Janin Edelkamp, Marta B Lousada, Daniela Pinto, Jérémy Chéret, James D B O'Sullivan, Antonio Biundo, Francisco Jimenez, Wolfgang Funk, Christian Roessing, Volker Rippmann, Ralf Paus, Marta Bertolini
INTRODUCTION: Several olfactory receptors (ORs) are expressed in human skin, where they regulate skin pigmentation, barrier function, wound healing, and hair growth. Previously, we found that the selective activation of OR family 2 subfamily AT member 4 (OR2AT4) by the synthetic, sandalwood-like odorant, Sandalore®, differentially stimulates the expression of antimicrobial peptides (AMPs) in human scalp hair follicle epithelium ex vivo. As OR2AT4 is also expressed by epidermal keratinocytes, we hypothesized that it may modulate intraepidermal AMP synthesis, thereby contributing to skin microbiome management...
January 26, 2023: Skin Pharmacology and Physiology