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BMC Medicine

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https://www.readbyqxmd.com/read/29137630/diet-net-best-practice-guidelines-for-dietary-assessment-in-health-research
#1
Janet E Cade, Marisol Warthon-Medina, Salwa Albar, Nisreen A Alwan, Andrew Ness, Mark Roe, Petra A Wark, Katharine Greathead, Victoria J Burley, Paul Finglas, Laura Johnson, Polly Page, Katharine Roberts, Toni Steer, Jozef Hooson, Darren C Greenwood, Sian Robinson
BACKGROUND: Dietary assessment is complex, and strategies to select the most appropriate dietary assessment tool (DAT) in epidemiological research are needed. The DIETary Assessment Tool NETwork (DIET@NET) aimed to establish expert consensus on Best Practice Guidelines (BPGs) for dietary assessment using self-report. METHODS: The BPGs were developed using the Delphi technique. Two Delphi rounds were conducted. A total of 131 experts were invited, and of these 65 accepted, with 48 completing Delphi round I and 51 completing Delphi round II...
November 15, 2017: BMC Medicine
https://www.readbyqxmd.com/read/29129186/an-exploration-of-mortality-risk-factors-in-non-severe-pneumonia-in-children-using-clinical-data-from-kenya
#2
Timothy Tuti, Ambrose Agweyu, Paul Mwaniki, Niels Peek, Mike English
BACKGROUND: Childhood pneumonia is the leading infectious cause of mortality in children younger than 5 years old. Recent updates to World Health Organization pneumonia guidelines recommend outpatient care for a population of children previously classified as high risk. This revision has been challenged by policymakers in Africa, where mortality related to pneumonia is higher than in other regions and often complicated by comorbidities. This study aimed to identify factors that best discriminate inpatient mortality risk in non-severe pneumonia and explore whether these factors offer any added benefit over the current criteria used to identify children with pneumonia requiring inpatient care...
November 13, 2017: BMC Medicine
https://www.readbyqxmd.com/read/29121925/advances-and-challenges-in-cirrhosis-and-portal-hypertension
#3
Annalisa Berzigotti
BACKGROUND: Liver cirrhosis is the fourth cause of death in adults in Western countries, with complications of portal hypertension being responsible for most casualties. In order to reduce mortality, development of accurate diagnostic methods for early diagnosis, effective etiologic treatment, improved pharmacological therapy for portal hypertension, and effective therapies for end-stage liver failure are required. DISCUSSION: Early detection of cirrhosis and portal hypertension is now possible using simple non-invasive methods, leading to the advancement of individualized risk stratification in clinical practice...
November 10, 2017: BMC Medicine
https://www.readbyqxmd.com/read/29115947/fluctuations-in-the-incidence-of-type-1-diabetes-in-the-united-states-from-2001-to-2015-a-longitudinal-study
#4
Mary A M Rogers, Catherine Kim, Tanima Banerjee, Joyce M Lee
BACKGROUND: While the United States has the largest number of children with type 1 diabetes mellitus, less is known regarding adult-onset disease. The present study utilizes nationwide data to compare the incidence of type 1 diabetes in youth (0-19 years) to that of adults (20-64 years). METHODS: In this longitudinal study, the Clinformatics® Data Mart Database was used, which contains information from 61 million commercially insured Americans (years 2001-2015)...
November 8, 2017: BMC Medicine
https://www.readbyqxmd.com/read/29110650/group-based-developmental-bmi-trajectories-polycystic-ovary-syndrome-and-gestational-diabetes-a-community-based-longitudinal-study
#5
Nadira Sultana Kakoly, Arul Earnest, Lisa J Moran, Helena J Teede, Anju E Joham
BACKGROUND: Obesity is common in young women, increasing insulin resistance (IR) and worsening pregnancy complications, including gestational diabetes (GDM). Women with polycystic ovary syndrome (PCOS) are commonly obese, which aggravates the severity of PCOS clinical expression. Relationships between these common insulin-resistant conditions, however, remain unclear. METHODS: We conducted a secondary analysis of the Australian Longitudinal Study on Women's Health (ALSWH) database, including data from 8009 women aged 18-36 years across six surveys...
November 6, 2017: BMC Medicine
https://www.readbyqxmd.com/read/29096631/prediction-of-uncomplicated-pregnancies-in-obese-women-a-prospective-multicentre-study
#6
Matias C Vieira, Sara L White, Nashita Patel, Paul T Seed, Annette L Briley, Jane Sandall, Paul Welsh, Naveed Sattar, Scott M Nelson, Debbie A Lawlor, Lucilla Poston, Dharmintra Pasupathy
BACKGROUND: All obese pregnant women are considered at equal high risk with respect to complications in pregnancy and birth, and are commonly managed through resource-intensive care pathways. However, the identification of maternal characteristics associated with normal pregnancy outcomes could assist in the management of these pregnancies. The present study aims to identify the factors associated with uncomplicated pregnancy and birth in obese women, and to assess their predictive performance...
November 3, 2017: BMC Medicine
https://www.readbyqxmd.com/read/29089034/rapid-diagnosis-of-new-and-relapse-tuberculosis-by-quantification-of-a-circulating-antigen-in-hiv-infected-adults-in-the-greater-houston-metropolitan-area
#7
Jia Fan, Hedong Zhang, Duc T Nguyen, Christopher J Lyon, Charles D Mitchell, Zhen Zhao, Edward A Graviss, Ye Hu
BACKGROUND: HIV-associated immune defects inhibit tuberculosis (TB) diagnosis, promote development of extrapulmonary TB and paucibacillary pulmonary TB cases with atypical radiographic features, and increase TB relapse rates. We therefore assessed the diagnostic performance of a novel assay that directly quantitates serum levels of the Mycobacterium tuberculosis (Mtb) virulence factor 10-kDa culture filtrate protein (CFP-10) to overcome limitations associated with detecting Mtb bacilli in sputum or tissue biopsies...
November 1, 2017: BMC Medicine
https://www.readbyqxmd.com/read/29082855/comparative-efficacy-and-safety-of-second-line-treatments-for-advanced-non-small-cell-lung-cancer-with-wild-type-or-unknown-status-for-epidermal-growth-factor-receptor-a-systematic-review-and-network-meta-analysis
#8
Perrine Créquit, Anna Chaimani, Amélie Yavchitz, Nassima Attiche, Jacques Cadranel, Ludovic Trinquart, Philippe Ravaud
BACKGROUND: Docetaxel, pemetrexed, erlotinib, and gefitinib are recommended as second-line treatment for advanced non-small cell lung cancer (NSCLC) with wild-type or unknown status for epidermal growth factor receptor (EGFR). However, the number of published randomized clinical trials (RCTs) on this topic is increasing. Our objective was to assess the comparative effectiveness and tolerability of all second-line treatments for advanced NSCLC with wild-type or unknown status for EGFR by a systematic review and network meta-analysis...
October 30, 2017: BMC Medicine
https://www.readbyqxmd.com/read/29073910/spot-sputum-samples-are-at-least-as-good-as-early-morning-samples-for-identifying-mycobacterium-tuberculosis
#9
Michael E Murphy, Patrick P J Phillips, Carl M Mendel, Emily Bongard, Anna L C Bateson, Robert Hunt, Saraswathi Murthy, Kasha P Singh, Michael Brown, Angela M Crook, Andrew J Nunn, Sarah K Meredith, Marc Lipman, Timothy D McHugh, Stephen H Gillespie
BACKGROUND: The use of early morning sputum samples (EMS) to diagnose tuberculosis (TB) can result in treatment delay given the need for the patient to return to the clinic with the EMS, increasing the chance of patients being lost during their diagnostic workup. However, there is little evidence to support the superiority of EMS over spot sputum samples. In this new analysis of the REMoxTB study, we compare the diagnostic accuracy of EMS with spot samples for identifying Mycobacterium tuberculosis pre- and post-treatment...
October 27, 2017: BMC Medicine
https://www.readbyqxmd.com/read/29065917/is-it-them-or-is-it-us-unravelling-ethnic-disparities-in-undergraduate-clinical-performance
#10
LETTER
Karen M Stegers-Jager
Given our increasingly diverse societies, there is an urgent need for research into the causes of persistent ethnic disparities in undergraduate clinical performance. It is argued that causes for underperformance can be identified from two perspectives, namely that of the students ('them') and that of the academic environment ('us'). Taking the 'us' perspective, Yeates et al. conducted a detailed experimental study aimed at understanding the processes underlying judgment and decision-making in clinical assessments...
October 25, 2017: BMC Medicine
https://www.readbyqxmd.com/read/29065875/a-randomised-trial-of-the-influence-of-racial-stereotype-bias-on-examiners-scores-feedback-and-recollections-in-undergraduate-clinical-exams
#11
Peter Yeates, Katherine Woolf, Emyr Benbow, Ben Davies, Mairhead Boohan, Kevin Eva
BACKGROUND: Asian medical students and doctors receive lower scores on average than their white counterparts in examinations in the UK and internationally (a phenomenon known as "differential attainment"). This could be due to examiner bias or to social, psychological or cultural influences on learning or performance. We investigated whether students' scores or feedback show influence of ethnicity-related bias; whether examiners unconsciously bring to mind (activate) stereotypes when judging Asian students' performance; whether activation depends on the stereotypicality of students' performances; and whether stereotypes influence examiner memories of performances...
October 25, 2017: BMC Medicine
https://www.readbyqxmd.com/read/29061126/faecal-immunochemical-tests-fit-can-help-to-rule-out-colorectal-cancer-in-patients-presenting-in-primary-care-with-lower-abdominal-symptoms-a-systematic-review-conducted-to-inform-new-nice-dg30-diagnostic-guidance
#12
Marie Westwood, Shona Lang, Nigel Armstrong, Sietze van Turenhout, Joaquín Cubiella, Lisa Stirk, Isaac Corro Ramos, Marianne Luyendijk, Remziye Zaim, Jos Kleijnen, Callum G Fraser
BACKGROUND: This study has attempted to assess the effectiveness of quantitative faecal immunochemical tests (FIT) for triage of people presenting with lower abdominal symptoms, where a referral to secondary care for investigation of suspected colorectal cancer (CRC) is being considered, particularly when the 2-week criteria are not met. METHODS: We conducted a systematic review following published guidelines for systematic reviews of diagnostic tests. Twenty-one resources were searched up until March 2016...
October 24, 2017: BMC Medicine
https://www.readbyqxmd.com/read/29052518/voluntary-stopping-of-eating-and-drinking-is-medical-support-ethically-justified
#13
Ralf J Jox, Isra Black, Gian Domenico Borasio, Johanna Anneser
BACKGROUND: Physician-assisted dying has been the subject of extensive discussion and legislative activity both in Europe and North America. In this context, dying by voluntary stopping of eating and drinking (VSED) is often proposed, and practiced, as an alternative method of self-determined dying, with medical support for VSED being regarded as ethically and legally justified. ARGUMENT: In our opinion, this view is flawed. First, we argue that VSED falls within the concept of suicide, albeit with certain unique features (non-invasiveness, initial reversibility, resemblance to the natural dying process)...
October 20, 2017: BMC Medicine
https://www.readbyqxmd.com/read/29052512/voluntarily%C3%A2-stopping-eating-and-drinking-vsed-to-hasten-death-may-clinicians-legally-support-patients-to-vsed
#14
LETTER
Thaddeus Mason Pope
Jox and colleagues recently compared and contrasted two leading end-of-life exit options, namely voluntarily stopping eating and drinking (VSED) and medical aid in dying (MAID). The authors argue that policymakers and medical societies should consider VSED and MAID in a uniform and consistent manner given that clinician participation in both constitutes assisted suicide. This is a very controversial topic. Herein, it is questioned whether there really is disparate consideration of VSED and MAID and whether it is justified, bearing in mind that VSED is not assisted suicide...
October 20, 2017: BMC Medicine
https://www.readbyqxmd.com/read/29041940/state-of-inequality-in-malaria-intervention-coverage-in-sub-saharan-african-countries
#15
Katya Galactionova, Thomas A Smith, Don de Savigny, Melissa A Penny
BACKGROUND: Scale-up of malaria interventions over the last decade have yielded a significant reduction in malaria transmission and disease burden in sub-Saharan Africa. We estimated economic gradients in the distribution of these efforts and of their impacts within and across endemic countries. METHODS: Using Demographic and Health Surveys we computed equity metrics to characterize the distribution of malaria interventions in 30 endemic countries proxying economic position with an asset-wealth index...
October 18, 2017: BMC Medicine
https://www.readbyqxmd.com/read/29032767/metabonomics-uncovers-a-reversible-proatherogenic-lipid-profile-during-infliximab-therapy-of-inflammatory-bowel-disease
#16
Jacob Tveiten Bjerrum, Casper Steenholdt, Mark Ainsworth, Ole Haagen Nielsen, Michelle Ac Reed, Karen Atkins, Ulrich Leonhard Günther, Fuhua Hao, Yulan Wang
BACKGROUND: One-third of inflammatory bowel disease (IBD) patients show no response to infliximab (IFX) induction therapy, and approximately half of patients responding become unresponsive over time. Thus, identification of potential treatment response biomarkers are of great clinical significance. This study employs spectroscopy-based metabolic profiling of serum from patients with IBD treated with IFX and healthy subjects (1) to substantiate the use of spectroscopy as a semi-invasive diagnostic tool, (2) to identify potential biomarkers of treatment response and (3) to characterise the metabolic changes during management of patients with tumour necrosis factor-α inhibitors...
October 16, 2017: BMC Medicine
https://www.readbyqxmd.com/read/29025399/plasmodium-falciparum-epcr-binding-pfemp1-expression-increases-with-malaria-disease-severity-and-is-elevated-in-retinopathy-negative-cerebral-malaria
#17
Estela Shabani, Benjamin Hanisch, Robert O Opoka, Thomas Lavstsen, Chandy C John
BACKGROUND: Expression of group A and the A-like subset of group B Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1) is associated with severe malaria (SM). The diversity of var sequences combined with the challenges of distinct classification of patient pathologies has made studying the role of distinct PfEMP1 variants on malaria disease severity challenging. The application of retinopathy in the recent years has provided a further method to clinically evaluate children with cerebral malaria (CM)...
October 13, 2017: BMC Medicine
https://www.readbyqxmd.com/read/29017491/spatial-model-for-risk-prediction-and-sub-national-prioritization-to-aid-poliovirus-eradication-in-pakistan
#18
Laina D Mercer, Rana M Safdar, Jamal Ahmed, Abdirahman Mahamud, M Muzaffar Khan, Sue Gerber, Aiden O'Leary, Mike Ryan, Frank Salet, Steve J Kroiss, Hil Lyons, Alexander Upfill-Brown, Guillaume Chabot-Couture
BACKGROUND: Pakistan is one of only three countries where poliovirus circulation remains endemic. For the Pakistan Polio Eradication Program, identifying high risk districts is essential to target interventions and allocate limited resources. METHODS: Using a hierarchical Bayesian framework we developed a spatial Poisson hurdle model to jointly model the probability of one or more paralytic polio cases, and the number of cases that would be detected in the event of an outbreak...
October 11, 2017: BMC Medicine
https://www.readbyqxmd.com/read/28988541/a-randomised-double-blind-clinical-phase-ii-trial-of-the-efficacy-safety-tolerability-and-pharmacokinetics-of-a-single-dose-combination-treatment-with-artefenomel-and-piperaquine-in-adults-and-children-with-uncomplicated-plasmodium-falciparum-malaria
#19
Fiona Macintyre, Yeka Adoke, Alfred B Tiono, Tran Thanh Duong, Ghyslain Mombo-Ngoma, Marielle Bouyou-Akotet, Halidou Tinto, Quique Bassat, Saadou Issifou, Marc Adamy, Helen Demarest, Stephan Duparc, Didier Leroy, Bart E Laurijssens, Sophie Biguenet, Afizi Kibuuka, Antoinette Kitoto Tshefu, Melnick Smith, Chanelle Foster, Illse Leipoldt, Peter G Kremsner, Bui Quang Phuc, Alphonse Ouedraogo, Michael Ramharter
BACKGROUND: The clinical development of a single encounter treatment for uncomplicated malaria has the potential to significantly improve the effectiveness of antimalarials. Exploratory data suggested that the combination of artefenomel and piperaquine phosphate (PQP) has the potential to achieve satisfactory cure rates as a single dose therapy. The primary objective of the study was to determine whether a single dose of artefenomel (800 mg) plus PQP in ascending doses is an efficacious treatment for uncomplicated Plasmodium falciparum malaria in the 'target' population of children ≤ 5 years of age in Africa as well as Asian patients of all ages...
October 9, 2017: BMC Medicine
https://www.readbyqxmd.com/read/28985726/correction-to-gestational-hypertensive-disorders-and-retinal-microvasculature-the-generation-r-study
#20
Laura Benschop, Sarah Schalekamp-Timmermans, Jeanine E Roeters van Lennep, Vincent W V Jaddoe, Tien Yin Wong, Carol Y Cheung, Eric A P Steegers, M Kamran Ikram
No abstract text is available yet for this article.
October 6, 2017: BMC Medicine
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