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Current Heart Failure Reports

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https://www.readbyqxmd.com/read/29744760/correction-to-vitamin-d-and-heart-failure
#1
D Marshall Brinkley, Omair M Ali, Sandip K Zalawadiya, Thomas J Wang
The original version of this article, published in Current Heart Failure Reports, Volume 14, Issue 5, October 2017, erroneously cited an author's name as Marshall Brinkley, D" when it should be "Brinkley, DM."
April 30, 2018: Current Heart Failure Reports
https://www.readbyqxmd.com/read/29707741/myocardial-energetics-and-heart-failure-a-review-of-recent-therapeutic-trials
#2
REVIEW
Kunal N Bhatt, Javed Butler
PURPOSE OF REVIEW: Several novel therapeutics being tested in patients with heart failure are based on myocardial energetics. This review will provide a summary of the recent trials in this area, including therapeutic options targeting various aspects of cellular and mitochondrial metabolism. RECENT FINDINGS: Agents that improve the energetic balance in myocardial cells have the potential to improve clinical heart failure status. The most promising therapies currently under investigation in this arena include (1) elamipretide, a cardiolipin stabilizer; (2) repletion of iron deficiency with intravenous ferrous carboxymaltose; (3) coenzyme Q10; and (4) the partial adenosine receptor antagonists capadenoson and neladenosone...
April 30, 2018: Current Heart Failure Reports
https://www.readbyqxmd.com/read/29700697/essential-elements-of-early-post-discharge-care-of-patients-with-heart-failure
#3
REVIEW
Richard J Soucier, P Elliott Miller, Joseph J Ingrassia, Ralph Riello, Nihar R Desai, Tariq Ahmad
PURPOSE OF REVIEW: Heart failure is associated with an enormous burden on both patients and health care systems in the USA. Several national policy initiatives have focused on improving the quality of heart failure care, including reducing readmissions following hospitalization, which are common, costly, and, at least in part, preventable. The transition from inpatient to ambulatory care setting and the immediate post-hospitalization period present an opportunity to further optimize guideline concordant medical therapy, identify reversible issues related to worsening heart failure, and evaluate prognosis...
April 26, 2018: Current Heart Failure Reports
https://www.readbyqxmd.com/read/29629485/has-the-time-come-to-be-more-aggressive-with-bariatric-surgery-in-obese-patients-with-chronic-systolic-heart-failure
#4
REVIEW
Amanda R Vest
PURPOSE OF REVIEW: Obesity is a strong risk factor for the development of heart failure (HF). Diet, exercise, and weight-loss pharmacotherapies have limited potential to achieve significant and sustainable weight loss, especially in patients with symptomatic systolic HF. This review seeks to determine the role of bariatric surgery for patients with systolic HF and obesity. RECENT FINDINGS: Bariatric surgeries such as the laparoscopic sleeve gastrectomy (LSG) and Roux-en-Y gastric bypass (RYGB) represent the most successful long-term strategy for achieving weight loss and diabetes and hypertension remission in the general obese population...
April 8, 2018: Current Heart Failure Reports
https://www.readbyqxmd.com/read/29623530/novel-insights-and-treatment-strategies-for-right-heart-failure
#5
REVIEW
Weiqin Lin, Ai-Ling Poh, W H Wilson Tang
PURPOSE OF REVIEW: The function of the right ventricle (RV) is intimately linked to its preload (systemic volume status) and afterload (pulmonary vasculature). In this review, we explore current knowledge in RV physiology, RV function assessment, causes of right heart failure (RHF), and specific treatment strategies for RHF. RECENT FINDINGS: We examine the evidence behind new pharmacological therapies available, such as macitentan and riociguat in the treatment of specific etiologies of RHF...
April 6, 2018: Current Heart Failure Reports
https://www.readbyqxmd.com/read/29623529/nutritional-interventions-in-heart-failure-challenges-and-opportunities
#6
REVIEW
Conor P Kerley
PURPOSE OF REVIEW: There is a growing body of evidence that nutritional factors influence the incidence of heart failure (HF). The current manuscript aims to collate evidence relating to nutritional intervention in the treatment of HF as well as to provide context regarding challenges and opportunities in the field. RECENT FINDINGS: Despite the accepted importance of nutritional factors relating to cardiovascular disease severity, there is surprisingly little human intervention research regarding dietary intake and HF...
April 6, 2018: Current Heart Failure Reports
https://www.readbyqxmd.com/read/29616491/management-of-sleep-disordered-breathing-in-patients-with-heart-failure
#7
REVIEW
Connor P Oates, Manjula Ananthram, Stephen S Gottlieb
PURPOSE OF REVIEW: This paper reviews treatment options for sleep disordered breathing (SDB) in patients with heart failure. We sought to identify therapies for SDB with the best evidence for long-term use in patients with heart failure and to minimize uncertainties in clinical practice by examining frequently discussed questions: what is the role of continuous positive airway pressure (CPAP) in patients with heart failure? Is adaptive servo-ventilation (ASV) safe in patients with heart failure? To what extent is SDB a modifiable risk factor? RECENT FINDINGS: Consistent evidence has demonstrated that the development of SDB in patients with heart failure is a poor prognostic indicator and a risk factor for cardiovascular mortality...
April 3, 2018: Current Heart Failure Reports
https://www.readbyqxmd.com/read/29667071/optimizing-cardiac-resynchronization-therapy-an-update-on-new-insights-and-advancements
#8
REVIEW
Adam Grimaldi, Eiran Z Gorodeski, John Rickard
PURPOSE OF REVIEW: This review focuses on the current advancements in optimizing patient response to cardiac resynchronization therapy (CRT). RECENT FINDINGS: It has been well known that not every patient will derive benefit from CRT, and of those that do, there are varying levels of response. Optimizing CRT begins well before device implant and involves appropriate patient selection and an understanding of the underlying substrate. After implant, there are different CRT device programming options that can be enabled to help overcome barriers as to why a patient may not respond...
June 2018: Current Heart Failure Reports
https://www.readbyqxmd.com/read/29616492/contraceptive-strategies-in-women-with-heart-failure-or-with-cardiac-transplantation
#9
REVIEW
Anjli Maroo, Johnny Chahine
PURPOSE OF REVIEW: We describe contraception for two groups of women: (1) women with heart failure and (2) women with cardiac transplantation. RECENT FINDINGS: Medical Eligibility Criteria for contraceptive agents address women with peripartum cardiomyopathy and women with valvular heart disease (Curtis et al. MMWR Recomm Rep 65:1-103, 2016). Recommendations for women with other forms of heart failure are extrapolated from these populations. Recommendations for women with cardiac transplantation have shifted since the 1980s: use of long-acting reversible contraception has increased, and there is a better understanding of the interactions between contraceptive and immunosuppressive regimens...
June 2018: Current Heart Failure Reports
https://www.readbyqxmd.com/read/29520707/biomarkers-of-cardiac-stress-and-injury-in-athletes-what-do-they-mean
#10
REVIEW
Eoin Donnellan, Dermot Phelan
PURPOSE OF THE REVIEW: Markers of myocardial stress, including troponin, creatine kinase, and brain natriuretic peptide are frequently elevated after endurance athletic pursuits. Here, we summarize the current literature pertaining to the potential mechanism of cardiac enzyme release in athletes and seek to determine the clinical implications of these findings. RECENT FINDINGS: Recent studies have highlighted the potential adverse cardiac effects of long-term extreme endurance exercise...
April 2018: Current Heart Failure Reports
https://www.readbyqxmd.com/read/29520706/the-evolving-role-of-cardiorespiratory-fitness-and-exercise-in-prevention-and-management-of-heart-failure
#11
REVIEW
Wally Omar, Ambarish Pandey, Mark J Haykowsky, Jarett D Berry, Carl J Lavie
PURPOSE OF REVIEW: This paper highlights the dynamic relationship between cardiorespiratory fitness (CRF) and heart failure (HF). As heart failure with preserved ejection fraction (HFpEF) surpasses heart failure with reduced ejection fraction (HFrEF) in prevalence, our void in understanding how to treat this syndrome becomes less justifiable. As such, significant attention has been given to the role that obesity and physical inactivity play, as both risk factors for heart failure, and therapeutic targets for its treatment...
April 2018: Current Heart Failure Reports
https://www.readbyqxmd.com/read/29480349/fill-in-the-gaps-of-secondary-mitral-regurgitation-a-continuum-challenge-from-pathophysiology-to-prognosis
#12
REVIEW
Riccardo M Inciardi, Andrea Rossi, Giovanni Benfari, Mariantonietta Cicoira
PURPOSE OF REVIEW: Mitral regurgitation (MR) is one of the most frequent valvular heart diseases encountered in clinical practice. In contrast to primary MR, less is still known about the pathophysiology, diagnosis, and prognosis of secondary MR. The purpose of this report is to provide a review, upon the last knowledge reported in the literature, on the role and management of secondary MR in clinical practice. RECENT FINDINGS: Recent data highlight secondary MR not as a single pathological entity but as a wide spectrum of interconnected conditions which portend poor outcome...
April 2018: Current Heart Failure Reports
https://www.readbyqxmd.com/read/29476326/multiple-avenues-of-modulating-the-nitric-oxide-pathway-in-heart-failure-clinical-trials
#13
REVIEW
Prabhjot Singh, Shilpa Vijayakumar, Andreas Kalogeroupoulos, Javed Butler
PURPOSE OF REVIEW: This review discusses the integral role of the nitric oxide (NO) pathway in the pathophysiology of heart failure (HF). We emphasize potential therapeutic targets in the NO pathway and review contemporary clinical trials evaluating these novel therapeutic options. RECENT FINDINGS: Nitrates, neprilysin inhibitors, and phosphodiesterase (PDE) inhibitors have all proven to be efficacious in HF patients with systolic dysfunction, with the former two classes of medications producing a net mortality benefit...
April 2018: Current Heart Failure Reports
https://www.readbyqxmd.com/read/29468530/the-future-of-biomarker-guided-therapy-for-heart-failure-after-the-guiding-evidence-based-therapy-using-biomarker-intensified-treatment-in-heart-failure-guide-it-study
#14
REVIEW
Nasrien E Ibrahim, James L Januzzi
PURPOSE OF REVIEW: Biomarker-guided management of patients with chronic heart failure with reduced ejection fraction (HFrEF) remains controversial. RECENT FINDINGS: Biomarkers have established roles for diagnosis and prognostication in HF. Pilot data suggested that use of natriuretic peptides might be helpful to guide HF care. The recent Guiding Evidence-Based Therapy Using Biomarker Intensified Treatment in Heart Failure (GUIDE-IT) randomized-controlled trial did not find therapy guided by NT-proBNP to be more effective than usual care in improving the primary endpoint of HF hospitalization or cardiovascular mortality amongst patients with chronic HFrEF...
April 2018: Current Heart Failure Reports
https://www.readbyqxmd.com/read/29468529/right-ventricular-dysfunction-and-its-contribution-to-morbidity-and-mortality-in-left-ventricular-heart-failure
#15
REVIEW
Amresh Raina, Talha Meeran
PURPOSE: In patients with left-sided HF, there has been less emphasis on the pathophysiology of the RV in terms of diagnostic evaluation and treatment, versus focus on structural abnormalities of the LV. This review seeks to delineate the importance of RV dysfunction in terms of its contribution to symptomatic limitations and cardiovascular outcomes in patients with left-sided HF. RECENT FINDINGS: Recent studies have demonstrated that RV dysfunction is common in both HFpEF and HFrEF, but more pronounced in HFrEF...
April 2018: Current Heart Failure Reports
https://www.readbyqxmd.com/read/29455273/updates-on-device-based-therapies-for-patients-with-heart-failure
#16
REVIEW
Jad Al Danaf, Javed Butler, Amin Yehya
PURPOSE OF REVIEW: Heart failure is a growing epidemic. Optimal medical therapy remains the cornerstone of heart failure management but device-based therapies have been shown to contribute to morbidity and mortality reduction. RECENT FINDINGS: Multiple investigational trials had been conducted in the past decade that helped us better understand and manage heart failure. In this manuscript, we will discuss the major device related trials of year 2017 in the fields of defibrillators, hemodynamic monitoring, remote monitoring, autonomic nervous system modulation, ventricular assist devices, and device-based valvular heart disease management...
April 2018: Current Heart Failure Reports
https://www.readbyqxmd.com/read/29435789/chronic-right-ventricular-pacing-in-the-heart-failure-population
#17
REVIEW
Justin Gould, Benjamin Sieniewicz, Bradley Porter, Baldeep Sidhu, Christopher A Rinaldi
PURPOSE OF REVIEW: We review the trials that have demonstrated potentially harmful effects from right ventricular (RV) apical pacing as well as reviewing the evidence of alternative RV pacing sites and cardiac resynchronization therapy (CRT) for patients who have heart failure and atrioventricular (AV) block. RECENT FINDINGS: The role of CRT in patients with AV block and impaired left ventricular function remains an important consideration. The BLOCK HF trial demonstrated better outcomes with CRT pacing over RV pacing in patients with left ventricular systolic dysfunction (LVSD) and AV block who were expected to have a high RV pacing burden, but failed to demonstrate a mortality benefit...
April 2018: Current Heart Failure Reports
https://www.readbyqxmd.com/read/29435788/the-psychosocial-treadmill-the-road-to-improving-high-risk-behavior-in-advanced-therapy-candidates
#18
REVIEW
Laura Newman
PURPOSE OF REVIEW: The purpose of this review is to explore the evaluation and identification of psychosocial risk factors during the heart transplant evaluation process with the goal of improving psychosocial candidacy prior to transplant listing. Subsequently, more patients will be able to receive life-saving heart transplant and experience success after transplant. RECENT FINDINGS: Evaluating and identifying psychosocial risk factors is an essential component of the transplant evaluation process...
April 2018: Current Heart Failure Reports
https://www.readbyqxmd.com/read/29417467/pulmonary-vascular-disease-hemodynamic-assessment-and-treatment-selection-focus-on-group-ii-pulmonary-hypertension
#19
REVIEW
Bhavadharini Ramu, Brian A Houston, Ryan J Tedford
PURPOSE OF REVIEW: Pulmonary hypertension due to left heart disease (PH-LHD) is the most common cause of pulmonary hypertension worldwide, yet therapies used to treat pulmonary arterial hypertension have failed to show efficacy in this population. Proper hemodynamic assessment and differentiation of pulmonary hypertension phenotypes is therefore critical for both current clinical practice and future research and therapeutic efforts. RECENT FINDINGS: Substantial recent efforts have sought to improve the hemodynamic characterization of pulmonary hypertension for both diagnostic and prognostic purposes...
April 2018: Current Heart Failure Reports
https://www.readbyqxmd.com/read/29404976/an-appraisal-of-biomarker-based-risk-scoring-models-in-chronic-heart-failure-which-one-is-best
#20
REVIEW
Barbara S Doumouras, Douglas S Lee, Wayne C Levy, Ana C Alba
PURPOSE OF REVIEW: While prediction models incorporating biomarkers are used in heart failure, these have shown wide-ranging discrimination and calibration. This review will discuss externally validated biomarker-based risk models in chronic heart failure patients assessing their quality and relevance to clinical practice. RECENT FINDINGS: Biomarkers may help in determining prognosis in chronic heart failure patients as they reflect early pathologic processes, even before symptoms or worsening disease...
February 2018: Current Heart Failure Reports
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