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Skin Pharmacology and Physiology

Konstantina Grammenandi, Maria Kyriazi, Alexandra Katsarou-Katsari, Othon Papadopoulos, Ioanna Anastassopoulou, Georgios T Papaioannou, Alexandros Sagriotis, Michail Rallis, Howard I Maibach
Low-molecular-weight antioxidants are some of the most efficient agents of the skin defense mechanism against environmental factors, such as cosmic rays, smoke, and pollutants. The total skin concentrations of hydrophilic ascorbic and uric acids, as well as lipophilic α-tocopherol, β-carotene, and ubiquinol-10 antioxidants were determined by an HPLC-EC detector from 18 biopsies of human nonmelanoma skin carcinomas and 18 biopsies from skin areas adjacent to carcinomas. No significant differences in the concentrations of lipophilic antioxidants in both carcinomas and normal-looking skin areas adjacent to carcinomas were observed...
January 19, 2017: Skin Pharmacology and Physiology
Cornelia Wiegand, Kirsten Reddersen, Uta-Christina Hipler, Martin Abel, Peter Ruth, Anneke Andriessen
BACKGROUND: Removal of nonvital tissue is an accepted method to eradicate biofilms and to stimulate wound healing. Debridement using a monofilament polyester fiber pad has clinically been shown to be effective as well as pain and trauma free. METHODS: For in vitro determination of the cleansing capacity of this product compared to gauze swabs, a wound debridement model was used with glass plates coated with a bovine serum albumin solution, stained with hematoxylin...
January 18, 2017: Skin Pharmacology and Physiology
Miyuki Tanaka, Yuki Yamamoto, Eriko Misawa, Kazumi Nabeshima, Marie Saito, Koji Yamauchi, Fumiaki Abe, Fukumi Furukawa
BACKGROUND/AIMS: Our previous study confirmed that Aloe sterol stimulates collagen and hyaluronic acid production in human dermal fibroblasts. This study aims to investigate whether Aloe sterol intake affects skin conditions. METHODS: We performed a 12-week, randomized, double-blind, placebo-controlled study to evaluate the effects of oral Aloe sterol supplementation on skin elasticity, hydration, and the collagen score in 64 healthy women (age range 30-59 years; average 44...
January 14, 2017: Skin Pharmacology and Physiology
Bart Desmedt, Gamze Ates, Patricia Courselle, Jacques O De Beer, Vera Rogiers, Benoit Hendrickx, Eric Deconinck, Kristien De Paepe
In Europe, hydroquinone is a forbidden cosmetic ingredient. It is, however, still abundantly used because of its effective skin-whitening properties. The question arises as to whether the quantities of hydroquinone used become systemically available and may cause damage to human health. Dermal absorption studies can provide this information. In the EU, dermal absorption has to be assessed in vitro since the Cosmetic Regulation 1223/2009/EC forbids the use of animals. To obtain human-relevant data, a Franz diffusion cell protocol was validated using human skin...
January 5, 2017: Skin Pharmacology and Physiology
Verena Korn, Christian Surber, Georgios Imanidis
BACKGROUND/AIMS: To determine the roughness of the surface of human skin at highly sun-exposed anatomical sites in a wide age range in order to derive consequences for sunscreen application. METHODS: The forehead, cheek, nose, shoulder, and dorsal hand of 4 age groups (0-9, 20-39, 40-59, and >60 years) were investigated by replica formation, and areal topography was determined by confocal chromatic imaging. The arithmetic mean height as a roughness parameter and the void volume of the surface profile were calculated...
January 5, 2017: Skin Pharmacology and Physiology
Anne-Dorothee Steinkamp, Laurenz Schmitt, Xiaoyun Chen, Katharina Fietkau, Ruth Heise, Jens M Baron, Carsten Bolm
Tasisulam is a promising antitumor agent with complex pharmacology, which is used as an antiproliferative agent in patients with metastatic melanoma and other solid tumors. Phase 2 melanoma studies showed promising results but had to be stopped because of insufficient tasisulam clearance leading to toxic side effects. To reduce the negative effects of tasisulam, we synthesized a novel sulfonimidamide-based analog to evaluate its antiproliferative effects in comparison to the original compound by performing a cell proliferation assay in melanoma cell lines SKMel23 and A375...
December 24, 2016: Skin Pharmacology and Physiology
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No abstract text is available yet for this article.
2016: Skin Pharmacology and Physiology
Johannes Wohlrab, Reinhard H H Neubert, Elfi Sommer, Julia Michael
Mometasone furoate (MMF) is a modern glucocorticoid of the 4th generation, which has been proven not only for inhalation but also for cutaneous treatment. Due to its lipophilic character, it is mainly used in ointments and creams with an outer lipophilic phase (W/O type). However, this study investigated the cutaneous cytotoxicology of MMF and tried to characterize its pharmacokinetic effects on the skin using an O/W preparation. An HPLC method has been developed and validated for the detection of MMF in cutaneous tissue, and concentration-time curves of MMF were created after cutaneous application on unaffected as well as lesional skin...
2016: Skin Pharmacology and Physiology
Dorothee Daehnhardt, Stephan Daehnhardt-Pfeiffer, Judith Schulte-Walter, Thomas Neubourg, Eckhard Hanisch, Christel Schmetz, Marion Breuer, Regina Fölster-Holst
BACKGROUND/AIMS: Dry skin, or xerosis, is a common condition and a key feature of skin diseases like atopic dermatitis (AD) and ichthyosis vulgaris. Foot xerosis may exist without underlying disease and could be related to very mild forms of AD or ichthyosis vulgaris. The synthesis of important skin lipids (cholesterol, free fatty acids and ceramides) is reduced in xerosis and AD, and reduced lipid synthesis is responsible for a lack of lipids and enzymes in the skin barrier. This slows down reorganisation of the lipid lamellae in the stratum corneum (SC)...
2016: Skin Pharmacology and Physiology
Cornelia Wiegand, Sarah Fink, Oliver Beier, Kerstin Horn, Andreas Pfuch, Arnd Schimanski, Bernd Grünler, Uta-Christina Hipler, Peter Elsner
BACKGROUND: Application of cold atmospheric pressure plasmas (CAPs) in or on the human body was termed 'plasma medicine'. So far, plasmas were utilized for sterilization of implants, other heat-sensitive products, or employed for chemical surface modifications. By now, CAPs are further used effectively for wound treatment. The present study analyses the effect of a plasma jet with air or nitrogen as process gas, previously evaluated for antimicrobial efficacy, on human cells using a 3D skin model...
2016: Skin Pharmacology and Physiology
Wenna Zhou, Heng Xu, Guangxiang Luan, HongLun Wang, Xiaoyan Wang, Mingkai Ji
AIM: The objective of this study was to evaluate the effects of seed oil of Caragana korshinskii Kom. against Trichophyton mentagrophytes on an in vivo guinea pig model of dermatophytosis. METHODS: The skin of albino guinea pigs was infected with T. mentagrophytes, and the animals were divided into five groups: negative control (NC group), positive control (PC group), vehicle control, CK50% group (received topical 50% seed oil of C.korshinskii), and CK100% group (received topical 100% seed oil of C...
2016: Skin Pharmacology and Physiology
Anna Färber, Rolf Daniels
Triterpenes of the outer bark of birch are known to improve wound healing. An oleogel with these triterpenes as active principle is approved by the European Medicines Agency. As foams can be applied without touching the skin, they might be an advantageous application form. A comparable wound-healing effect can be expected when the permeation flux of the triterpenes from different types of formulations, namely oleogels, water-in-oil emulsions and water-in-oil foams, is similar. The tested formulations were based on three lipids (medium-chain trigylcerides, sunflower oil and paraffin) which differ in their polarity and solvent power for the triterpenes...
2016: Skin Pharmacology and Physiology
Mami Yokota, Yoshihiro Tokudome
BACKGROUND/AIMS: Advanced glycation end products, which are linked to both aging and hyperglycemia, cause marked functional and structural alterations in human skin. Though it is well known that the metabolism of glucose is closely associated with that of fatty acid (FA), sharing the same energy-yielding reaction pathways as glucose, its effect on the epidermis has been unclear so far. METHODS: Content of ceramides, cholesterol and FA in a reconstructed epidermal model glycated by glyoxal was analyzed by high-performance thin-layer chromatography...
2016: Skin Pharmacology and Physiology
Hassaan Tohid, Daniyal Aleem, Chantal Jackson
OBJECTIVE: The aim of this paper was to highlight the mechanisms involved and the relationship between depression and psoriasis. METHOD: A comprehensive literature search was performed in various databases, and finally 88 studies were deemed relevant. RESULTS: A significant link was found between depression and psoriasis, primarily through immune mechanisms related but not limited to the actions of inflammatory cytokines such as tumor necrosis factor-α, interleukin 1 (IL-1), IL-2, IL-10, interferon-γ, IL-1β, prostaglandin E2, C-reactive protein, IL-6, and IL-8...
2016: Skin Pharmacology and Physiology
Antonella Casiraghi, Umberto M Musazzi, Paolo Rocco, Silvia Franzè, Paola Minghetti
BACKGROUND/AIM: Topical β-blockers have recently been proposed as a valid alternative to oral drugs for treating cutaneous infantile haemangiomas, but clinical results in the literature are inconsistent due to the empirical choice of topical preparations. The current investigation aimed to rationalize the selection of a semi-solid vehicle for a locally applied drug product containing 1% w/w propranolol hydrochloride (PR-Cl). METHODS: A hydrophobic ointment of PR-Cl, two lipophilic creams, and a hydrophilic cream were prepared...
2016: Skin Pharmacology and Physiology
Gunhyuk Park, Dal-Seok Oh, Yong-Ung Kim, Moon-Ki Park
BACKGROUND/AIMS: Wound healing is a complex regeneration process involving the degradation and reassembly of connective tissues and skin layers. Previous studies have shown that pH plays a significant role in both the direct and indirect regulation of cellular processes in the wound, which, in turn, affect the wound healing process. However, the effects of pH on the collagen breakdown component of wound healing have yet to be investigated. Therefore, we investigated the induction of accelerated collagen breakdown by pH imbalance in the skin...
2016: Skin Pharmacology and Physiology
Jazli Aziz, Hafiz Shezali, Zamri Radzi, Noor Azlin Yahya, Noor Hayaty Abu Kassim, Jan Czernuszka, Mohammad Tariqur Rahman
Collagen and elastin networks make up the majority of the extracellular matrix in many organs, such as the skin. The mechanisms which are involved in the maintenance of homeostatic equilibrium of these networks are numerous, involving the regulation of genetic expression, growth factor secretion, signalling pathways, secondary messaging systems, and ion channel activity. However, many factors are capable of disrupting these pathways, which leads to an imbalance of homeostatic equilibrium. Ultimately, this leads to changes in the physical nature of skin, both functionally and cosmetically...
2016: Skin Pharmacology and Physiology
Iman Seleit, Ola Ahmed Bakry, Hala Saed El Repey, Raghdaa Ali
Skin is a target organ of sex steroids which play important roles in skin health and disease. The aim of this study is to investigate the expression of estrogen receptor β (ERβ) and androgen receptor (AR) in human skin from different age groups for a better understanding of the hormonal regulation of skin aging. Using standard immunohistochemical techniques, biopsies of sun-unprotected and sun-protected skin were taken from 60 normal subjects. Sun-protected skin showed significantly higher immunoreactivity for ERβ and AR compared to sun-unprotected skin of all age groups...
2016: Skin Pharmacology and Physiology
Estibalitz Fernández, Lluís Fajarí, Gelen Rodríguez, Mercedes Cócera, Verónica Moner, Lucyanna Barbosa-Barros, Christina S Kamma-Lorger, Alfonso de la Maza, Olga López
AIM: In this work the effect of infrared (IR) radiation, at temperatures between 25 and 30°C, on the formation of free radicals (FRs) in the skin is studied. Additionally, the influence of IR radiation at high temperatures in the degradation of skin collagen is evaluated. In both experiments the protective effect against IR radiation of phospholipid nanostructures (bicosomes) incorporating β-carotene (Bcb) is also evaluated. METHODS: The formation of FRs in skin under IR exposure was measured near physiological temperatures (25-30°C) using 5,5-dimethyl-1-pyrroline-N-oxide spin trap and electron paramagnetic resonance (EPR) spectroscopy...
2016: Skin Pharmacology and Physiology
Schapoor Hessam, Michael Sand, Dimitrios Georgas, Agnes Anders, Falk G Bechara
BACKGROUND: The role of bacterial colonization in hidradenitis suppurativa (HS) lesions is poorly understood. To date, data on the related microbial profile and especially on bacterial resistance rates are scarce. METHODS: The results of bacterial cultures and susceptibility patterns of the isolated microorganisms obtained from deep portions of HS lesions from patients who underwent surgery at our HS Centre between 2010 and 2015 were retrospectively evaluated. RESULTS: Analyses of 113 bacterial samples from 113 HS patients revealed bacterial growth in 95 samples (84...
2016: Skin Pharmacology and Physiology
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