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Advanced Functional Materials

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https://www.readbyqxmd.com/read/28979182/glycine-n-methylation-in-ngr-tagged-nanocarriers-prevents-isoaspartate-formation-and-integrin-binding-without-impairing-cd13-recognition-and-tumor-homing
#1
Angelo Corti, Anna Maria Gasparri, Michela Ghitti, Angelina Sacchi, Francesco Sudati, Martina Fiocchi, Valentina Buttiglione, Laura Perani, Alessandro Gori, Silvia Valtorta, Rosa Maria Moresco, Fabio Pastorino, Mirco Ponzoni, Giovanna Musco, Flavio Curnis
NGR (asparagine-glycine-arginine) is a tumor vasculature-homing peptide motif widely used for the functionalization of drugs, nanomaterials and imaging compounds for cancer treatment and diagnosis. Unfortunately, this motif has a strong propensity to undergo rapid deamidation. This reaction, which converts NGR into isoDGR, is associated with receptor switching from CD13 to integrins, with potentially important manufacturing, pharmacological and toxicological implications. It is found that glycine N-methylation of NGR-tagged nanocarriers completely prevents asparagine deamidation without impairing CD13 recognition...
September 26, 2017: Advanced Functional Materials
https://www.readbyqxmd.com/read/28747856/tunable-gas-sensing-gels-by-cooperative-assembly
#2
Abid Hussain, Ana T S Semeano, Susana I C J Palma, Ana S Pina, José Almeida, Bárbara F Medrado, Ana C C S Pádua, Ana L Carvalho, Madalena Dionísio, Rosamaria W C Li, Hugo Gamboa, Rein V Ulijn, Jonas Gruber, Ana C A Roque
The cooperative assembly of biopolymers and small molecules can yield functional materials with precisely tunable properties. Here, the fabrication, characterization, and use of multicomponent hybrid gels as selective gas sensors are reported. The gels are composed of liquid crystal droplets self-assembled in the presence of ionic liquids, which further coassemble with biopolymers to form stable matrices. Each individual component can be varied and acts cooperatively to tune gels' structure and function. The unique molecular environment in hybrid gels is explored for supramolecular recognition of volatile compounds...
July 19, 2017: Advanced Functional Materials
https://www.readbyqxmd.com/read/28989338/chemical-sensing-systems-that-utilize-soft-electronics-on-thin-elastomeric-substrates-with-open-cellular-designs
#3
Yoon Kyeung Lee, Kyung-In Jang, Yinji Ma, Ahyeon Koh, Hang Chen, Han Na Jung, Yerim Kim, Jean Won Kwak, Liang Wang, Yeguang Xue, Yiyuan Yang, Wenlong Tian, Yu Jiang, Yihui Zhang, Xue Feng, Yonggang Huang, John A Rogers
A collection of materials and device architectures are introduced for thin, stretchable arrays of ion sensors that mount on open cellular substrates to facilitate solution exchange for use in biointegrated electronics. The results include integration strategies and studies of fundamental characteristics in chemical sensing and mechanical response. The latter involves experimental measurements and theoretical simulations that establish important considerations in the design of low modulus, stretchable properties in cellular substrates, and in the realization of advanced capabilities in spatiotemporal mapping of chemicals' gradients...
March 3, 2017: Advanced Functional Materials
https://www.readbyqxmd.com/read/28989337/neuroendocrine-tumor-targeted-upconversion-nanoparticle-based-micelles-for-simultaneous-nir-controlled-combination-chemotherapy-and-photodynamic-therapy-and-fluorescence-imaging
#4
Guojun Chen, Renata Jaskula-Sztul, Corinne R Esquibel, Irene Lou, Qifeng Zheng, Ajitha Dammalapati, April Harrison, Kevin W Eliceiri, Weiping Tang, Herbert Chen, Shaoqin Gong
Although neuroendocrine tumors (NETs) are slow growing, they are frequently metastatic at the time of discovery and no longer amenable to curative surgery, emphasizing the need for the development of other treatments. In this study, multifunctional upconversion nanoparticle (UCNP)-based theranostic micelles are developed for NET-targeted and near-infrared (NIR)-controlled combination chemotherapy and photodynamic therapy (PDT), and bioimaging. The theranostic micelle is formed by individual UCNP functionalized with light-sensitive amphiphilic block copolymers poly(4,5-dimethoxy-2-nitrobenzyl methacrylate)-polyethylene glycol (PNBMA-PEG) and Rose Bengal (RB) photosensitizers...
February 23, 2017: Advanced Functional Materials
https://www.readbyqxmd.com/read/28507484/imaging-and-analysis-of-encapsulated-objects-through-self-assembled-electron-and-optically-transparent-graphene-oxide-membranes
#5
Alexander Yulaev, Alexey Lipatov, Annie Xi Lu, Alexander Sinitskii, Marina S Leite, Andrei Kolmakov
We demonstrate a technique for facile encapsulation and adhesion of micro- and nano objects on arbitrary substrates, stencils, and micro structured surfaces by ultrathin graphene oxide membranes via a simple drop casting of graphene oxide solution. A self-assembled encapsulating membrane forms during the drying process at the liquid-air and liquid-solid interfaces and consists of a water-permeable quasi-2D network of overlapping graphene oxide flakes. Upon drying and interlocking between the flakes, the encapsulating coating around the object becomes mechanically robust, chemically protective, and yet highly transparent to electrons and photons in a wide energy range, enabling microscopic and spectroscopic access to encapsulated objects...
January 23, 2017: Advanced Functional Materials
https://www.readbyqxmd.com/read/28713230/in-vivo-micro-ct-imaging-of-human-mesenchymal-stem-cells-labeled-with-gold-poly-l-lysine-nanocomplexes
#6
Taeho Kim, Nohyun Lee, Dian R Arifin, Irina Shats, Miroslaw Janowski, Piotr Walczak, Taeghwan Hyeon, Jeff W M Bulte
Developing in vivo cell tracking is an important prerequisite for further development of cell-based therapy. So far, few computed tomography (CT) cell tracking studies have been described due to its notoriously low sensitivity and lack of efficient labeling protocols. We present a simple method to render human mesenchymal stem cells (hMSCs) sufficiently radiopaque by complexing 40 nm citrate-stabilized gold nanoparticles (AuNPs) with poly-L-lysine (PLL) and rhodamine B isothiocyanate (RITC). AuNP-PLL-RITC labeling did not affect cellular viability, proliferation, or downstream cell differentiation into adipocytes and osteocytes...
January 19, 2017: Advanced Functional Materials
https://www.readbyqxmd.com/read/28626362/nanoporous-gold-biointerfaces-modifying-nanostructure-to-control-neural-cell-coverage-and-enhance-electrophysiological-recording-performance
#7
Christopher A R Chapman, Ling Wang, Hao Chen, Joshua Garrison, Pamela J Lein, Erkin Seker
Nanostructured neural interface coatings have significantly enhanced recording fidelity in both implantable and in vitro devices. As such, nano-porous gold (np-Au) has shown promise as a multifunctional neural interface coating due, in part, to its ability to promote nanostructure-mediated reduction in astrocytic surface coverage while not affecting neuronal coverage. The goal of this study is to provide insight into the mechanisms by which the np-Au nanostructure drives the differential response of neurons versus astrocytes in an in vitro model...
January 19, 2017: Advanced Functional Materials
https://www.readbyqxmd.com/read/28824357/advanced-functional-nanomaterials-for-theranostics
#8
Haoyuan Huang, Jonathan F Lovell
Nanoscale materials have been explored extensively as agents for therapeutic and diagnostic (i.e. theranostic) applications. Research efforts have shifted from exploring new materials in vitro to designing materials that function in more relevant animal disease models, thereby increasing potential for clinical translation. Current interests include non-invasive imaging of diseases, biomarkers and targeted delivery of therapeutic drugs. Here, we discuss some general design considerations of advanced theranostic materials and challenges of their use, from both diagnostic and therapeutic perspectives...
January 12, 2017: Advanced Functional Materials
https://www.readbyqxmd.com/read/28970775/engineered-elastomer-substrates-for-guided-assembly-of-complex-3d-mesostructures-by-spatially-nonuniform-compressive-buckling
#9
Kewang Nan, Haiwen Luan, Zheng Yan, Xin Ning, Yiqi Wang, Ao Wang, Juntong Wang, Mengdi Han, Matthew Chang, Kan Li, Yutong Zhang, Wen Huang, Yeguang Xue, Yonggang Huang, Yihui Zhang, John A Rogers
Approaches capable of creating three-dimensional (3D) mesostructures in advanced materials (device-grade semiconductors, electroactive polymers etc.) are of increasing interest in modern materials research. A versatile set of approaches exploits transformation of planar precursors into 3D architectures through the action of compressive forces associated with release of prestrain in a supporting elastomer substrate. Although a diverse set of 3D structures can be realized in nearly any class of material in this way, all previously reported demonstrations lack the ability to vary the degree of compression imparted to different regions of the 2D precursor, thus constraining the diversity of 3D geometries...
January 5, 2017: Advanced Functional Materials
https://www.readbyqxmd.com/read/28798658/miniaturized-battery-free-wireless-systems-for-wearable-pulse-oximetry
#10
Jeonghyun Kim, Philipp Gutruf, Antonio M Chiarelli, Seung Yun Heo, Kyoungyeon Cho, Zhaoqian Xie, Anthony Banks, Seungyoung Han, Kyung-In Jang, Jung Woo Lee, Kyu-Tae Lee, Xue Feng, Yonggang Huang, Monica Fabiani, Gabriele Gratton, Ungyu Paik, John A Rogers
Development of unconventional technologies for wireless collection, storage and analysis of quantitative, clinically relevant information on physiological status is of growing interest. Soft, biocompatible systems are widely regarded as important because they facilitate mounting on external (e.g. skin) and internal (e.g. heart, brain) surfaces of the body. Ultra-miniaturized, lightweight and battery-free devices have the potential to establish complementary options in bio-integration, where chronic interfaces (i...
January 5, 2017: Advanced Functional Materials
https://www.readbyqxmd.com/read/28729818/a-cooperative-copper-metal-organic-framework-hydrogel-system-improves-wound-healing-in-diabetes
#11
Jisheng Xiao, Siyu Chen, Ji Yi, Hao Zhang, Guillermo A Ameer
Chronic non-healing wounds remain a major clinical challenge that would benefit from the development of advanced, regenerative dressings that promote wound closure within a clinically relevant time frame. The use of copper ions has shown promise in wound healing applications possibly by promoting angiogenesis. However, reported treatments that use copper ions require multiple applications of copper salts or oxides to the wound bed, exposing the patient to potentially toxic levels of copper ions and resulting in variable outcomes...
January 5, 2017: Advanced Functional Materials
https://www.readbyqxmd.com/read/28717350/properties-of-native-high-density-lipoproteins-inspire-synthesis-of-actively-targeted-in-vivo-sirna-delivery-vehicles
#12
Kaylin M McMahon, Michael P Plebanek, C Shad Thaxton
Efficient systemic administration of therapeutic short interfering RNA (siRNA) is challenging. High-density lipoproteins (HDL) are natural in vivo RNA delivery vehicles. Specifically, native HDLs: 1) Load single-stranded RNA; 2) Are anionic, which requires charge reconciliation between the RNA and HDL, and 3) Actively target scavenger receptor type B-1 (SR-B1) to deliver RNA. Emphasizing these particular parameters, we employed templated lipoprotein particles (TLP), mimics of spherical HDLs, and self-assembled them with single-stranded complements of, presumably, any highly unmodified siRNA duplex pair after formulation with a cationic lipid...
November 15, 2016: Advanced Functional Materials
https://www.readbyqxmd.com/read/28413376/ferromagnetic-folded-electrode-composite-as-a-soft-interface-to-the-skin-for-long-term-electrophysiological-recording
#13
Kyung-In Jang, Han Na Jung, Jung Woo Lee, Sheng Xu, Yu Hao Liu, Yinji Ma, Jae-Woong Jeong, Young Min Song, Jeonghyun Kim, Bong Hun Kim, Anthony Banks, Jean Won Kwak, Yiyuan Yang, Dawei Shi, Zijun Wei, Xue Feng, Ungyu Paik, Yonggang Huang, Roozbeh Ghaffari, John A Rogers
This paper introduces a class of ferromagnetic, folded, soft composite material for skin-interfaced electrodes with releasable interfaces to stretchable, wireless electronic measurement systems. These electrodes establish intimate, adhesive contacts to the skin, in dimensionally stable formats compatible with multiple days of continuous operation, with several key advantages over conventional hydrogel based alternatives. The reported studies focus on aspects ranging from ferromagnetic and mechanical behavior of the materials systems, to electrical properties associated with their skin interface, to system-level integration for advanced electrophysiological monitoring applications...
October 25, 2016: Advanced Functional Materials
https://www.readbyqxmd.com/read/28603477/mesoporous-piezoelectric-polymer-composite-films-with-tunable-mechanical-modulus-for-harvesting-energy-from-liquid-pressure-fluctuation
#14
Zhiyi Zhang, Chunhua Yao, Yanhao Yu, Zhanglian Hong, Mingjia Zhi, Xudong Wang
Harvesting mechanical energy from biological systems possesses great potential for in vivo powering implantable electronic devices. In this paper, a development of flexible piezoelectric nanogenerator (NG) is reported based on mesoporous poly(vinylidene fluoride) (PVDF) films. Monolithic mesoporous PVDF is fabricated by a template-free sol-gel-based approach at room temperature. By filling the pores of PVDF network with poly(dimethylsiloxane) (PDMS) elastomer, the composite's modulus is effectively tuned over a wide range down to the same level of biological systems...
October 4, 2016: Advanced Functional Materials
https://www.readbyqxmd.com/read/27942257/multi-material-tissue-engineering-scaffold-with-hierarchical-pore-architecture
#15
Kathy Ye Morgan, Demetra Sklaviadis, Zachary L Tochka, Kristin M Fischer, Keith Hearon, Thomas D Morgan, Robert Langer, Lisa E Freed
Multi-material polymer scaffolds with multiscale pore architectures were characterized and tested with vascular and heart cells as part of a platform for replacing damaged heart muscle. Vascular and muscle scaffolds were constructed from a new material, poly(limonene thioether) (PLT32i), which met the design criteria of slow biodegradability, elastomeric mechanical properties, and facile processing. The vascular-parenchymal interface was a poly(glycerol sebacate) (PGS) porous membrane that met different criteria of rapid biodegradability, high oxygen permeance, and high porosity...
August 23, 2016: Advanced Functional Materials
https://www.readbyqxmd.com/read/28824356/dissociated-and-reconstituted-cartilage-microparticles-in-densified-collagen-induce-local-hmsc-differentiation
#16
Tyler Novak, Benjamin Seelbinder, Celina M Twitchell, Sherry L Voytik-Harbin, Corey P Neu
Decellularized cartilage microparticles, and all associated native signals, are delivered to hMSC populations in a dense, type I collagen matrix. Hybrid usage of native tissue signals and the engineering control of collagen matrices show the ability to induce local infiltration and differentiation of hMSCs. Additionally, the solid cartilage microparticles inhibit bulk cell-mediated contraction of the composite.
August 9, 2016: Advanced Functional Materials
https://www.readbyqxmd.com/read/29033714/design-of-strain-limiting-substrate-materials-for-stretchable-and-flexible-electronics
#17
Yinji Ma, Kyung-In Jang, Liang Wang, Han Na Jung, Jean Won Kwak, Yeguang Xue, Hang Chen, Yiyuan Yang, Dawei Shi, Xue Feng, John A Rogers, Yonggang Huang
Recently developed classes of electronics for biomedical applications exploit substrates that offer low elastic modulus and high stretchability, to allow intimate, mechanically biocompatible integration with soft biological tissues. A challenge is that such substrates do not generally offer protection of the electronics from high peak strains that can occur upon large-scale deformation, thereby creating a potential for device failure. The results presented here establish a simple route to compliant substrates with strain-limiting mechanics based on approaches that complement those of recently described alternatives...
August 2, 2016: Advanced Functional Materials
https://www.readbyqxmd.com/read/27746710/graphene-nanopores-for-protein-sequencing
#18
James Wilson, Leila Sloman, Zhiren He, Aleksei Aksimentiev
An inexpensive, reliable method for protein sequencing is essential to unraveling the biological mechanisms governing cellular behavior and disease. Current protein sequencing methods suffer from limitations associated with the size of proteins that can be sequenced, the time, and the cost of the sequencing procedures. Here, we report the results of all-atom molecular dynamics simulations that investigated the feasibility of using graphene nanopores for protein sequencing. We focus our study on the biologically significant phenylalanine-glycine repeat peptides (FG-nups)-parts of the nuclear pore transport machinery...
July 19, 2016: Advanced Functional Materials
https://www.readbyqxmd.com/read/28670244/design-of-multistimuli-responsive-hydrogels-using-integrated-modeling-and-genetically-engineered-silk-elastin-like-proteins
#19
Wenwen Huang, Anna Tarakanova, Nina Dinjaski, Qin Wang, Xiaoxia Xia, Ying Chen, Joyce Y Wong, Markus J Buehler, David L Kaplan
Elastomeric, robust, and biocompatible hydrogels are rare, while the need for these types of biomaterials in biomedical-related uses remains high. Here, a new family of genetically engineered silk-elastin copolymers (SELPs) with encoded enzymatic crosslinking sites is developed for a new generation of stimuli-responsive yet robust hydrogels. Input into the designs is guided by simulation, and realized via genetic engineering strategies. The avoidance of gamma irradiation or chemical crosslinking during gel fabrication, in lieu of an enzymatic process, expands the versatility of these new gels for the incorporation of labile proteins and cells...
June 20, 2016: Advanced Functional Materials
https://www.readbyqxmd.com/read/28751853/tracking-and-quantification-of-magnetically-labeled-stem-cells-using-magnetic-resonance-imaging
#20
Forrest Goodfellow, Gregory A Simchick, Luke J Mortensen, Steven L Stice, Qun Zhao
Stem cell based therapies have critical impacts on treatments and cures of diseases such as neurodegenerative or cardiovascular disease. In vivo tracking of stem cells labeled with magnetic contrast agents is of particular interest and importance as it allows for monitoring of the cells' bio-distribution, viability, and physiological responses. Herein, recent advances are introduced in tracking and quantification of super-paramagnetic iron oxide (SPIO) nanoparticles-labeled cells with magnetic resonance imaging, a noninvasive approach that can longitudinally monitor transplanted cells...
June 14, 2016: Advanced Functional Materials
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