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Advanced Functional Materials

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https://www.readbyqxmd.com/read/30140193/intracellular-pathways-involved-in-bone-regeneration-triggered-by-recombinant-silk-silica-chimeras
#1
Zaira Martín-Moldes, Davoud Ebrahimi, Robyn Plowright, Nina Dinjaski, Carole C Perry, Markus J Buehler, David L Kaplan
Biomineralization at the organic-inorganic interface is critical to many biology material functions in vitro and in vivo . Recombinant silk-silica fusion peptides are organic-inorganic hybrid material systems that can be effectively used to study and control biologically-mediated mineralization due to the genetic basis of sequence control. However, to date, the mechanisms by which these functionalized silk-silica proteins trigger the differentiation of human mesenchymal stem cells (hMSCs) to osteoblasts remain unknown...
July 4, 2018: Advanced Functional Materials
https://www.readbyqxmd.com/read/30416415/hybrid-paper-plastic-microchip-for-flexible-and-high-performance-point-of-care-diagnostics
#2
Mohamed Shehata Draz, Maryam Moazeni, Manasa Venkataramani, Harini Lakshminarayanan, Ecem Saygili, Nivethitha Kota Lakshminaraasimulu, Kamyar Mehrabi Kochehbyoki, Manoj Kumar Kanakasabapathy, Shirin Shabahang, Anish Vasan, Mohamad Ali Bijarchi, Adnan Memic, Hadi Shafiee
A low-cost and easy-to-fabricate microchip remains a key challenge for the development of true point-of-care (POC) diagnostics. Cellulose paper and plastic are thin, light, flexible, and abundant raw materials, which make them excellent substrates for mass production of POC devices. Herein, a hybrid paper-plastic microchip (PPMC) is developed, which can be used for both single and multiplexed detection of different targets, providing flexibility in the design and fabrication of the microchip. The developed PPMC with printed electronics is evaluated for sensitive and reliable detection of a broad range of targets, such as liver and colon cancer protein biomarkers, intact Zika virus, and human papillomavirus nucleic acid amplicons...
June 27, 2018: Advanced Functional Materials
https://www.readbyqxmd.com/read/30319322/remote-loaded-platelet-vesicles-for-disease-targeted-delivery-of-therapeutics
#3
Man Ying, Jia Zhuang, Xiaoli Wei, Xinxin Zhang, Yue Zhang, Yao Jiang, Diana Dehaini, Mengchun Chen, Silun Gu, Weiwei Gao, Weiyue Lu, Ronnie H Fang, Liangfang Zhang
The recent emergence of biomimetic nanotechnology has facilitated the development of next-generation nanodelivery systems capable of enhanced biointerfacing. In particular, the direct use of natural cell membranes can enable multivalent targeting functionalities. Herein, we report on the remote loading of small molecule therapeutics into cholesterol-enriched platelet membrane-derived vesicles for disease-targeted delivery. Using this approach, high loading yields for two model drugs, doxorubicin and vancomycin, are achieved...
May 30, 2018: Advanced Functional Materials
https://www.readbyqxmd.com/read/29875619/auxetic-cardiac-patches-with-tunable-mechanical-and-conductive-properties-toward-treating-myocardial-infarction
#4
Michaella Kapnisi, Catherine Mansfield, Camille Marijon, Anne Geraldine Guex, Filippo Perbellini, Ifigeneia Bardi, Eleanor J Humphrey, Jennifer L Puetzer, Damia Mawad, Demosthenes C Koutsogeorgis, Daniel J Stuckey, Cesare M Terracciano, Sian E Harding, Molly M Stevens
An auxetic conductive cardiac patch (AuxCP) for the treatment of myocardial infarction (MI) is introduced. The auxetic design gives the patch a negative Poisson's ratio, providing it with the ability to conform to the demanding mechanics of the heart. The conductivity allows the patch to interface with electroresponsive tissues such as the heart. Excimer laser microablation is used to micropattern a re-entrant honeycomb (bow-tie) design into a chitosan-polyaniline composite. It is shown that the bow-tie design can produce patches with a wide range in mechanical strength and anisotropy, which can be tuned to match native heart tissue...
May 24, 2018: Advanced Functional Materials
https://www.readbyqxmd.com/read/29785178/functionally-graded-bone-and-tendon-like-polyurethane-for-rotator-cuff-repair
#5
Dai Fei Elmer Ker, Dan Wang, Anthony William Behn, Evelyna Tsi Hsin Wang, Xu Zhang, Benjamin Yamin Zhou, Ángel Enrique Mercado-Pagán, Sungwoo Kim, John Kleimeyer, Burhan Gharaibeh, Yaser Shanjani, Drew Nelson, Marc Safran, Emilie Cheung, Phil Campbell, Yunzhi Peter Yang
Critical considerations in engineering biomaterials for rotator cuff repair include bone-tendon-like mechanical properties to support physiological loading and biophysicochemical attributes that stabilize the repair site over the long-term. In this study, UV-crosslinkable polyurethane based on quadrol (Q), hexamethylene diisocyante (H), and methacrylic anhydride (M; QHM polymers), which are free of solvent, catalyst, and photoinitiator, is developed. Mechanical characterization studies demonstrate that QHM polymers possesses phototunable bone- and tendon-like tensile and compressive properties (12-74 MPa tensile strength, 0...
May 2018: Advanced Functional Materials
https://www.readbyqxmd.com/read/29910700/protoporphyrin-ix-ppix-coated-superparamagnetic-iron-oxide-nanoparticle-spion-nanoclusters-for-magnetic-resonance-imaging-and-photodynamic-therapy
#6
Lesan Yan, Ahmad Amirshaghaghi, Dennis Huang, Joann Miller, Joel M Stein, Theresa M Busch, Zhiliang Cheng, Andrew Tsourkas
The ability to produce nanotherapeutics at large-scale with high drug loading efficiency, high drug loading capacity, high stability, and high potency is critical for clinical translation. However, many nanoparticle-based therapeutics under investigation suffer from complicated synthesis, poor reproducibility, low stability, and high cost. In this work, a simple method for preparing multifunctional nanoparticles is utilized that act as both a contrast agent for magnetic resonance imaging and a photosensitizer for photodynamic therapy for the treatment of cancer...
April 17, 2018: Advanced Functional Materials
https://www.readbyqxmd.com/read/29805350/a-materials-roadmap-to-functional-neural-interface-design
#7
Steven M Wellman, James R Eles, Kip A Ludwig, John P Seymour, Nicholas J Michelson, William E McFadden, Alberto L Vazquez, Takashi D Y Kozai
Advancement in neurotechnologies for electrophysiology, neurochemical sensing, neuromodulation, and optogenetics are revolutionizing scientific understanding of the brain while enabling treatments, cures, and preventative measures for a variety of neurological disorders. The grand challenge in neural interface engineering is to seamlessly integrate the interface between neurobiology and engineered technology, to record from and modulate neurons over chronic timescales. However, the biological inflammatory response to implants, neural degeneration, and long-term material stability diminish the quality of interface overtime...
March 21, 2018: Advanced Functional Materials
https://www.readbyqxmd.com/read/30271316/nanoparticle-based-fluoroionophore-for-analysis-of-potassium-ion-dynamics-in-3d-tissue-models-and-in-vivo
#8
Bernhard J Mueller, Alexander V Zhdanov, Sergey M Borisov, Tara Foley, Irina A Okkelman, Vassiliy Tsytsarev, Qinggong Tang, Reha S Erzurumlu, Yu Chen, Haijiang Zhang, Claudio Toncelli, Ingo Klimant, Dmitri B Papkovsky, Ruslan I Dmitriev
The imaging of real-time fluxes of K+ ions in live cell with high dynamic range (5-150 mM) is of paramount importance for neuroscience and physiology of the gastrointestinal tract, kidney and other tissues. In particular, the research on high-performance deep-red fluorescent nanoparticle-based biosensors is highly anticipated. We found that BODIPY-based FI3 K+ -sensitive fluoroionophore encapsulated in cationic polymer RL100 nanoparticles displays unusually strong efficiency in staining of broad spectrum of cell models, such as primary neurons and intestinal organoids...
February 28, 2018: Advanced Functional Materials
https://www.readbyqxmd.com/read/29785179/nanoformulation-of-brain-derived-neurotrophic-factor-with-target-receptor-triggered-release-in-the-central-nervous-system
#9
Yuhang Jiang, James M Fay, Chi-Duen Poon, Natasha Vinod, Yuling Zhao, Kristin Bullock, Si Qin, Devika S Manickam, Xiang Yi, William A Banks, Alexander V Kabanov
Brain-derived neurotrophic factor (BDNF) is identified as a potent neuroprotective and neuroregenerative agent for many neurological diseases. Regrettably, its delivery to the brain is hampered by poor serum stability and rapid brain clearance. Here, a novel nanoformulation is reported composed of a bio-compatible polymer, poly(ethylene glycol)- b -poly(L-glutamic acid) (PEG-PLE), that hosts the BDNF molecule in a nanoscale complex, termed here Nano-BDNF. Upon simple mixture, Nano-BDNF spontaneously forms uniform spherical particles with a core-shell structure...
February 7, 2018: Advanced Functional Materials
https://www.readbyqxmd.com/read/29706855/actively-targeted-deep-tissue-imaging-and-photothermal-chemo-therapy-of-breast-cancer-by-antibody-functionalized-drug-loaded-x-ray-responsive-bismuth-sulfide-mesoporous-silica-core-shell-nanoparticles
#10
Lihua Li, Yao Lu, Chunyan Jiang, Ye Zhu, Xianfeng Yang, Xiaoming Hu, Zefeng Lin, Yu Zhang, Mingying Peng, Hong Xia, Chuanbin Mao
A theranostic platform combining synergistic therapy and real-time imaging attracts enormous attention but still faces great challenges, such as tedious modifications and lack of efficient accumulation in tumor. Here, a novel type of theranostic agent, bismuth sulfide@mesoporous silica (Bi2 S3 @ mPS) core-shell nanoparticles (NPs), for targeted image-guided therapy of human epidermal growth factor receptor-2 (HER-2) positive breast cancer is developed. To generate such NPs, polyvinylpyrrolidone decorated rod-like Bi2 S3 NPs are chemically encapsulated with a mesoporous silica (mPS) layer and loaded with an anticancer drug, doxorubicin...
January 31, 2018: Advanced Functional Materials
https://www.readbyqxmd.com/read/30349427/thermogelling-abc-triblock-copolymer-platform-for-resorbable-hydrogels-with-tunable-degradation-mediated-drug-release
#11
Mukesh K Gupta, John R Martin, Bryan R Dollinger, Madison E Hattaway, Craig L Duvall
Clinical application of injectable, thermoresponsive hydrogels is hindered by lack of degradability and controlled drug release. To overcome these challenges, a family of thermoresponsive, ABC triblock polymer-based hydrogels has been engineered to degrade and release drug cargo through either oxidative or hydrolytic/enzymatic mechanisms dictated by the "A" block composition. Three ABC triblock copolymers are synthesized with varying "A" blocks, including oxidation-sensitive poly(propylene sulfide), slow hydrolytically/enzymatically degradable poly(ε-caprolactone), and fast hydrolytically/enzymatically degradable poly(D,L-lactide- co -glycolide), forming the respective formulations PPS135 - b -PDMA152 - b -PNIPAAM225 (PDN), PCL85 - b -PDMA150 - b -PNIPAAM150 (CDN), and PLGA60 - b -PDMA148 - b -PNIPAAM152 (LGDN)...
December 15, 2017: Advanced Functional Materials
https://www.readbyqxmd.com/read/29755309/targeted-delivery-of-crispr-cas9-mediated-cancer-gene-therapy-via-liposome-templated-hydrogel-nanoparticles
#12
Zeming Chen, Fuyao Liu, Yanke Chen, Jun Liu, Xiaoying Wang, Ann T Chen, Gang Deng, Hongyi Zhang, Jie Liu, Zhangyong Hong, Jiangbing Zhou
Due to its simplicity, versatility, and high efficiency, the clustered regularly interspaced short palindromic repeat (CRISPR)/Cas9 technology has emerged as one of the most promising approaches for treatment of a variety of genetic diseases, including human cancers. However, further translation of CRISPR/Cas9 for cancer gene therapy requires development of safe approaches for efficient, highly specific delivery of both Cas9 and single guide RNA to tumors. Here, novel core-shell nanostructure, liposome-templated hydrogel nanoparticles (LHNPs) that are optimized for efficient codelivery of Cas9 protein and nucleic acids is reported...
December 8, 2017: Advanced Functional Materials
https://www.readbyqxmd.com/read/29657571/ice-templated-protein-nanoridges-induce-bone-tissue-formation
#13
Mingying Yang, Yajun Shuai, Kegan S Sunderland, Chuanbin Mao
Little is known about the role of biocompatible protein nanoridges in directing stem cell fate and tissue regeneration due to the difficulty in forming protein nanoridges. Here an ice-templating approach is proposed to produce semi-parallel pure silk protein nanoridges. The key to this approach is that water droplets formed in the protein films are frozen into ice crystals (removed later by sublimation), pushing the surrounding protein molecules to be assembled into nanoridges. Unlike the flat protein films, the unique protein nanoridges can induce the differentiation of human mesenchymal stem cells (MSCs) into osteoblasts without any additional inducers, as well as the formation of bone tissue in a subcutaneous rat model even when not seeded with MSCs...
November 24, 2017: Advanced Functional Materials
https://www.readbyqxmd.com/read/29290753/tantalum-sulfide-nanosheets-as-a-theranostic-nanoplatform-for-computed-tomography-imaging-guided-combinatorial-chemo-photothermal-therapy
#14
Yanlan Liu, Xiaoyuan Ji, Jianhua Liu, Winnie W L Tong, Diana Askhatova, Jinjun Shi
Near-infrared (NIR)-absorbing metal-based nanomaterials have shown tremendous potential for cancer therapy, given their facile and controllable synthesis, efficient photothermal conversion, capability of spatiotemporal-controlled drug delivery, and intrinsic imaging function. Tantalum (Ta) is among the most biocompatible metals and arouses negligible adverse biological responses in either oxidized or reduced forms, and thus Ta-derived nanomaterials represent promising candidates for biomedical applications...
October 19, 2017: Advanced Functional Materials
https://www.readbyqxmd.com/read/28979182/glycine-n-methylation-in-ngr-tagged-nanocarriers-prevents-isoaspartate-formation-and-integrin-binding-without-impairing-cd13-recognition-and-tumor-homing
#15
Angelo Corti, Anna Maria Gasparri, Michela Ghitti, Angelina Sacchi, Francesco Sudati, Martina Fiocchi, Valentina Buttiglione, Laura Perani, Alessandro Gori, Silvia Valtorta, Rosa Maria Moresco, Fabio Pastorino, Mirco Ponzoni, Giovanna Musco, Flavio Curnis
NGR (asparagine-glycine-arginine) is a tumor vasculature-homing peptide motif widely used for the functionalization of drugs, nanomaterials and imaging compounds for cancer treatment and diagnosis. Unfortunately, this motif has a strong propensity to undergo rapid deamidation. This reaction, which converts NGR into isoDGR, is associated with receptor switching from CD13 to integrins, with potentially important manufacturing, pharmacological and toxicological implications. It is found that glycine N-methylation of NGR-tagged nanocarriers completely prevents asparagine deamidation without impairing CD13 recognition...
September 26, 2017: Advanced Functional Materials
https://www.readbyqxmd.com/read/29151826/renal-clearable-pegylated-porphyrin-nanoparticles-for-image-guided-photodynamic-cancer-therapy
#16
Liang Cheng, Dawei Jiang, Anyanee Kamkaew, Hector F Valdovinos, Hyung-Jun Im, Liangzhu Feng, Christopher G England, Shreya Goel, Todd E Barnhart, Zhuang Liu, Weibo Cai
Noninvasive dynamic positron emission tomography (PET) imaging was used to investigate the balance between renal clearance and tumor uptake behaviors of polyethylene glycol (PEG)-modified porphyrin nanoparticles (TCPP-PEG) with various molecular weights. TCPP-PEG10K nanoparticles with clearance behavior would be a good candidate for PET image-guided photodynamic therapy.
September 13, 2017: Advanced Functional Materials
https://www.readbyqxmd.com/read/29104526/-tissue-papers-from-organ-specific-decellularized-extracellular-matrices
#17
Adam E Jakus, Monica M Laronda, Alexandra S Rashedi, Christina M Robinson, Chris Lee, Sumanas W Jordan, Kyle E Orwig, Teresa K Woodruff, Ramille N Shah
Using an innovative, tissue-independent approach to decellularized tissue processing and biomaterial fabrication, the development of a series of "tissue papers" derived from native porcine tissues/organs (heart, kidney, liver, muscle), native bovine tissue/organ (ovary and uterus), and purified bovine Achilles tendon collagen as a control from decellularized extracellular matrix particle ink suspensions cast into molds is described. Each tissue paper type has distinct microstructural characteristics as well as physical and mechanical properties, is capable of absorbing up to 300% of its own weight in liquid, and remains mechanically robust ( E = 1-18 MPa) when hydrated; permitting it to be cut, rolled, folded, and sutured, as needed...
September 13, 2017: Advanced Functional Materials
https://www.readbyqxmd.com/read/29147108/muc1-aptamer-targeted-sers-nanoprobes
#18
Suchetan Pal, Stefan Harmsen, Anton Oseledchyk, Hsiao-Ting Hsu, Moritz F Kircher
Recently, surface-enhanced Raman scattering (SERS) nanoprobes (NPs) have shown promise in the field of cancer imaging due to their unparalleled signal specificity and high sensitivity. Here we report the development of a DNA aptamer targeted SERS NP. Recently, aptamers are being investigated as a viable alternative to more traditional antibody targeting due to their low immunogenicity and low cost of production. We developed a strategy to functionalize SERS NPs with DNA aptamers, which target Mucin1 (MUC1) in human breast cancer (BC)...
August 25, 2017: Advanced Functional Materials
https://www.readbyqxmd.com/read/29056886/multifunctional-molecular-beacon-micelles-for-intracellular-mrna-imaging-and-synergistic-therapy-in-multidrug-resistant-cancer-cells
#19
Ruili Zhang, Shi Gao, Zhongliang Wang, Da Han, Lin Liu, Qingjie Ma, Weihong Tan, Jie Tian, Xiaoyuan Chen
Multidrug resistance (MDR) resulting from overexpression of P-glycoprotein (Pgp) transporters increases the drug efflux and thereby limits the chemotherapeutic efficacy. It is desirable to administer both an MDR1 gene silencer and a chemotherapeutic agent in a sequential way to generate a synergistic therapeutic effect in multidrug-resistant cancer cells. Herein, we rationally designed an anti- MDR1 molecular beacon (MB)-based micelle (a-MBM) nanosystem, which is composed of a diacyllipid core densely packed with an MB corona...
August 18, 2017: Advanced Functional Materials
https://www.readbyqxmd.com/read/28747856/tunable-gas-sensing-gels-by-cooperative-assembly
#20
Abid Hussain, Ana T S Semeano, Susana I C J Palma, Ana S Pina, José Almeida, Bárbara F Medrado, Ana C C S Pádua, Ana L Carvalho, Madalena Dionísio, Rosamaria W C Li, Hugo Gamboa, Rein V Ulijn, Jonas Gruber, Ana C A Roque
The cooperative assembly of biopolymers and small molecules can yield functional materials with precisely tunable properties. Here, the fabrication, characterization, and use of multicomponent hybrid gels as selective gas sensors are reported. The gels are composed of liquid crystal droplets self-assembled in the presence of ionic liquids, which further coassemble with biopolymers to form stable matrices. Each individual component can be varied and acts cooperatively to tune gels' structure and function. The unique molecular environment in hybrid gels is explored for supramolecular recognition of volatile compounds...
July 19, 2017: Advanced Functional Materials
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