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Veterinary and Comparative Oncology

Min-Ok Ryu, Byung-Gak Kim, Ul Soo Choi, Kwan-Hyuck Baek, Young-Ki Song, Qiang Li, Kyung-Won Seo, Sandra Ryeom, Hwa-Young Youn, Dong Ha Bhang
Protein kinase A, a cyclic AMP-dependent enzyme, normally exists within mammalian cells; however, in cancer cells, it can leak out and be found in the serum. Extracellular cyclic AMP-dependent protein kinase A (ECPKA) has been determined to increase in the serum of cancer-bearing dogs. However, there have been no reports in the veterinary literature on serum ECPKA autoantibody (ECPKA-Ab) expression in dogs with cancer. The aim of this study was to evaluate ECPKA-Ab and C-reactive protein (CRP) as serum biomarkers for cancer in dogs...
November 8, 2018: Veterinary and Comparative Oncology
S Favril, E Stock, S Hernot, M Hesta, I Polis, K Vanderperren, H de Rooster
Sentinel lymph node (SLN) mapping is a valuable and crucial diagnostic procedure in staging malignancies. We compared two non-invasive techniques, near-infrared (NIR) fluorescence imaging and contrast-enhanced ultrasound (CEUS), to identify the SLNs in 3 superficial anatomical regions in an animal model. Six healthy laboratory dogs were included in a proof-of-concept trial. A NIR fluorescent dye (Indocyanine Green) and microbubbles (Sonovue) were consecutively injected subdermally in the inguinal, axillary, and popliteal region to map the SLNs...
October 11, 2018: Veterinary and Comparative Oncology
Caroline R Reckelhoff, Amandine Lejeune, Patrick M Thompson, Keijiro Shiomitsu
Paccal Vet (Osamia Pharmaceuticals) is a water-soluble nanoparticle micellar formulation of the drug paclitaxel that is well tolerated in dogs. This study evaluated the in vitro effect of Paccal Vet on two canine hemangiosarcoma (HSA) cell lines and their expression of vascular endothelial growth factor (VEGF) and basic fibroblast growth factor (bFGF). Paccal Vet caused HSA cell death in a dose- and time-dependent manner. The 50% inhibitory concentration (IC50 ) for the two HSA cell lines were 7 to 610 ng/mL, which are clinically achievable...
September 28, 2018: Veterinary and Comparative Oncology
Katelyn W Marlowe, Cecilia S Robat, Dawn L Clarke, Angela Taylor, Maude Touret, Brian D Husbands, David M Vail
Primary pulmonary histiocytic sarcoma (PHS) has been reported, but is not well characterized. The aim of this retrospective study was to describe clinical characteristics, characterize prognostic factors and report the outcome of a larger group of dogs with primary PHS. Medical records of dogs diagnosed with primary PHS at 11 institutions were retrospectively reviewed. Thirty-seven dogs were included; 13 received CCNU-based chemotherapy alone, 18 received surgery and adjuvant CCNU-based chemotherapy, 3 received medical management alone and 3 dogs received surgery alone...
September 23, 2018: Veterinary and Comparative Oncology
Kosei Sakai, Shingo Maeda, Kohei Saeki, Takayuki Nakagawa, Mami Murakami, Yoshifumi Endo, Tomohiro Yonezawa, Tsuyoshi Kadosawa, Takashi Mori, Ryohei Nishimura, Naoaki Matsuki
Transitional cell carcinoma (TCC) accounts for >90% of canine malignant tumours occurring in urinary bladder, and the prognosis is poor. Our previous study, using RNA sequencing, showed that human epidermal growth factor 2 (HER2) was the most activated upstream regulator related to carcinogenesis in canine TCC. The aim of this study was to examine the anti-tumour effect of lapatinib, a tyrosine kinase inhibitor of HER2, on canine TCC cell lines in vitro and in vivo. Five canine TCC cell lines (TCCUB, Love, Sora, LCTCC, and MCTCC) were used...
September 23, 2018: Veterinary and Comparative Oncology
Laura E Selmic, Jonathan Samuelson, Jennifer K Reagan, Kelly J Mesa, Elizabeth Driskell, Joanne Li, Marina Marjanovic, Stephen A Boppart
Optical coherence tomography (OCT) is a rapid non-invasive imaging technique that has shown high sensitivity for intraoperative surgical margin assessment in human breast cancer clinical trials. This promising technology has not been evaluated in veterinary medicine. The objective of this study was to correlate normal and abnormal histological features with OCT images for surgical margins from excised canine soft tissue sarcoma (STS) and to establish image evaluation criteria for identifying positive surgical margins...
September 21, 2018: Veterinary and Comparative Oncology
Genevieve Hartley, Robyn Elmslie, Brent Murphy, Leone Hopkins, Amanda Guth, Steven Dow
Cancer relapse following chemotherapy has been attributed in part to the presence of cancer stem cells (CSC), which drive tumor growth and metastasis and are highly resistant to the effects of cytotoxic chemotherapy. As a result, treatment with cytotoxic chemotherapy selects for drug-resistant CSC populations that eventually drive tumor recurrence. Little is known currently regarding the role of CSC in dogs with lymphoma, nor the impact of chemotherapy on CSC populations. Therefore, we prospectively quantitated CSC populations in dogs with B cell and T cell lymphoma, using tumor aspirates and flow cytometric analysis with a panel of CSC markers...
September 20, 2018: Veterinary and Comparative Oncology
Sangho Kim, Kenji Hosoya, Ayumi Kobayashi, Masahiro Okumura
Peripheral blood stem cell (PBSC) transplantation following consolidation therapy is a feasible treatment option for canine hematological malignancies. In veterinary medicine, hematopoietic stem cells are generally mobilized into peripheral circulation using a granulocyte colony stimulating factor (G-CSF). This pilot study aimed to evaluate the hematopoietic stem cell mobilization effect of three different regimens for PBSC apheresis with Spectra Optia continuous mononuclear cell (CMNC) protocol in healthy dogs...
September 17, 2018: Veterinary and Comparative Oncology
Hyeri Shin, Aryung Nam, Kun-Ho Song, Kupil Lee, Robert B Rebhun, Kyoung-Won Seo
The use of the well-known powerful antioxidant ascorbate has recently become more widespread in human medicine. Intravenous administration of high-dose ascorbate has been demonstrated to exert anticancer effects. It has resulted in effective cell death in vitro and inhibition of tumour growth in vivo. The aim of the current study was to evaluate the effects of high-dose ascorbate on canine melanoma in vitro. Four canine melanoma cell lines, UCDK9M1, UCDK9M3, UCDK9M4 and UCDK9M5 were treated with ascorbate for 2 hours at a range of millimolar concentrations (0-20 mM) to investigate the resulting effects on cell viability...
September 6, 2018: Veterinary and Comparative Oncology
Kim A Selting, Sandra M Bechtel, Jahna Espinosa, Carolyn J Henry, Deborah Tate, Jeffrey N Bryan, Lian Rajewski, Brian K Flesner, Charles Decedue, Michael Baltezor
Carriers used to solubilize taxane chemotherapy drugs cause severe hypersensitivity. Nanoparticle formulations can provide improved dissolution and bioavailability of taxanes. Thus, a nanoparticulate, excipient-free formulation of paclitaxel (CTI52010) was evaluated in tumour-bearing dogs with intravenous and subcutaneous delivery. Tumour-bearing dogs were treated with intravenous CTI52010 using a modified rapid dose escalation scheme. Subcutaneous administration was then planned for a small cohort of dogs for comparison...
September 4, 2018: Veterinary and Comparative Oncology
Ana Canadas, Marta Santos, Ricardo Pinto, Rui Medeiros, Patrícia Dias-Pereira
The enzyme catechol-o-methyltransferase (COMT) is responsible for inactivation of catechol estrogens, which are well-recognized carcinogenic metabolites. Two single-nucleotide polymorphisms (SNPs) in canine COMT gene were previously associated with the age of onset of mammary tumours and with the clinical progression of the disease. However, no information is available regarding the impact of other known SNPs in COMT gene in canine mammary tumours. The aim of the present study is to evaluate the influence of COMT SNP in clinicopathological features and outcome of canine mammary tumours...
August 30, 2018: Veterinary and Comparative Oncology
Sita S Withers, Katherine A Skorupski, Daniel York, Jin W Choi, Kevin D Woolard, Renee Laufer-Amorim, Ellen E Sparger, Carlos O Rodriguez, Stephen J McSorley, Arta M Monjazeb, William J Murphy, Robert J Canter, Robert B Rebhun
Immunotherapeutic strategies have shown promise for the treatment of canine osteosarcoma (cOSA). Very little is known about the immune microenvironment within cOSA, however, limiting our ability to identify potential immune targets and biomarkers of therapeutic response. We therefore prospectively assessed the disease-free interval (DFI) and overall survival time (ST) of 30 dogs with cOSA treated with amputation and six doses of adjuvant carboplatin. We then quantified lymphocytic (CD3+, FOXP3+) and macrophage (CD204+) infiltrates within the primary tumours of this cohort using immunohistochemistry, and evaluated their association with outcome...
August 28, 2018: Veterinary and Comparative Oncology
Matthew James Woodruff, Kathryn L Heading, Peter Bennett
Few veterinary studies have evaluated the response to chemotherapy treatment of canine intranasal tumours, while many have focused on the efficacy of radiation therapy. Given the higher costs and limited access to radiation therapy, alternative treatment options are needed. The study describes a cohort of dogs with histologically confirmed intranasal tumours treated with chemotherapy as a sole therapy. This retrospective study was conducted using data from the Melbourne Veterinary Specialist Centre (MVSC) database between 2004 and 2017...
August 26, 2018: Veterinary and Comparative Oncology
Michael Willmann, Emir Hadzijusufovic, Olivier Hermine, Mauro Dacasto, Laura Marconato, Karin Bauer, Barbara Peter, Susanne Gamperl, Gregor Eisenwort, Erika Jensen-Jarolim, Mathias Müller, Michel Arock, David M Vail, Peter Valent
In humans, advanced mast cell (MC) neoplasms are rare malignancies with a poor prognosis. Only a few preclinical models are available and current treatment options are limited. In dogs, MC neoplasms are the most frequent malignant skin tumors. Unlike low-grade MC neoplasms, high-grade MC disorders usually have a poor prognosis with short survival. In both species, neoplastic MCs display activating KIT mutations which are considered to contribute to disease evolution. Therefore, tyrosine kinase inhibitors against KIT have been developed...
August 22, 2018: Veterinary and Comparative Oncology
Valeria Meier, Jürgen Besserer, Malgorzata Roos, Carla Rohrer Bley
Previous trials showed the importance of administering radiation therapy (RT) with small doses per fraction in canine pelvic tumours to maintain acceptable toxicity levels. With increased accuracy/precision of RT, namely intensity-modulated RT (IMRT), this approach might be challenged. Theoretical toxicity calculations for a new definitive-intent moderately hypofractionated RT protocol for canine anal sac adenocarcinomas (ASAC) were performed, focussing on the risk of toxicity in pelvic organs at risk (OAR)...
August 22, 2018: Veterinary and Comparative Oncology
Yi-Chen Chen, Ying-Yu Chen, Jiunn-Wang Liao, Shih-Chieh Chang
C-met is a receptor normally expressed on epithelial cells and dysregulated in human breast cancers. Mammary tumours are the most common tumour in female dogs. The aims of this study were to detect the expression of c-met in canine mammary tumours (CMTs) and evaluate the correlations between c-met expression and clinicopathological features. A total of 240 specimens of canine mammary tissues composed of 30 normal glands, 30 hyperplastic ones, 90 benign tumours and 90 carcinomas obtained from 127 bitches were examined by immunohistochemical staining...
August 20, 2018: Veterinary and Comparative Oncology
(no author information available yet)
No abstract text is available yet for this article.
December 2018: Veterinary and Comparative Oncology
Sita S Withers, Daniel York, Eric Johnson, Sami Al-Nadaf, Katherine A Skorupski, Carlos O Rodriguez, Jenna H Burton, Teri Guerrero, Kriste Sein, Luke Wittenburg, Robert B Rebhun
Curcumin has well-established anti-cancer properties in vitro, however, its therapeutic potential has been hindered by its poor bioavailability. Lipocurc is a proprietary liposome-encapsulated curcumin formulation that enables intravenous delivery and has been shown to reach its highest concentration within lung tissue. The goal of this study was to characterize the anti-cancer and anti-angiogenic activity of Lipocurc in vitro, in addition to evaluating Lipocurc infusions in dogs with naturally occurring cancer...
December 2018: Veterinary and Comparative Oncology
(no author information available yet)
No abstract text is available yet for this article.
September 2018: Veterinary and Comparative Oncology
J L Bisson, D J Argyle, S A Argyle
Bacterial infection following cancer chemotherapy-induced neutropenia is a serious cause of morbidity and mortality in human and veterinary patients. Antimicrobial prophylaxis is controversial in the human oncology field, as any decreased incidence in bacterial infections is countered by patient adverse effects and increased antimicrobial resistance. Comprehensive guidelines exist to aid human oncologists in prescribing antimicrobial prophylaxis but similar recommendations are not available in veterinary literature...
September 2018: Veterinary and Comparative Oncology
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