journal
MENU ▼
Read by QxMD icon Read
search

Skin Pharmacology and Physiology

journal
https://www.readbyqxmd.com/read/29742517/solvent-extracted-wool-wax-thermotropic-properties-and-skin-efficacy
#1
Clara Barba Albanell, Victor Carrer, Meritxell Marti, Jordi Iglesias, Joan Iglesias, Luisa Coderch
BACKGROUND/AIMS: Wool wax is a soft, yellow, waxy substance that is secreted by the sebaceous glands of sheep. The purpose of wool wax is to waterproof and protect the wool. Chemically, wool wax is a complex mixture of esters, fatty acids, and alcohols. Wool waxes with different prop-erties can be obtained by following different extraction methodologies. METHODS: Two differently extracted wool waxes are compared in this study. Their effectiveness in mimicking the properties of skin lipids is evaluated...
May 9, 2018: Skin Pharmacology and Physiology
https://www.readbyqxmd.com/read/29698950/the-influence-of-reactive-oxygen-species-and-glucocorticoids-on-dry-skin-in-a-mouse-model-of-arthritis
#2
Kenji Goto, Keiichi Hiramoto, Mayu Kawakita, Miyu Yamaoka, Kazuya Ooi
BACKGROUND: Dry skin induced by rheumatoid arthritis (RA) causes itching, which negatively influences a patient's quality of life. We previously reported that mast cells are related to dry skin in arthritic mice. However, the mechanism of mast cell activation is unclear. In this study, we examined the mechanism underlying the formation of dry skin induced by mast cells in arthritis that involves thymic stromal lymphopoietin (TSLP), neutrophils, reactive oxygen species (ROS), and glucocorticoids...
April 26, 2018: Skin Pharmacology and Physiology
https://www.readbyqxmd.com/read/29649806/rituximab-in-refractory-chronic-spontaneous-urticaria-an-encouraging-therapeutic-approach
#3
Andrea Combalia, Ricardo A Losno, Sergio Prieto-González, J Manuel Mascaró
BACKGROUND: Chronic spontaneous urticaria (CSU) is a frequent mast cell-driven disease that affects approximately 0.5-1% of the population. Antihistamines are currently the drugs of choice in patients with CSU. Omalizumab has been shown to be very effective in CSU and has been recently approved as second-line therapy. However, although its introduction has markedly improved the therapeutic possibilities for CSU, there is still a hard core of patients who do not respond and require effective treatment...
April 12, 2018: Skin Pharmacology and Physiology
https://www.readbyqxmd.com/read/29621751/skin-barrier-restoration-and-moisturization-using-horse-oil-loaded-dissolving-microneedle-patches
#4
Chisong Lee, Younghyon Andrew Eom, Huisuk Yang, Mingyu Jang, Sang Uk Jung, Ye Oak Park, Si Eun Lee, Hyungil Jung
BACKGROUND: Horse oil (HO) has skin barrier restoration and skin-moisturizing effects. Although cream formulations have been used widely and safely, their limited penetration through the stratum corneum is a major obstacle to maximizing the cosmetic efficacy of HO. Therefore, we aimed to encapsulate HO in a cosmetic dissolving microneedle (DMN) for efficient transdermal delivery. METHODS: To overcome these limitations of skin permeation, HO-loaded DMN (HO-DMN) patches were developed and evaluated for their efficacy and safety using in vitro and clinical studies...
April 5, 2018: Skin Pharmacology and Physiology
https://www.readbyqxmd.com/read/29617695/topical-treatment-of-skin-injury-inflicted-in-mice-by-x-ray-irradiation
#5
Evangelia Meimeti, Antonios Kafanas, Panagoula Pavlou, Antonia Evangelatou, Panagiota Tsouparelou, Stelios Kanellopoulos, Panagiotis Kipouros, Nikolaos Koliarakis, Georgios Leonis, Efstathia Ioannou, Vassilios Roussis, Michail Rallis
BACKGROUND/AIMS: There is no treatment, without side effects, efficiently preventing or curing skin burns, caused by radiotherapy. A new experimental topical treatment protocol was assessed in mice receiving orthovoltage X-rays at an equivalent dose to that applied to human breast cancer patients in conventional radiotherapy. METHODS: SKH-HR2 female hairless mice were irradiated on their dorsum with a total dose of 4,300 cGy during a 1-month period (20 fractions)...
April 4, 2018: Skin Pharmacology and Physiology
https://www.readbyqxmd.com/read/29614497/effect-of-fluid-intake-on-hydration-status-and-skin-barrier-characteristics-in-geriatric-patients-an-explorative-study
#6
Merve Akdeniz, Heiner Boeing, Ursula Müller-Werdan, Volkan Aykac, Annika Steffen, Mareike Schell, Ulrike Blume-Peytavi, Jan Kottner
BACKGROUND/AIM: Inadequate fluid intake is assumed to be a trigger of water-loss dehydration, which is a major health risk in aged and geriatric populations. Thus, there is a need to search for easy to use diagnostic tests to identify dehydration. Our overall aim was to investigate whether skin barrier parameters could be used for predicting fluid intake and/or hydration status in geriatric patients. METHODS: An explorative observational comparative study was conducted in a geriatric hospital including patients aged 65 years and older...
April 3, 2018: Skin Pharmacology and Physiology
https://www.readbyqxmd.com/read/29614495/commentary-on-the-evidence-and-consensus-based-s3-guidelines-for-the-treatment-of-actinic-keratosis-published-by-the-international-league-of-dermatological-societies-in-cooperation-with-the-european-dermatology-forum
#7
Thomas L Diepgen, Joachim Kresken, Jean Krutmann, Hans F Merk, Erik Senger, Christian Surber, Rolf-Markus Szeimies
In 2015, the International League of Dermatological Societies and the European Dermatology Forum published a guideline for the treatment of actinic keratosis, which is classified as an evidence- and consensus-based S3 guideline. From the point of view of the GD Task Force "Licht.Hautkrebs.Prävention," an interdisciplinary expert panel of the Society for Dermopharmacy for the prevention and treatment of skin cancer, this guideline reveals strengths and weaknesses but, in summary, does not meet the claim for an evidence- and consensus-based S3 guideline...
April 3, 2018: Skin Pharmacology and Physiology
https://www.readbyqxmd.com/read/29597196/dermocosmetics-for-use-in-rosacea-guideline-of-the-society-for-dermopharmacy
#8
Joachim Kresken, Ursula Kindl, Walter Wigger-Alberti, Benjamin M Clanner-Engelshofen, Markus Reinholz
Rosacea is a widespread inflammatory skin disease that is chronically recurrent and affects predominately the central parts of the face. Affected individuals typically react to numerous cosmetics with redness, burning, and/or worsening of the complexion. Consequently, there is a high demand for dermocosmetics that do not provoke such reactions and are suitable for use in rosacea. The present guideline of the Society for Dermopharmacy describes the requirements that dermocosmetics for use in rosacea should meet...
March 29, 2018: Skin Pharmacology and Physiology
https://www.readbyqxmd.com/read/29566388/punicalagin-and-epigallocatechin-3-gallate-rescue-cell-viability-and-attenuate-inflammatory-responses-of-human-epidermal-keratinocytes-exposed-to-airborne-particulate-matter-pm10
#9
Jin Kyung Seok, Jeong-Won Lee, Young Mi Kim, Yong Chool Boo
BACKGROUND/AIMS: Airborne particulate matter with a diameter of < 10 µm (PM10) causes oxidative damage, inflammation, and premature skin aging. In this study, we evaluated whether polyphenolic antioxidants attenuate the inflammatory responses of PM10-exposed keratinocytes. METHODS: Primary human epidermal keratinocytes were exposed in vitro to PM10 in the absence or presence of punicalagin and (-)-epigallocatechin-3-gallate (EGCG), which are the major polyphenolic antioxidants found in pomegranate and green tea, respectively...
March 22, 2018: Skin Pharmacology and Physiology
https://www.readbyqxmd.com/read/29539605/effects-of-short-term-moisturizer-application-in-different-ethnic-skin-types-noninvasive-assessment-with-optical-coherence-tomography-and-reflectance-confocal-microscopy
#10
Işın Sinem Bağcı, Cristel Ruini, Anne-Charlotte Niesert, Orsolya N Horváth, Carola Berking, Thomas Ruzicka, Tanja von Braunmühl
BACKGROUND/AIMS: Ethnic skin types are known to differ in their morphological and physiological features. Thus, treatment responses may vary among different races. We aimed to assess skin morphology of different ethnicities and to compare the effect of short-term moisturizer application using optical coherence tomography (OCT) and reflectance confocal microscopy (RCM). METHODS: Thirty healthy female subjects of European, Asian and Black ethnicity at 30-45 years of age were included in the study...
March 14, 2018: Skin Pharmacology and Physiology
https://www.readbyqxmd.com/read/29510378/physiological-and-molecular-effects-of-in-vivo-and-ex-vivo-mild-skin-barrier-disruption
#11
Eva K B Pfannes, Lina Weiss, Sabrina Hadam, Jessica Gonnet, Béhazine Combardière, Ulrike Blume-Peytavi, Annika Vogt
The success of topically applied treatments on skin relies on the efficacy of skin penetration. In order to increase particle or product penetration, mild skin barrier disruption methods can be used. We previously described cyanoacrylate skin surface stripping as an efficient method to open hair follicles, enhance particle penetration, and activate Langerhans cells. We conducted ex vivo and in vivo measurements on human skin to characterize the biological effect and quantify barrier disruption-related inflammation on a molecular level...
March 7, 2018: Skin Pharmacology and Physiology
https://www.readbyqxmd.com/read/29428960/sesquiterpene-enriched-extract-of-curcuma-aeruginosa-roxb-retards-axillary-hair-growth-a-randomised-placebo-controlled-double-blind-study
#12
Jukkarin Srivilai, Kanjana Nontakhot, Thanawan Nutuan, Neti Waranuch, Nantaka Khorana, Wudtichai Wisuthiprot, C Norman Scholfield, Katechan Champachaisri, Kornkanok Ingkaninan
BACKGROUND: Sesquiterpenes in Curcuma aeruginosa Roxb. inhibit steroid 5α-reductase and dihydrotestosterone production, and reverse androgenic alopecia. This study sought to show that a high sesquiterpene C. aeruginosa extract (CA-ext) retards axillary hair growth in women. METHODS: Thirty women (age 20-52 years) were recruited into a 12-week, double-blind, placebo-controlled intervention for CA-ext treatment, where they were randomly allocated to a left or right armpit group...
2018: Skin Pharmacology and Physiology
https://www.readbyqxmd.com/read/29408821/a-time-series-study-of-the-effect-of-air-pollution-on-outpatient-visits-for-acne-vulgaris-in-beijing
#13
Wei Liu, Xiaochuan Pan, Andrea Vierkötter, Qun Guo, Xuying Wang, Qiaowei Wang, Sophie Seité, Dominique Moyal, Tamara Schikowski, Jean Krutmann
BACKGROUND/AIMS: There is increasing evidence that exposure to air pollutants, including particulate matter (PM2.5, PM10), nitrogen dioxide (NO2), and sulfur dioxide (SO2), might aggravate preexisting skin diseases such as eczema and urticaria. Here we investigated if a possible link exists between air pollution and acne vulgaris. We assessed the association between ambient air pollutant concentrations and the number of visits of patients for acne vulgaris to a dermatological outpatient clinic in Beijing, China, from April 1, 2012 to April 30, 2014...
2018: Skin Pharmacology and Physiology
https://www.readbyqxmd.com/read/29393263/new-hydrogels-enriched-with-antioxidants-from-saffron-crocus-can-find-applications-in-wound-treatment-and-or-beautification
#14
Keti Zeka, Ketan C Ruparelia, Claudia Sansone, Guido Macchiarelli, Maria Adelaide Continenza, Randolph R J Arroo
Saffron extracts have a long history of application as skin protectant, possibly due to their ability to scavenge free radicals. In this work, the performance of a hydrogel enriched with antioxidant compounds isolated from saffron crocus (Crocus sativus L.) petals was tested. These hydrogels could be considered as new drug delivery system. Hydrogels are crosslinked polymer networks that absorb large quantities of water but retain the properties of a solid, thus making ideal dressings for sensitive skin. We tested antioxidant-enriched hydrogels on primary mouse fibroblasts...
2018: Skin Pharmacology and Physiology
https://www.readbyqxmd.com/read/29353285/laser-scanning-microscopic-investigations-of-the-decontamination-of-soot-nanoparticles-from-the-skin
#15
Jürgen Lademann, Fanny Knorr, Alexa Patzelt, Martina C Meinke, Heike Richter, Jean Krutmann, Eckart Rühl, Olivier Doucet
BACKGROUND/AIMS: Airborne pollutants, such as nano-sized soot particles, are increasingly being released into the environment as a result of growing population densities and industrialization. They can absorb organic and metal compounds with potential biological activity, such as polycyclic aromatic hydrocarbons and airborne pollen allergens. Local and systemic toxicities may be induced in the skin if the particulates release their harmful components upon dermal contact. METHODS: In the present study, skin pretreatments with serum and/or shield as barrier formulations prior to exposure and washing with a cleanser subsequent to exposure were evaluated as a protection and decontamination strategy using laser scanning microscopy...
2018: Skin Pharmacology and Physiology
https://www.readbyqxmd.com/read/29306952/vitamin-d-and-the-pathophysiology-of-inflammatory-skin-diseases
#16
Meenakshi Umar, Konduru S Sastry, Fatima Al Ali, Moza Al-Khulaifi, Ena Wang, Aouatef I Chouchane
BACKGROUND: Vitamin D is a secosteroid, which was initially known for its skeletal role; however, in recent years, its functions in different organs have been increasingly recognized. In this review, we will provide an overview of vitamin D functions in the skin physiology with specific focus on its role in certain inflammatory skin conditions such as psoriasis and atopic dermatitis. METHODS: A comprehensive literature search was carried out in PubMed and Google Scholar databases using keywords like "vitamin D," "skin," "atopic dermatitis," and "psoriasis...
2018: Skin Pharmacology and Physiology
https://www.readbyqxmd.com/read/29262420/neoplastic-multifocal-skin-lesions-biology-etiology-and-targeted-therapies-for-nonmelanoma-skin-cancers
#17
Ana R Fernandes, Ana C Santos, Elena Sanchez-Lopez, Andjekla B Kovačević, Marta Espina, Ana C Calpena, Francisco J Veiga, Maria L Garcia, Eliana B Souto
Neoplastic skin lesions are multifocal, diffuse skin infiltrations of particular relevance in the differential diagnosis of ulcerative, nodular, or crusting skin lesions. Nonmelanoma skin cancers (NMSCs), namely, basal cell carcinoma (BCC), squamous cell carcinoma (SCC), and also actinic keratosis (AK), are the most common malignant tumors in humans. BCCs do not proliferate rapidly and most of the times do not metastasize, while SCCs are more infiltrative, metastatic, and destructive. AKs are precursor lesions of cutaneous SCCs...
2018: Skin Pharmacology and Physiology
https://www.readbyqxmd.com/read/29262416/consensus-on-wound-antisepsis-update-2018
#18
Axel Kramer, Joachim Dissemond, Simon Kim, Christian Willy, Dieter Mayer, Roald Papke, Felix Tuchmann, Ojan Assadian
Wound antisepsis has undergone a renaissance due to the introduction of highly effective wound-compatible antimicrobial agents and the spread of multidrug-resistant organisms (MDROs). However, a strict indication must be set for the application of these agents. An infected or critically colonized wound must be treated antiseptically. In addition, systemic antibiotic therapy is required in case the infection spreads. If applied preventively, the Wounds-at-Risk Score allows an assessment of the risk for infection and thus appropriateness of the indication...
2018: Skin Pharmacology and Physiology
https://www.readbyqxmd.com/read/29131139/capsaicin-used-on-skin-influences-ion-transport-pathways-an-in-vitro-study
#19
Iga Hołyńska-Iwan, Inga Dziembowska, Paulina Smyk, Magdalena Lampka, Dorota Olszewska-Słonina
Acute, adverse skin effects to capsaicin can be activated by inhibition of sodium transport not only in nociceptive neurons, but also in keratinocytes. The aim of the current study was to describe and compare immediate (15 s) and prolonged (30 min) effects of capsaicin on epidermal (not neural) sodium transport using a rabbit skin model. Skin fragments (n = 169) were incubated in 4 conditions: undisturbed ion transport (U; n = 48); inhibited sodium transport (INa; n = 34) with amiloride used as sodium transport blocker; long-term irritation by capsaicin with undisturbed ion transport (CAPSA-U; n = 43) and with inhibited sodium transport (CAPSA-INa; n = 35)...
2018: Skin Pharmacology and Physiology
https://www.readbyqxmd.com/read/29131127/pleiotropic-effects-of-white-willow-bark-and-1-2-decanediol-on-human-adult-keratinocytes
#20
Eleonora Bassino, Franco Gasparri, Luca Munaron
BACKGROUND: Acne vulgaris is a common skin defect, usually occurring during adolescence, but often it can persist in adults leaving permanent face scarring. Acne is usually treated with topical drugs, oral antibiotics, retinoids, and hormonal therapies, but medicinal plants are increasingly employed. OBJECTIVE: To investigate the protective role of white willow bark (WWB) and 1,2-decanediol (DD) on the damage caused by lipopolysaccharides (LPS) on human adult keratinocytes (HaCaT)...
2018: Skin Pharmacology and Physiology
journal
journal
40517
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"