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Veterinary and Comparative Oncology

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https://www.readbyqxmd.com/read/28419683/geographical-differences-in-survival-of-dogs-with-non-hodgkin-lymphoma-treated-with-a-chop-based-chemotherapy-protocol
#1
H Wilson-Robles, C M Budke, T Miller, N Dervisis, A Novosad, Z Wright, D H Thamm, K Vickery, K Burgess, M Childress, J Lori, C Saba, S Rau, M Silver, G Post, K Reeds, S Gillings, S Schleis, T Stein, B Brugmann, C DeRegis, O Smrkovski, J Lawrence, T Laver
BACKGROUND: In humans geographical differences in the incidence and presentation of various cancers have been reported. However, much of this information has not been collected in veterinary oncology. AIM: The purpose of this study was to determine if a geographic difference in progression free survival exists for dogs with lymphoma treated within the US. MATERIALS AND METHODS: Medical records of 775 cases of canine lymphoma from 3 US regions (west, south and north), treated with CHOP chemotherapy, were retrospectively evaluated...
April 17, 2017: Veterinary and Comparative Oncology
https://www.readbyqxmd.com/read/28419676/efficacy-of-dacarbazine-as-a-rescue-agent-for-histiocytic-sarcoma-in-dogs
#2
K A Kezer, L G Barber, S H Jennings
BACKGROUND: Canine histiocytic sarcoma (HS) is an aggressive neoplasm that is generally associated with a poor prognosis. CCNU is considered first-line medical therapy, although the majority of dogs ultimately develop progressive disease. The objective of this study was to evaluate the efficacy of dacarbazine as a rescue agent for HS. MATERIALS AND METHODS: Medical records of dogs diagnosed with HS that received at least one dose of dacarbazine were reviewed. Information collected and analyzed included signalment, disease distribution, treatment history, dacarbazine treatments (including dose, interval and total number of cycles), adverse events, and response to treatment...
April 17, 2017: Veterinary and Comparative Oncology
https://www.readbyqxmd.com/read/28397975/the-jak2-stat5-signaling-pathway-as-a-potential-therapeutic-target-in-canine-mastocytoma
#3
Alexandra Keller, Bettina Wingelhofer, Barbara Peter, Karin Bauer, Daniela Berger, Susanne Gamperl, Martin Reifinger, Sabine Cerny-Reiterer, Richard Moriggl, Michael Willmann, Peter Valent, Emir Hadzijusufovic
BACKGROUND: Mastocytoma are frequently diagnosed cutaneous neoplasms in dogs. In non-resectable mastocytoma patients, novel targeted drugs are often applied. The transcription factor STAT5 has been implicated in the survival of human neoplastic mast cells (MC). Our study evaluated the JAK2/STAT5 pathway as a novel target in canine mastocytoma. MATERIALS AND METHODS: We employed inhibitors of JAK2 (R763, TG101348, AZD1480, ruxolitinib) and STAT5 (pimozide, piceatannol) and evaluated their effects on 2 mastocytoma cell lines, C2 and NI-1...
April 11, 2017: Veterinary and Comparative Oncology
https://www.readbyqxmd.com/read/28371355/bosutinib-an-src-inhibitor-induces-caspase-independent-cell-death-associated-with-permeabilization-of-lysosomal-membranes-in-melanoma-cells
#4
S Noguchi, S Shibutani, K Fukushima, T Mori, M Igase, T Mizuno
BACKGROUND: SRC kinase (SRC proto-oncogene, non-receptor tyrosine kinase) is a promising target for the treatment of solid cancers including human melanoma. Bosutinib (Bosu), a SRC inhibitor, has already been applied to the treatment of human chronic myelogenous leukemia and also has been assessed its safety in dogs. AIM: The aim of this study was to clarify a novel anti-tumour mechanism of Bosu in canine and human melanoma cells. MATERIALS AND METHODS: The canine and human melanoma cells were treated with Bosu and its effects were evaluated by the cell viability, the protein expression levels such as caspase-3 and LC3, Annexin V/Propidium iodide staining, and confocal immunostaining...
March 28, 2017: Veterinary and Comparative Oncology
https://www.readbyqxmd.com/read/28370855/effectiveness-of-co2-laser-in-an-experimental-mammary-gland-adenocarcinoma-model
#5
J Paczuska, M Świtalska, M Nowak, Z Kiełbowicz
BACKGROUND: The important goal of modern research in the field of surgical oncology is the quest for a tool that could improve the outcomes of tumour excision. AIMS: The aim of this study was to compare the usefulness of the CO2 laser with flexible hollow waveguide and scalpel in mammary tumour excision. MATERIALS & METHODS: A total of 112 female BALB/c mice with implanted orthotopically 4T1-luc2-tdTomato tumour cells were included in the research...
March 28, 2017: Veterinary and Comparative Oncology
https://www.readbyqxmd.com/read/28322030/melatonin-and-il-25-modulate-apoptosis-and-angiogenesis-mediators-in-metastatic-cf-41-and-non-metastatic-cmt-u229-canine-mammary-tumour-cells
#6
G B Gelaleti, T F Borin, L B Maschio-Signorini, M G Moschetta, E Hellmén, A M Viloria-Petit, D A P C Zuccari
BACKGROUND: Melatonin has oncostatic actions and IL-25 is active in inflammatory processes that induce apoptosis in tumor cells AIM: The aim of this study was to evaluate melatonin and IL-25 in metastatic (CF-41) and non-metastatic (CMT-U229) canine mammary tumor cells cultured as monolayers and tridimensional structures. MATERIALS AND METHODS: The cells were treated with melatonin, IL-25 and IL-17B silencing gene and performed cell viability, gene and protein expression of caspase-3 and VEGFA (Vascular endothelial growth factor A) and an apoptosis membrane protein array...
March 20, 2017: Veterinary and Comparative Oncology
https://www.readbyqxmd.com/read/28317239/the-use-of-low-dose-metronomic-chemotherapy-in-dogs-insight-into-a-modern-cancer-field
#7
REVIEW
T B Gaspar, J Henriques, L Marconato, F L Queiroga
The era of chemotherapy, which started in the middle of the last century, has been ruled by the routine use of dose-intense protocols, based on the "maximum-tolerated dose" concept. By promoting a balance between patient's quality of life and the goal of rapidly killing as many tumour cells as possible, these protocols still play a prominent role in veterinary oncology. However, with the opening of a new millennium, metronomic chemotherapy (MC) started to be considered a possible alternative to traditional dose-intense chemotherapy...
March 20, 2017: Veterinary and Comparative Oncology
https://www.readbyqxmd.com/read/28233400/features-and-prognostic-impact-of-distant-metastases-in-45-dogs-with-de-novo-stage-iv-cutaneous-mast-cell-tumours-a-prospective-study
#8
S Pizzoni, S Sabattini, D Stefanello, A Dentini, R Ferrari, M Dacasto, M Giantin, P Laganga, M Amati, G Tortorella, L Marconato
BACKGROUND: Distant metastases in dogs with cutaneous mast cell tumors (cMCT) are rare and incurable. The aims of this prospective study were to clarify the clinico-pathological features of stage IV cMCTs and to identify possible prognostic factors for progression-free interval (PFI) and survival time (ST). MATERIAL AND METHODS: Dogs were eligible for recruitment if they had a previously untreated, histologically confirmed cMCT and if they underwent complete staging demonstrating stage IV disease...
February 23, 2017: Veterinary and Comparative Oncology
https://www.readbyqxmd.com/read/28220614/comparative-analysis-of-dna-methylation-patterns-of-equine-sarcoid-and-healthy-skin-samples
#9
E Semik, T Ząbek, A Gurgul, A Fornal, T Szmatoła, K Pawlina, M Wnuk, J Klukowska-Rötzler, C Koch, K Mählmann, M Bugno-Poniewierska
OBJECTIVE: In this study, for the first time we report the genome-wide DNA methylation profile of skin tumour in horses and describe differentially methylated genomic regions (DMRs) with respect to healthy skin. MATERIALS & METHODS: The comparative analysis of DNA methylation patterns detected using Reduced Representation Bisulfite Sequencing (RRBS) technique, allowed identification of 136 regions showing differential methylation between sarcoid and normal skin tissue...
February 21, 2017: Veterinary and Comparative Oncology
https://www.readbyqxmd.com/read/28217972/clinical-outcome-of-partial-cystectomy-for-transitional-cell-carcinoma-of-the-canine-bladder
#10
S J Marvel, B Séguin, D D Dailey, D H Thamm
Canine transitional cell carcinoma (TCC) of the bladder has historically been treated with a combination of chemotherapy, cyclooxygenase inhibitors and radiation therapy. While surgery has been used to treat TCC of the bladder, its efficacy has yet to be established. Thirty-seven client owned dogs that underwent partial cystectomy +/- various nonsurgical treatments for TCC were retrospectively evaluated. The overall median progression-free interval (PFI) was 235 days and the median survival time (ST) was 348 days...
February 20, 2017: Veterinary and Comparative Oncology
https://www.readbyqxmd.com/read/28194921/surgical-margins-in-the-veterinary-cancer-patient
#11
REVIEW
M Milovancev, D S Russell
In veterinary oncologic specimens, histopathology is the gold standard for determining adequacy of excision. Despite limitations of this technique, the pathologist's interpretation of margin status significantly impacts patient management, including indications for adjuvant therapy. This article aims to summarize peer-reviewed literature as it relates to histologic margin evaluation in veterinary cancer patients. The value of histologic tumour-free margins and technical factors influencing histopathologic margin outcomes are also discussed...
February 14, 2017: Veterinary and Comparative Oncology
https://www.readbyqxmd.com/read/28194917/furosemide-for-prevention-of-cyclophosphamide-associated-sterile-haemorrhagic-cystitis-in-dogs-receiving-metronomic-low-dose-oral-cyclophosphamide
#12
L Setyo, M Ma, T Bunn, K Wyatt, P Wang
Sterile haemorrhagic cystitis (SHC) is a known risk of cyclophosphamide treatment. Diuresis using furosemide is effective in canines when maximally tolerated dosed cyclophosphamide is administered. This retrospective study aimed to determine whether orally administered furosemide decreased the incidence of SHC. Secondary aims were to identify predisposing factors for SHC. One-hundred and fifteen dogs treated with metronomic cyclophosphamide were analysed retrospectively. Populations were not randomized. 25 dogs (21...
February 14, 2017: Veterinary and Comparative Oncology
https://www.readbyqxmd.com/read/28185388/characteristics-of-extracellular-cyclic-amp-dependent-protein-kinase-as-a-biomarker-of-cancer-in-dogs
#13
D H Bhang, U S Choi, B G Kim, S-N Lee, S Lee, H-S Roh, W-J Chung, K O Jeon, W J Song, H-Y Youn, K-H Baek
OBJECTIVE: Early and proper diagnosis of cancer is the most critical factor for the survival and treatment of veterinary cancer patients. In this study, we evaluated extracellular cyclic AMP-dependent protein kinase A (ECPKA) level in serum as a useful cancer biomarker in dogs. METHODS: ECPKA levels were detected in sera from dogs with cancers (n = 48), benign tumours (n = 18), and non-tumour diseases (n = 102) as well as healthy control dogs (n = 54) utilizing enzyme-linked immunosorbent assay (ELISA)...
February 9, 2017: Veterinary and Comparative Oncology
https://www.readbyqxmd.com/read/28168776/treatment-outcomes-and-prognostic-factors-of-feline-splenic-mast-cell-tumors-a-multi-institutional-retrospective-study-of-64-cases
#14
B J Evans, D O'Brien, S D Allstadt, T P Gregor, K U Sorenmo
BACKGROUND: Mast cell tumors (MCT) are common splenic tumors in cats, but there is limited information on treatment outcomes of cats with this disease. MATERIALS AND METHODS: This retrospective study evaluated treatment outcomes in 64 cats with splenic MCT. Cats were categorized into the following treatment groups: splenectomy (A, n = 20); splenectomy with chemotherapy (B, n = 20); chemotherapy alone (C, n = 15); or supportive care (D, n = 9). RESULTS: Median tumor specific survival (MTSS) was: 856, 853, 244, 365 days for groups A, B, C, and D, respectively...
February 7, 2017: Veterinary and Comparative Oncology
https://www.readbyqxmd.com/read/28150469/targeting-canine-mammary-tumours-via-gold-nanoparticles-functionalized-with-promising-co-ii-and-zn-ii-compounds
#15
L R Raposo, C Roma-Rodrigues, J Jesus, L M D R S Martins, A J Pombeiro, P V Baptista, A R Fernandes
BACKGROUND: Despite continuous efforts, the treatment of canine cancer has still to deliver effective strategies. For example, traditional chemotherapy with doxorubicin and/or docetaxel does not significantly increase survival in dogs with canine mammary tumors (CMTs). AIMS: Evaluate the efficiency of two metal compounds [Zn(DION)2 ]Cl (TS262, DION = 1,10-phenanthroline-5,6-dione) and [CoCl(H2 O)(DION)2 ][BF4 ] (TS265) and novel nanovectorizations designed to improve the anti-cancer efficacy of these compounds in a new CMT derived cell line (FR37-CMT)...
February 2, 2017: Veterinary and Comparative Oncology
https://www.readbyqxmd.com/read/28150446/evaluation-of-the-modified-glasgow-prognostic-score-to-predict-outcome-in-dogs-with-newly-diagnosed-lymphoma
#16
S J Fontaine, E McCulloch, P D Eckersall, H Haining, J C Patterson Kane, J S Morris
The modified Glasgow Prognostic Score (mGPS) assigns a numerical value (0-2) from pre-treatment serum concentrations of C-reactive protein (CRP) and albumin to predict patient outcome. CRP and albumin were evaluated in 77 untreated dogs with lymphoma to determine the relationship of mGPS to clinicopathological parameters and whether it could predict progression-free (PFS) and overall survival (OS) in treated dogs. mGPS distribution was significantly associated with clinical stage, substage b, weight loss, gastrointestinal disturbances and lethargy at presentation...
February 2, 2017: Veterinary and Comparative Oncology
https://www.readbyqxmd.com/read/28133930/in-vitro-evaluation-of-selective-inhibitors-of-nuclear-export-sine-drugs-kpt-185-and-kpt-335-against-canine-mammary-carcinoma-and-transitional-cell-carcinoma-tumor-initiating-cells
#17
J E Grayton, T Miller, H Wilson-Robles
No abstract text is available yet for this article.
January 30, 2017: Veterinary and Comparative Oncology
https://www.readbyqxmd.com/read/28133886/somatic-snps-of-the-brca2-gene-at-the-fragments-encoding-rad51-binding-sites-of-canine-mammary-tumors
#18
O Ozmen, S Kul, A Risvanli, G Ozalp, A Sabuncu, O Kul
Mammary tumors are the most common tumor type both in women and in female dogs. In women, heritable breast cancers have been linked mutations in the breast cancer susceptibility gene BRCA2 and it contains eight BRC repeats in exon 11 that bind to RAD51. In this study, we investigated the sequence variations of BRC1-BRC8 and C-terminus of canine BRCA2 gene. From a total of 64 canine patients with mammary tumors, 31 mammary tumors with benign and malign carcinomas and the 3 normal mammary glands were used for the study...
January 30, 2017: Veterinary and Comparative Oncology
https://www.readbyqxmd.com/read/28133880/intra-and-inter-observer-agreement-in-histological-assessment-of-canine-soft-tissue-sarcoma
#19
F W Yap, R Rasotto, S L Priestnall, K J Parsons, J Stewart
BACKGROUND: The diagnosis of canine soft tissue sarcoma (STS) is based on histological assessment. Assessment of criteria such as, degree of differentiation, necrosis score and mitotic score, gives rise to a final tumour grade, which is important in the recommendation of treatment and prognosis of patients. MATERIALS AND METHODS: Previously diagnosed cases of STS were independently assessed by three board-certified veterinary pathologists. Participating pathologists were blinded to the original results...
January 30, 2017: Veterinary and Comparative Oncology
https://www.readbyqxmd.com/read/26300342/post-radiotherapy-hypothyroidism-in-dogs-treated-for-thyroid-carcinomas
#20
I Amores-Fuster, P Cripps, L Blackwood
Hypothyroidism is a common adverse event after head and neck radiotherapy in human medicine, but uncommonly reported in canine patients. Records of 21 dogs with histologically or cytologically confirmed thyroid carcinoma receiving definitive or hypofractionated radiotherapy were reviewed. Nine cases received 48 Gy in 12 fractions, 10 received 36 Gy in 4 fractions and 2 received 32 Gy in 4 fractions. Seventeen cases had radiotherapy in a post-operative setting. Ten cases developed hypothyroidism (47.6%) after radiotherapy...
March 2017: Veterinary and Comparative Oncology
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