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Toxicology International

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https://www.readbyqxmd.com/read/26862284/an-unusual-case-of-triazophos-poisoning-presenting-with-new-onset-refractory-status-epilepticus
#1
Sourya Acharya, Samarth Shukla, Vipul Malpani
No abstract text is available yet for this article.
January 2015: Toxicology International
https://www.readbyqxmd.com/read/26862283/eucalyptus-oil-poisoning
#2
K Jagadish Kumar, Sandeep Sonnathi, C Anitha, M Santhoshkumar
No abstract text is available yet for this article.
January 2015: Toxicology International
https://www.readbyqxmd.com/read/26862282/an-unsuspected-pharmacological-vitamin-d-toxicity-in-a-child-and-its-brief-review-of-literature
#3
Manju Nimesh, Pritish Singh, Urmila Jhamb, A P Dubey
Inordinate administration of Vitamin D beyond required doses and duration occurs as a sporadic event among frequent empirical therapies of pharmacological Vitamin D. Such instances lead to Vitamin D intoxication. Systemic hypertension is an unsuspected after-effect of Vitamin D toxicity in a child unlike other toxicity effects such as hypercalcemia, neurological deterioration, etc., Here, we report a case of a 1-year-old child who developed acute hypertension and severe hypercalcemia due to Vitamin D toxicity which was masked by initial dehydration such as illness and brief review of literature about clinical entity...
January 2015: Toxicology International
https://www.readbyqxmd.com/read/26862281/fipronil-compound-consumption-presenting-as-status-epilepticus
#4
M Y Bharathraj, K Venugopal, Kadappa Jaligidad, Halli Karibasappa, Hemantha Kumar
Fipronil is a broadspectrum N-phenylpyrazole insecticide with gamma-aminobutyric acid type A receptor inhibitory action causing hyperexcitability of central nervous system. There is no literature reported in the past concerning its acute toxicity in human beings. A case report is useful for workers in medical and veterinary field. Hence, we are reporting a case in which young male intoxicated with fipronil compound was presented to the emergency department for having generalized tonic-clonic seizures and subsequently with the features of delirium for few days...
January 2015: Toxicology International
https://www.readbyqxmd.com/read/26862280/bilateral-eyelid-ptosis-attributed-to-vincristine-treated-successfully-with-pyridoxine-and-thiamine-in-a-child-with-acute-lymphoblastic-leukemia
#5
Emmanuel Hatzipantelis, Ioannis Kyriakidis, Evangelos Pavlou, Efterpi Pavlidou
Vincristine-induced neurotoxicity is an adverse effect commonly seen in pediatric patients treated for cancer. We hereby present a case of a 6-year-old boy with acute lymphoblastic leukemia, who developed bilateral eyelid ptosis 25 days after the last intravenous administration of vincristine (cumulative dose 14.2 mg i.e., 17.75 mg/m(2)). The boy was treated with 5 mg/kg thiamine and with 10 mg/kg pyridoxine. Complete recovery of ptosis was noticed 4 weeks after the initiation of Vitamins B1 and B6 supplementation therapy...
January 2015: Toxicology International
https://www.readbyqxmd.com/read/26862279/psychosis-as-harbinger-of-phenytoin-toxicity
#6
Manish Borasi, R Pravin Verma, Sumit Kumar Gupta
Psychosis with phenytoin use has earlier been reported only in the context of Vitamin B12 or folic acid deficiency. We report a rare case of phenytoin toxicity manifesting as psychosis in the absence of Vitamin deficiency. The importance of recognition of psychosis as a harbinger of phenytoin toxicity and implications for management are discussed.
January 2015: Toxicology International
https://www.readbyqxmd.com/read/26862278/a-case-of-trientine-overdose
#7
Ahmed Hashim, Nick Parnell
Wilson disease is a rare genetic hepatic and neurological disorder of copper accumulation. Trientine is usually used as a second line in the management of patients with this condition. We present a case of a large overdose of Trientine (60 g) resulting in self-limiting dizziness and vomiting with no further clinical sequelae or significant biochemical abnormalities. This case shows that Trientine has a good safety profile and hence could be used as a first line treatment in patients with Wilson's disease who suffer from psychiatric complications and who might be at risk of self-harm...
January 2015: Toxicology International
https://www.readbyqxmd.com/read/26862277/food-color-induced-hepatotoxicity-in-swiss-albino-rats-rattus-norvegicus
#8
Beenam Saxena, Shiv Sharma
OBJECTIVE: Certain dietary constituents can induce toxicity and play a critical role in the development of several hepatic disorders. Tartrazine, metanil yellow and sunset yellow are widely used azo dyes in food products, so the present study is aimed to investigate the food color induced hepatotoxicity in Swiss albino rats. MATERIALS AND METHODS: Swiss albino rats were divided into four groups, each group having six animals. Group I served as control, Group II, Group III and Group IV were administered with 25, 50 and 75 mg/kg body weight blend of sunset yellow, metanil yellow and tartrazine for 30 days...
January 2015: Toxicology International
https://www.readbyqxmd.com/read/26862276/alterations-in-hematological-profile-of-experimentally-induced-subchronic-thiacloprid-toxicosis-in-gallus-domesticus
#9
Saloni Singla, Harpal Singh Sandhu
OBJECTIVES: Thiacloprid, a novel neonicotinoid insecticide is chiefly used as a crop protectant therefore it is likely to cause indirect exposure to poultry through contaminated feed and water because this species is occasionally supplied with feed that is, declared unfit for human consumption. The current study was performed to explore the nonlethal toxic effects of thiacloprid in Gallus domesticus on hematological parameters. MATERIALS AND METHODS: Fifty-two birds were randomly divided into nine groups...
January 2015: Toxicology International
https://www.readbyqxmd.com/read/26862275/anti-arthritic-activity-of-dashanga-ghana-an-ayurvedic-compound-formulation-against-freund-s-adjuvant-induced-arthritis-in-charles-foster-albino-rats
#10
Galib Ruknuddin, B J Patgiri, P K Prajapati, B K Ashok, B Ravishankar
INTRODUCTION: Arthritis is the most common cause of disability, limiting the activities of adults throughout the world. Apart from the conventional treatment strategies using non-steroidal anti-inflammatory drugs, disease-modifying anti-rheumatic drugs, and glucocorticoids, newer and safer drugs are continuously being searched, as long-term usage of these drugs have resulted in adverse effects. Besides this, currently a number of medicinal plants are under scientific evaluation to develop a promising remedy in these cases...
January 2015: Toxicology International
https://www.readbyqxmd.com/read/26862274/modulating-effect-of-enicostemma-littorale-on-the-expression-pattern-of-apoptotic-cell-proliferative-inflammatory-and-angiogenic-markers-during-7-12-dimethylbenz-a-anthracene-induced-hamster-buccal-pouch-carcinogenesis
#11
Shanmugam Manoharan, Duraisamy Rajasekaran, Murugaraj Manoj Prabhakar, Sekar Karthikeyan, Asokan Manimaran
Enicostemma littorale leaves are traditionally used for the treatment of several diseases, including inflammation and cancer. This study has taken effort to explore the antitumor initiating potential of E. littorale leaves (ElELet) by analyzing the expression pattern of apoptotic (p53, Bcl-2 and Bcl-2 associated X-protein), cell-proliferative (cyclin D1 and proliferating cell nuclear antigen), angiogenic (vascular endothelial growth factor), invasive (matrix metalloproteinase-2 and 9), and inflammatory (NF-κB and cyclooxygenase-2) markers during 7, 12-dimethylbenz (a) anthracene (DMBA) induced hamster buccal pouch carcinogenesis...
January 2015: Toxicology International
https://www.readbyqxmd.com/read/26862273/detection-of-malathion-resistance-in-hyalomma-anatolicum-anatolicum-from-bathinda-district-punjab
#12
Jyoti, Nirbhay Kumar Singh, Mranalini Prerna, Harkirat Singh, S S Rath
OBJECTIVE: The resistance status against malathion in Hyalomma anatolicum anatolicum ticks collected from Bathinda district, Punjab, was evaluated by adult immersion test (AIT). MATERIALS AND METHODS: Technical grade malathion was used for conduction of AIT with 2 min immersion time protocol. The regression graph of probit mortality of ticks was plotted against log values of increasing concentrations of malathion and was utilized for the determination of slope of mortality, LC50, LC95 (95% confidence interval [CI]) and resistance factor (RF)...
January 2015: Toxicology International
https://www.readbyqxmd.com/read/26862272/a-three-generation-study-with-effect-of-imidacloprid-in-rats-biochemical-and-histopathological-investigation
#13
Prerna Vohra, Kuldeep Singh Khera
OBJECTIVES: This study was designed to evaluate the dose-dependent toxic effects of imidacloprid on the female ratsthat were treated through three generations (F0, F1, and F2). F2 female rats were sacrificed at the end of the experiment to see the long-term effect of imidacloprid. MATERIALS AND METHODS: Rats were divided into three groups of 6 each. Group I served as control. Group II served as treated I and given 1/45(th) LD50 (10 mg/kg/day) of imidacloprid. Group III served as treated II and given 1/22(th) LD50 (20 mg/kg/day) of imidacloprid...
January 2015: Toxicology International
https://www.readbyqxmd.com/read/26862271/assessment-of-anticarcinogenic-potential-of-vitex-trifolia-and-triticum-aestivum-linn-by-in-vitro-rat-liver-microsomal-degranulation
#14
Marimuthu Mathankumar, Ramasamy Tamizhselvi, Venkatraman Manickam, Gaurav Purohit
OBJECTIVE: The main objective of this preliminary study is to confirm the synergistic anticarcinogenic potential of Vitex trifolia and Triticum aestivum ethanolic extracts. MATERIALS AND METHODS: Rat hepatic microsomal degranulation is a short - term technique that has been used for the detection of potential chemical carcinogens, in vitro. The present study has been carried out to study the inhibition of ribosome- membrane disruption against 3, 8-Diamino-5-ethyl-6-pheylphenanthridinium bromide (EB), as the degranulating agent, by measuring the RNA/protein ratios of microsomal membranes in the presence or absence of V...
January 2015: Toxicology International
https://www.readbyqxmd.com/read/26862270/effect-of-repeated-administration-of-cefquinome-on-biochemical-and-hematological-parameters-in-buffalo-calves
#15
Mukesh Mangal, Suresh Kumar Sharma
AIM: Cefquinome, a fourth generation of cephalosporins have been developed for use in animals. Similar to other species, it may also have some adverse reactions in buffalo calves at therapeutic dosage. In the present study, effect of repeated administration of cefquinome on biochemical and hematological parameters was studied in buffalo calves. MATERIALS AND METHODS: Animals were divided into two groups having three animals in each group. Group 1 was kept as control and animals of Group 2 were given cefquinome at dose rate of 2 mg...
January 2015: Toxicology International
https://www.readbyqxmd.com/read/26862269/a-multidisciplinary-approach-with-hyperbaric-oxygen-therapy-improve-outcome-in-snake-bite-injuries
#16
Pradeoth Mukundan Korambayil, Prashanth Varkey Ambookan, Siju Varghese Abraham, Ajay Ambalakat
AIM: Snakebite injuries are common in tropical India among those who are involved in outdoor activities. These injuries results in cellulitis, gangrene at the bite area, bleeding manifestations, compartment syndrome, regional lymphadenopathy, septicemia, hypotension, and disseminated intravascular coagulation (DIC) resulting in significant morbidity and mortality. The purpose of this study is to share our experience of multidisciplinary approach in the management of snakebite injuries of the extremities with various treatment modalities including hyperbaric oxygen (HBO) therapy, surgical debridement, and soft tissue reconstruction to provide an effective treatment for snake bite injuries...
January 2015: Toxicology International
https://www.readbyqxmd.com/read/26862268/effect-of-cypermethrin-on-the-growth-of-ciliate-protozoan-paramecium-caudatum
#17
Joydeep Dutta
OBJECTIVE: The objective of this study is to assess the effect of cypermethrin on the growth of ciliate protozoan Paramecium caudatum. MATERIALS AND METHODS: Monoxenic culture of P. caudatum, were exposed to different doses (0.01, 0.05, 0.1, 0.15, and 0.2 µg/L) of cypermethrin along with control for 24, 48, 72, and 96 h time interval. The total numbers of live and dead cells were counted after trypan blue staining in Neubauer hemocytometer. RESULTS: Marked decrease in the number of living cells with the increase in the concentration of cypermethrin and with increasing exposure time intervals was recorded...
January 2015: Toxicology International
https://www.readbyqxmd.com/read/26862267/protective-effects-of-propofol-against-methamphetamine-induced-neurotoxicity
#18
Mohammad Shokrzadeh, Ehsan Zamani, Mona Mehrzad, Yazdan Norian, Fatemeh Shaki
CONTEXT: Methamphetamine (METH) is widely abused in worldwide. METH use could damage the dopaminergic system and induce neurotoxicity via oxidative stress and mitochondrial dysfunction. Propofol, a sedative-hypnotic agent, is known for its antioxidant properties. In this study, we used propofol for attenuating of METH-induced neurotoxicity in rats. SUBJECTS AND METHODS: We used Wistar rats that the groups (six rats each group) were as follows: Control, METH (5 mg/kg IP), and propofol (5, 10 and 20 mg/kg, IP) was administered 30 min before METH...
January 2015: Toxicology International
https://www.readbyqxmd.com/read/26862266/dose-dependent-effect-of-iso-octane-on-hacat-a-model-study
#19
Lopamudra Das, Soumen Das, Jyotirmoy Chatterjee
OBJECTIVE: Improved understanding of cytotoxicity under chemical assaults may be achieved by multimodal analysis of cellular morphology, viability, molecular expressions, and biophysical properties. MATERIALS AND METHODS: In this study dose-dependent effects of an organic solvent (OS), iso-octane (IO), known to cause skin irritation, has been explored multimodally for understanding its effect on structural and functional profile of normal epithelial cell population in vitro...
January 2015: Toxicology International
https://www.readbyqxmd.com/read/26862265/clinico-epidemiological-profile-of-snake-bites-over-6-year-period-from-a-rural-secondary-care-centre-of-northern-india-a-descriptive-study
#20
Shubhanker Mitra, Abhinav Agarwal, B U Shubhankar, Sahil Masih, Viswajit Krothapalli, Brian Mark Lee, Jeevan Kuruvilla, Reginald Alex
Estimated deaths due to snake bites are more than 46,000 annually in India. Ninety-seven percent bites occur in rural areas. Data on snake bites from Jharkhand rural area are sparse. This study describes 6 years profile of snake bite patients from January, 2007 to December, 2012 at Nav Jivan Hospital in Palamu district, Jharkhand.
January 2015: Toxicology International
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