journal
https://read.qxmd.com/read/38465199/on-chip-reconstitution-of-uniformly-shear-sensing-3d-matrix-embedded-multicellular-blood-microvessel
#1
JOURNAL ARTICLE
Quoc Vo, Kaely A Carlson, Peter M Chiknas, Chad N Brocker, Luis DaSilva, Erica Clark, Sang Ki Park, A Seun Ajiboye, Eric M Wier, Kambez H Benam
Preclinical human-relevant modeling of organ-specific vasculature offers a unique opportunity to recreate pathophysiological intercellular, tissue-tissue, and cell-matrix interactions for a broad range of applications. Here, we present a reliable, and simply reproducible process for constructing user-controlled long rounded extracellular matrix (ECM)-embedded vascular microlumens on-chip for endothelization and co-culture with stromal cells obtained from human lung. We demonstrate the critical impact of microchannel cross-sectional geometry and length on uniform distribution and magnitude of vascular wall shear stress, which is key when emulating in vivo -observed blood flow biomechanics in health and disease...
March 4, 2024: Advanced Functional Materials
https://read.qxmd.com/read/38525448/a-highly-sensitive-and-long-term-stable-wearable-patch-for-continuous-analysis-of-biomarkers-in-sweat
#2
JOURNAL ARTICLE
Farnaz Lorestani, Xianzhe Zhang, Abu Musa Abdullah, Xin Xin, Yushen Liu, Mashfiqur Rahman, Md Abu Sayeed Biswas, Bowen Li, Ankan Dutta, Zhenyuan Niu, Shuvendu Das, Shishir Barai, Ke Wang, Huanyu Cheng
Although increasing efforts have been devoted to the development of non-invasive wearable or stretchable electrochemical sweat sensors for monitoring physiological and metabolic information, most of them still suffer from poor stability and specificity over time and fluctuating temperatures. This study reports the design and fabrication of a long-term stable and highly sensitive flexible electrochemical sensor based on nanocomposite-modified porous graphene by simple and facile laser treatment for detecting biomarkers such as glucose in sweat...
December 22, 2023: Advanced Functional Materials
https://read.qxmd.com/read/38495944/tunable-interparticle-connectivity-in-gold-nanosphere-assemblies-for-efficient-photoacoustic-conversion
#3
JOURNAL ARTICLE
Myeongsoo Kim, Jinhwan Kim, Don VanderLaan, Kelsey P Kubelick, Anamik Jhunjhunwala, Ayoung Choe, Stanislav Y Emelianov
Manipulating matter at the nanometer scale to create desired plasmonic nanostructures holds great promise in the field of biomedical photoacoustic (PA) imaging. We demonstrate a strategy for regulating PA signal generation from anisotropic nano-sized assemblies of gold nanospheres (Au NSs) by adjusting the inter-particle connectivity between neighboring Au NSs. The inter-particle connectivity is controlled by modulating the diameter and inter-particle spacing of Au NSs in the nanoassemblies. The results indicate that nanoassemblies with semi-connectivity, i...
December 15, 2023: Advanced Functional Materials
https://read.qxmd.com/read/38495320/low-field-actuating-magnetic-elastomer-membranes-characterized-using-fibre-optic-interferometry
#4
JOURNAL ARTICLE
Zhi Li, Joanna M Coote, Swathika Subburaman, Francesco Iacoviello, Kristopher Page, Erwin J Alles, Polina Prokopovich, Ivan P Parkin, Adrien E Desjardins, Sacha Noimark
Smart robotic devices remotely powered by magnetic field have emerged as versatile tools for wide biomedical applications. Soft magnetic elastomer (ME) composite membranes with high flexibility and responsiveness are frequently incorporated to enable local actuation for wireless sensing or cargo delivery. However, the fabrication of thin ME membranes with good control in geometry and uniformity remains challenging, as well as the optimization of their actuating performances under low fields (milli-Tesla). In this work, the development of ME membranes comprising of low-cost magnetic powder and highly soft elastomer through a simple template-assisted doctor blading approach, is reported...
December 8, 2023: Advanced Functional Materials
https://read.qxmd.com/read/38344241/protocells-capable-of-generating-a-cytoskeleton-like-structure-from-intracellular-membrane-active-artificial-organelles
#5
JOURNAL ARTICLE
Dishi Wang, Silvia Moreno, Mengfei Gao, Jiaqi Guo, Bing Xu, Brigitte Voit, Dietmar Appelhans
The intricate nature of eukaryotic cells with differently viscous intracellular compartments provides (membrane-active) enzymes to trigger time- and concentration-dependent processes in the intra-/extracellular matrix. Herein, we capitalize on membrane-active artificial organelles (AOs) to develop fluidic and stable proteinaceous membrane-based protocells. AOs in protocells induce the self-assembly of oligopeptides into an artificial cytoskeleton that underline their influence on the structure and functionality of protocells...
December 8, 2023: Advanced Functional Materials
https://read.qxmd.com/read/38144446/-in-vitro-prostate-cancer-treatment-via-crispr-cas9-gene-editing-facilitated-by-polyethyleneimine-derived-graphene-quantum-dots
#6
JOURNAL ARTICLE
Bong Lee, Klara Gries, Alina R Valimukhametova, Ryan L McKinney, Roberto Gonzalez-Rodriguez, Ugur C Topkiran, Jeffery Coffer, Giridhar R Akkaraju, Anton V Naumov
CRISPR-Cas9 is a programmable gene editing tool with a promising potential for cancer gene therapy. This therapeutic function is enabled in the present work via the non-covalent delivery of CRISPR ribonucleic protein (RNP) by cationic glucosamine/PEI-derived graphene quantum dots (PEI-GQD) that aid in overcoming physiological barriers and tracking genes of interest. PEI-GQD/RNP complex targeting the TP53 mutation overexpressed in ~50% of cancers successfully produces its double-stranded breaks in solution and in PC3 prostate cancer cells...
November 23, 2023: Advanced Functional Materials
https://read.qxmd.com/read/38464762/rapid-magnetically-directed-assembly-of-pre-patterned-capillary-scale-microvessels
#7
JOURNAL ARTICLE
Maggie E Jewett, Harrison L Hiraki, Michał Wojasiński, Zenghao Zhang, Susan S Xi, Amanda S Bluem, Eashan S Prabhu, William Y Wang, Abdon Pena-Francesch, Brendon M Baker
Capillary scale vascularization is critical to the survival of engineered 3D tissues and remains an outstanding challenge for the field of tissue engineering. Current methods to generate micro-scale vasculature such as 3D printing, two photon hydrogel ablation, angiogenesis, and vasculogenic assembly face challenges in rapidly creating organized, highly vascularized tissues at capillary length-scales. Within metabolically demanding tissues, native capillary beds are highly organized and densely packed to achieve adequate delivery of nutrients and oxygen and efficient waste removal...
October 2, 2023: Advanced Functional Materials
https://read.qxmd.com/read/37901180/in-drop-thermal-cycling-of-microcrystal-assembly-for-senescence-control-masc-with-minimal-variation-in-efficacy
#8
JOURNAL ARTICLE
Ryan C Miller, Jonghwi Lee, Young Jun Kim, Hee-Sun Han, Hyunjoon Kong
The secretome from mesenchymal stem cells (MSCs) has recently gained attention for new therapeutics. However, clinical application requires in vitro cell manufacturing to attain enough cells. Unfortunately, this process often drives MSCs into a senescent state that drastically changes cellular secretion activities. Antioxidants are used to reverse and prevent the propagation of senescence; however, their activity is short-lived. Polymer-stabilized crystallization of antioxidants has been shown to improve bioactivity, but the broad crystal size distribution (CSD) significantly increases the efficacy variation...
September 12, 2023: Advanced Functional Materials
https://read.qxmd.com/read/38131003/a-facile-strategy-for-the-fabrication-of-cell-laden-porous-alginate-hydrogels-based-on-two-phase-aqueous-emulsions
#9
JOURNAL ARTICLE
Wen Xue, Donghee Lee, Yunfan Kong, Mitchell Kuss, Ying Huang, Taesung Kim, Soonkyu Chung, Andrew T Dudley, Seung-Hyun Ro, Bin Duan
Porous alginate hydrogels possess many advantages as cell carriers. However, current pore generation methods require either complex or harsh fabrication processes, toxic components, or extra purification steps, limiting the feasibility and affecting the cellular survival and function. In this study, a simple and cell-friendly approach to generate highly porous cell-laden alginate hydrogels based on two-phase aqueous emulsions is reported. The pre-gel solutions, which contain two immiscible aqueous phases of alginate and caseinate, are crosslinked by calcium ions...
August 29, 2023: Advanced Functional Materials
https://read.qxmd.com/read/38046826/hydration-induced-void-containing-hydrogels-for-encapsulation-and-sustained-release-of-small-hydrophilic-molecules
#10
JOURNAL ARTICLE
Qi Li, Xiaosi Li, Elizabeth Bury, Amanda Koh, Kimberly Lackey, Ursula Wesselmann, Tony Yaksh, Chao Zhao
Efficient encapsulation and sustained release of small hydrophilic molecules from traditional hydrogel systems have been challenging due to the large mesh size of 3D networks and high water content. Furthermore, the encapsulated molecules are prone to early release from the hydrogel prior to use, resulting in a short shelf life of the formulation. Here, we present a hydration-induced void-containing hydrogel (HVH) based on hyperbranched polyglycerol-poly(propylene oxide)-hyperbranched polyglycerol (HPG-PPG-HPG) as a robust and efficient delivery system for small hydrophilic molecules...
August 22, 2023: Advanced Functional Materials
https://read.qxmd.com/read/37942189/amplification-of-cerenkov-luminescence-using-semiconducting-polymers-for-cancer-theranostics
#11
JOURNAL ARTICLE
Zachary T Rosenkrans, Jessica C Hsu, Eduardo Aluicio-Sarduy, Todd E Barnhart, Jonathan W Engle, Weibo Cai
The therapeutic efficacy of photodynamic therapy is limited by the ability of light to penetrate tissues. Due to this limitation, Cerenkov luminescence (CL) from radionuclides has recently been proposed as an alternative light source in a strategy referred to as Cerenkov radiation induced therapy (CRIT). Semiconducting polymer nanoparticles (SPNs) have ideal optical properties, such as large absorption cross-sections and broad absorbance, which can be utilized to harness the relatively weak CL produced by radionuclides...
August 15, 2023: Advanced Functional Materials
https://read.qxmd.com/read/37601745/simulation-of-cortical-and-cancellous-bone-to-accelerate-tissue-regeneration
#12
JOURNAL ARTICLE
Zhihai Fan, Hongxiang Liu, Zhaozhao Ding, Liying Xiao, Qiang Lu, David L Kaplan
Different tissues have complex anisotropic structures to support biological functions. Mimicking these complex structures in vitro remains a challenge in biomaterials designs in support of tissue regeneration. Here, inspired by different types of silk nanofibers, a composite materials strategy was pursued towards this challenge. A combination of fabrication methods was utilized to achieve separate control of amorphous and beta-sheet rich silk nanofibers in the same solution. Aqueous solutions containing these two structural types of silk nanofibers were then simultaneously treated with an electric field and with ethylene glycol diglycidyl ether (EGDE)...
August 15, 2023: Advanced Functional Materials
https://read.qxmd.com/read/38045635/gsh-activated-porphyrin-sonosensitizer-prodrug-for-fluorescence-imaging-guided-cancer-sonodynamic-therapy
#13
JOURNAL ARTICLE
Caiting Deng, Meichen Zheng, Shupeng Han, Yuanjie Wang, Jingqi Xin, Omer Aras, Liang Cheng, Feifei An
Sonodynamic therapy (SDT), which uses ultrasound to trigger a sonosensitizer to generate reactive oxygen species (ROS), is a promising form of cancer therapy with outstanding tissue penetration depth. However, the sonosensitizer may inevitably spread to surrounding healthy tissue beyond the tumor, resulting in undesired side effects under an ultrasound stimulus. Herein, as glutathione (GSH) is overexpressed in the tumor microenvironment, a GSH-activatable sonosensitizer prodrug was designed by attaching a quencher to tetraphydroxy porphyrin for tumor therapy...
August 8, 2023: Advanced Functional Materials
https://read.qxmd.com/read/38107427/hybrid-shear-thinning-hydrogel-integrating-hyaluronic-acid-with-ros-responsive-nanoparticles
#14
JOURNAL ARTICLE
Mariah G Bezold, Andrew R Hanna, Bryan R Dollinger, Prarthana Patil, Fang Yu, Craig L Duvall, Mukesh K Gupta
Nanoparticle (NP) supra-assembly offers unique opportunities to tune macroscopic hydrogels' mechanical strength, material degradation, and drug delivery properties. Here, synthetic, reactive oxygen species (ROS)-responsive NPs are physically crosslinked with hyaluronic acid (HA) through guest-host chemistry to create shear-thinning NP/HA hydrogels. A library of triblock copolymers composed of poly(propylene sulfide)- bl -poly(N,N-dimethylacrylamide)- bl -poly(N,N-dimethylacrylamide- co -N-(1-adamantyl)acrylamide) are synthesized with varied triblock architectures and adamantane grafting densities and then self-assembled into NPs displaying adamantane on their corona...
August 1, 2023: Advanced Functional Materials
https://read.qxmd.com/read/37873031/an-activity-based-nanosensor-for-minimally-invasive-measurement-of-protease-activity-in-traumatic-brain-injury
#15
JOURNAL ARTICLE
Julia A Kudryashev, Marianne I Madias, Rebecca M Kandell, Queenie X Lin, Ester J Kwon
Current screening and diagnostic tools for traumatic brain injury (TBI) have limitations in sensitivity and prognostication. Aberrant protease activity is a central process that drives disease progression in TBI and is associated with worsened prognosis; thus direct measurements of protease activity could provide more diagnostic information. In this study, a nanosensor is engineered to release a measurable signal into the blood and urine in response to activity from the TBI-associated protease calpain. Readouts from the nanosensor were designed to be compatible with ELISA and lateral flow assays, clinically-relevant assay modalities...
July 11, 2023: Advanced Functional Materials
https://read.qxmd.com/read/37810281/additive-manufacturing-of-engineered-living-materials-with-bio-augmented-mechanical-properties-and-resistance-to-degradation
#16
JOURNAL ARTICLE
Gokce Altin-Yavuzarslan, Sierra M Brooks, Shuo-Fu Yuan, James O Park, Hal S Alper, Alshakim Nelson
Engineered living materials (ELMs) combine living cells with polymeric matrices to yield unique materials with programmable functions. While the cellular platform and the polymer network determine the material properties and applications, there are still gaps in our ability to seamlessly integrate the biotic (cellular) and abiotic (polymer) components into singular material, then assemble them into devices and machines. Herein, we demonstrated the additive-manufacturing of ELMs wherein bioproduction of metabolites from the encapsulated cells enhanced the properties of the surrounding matrix...
June 12, 2023: Advanced Functional Materials
https://read.qxmd.com/read/37293509/cholesteric-liquid-crystal-polymeric-coatings-for-colorful-artificial-muscles-and-motile-humidity-sensor-skin-integrated-with-magnetic-composites
#17
JOURNAL ARTICLE
Wei Feng, Aniket Pal, Tianlu Wang, Ziyu Ren, Yingbo Yan, Yanqing Lu, Huai Yang, Metin Sitti
Structural colorful cholesterics show impressive susceptibility to external stimulation, leading to applications in electro/mechano-chromic devices. However, out-of-plane actuation of structural colorful actuators based on cholesterics and the integration with other stimulation remains underdeveloped. Herein, colorful actuators and motile humidity sensors are developed using humidity-responsive cholesteric liquid crystal networks (CLCNs) and magnetic composites. The developed colorful actuator can exhibit synergistic out-of-plane shape morphing and color change in response to humidity, with CLCNs as colorful artificial muscles...
June 2023: Advanced Functional Materials
https://read.qxmd.com/read/37200959/sputtered-l-1-0-fepd-and-its-synthetic-antiferromagnet-on-si-sio-2-wafers-for-scalable-spintronics
#18
JOURNAL ARTICLE
Deyuan Lyu, Jenae E Shoup, Dingbin Huang, Javier García-Barriocanal, Qi Jia, William Echtenkamp, Geoffrey A Rojas, Guichuan Yu, Brandon R Zink, Xiaojia Wang, Daniel B Gopman, Jian-Ping Wang
As a promising alternative to the mainstream CoFeB/MgO system with interfacial perpendicular magnetic anisotropy (PMA), L 10 -FePd and its synthetic antiferromagnet (SAF) structure with large crystalline PMA can support spintronic devices with sufficient thermal stability at sub-5 nm sizes. However, the compatibility requirement of preparing L 10 -FePd thin films on Si/SiO2 wafers is still unmet. In this paper, we prepare high-quality L 10 -FePd and its SAF on Si/SiO2 wafers by coating the amorphous SiO2 surface with an MgO(001) seed layer...
May 2023: Advanced Functional Materials
https://read.qxmd.com/read/37576949/molecular-engineering-of-cyclic-azobenzene-peptide-hybrid-ligands-for-the-purification-of-human-blood-factor-viii-via-photo-affinity-chromatography
#19
JOURNAL ARTICLE
Raphael Prodromou, Brandyn Moore, Wenning Chu, Halston Deal, Adriana San Miguel, Ashley C Brown, Michael A Daniele, Vladimir Pozdin, Stefano Menegatti
The use of benign stimuli to control the binding and release of labile biologics for their isolation from complex feedstocks is a key goal of modern biopharmaceutical technology. This study introduces cyclic azobenzene-peptide (CAP) hybrid ligands for the rapid and discrete photo-responsive capture and release of blood coagulation Factor VIII (FVIII). A predictive method - based on amino acid sequence and molecular architecture of CAPs - was developed to correlate the conformation of cis/trans CAP photo-isomers to FVIII binding and release...
April 4, 2023: Advanced Functional Materials
https://read.qxmd.com/read/37090954/deep-eutectic-solvents-based-ionogels-with-ultrafast-gelation-and-high-adhesion-in-harsh-environments
#20
JOURNAL ARTICLE
Gang Ge, Kalpana Mandal, Reihaneh Haghniaz, Mengchen Li, Xiao Xiao, Larry Carlson, Vadim Jucaud, Mehmet Remzi Dokmeci, Ghim Wei Ho, Ali Khademhosseini
Adhesive materials have recently drawn intensive attention due to their excellent sealing ability, thereby stimulating advances in materials science and industrial usage. However, reported adhesives usually exhibit weak adhesion strength, require high pressure for strong bonding, and display severe adhesion deterioration in various harsh environments. In this work, instead of water or organic solvents, a deep eutectic solution (DES) was used as the medium for photopolymerization of zwitterionic and polarized monomers, thus generating a novel ionogel with tunable mechanical properties...
February 23, 2023: Advanced Functional Materials
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