journal
MENU ▼
Read by QxMD icon Read
search

BMC Medicine

journal
https://www.readbyqxmd.com/read/28934987/lifestyle-precision-medicine-the-next-generation-in-type-2-diabetes-prevention
#1
REVIEW
Pascal M Mutie, Giuseppe N Giordano, Paul W Franks
The driving force behind the current global type 2 diabetes epidemic is insulin resistance in overweight and obese individuals. Dietary factors, physical inactivity, and sedentary behaviors are the major modifiable risk factors for obesity. Nevertheless, many overweight/obese people do not develop diabetes and lifestyle interventions focused on weight loss and diabetes prevention are often ineffective. Traditionally, chronically elevated blood glucose concentrations have been the hallmark of diabetes; however, many individuals will either remain 'prediabetic' or regress to normoglycemia...
September 22, 2017: BMC Medicine
https://www.readbyqxmd.com/read/28927421/a-25-gene-classifier-predicts-overall-survival-in-resectable-pancreatic-cancer
#2
David J Birnbaum, Pascal Finetti, Alexia Lopresti, Marine Gilabert, Flora Poizat, Jean-Luc Raoul, Jean-Robert Delpero, Vincent Moutardier, Daniel Birnbaum, Emilie Mamessier, François Bertucci
BACKGROUND: Pancreatic carcinoma is one of the most lethal human cancers. In patients with resectable tumors, surgery followed by adjuvant chemotherapy is the only curative treatment. However, the 5-year survival is 20%. Because of a strong metastatic propensity, neoadjuvant chemotherapy is being tested in randomized clinical trials. In this context, improving the selection of patients for immediate surgery or neoadjuvant chemotherapy is crucial, and high-throughput molecular analyses may help; the present study aims to address this...
September 20, 2017: BMC Medicine
https://www.readbyqxmd.com/read/28918754/macrophage-activation-like-syndrome-an-immunological-entity-associated-with-rapid-progression-to-death-in-sepsis
#3
Evdoxia Kyriazopoulou, Konstantinos Leventogiannis, Anna Norrby-Teglund, Georgios Dimopoulos, Aikaterini Pantazi, Stylianos E Orfanos, Nikoletta Rovina, Iraklis Tsangaris, Theologia Gkavogianni, Elektra Botsa, Eleftheria Chassiou, Anastasia Kotanidou, Christina Kontouli, Panagiotis Chaloulis, Dimitrios Velissaris, Athina Savva, Jonas-Sundén Cullberg, Karolina Akinosoglou, Charalambos Gogos, Apostolos Armaganidis, Evangelos J Giamarellos-Bourboulis
BACKGROUND: A subanalysis of a randomized clinical trial indicated sepsis survival benefit from interleukin (IL)-1 blockade in patients with features of the macrophage activation-like syndrome (MALS). This study aimed to investigate the frequency of MALS and to develop a biomarker of diagnosis and prognosis. METHODS: Patients with infections and systemic inflammatory response syndrome were assigned to one test cohort (n = 3417) and a validation cohort (n = 1704)...
September 18, 2017: BMC Medicine
https://www.readbyqxmd.com/read/28911326/borrelia-infection-and-risk-of-celiac-disease
#4
Armin Alaedini, Benjamin Lebwohl, Gary P Wormser, Peter H Green, Jonas F Ludvigsson
BACKGROUND: Environmental factors, including infectious agents, are speculated to play a role in the rising prevalence and the geographic distribution of celiac disease, an autoimmune disorder. In the USA and Sweden where the regional variation in the frequency of celiac disease has been studied, a similarity with the geographic distribution of Lyme disease, an emerging multisystemic infection caused by Borrelia burgdorferi spirochetes, has been found, thus raising the possibility of a link...
September 15, 2017: BMC Medicine
https://www.readbyqxmd.com/read/28903777/modest-heterologous-protection-after-plasmodium-falciparum-sporozoite-immunization-a-double-blind-randomized-controlled-clinical-trial
#5
Jona Walk, Isaie J Reuling, Marije C Behet, Lisette Meerstein-Kessel, Wouter Graumans, Geert-Jan van Gemert, Rianne Siebelink-Stoter, Marga van de Vegte-Bolmer, Thorsten Janssen, Karina Teelen, Johannes H W de Wilt, Quirijn de Mast, André J van der Ven, Ernest Diez Benavente, Susana Campino, Taane G Clark, Martijn A Huynen, Cornelus C Hermsen, Else M Bijker, Anja Scholzen, Robert W Sauerwein
BACKGROUND: A highly efficacious vaccine is needed for malaria control and eradication. Immunization with Plasmodium falciparum NF54 parasites under chemoprophylaxis (chemoprophylaxis and sporozoite (CPS)-immunization) induces the most efficient long-lasting protection against a homologous parasite. However, parasite genetic diversity is a major hurdle for protection against heterologous strains. METHODS: We conducted a double-blind, randomized controlled trial in 39 healthy participants of NF54-CPS immunization by bites of 45 NF54-infected (n = 24 volunteers) or uninfected mosquitoes (placebo; n = 15 volunteers) against a controlled human malaria infection with the homologous NF54 or the genetically distinct NF135...
September 13, 2017: BMC Medicine
https://www.readbyqxmd.com/read/28893269/core-competencies-for-scientific-editors-of-biomedical-journals-consensus-statement
#6
David Moher, James Galipeau, Sabina Alam, Virginia Barbour, Kidist Bartolomeos, Patricia Baskin, Sally Bell-Syer, Kelly D Cobey, Leighton Chan, Jocalyn Clark, Jonathan Deeks, Annette Flanagin, Paul Garner, Anne-Marie Glenny, Trish Groves, Kurinchi Gurusamy, Farrokh Habibzadeh, Stefanie Jewell-Thomas, Diane Kelsall, José Florencio Lapeña, Harriet MacLehose, Ana Marusic, Joanne E McKenzie, Jay Shah, Larissa Shamseer, Sharon Straus, Peter Tugwell, Elizabeth Wager, Margaret Winker, Getu Zhaori
BACKGROUND: Scientific editors are responsible for deciding which articles to publish in their journals. However, we have not found documentation of their required knowledge, skills, and characteristics, or the existence of any formal core competencies for this role. METHODS: We describe the development of a minimum set of core competencies for scientific editors of biomedical journals. RESULTS: The 14 key core competencies are divided into three major areas, and each competency has a list of associated elements or descriptions of more specific knowledge, skills, and characteristics that contribute to its fulfillment...
September 11, 2017: BMC Medicine
https://www.readbyqxmd.com/read/28882149/cost-effectiveness-analysis-of-quadrivalent-seasonal-influenza-vaccines-in-england
#7
Dominic Thorrington, Edwin van Leeuwen, Mary Ramsay, Richard Pebody, Marc Baguelin
BACKGROUND: As part of the national seasonal influenza vaccination programme in England and Wales, children receive a quadrivalent vaccine offering protection against two influenza A strains and two influenza B strains. Healthy children receive a quadrivalent live attenuated influenza vaccine (QLAIV), whilst children with contraindications receive the quadrivalent inactivated influenza vaccine (QIIV). Individuals aged younger than 65 years in the clinical risk populations and elderly individuals aged 65+ years receive either a trivalent inactivated influenza vaccine (TIIV) offering protection from two A strains and one B strain or the QIIV at the choice of their general practitioner...
September 8, 2017: BMC Medicine
https://www.readbyqxmd.com/read/28859688/a-13-gene-expression-based-radioresistance-score-highlights-the-heterogeneity-in-the-response-to-radiation-therapy-across-hpv-negative-hnscc-molecular-subtypes
#8
Jean-Philippe Foy, Louis Bazire, Sandra Ortiz-Cuaran, Sophie Deneuve, Janice Kielbassa, Emilie Thomas, Alain Viari, Alain Puisieux, Patrick Goudot, Chloé Bertolus, Nicolas Foray, Youlia Kirova, Pierre Verrelle, Pierre Saintigny
BACKGROUND: Radiotherapy for head and neck squamous cell carcinomas (HNSCC) is associated with a substantial morbidity and inconsistent efficacy. Human papillomavirus (HPV)-positive status is recognized as a marker of increased radiosensitivity. Our goal was to identify molecular markers associated with benefit to radiotherapy in patients with HPV-negative disease. METHODS: Gene expression profiles from public repositories were downloaded for data mining. Training sets included 421 HPV-negative HNSCC tumors from The Cancer Genome Atlas (TCGA) and 32 HNSCC cell lines with available radiosensitivity data (GSE79368)...
September 1, 2017: BMC Medicine
https://www.readbyqxmd.com/read/28854913/reduced-growth-velocity-across-the-third-trimester-is-associated-with-placental-insufficiency-in-fetuses-born-at-a-normal-birthweight-a-prospective-cohort-study
#9
Teresa M MacDonald, Lisa Hui, Stephen Tong, Alice J Robinson, Kirsten M Dane, Anna L Middleton, Susan P Walker
BACKGROUND: While being small-for-gestational-age due to placental insufficiency is a major risk factor for stillbirth, 50% of stillbirths occur in appropriate-for-gestational-age (AGA, > 10th centile) fetuses. AGA fetuses are plausibly also at risk of stillbirth if placental insufficiency is present. Such fetuses may be expected to demonstrate declining growth trajectory across pregnancy, although they do not fall below the 10th centile before birth. We investigated whether reduced growth velocity in AGA fetuses is associated with antenatal, intrapartum and neonatal indicators of placental insufficiency...
August 31, 2017: BMC Medicine
https://www.readbyqxmd.com/read/28851373/a-pragmatic-lifestyle-modification-programme-reduces-the-incidence-of-predictors-of-cardio-metabolic-disease-and-dysglycaemia-in-a-young-healthy-urban-south-asian-population-a-randomised-controlled-trial
#10
Mahen Wijesuriya, Nikolaos Fountoulakis, Nicola Guess, Sarath Banneheka, Laksha Vasantharajah, Martin Gulliford, Giancarlo Viberti, Luigi Gnudi, Janaka Karalliedde
BACKGROUND: There is an increasing incidence of type 2 diabetes mellitus (T2DM) in young urban South-Asians. We tested the effect of a pragmatic trimonthly lifestyle modification (LSM) programme (P-LSM) versus a less-intensive 12-monthly control LSM (C-LSM) intervention on a primary composite endpoint of predictors of cardio-metabolic disease (new onset T2DM, hypertension, impaired glucose tolerance (IGT), impaired fasting glycaemia (IFG) and markers of cardio-renal disease) in participants aged 5-40 years with risk factors for T2DM...
August 30, 2017: BMC Medicine
https://www.readbyqxmd.com/read/28844206/gestational-diabetes-mellitus-right-person-right-treatment-right-time
#11
Robert S Lindsay, Sharon T Mackin, Scott M Nelson
BACKGROUND: Personalised treatment that is uniquely tailored to an individual's phenotype has become a key goal of clinical and pharmaceutical development across many, particularly chronic, diseases. For type 2 diabetes, the importance of the underlying clinical heterogeneity of the condition is emphasised and a range of treatments are now available, with personalised approaches being developed. While a close connection between risk factors for type 2 diabetes and gestational diabetes has long been acknowledged, stratification of screening, treatment and obstetric intervention remains in its infancy...
August 28, 2017: BMC Medicine
https://www.readbyqxmd.com/read/28838313/trade-off-between-benefits-harms-and-economic-efficiency-of-low-dose-ct-lung-cancer-screening-a-microsimulation-analysis-of-nodule-management-strategies-in-a-population-based-setting
#12
Marina Treskova, Ines Aumann, Heiko Golpon, Jens Vogel-Claussen, Tobias Welte, Alexander Kuhlmann
BACKGROUND: In lung cancer screening, a nodule management protocol describes nodule assessment and thresholds for nodule size and growth rate to identify patients who require immediate diagnostic evaluation or additional imaging exams. The Netherlands-Leuvens Screening Trial and the National Lung Screening Trial used different selection criteria and nodule management protocols. Several modelling studies have reported variations in screening outcomes and cost-effectiveness across selection criteria and screening intervals; however, the effect of variations in the nodule management protocol remains uncertain...
August 25, 2017: BMC Medicine
https://www.readbyqxmd.com/read/28835246/the-contribution-of-risk-factors-to-socioeconomic-inequalities-in-multimorbidity-across-the-lifecourse-a-longitudinal-analysis-of-the-twenty-07-cohort
#13
Srinivasa Vittal Katikireddi, Kathryn Skivington, Alastair H Leyland, Kate Hunt, Stewart W Mercer
BACKGROUND: Multimorbidity is a major challenge to health systems globally and disproportionately affects socioeconomically disadvantaged populations. We examined socioeconomic inequalities in developing multimorbidity across the lifecourse and investigated the contribution of five behaviour-related risk factors. METHODS: The Twenty-07 study recruited participants aged approximately 15, 35, and 55 years in 1987 and followed them up over 20 years. The primary outcome was development of multimorbidity (2+ health conditions)...
August 24, 2017: BMC Medicine
https://www.readbyqxmd.com/read/28830535/association-of-bariatric-surgery-with-risk-of-acute-care-use-for-hypertension-related-disease-in-obese-adults-population-based-self-controlled-case-series-study
#14
Yuichi J Shimada, Yusuke Tsugawa, Hiroyasu Iso, David F M Brown, Kohei Hasegawa
BACKGROUND: Hypertension carries a large societal burden. Obesity is known as a risk factor for hypertension. However, little is known as to whether weight loss interventions reduce the risk of hypertension-related adverse events, such as acute care use (emergency department [ED] visit and/or unplanned hospitalization). We used bariatric surgery as an instrument for investigating the effect of large weight reduction on the risk of acute care use for hypertension-related disease in obese adults with hypertension...
August 23, 2017: BMC Medicine
https://www.readbyqxmd.com/read/28826404/highlights-in-soft-tissue-sarcomas-and-gastrointestinal-stromal-tumours-gist-trials-reported-at-asco-2017-annual-meeting
#15
LETTER
Anna Maria Frezza, Silvia Stacchiotti, Alessandro Gronchi
Herein, we summarise the results of the most relevant studies presented at the 2017 ASCO Annual Meeting in the field of soft tissue sarcomas (STSs) and gastrointestinal stromal tumours (GISTs). Innovations on the management of localised disease, highlights from the different experiences in the metastatic setting and large studies on rare histologies will be included. Special attention will be paid to results on immunotherapy, antiangiogenics use in histology with limited sensitivity to standard chemotherapy and new compounds...
August 22, 2017: BMC Medicine
https://www.readbyqxmd.com/read/28823248/the-impact-of-repeated-vaccination-on-influenza-vaccine-effectiveness-a-systematic-review-and-meta-analysis
#16
Lauren C Ramsay, Sarah A Buchan, Robert G Stirling, Benjamin J Cowling, Shuo Feng, Jeffrey C Kwong, Bryna F Warshawsky
BACKGROUND: Conflicting results regarding the impact of repeated vaccination on influenza vaccine effectiveness (VE) may cause confusion regarding the benefits of receiving the current season's vaccine. METHODS: We systematically searched MEDLINE, Embase, PubMed, and Cumulative Index to Nursing and Allied Health Literature from database inception to August 17, 2016, for observational studies published in English that reported VE against laboratory-confirmed influenza for four vaccination groups, namely current season only, prior season only, both seasons, and neither season...
August 21, 2017: BMC Medicine
https://www.readbyqxmd.com/read/28818081/what-makes-gouty-inflammation-so-variable
#17
REVIEW
Robert Terkeltaub
Acute gout arthritis flares contribute dominantly to gout-specific impaired health-related quality of life, representing a progressively increasing public health problem. Flares can be complex and expensive to treat, partly due to the frequent comorbidities. Unmet needs in gout management are more pressing given the markedly increasing gout flare hospital admission rates. In addition, chronic gouty arthritis can cause joint damage and functional impairment. This review addresses new knowledge on the basis for the marked, inherent variability of responses to deposited urate crystals, including the unpredictable and self-limited aspects of many gout flares...
August 18, 2017: BMC Medicine
https://www.readbyqxmd.com/read/28814291/circulating-tumor-dna-for-personalized-lung-cancer-monitoring
#18
LETTER
Clare Fiala, Eleftherios P Diamandis
Advances in deep sequencing technology have led to developments in personalized medicine. Here, we describe the implications of a recent investigation that sequenced ctDNA from the plasma of non-small cell lung cancer patients to develop personalized ctDNA tests. These 'liquid biopsies' have shown promise in monitoring tumor growth and response to treatment, providing a timely overview of mutations present in the tumor. We discuss the advantages of this budding approach, as well as its challenges and drawbacks, while also providing areas for further investigation and an outlook for the future...
August 17, 2017: BMC Medicine
https://www.readbyqxmd.com/read/28810856/ibrutinib-continues-to-influence-the-therapeutic-landscape-of-chronic-lymphocytic-leukemia-new-data-presented-at-asco-2017
#19
LETTER
Stefano Molica
According to data presented at the 2017 American Society of Oncology (ASCO) Annual Meeting, with more than 4 years of follow-up, ibrutinib continues to provide clinical utility in chronic lymphocytic leukemia (CLL). However, treatment of CLL patients with high-risk cytogenetics features remains a challenge and the outcome of these hard-to-treat patients is dismal. At the 2017 ASCO Meeting, results of the GENUINE phase III trial showed that, by adding ublituximab, a glycoengineered, anti-CD20 type 1 monoclonal antibody, to ibrutinib, the overall response rate (ORR), complete response rate (CRR), and minimal residual disease (MRD) negativity may be improved in high-risk CLL patients...
August 16, 2017: BMC Medicine
https://www.readbyqxmd.com/read/28806964/intervention-now-to-eliminate-repeat-unintended-pregnancy-in-teenagers-interupt-a-systematic-review-of-intervention-effectiveness-and-cost-effectiveness-and-qualitative-and-realist-synthesis-of-implementation-factors-and-user-engagement
#20
Rabeea'h W Aslam, Maggie Hendry, Andrew Booth, Ben Carter, Joanna M Charles, Noel Craine, Rhiannon Tudor Edwards, Jane Noyes, Lupetu Ives Ntambwe, Diana Pasterfield, Jo Rycroft-Malone, Nefyn Williams, Rhiannon Whitaker
BACKGROUND: Unintended repeat conceptions can result in emotional, psychological and educational harm to young women, often with enduring implications for their life chances. This study aimed to identify which young women are at the greatest risk of repeat unintended pregnancies; which interventions are effective and cost-effective; and what are the barriers to and facilitators for the uptake of these interventions. METHODS: We conducted a mixed-methods systematic review which included meta-analysis, framework synthesis and application of realist principles, with stakeholder input and service user feedback to address this...
August 15, 2017: BMC Medicine
journal
journal
40551
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"