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Veterinary and Comparative Oncology

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https://www.readbyqxmd.com/read/27813229/characterization-of-a-pcr-based-lymphocyte-clonality-assay-as-a-complementary-tool-for-the-diagnosis-of-feline-lymphoma
#1
S E Hammer, S Groiss, A Fuchs-Baumgartinger, N Nedorost, V Gress, N Luckschander-Zeller, A Saalmüller, I Schwendenwein, B C Rütgen
Differentiation between resident mature lymphocyte populations and small cell lymphoma cannot be made by cytological review alone and remains challenging in histopathological review. These cases warrant application of complementary tools like PCR-based immunoglobulin (IG) and T-cell receptor (TCR) clonality testing for confirmation. In this prospective study, diagnostic sensitivity and specificity of different primer sets for routine diagnosis of feline TCR gamma (TCRG) and complete IG heavy chain (IGH) gene rearrangements were assessed...
November 4, 2016: Veterinary and Comparative Oncology
https://www.readbyqxmd.com/read/27779366/immunohistochemical-expression-of-mdr1-pgp-170-in-canine-cutaneous-and-oral-melanomas-pattern-of-expression-and-association-with-tumour-location-and-phenotype
#2
R Finotello, J M Monné Rodriguez, M Vilafranca, J Altimira, G A Ramirez, A Haines, L Ressel
Canine melanoma (CMM) more commonly affects the oral mucosa and the cutis. CMM shares several features with human melanomas (HMM), included resistance to a broad variety of antineoplastic chemotherapy agents. P-glycoprotein 1 (Pgp) expression is a well-recognized feature of multi-drug resistance and the purpose of this study was to investigate its expression in treatment naïve CMM. We also investigated Pgp association with tumour location and histological features. Histology records of CMM were retrieved, including patients from 2012-2014...
October 25, 2016: Veterinary and Comparative Oncology
https://www.readbyqxmd.com/read/27779365/transcriptome-analysis-of-equine-sarcoids
#3
E Semik, A Gurgul, T Ząbek, K Ropka-Molik, C Koch, K Mählmann, M Bugno-Poniewierska
Equine sarcoids are the most commonly detected skin tumours in Equidae. In the present research, a comparative transcriptomic analysis was performed which aimed at looking inside a tumour biology and identification of the expression profile as a potential source of cancer specific genes useful as biomarkers. We have used Horse Gene Expression Microarray data from matched equine sarcoids and tumour-distant skin samples. In total, 901 significantly differentially expressed genes (DEGs) between lesional and healthy skin samples have been identified (fold change ≥ 2; P < 0...
October 25, 2016: Veterinary and Comparative Oncology
https://www.readbyqxmd.com/read/27779362/role-of-monocyte-recruitment-in-hemangiosarcoma-metastasis-in-dogs
#4
D P Regan, A Escaffi, J Coy, J Kurihara, S W Dow
Canine hemangiosarcoma (HSA) is a highly malignant tumour associated with short survival times because of early and widespread metastasis. In humans and rodents, monocytes play key roles in promoting tumour metastasis through stimulating tumour cell extravasation, seeding, growth and angiogenesis. Therefore, we investigated the potential association between monocyte infiltration and tumour metastasis in HSA and other common canine tumours. Immunohistochemistry was used to quantify CD18(+) monocytes within metastases...
October 25, 2016: Veterinary and Comparative Oncology
https://www.readbyqxmd.com/read/27723224/pretreatment-leukocyte-ratios-and-concentrations-as-predictors-of-outcome-in-dogs-with-cutaneous-mast-cell-tumours
#5
O Skor, A Fuchs-Baumgartinger, A Tichy, M Kleiter, I Schwendenwein
Leukocyte ratios correlate with outcome in several human cancers. Little is known about their prognostic significance in mast cell tumour (MCT). The aim of the study was to evaluate the prognostic significance of pretreatment leukocyte concentrations and their ratios in dogs with MCT for survival. Medical records of 92 dogs with MCT were retrospectively reviewed. Tumour diagnosis was made by tumour biopsy or fine-needle aspirate. Only dogs without prior treatment were included. Eosinophil, lymphocyte, monocyte and neutrophil concentration were obtained by ADVIA 2120™ (Siemens Healthcare, Vienna, Austria)...
October 9, 2016: Veterinary and Comparative Oncology
https://www.readbyqxmd.com/read/27714960/risk-factors-for-treatment-related-adverse-events-in-cancer-bearing-dogs-receiving-piroxicam
#6
L R Eichstadt, G E Moore, M O Childress
Piroxicam has antitumour effects in dogs with cancer, although side effects may limit its use. The purpose of this study was to retrospectively identify factors predisposing cancer-bearing dogs to adverse events (AEs) following piroxicam therapy. Medical records of dogs presented to the Purdue Veterinary Teaching Hospital between 2005 and 2015 were reviewed, and 137 dogs met the criteria for study inclusion. Toxic effects of piroxicam in these dogs were graded according to an established system. Multivariate logistic regression was used to estimate the extent to which certain factors affected the risk for AEs...
October 6, 2016: Veterinary and Comparative Oncology
https://www.readbyqxmd.com/read/27714944/sequence-analysis-of-ras-and-raf-mutation-hot-spots-in-canine-carcinoma
#7
H Mochizuki, M Breen
Recent discovery of the BRAF V595E mutation in a variety of canine cancers indicates that mutant BRAF may represent a novel therapeutic target. Presence of RAS mutations is associated with poor tumour response to BRAF inhibition but has not been investigated in BRAF-mutated canine cancers. The aim of this study was to evaluate the mutational status of three RAS genes (HRAS, KRAS and NRAS) in four types of canine carcinoma with and without the BRAF V595E mutation. Novel HRAS mutations were identified in 18% (3/17) of oral squamous cell carcinoma, whereas 17% (3/18) of pulmonary carcinoma carried KRAS or NRAS mutations...
October 6, 2016: Veterinary and Comparative Oncology
https://www.readbyqxmd.com/read/27714908/lymph-node-histology-for-the-assessment-of-residual-neoplastic-disease-in-canine-mast-cell-tumours-does-the-presence-of-metachromatic-granules-always-identify-mast-cells
#8
L Ressel, R Finotello
No abstract text is available yet for this article.
October 6, 2016: Veterinary and Comparative Oncology
https://www.readbyqxmd.com/read/27714906/retrospective-evaluation-of-blood-copper-stable-isotopes-ratio-65-cu-63-cu-as-a-biomarker-of-cancer-in-dogs
#9
G Chamel, A T Gourlan, P Télouk, D Sayag, V Milliard, C Loiseau, M Simon, S Buff, F Ponce
Previous studies in humans with breast, colorectal or liver cancer showed that neoplasia was associated with a modification of the blood ratio between (65) Cu and (63) Cu (∂Cu). The aim of the present study was to compare the blood ∂Cu of dogs with cancer to healthy controls or dogs with non-oncologic disease. One hundred and seventeen dogs were included in the study (35 dogs with cancer, 33 dogs with non-neoplastic disease, and 49 healthy controls). The ∂Cu of dogs with cancer was significantly lower than the ratio of healthy controls (P < 0...
October 6, 2016: Veterinary and Comparative Oncology
https://www.readbyqxmd.com/read/27696684/a-literature-review-of-reports-of-the-stability-and-storage-of-common-injectable-chemotherapy-agents-used-in-veterinary-patients
#10
C M Chan, A E Frimberger, A S Moore
Many chemotherapy drugs used in human patients are discarded after single use or within 24 h of reconstitution, as per the manufacturer's product label recommendations. This can be wasteful and costly to veterinary clients. This report reviews the published stability and storage data for 19 injectable chemotherapy drugs commonly used in veterinary medicine. Based on these data, storage procedures are presented, assuming aseptic technique and a closed system drug transfer device (CSDTD) are used for drug preparation and handling...
October 2, 2016: Veterinary and Comparative Oncology
https://www.readbyqxmd.com/read/27481030/cover-image-volume-14-issue-3
#11
Filippo Scarpa, Silvia Sabattini, Giuliano Bettini
The cover image, by Giuliano Bettini et al., is based on the Original Article Cytological grading of canine cutaneous mast cell tumours, DOI: 10.1111/vco.12090.
September 2016: Veterinary and Comparative Oncology
https://www.readbyqxmd.com/read/25112808/identification-of-drug-resistant-subpopulations-in-canine-hemangiosarcoma
#12
A Khammanivong, B H Gorden, A M Frantz, A J Graef, E B Dickerson
Canine hemangiosarcoma is a rapidly progressive disease that is poorly responsive to conventional chemotherapy. Despite numerous attempts to advance treatment options and improve outcomes, drug resistance remains a hurdle to successful therapy. To address this problem, we used recently characterized progenitor cell populations derived from canine hemangiosarcoma cell lines and grown as non-adherent spheres to identify potential drug resistance mechanisms as well as drug-resistant cell populations. Cells from sphere-forming cultures displayed enhanced resistance to chemotherapy drugs, expansion of dye-excluding side populations and altered ATP-binding cassette (ABC) transporter expression...
September 2016: Veterinary and Comparative Oncology
https://www.readbyqxmd.com/read/25082554/semiquantitative-immunohistochemical-marker-staining-and-localization-in-canine-thyroid-carcinoma-and-normal-thyroid-gland
#13
P Pessina, V Castillo, I Sartore, J Borrego, A Meikle
Immunoreactive proteins in follicular cells, fibroblasts and endothelial cells were assessed in canine thyroid carcinomas and healthy thyroid glands. No differences were detected in thyrotropin receptor and thyroglobulin staining between cancer and normal tissues, but expression was higher in follicular cells than in fibroblasts. Fibroblast growth factor-2 staining was more intense in healthy follicular cells than in those of carcinomas. Follicular cells in carcinomas presented two- to three-fold greater staining intensity of thyroid transcription factor-1 and proliferating cell nuclear antigen, respectively, than healthy cells, and a similar trend was found for the latter antigen in fibroblasts...
September 2016: Veterinary and Comparative Oncology
https://www.readbyqxmd.com/read/25070729/radioresistance-of-cancer-stem-like-cell-derived-from-canine-tumours
#14
A Tanabe, T Deguchi, T Sato, Y Nemoto, T Maruo, H Madarame, T Shida, Y Naya, K Ogihara, H Sahara
Cancer stem-like cells (CSCs)/cancer-initiating cells (CICs) are a small subpopulation of cancer cells that are responsible for the initiation, recurrence and metastasis of cancer. We previously demonstrated that, using the Hoechst 33342 dye-based side population technique, CSCs/CICs in canine lung adenocarcinoma cell line exist. In this study, as CSCs/CICs are known to form spheres in anchorage-independent environment in vitro, we evaluated the stemness of spheroid cells derived from canine lung adenocarcinoma and osteosarcoma cells by expression of stemness markers, and investigated radioresistance...
September 2016: Veterinary and Comparative Oncology
https://www.readbyqxmd.com/read/25041580/safety-of-intrathecal-administration-of-cytosine-arabinoside-and-methotrexate-in-dogs-and-cats
#15
S Genoni, V Palus, S Eminaga, G B Cherubini
The objective of the study was to retrospectively evaluate the short-term safety of intrathecal administration of cytosine arabinoside alone or in combination with methotrexate in dogs and cats. One hundred and twelve dogs and eight cats admitted between September 2008 and December 2013, diagnosed with suspected inflammatory (meningoencephalomyelitis of unknown aetiology) or neoplastic disease affecting brain or spinal cord and treated with an intrathecal administration of cytosine arabinoside alone or in combination with methotrexate were included in the study...
September 2016: Veterinary and Comparative Oncology
https://www.readbyqxmd.com/read/25041470/of-mice-and-men-olfactory-neuroblastoma-among-animals-and-humans
#16
REVIEW
A Lubojemska, M Borejko, P Czapiewski, R Dziadziuszko, W Biernat
Olfactory neuroblastoma (ONB) is a rare tumour of nasal cavity and paranasal sinuses that arises from the olfactory neuroepithelium and has unpredictable clinical course. As the sense of smell is phylogenetically one of the first senses and olfactory neuroepithelium is evolutionary conserved with striking similarities among different species, we performed an extensive analysis of the literature in order to evaluate the similarities and differences between animals and humans on the clinical, morphological, immunohistochemical, ultrastructural and molecular level...
September 2016: Veterinary and Comparative Oncology
https://www.readbyqxmd.com/read/25041357/serum-25-hydroxyvitamin-d-concentrations-in-dogs-correlation-with-health-and-cancer-risk
#17
K A Selting, C R Sharp, R Ringold, D H Thamm, R Backus
25-hydroxyvitamin D (25(OH)D) is important in bone health as well as many diseases including cancer. Supplementation may increase responsiveness of cancer cells to chemotherapy. Serum 25(OH)D, intact parathyroid hormone (iPTH) and canine C-reactive protein (c-CRP) were measured in healthy dogs and dogs with haemoabdomen. Regression analysis determined optimal 25(OH)D concentrations. In healthy dogs (n = 282), mean iPTH concentrations correlated inversely (r(2) = 0.88, P < 0.001) to 25(OH)D concentrations...
September 2016: Veterinary and Comparative Oncology
https://www.readbyqxmd.com/read/24976305/vegfr-2-expression-in-malignant-tumours-of-the-canine-mammary-gland-a-prospective-survival-study
#18
A Santos, C Lopes, F Gärtner, A J F Matos
Vascular endothelial growth factor receptor-2 (VEGFR-2) is the main receptor activated by vascular endothelial growth factor -A (VEGF-A) to promote tumour angiogenesis. Its clinical prognostic value has not been studied in canine mammary tumours (CMTs). Dogs with mammary cancer were enrolled in a survival study and the immunohistochemical expressions of VEGFR-2 and VEGF-A were analysed and associated with clinicopathological features. VEGFR-2 expression was associated with VEGF immunoreactivity in cancer cells, supporting the presence of an autocrine loop that may be involved in CMTs growth and survival...
September 2016: Veterinary and Comparative Oncology
https://www.readbyqxmd.com/read/24976212/in-vitro-effects-of-yunnan-baiyao-on-canine-hemangiosarcoma-cell-lines
#19
K A Wirth, K Kow, M E Salute, N J Bacon, R J Milner
Yunnan Baiyao is a Chinese herbal medicine that has been utilized for its anti-inflammatory, haemostatic, wound healing and pain relieving properties in people. It has been utilized in the veterinary profession to control bleeding in dogs with hemangiosarcoma (HSA) and has been anecdotally reported to prolong survival times in dogs with this neoplasm. This study evaluated the in vitro activity of Yunnan Baiyao against three canine HSA cell lines after treatment with increasing concentrations of Yunnan Baiyao (50, 100, 200, 400, 600 and 800 µg mL(-1) ) at 24, 48 and 72 h...
September 2016: Veterinary and Comparative Oncology
https://www.readbyqxmd.com/read/24945683/a-comparison-of-clinical-magnetic-resonance-imaging-and-pathological-findings-in-dogs-with-gliomatosis-cerebri-focusing-on-cases-with-minimal-magnetic-resonance-imaging-changes-%C3%A2
#20
R T Bentley, G N Burcham, H G Heng, J M Levine, R Longshore, S Carrera-Justiz, S Cameron, K Kopf, M A Miller
The primary study objective was to determine whether clinical examination and magnetic resonance imaging (MRI) can underestimate canine gliomatosis cerebri (GC); we also investigated immunohistochemical features. Seven dogs with GC were studied; four recruited specifically because of minimal MRI changes. Neuroanatomic localization and the distribution of MRI, gross and sub-gross lesions were compared with the actual histological distribution of neoplastic cells. In six cases, clinical examination predicted focal disease and MRI demonstrated a single lesion or appeared normal...
September 2016: Veterinary and Comparative Oncology
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