journal
MENU ▼
Read by QxMD icon Read
search

BMC Biology

journal
https://www.readbyqxmd.com/read/29776407/comparative-genomics-of-the-miniature-wasp-and-pest-control-agent-trichogramma-pretiosum
#1
Amelia R I Lindsey, Yogeshwar D Kelkar, Xin Wu, Dan Sun, Ellen O Martinson, Zhichao Yan, Paul F Rugman-Jones, Daniel S T Hughes, Shwetha C Murali, Jiaxin Qu, Shannon Dugan, Sandra L Lee, Hsu Chao, Huyen Dinh, Yi Han, Harsha Vardhan Doddapaneni, Kim C Worley, Donna M Muzny, Gongyin Ye, Richard A Gibbs, Stephen Richards, Soojin V Yi, Richard Stouthamer, John H Werren
BACKGROUND: Trichogrammatids are minute parasitoid wasps that develop within other insect eggs. They are less than half a millimeter long, smaller than some protozoans. The Trichogrammatidae are one of the earliest branching families of Chalcidoidea: a diverse superfamily of approximately half a million species of parasitoid wasps, proposed to have evolved from a miniaturized ancestor. Trichogramma are frequently used in agriculture, released as biological control agents against major moth and butterfly pests...
May 18, 2018: BMC Biology
https://www.readbyqxmd.com/read/29764437/caring-for-parents-an-evolutionary-rationale
#2
J Garay, S Számadó, Z Varga, E Szathmáry
BACKGROUND: The evolutionary roots of human moral behavior are a key precondition to understanding human nature. Investigations usually start with a social dilemma and end up with a norm that can provide some insight into the origin of morality. We take the opposite direction by investigating whether the cultural norm that promotes helping parents and which is respected in different variants across cultures and is codified in several religions can spread through Darwinian competition...
May 15, 2018: BMC Biology
https://www.readbyqxmd.com/read/29759067/small-rna-profiling-of-low-biomass-samples-identification-and-removal-of-contaminants
#3
Anna Heintz-Buschart, Dilmurat Yusuf, Anne Kaysen, Alton Etheridge, Joëlle V Fritz, Patrick May, Carine de Beaufort, Bimal B Upadhyaya, Anubrata Ghosal, David J Galas, Paul Wilmes
BACKGROUND: Sequencing-based analyses of low-biomass samples are known to be prone to misinterpretation due to the potential presence of contaminating molecules derived from laboratory reagents and environments. DNA contamination has been previously reported, yet contamination with RNA is usually considered to be very unlikely due to its inherent instability. Small RNAs (sRNAs) identified in tissues and bodily fluids, such as blood plasma, have implications for physiology and pathology, and therefore the potential to act as disease biomarkers...
May 14, 2018: BMC Biology
https://www.readbyqxmd.com/read/29730990/time-resolved-transcriptome-and-proteome-landscape-of-human-regulatory-t-cell-treg-differentiation-reveals-novel-regulators-of-foxp3
#4
Angelika Schmidt, Francesco Marabita, Narsis A Kiani, Catharina C Gross, Henrik J Johansson, Szabolcs Éliás, Sini Rautio, Matilda Eriksson, Sunjay Jude Fernandes, Gilad Silberberg, Ubaid Ullah, Urvashi Bhatia, Harri Lähdesmäki, Janne Lehtiö, David Gomez-Cabrero, Heinz Wiendl, Riitta Lahesmaa, Jesper Tegnér
BACKGROUND: Regulatory T cells (Tregs) expressing the transcription factor FOXP3 are crucial mediators of self-tolerance, preventing autoimmune diseases but possibly hampering tumor rejection. Clinical manipulation of Tregs is of great interest, and first-in-man trials of Treg transfer have achieved promising outcomes. Yet, the mechanisms governing induced Treg (iTreg) differentiation and the regulation of FOXP3 are incompletely understood. RESULTS: To gain a comprehensive and unbiased molecular understanding of FOXP3 induction, we performed time-series RNA sequencing (RNA-Seq) and proteomics profiling on the same samples during human iTreg differentiation...
May 7, 2018: BMC Biology
https://www.readbyqxmd.com/read/29720174/early-life-diet-conditions-the-molecular-response-to-post-weaning-protein-restriction-in-the-mouse
#5
Amy F Danson, Sarah J Marzi, Robert Lowe, Michelle L Holland, Vardhman K Rakyan
BACKGROUND: Environmental influences fluctuate throughout the life course of an organism. It is therefore important to understand how the timing of exposure impacts molecular responses. Herein, we examine the responses of two key molecular markers of dietary stress, namely variant-specific methylation at ribosomal DNA (rDNA) and small RNA distribution, including tRNA fragments, in a mouse model of protein restriction (PR) with exposure at pre- and/or post-weaning. RESULTS: We first confirm that pre-weaning PR exposure modulates the methylation state of rDNA in a genotype-dependent manner, whereas post-weaning PR exposure has no such effect...
May 2, 2018: BMC Biology
https://www.readbyqxmd.com/read/29712573/green-monomeric-photosensitizing-fluorescent-protein-for-photo-inducible-protein-inactivation-and-cell-ablation
#6
Yemima Dani Riani, Tomoki Matsuda, Kiwamu Takemoto, Takeharu Nagai
BACKGROUND: Photosensitizing fluorescent proteins, which generate reactive oxygen species (ROS) upon light irradiation, are useful for spatiotemporal protein inactivation and cell ablation. They give us clues about protein function, intracellular signaling pathways and intercellular interactions. Since ROS generation of a photosensitizer is specifically controlled by certain excitation wavelengths, utilizing colour variants of photosensitizing protein would allow multi-spatiotemporal control of inactivation...
April 30, 2018: BMC Biology
https://www.readbyqxmd.com/read/29706137/position-specific-intron-retention-is-mediated-by-the-histone-methyltransferase-sdg725
#7
Gang Wei, Kunpeng Liu, Ting Shen, Jinlei Shi, Bing Liu, Miao Han, Maolin Peng, Haihui Fu, Yifan Song, Jun Zhu, Aiwu Dong, Ting Ni
BACKGROUND: Intron retention (IR), the most prevalent alternative splicing form in plants, plays a critical role in gene expression during plant development and stress response. However, the molecular mechanisms underlying IR regulation remain largely unknown. RESULTS: Knockdown of SDG725, a histone H3 lysine 36 (H3K36)-specific methyltransferase in rice, leads to alterations of IR in more than 4700 genes. Surprisingly, IR events are globally increased at the 5' region but decreased at the 3' region of the gene body in the SDG725-knockdown mutant...
April 30, 2018: BMC Biology
https://www.readbyqxmd.com/read/29703257/insp-3-r-sec5-interaction-on-phagosomes-modulates-innate-immunity-to-candida-albicans-by-promoting-cytosolic-ca-2-elevation-and-tbk1-activity
#8
Long Yang, Wenwen Gu, King-Ho Cheung, Lan Yan, Benjamin Chun-Kit Tong, Yuanying Jiang, Jun Yang
BACKGROUND: Candida albicans (C. albicans) invasion triggers antifungal innate immunity, and the elevation of cytoplasmic Ca2+ levels via the inositol 1,4,5-trisphosphate receptor (InsP3 R) plays a critical role in this process. However, the molecular pathways linking the InsP3 R-mediated increase in Ca2+ and immune responses remain elusive. RESULTS: In the present study, we find that during C. albicans phagocytosis in macrophages, exocyst complex component 2 (SEC5) promotes InsP3 R channel activity by binding to its C-terminal α-helix (H1), increasing cytosolic Ca2+ concentrations ([Ca2+ ]c )...
April 27, 2018: BMC Biology
https://www.readbyqxmd.com/read/29703213/individual-odour-signatures-that-mice-learn-are-shaped-by-involatile-major-urinary-proteins-mups
#9
Sarah A Roberts, Mark C Prescott, Amanda J Davidson, Lynn McLean, Robert J Beynon, Jane L Hurst
BACKGROUND: Reliable recognition of individuals requires phenotypic identity signatures that are both individually distinctive and appropriately stable over time. Individual-specific vocalisations or visual patterning are well documented among birds and some mammals, whilst odours play a key role in social recognition across many vertebrates and invertebrates. Less well understood, though, is whether individuals are recognised through variation in cues that arise incidentally from a wide variety of genetic and non-genetic differences between individuals, or whether animals evolve distinctive polymorphic signals to advertise identity reliably...
April 27, 2018: BMC Biology
https://www.readbyqxmd.com/read/29703197/phylogenomics-resolves-the-evolutionary-chronicle-of-our-squirting-closest-relatives
#10
Gonzalo Giribet
A recent paper in BMC Biology has resolved the family relationships of sea squirts, one of our closest invertebrate relatives, by using a large phylogenomic data set derived from available genomes and newly generated transcriptomes. The work confirms previous ideas that ascidians (the sea squirts) are not monophyletic, as they include some pelagic jelly-like relatives, and proposes a chronogram for a group that has been difficult to resolve due to their accelerated genome evolution.See research article: https://bmcbiol...
April 27, 2018: BMC Biology
https://www.readbyqxmd.com/read/29690872/identification-of-a-neuronal-population-in-the-telencephalon-essential-for-fear-conditioning-in-zebrafish
#11
Pradeep Lal, Hideyuki Tanabe, Maximiliano L Suster, Deepak Ailani, Yuri Kotani, Akira Muto, Mari Itoh, Miki Iwasaki, Hironori Wada, Emre Yaksi, Koichi Kawakami
BACKGROUND: Fear conditioning is a form of learning essential for animal survival and used as a behavioral paradigm to study the mechanisms of learning and memory. In mammals, the amygdala plays a crucial role in fear conditioning. In teleost, the medial zone of the dorsal telencephalon (Dm) has been postulated to be a homolog of the mammalian amygdala by anatomical and ablation studies, showing a role in conditioned avoidance response. However, the neuronal populations required for a conditioned avoidance response via the Dm have not been functionally or genetically defined...
April 25, 2018: BMC Biology
https://www.readbyqxmd.com/read/29669603/genomics-analysis-of-aphanomyces-spp-identifies-a-new-class-of-oomycete-effector-associated-with-host-adaptation
#12
Elodie Gaulin, Michiel J C Pel, Laurent Camborde, Hélène San-Clemente, Sarah Courbier, Marie-Alexane Dupouy, Juliette Lengellé, Marine Veyssiere, Aurélie Le Ru, Frédéric Grandjean, Richard Cordaux, Bouziane Moumen, Clément Gilbert, Liliana M Cano, Jean-Marc Aury, Julie Guy, Patrick Wincker, Olivier Bouchez, Christophe Klopp, Bernard Dumas
BACKGROUND: Oomycetes are a group of filamentous eukaryotic microorganisms that have colonized all terrestrial and oceanic ecosystems, and they include prominent plant pathogens. The Aphanomyces genus is unique in its ability to infect both plant and animal species, and as such exemplifies oomycete versatility in adapting to different hosts and environments. Dissecting the underpinnings of oomycete diversity provides insights into their specificity and pathogenic mechanisms. RESULTS: By carrying out genomic analyses of the plant pathogen A...
April 18, 2018: BMC Biology
https://www.readbyqxmd.com/read/29669554/a-g-o-type-opsin-mediates-the-shadow-reflex-in-the-annelid-platynereis-dumerilii
#13
Thomas Ayers, Hisao Tsukamoto, Martin Gühmann, Vinoth Babu Veedin Rajan, Kristin Tessmar-Raible
BACKGROUND: The presence of photoreceptive molecules outside the eye is widespread among animals, yet their functions in the periphery are less well understood. Marine organisms, such as annelid worms, exhibit a 'shadow reflex', a defensive withdrawal behaviour triggered by a decrease in illumination. Herein, we examine the cellular and molecular underpinnings of this response, identifying a role for a photoreceptor molecule of the Go -opsin class in the shadow response of the marine bristle worm Platynereis dumerilii...
April 18, 2018: BMC Biology
https://www.readbyqxmd.com/read/29669552/developing-accurate-prediction-systems-for-the-terrestrial-environment
#14
David B Lindenmayer
In recent decades, meteorologists have made remarkable progress in predicting the weather, thereby saving lives and considerable sums of money. However, we are way behind when it comes to predicting the effects of environmental change on ecosystems, even when we are ourselves the agent of such change. Given the substantial environmental problems facing our living planet, and the need to tackle these in an ecologically responsible and cost-effective way, we should aspire to develop terrestrial environmental prediction systems that reach the levels of accuracy and precision which characterize weather prediction systems...
April 18, 2018: BMC Biology
https://www.readbyqxmd.com/read/29661185/madagascar-ground-gecko-genome-analysis-characterizes-asymmetric-fates-of-duplicated-genes
#15
Yuichiro Hara, Miki Takeuchi, Yuka Kageyama, Kaori Tatsumi, Masahiko Hibi, Hiroshi Kiyonari, Shigehiro Kuraku
BACKGROUND: Conventionally, comparison among amniotes - birds, mammals, and reptiles - has often been approached through analyses of mammals and, for comparison, birds. However, birds are morphologically and physiologically derived and, moreover, some parts of their genomes are recognized as difficult to sequence and/or assemble and are thus missing in genome assemblies. Therefore, sequencing the genomes of reptiles would aid comparative studies on amniotes by providing more comprehensive coverage to help understand the molecular mechanisms underpinning evolutionary changes...
April 16, 2018: BMC Biology
https://www.readbyqxmd.com/read/29653534/a-phylogenomic-framework-and-timescale-for-comparative-studies-of-tunicates
#16
Frédéric Delsuc, Hervé Philippe, Georgia Tsagkogeorga, Paul Simion, Marie-Ka Tilak, Xavier Turon, Susanna López-Legentil, Jacques Piette, Patrick Lemaire, Emmanuel J P Douzery
BACKGROUND: Tunicates are the closest relatives of vertebrates and are widely used as models to study the evolutionary developmental biology of chordates. Their phylogeny, however, remains poorly understood, and to date, only the 18S rRNA nuclear gene and mitogenomes have been used to delineate the major groups of tunicates. To resolve their evolutionary relationships and provide a first estimate of their divergence times, we used a transcriptomic approach to build a phylogenomic dataset including all major tunicate lineages, consisting of 258 evolutionarily conserved orthologous genes from representative species...
April 13, 2018: BMC Biology
https://www.readbyqxmd.com/read/29642893/q-a-how-do-gene-regulatory-networks-control-environmental-responses-in-plants
#17
Ying Sun, José R Dinneny
A gene regulatory network (GRN) describes the hierarchical relationship between transcription factors, associated proteins, and their target genes. Studying GRNs allows us to understand how a plant's genotype and environment are integrated to regulate downstream physiological responses. Current efforts in plants have focused on defining the GRNs that regulate functions such as development and stress response and have been performed primarily in genetically tractable model plant species such as Arabidopsis thaliana...
April 11, 2018: BMC Biology
https://www.readbyqxmd.com/read/29636056/from-top-to-bottom-cell-polarity-in-hedgehog-and-wnt-trafficking
#18
REVIEW
Ana-Citlali Gradilla, David Sanchez-Hernandez, Lucy Brunt, Steffen Scholpp
Spatial organization of membrane domains within cells and cells within tissues is key to the development of organisms and the maintenance of adult tissue. Cell polarization is crucial for correct cell-cell signalling, which, in turn, promotes cell differentiation and tissue patterning. However, the mechanisms linking internal cell polarity to intercellular signalling are just beginning to be unravelled. The Hedgehog (Hh) and Wnt pathways are major directors of development and their malfunction can cause severe disorders like cancer...
April 10, 2018: BMC Biology
https://www.readbyqxmd.com/read/29609607/the-integrated-stress-response-regulates-bmp-signalling-through-effects-on-translation
#19
Elke Malzer, Caia S Dominicus, Joseph E Chambers, Jennifer A Dickens, Souradip Mookerjee, Stefan J Marciniak
BACKGROUND: Developmental pathways must be responsive to the environment. Phosphorylation of eIF2α enables a family of stress-sensing kinases to trigger the integrated stress response (ISR), which has pro-survival and developmental consequences. Bone morphogenetic proteins (BMPs) regulate multiple developmental processes in organisms from insects to mammals. RESULTS: Here we show in Drosophila that GCN2 antagonises BMP signalling through direct effects on translation and indirectly via the transcription factor crc (dATF4)...
April 3, 2018: BMC Biology
https://www.readbyqxmd.com/read/29598825/combined-flow-cytometry-and-high-throughput-image-analysis-for-the-study-of-essential-genes-in-caenorhabditis-elegans
#20
Blanca Hernando-Rodríguez, Annmary Paul Erinjeri, María Jesús Rodríguez-Palero, Val Millar, Sara González-Hernández, María Olmedo, Bettina Schulze, Ralf Baumeister, Manuel J Muñoz, Peter Askjaer, Marta Artal-Sanz
BACKGROUND: Advances in automated image-based microscopy platforms coupled with high-throughput liquid workflows have facilitated the design of large-scale screens utilising multicellular model organisms such as Caenorhabditis elegans to identify genetic interactions, therapeutic drugs or disease modifiers. However, the analysis of essential genes has lagged behind because lethal or sterile mutations pose a bottleneck for high-throughput approaches, and a systematic way to analyse genetic interactions of essential genes in multicellular organisms has been lacking...
March 29, 2018: BMC Biology
journal
journal
40550
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"