journal
https://read.qxmd.com/read/38408443/efficacy-of-topical-palmitoylethanolamide-levagen-for-the-management-of-eczema-symptoms-a-double-blind-comparator-controlled-randomized-clinical-trial
#1
JOURNAL ARTICLE
Amanda Rao, Amel A Moussa, Jane Erickson, David Briskey
INTRODUCTION: Eczema is a debilitating skin disorder clinically characterised by the development of itchy, dry, rough, and scaling skin caused by a series of rudimentary clinical phenotypes. METHODS: This double-blind, randomised, comparator-controlled trial evaluated the effectiveness of topical application of a novel palmitoylethanolamide formulation (Levagen+) compared with a standard moisturiser (comparator) to reduce eczema severity and improve patient outcomes...
February 26, 2024: Skin Pharmacology and Physiology
https://read.qxmd.com/read/38368874/development-of-a-semi-dry-method-for-measuring-drug-permeation-into-skin-using-an-electric-facial-care-device-and-iontophoresis
#2
JOURNAL ARTICLE
Yumi Touma, Mayumi Ichikawa, Masatake Kishi, Tomomi Yokota, Akio Fujisawa
INTRODUCTION: Percutaneous drug delivery systems are attractive not only as a therapeutic strategy but also for cosmetic treatment. Iontophoresis is a well-recognized method for promoting transdermal absorption of ionized compounds. Franz cells are generally used to estimate drug permeation of skin by iontophoresis. However, methods using Franz cells are less versatile; for instance, the method is unsuited for use with a portable electric facial care device having a working probe of a certain size and weight...
February 17, 2024: Skin Pharmacology and Physiology
https://read.qxmd.com/read/38325354/psychosocial-burden-in-people-with-atopic-dermatitis-effects-of-a-substance-free-basic-skin-care-in-a-randomized-health-care-study
#3
JOURNAL ARTICLE
Catharina Braren-von Stülpnagel, Matthias Augustin, Rachel Sommer, Lukas Westphal
BACKGROUND: Atopic dermatitis (AD) is a physical, emotional and social burden for patients. Most suffer from itching, pain and dry skin as well as sleep disturbances, experienced stigmatization, anxiety or depression. Therefore, it is important to consider the psychosocial well-being and also stigmatization in the treatment of people with AD. OBJECTIVE: The aim of this study was to compare clinical and psychosocial parameters between patients with different severity of AD and to analyse the effect of an Omega-6-fatty-acid-skin therapy...
February 7, 2024: Skin Pharmacology and Physiology
https://read.qxmd.com/read/38262395/effects-of-liquid-and-bar-soaps-on-the-skin-of-brazilian-newborns-a-randomized-controlled-trial
#4
JOURNAL ARTICLE
Mily Constanza Moreno Ramos, Maria Valeria Robles Velasco, Mariana Bueno, Maria de La Ó Ramalho Veríssimo
INTRODUCTION: Compared to adults, newborns' skin has thinner epidermis and stratum corneum with decreased hydration level, higher transepidermal water loss, and pH variation between 5.5 and 7.5. These characteristics can predispose the occurrence of dryness, infections, and dermatological conditions. Water and liquid soap with adequate formulation have shown to be beneficial and safe for newborns' skin. However, studies evaluating the effect of bar soap, products widely used in Brazil and Latin America, are unknown...
January 23, 2024: Skin Pharmacology and Physiology
https://read.qxmd.com/read/38176392/the-role-of-intra-follicular-shear-forces-in-hidradenitis-suppurativa
#5
LETTER
Bor Hrvatin Stancic, Jurr Boer, Mateja Dolenc-Voljč, Gregor B E Jemec
No abstract text is available yet for this article.
January 4, 2024: Skin Pharmacology and Physiology
https://read.qxmd.com/read/38104550/turpentine-ointment-for-the-treatment-of-folliculitis-an-open-prospective-randomized-placebo-and-comparator-controlled-multicenter-trial
#6
JOURNAL ARTICLE
Rainer C Görne, Nils Günnewich, Hilde Huber, Britta Wallmen, Christian Zimmermann
INTRODUCTION: Folliculitis is a painful infection and inflammation of hair follicles, mostly caused by bacterial, fungal or, more rarely, viral infections. Turpentine derivatives have been used traditionally to treat various skin infections and could thus also be effective in treating folliculitis. We carried out an open, prospective, randomized, placebo- and comparator-controlled multicenter trial to evaluate the efficacy and safety of an ointment containing pine turpentine oil, larch turpentine, and eucalyptus oil in the treatment of acute folliculitis...
December 15, 2023: Skin Pharmacology and Physiology
https://read.qxmd.com/read/38035548/linoleate-containing-acylglucosylceramide-acylceramide-and-events-associated-with-formation-of-the-epidermal-permeability-barrier
#7
REVIEW
Philip W Wertz
BACKGROUND: Linoleate-containing acylglucosylceramide (GLC-CER[EOx], where x = sphingosine (S), dihydrosphingosine (dS), phytosphingosine (P) or 6-hydroxysphingosine (H)) in the viable epidermis serve as the precursors to the linoleate-containing acylceramides (CER[EOx]) in the stratum corneum (SC) and the cornified lipid envelope (CLE), both of which are essential for the barrier function of the skin. SUMMARY: CLE formation and envelope maturation takes place across the SC...
November 30, 2023: Skin Pharmacology and Physiology
https://read.qxmd.com/read/38008088/curcumin-as-a-topical-agent-in-clinical-studies
#8
REVIEW
Ritamaria Di Lorenzo, Federica Forgione, Antonietta Bernardi, Antonia Sacchi, Sonia Laneri, Giovanni Greco
BACKGROUND: Curcumin is a polyphenolic compound present in turmeric (Curcuma longa). Curcumin, turmeric powder, and extracts are widely used in traditional Indian medicine and are active ingredients of dietary supplements and cosmeceutical products. The pharmacological properties of curcumin/turmeric as well as the studies performed in vitro, in animal models and in volunteers to assess its effectiveness have been the objects of a vast literature. Most of the clinical studies report on the effects of curcumin/turmeric administered orally while only a few describe its topical applications...
November 26, 2023: Skin Pharmacology and Physiology
https://read.qxmd.com/read/37788642/dill-extract-preserves-dermal-elastic-fibers-network-and-functionality-implication-of-elafin
#9
JOURNAL ARTICLE
Géraldine Aimond, Stéphane Nicolle, Romain Debret, Valérie Oréa, Audrey Josset-Lamaugarny, Jean-François Palierne, Pascal Sommer, Dominique Sigaudo-Roussel, Bérengère Fromy
INTRODUCTION: Elastic skin fibers lose their mechanical properties during aging due to enzymatic degradation, lack of maturation or post-translational modifications. Dill extract has been observed to increase elastin protein expression and maturation in a 3D skin model, to improve mechanical properties of skin, to increase elastin protein expression in vascular smooth muscle cells, to preserve aortic elastic lamella and to prevent glycation. OBJECTIVE: The aim of the study was to highlight dill actions on elastin fibers during ageing thanks to elastase digestion model and the underlying mechanism...
October 3, 2023: Skin Pharmacology and Physiology
https://read.qxmd.com/read/37717566/human-epidermal-keratinocytes-in-culture-a-story-of-multiple-recipes-for-a-single-cell-type
#10
REVIEW
Yves Poumay, Emilie Faway
BACKGROUND: For one half-century, cultures of human epidermal keratinocytes have opened new paths of research in skin biology and dermatology. Either performed with serum and feeder-layer, in serum-free conditions, or in autocrine conditions, cells cultured as monolayers became research materials for basic science and dermatology, as well as a source for grafting, particularly to treat severely burned patients. More recently tissue reconstruction at air-liquid interface has opened new perspectives for in vitro toxicology, studies of epidermal barrier, and modeling skin diseases...
September 16, 2023: Skin Pharmacology and Physiology
https://read.qxmd.com/read/37717558/the-skin-barrier-and-moisturization-function-disruption-and-mechanisms-of-repair
#11
REVIEW
Jeffrey Rajkumar, Neha Chandan, Peter Lio, Vivian Shi
BACKGROUND: The anatomic layers of the skin are well-described; recent research into the barrier capabilities of the skin has led to the development of a functional model of the skin barrier. Moisturization has been consistently recommended for use in conditions such as atopic dermatitis, in which barrier disruption plays a key role in disease. This review aims to analyze the skin barrier in the context of this function model, with a focus on the mechanisms by which moisturizers support each of the functional layers of the skin barrier to promote homeostasis and repair...
September 15, 2023: Skin Pharmacology and Physiology
https://read.qxmd.com/read/37903478/erratum
#12
(no author information available yet)
No abstract text is available yet for this article.
August 31, 2023: Skin Pharmacology and Physiology
https://read.qxmd.com/read/37640014/association-of-epidermal-biophysical-properties-with-obesity-and-its-implications
#13
REVIEW
Tingting Zhu, Shuyun Yang, Theodora M Mauro, Mao-Qiang Man
Background Obesity is a condition defined by an excess amount of body fat, with body mass index of 30 and higher. It is associated with a number of other medical conditions, including insulin resistance, diabetes mellitus, and cardiovascular diseases, as well as dyslipidemia, and it is also associated with several cutaneous disorders such as atopic dermatitis, psoriasis, intertriginous dermatitis, acanthosis nigricans, and skin infections. Summary Evidence suggests a link between obesity and epidermal dysfunction...
August 28, 2023: Skin Pharmacology and Physiology
https://read.qxmd.com/read/37490882/a-prospective-randomized-controlled-pilot-study-to-assess-the-response-and-tolerability-of-cold-atmospheric-plasma-for-rosacea
#14
JOURNAL ARTICLE
Stella Hofmeyer, Frank Weber, Sandra Gerds, Steffen Emmert, Alexander Thiem
INTRODUCTION: Rosacea is a common, facial, chronic inflammatory skin disease. Due to its complex pathogenesis, adequate therapy of rosacea can be challenging. An innovative recent therapeutic tool is cold atmospheric plasma (CAP), which is already established in the treatment of chronic wounds and promising in different other skin diseases. METHODS: In a split-face pilot study we investigated dielectric-barrier-discharged CAP in erythemato-telangiectatic (ETR) and/or papulopustular rosacea (PPR)...
July 25, 2023: Skin Pharmacology and Physiology
https://read.qxmd.com/read/36966539/the-effects-of-mucopolysaccharide-polysulfate-on-steroid-induced-tight-junction-barrier-dysfunction-in-human-epidermal-keratinocytes-and-a-3d-skin-model
#15
JOURNAL ARTICLE
AKira Koda, Yuko Ishii, Ayu Kashiwagi, Mika Fujikawa, Keisuke Kikuchi, Ryota Hashimoto, Yuhki Ueda, Takaaki Doi
INTRODUCTION: The long-term use of topical corticosteroids (TCS) is associated with side effects such as skin atrophy and barrier deterioration. Moisturizers, such as mucopolysaccharide polysulfate (MPS), have been reported to prevent relapses in atopic dermatitis (AD) when used in combination with TCS. However, the mechanisms underlying the positive effects of MPS in combination with TCS in AD are poorly understood. In the present study, we investigated the effects of MPS in combination with clobetasol 17-propionate (CP) on tight junction (TJ) barrier function in human epidermal keratinocytes (HEKa) and 3D skin models...
March 25, 2023: Skin Pharmacology and Physiology
https://read.qxmd.com/read/36927995/skin-physiology-mucosal-functions-and-symptoms-are-modulated-by-grass-pollen-and-ozone-double-exposure-in-allergic-patients
#16
JOURNAL ARTICLE
Joachim Fluhr, Katarina Stevanovic, Priyanka Joshi, Karl-Christian Bergmann, Leonie S Herzog, Yasmeen Alwaheed, Shirina Al Sowaidi, Torsten Zuberbier
INTRODUCTION: Along with climate changes, we see an increase in allergic symptoms and the number of pollen-allergic patients in many countries. Increased allergic symptoms are associated with an elevated ozone exposure which may be linked by impaired epithelial barrier function. This study aimed to quantify the clinical effect of ozone and pollen double exposure (DE). We tested whether ozone impairs barrier-related skin physiology and mucosal functions under double exposure with pollen ozone in grass pollen-allergic patients versus healthy controls...
March 16, 2023: Skin Pharmacology and Physiology
https://read.qxmd.com/read/36927667/the-epidermal-environment-s-influence-on-the-dermal-environment-in-response-to-external-stress
#17
JOURNAL ARTICLE
Masaki Yoshida, Kyong-Oh Shin, Sora Muraoka, Yerim Choi, Jae-Ho Park, Soo-Hyun Park, Jin-Taek Hwang, Kyungho Park, Yoshikazu Uchida
INTRODUCTION: The outermost layer of the skin, the epidermis, is directly exposed to external stress (e.g., irradiation, allergens and chemicals). Changes in epidermal conditions/environment in response to this stress could also influence conditions of the dermis, located directly beneath the epidermis. Yet, whether/how any epidermal environment changes in response to external stress affect dermal functions has not been completely clarified. METHODS: We employed ultraviolet irradiation B (UVB) (which does not reach the dermis) as a model of external stress...
March 16, 2023: Skin Pharmacology and Physiology
https://read.qxmd.com/read/36917958/alterations-in-epidermal-biophysical-properties-in-autistic-children
#18
Bin Wang, You-Dong Li, Zi-Yan Wang, Jia-Qing Zhao, Guo-Qiang Zhang, Mao-Qiang Man
Autism is a neurodevelopmental disorder. Individuals with autism can exhibit multiple neurological symptoms such as deficit in social communication, restricted interests and repetitive behaviors. Recent study showed that murine model of autism displays an increased transepidermal water loss (TEWL) and dry skin. But whether epidermal functions are also altered in children with autism is unknown. In the present study, TEWL, stratum corneum hydration and skin surface pH were compared between children with autism (N=56) and normal controls (N=48)...
March 14, 2023: Skin Pharmacology and Physiology
https://read.qxmd.com/read/36863326/development-of-an-in-vitro-functional-assay-to-evaluate-the-occlusive-properties-of-moisturizers-on-dry-skin
#19
JOURNAL ARTICLE
Soonjin Hong, Prithwiraj Maitra, Audrey Nguyen, Kuniko Kadoya, Rahul C Mehta, Elizabeth SelwanLewis
INTRODUCTION: Dry skin is a hallmark of impaired skin barrier function. Moisturizers are a mainstay of treatment to help the skin retain moisture, and there is a high consumer demand for effective products. However, the development and optimization of new formulations are hampered due to a lack of reliable efficacy measures using in vitro models. METHODS: In this study, a microscopy-based barrier functional assay was developed using an in vitro skin model of chemically induced barrier damage to evaluate the occlusive activity of moisturizers...
March 2, 2023: Skin Pharmacology and Physiology
https://read.qxmd.com/read/36754026/evaluation-of-a-novel-skin-emollient-cream-on-skin-lipidome-and-lipids-organization
#20
JOURNAL ARTICLE
Carine Jacques, Caroline Dejean, Christian Klose, Emilie Leccia, Sandrine Bessou-Touya, Alain Delarue, Hélène Duplan
INTRODUCTION: The stratum corneum (SC) matrix is composed of free fatty acids, cholesterol and ceramides (CERs), which play a key role in the skin barrier function. Changes in the composition and content of skin lipids will affect the function of the skin barrier. The effect of a glycerol/petrolatum-based emollient (G/P-emollient) cream on the lipid profiles of isolated ex vivo human SC and the SC of a reconstructed human epithelial (RHE) model were measured. METHODS: The spatial organization of the cream and the isolated SC intercellular matrix was studied using X-ray diffraction...
February 8, 2023: Skin Pharmacology and Physiology
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