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Advanced Functional Materials

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https://www.readbyqxmd.com/read/28747856/tunable-gas-sensing-gels-by-cooperative-assembly
#1
Abid Hussain, Ana T S Semeano, Susana I C J Palma, Ana S Pina, José Almeida, Bárbara F Medrado, Ana C C S Pádua, Ana L Carvalho, Madalena Dionísio, Rosamaria W C Li, Hugo Gamboa, Rein V Ulijn, Jonas Gruber, Ana C A Roque
The cooperative assembly of biopolymers and small molecules can yield functional materials with precisely tunable properties. Here, the fabrication, characterization, and use of multicomponent hybrid gels as selective gas sensors are reported. The gels are composed of liquid crystal droplets self-assembled in the presence of ionic liquids, which further coassemble with biopolymers to form stable matrices. Each individual component can be varied and acts cooperatively to tune gels' structure and function. The unique molecular environment in hybrid gels is explored for supramolecular recognition of volatile compounds...
July 19, 2017: Advanced Functional Materials
https://www.readbyqxmd.com/read/28507484/imaging-and-analysis-of-encapsulated-objects-through-self-assembled-electron-and-optically-transparent-graphene-oxide-membranes
#2
Alexander Yulaev, Alexey Lipatov, Annie Xi Lu, Alexander Sinitskii, Marina S Leite, Andrei Kolmakov
We demonstrate a technique for facile encapsulation and adhesion of micro- and nano objects on arbitrary substrates, stencils, and micro structured surfaces by ultrathin graphene oxide membranes via a simple drop casting of graphene oxide solution. A self-assembled encapsulating membrane forms during the drying process at the liquid-air and liquid-solid interfaces and consists of a water-permeable quasi-2D network of overlapping graphene oxide flakes. Upon drying and interlocking between the flakes, the encapsulating coating around the object becomes mechanically robust, chemically protective, and yet highly transparent to electrons and photons in a wide energy range, enabling microscopic and spectroscopic access to encapsulated objects...
January 23, 2017: Advanced Functional Materials
https://www.readbyqxmd.com/read/28713230/in-vivo-micro-ct-imaging-of-human-mesenchymal-stem-cells-labeled-with-gold-poly-l-lysine-nanocomplexes
#3
Taeho Kim, Nohyun Lee, Dian R Arifin, Irina Shats, Miroslaw Janowski, Piotr Walczak, Taeghwan Hyeon, Jeff W M Bulte
Developing in vivo cell tracking is an important prerequisite for further development of cell-based therapy. So far, few computed tomography (CT) cell tracking studies have been described due to its notoriously low sensitivity and lack of efficient labeling protocols. We present a simple method to render human mesenchymal stem cells (hMSCs) sufficiently radiopaque by complexing 40 nm citrate-stabilized gold nanoparticles (AuNPs) with poly-L-lysine (PLL) and rhodamine B isothiocyanate (RITC). AuNP-PLL-RITC labeling did not affect cellular viability, proliferation, or downstream cell differentiation into adipocytes and osteocytes...
January 19, 2017: Advanced Functional Materials
https://www.readbyqxmd.com/read/28626362/nanoporous-gold-biointerfaces-modifying-nanostructure-to-control-neural-cell-coverage-and-enhance-electrophysiological-recording-performance
#4
Christopher A R Chapman, Ling Wang, Hao Chen, Joshua Garrison, Pamela J Lein, Erkin Seker
Nanostructured neural interface coatings have significantly enhanced recording fidelity in both implantable and in vitro devices. As such, nano-porous gold (np-Au) has shown promise as a multifunctional neural interface coating due, in part, to its ability to promote nanostructure-mediated reduction in astrocytic surface coverage while not affecting neuronal coverage. The goal of this study is to provide insight into the mechanisms by which the np-Au nanostructure drives the differential response of neurons versus astrocytes in an in vitro model...
January 19, 2017: Advanced Functional Materials
https://www.readbyqxmd.com/read/28798658/miniaturized-battery-free-wireless-systems-for-wearable-pulse-oximetry
#5
Jeonghyun Kim, Philipp Gutruf, Antonio M Chiarelli, Seung Yun Heo, Kyoungyeon Cho, Zhaoqian Xie, Anthony Banks, Seungyoung Han, Kyung-In Jang, Jung Woo Lee, Kyu-Tae Lee, Xue Feng, Yonggang Huang, Monica Fabiani, Gabriele Gratton, Ungyu Paik, John A Rogers
Development of unconventional technologies for wireless collection, storage and analysis of quantitative, clinically relevant information on physiological status is of growing interest. Soft, biocompatible systems are widely regarded as important because they facilitate mounting on external (e.g. skin) and internal (e.g. heart, brain) surfaces of the body. Ultra-miniaturized, lightweight and battery-free devices have the potential to establish complementary options in bio-integration, where chronic interfaces (i...
January 5, 2017: Advanced Functional Materials
https://www.readbyqxmd.com/read/28729818/a-cooperative-copper-metal-organic-framework-hydrogel-system-improves-wound-healing-in-diabetes
#6
Jisheng Xiao, Siyu Chen, Ji Yi, Hao Zhang, Guillermo A Ameer
Chronic non-healing wounds remain a major clinical challenge that would benefit from the development of advanced, regenerative dressings that promote wound closure within a clinically relevant time frame. The use of copper ions has shown promise in wound healing applications possibly by promoting angiogenesis. However, reported treatments that use copper ions require multiple applications of copper salts or oxides to the wound bed, exposing the patient to potentially toxic levels of copper ions and resulting in variable outcomes...
January 5, 2017: Advanced Functional Materials
https://www.readbyqxmd.com/read/28717350/properties-of-native-high-density-lipoproteins-inspire-synthesis-of-actively-targeted-in-vivo-sirna-delivery-vehicles
#7
Kaylin M McMahon, Michael P Plebanek, C Shad Thaxton
Efficient systemic administration of therapeutic short interfering RNA (siRNA) is challenging. High-density lipoproteins (HDL) are natural in vivo RNA delivery vehicles. Specifically, native HDLs: 1) Load single-stranded RNA; 2) Are anionic, which requires charge reconciliation between the RNA and HDL, and 3) Actively target scavenger receptor type B-1 (SR-B1) to deliver RNA. Emphasizing these particular parameters, we employed templated lipoprotein particles (TLP), mimics of spherical HDLs, and self-assembled them with single-stranded complements of, presumably, any highly unmodified siRNA duplex pair after formulation with a cationic lipid...
November 15, 2016: Advanced Functional Materials
https://www.readbyqxmd.com/read/28413376/ferromagnetic-folded-electrode-composite-as-a-soft-interface-to-the-skin-for-long-term-electrophysiological-recording
#8
Kyung-In Jang, Han Na Jung, Jung Woo Lee, Sheng Xu, Yu Hao Liu, Yinji Ma, Jae-Woong Jeong, Young Min Song, Jeonghyun Kim, Bong Hun Kim, Anthony Banks, Jean Won Kwak, Yiyuan Yang, Dawei Shi, Zijun Wei, Xue Feng, Ungyu Paik, Yonggang Huang, Roozbeh Ghaffari, John A Rogers
This paper introduces a class of ferromagnetic, folded, soft composite material for skin-interfaced electrodes with releasable interfaces to stretchable, wireless electronic measurement systems. These electrodes establish intimate, adhesive contacts to the skin, in dimensionally stable formats compatible with multiple days of continuous operation, with several key advantages over conventional hydrogel based alternatives. The reported studies focus on aspects ranging from ferromagnetic and mechanical behavior of the materials systems, to electrical properties associated with their skin interface, to system-level integration for advanced electrophysiological monitoring applications...
October 25, 2016: Advanced Functional Materials
https://www.readbyqxmd.com/read/28603477/mesoporous-piezoelectric-polymer-composite-films-with-tunable-mechanical-modulus-for-harvesting-energy-from-liquid-pressure-fluctuation
#9
Zhiyi Zhang, Chunhua Yao, Yanhao Yu, Zhanglian Hong, Mingjia Zhi, Xudong Wang
Harvesting mechanical energy from biological systems possesses great potential for in vivo powering implantable electronic devices. In this paper, a development of flexible piezoelectric nanogenerator (NG) is reported based on mesoporous poly(vinylidene fluoride) (PVDF) films. Monolithic mesoporous PVDF is fabricated by a template-free sol-gel-based approach at room temperature. By filling the pores of PVDF network with poly(dimethylsiloxane) (PDMS) elastomer, the composite's modulus is effectively tuned over a wide range down to the same level of biological systems...
October 4, 2016: Advanced Functional Materials
https://www.readbyqxmd.com/read/27942257/multi-material-tissue-engineering-scaffold-with-hierarchical-pore-architecture
#10
Kathy Ye Morgan, Demetra Sklaviadis, Zachary L Tochka, Kristin M Fischer, Keith Hearon, Thomas D Morgan, Robert Langer, Lisa E Freed
Multi-material polymer scaffolds with multiscale pore architectures were characterized and tested with vascular and heart cells as part of a platform for replacing damaged heart muscle. Vascular and muscle scaffolds were constructed from a new material, poly(limonene thioether) (PLT32i), which met the design criteria of slow biodegradability, elastomeric mechanical properties, and facile processing. The vascular-parenchymal interface was a poly(glycerol sebacate) (PGS) porous membrane that met different criteria of rapid biodegradability, high oxygen permeance, and high porosity...
August 23, 2016: Advanced Functional Materials
https://www.readbyqxmd.com/read/27746710/graphene-nanopores-for-protein-sequencing
#11
James Wilson, Leila Sloman, Zhiren He, Aleksei Aksimentiev
An inexpensive, reliable method for protein sequencing is essential to unraveling the biological mechanisms governing cellular behavior and disease. Current protein sequencing methods suffer from limitations associated with the size of proteins that can be sequenced, the time, and the cost of the sequencing procedures. Here, we report the results of all-atom molecular dynamics simulations that investigated the feasibility of using graphene nanopores for protein sequencing. We focus our study on the biologically significant phenylalanine-glycine repeat peptides (FG-nups)-parts of the nuclear pore transport machinery...
July 19, 2016: Advanced Functional Materials
https://www.readbyqxmd.com/read/28670244/design-of-multistimuli-responsive-hydrogels-using-integrated-modeling-and-genetically-engineered-silk-elastin-like-proteins
#12
Wenwen Huang, Anna Tarakanova, Nina Dinjaski, Qin Wang, Xiaoxia Xia, Ying Chen, Joyce Y Wong, Markus J Buehler, David L Kaplan
Elastomeric, robust, and biocompatible hydrogels are rare, while the need for these types of biomaterials in biomedical-related uses remains high. Here, a new family of genetically engineered silk-elastin copolymers (SELPs) with encoded enzymatic crosslinking sites is developed for a new generation of stimuli-responsive yet robust hydrogels. Input into the designs is guided by simulation, and realized via genetic engineering strategies. The avoidance of gamma irradiation or chemical crosslinking during gel fabrication, in lieu of an enzymatic process, expands the versatility of these new gels for the incorporation of labile proteins and cells...
June 20, 2016: Advanced Functional Materials
https://www.readbyqxmd.com/read/28751853/tracking-and-quantification-of-magnetically-labeled-stem-cells-using-magnetic-resonance-imaging
#13
Forrest Goodfellow, Gregory A Simchick, Luke J Mortensen, Steven L Stice, Qun Zhao
Stem cell based therapies have critical impacts on treatments and cures of diseases such as neurodegenerative or cardiovascular disease. In vivo tracking of stem cells labeled with magnetic contrast agents is of particular interest and importance as it allows for monitoring of the cells' bio-distribution, viability, and physiological responses. Herein, recent advances are introduced in tracking and quantification of super-paramagnetic iron oxide (SPIO) nanoparticles-labeled cells with magnetic resonance imaging, a noninvasive approach that can longitudinally monitor transplanted cells...
June 14, 2016: Advanced Functional Materials
https://www.readbyqxmd.com/read/28663720/label-free-microfluidic-manipulation-of-particles-and-cells-in-magnetic-liquids
#14
Wujun Zhao, Rui Cheng, Joshua R Miller, Leidong Mao
Manipulating particles and cells in magnetic liquids through so-called "negative magnetophoresis" is a new research field. It has resulted in label-free and low-cost manipulation techniques in microfluidic systems and many exciting applications. It is the goal of this review to introduce the fundamental principles of negative magnetophoresis and its recent applications in microfluidic manipulation of particles and cells. We will first discuss the theoretical background of three commonly used specificities of manipulation in magnetic liquids, which include the size, density and magnetic property of particles and cells...
June 14, 2016: Advanced Functional Materials
https://www.readbyqxmd.com/read/27790080/magnetic-nanoparticle-facilitated-drug-delivery-for-cancer-therapy-with-targeted-and-image-guided-approaches
#15
Jing Huang, Yuancheng Li, Anamaria Orza, Qiong Lu, Peng Guo, Liya Wang, Lily Yang, Hui Mao
With rapid advances in nanomedicine, magnetic nanoparticles (MNPs) have emerged as a promising theranostic tool in biomedical applications, including diagnostic imaging, drug delivery and novel therapeutics. Significant preclinical and clinical research has explored their functionalization, targeted delivery, controllable drug release and image-guided capabilities. To further develop MNPs for theranostic applications and clinical translation in the future, we attempt to provide an overview of the recent advances in the development and application of MNPs for drug delivery, specifically focusing on the topics concerning the importance of biomarker targeting for personalized therapy and the unique magnetic and contrast-enhancing properties of theranostic MNPs that enable image-guided delivery...
June 14, 2016: Advanced Functional Materials
https://www.readbyqxmd.com/read/27524958/multifunctional-magnetic-particles-for-combined-circulating-tumor-cells-isolation-and-cellular-metabolism-detection
#16
Jiao Wu, Xiang Wei, Jinrui Gan, Lin Huang, Ting Shen, Jiatao Lou, Baohong Liu, John X J Zhang, Kun Qian
We for the first time demonstrate multi-functional magnetic particles based rare cell isolation combined with the downstream laser desorption/ionization mass spectrometry (LDI-MS) to measure the metabolism of enriched circulating tumor cells (CTCs). The characterization of CTCs metabolism plays a significant role in understanding the tumor microenvironment, through exploring the diverse cellular process. However, characterizing cell metabolism is still challenging due to the low detection sensitivity, high sample complexity, and tedious preparation procedures, particularly for rare cells analysis in clinical study...
June 14, 2016: Advanced Functional Materials
https://www.readbyqxmd.com/read/27478429/label-free-and-continuous-flow-ferrohydrodynamic-separation-of-hela-cells-and-blood-cells-in-biocompatible-ferrofluids
#17
Wujun Zhao, Taotao Zhu, Rui Cheng, Yufei Liu, Jian He, Hong Qiu, Lianchun Wang, Tamas Nagy, Troy D Querec, Elizabeth R Unger, Leidong Mao
In this study, a label-free, low-cost, and fast ferrohydrodynamic cell separation scheme is demonstrated using HeLa cells (an epithelial cell line) and red blood cells. The separation is based on cell size difference, and conducted in a custom-made biocompatible ferrofluid that retains the viability of cells during and after the assay for downstream analysis. The scheme offers moderate-throughput (≈10(6) cells h(-1) for a single channel device) and extremely high recovery rate (>99%) without the use of any label...
June 14, 2016: Advanced Functional Materials
https://www.readbyqxmd.com/read/27418922/magnetophoretic-conductors-and-diodes-in-a-3d-magnetic-field
#18
Roozbeh Abedini-Nassab, Daniel Y Joh, Melissa Van Heest, Cody Baker, Ashutosh Chilkoti, David M Murdoch, Benjamin B Yellen
We demonstrate magnetophoretic conductor tracks that can transport single magnetized beads and magnetically labeled single cells in a 3-dimensional time-varying magnetic field. The vertical field bias, in addition to the in-plane rotating field, has the advantage of reducing the attraction between particles, which inhibits the formation of particle clusters. However, the inclusion of a vertical field requires the re-design of magnetic track geometries which can transport magnetized objects across the substrate...
June 14, 2016: Advanced Functional Materials
https://www.readbyqxmd.com/read/28713229/slippery-liquid-infused-porous-surfaces-that-prevent-microbial-surface-fouling-and-kill-non-adherent-pathogens-in-surrounding-media-a-controlled-release-approach
#19
Uttam Manna, Namrata Raman, Michael A Welsh, Yashira M Zayas-Gonzalez, Helen E Blackwell, Sean P Palecek, David M Lynn
Many types of slippery liquid-infused porous surfaces (or 'SLIPS') can resist adhesion and colonization by microorganisms. These 'slippery' materials thus offer new approaches to prevent fouling on a range of commercial and industrial surfaces, including biomedical devices. However, while SLIPS can prevent fouling on surfaces to which they are applied, they can currently do little to prevent the proliferation of non-adherent (planktonic) organisms, stop them from colonizing other surfaces, or prevent them from engaging in other behaviors that could lead to infection and associated burdens...
June 7, 2016: Advanced Functional Materials
https://www.readbyqxmd.com/read/27642274/bio-orthogonally-crosslinked-engineered-protein-hydrogels-with-tunable-mechanics-and-biochemistry-for-cell-encapsulation
#20
Christopher M Madl, Lily M Katz, Sarah C Heilshorn
Covalently-crosslinked hydrogels are commonly used as 3D matrices for cell culture and transplantation. However, the crosslinking chemistries used to prepare these gels generally cross-react with functional groups present on the cell surface, potentially leading to cytotoxicity and other undesired effects. Bio-orthogonal chemistries have been developed that do not react with biologically relevant functional groups, thereby preventing these undesirable side reactions. However, previously developed biomaterials using these chemistries still possess less than ideal properties for cell encapsulation, such as slow gelation kinetics and limited tuning of matrix mechanics and biochemistry...
June 7, 2016: Advanced Functional Materials
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