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BMC Medicine

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https://www.readbyqxmd.com/read/28427392/percutaneous-intervention-versus-coronary-artery-bypass-graft-surgery-in-left-main-coronary-artery-stenosis-a-systematic-review-and-meta-analysis
#1
Xin-Lin Zhang, Qing-Qing Zhu, Jing-Jing Yang, Yu-Han Chen, Yang Li, Su-Hui Zhu, Jun Xie, Lian Wang, Li-Na Kang, Biao Xu
BACKGROUND: The optimal revascularization technique in patients with left main coronary artery disease (CAD) remains controversial. We aimed to compare the long-term performance of percutaneous coronary intervention (PCI) versus coronary artery bypass graft (CABG) surgery in treatment of left main CAD. METHODS: PubMed, EMBASE, and the Cochrane Library were searched until November 16, 2016. RESULTS: Six randomized controlled trials and 22 matched observational studies including 22,487 patients and 90,167 patient-years of follow-up were included...
April 21, 2017: BMC Medicine
https://www.readbyqxmd.com/read/28427464/accuracy-of-low-density-lipoprotein-cholesterol-estimation-at-very-low-levels
#2
Renato Quispe, Aditya Hendrani, Mohamed B Elshazly, Erin D Michos, John W McEvoy, Michael J Blaha, Maciej Banach, Krishnaji R Kulkarni, Peter P Toth, Josef Coresh, Roger S Blumenthal, Steven R Jones, Seth S Martin
BACKGROUND: As the approach to low-density lipoprotein cholesterol (LDL-C) lowering becomes increasingly intensive, accurate assessment of LDL-C at very low levels warrants closer attention in individualized clinical efficacy and safety evaluation. We aimed to assess the accuracy of LDL-C estimation at very low levels by the Friedewald equation, the de facto clinical standard, and compare its accuracy with a novel, big data-derived LDL-C estimate. METHODS: In 191,333 individuals with Friedewald LDL-C < 70 mg/dL, we compared the accuracy of Friedewald and novel LDL-C values in relation to direct measurements by Vertical Auto Profile ultracentrifugation...
April 20, 2017: BMC Medicine
https://www.readbyqxmd.com/read/28427399/erratum-to-successes-and-failures-what-did-we-learn-from-recent-first-line-treatment-immunotherapy-trials-in-non-small-cell-lung-cancer
#3
Jordi Remon, Benjamin Besse, Jean-Charles Soria
No abstract text is available yet for this article.
April 20, 2017: BMC Medicine
https://www.readbyqxmd.com/read/28424070/antidepressant-use-and-cognitive-decline-in-community-dwelling-elderly-people-the-three-city-cohort
#4
Isabelle Carrière, Joanna Norton, Amandine Farré, Marilyn Wyart, Christophe Tzourio, Pernelle Noize, Karine Pérès, Annie Fourrier-Réglat, Karen Ritchie, Marie Laure Ancelin
BACKGROUND: Cognitive impairment is very common in late-life depression, principally affecting executive skills and information processing speed. The aim of the study was to examine the effect of antidepressant treatment on cognitive performances over a 10-year period. METHODS: The community-based cohort included 7381 participants aged 65 years and above. Five cognitive domains (verbal fluency, psychomotor speed, executive function, visuospatial skills and global cognition) were assessed up to five times over 10 years of follow-up...
April 19, 2017: BMC Medicine
https://www.readbyqxmd.com/read/28403846/the-new-field-of-precision-psychiatry
#5
Brisa S Fernandes, Leanne M Williams, Johann Steiner, Marion Leboyer, André F Carvalho, Michael Berk
BACKGROUND: Precision medicine is a new and important topic in psychiatry. Psychiatry has not yet benefited from the advanced diagnostic and therapeutic technologies that form an integral part of other clinical specialties. Thus, the vision of precision medicine as applied to psychiatry - 'precision psychiatry' - promises to be even more transformative than in other fields of medicine, which have already lessened the translational gap. DISCUSSION: Herein, we describe 'precision psychiatry' and how its several implications promise to transform the psychiatric landscape...
April 13, 2017: BMC Medicine
https://www.readbyqxmd.com/read/28399921/s100%C3%AE-as-a-serum-marker-in-endocrine-resistant-breast-cancer
#6
Sara Charmsaz, Éamon Hughes, Fiona T Bane, Paul Tibbitts, Marie McIlroy, Christopher Byrne, Sinéad Cocchiglia, Jean McBryan, Bryan T Hennessy, Róisín M Dwyer, Michael J Kerin, Arnold D Hill, Leonie S Young
BACKGROUND: Endocrine therapy is standard treatment for estrogen receptor (ER)-positive breast cancer. However, its efficacy is limited by intrinsic and acquired resistance. Here the potential of S100β as a biomarker and inhibition of its signaling network as a therapeutic strategy in endocrine treated patients was investigated. METHODS: The expression of S100β in tissue and serum was assessed by immunohistochemistry and an enzyme-linked immunosorbent assay, respectively...
April 12, 2017: BMC Medicine
https://www.readbyqxmd.com/read/28395660/incentivised-chronic-disease-management-and-the-inverse-equity-hypothesis-findings-from-a-longitudinal-analysis-of-scottish-primary-care-practice-level-data
#7
Richard Lowrie, Alex McConnachie, Andrea E Williamson, Evangelos Kontopantelis, Marie Forrest, Norman Lannigan, Stewart W Mercer, Frances S Mair
BACKGROUND: The inverse equity hypothesis asserts that new health policies initially widen inequality, then attenuate inequalities over time. Since 2004, the UK's pay-for-performance scheme for chronic disease management (CDM) in primary care general practices (the Quality and Outcomes Framework) has permitted practices to except (exclude) patients from attending annual CDM reviews, without financial penalty. Informed dissent (ID) is one component of exception rates, applied to patients who have not attended due to refusal or non-response to invitations...
April 11, 2017: BMC Medicine
https://www.readbyqxmd.com/read/28391775/patterns-of-care-and-outcomes-of-patients-with-metastatic-soft-tissue-sarcoma-in-a-real-life-setting-the-metasarc-observational-study
#8
Marion Savina, Axel Le Cesne, Jean-Yves Blay, Isabelle Ray-Coquard, Olivier Mir, Maud Toulmonde, Sophie Cousin, Philippe Terrier, Dominique Ranchere-Vince, Pierre Meeus, Eberhard Stoeckle, Charles Honoré, Paul Sargos, Marie-Pierre Sunyach, Cécile Le Péchoux, Antoine Giraud, Carine Bellera, François Le Loarer, Antoine Italiano
BACKGROUND: Well-designed observational studies of individuals with rare tumors are needed to improve patient care, clinical investigations, and the education of healthcare professionals. METHODS: The patterns of care, outcomes, and prognostic factors of a cohort of 2225 patients with metastatic soft tissue sarcomas who were diagnosed between 1990 and 2013 and documented in the prospectively maintained database of the French Sarcoma Group were analyzed. RESULTS: The median number of systemic treatments was 3 (range, 1-6); 27% of the patients did not receive any systemic treatment and 1054 (49%) patients underwent locoregional treatment of the metastasis...
April 10, 2017: BMC Medicine
https://www.readbyqxmd.com/read/28385152/addressing-a-clinical-challenge-guidelines-for-the-diagnosis-and-treatment-of-leishmaniasis
#9
Naomi E Aronson
Leishmaniasis is a chronic intracellular parasitic infection that travelers, immigrants, deployed military personnel, and refugees from endemic global areas acquire from the bite of infected sand flies and carry with them, including to non-endemic countries where leishmaniasis may be an unfamiliar illness to medical providers. This commentary discusses the first clinical practice guidelines produced by the Infectious Diseases Society of America and American Society of Tropical Medicine and Hygiene for the diagnosis and management of leishmaniasis, targeted for clinicians in North America...
April 7, 2017: BMC Medicine
https://www.readbyqxmd.com/read/28381299/emerging-concepts-in-liquid-biopsies
#10
REVIEW
Samantha Perakis, Michael R Speicher
Characterizing and monitoring tumor genomes with blood samples could achieve significant improvements in precision medicine. As tumors shed parts of themselves into the circulation, analyses of circulating tumor cells, circulating tumor DNA, and tumor-derived exosomes, often referred to as "liquid biopsies", may enable tumor genome characterization by minimally invasive means. Indeed, multiple studies have described how molecular information about parent tumors can be extracted from these components. Here, we briefly summarize current technologies and then elaborate on emerging novel concepts that may further propel the field...
April 6, 2017: BMC Medicine
https://www.readbyqxmd.com/read/28376771/ehealth-in-the-future-of-medications-management-personalisation-monitoring-and-adherence
#11
EDITORIAL
Josip Car, Woan Shin Tan, Zhilian Huang, Peter Sloot, Bryony Dean Franklin
BACKGROUND: Globally, healthcare systems face major challenges with medicines management and medication adherence. Medication adherence determines medication effectiveness and can be the single most effective intervention for improving health outcomes. In anticipation of growth in eHealth interventions worldwide, we explore the role of eHealth in the patients' medicines management journey in primary care, focusing on personalisation and intelligent monitoring for greater adherence. DISCUSSION: eHealth offers opportunities to transform every step of the patient's medicines management journey...
April 5, 2017: BMC Medicine
https://www.readbyqxmd.com/read/28372583/exposure-to-bacterial-products-lipopolysaccharide-and-flagellin-and-hepatocellular-carcinoma-a-nested-case-control-study
#12
Veronika Fedirko, Hao Quang Tran, Andrew T Gewirtz, Magdalena Stepien, Antonia Trichopoulou, Krasimira Aleksandrova, Anja Olsen, Anne Tjønneland, Kim Overvad, Franck Carbonnel, Marie-Christine Boutron-Ruault, Gianluca Severi, Tilman Kühn, Rudolf Kaaks, Heiner Boeing, Christina Bamia, Pagona Lagiou, Sara Grioni, Salvatore Panico, Domenico Palli, Rosario Tumino, Alessio Naccarati, Petra H Peeters, H B Bueno-de-Mesquita, Elisabete Weiderpass, José María Huerta Castaño, Aurelio Barricarte, María-José Sánchez, Miren Dorronsoro, J Ramón Quirós, Antonio Agudo, Klas Sjöberg, Bodil Ohlsson, Oskar Hemmingsson, Mårten Werner, Kathryn E Bradbury, Kay-Tee Khaw, Nick Wareham, Konstantinos K Tsilidis, Dagfinn Aune, Augustin Scalbert, Isabelle Romieu, Elio Riboli, Mazda Jenab
BACKGROUND: Leakage of bacterial products across the gut barrier may play a role in liver diseases which often precede the development of liver cancer. However, human studies, particularly from prospective settings, are lacking. METHODS: We used a case-control study design nested within a large prospective cohort to assess the association between circulating levels of anti-lipopolysaccharide (LPS) and anti-flagellin immunoglobulin A (IgA) and G (IgG) (reflecting long-term exposures to LPS and flagellin, respectively) and risk of hepatocellular carcinoma...
April 4, 2017: BMC Medicine
https://www.readbyqxmd.com/read/28366170/treatment-duration-of-febrile-urinary-tract-infection-a-pragmatic-randomized-double-blind-placebo-controlled-non-inferiority-trial-in-men-and-women
#13
Cees van Nieuwkoop, Willize E van der Starre, Janneke E Stalenhoef, Anna M van Aartrijk, Tanny J K van der Reijden, Albert M Vollaard, Nathalie M Delfos, Jan W van 't Wout, Jeanet W Blom, Ida C Spelt, Eliane M S Leyten, Ted Koster, Hans C Ablij, Martha T van der Beek, Mirjam J Knol, Jaap T van Dissel
BACKGROUND: In adults with febrile urinary tract infection (fUTI), data on optimal treatment duration in patients other than non-pregnant women without comorbidities are lacking. METHODS: A randomized placebo-controlled, double-blind, non-inferiority trial among 35 primary care centers and 7 emergency departments of regional hospitals in the Netherlands. Women and men aged ≥ 18 years with a diagnosis of fUTI were randomly assigned to receive antibiotic treatment for 7 or 14 days (the second week being ciprofloxacin 500 mg or placebo orally twice daily)...
April 3, 2017: BMC Medicine
https://www.readbyqxmd.com/read/28359271/the-2016-classification-criteria-for-primary-sjogren-s-syndrome-what-s-new
#14
Franco Franceschini, Ilaria Cavazzana, Laura Andreoli, Angela Tincani
New 2016 ACR/EULAR classification criteria for primary Sjogren's syndrome (SS) have been developed and endorsed by the ACR. The newly proposed criteria include simple-to-perform items.Two important points of the new criteria should be considered. Firstly, they indicate that either salivary gland biopsy or anti-Ro must be positive in order to corroborate the inflammatory and autoimmune nature of the disease. Secondly, the criteria recognize the systemic nature of SS, namely that patients without salivary or ocular glandular symptoms, but with extraglandular manifestations and B cell activation markers were also included in the SS classification...
March 31, 2017: BMC Medicine
https://www.readbyqxmd.com/read/28356148/prediction-of-complications-in-early-onset-pre-eclampsia-prep-development-and-external-multinational-validation-of-prognostic-models
#15
Shakila Thangaratinam, John Allotey, Nadine Marlin, Julie Dodds, Fiona Cheong-See, Peter von Dadelszen, Wessel Ganzevoort, Joost Akkermans, Sally Kerry, Ben W Mol, Karl G M Moons, Richard D Riley, Khalid S Khan
BACKGROUND: Unexpected clinical deterioration before 34 weeks gestation is an undesired course in early-onset pre-eclampsia. To safely prolong preterm gestation, accurate and timely prediction of complications is required. METHOD: Women with confirmed early onset pre-eclampsia were recruited from 53 maternity units in the UK to a large prospective cohort study (PREP-946) for development of prognostic models for the overall risk of experiencing a complication using logistic regression (PREP-L), and for predicting the time to adverse maternal outcome using a survival model (PREP-S)...
March 30, 2017: BMC Medicine
https://www.readbyqxmd.com/read/28356103/erratum-to-unraveling-the-associations-of-age-and-menopause-with-cardiovascular-risk-factors-in-a-large-population-based-study
#16
A C de Kat, V Dam, N C Onland-Moret, M J C Eijkemans, F J M Broekmans, Y T van der Schouw
No abstract text is available yet for this article.
March 29, 2017: BMC Medicine
https://www.readbyqxmd.com/read/28351427/use-of-whole-genome-sequencing-to-distinguish-relapse-from-reinfection-in-a-completed-tuberculosis-clinical-trial
#17
Adam A Witney, Anna L E Bateson, Amina Jindani, Patrick P J Phillips, David Coleman, Neil G Stoker, Philip D Butcher, Timothy D McHugh
BACKGROUND: RIFAQUIN was a tuberculosis chemotherapy trial in southern Africa including regimens with high-dose rifapentine with moxifloxacin. Here, the application of whole-genome sequencing (WGS) is evaluated within RIFAQUIN for identifying new infections in treated patients as either relapses or reinfections. WGS is further compared with mycobacterial interspersed repetitive units-variable number tandem repeats (MIRU-VNTR) typing. This is the first report of WGS being used to evaluate new infections in a completed clinical trial for which all treatment and epidemiological data are available for analysis...
March 29, 2017: BMC Medicine
https://www.readbyqxmd.com/read/28347337/the-effect-of-intervening-hospitalizations-on-the-benefit-of-structured-physical-activity-in-promoting-independent-mobility-among-community-living-older-persons-secondary-analysis-of-a-randomized-controlled-trial
#18
Thomas M Gill, Daniel P Beavers, Jack M Guralnik, Marco Pahor, Roger A Fielding, Michelle Hauser, Todd M Manini, Anthony P Marsh, Mary M McDermott, Anne B Newman, Heather G Allore, Michael E Miller
BACKGROUND: Among older persons, disability is often precipitated by intervening illnesses and injuries leading to hospitalization. In the Lifestyle Interventions and Independence for Elders (LIFE) Study, a structured moderate-intensity physical activity program, compared with a health education program, was shown to significantly reduce the amount of time spent with major mobility disability (MMD) over the course of 3.5 years. We aimed to determine whether the benefit of the physical activity program in promoting independent mobility was diminished in the setting of intervening hospitalizations...
March 28, 2017: BMC Medicine
https://www.readbyqxmd.com/read/28343451/the-association-between-the-day-of-the-week-of-milestones-in-the-care-pathway-of-patients-with-hip-fracture-and-30-day-mortality-findings-from-a-prospective-national-registry-the-national-hip-fracture-database-of-england-and-wales
#19
Adrian Sayers, Michael R Whitehouse, James R Berstock, Karen A Harding, Michael B Kelly, Timothy J Chesser
BACKGROUND: Recent publications indicate increased mortality in patients admitted to hospital at the weekend, but these findings may be subject to inadequate adjustment for case-mix and the complexities of resource provision. Hip fractures generally occur in a frail comorbid population with a consistent diagnosis precipitating admission as an emergency. We therefore aimed to examine the association between the day of the week of milestones in the care pathway and 30-day mortality in this population...
March 27, 2017: BMC Medicine
https://www.readbyqxmd.com/read/28335792/can-incontinence-be-cured-a-systematic-review-of-cure-rates
#20
Rob Riemsma, Suzanne Hagen, Ruth Kirschner-Hermanns, Christine Norton, Helle Wijk, Karl-Erik Andersson, Christopher Chapple, Julian Spinks, Adrian Wagg, Edward Hutt, Kate Misso, Sohan Deshpande, Jos Kleijnen, Ian Milsom
BACKGROUND: Incontinence constitutes a major health problem affecting millions of people worldwide. The present study aims to assess cure rates from treating urinary (UI) or fecal incontinence (FI) and the number of people who may remain dependent on containment strategies. METHODS: Medline, Embase, PsycINFO, Cochrane Central Register of Controlled Trials (CENTRAL), CINAHL, and PEDro were searched from January 2005 to June 2015. Supplementary searches included conference abstracts and trials registers (2013-2015)...
March 24, 2017: BMC Medicine
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