV apex from remainder of the cavity in heart failure patients with severely reduced LV ejection fraction. In this review, we perform an in-depth analysis of the design and purpose of the VPD and review the available clinical data, with special attention to hemodynamics, outcomes, and complications...
April 2017: Current Heart Failure Reports
https://www.readbyqxmd.com/read/28233259/endothelial-glycocalyx-as-biomarker-for-cardiovascular-diseases-mechanistic-and-clinical-implications
#12
REVIEW
Youn-Hyun Kim, Petra Nijst, Kathryn Kiefer, W H Wilson Tang
INTRODUCTION: The endothelial surface layer is covered with abundant proteoglycans, of which syndecans and glycosaminoglycans are major constituents. RECENT FINDINGS: Among the endothelial glycocalyx (eGC) constituents, syndecan-1 (sdc1) is a main component, and an elevated serum level of sdc1 may indicate the degradation of eGC. In patients with ischemic heart disease or heart failure, elevation of serum sdc1 has been associated with worsening cardiac and renal function; however, the causal relationship between degradation of eGC and clinical outcomes is unclear...
April 2017: Current Heart Failure Reports
https://www.readbyqxmd.com/read/28233258/role-of-the-pharmacist-for-improving-self-care-and-outcomes-in-heart-failure
#13
REVIEW
Daya Ram Parajuli, Julie Franzon, Ross A McKinnon, Sepehr Shakib, Robyn A Clark
PURPOSE OF REVIEW: This review highlights the current and emerging approaches for the role of the pharmacist for improving self-care and outcomes in heart failure management. RECENT FINDINGS: Pharmacists are contributing to heart failure management in a variety of settings, including hospitals, clinics, and communities. Different interventions which may be mediated by the pharmacist include drug adherence, discharge counseling, medication reconciliation, telephone follow-up, and recommendation of evidence-based medicines...
April 2017: Current Heart Failure Reports
https://www.readbyqxmd.com/read/28215031/orexin-a-missing-link-between-sleep-disorders-and-heart-failure
#14
REVIEW
Stephen Pan, Carolina S Cabral, Euan A Ashley, Marco V Perez
PURPOSE OF REVIEW: Sleep disorders represent a significant comorbidity in the heart failure population, and there is mounting evidence that treatment of sleep disorders such as obstructive sleep apnea can significantly improve cardiac function. However, the link between these two disorders is still not entirely clear. RECENT FINDINGS: Recently, a novel neurohormonal pathway has been elucidated involving signaling molecules now collectively known as the orexins, which have been implicated in regulating autonomic function during sleep/wake cycles...
April 2017: Current Heart Failure Reports
https://www.readbyqxmd.com/read/28213768/factors-related-to-self-care-in-heart-failure-patients-according-to-the-middle-range-theory-of-self-care-of-chronic-illness-a-literature-update
#15
REVIEW
Tiny Jaarsma, Jan Cameron, Barbara Riegel, Anna Stromberg
PURPOSE OF THE REVIEW: As described in the theory of self-care in chronic illness, there is a wide range of factors that can influence self-care behavior. The purpose of this paper is to summarize the recent heart failure literature on these related factors in order to provide an overview on which factors might be suitable to be considered to make self-care interventions more successful. RECENT FINDINGS: Recent studies in heart failure patients confirm that factors described in the theory of self-care of chronic illness are relevant for heart failure patients...
April 2017: Current Heart Failure Reports
https://www.readbyqxmd.com/read/28205040/clinical-phenotyping-of-heart-failure-with-biomarkers-current-and-future-perspectives
#16
REVIEW
Vichai Senthong, Jennifer L Kirsop, W H Wilson Tang
INTRODUCTION: Heart failure (HF) is a complex clinical syndrome with diverse risk factors and etiologies, differing underlying pathophysiology, and large phenotypic heterogeneity. RECENT FINDINGS: Advances in imaging techniques coupled with clinical trials that targeted only in those with impaired left ventricular ejection fraction (LVEF) have largely shaped the current management strategy for HF that focuses predominantly in patients with systolic HF. In contrast, there are no effective treatments for HF with preserved ejection fraction (HFpEF)...
April 2017: Current Heart Failure Reports
https://www.readbyqxmd.com/read/28243968/detecting-and-managing-cognitive-impairment-to-improve-engagement-in-heart-failure-self-care
#17
REVIEW
Jan Cameron, Robyn Gallagher, Susan J Pressler
PURPOSE OF THE REVIEW: The purpose of this review was to examine the recent literature on detecting cognitive impairment in patients with heart failure (HF) and the evidence indicating any ramifications of cognitive impairment on patient engagement in HF self-care. RECENT FINDINGS: Mild cognitive impairment (MCI) is common in HF and impacts on patients' engagement in self-care, yet it is frequently not detected. The use of screening tools, even when brief, improves detection of MCI...
February 27, 2017: Current Heart Failure Reports
https://www.readbyqxmd.com/read/28210847/ethical-considerations-in-the-long-term-ventricular-assist-device-patient
#18
REVIEW
Amanda Cai, Howard J Eisen
PURPOSE OF REVIEW: As the heart failure population continues to age, the need for definitive therapies such as ventricular assist devices (VADs) to extend life and alleviate suffering from end-stage disease directly increases. The goal of this article is to examine the ethical principles of autonomy, beneficence, non-maleficence, and justice within the context of long-term VAD patients. RECENT FINDINGS: Survival rates in VAD-implanted patients have improved in parallel with modernization of device design and surgical technique, reaching that of cardiac transplantation at 1 year post-procedure...
February 16, 2017: Current Heart Failure Reports
https://www.readbyqxmd.com/read/28190189/towards-precision-in-hf-pharmacotherapy
#19
REVIEW
Nicholas B Norgard, Carolyn Hempel
PURPOSE OF REVIEW: Heart failure (HF) is a disease state with great heterogeneity, which complicates the therapeutic process. Identifying more precise HF phenotypes will allow for the development of more targeted therapies and improvement in patient outcomes. This review explores the future for precision medicine in HF treatment. RECENT FINDINGS: Rather than a continuous disease spectrum with a uniform pathogenesis, HF has phenotypes with different underlying pathophysiologic features...
February 11, 2017: Current Heart Failure Reports
https://www.readbyqxmd.com/read/28185163/global-variations-in-patient-populations-and-outcomes-in-heart-failure-clinical-trials
#20
REVIEW
Chidiebube Egwim, Brittany Dixon, Andrew P Ambrosy, Robert J Mentz
Heart failure is a global pandemic and there has been a growing effort to enroll patients from different geographical regions in randomized controlled trials. In this review, we examined regional variation in both patient characteristics and outcomes among several of the most recent global heart failure trials RECENT FINDINGS: Retrospective analyses of global heart failure trials have identified marked variations in both baseline characteristics and management of heart failure by region of enrollment. In some trials, this variation has been significant enough to cause differential treatment effects...
February 9, 2017: Current Heart Failure Reports
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