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Skin Pharmacology and Physiology

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https://www.readbyqxmd.com/read/28881348/accelerating-topical-anaesthesia-using-microneedles
#1
Lleucu B Davies, Christopher Gateley, Phillip Holland, Siôn A Coulman, James C Birchall
BACKGROUND/AIMS: Topical anaesthetics reduce pain during venous access procedures in children. However, clinical use is hindered by a significant anaesthetic onset time. Restricted diffusion of the topical anaesthetic through the stratum corneum barrier is the principal reason for the delayed onset. Microneedles can painlessly pierce the skin. This study evaluated microneedle pre-treatment of ex vivo human skin as a means to increase the rate of tetracaine permeation, in order to accelerate the onset of anaesthesia...
September 8, 2017: Skin Pharmacology and Physiology
https://www.readbyqxmd.com/read/28873377/sea-buckthorn-hippopha%C3%A3-rhamnoides-l-oil-improves-atopic-dermatitis-like-skin-lesions-via-inhibition-of-nf-%C3%AE%C2%BAb-and-stat1-activation
#2
Dian-Dong Hou, Zheng-Hong Di, Rui-Qun Qi, He-Xiao Wang, Song Zheng, Yu-Xiao Hong, Hao Guo, Hong-Duo Chen, Xing-Hua Gao
BACKGROUND AND OBJECTIVES: The objective of this study was to evaluate the topical effects of sea buckthorn (SBT) oil on atopic dermatitis (AD)-like lesions in a mouse model generated by repeated topical administration of DNCB in BALB/c mice. METHODS: DNCB was applied repeatedly on the dorsal skin of mice to induce AD-like lesions. Following AD induction, SBT oil was applied daily on the dorsal skin for 4 weeks. The severity of skin lesions was examined macroscopically and histologically...
September 6, 2017: Skin Pharmacology and Physiology
https://www.readbyqxmd.com/read/28803240/impact-of-body-site-age-and-gender-on-the-collagen-elastin-index-by-noninvasive-in-vivo-vertical-two-photon-microscopy
#3
Carolin Czekalla, Karl-Heinz Schönborn, Nadine Döge, Sora Jung, Maxim E Darvin, Jürgen Lademann, Martina C Meinke
BACKGROUND/AIMS: Extrinsic and intrinsic skin aging is subject to constant remodeling and degradation processes, primarily in components of the extracellular matrix. While collagen fibers thin out during the aging process, the amorphous elastin fibers accumulate. These are essential formative components of the dermis. So far, these processes have been detected in vertical histological sections of invasive biopsies and recently in noninvasive horizontal scans. METHODS: In this pilot study, a modified noninvasive 2-photon microscope was applied to measure the collagen/elastin index of skin in vivo...
August 12, 2017: Skin Pharmacology and Physiology
https://www.readbyqxmd.com/read/28746940/comparison-of-the-skin-penetration-of-3-metabolically-stable-chemicals-using-fresh-and-frozen-human-skin
#4
Carine Jacques-Jamin, Hélène Duplan, Helga Rothe, Ophelie Vaillant, Joan Eilstein, Sebastien Grégoire, Richard Cubberley, Daniela Lange, Corie Ellison, Martina Klaric, Nicola Hewitt, Andreas Schepky
BACKGROUND: The Cosmetics Europe ADME Task Force is developing in vitro and in silico tools for predicting skin and systemic concentrations after topical application of cosmetic ingredients. There are conflicting reports as to whether the freezing process affects the penetration of chemicals; therefore, we evaluated whether the storage of human skin used in our studies (8-12 weeks at -20°C) affected the penetration of model chemicals. METHODS: Finite doses of trans-cinnamic acid (TCA), benzoic acid (BA), and 6-methylcoumarin (6MC) (non-volatile, non-protein reactive and metabolically stable in skin) were applied to fresh and thawed frozen skin from the same donors...
July 27, 2017: Skin Pharmacology and Physiology
https://www.readbyqxmd.com/read/28746926/histamine-iontophoresis-as-in-vivo-model-to-study-human-skin-inflammation-with-minimal-barrier-impairment-pilot-study-results-of-application-of-the-model-to-a-sensitive-skin-panel
#5
Denise Falcone, Natallia Uzunbajakava, Renée Richters, Peter C M van de Kerkhof, Piet E J van Erp
BACKGROUND/AIMS: Histamine iontophoresis is known to elicit itch and a wheal-and-flare reaction; however, its impact on the skin barrier and underlying compartments has not been thoroughly evaluated yet. The primary objective of this study was to characterize that using immunohistochemistry, biophysical measurements, and image analysis, and secondly, to explore whether skin reactions to this model differ in sensitive skin (SS). METHODS: Eighteen healthy subjects, n = 9 with SS and n = 9 with non-sensitive skin (NSS), were included based on a perception-based questionnaire...
July 27, 2017: Skin Pharmacology and Physiology
https://www.readbyqxmd.com/read/28723689/a-randomized-controlled-trial-of-green-tea-beverages-on-the-in-vivo-radical-scavenging-activity-in-human-skin
#6
Inna Megow, Maxim E Darvin, Martina C Meinke, Jürgen Lademann
BACKGROUND: Oxidative stress plays an important role in the pathogenesis of various skin diseases. Thus, the antioxidant network of the skin relies on the uptake of exogenous antioxidants to ensure cell protection against radical formation. Green tea is one of the main sources of polyphenolic antioxidant compounds, but only few data are available on its cutaneous antioxidant effects. METHODS: The radical scavenging properties of Benifuuki and Yabukita green tea were investigated in the human skin...
July 20, 2017: Skin Pharmacology and Physiology
https://www.readbyqxmd.com/read/28704830/sirtuins-in-skin-and-skin-cancers
#7
Liz Mariely Garcia-Peterson, Melissa Jean Wilking-Busch, Mary Ann Ndiaye, Christine Gaby Azer Philippe, Vijayasaradhi Setaluri, Nihal Ahmad
The sirtuins are a family of proteins that comprise class III of the histone deacetylases. These NAD+-dependent proteins have been found to be intricately involved in a variety of important and skin-relevant cellular functions and processes, including aging, UV damage response, oxidative stress, and wound repair. In addition, recent research is unraveling the role of sirtuins in a variety of skin diseases, including melanoma and nonmelanoma skin cancers. In this review, we provide a discussion on the potential roles and implications of different sirtuins in skin-specific cellular processes, which may have relevance to skin health and skin diseases...
2017: Skin Pharmacology and Physiology
https://www.readbyqxmd.com/read/28697505/the-importance-of-11%C3%AE-oh-15-oxo-and-16-en-moieties-of-11%C3%AE-hydroxy-15-oxo-kaur-16-en-19-oic-acid-in-its-inhibitory-activity-on-melanogenesis
#8
Azusa Kuroi, Koji Sugimura, Ayako Kumagai, Arihiro Kohara, Yasuo Nagaoka, Hidehisa Kawahara, Minori Yamahara, Nobuo Kawahara, Hiroshi Takemori, Hiroyuki Fuchino
Cosmetic industries have an interest in exploring and developing materials that have the potential to regulate melanin synthesis in human skin. Although melanin protects the skin from ultraviolet irradiation, excess melanin can be undesirable, particularly on the face where spots or freckles are associated with an appearance of aging. In this study, we found that ent-11α-hydroxy-15-oxo-kaur-16-en-19-oic acid (11α-OH KA) in Pteris dispar Kunze strongly inhibited melanin synthesis by suppressing tyrosinase gene expression...
2017: Skin Pharmacology and Physiology
https://www.readbyqxmd.com/read/28689207/design-of-finasteride-loaded-nanoparticles-for-potential-treatment-of-alopecia
#9
Luís V Roque, Inês S Dias, Nuno Cruz, Ana Rebelo, Amílcar Roberto, Patrícia Rijo, Catarina P Reis
BACKGROUND/AIMS: Androgenetic alopecia is an extremely common dermatological disorder affecting both men and women. Oral finasteride (FNS), a synthetic 4-aza-3-oxosteroid compound with poor aqueous solubility, blocks the peripheral conversion of testosterone to dihydrotestosterone (DHT) in a significant reduction in DHT concentration, achieving satisfactory results in alopecia treatment. However, its oral intake generally causes severe side effects. Considering that there is currently no scientifically proven treatment, new drug delivery systems able to improve alopecia therapy are urgently required...
2017: Skin Pharmacology and Physiology
https://www.readbyqxmd.com/read/28662511/antimelanogenic-efficacy-of-melasolv-3-4-5-trimethoxycinnamate-thymol-ester-in-melanocytes-and-three-dimensional-human-skin-equivalent
#10
John Hwan Lee, Eun-Soo Lee, Il-Hong Bae, Jeong-Ah Hwang, Se-Hwa Kim, Dae-Yong Kim, Nok-Hyun Park, Ho Sik Rho, Yong Jin Kim, Seong-Geun Oh, Chang Seok Lee
BACKGROUND/AIMS: Excessive melanogenesis often causes unaesthetic hyperpigmentation. In a previous report, our group introduced a newly synthesized depigmentary agent, Melasolv™ (3,4,5-trimethoxycinnamate thymol ester). In this study, we demonstrated the significant whitening efficacy of Melasolv using various melanocytes and human skin equivalents as in vitro experimental systems. METHODS: The depigmentary effect of Melasolv was tested in melan-a cells (immortalized normal murine melanocytes), α-melanocyte-stimulating hormone (α-MSH)-stimulated B16 murine melanoma cells, primary normal human melanocytes (NHMs), and human skin equivalent (MelanoDerm)...
2017: Skin Pharmacology and Physiology
https://www.readbyqxmd.com/read/28651246/development-of-a-perfusion-platform-for-dynamic-cultivation-of-in-vitro-skin-models
#11
Kay Strüver, Wolfgang Friess, Sarah Hedtrich
Reconstructed skin models are suitable test systems for toxicity testing and for basic investigations on (patho-)physiological aspects of human skin. Reconstructed human skin, however, has clear limitations such as the lack of immune cells and a significantly weaker skin barrier function compared to native human skin. Potential reasons for the latter might be the lack of mechanical forces during skin model cultivation which is performed classically in static well-plate setups. Mechanical forces and shear stress have a major impact on tissue formation and, hence, tissue engineering...
2017: Skin Pharmacology and Physiology
https://www.readbyqxmd.com/read/28558374/development-of-an-in-vitro-test-procedure-to-determine-the-direct-infrared-a-protection-of-sunscreens-and-non-cosmetic-samples
#12
Jan Carlos Quistorf, Dieter Kockott, Birgit Garbe, Ulrike Heinrich, Hagen Tronnier, Nicole Braun
BACKGROUND: Every day human skin is exposed to infrared A (IRA) radiation as part of the natural sun rays. As IRA radiation accounts for around one third of the solar radiation, it has gained great attention concerning its effects on the human body and skin. In the past few years it has been discussed controversially whether IRA radiation (of solar origin) is harmful or not. Nonetheless, there are several sunscreens on the German market that claim IRA protection for themselves. AIMS: The present study seeks to find an experimental set-up and a test procedure for the determination and quantification of direct IRA protection (realized via reflection or absorption of the IRA radiation), since to our knowledge these do not yet exist...
2017: Skin Pharmacology and Physiology
https://www.readbyqxmd.com/read/28535540/development-of-a-synthetic-substrate-for-the-in-vitro-performance-testing-of-sunscreens
#13
Myriam Sohn, Camille Malburet, Laure Baptiste, Yvonne Prigl
PURPOSE: Polymethylmethacrylate (PMMA) plates generally used for the in vitro testing of sunscreens have failed to yield a satisfactory correlation between the sun protection factor (SPF) in vitro and that in vivo. In the present study, various polymers were investigated as alternative substrates to PMMA plates. PROCEDURES: In total, 14 polymers were tested in terms of ultraviolet (UV) transparency by transmission spectroscopy, and surface properties by contact angle measurement...
2017: Skin Pharmacology and Physiology
https://www.readbyqxmd.com/read/28528342/an-insight-into-the-changes-in-skin-texture-and-properties-following-dietary-intervention-with-a-nutricosmeceutical-containing-a-blend-of-collagen-bioactive-peptides-and-antioxidants
#14
Licia Genovese, Andrea Corbo, Sara Sibilla
BACKGROUND: Skin aging is a multifactorial phenomenon which causes alterations in skin physiological functions and, most visibly, phenotypic changes. In particular, during the aging process, hyaluronic acid, collagen, and elastin fibers undergo structural and functional changes. AIMS: This study aimed to give an insight into the photo-protective benefits and efficacy of an oral liquid nutricosmeceutical containing collagen bioactive peptides and antioxidants to counteract the signs of aging...
2017: Skin Pharmacology and Physiology
https://www.readbyqxmd.com/read/28423379/excessive-weight-favours-skin-physiology-up-to-a-point-another-expression-of-the-obesity-paradox
#15
Luís Monteiro Monteiro Rodrigues, Lídia Palma, Osvaldo Santos, Maria Angélica Almeida, Julia Bujan, Liliana Tavares
BACKGROUND/AIMS: Recently classified as an epidemic by the WHO, obesity (as well as the state of being overweight) clearly affects significant populations across all ages. The relationship between obesity and some diseases (e.g. cardiovascular ones) is known, although many paradoxes remain to be explained. Very little information is available, however, regarding its impact on skin physiology and skin disease. This study aims to examine the influence of excessive weight on epidermal hydration and transepidermal water loss, key variables of skin water balance and skin biomechanics...
2017: Skin Pharmacology and Physiology
https://www.readbyqxmd.com/read/28419984/topical-histamine-stimulates-repigmentation-of-nonsegmental-vitiligo-by-a-receptor-dependent-mechanism
#16
Jun Liu, Yan Xu, Tzu-Kai Lin, Chengzhi Lv, Peter M Elias, Mao-Qiang Man
BACKGROUND: Though vitiligo is a common depigmentary disorder, it still represents a substantial therapeutic challenge. Therapeutic options are limited in part due to its uncertain etiology. OBJECTIVE: Because recent studies suggest that histamine stimulates melanogenesis in vitro, we determined here whether topical histamine stimulates repigmentation in patients with stable, nonsegmental vitiligo. METHODS: A total of 23 otherwise normal volunteers with vitiligo, including 14 males and 9 females aged 6-59 years (mean age 29...
2017: Skin Pharmacology and Physiology
https://www.readbyqxmd.com/read/28407625/comparison-of-occlusive-and-open-application-in-a-psoriasis-plaque-test-design-exemplarily-using-investigations-of-mapracorat-0-1-ointment-versus-vehicle-and-reference-drugs
#17
Walter Wigger-Alberti, Ragna Williams, Yi-Ling von Mackensen, Maciej Hoffman-Wecker, Ulrike Grossmann, Gerald Staedtler, Richard Nkulikiyinka, Kaweh Shakery
BACKGROUND/AIMS: Psoriasis plaque tests (PPTs) are important tools in the early phases of antipsoriatic drug development. Two distinct PPT design variants (open vs. occluded drug application) are commonly used, but no previous work has aimed to directly compare and contrast their performance. METHODS: We compared the antipsoriatic efficacy of mapracorat 0.1% ointment and reference drugs reported in 2 separate studies, representing open and occluded PPT designs. The drug effect size was measured by sonography (mean change in echo-poor band thickness), chromametry, and standardized clinical assessment...
2017: Skin Pharmacology and Physiology
https://www.readbyqxmd.com/read/28407621/potential-applications-of-phyto-derived-ceramides-in-improving-epidermal-barrier-function
#18
Efrem N Tessema, Tsige Gebre-Mariam, Reinhard H H Neubert, Johannes Wohlrab
The outer most layer of the skin, the stratum corneum, consists of corneocytes which are coated by a cornified envelope and embedded in a lipid matrix of ordered lamellar structure. It is responsible for the skin barrier function. Ceramides (CERs) are the backbone of the intercellular lipid membranes. Skin diseases such as atopic dermatitis and psoriasis and aged skin are characterized by dysfunctional skin barrier and dryness which are associated with reduced levels of CERs. Previously, the effectiveness of supplementation of synthetic and animal-based CERs in replenishing the depleted natural skin CERs and restoring the skin barrier function have been investigated...
2017: Skin Pharmacology and Physiology
https://www.readbyqxmd.com/read/28376499/histoproteomic-characterization-of-localized-cutaneous-amyloidosis-in-x-linked-reticulate-pigmentary-disorder
#19
Vincenzo L'Imperio, Irene Bruno, Ingrid Rabach, Andrew Smith, Clizia Chinello, Martina Stella, Fulvio Magni, Fabio Pagni
No abstract text is available yet for this article.
2017: Skin Pharmacology and Physiology
https://www.readbyqxmd.com/read/28319939/radical-scavenging-activity-of-a-sunscreen-enriched-by-antioxidants-providing-protection-in-the-whole-solar-spectral-range
#20
Carla Souza, Patrícia Maia Campos, Sabine Schanzer, Stephanie Albrecht, Silke B Lohan, Jürgen Lademann, Maxim E Darvin, Martina C Meinke
BACKGROUND/AIM: The main reason for extrinsic skin aging is the negative action of free radicals. The formation of free radicals in the skin has been associated with ultraviolet (UV) exposure and also to visible (VIS) and near-infrared (NIR) irradiations. The aim of the present study was to evaluate the efficacy of a sunscreen in the whole solar range. METHODS: The radical-scavenging activity of a sunscreen in the UV, VIS, and NIR ranges was evaluated using electron paramagnetic resonance spectroscopy...
2017: Skin Pharmacology and Physiology
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