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Journal of Translational Medicine

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https://www.readbyqxmd.com/read/29233191/mkrmda-multiple-kernel-learning-based-kronecker-regularized-least-squares-for-mirna-disease-association-prediction
#1
Xing Chen, Ya-Wei Niu, Guang-Hui Wang, Gui-Ying Yan
BACKGROUND: Recently, as the research of microRNA (miRNA) continues, there are plenty of experimental evidences indicating that miRNA could be associated with various human complex diseases development and progression. Hence, it is necessary and urgent to pay more attentions to the relevant study of predicting diseases associated miRNAs, which may be helpful for effective prevention, diagnosis and treatment of human diseases. Especially, constructing computational methods to predict potential miRNA-disease associations is worthy of more studies because of the feasibility and effectivity...
December 12, 2017: Journal of Translational Medicine
https://www.readbyqxmd.com/read/29233174/sprifermin-rhfgf18-modulates-extracellular-matrix-turnover-in-cartilage-explants-ex-vivo
#2
Ditte Reker, Cecilie F Kjelgaard-Petersen, Anne Sofie Siebuhr, Martin Michaelis, Anne Gigout, Morten A Karsdal, Christoph Ladel, Anne C Bay-Jensen
BACKGROUND: Sprifermin (recombinant human fibroblast growth factor 18) is in clinical development as a potential disease-modifying osteoarthritis drug (DMOAD). In vitro studies have shown that cartilage regenerative properties of sprifermin involve chondrocyte proliferation and extracellular matrix (ECM) production. To gain further insight into the process of sprifermin in the cartilage tissue, this study aimed at investigating the ECM turnover of articular cartilage explants in a longitudinal manner...
December 12, 2017: Journal of Translational Medicine
https://www.readbyqxmd.com/read/29228965/genetic-polymorphism-in-atg16l1-gene-is-associated-with-adalimumab-use-in-inflammatory-bowel-disease
#3
V J A A Nuij, M P Peppelenbosch, C J van der Woude, G M Fuhler
BACKGROUND: The role of single nucleotide polymorphisms (SNPs) associated with inflammatory bowel disease (IBD) is gaining interest. With the advent of novel therapies, personalized treatment in IBD is a future goal. We wondered whether IBD-associated SNPs are able to predict response to anti-TNFα treatment. METHODS: Data on treatment use and primary response, loss of response and side effects to anti-TNFα treatments were retrieved for 570 IBD patients. rs13361189 (IRGM), rs10210302 (ATG16L1), rs2066844, rs2066845, rs2066847 (NOD2), rs35873774 (XBP1), rs11175593 (LRRK2), rs11465804 (IL23R), rs2301436 (CCR6), rs744166 (STAT3) and rs4821544 (NCF4) SNP status were determined...
December 11, 2017: Journal of Translational Medicine
https://www.readbyqxmd.com/read/29228964/effects-of-a-multi-strain-probiotic-supplement-for-12%C3%A2-weeks-in-circulating-endotoxin-levels-and-cardiometabolic-profiles-of-medication-na%C3%A3-ve-t2dm-patients-a-randomized-clinical-trial
#4
Shaun Sabico, Ayah Al-Mashharawi, Nasser M Al-Daghri, Sobhy Yakout, Abdullah M Alnaami, Majed S Alokail, Philip G McTernan
BACKGROUND: The present randomized clinical trial characterized the beneficial effects of a multi-strain probiotics supplementation on improving circulating endotoxin levels (primary endpoint) and other cardiometabolic biomarkers (secondary endpoint) in patients with T2DM. METHODS: A total of 78 adult Saudi T2DM patients (naïve and without co-morbidities) participated in this clinical trial and were randomized to receive twice daily placebo or probiotics [(2.5 × 109 cfu/g) containing the following bacterial strains: Bifidobacterium bifidum W23, Bifidobacterium lactis W52, Lactobacillus acidophilus W37, Lactobacillus brevis W63, Lactobacillus casei W56, Lactobacillus salivarius W24, Lactococcus lactis W19 and Lactococcus lactis W58 (Ecologic®Barrier)] in a double-blind manner for 12 weeks...
December 11, 2017: Journal of Translational Medicine
https://www.readbyqxmd.com/read/29228957/evaluation-of-the-effect-of-d-amino-acid-incorporation-into-amyloid-reactive-peptides
#5
Emily B Martin, Angela Williams, Tina Richey, Craig Wooliver, Alan Stuckey, James S Foster, Stephen J Kennel, Jonathan S Wall
BACKGROUND: Systemic amyloidoses comprise diseases characterized by the deposition of proteinaceous material known as amyloid. Currently, without performing multiple biopsies, there is no way to ascertain the extent of amyloid deposition in patients-a critical piece of information that informs prognosis and therapeutic strategies. We have developed pan-amyloid-targeting peptides for imaging amyloid and recently have adapted these for use as pre-targeting agents in conjunction with immunotherapy...
December 11, 2017: Journal of Translational Medicine
https://www.readbyqxmd.com/read/29221448/next-generation-sequencing-recent-applications-to-the-analysis-of-colorectal-cancer
#6
REVIEW
Filippo Del Vecchio, Valentina Mastroiaco, Antinisca Di Marco, Chiara Compagnoni, Daria Capece, Francesca Zazzeroni, Carlo Capalbo, Edoardo Alesse, Alessandra Tessitore
Since the establishment of the Sanger sequencing method, scientists around the world focused their efforts to progress in the field to produce the utmost technology. The introduction of next-generation sequencing (NGS) represents a revolutionary step and promises to lead to massive improvements in our understanding on the role of nucleic acids functions. Cancer research began to use this innovative and highly performing method, and interesting results started to appear in colorectal cancer (CRC) analysis. Several studies produced high-quality data in terms of mutation discovery, especially about actionable or less frequently mutated genes, epigenetics, transcriptomics...
December 8, 2017: Journal of Translational Medicine
https://www.readbyqxmd.com/read/29202855/soluble-cd73-as-biomarker-in-patients-with-metastatic-melanoma-patients-treated-with-nivolumab
#7
Silvana Morello, Mariaelena Capone, Claudia Sorrentino, Diana Giannarelli, Gabriele Madonna, Domenico Mallardo, Antonio M Grimaldi, Aldo Pinto, Paolo Antonio Ascierto
BACKGROUND: Nivolumab is an anti-PD1 checkpoint inhibitor active in patients with advanced melanoma and as adjuvant therapy in high-risk metastatic melanoma patients. METHODS: In this single-center retrospective analysis, we investigated the CD73 enzyme activity in patients with metastatic melanoma stage IV and its correlation with the response to nivolumab. The soluble CD73 (sCD73) enzyme activity was measured in the serum of 37 melanoma patients before receiving nivolumab and the Harrel's C index was used to find the best cut-off for this biomarker...
December 4, 2017: Journal of Translational Medicine
https://www.readbyqxmd.com/read/29202780/transforming-growth-factor-beta-tgf-%C3%AE-in-adolescent-chronic-fatigue-syndrome
#8
Vegard Bruun Wyller, Chinh Bkrong Nguyen, Judith Anita Ludviksen, Tom Eirik Mollnes
BACKGROUND: Chronic fatigue syndrome (CFS) is a prevalent and disabling condition among adolescent. The disease mechanisms are unknown. Previous studies have suggested elevated plasma levels of several cytokines, but a recent meta-analysis of 38 articles found that of 77 different cytokines measured in plasma, transforming growth factor beta (TGF-β) was the only one that was elevated in patients compared to controls in a sufficient number of articles. In the present study we therefore compared the plasma levels of the three TGF-β isoforms in adolescent CFS patients and healthy controls...
December 4, 2017: Journal of Translational Medicine
https://www.readbyqxmd.com/read/29202777/identification-of-coexistence-of-braf-v600e-mutation-and-ezh2-gain-specifically-in-melanoma-as-a-promising-target-for-combination-therapy
#9
Huan Yu, Meng Ma, Junya Yan, Longwen Xu, Jiayi Yu, Jie Dai, Tianxiao Xu, Huan Tang, Xiaowen Wu, Siming Li, Bin Lian, Lili Mao, Zhihong Chi, Chuanliang Cui, Jun Guo, Yan Kong
BACKGROUND: Coexistence of enhancer of zeste homolog 2 (EZH2) and BRAF gene aberrations has been described in many cancer types. In this study, we aim to explore the coexistence status of BRAF V600E mutation and the copy number variation of EZH2 and explore the potential of this combination as a therapeutic target. METHODS: A total of 138 cases of melanoma samples harboring BRAF V600E mutation were included, and EZH2 copy numbers were examined by QuantiGenePlex DNA Assays...
December 4, 2017: Journal of Translational Medicine
https://www.readbyqxmd.com/read/29197390/evaluation-of-b1-inhomogeneity-effect-on-dce-mri-data-analysis-of-brain-tumor-patients-at-3t
#10
Anirban Sengupta, Rakesh Kumar Gupta, Anup Singh
BACKGROUND: Dynamic-contrast-enhanced (DCE) MRI data acquired using gradient echo based sequences is affected by errors in flip angle (FA) due to transmit B1 inhomogeneity (B1inh). The purpose of the study was to evaluate the effect of B1inh on quantitative analysis of DCE-MRI data of human brain tumor patients and to evaluate the clinical significance of B1inh correction of perfusion parameters (PPs) on tumor grading. METHODS: An MRI study was conducted on 35 glioma patients at 3T...
December 2, 2017: Journal of Translational Medicine
https://www.readbyqxmd.com/read/29183386/application-of-survival-tree-analysis-for-exploration-of-potential-interactions-between-predictors-of-incident-chronic-kidney-disease-a-15-year-follow-up-study
#11
Azra Ramezankhani, Maryam Tohidi, Fereidoun Azizi, Farzad Hadaegh
BACKGROUND: Chronic kidney disease (CKD) is a growing public health challenges worldwide. Various studies have investigated risk factors of incident CKD; however, a very few studies examined interaction between these risk factors. In an attempt to clarify the potential interactions between risk factors of CKD, we performed survival tree analysis. METHODS: A total of 8238 participants (46.1% men) aged > 20 years without CKD at baseline [(1999-2001) and (2002-2005)], were followed until 2014...
November 28, 2017: Journal of Translational Medicine
https://www.readbyqxmd.com/read/29183378/vascular-abnormalities-and-development-of-hypoxia-in-microscopic-melanoma-xenografts
#12
Jon-Vidar Gaustad, Trude G Simonsen, Lise Mari K Andersen, Einar K Rofstad
BACKGROUND: Studies investigating the oxygenation status and the development of hypoxia in microscopic tumors are sparse. The purpose of this study was to measure the extent of hypoxia in microscopic melanoma xenografts and to search for possible mechanisms leading to the development of hypoxia in these tumors. METHODS: A-07, D-12, R-18, and U-25 human melanoma xenografts grown in dorsal window chambers or as flank tumors were used as preclinical tumor models. Morphologic and functional parameters of vascular networks were assessed with intravital microscopy, and the expression of angiogenesis-related genes was assessed with quantitative PCR...
November 28, 2017: Journal of Translational Medicine
https://www.readbyqxmd.com/read/29178939/autocrine-parathyroid-hormone-like-hormone-promotes-intrahepatic-cholangiocarcinoma-cell-proliferation-via-increased-erk-jnk-atf2-cyclind1-signaling
#13
Jing Tang, Yan Liao, Shuying He, Jie Shi, Liang Peng, Xiaoping Xu, Fang Xie, Na Diao, Jinlan Huang, Qian Xie, Chuang Lin, Xiaoying Luo, Kaili Liao, Juanjuan Ma, Jingyi Li, Daichao Zhou, Zhijun Li, Jun Xu, Chao Zhong, Guozhen Wang, Lan Bai
BACKGROUND AND AIMS: Intrahepatic cholangiocarcinoma (ICC) is an aggressive tumor with a high fatality rate. It was recently found that parathyroid hormone-like hormone (PTHLH) was frequently overexpressed in ICC compared with non-tumor tissue. This study aimed to elucidate the underlying mechanisms of PTHLH in ICC development. METHODS: The CCK-8 assay, colony formation assays, flow cytometry and a xenograft model were used to examine the role of PTHLH in ICC cells proliferation...
November 25, 2017: Journal of Translational Medicine
https://www.readbyqxmd.com/read/29178890/cytokine-and-autoantibody-clusters-interaction-in-systemic-lupus-erythematosus
#14
Yovana Pacheco, Julián Barahona-Correa, Diana M Monsalve, Yeny Acosta-Ampudia, Manuel Rojas, Yhojan Rodríguez, Juliana Saavedra, Mónica Rodríguez-Jiménez, Rubén D Mantilla, Carolina Ramírez-Santana, Nicolás Molano-González, Juan-Manuel Anaya
BACKGROUND: Evidence supports the existence of different subphenotypes in systemic lupus erythematosus (SLE) and the pivotal role of cytokines and autoantibodies, which interact in a highly complex network. Thus, understanding how these complex nonlinear processes are connected and observed in real-life settings is a major challenge. Cluster approaches may assist in the identification of these subphenotypes, which represent such a phenomenon, and may contribute to the development of personalized medicine...
November 25, 2017: Journal of Translational Medicine
https://www.readbyqxmd.com/read/29162103/phenolic-compounds-apigenin-hesperidin-and-kaempferol-reduce-in-vitro-lipid-accumulation-in-human-adipocytes
#15
Saioa Gómez-Zorita, Arrate Lasa, Naiara Abendaño, Alfredo Fernández-Quintela, Andrea Mosqueda-Solís, Maria Pilar Garcia-Sobreviela, Jose M Arbonés-Mainar, Maria P Portillo
BACKGROUND: Adipocytes derived from human mesenchymal stem cells (MSCs) are widely used to investigate adipogenesis. Taking into account both the novelty of these MSCs and the scarcity of studies focused on the effects of phenolic compounds, the aim of the present study was to analyze the effect of apigenin, hesperidin and kaempferol on pre-adipocyte and mature adipocytes derived from this type of cells. In addition, the expression of genes involved in TG accumulation was also measured...
November 21, 2017: Journal of Translational Medicine
https://www.readbyqxmd.com/read/29145885/future-perspectives-in-melanoma-research-melanoma-bridge-napoli-november-30th-3rd-december-2016
#16
Paolo A Ascierto, Sanjiv S Agarwala, Gennaro Ciliberto, Sandra Demaria, Reinhard Dummer, Connie P M Duong, Soldano Ferrone, Silvia C Formenti, Claus Garbe, Ruth Halaban, Samir Khleif, Jason J Luke, Lluis M Mir, Willem W Overwijk, Michael Postow, Igor Puzanov, Paul Sondel, Janis M Taube, Per Thor Straten, David F Stroncek, Jennifer A Wargo, Hassane Zarour, Magdalena Thurin
Major advances have been made in the treatment of cancer with targeted therapy and immunotherapy; several FDA-approved agents with associated improvement of 1-year survival rates became available for stage IV melanoma patients. Before 2010, the 1-year survival were quite low, at 30%; in 2011, the rise to nearly 50% in the setting of treatment with Ipilimumab, and rise to 70% with BRAF inhibitor monotherapy in 2013 was observed. Even more impressive are 1-year survival rates considering combination strategies with both targeted therapy and immunotherapy, now exceeding 80%...
November 16, 2017: Journal of Translational Medicine
https://www.readbyqxmd.com/read/29141648/polymorphisms-at-microrna-binding-sites-of-ara-c-and-anthracyclines-metabolic-pathway-genes-are-associated-with-outcome-of-acute-myeloid-leukemia-patients
#17
Hai-Xia Cao, Chao-Feng Miao, Liang Yan, Ping Tang, Li-Rong Zhang, Ling Sun
BACKGROUND: Gene polymorphisms at microRNA-binding sites (poly-miRTS) may affect gene transcription and expression through miRNA regulation, which is associated with cancer susceptibility, sensitivity to chemotherapy and prognosis. This study investigated the association between poly-miRTS of Ara-C/anthracycline metabolic pathways genes and the outcome of acute myeloid leukemia (AML) in Chinese patients after Ara-C-based chemotherapy. METHODS: A total of 17 poly-miRTS were selected from the SNPinfo Web Server and genotyped in 206 Chinese Han non-FAB-M3 AML patients using the SEQUENOM Mass-ARRAY system...
November 15, 2017: Journal of Translational Medicine
https://www.readbyqxmd.com/read/29126450/the-macrophage-c-type-lectin-receptor-clec5a-mdl-1-expression-is-associated-with-early-plaque-progression-and-promotes-macrophage-survival
#18
Weixin Xiong, Haibo Wang, Lin Lu, Rui Xi, Fang Wang, Gang Gu, Rong Tao
BACKGROUND: Biomarkers of early plaque progression are still elusive. Myeloid DAP12-associating lectin-1 (MDL-1), also called CLEC5A, is a C-type lectin receptor implicated in the progression of multiple acute and chronic inflammatory diseases. However, the relationship between its level and atherosclerosis is unknown. In this study, we aimed to investigate the correlation between macrophage MDL-1 expression and early atherosclerosis progression. METHODS: Immunofluorescence staining, real-time PCR and western blot were performed to analyze MDL-1 expression in aorta or mice macrophages...
November 10, 2017: Journal of Translational Medicine
https://www.readbyqxmd.com/read/29126427/a-murine-model-for-developmental-dysplasia-of-the-hip-ablation-of-cx3cr1-affects-acetabular-morphology-and-gait
#19
George Feldman, Arlene Offemaria, Hind Sawan, Javad Parvizi, Theresa A Freeman
BACKGROUND: Developmental dysplasia of the hip (DDH) is a debilitating condition whose distinguishing signs include incomplete formation of the acetabulum leading to dislocation of the femur, accelerated wear of the articular cartilage and joint laxity resulting in osteoarthritis. It is a complex disorder having environmental and genetic causes. Existing techniques fail to detect milder forms of DDH in newborns leading to hip osteoarthritis in young adults. A sensitive, specific and cost effective test would allow identification of newborns that could be non-invasively corrected by the use of a Pavlik harness...
November 10, 2017: Journal of Translational Medicine
https://www.readbyqxmd.com/read/29121966/radioprotective-agents-to-prevent-cellular-damage-due-to-ionizing-radiation
#20
REVIEW
Tyler A Smith, Daniel R Kirkpatrick, Sean Smith, Trevor K Smith, Tate Pearson, Aparna Kailasam, Kortney Z Herrmann, Johanna Schubert, Devendra K Agrawal
Medical imaging has become a central component of patient care to ensure early and accurate diagnosis. Unfortunately, many imaging modalities use ionizing radiation to generate images. Ionizing radiation even in low doses can cause direct DNA damage and generate reactive oxygen species and free radicals, leading to DNA, protein, and lipid membrane damage. This cell damage can lead to apoptosis, necrosis, teratogenesis, or carcinogenesis. As many as 2% of cancers (and an associated 15,000 deaths annually) can be linked to computed tomography exposure alone...
November 9, 2017: Journal of Translational Medicine
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