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Advanced Functional Materials

Alexander Yulaev, Alexey Lipatov, Annie Xi Lu, Alexander Sinitskii, Marina S Leite, Andrei Kolmakov
We demonstrate a technique for facile encapsulation and adhesion of micro- and nano objects on arbitrary substrates, stencils, and micro structured surfaces by ultrathin graphene oxide membranes via a simple drop casting of graphene oxide solution. A self-assembled encapsulating membrane forms during the drying process at the liquid-air and liquid-solid interfaces and consists of a water-permeable quasi-2D network of overlapping graphene oxide flakes. Upon drying and interlocking between the flakes, the encapsulating coating around the object becomes mechanically robust, chemically protective, and yet highly transparent to electrons and photons in a wide energy range, enabling microscopic and spectroscopic access to encapsulated objects...
January 23, 2017: Advanced Functional Materials
Christopher A R Chapman, Ling Wang, Hao Chen, Joshua Garrison, Pamela J Lein, Erkin Seker
Nanostructured neural interface coatings have significantly enhanced recording fidelity in both implantable and in vitro devices. As such, nano-porous gold (np-Au) has shown promise as a multifunctional neural interface coating due, in part, to its ability to promote nanostructure-mediated reduction in astrocytic surface coverage while not affecting neuronal coverage. The goal of this study is to provide insight into the mechanisms by which the np-Au nanostructure drives the differential response of neurons versus astrocytes in an in vitro model...
January 19, 2017: Advanced Functional Materials
Kyung-In Jang, Han Na Jung, Jung Woo Lee, Sheng Xu, Yu Hao Liu, Yinji Ma, Jae-Woong Jeong, Young Min Song, Jeonghyun Kim, Bong Hun Kim, Anthony Banks, Jean Won Kwak, Yiyuan Yang, Dawei Shi, Zijun Wei, Xue Feng, Ungyu Paik, Yonggang Huang, Roozbeh Ghaffari, John A Rogers
This paper introduces a class of ferromagnetic, folded, soft composite material for skin-interfaced electrodes with releasable interfaces to stretchable, wireless electronic measurement systems. These electrodes establish intimate, adhesive contacts to the skin, in dimensionally stable formats compatible with multiple days of continuous operation, with several key advantages over conventional hydrogel based alternatives. The reported studies focus on aspects ranging from ferromagnetic and mechanical behavior of the materials systems, to electrical properties associated with their skin interface, to system-level integration for advanced electrophysiological monitoring applications...
October 25, 2016: Advanced Functional Materials
Zhiyi Zhang, Chunhua Yao, Yanhao Yu, Zhanglian Hong, Mingjia Zhi, Xudong Wang
Harvesting mechanical energy from biological systems possesses great potential for in vivo powering implantable electronic devices. In this paper, a development of flexible piezoelectric nanogenerator (NG) is reported based on mesoporous poly(vinylidene fluoride) (PVDF) films. Monolithic mesoporous PVDF is fabricated by a template-free sol-gel-based approach at room temperature. By filling the pores of PVDF network with poly(dimethylsiloxane) (PDMS) elastomer, the composite's modulus is effectively tuned over a wide range down to the same level of biological systems...
October 4, 2016: Advanced Functional Materials
Kathy Ye Morgan, Demetra Sklaviadis, Zachary L Tochka, Kristin M Fischer, Keith Hearon, Thomas D Morgan, Robert Langer, Lisa E Freed
Multi-material polymer scaffolds with multiscale pore architectures were characterized and tested with vascular and heart cells as part of a platform for replacing damaged heart muscle. Vascular and muscle scaffolds were constructed from a new material, poly(limonene thioether) (PLT32i), which met the design criteria of slow biodegradability, elastomeric mechanical properties, and facile processing. The vascular-parenchymal interface was a poly(glycerol sebacate) (PGS) porous membrane that met different criteria of rapid biodegradability, high oxygen permeance, and high porosity...
August 23, 2016: Advanced Functional Materials
James Wilson, Leila Sloman, Zhiren He, Aleksei Aksimentiev
An inexpensive, reliable method for protein sequencing is essential to unraveling the biological mechanisms governing cellular behavior and disease. Current protein sequencing methods suffer from limitations associated with the size of proteins that can be sequenced, the time, and the cost of the sequencing procedures. Here, we report the results of all-atom molecular dynamics simulations that investigated the feasibility of using graphene nanopores for protein sequencing. We focus our study on the biologically significant phenylalanine-glycine repeat peptides (FG-nups)-parts of the nuclear pore transport machinery...
July 19, 2016: Advanced Functional Materials
Jing Huang, Yuancheng Li, Anamaria Orza, Qiong Lu, Peng Guo, Liya Wang, Lily Yang, Hui Mao
With rapid advances in nanomedicine, magnetic nanoparticles (MNPs) have emerged as a promising theranostic tool in biomedical applications, including diagnostic imaging, drug delivery and novel therapeutics. Significant preclinical and clinical research has explored their functionalization, targeted delivery, controllable drug release and image-guided capabilities. To further develop MNPs for theranostic applications and clinical translation in the future, we attempt to provide an overview of the recent advances in the development and application of MNPs for drug delivery, specifically focusing on the topics concerning the importance of biomarker targeting for personalized therapy and the unique magnetic and contrast-enhancing properties of theranostic MNPs that enable image-guided delivery...
June 14, 2016: Advanced Functional Materials
Jiao Wu, Xiang Wei, Jinrui Gan, Lin Huang, Ting Shen, Jiatao Lou, Baohong Liu, John X J Zhang, Kun Qian
We for the first time demonstrate multi-functional magnetic particles based rare cell isolation combined with the downstream laser desorption/ionization mass spectrometry (LDI-MS) to measure the metabolism of enriched circulating tumor cells (CTCs). The characterization of CTCs metabolism plays a significant role in understanding the tumor microenvironment, through exploring the diverse cellular process. However, characterizing cell metabolism is still challenging due to the low detection sensitivity, high sample complexity, and tedious preparation procedures, particularly for rare cells analysis in clinical study...
June 14, 2016: Advanced Functional Materials
Wujun Zhao, Taotao Zhu, Rui Cheng, Yufei Liu, Jian He, Hong Qiu, Lianchun Wang, Tamas Nagy, Troy D Querec, Elizabeth R Unger, Leidong Mao
In this study, a label-free, low-cost, and fast ferrohydrodynamic cell separation scheme is demonstrated using HeLa cells (an epithelial cell line) and red blood cells. The separation is based on cell size difference, and conducted in a custom-made biocompatible ferrofluid that retains the viability of cells during and after the assay for downstream analysis. The scheme offers moderate-throughput (≈10(6) cells h(-1) for a single channel device) and extremely high recovery rate (>99%) without the use of any label...
June 14, 2016: Advanced Functional Materials
Roozbeh Abedini-Nassab, Daniel Y Joh, Melissa Van Heest, Cody Baker, Ashutosh Chilkoti, David M Murdoch, Benjamin B Yellen
We demonstrate magnetophoretic conductor tracks that can transport single magnetized beads and magnetically labeled single cells in a 3-dimensional time-varying magnetic field. The vertical field bias, in addition to the in-plane rotating field, has the advantage of reducing the attraction between particles, which inhibits the formation of particle clusters. However, the inclusion of a vertical field requires the re-design of magnetic track geometries which can transport magnetized objects across the substrate...
June 14, 2016: Advanced Functional Materials
Christopher M Madl, Lily M Katz, Sarah C Heilshorn
Covalently-crosslinked hydrogels are commonly used as 3D matrices for cell culture and transplantation. However, the crosslinking chemistries used to prepare these gels generally cross-react with functional groups present on the cell surface, potentially leading to cytotoxicity and other undesired effects. Bio-orthogonal chemistries have been developed that do not react with biologically relevant functional groups, thereby preventing these undesirable side reactions. However, previously developed biomaterials using these chemistries still possess less than ideal properties for cell encapsulation, such as slow gelation kinetics and limited tuning of matrix mechanics and biochemistry...
June 7, 2016: Advanced Functional Materials
Wei Wei, Luigi Petrone, YerPeng Tan, Hao Cai, Jacob N Israelachvili, Ali Miserez, J Herbert Waite
Water hampers the formation of strong and durable bonds between adhesive polymers and solid surfaces, in turn hindering the development of adhesives for biomedical and marine applications. Inspired by mussel adhesion, a mussel foot protein homologue (mfp3S-pep) is designed, whose primary sequence is designed to mimic the pI, polyampholyte, and hydrophobic characteristics of the native protein. Noticeably, native protein and synthetic peptide exhibit similar abilities to self-coacervate at given pH and ionic strength...
May 24, 2016: Advanced Functional Materials
Rasa Ghaffarian, Edgar Pérez Herrero, Hyuntaek Oh, Srinivasa R Raghavan, Silvia Muro
When administered intravenously, active targeting of drug nanocarriers (NCs) improves biodistribution and endocytosis. Targeting may also improve oral delivery of NCs to treat gastrointestinal (GI) pathologies or for systemic absoption. However, GI instability of targeting moieties compromises this strategy. We explored whether encapsulation of antibody-coated NCs in microcapsules would protect against gastric degradation, providing NCs release and targeting in intestinal conditions. We used nanoparticles coated with antibodies against intercellular adhesion molecule-1 (anti-ICAM) or non-specific IgG...
May 24, 2016: Advanced Functional Materials
Yuan Liu, Zheng Yan, Qing Lin, Xuelin Guo, Mengdi Han, Kewang Nan, Keh-Chih Hwang, Yonggang Huang, Yihui Zhang, John A Rogers
Three-dimensional (3D) helical mesostructures are attractive for applications in a broad range of microsystem technologies, due to their mechanical and electromagnetic properties as stretchable interconnects, radio frequency antennas and others. Controlled compressive buckling of 2D serpentine-shaped ribbons provides a strategy to formation of such structures in wide ranging classes of materials (from soft polymers to brittle inorganic semiconductors) and length scales (from nanometer to centimeter), with an ability for automated, parallel assembly over large areas...
May 3, 2016: Advanced Functional Materials
Zheng Yan, Fan Zhang, Jiechen Wang, Fei Liu, Xuelin Guo, Kewang Nan, Qing Lin, Mingye Gao, Dongqing Xiao, Yan Shi, Yitao Qiu, Haiwen Luan, Jung Hwan Kim, Yiqi Wang, Hongying Luo, Mengdi Han, Yonggang Huang, Yihui Zhang, John A Rogers
Origami is a topic of rapidly growing interest in both the scientific and engineering research communities due to its promising potential in a broad range of applications. Previous assembly approaches of origami structures at the micro/nanoscale are constrained by the applicable classes of materials, topologies and/or capability of control over the transformation. Here, we introduce an approach that exploits controlled mechanical buckling for autonomic origami assembly of 3D structures across material classes from soft polymers to brittle inorganic semiconductors, and length scales from nanometers to centimeters...
April 25, 2016: Advanced Functional Materials
Tyler Novak, Benjamin Seelbinder, Celina M Twitchell, Corrinus C van Donkelaar, Sherry L Voytik-Harbin, Corey P Neu
Biological tissues and biomaterials are often defined by unique spatial gradients in physical properties that impart specialized function over hierarchical scales. The structure and organization of these materials forms continuous transitional gradients and discrete local microenvironments between adjacent (or within) tissues, and across matrix-cell boundaries, which can be difficult to replicate with common scaffold systems. Here, we studied the matrix densification of collagen leading to gradients in density, mechanical properties, and fibril morphology...
April 25, 2016: Advanced Functional Materials
Ki Su Kim, Hyemin Kim, Yunji Park, Won Ho Kong, Seung Woo Lee, Sheldon J J Kwok, Sei Kwang Hahn, Seok Hyun Yun
Vaccines are commonly administered by injection using needles. Although transdermal microneedles are less-invasive promising alternatives, needle-free topical vaccination without involving physical damage to the natural skin barrier is still sought after as it can further reduce needle-induced anxiety and simply administration. However, this long-standing goal has been elusive since the intact skin is impermeable to most macromolecules. Here, we show an efficient, non-invasive transdermal vaccination in mice by employing two key innovations: first, the use of hyaluronan (HA) as vaccine carriers and, second, non-ablative laser adjuvants...
April 19, 2016: Advanced Functional Materials
Liang Cheng, Sida Shen, Sixiang Shi, Yuan Yi, Xiaoyong Wang, Guosheng Song, Kai Yang, Gang Liu, Todd E Barnhart, Weibo Cai, Zhuang Liu
Multifunctional theranostic agents have become rather attractive to realize image-guided combination cancer therapy. Herein, we develop a novel method to synthesize Bi2Se3 nanosheets decorated with mono-dispersed FeSe2 nanoparticles (FeSe2/Bi2Se3) for tetra-modal image-guided combined photothermal & radiation tumor therapy. Interestingly, upon addition of Bi(NO3)3, pre-made FeSe2 nanoparticles via cation exchange would be gradually converted into Bi2Se3 nanosheets, on which remaining FeSe2 nanoparticles are decorated...
April 5, 2016: Advanced Functional Materials
Fei Wang, Ronnie H Fang, Brian T Luk, Che-Ming J Hu, Soracha Thamphiwatana, Diana Dehaini, Pavimol Angsantikul, Ashley V Kroll, Zhiqing Pang, Weiwei Gao, Weiyue Lu, Liangfang Zhang
With the rising threat of antibiotic-resistant bacteria, vaccination is becoming an increasingly important strategy to prevent and manage bacterial infections. Made from deactivated bacterial toxins, toxoid vaccines are widely used in the clinic as they help to combat the virulence mechanisms employed by different pathogens. Herein, the efficacy of a biomimetic nanoparticle-based anti-virulence vaccine is examined in a mouse model of methicillin-resistant Staphylococcus aureus (MRSA) skin infection. Vaccination with nanoparticle-detained staphylococcal α-hemolysin (Hla) effectively triggers the formation of germinal centers and induces high anti-Hla titers...
March 8, 2016: Advanced Functional Materials
Santiago Correa, Ki Young Choi, Erik C Dreaden, Kasper Renggli, Aria Shi, Li Gu, Kevin E Shopsowitz, Mohiuddin A Quadir, Elana Ben-Akiva, Paula T Hammond
Layer-by-layer (LbL) self-assembly is a versatile technique from which multicomponent and stimuli-responsive nanoscale drug carriers can be constructed. Despite the benefits of LbL assembly, the conventional synthetic approach for fabricating LbL nanoparticles requires numerous purification steps that limit scale, yield, efficiency, and potential for clinical translation. In this report, we describe a generalizable method for increasing throughput with LbL assembly by using highly scalable, closed-loop diafiltration to manage intermediate purification steps...
February 16, 2016: Advanced Functional Materials
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