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Current Heart Failure Reports

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https://www.readbyqxmd.com/read/30178183/impaired-exercise-tolerance-in-heart-failure-role-of-skeletal-muscle-morphology-and-function
#1
REVIEW
Wesley J Tucker, Mark J Haykowsky, Yaewon Seo, Elisa Stehling, Daniel E Forman
PURPOSE OF REVIEW: To discuss the impact of deleterious changes in skeletal muscle morphology and function on exercise intolerance in patients with heart failure with reduced ejection fraction (HFrEF) and heart failure with preserved ejection fraction (HFpEF), as well as the utility of exercise training and the potential of novel treatment strategies to preserve or improve skeletal muscle morphology and function. RECENT FINDINGS: Both HFrEF and HFpEF patients exhibit a reduction in percent of type I (oxidative) muscle fibers and oxidative enzymes coupled with abnormal mitochondrial respiration...
September 3, 2018: Current Heart Failure Reports
https://www.readbyqxmd.com/read/30171472/diastolic-stress-testing-along-the-heart-failure-continuum
#2
REVIEW
T Jake Samuel, Rhys Beaudry, Satyam Sarma, Vlad Zaha, Mark J Haykowsky, Michael D Nelson
PURPOSE OF REVIEW: This review summarizes recent developments highlighting the clinical utility of diastolic stress testing along the heart failure continuum. RECENT FINDINGS: Invasive hemodynamic assessment of cardiac filling pressures during physiological stress is the gold-standard technique for unmasking diastolic dysfunction. Non-invasive surrogate techniques, such as Doppler ultrasound, have shown excellent agreement with invasive approaches and are now recommended by the American Society of Echocardiography and the European Association of Cardiovascular Imaging...
September 1, 2018: Current Heart Failure Reports
https://www.readbyqxmd.com/read/29987499/decompensated-heart-failure-and-renal-failure-what-is-the-current-evidence
#3
REVIEW
Agata Bielecka-Dabrowa, Breno Godoy, Joerg C Schefold, Michael Koziolek, Maciej Banach, Stephan von Haehling
PURPOSE OF REVIEW: Acute decompensated heart failure (ADHF) is one of the biggest challenges in the management of chronic heart failure. Despite several advances in medical and device therapy, high readmission and mortality rates continue to be a burden on healthcare systems worldwide. The aim of the current review is to provide an overview on current as well as future approaches in cardiorenal interactions in patients with ADHF. RECENT FINDINGS: One of the strongest predictors of adverse outcomes in ADHF is renal dysfunction, referred to as cardiorenal syndromes (CRS) or cardiorenal interactions...
July 10, 2018: Current Heart Failure Reports
https://www.readbyqxmd.com/read/29987498/the-confounding-effects-of-non-cardiac-pathologies-on-the-interpretation-of-cardiac-biomarkers
#4
REVIEW
Marin Nishimura, Alison Brann, Kay-Won Chang, Alan S Maisel
PURPOSE OF REVIEW: Cardiac biomarkers play important roles in routine evaluation of cardiac patients. But while these biomarkers can be extremely valuable, none of them should ever be used by themselves-without adding the clinical context. This paper explores the non-cardiac pathologies that can be seen with the cardiac biomarkers most commonly used. RECENT FINDINGS: High-sensitivity troponin assay gained FDA approval for use in the USA, and studies demonstrated its diagnostic utility can be extended to patients with renal impairment...
July 10, 2018: Current Heart Failure Reports
https://www.readbyqxmd.com/read/29938322/decompensated-heart-failure-with-ventricular-arrhythmia-how-useful-is-vt-ablation
#5
REVIEW
Gerasimos Dimitropoulos, Georgios Leventogiannis, Joseph De Bono
PURPOSE OF REVIEW: Ventricular arrhythmias are common in patients with heart failure. Their management especially in the context of decompensated heart failure poses a clinical challenge to modern cardiologists. In this review article, we aim to summarise the current evidence on the epidemiology, pathophysiology, and management of ventricular tachycardia in heart failure, focusing primarily on the use of catheter ablation. RECENT FINDINGS: The evolution of electro-anatomical mapping techniques and ablation catheter technology in the recent years has paved the path for the successful application of catheter ablation in the treatment of ventricular arrhythmias...
June 25, 2018: Current Heart Failure Reports
https://www.readbyqxmd.com/read/29938321/prevention-of-cardiotoxicities-with-traditional-and-novel-chemotherapeutic-agents
#6
REVIEW
Zarina Sharalaya, Patrick Collier
PURPOSE OF REVIEW: This review will discuss strategies to prevent cardiotoxicity associated with chemotherapeutics. Forty years ago, investigators identified dose-dependent cardiotoxicity related to anthracycline-based regimens. Over recent decades, the development of more selective, mechanism-based chemotherapeutics has been associated with both on-target and off-target adverse cardiovascular sequelae. RECENT FINDINGS: Strategies to prevent or attenuate cardiotoxicities include limitation of anthracycline dose, appropriate patient selection, referral/access to cardio-oncology programs, early recognition of cardiac side effects, active cardio-surveillance, cardio-protective medical therapy, treatment-specific concerns, and follow-up...
June 25, 2018: Current Heart Failure Reports
https://www.readbyqxmd.com/read/30123941/cardiorenal-interactions-revisited-how-to-improve-heart-failure-outcomes-in-patients-with-chronic-kidney-disease
#7
REVIEW
Mattia Arrigo, Pietro E Cippà, Alexandre Mebazaa
PURPOSE OF THE REVIEW: To summarize current advances in the understanding and management of heart failure (HF) in patients with advanced chronic kidney disease (CKD). RECENT FINDINGS: Diagnosis of HF and treatment of congestion are crucial in the management of patients with advanced CKD to reduce symptoms, preserve organ function, and improve outcomes. Echocardiography and cardiovascular biomarkers may help to differentiate cardiac from non-cardiac components of overhydration...
October 2018: Current Heart Failure Reports
https://www.readbyqxmd.com/read/30097910/non-response-to-cardiac-resynchronization-therapy
#8
REVIEW
Syed Yaseen Naqvi, Anas Jawaid, Ilan Goldenberg, Valentina Kutyifa
PURPOSE OF REVIEW: Cardiac resynchronization therapy (CRT) is an effective treatment option for therapy-refractory mild to severe heart failure (HF) patients with reduced ejection fraction and left ventricular (LV) conduction delay. Multiple clinical trials have shown that CRT improves cardiac function and overall quality of life, as well as reduces HF hospitalizations, health care costs, and mortality. RECENT FINDINGS: Despite its effectiveness, the "non-response" rate to CRT is around 30%, remaining a major challenge that faces electrophysiologists and researchers...
October 2018: Current Heart Failure Reports
https://www.readbyqxmd.com/read/30062624/clinical-implications-of-serum-biomarkers-of-cardiac-stress-in-aortic-stenosis
#9
REVIEW
Nimesh Patel, Dharam J Kumbhani
PURPOSE OF REVIEW: The purpose of this review is to outline the relationship between serum biomarkers of cardiac stress and the pathophysiologic progression of aortic stenosis, to identify studies exploring the utility of biomarkers in the risk stratification and management of patients with aortic stenosis, and to highlight the biomarkers most practical to management of patients with aortic stenosis. RECENT FINDINGS: Several biomarkers have been identified that reflect various aspects of the pathogenesis of calcific aortic stenosis, subsequent hemodynamic obstruction leading to myocardial remodeling, oxidative stress and injury, and concomitant systemic inflammation...
October 2018: Current Heart Failure Reports
https://www.readbyqxmd.com/read/30062623/heart-failure-and-stroke
#10
REVIEW
Katja Schumacher, Jelena Kornej, Eduard Shantsila, Gregory Y H Lip
PURPOSE: Ischemic stroke significantly contributes to morbidity and mortality in heart failure (HF). The risk of stroke increases significantly, with coexisting atrial fibrillation (AF). An aggravating factor could be asymptomatic paroxysms of AF (so-called silent AF), and therefore, the risk stratification in these patients remains difficult. This review provides an overview of stroke risk in HF, its risk stratification, and stroke prevention in these patients. RECENT FINDINGS: Stroke risk stratification in HF patients remains an important issue...
October 2018: Current Heart Failure Reports
https://www.readbyqxmd.com/read/30051292/peripartum-cardiomyopathy-an-update
#11
REVIEW
Feriel Azibani, Karen Sliwa
PURPOSE OF REVIEW: Peripartum cardiomyopathy (PPCM) is an idiopathic disorder defined as heart failure occurring in women during the last month of pregnancy and up to 5 months postpartum. In this review, we outline recent reports about the disease pathogenesis and management and highlight the use of diagnosis and prognosis biomarkers. RECENT FINDINGS: Novel data strengthen the implication of endothelial function in PPCM pathogenesis. The first international registry showed that patient presentations were similar globally, with heterogeneity in patient management and outcome...
October 2018: Current Heart Failure Reports
https://www.readbyqxmd.com/read/29971612/the-effect-of-left-ventricular-assist-device-therapy-on-cardiac-biomarkers-implications-for-the-identification-of-myocardial-recovery
#12
REVIEW
Luise Holzhauser, Gene Kim, Gabriel Sayer, Nir Uriel
PURPOSE OF REVIEW: Left ventricular assist device (LVAD) therapy serves as mainstay therapy for bridge to transplantation and destination therapy. Evidence is now mounting on the role of LVAD therapy as bridge to recovery. In the current review, we will summarize the data on biomarkers of myocardial recovery following LVAD implantation. RECENT FINDINGS: Myocardial recovery can occur spontaneously, following pharmacological intervention and in the setting of mechanical circulatory support such as LVAD...
August 2018: Current Heart Failure Reports
https://www.readbyqxmd.com/read/29959688/identifying-and-managing-hibernating-myocardium-what-s-new-and-what-remains-unknown
#13
REVIEW
Matthew J Ryan, Divaka Perera
PURPOSE OF REVIEW: Hibernation is an important and reversible cause of myocardial dysfunction in ischaemic heart failure. RECENT FINDINGS: Hibernation is an adaptive process that promotes myocyte survival over maintaining contractile function. It is innate to mammalian physiology, sharing features with physiological hibernation in other species. Advanced imaging methods have reasonable accuracy in identifying hibernating myocardium. Novel superior hybrid methods may provide diagnostic potential...
August 2018: Current Heart Failure Reports
https://www.readbyqxmd.com/read/29951883/pharmacologic-management-of-cancer-therapeutics-induced-cardiomyopathy-in-adult-cancer-survivors
#14
REVIEW
J Emanuel Finet, Gregory A Wiggers
PURPOSE OF REVIEW: The number of cancer survivors is exponentially increasing worldwide, due to both advances in cancer detection and treatment strategies, as well as the aging and growth of the population. This decrease in cancer mortality has brought forth a concurrent increase of non-ischemic (toxic) dilated cardiomyopathy in the survivor population, also known as cancer therapeutics-induced cardiomyopathy (CTIC). The optimal pharmacological management for this condition is still elusive, and hence, the focus of this work...
August 2018: Current Heart Failure Reports
https://www.readbyqxmd.com/read/29943347/complicated-acute-heart-failure-subsets
#15
REVIEW
Prithwish Banerjee
No abstract text is available yet for this article.
August 2018: Current Heart Failure Reports
https://www.readbyqxmd.com/read/29707741/myocardial-energetics-and-heart-failure-a-review-of-recent-therapeutic-trials
#16
REVIEW
Kunal N Bhatt, Javed Butler
PURPOSE OF REVIEW: Several novel therapeutics being tested in patients with heart failure are based on myocardial energetics. This review will provide a summary of the recent trials in this area, including therapeutic options targeting various aspects of cellular and mitochondrial metabolism. RECENT FINDINGS: Agents that improve the energetic balance in myocardial cells have the potential to improve clinical heart failure status. The most promising therapies currently under investigation in this arena include (1) elamipretide, a cardiolipin stabilizer; (2) repletion of iron deficiency with intravenous ferrous carboxymaltose; (3) coenzyme Q10; and (4) the partial adenosine receptor antagonists capadenoson and neladenosone...
June 2018: Current Heart Failure Reports
https://www.readbyqxmd.com/read/29700697/essential-elements-of-early-post-discharge-care-of-patients-with-heart-failure
#17
REVIEW
Richard J Soucier, P Elliott Miller, Joseph J Ingrassia, Ralph Riello, Nihar R Desai, Tariq Ahmad
PURPOSE OF REVIEW: Heart failure is associated with an enormous burden on both patients and health care systems in the USA. Several national policy initiatives have focused on improving the quality of heart failure care, including reducing readmissions following hospitalization, which are common, costly, and, at least in part, preventable. The transition from inpatient to ambulatory care setting and the immediate post-hospitalization period present an opportunity to further optimize guideline concordant medical therapy, identify reversible issues related to worsening heart failure, and evaluate prognosis...
June 2018: Current Heart Failure Reports
https://www.readbyqxmd.com/read/29667071/optimizing-cardiac-resynchronization-therapy-an-update-on-new-insights-and-advancements
#18
REVIEW
Adam Grimaldi, Eiran Z Gorodeski, John Rickard
PURPOSE OF REVIEW: This review focuses on the current advancements in optimizing patient response to cardiac resynchronization therapy (CRT). RECENT FINDINGS: It has been well known that not every patient will derive benefit from CRT, and of those that do, there are varying levels of response. Optimizing CRT begins well before device implant and involves appropriate patient selection and an understanding of the underlying substrate. After implant, there are different CRT device programming options that can be enabled to help overcome barriers as to why a patient may not respond...
June 2018: Current Heart Failure Reports
https://www.readbyqxmd.com/read/29629485/has-the-time-come-to-be-more-aggressive-with-bariatric-surgery-in-obese-patients-with-chronic-systolic-heart-failure
#19
REVIEW
Amanda R Vest
PURPOSE OF REVIEW: Obesity is a strong risk factor for the development of heart failure (HF). Diet, exercise, and weight-loss pharmacotherapies have limited potential to achieve significant and sustainable weight loss, especially in patients with symptomatic systolic HF. This review seeks to determine the role of bariatric surgery for patients with systolic HF and obesity. RECENT FINDINGS: Bariatric surgeries such as the laparoscopic sleeve gastrectomy (LSG) and Roux-en-Y gastric bypass (RYGB) represent the most successful long-term strategy for achieving weight loss and diabetes and hypertension remission in the general obese population...
June 2018: Current Heart Failure Reports
https://www.readbyqxmd.com/read/29623530/novel-insights-and-treatment-strategies-for-right-heart-failure
#20
REVIEW
Weiqin Lin, Ai-Ling Poh, W H Wilson Tang
PURPOSE OF REVIEW: The function of the right ventricle (RV) is intimately linked to its preload (systemic volume status) and afterload (pulmonary vasculature). In this review, we explore current knowledge in RV physiology, RV function assessment, causes of right heart failure (RHF), and specific treatment strategies for RHF. RECENT FINDINGS: We examine the evidence behind new pharmacological therapies available, such as macitentan and riociguat in the treatment of specific etiologies of RHF...
June 2018: Current Heart Failure Reports
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