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Expert Review of Cardiovascular Therapy

journal
https://www.readbyqxmd.com/read/28730857/controversies-in-complex-percutaneous-coronary-intervention-radial-versus-femoral
#1
Ian C Gilchrist, Stephen O Awuor, Rhian E Davies, Anene C Ukaigwe
Evolution in the technology used in the cardiac catheterization laboratory has permitted a migration from the femoral to radial artery access for many interventional procedures while concurrently improving outcomes. As a disruptive technology, transradial access has been associated with several controversies including a dichotomous relationship with femoral access. Areas covered: Several different patient subsets along with perceived technical challenges in interventional cardiology are reviewed with regard to the issue of access site...
July 21, 2017: Expert Review of Cardiovascular Therapy
https://www.readbyqxmd.com/read/28728443/functional-assessment-of-coronary-artery-disease-by-cardiac-computed-tomography
#2
T A Treibel, A Rossi, F Pugliese, C Davies
Rapid technological advances in computed tomography (CT) have allowed CT coronary angiography (CTCA) to be delivered at low radiation dose and high diagnostic accuracy. Due to its high negative predictive value for coronary artery disease, it has become a gatekeeper for the assessment of patients with chest pain of recent onset. Second line functional assessment of a detected coronary stenosis relies mostly on other imaging modalities. Functional assessment of coronary artery disease by CT is therefore an attractive addition to CTCA...
July 21, 2017: Expert Review of Cardiovascular Therapy
https://www.readbyqxmd.com/read/28724320/statins-and-venous-thromboembolism-do-they-represent-a-viable-therapeutic-agent
#3
Setor K Kunutsor, Michael R Whitehouse, Ashley W Blom, Jari A Laukkanen
Venous thromboembolism (VTE) is an important cause of preventable morbidity and mortality. Though anticoagulants are effective in preventing VTE, they are associated with major bleeding risk. The 3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors (known as statins), are well established for the primary and secondary prevention of cardiovascular disease via their lipid-lowering properties. Emerging evidence suggests that statins may play a role in the prevention of VTE, but the evidence has been uncertain...
July 21, 2017: Expert Review of Cardiovascular Therapy
https://www.readbyqxmd.com/read/28724329/new-heart-failure-pharmacotherapy-in-clinical-trials-a-hope-in-progress
#4
Ahmed Selim, Ronald Zolty, Yiannis S Chatzizisis
No abstract text is available yet for this article.
July 20, 2017: Expert Review of Cardiovascular Therapy
https://www.readbyqxmd.com/read/28724315/persistent-atrial-fibrillation-vs-paroxysmal-atrial-fibrillation-differences-in-management
#5
Andrei D Margulescu, Lluis Mont Girbau
Atrial fibrillation (AF) is the most common human arrhythmia. AF is a progressive disease, initially being nonsustained and induced by trigger activity, and progressing towards persistent AF through alteration of the atrial myocardial substrate. Treatment of AF aims to decrease the risk of stroke and improve the quality of life, by preventing recurrences (rhythm control) or controlling the heart rate during AF (rate control). In the last 20 years, catheter-based and, less frequently, surgical and hybrid ablation techniques have proven more successful compared with drug therapy in achieving rhythm control in patients with AF...
July 20, 2017: Expert Review of Cardiovascular Therapy
https://www.readbyqxmd.com/read/28718666/atrial-cardiopathy-a-mechanism-of-cryptogenic-stroke
#6
Shadi Yaghi, Hooman Kamel, Mitchell S V Elkind
Cryptogenic stroke accounts for approximately 30% of all ischemic strokes. Recently, atrial cardiopathy diagnosed by the presence of one of its serum, imaging, or electrocardiogram biomarkers has been shown to be associated with ischemic stroke, particularly of embolic subtypes. Areas covered: This paper aims to summarize data on occult atrial fibrillation and stroke, provide an overview on mechanisms, such as inflammation and fibrosis, of stroke in atrial cardiopathy, critically review data on biomarkers of atrial cardiopathy and their association with stroke, and suggest therapeutic implications, including directions for future research...
July 18, 2017: Expert Review of Cardiovascular Therapy
https://www.readbyqxmd.com/read/28714796/effect-of-bariatric-surgery-on-heart-failure
#7
Marcela Rodriguez Flores, Carlos Aguilar Salinas, Marie-Eve Piché, Audrey Auclair, Paul Poirier
Obesity increases the risk of heart failure (HF), which continues to be a significant proportion of all cardiovascular diseases and affects increasingly younger populations. The cross-talk between adipose and the heart involves insulin resistance, adipokine signaling and inflammation, with the capacity of adipose tissue to mediate hemodynamic signals, promoting progressive cardiomyopathy. Areas covered: From a therapeutic perspective, there is not yet a single obesity-related pathway that when addressed, can ameliorate cardiomyopathy in obese patients and this is a matter of ongoing research...
July 17, 2017: Expert Review of Cardiovascular Therapy
https://www.readbyqxmd.com/read/28712328/knowledge-of-hypertension-and-its-management-among-hypertensive-patients-on-chronic-medicines-at-primary-health-care-public-sector-facilities-in-south-africa-findings-and-implications
#8
E M Rampamba, J C Meyer, E Helberg, B Godman
BACKGROUND: High and growing prevalence rates of hypertension in South Africa. Consequently, there is a need to assess knowledge and management among hypertensive patients receiving chronic medication from primary health care (PHC) facilities in South Africa as a basis for improving future management. This is important as South Africa seeks to improve its management of chronic diseases. METHOD: Descriptive, quantitative study amongst chronic hypertensive patients in the chronic disease programme...
July 17, 2017: Expert Review of Cardiovascular Therapy
https://www.readbyqxmd.com/read/28699807/personalizing-antiplatelet-prescribing-using-genetics-for-patients-undergoing-percutaneous-coronary-intervention
#9
Larisa H Cavallari
Clopidogrel is commonly prescribed with aspirin to reduce the risk for adverse cardiovascular events after percutaneous coronary intervention (PCI). However, there is significant inter-patient variability in clopidogrel response. The CYP2C19 enzyme is involved in the biotransformation of clopidogrel to its pharmacologically active form, and variation in the CYP2C19 gene contributes to clopidogrel response variability. Areas covered. This article describes the impact of CYP2C19 genotype on clopidogrel pharmacokinetics, pharmacodynamics, and effectiveness...
July 12, 2017: Expert Review of Cardiovascular Therapy
https://www.readbyqxmd.com/read/28699363/response-to-letter-bear-tracks-hypothesis-from-atrial-fibrillation-to-atrial-fibrosis-syndrome-in-stroke-risk-assessment
#10
Louisa O'Neill, James Harrison, Mark O'Neill, Steven E Williams
No abstract text is available yet for this article.
July 12, 2017: Expert Review of Cardiovascular Therapy
https://www.readbyqxmd.com/read/28697653/bear-tracks-hypothesis-from-atrial-fibrillation-to-atrial-fibrosis-syndrome-in-stroke-risk-assessment
#11
Ozcan Ozeke, Serkan Cay, Firat Ozcan, Ayten Hacili, Serkan Topaloglu, Dursun Aras
No abstract text is available yet for this article.
July 12, 2017: Expert Review of Cardiovascular Therapy
https://www.readbyqxmd.com/read/28691589/gender-and-atrial-fibrillation-what-role-for-real-world-registry-data
#12
Sylvia Haas
No abstract text is available yet for this article.
July 10, 2017: Expert Review of Cardiovascular Therapy
https://www.readbyqxmd.com/read/28657444/bridging-the-gap-for-lipid-lowering-therapy-plaque-regression-coronary-computed-tomographic-angiography-and-imaging-guided-personalized-medicine
#13
Alan C Kwan, Konstantinos N Aronis, Veit Sandfort, Roger S Blumenthal, David A Bluemke
Lipid-lowering therapy effectively decreases cardiovascular risk on a population level, but it remains difficult to identify an individual patient's personal risk reduction while following guideline directed medical therapy, leading to overtreatment in some patients and cardiovascular events in others. Recent improvements in cardiac CT technology provide the ability to directly assess an individual's atherosclerotic disease burden, which has the potential to personalize risk assessment for lipid-lowering therapy...
July 6, 2017: Expert Review of Cardiovascular Therapy
https://www.readbyqxmd.com/read/28656875/remote-monitoring-of-heart-failure-benefits-for-therapeutic-decision-making
#14
Mihran Martirosyan, Kadir Caliskan, Dominic A M J Theuns, Tamas Szili-Torok
Chronic heart failure is a cardiovascular disorder with high prevalence and incidence worldwide. The course of heart failure is characterized by periods of stability and instability. Decompensation of heart failure is associated with frequent and prolonged hospitalizations and it worsens the prognosis for the disease and increases cardiovascular mortality among affected patients. It is therefore important to monitor these patients carefully to reveal changes in their condition. Remote monitoring has been designed to facilitate an early detection of adverse events and to minimize regular follow-up visits for heart failure patients...
July 6, 2017: Expert Review of Cardiovascular Therapy
https://www.readbyqxmd.com/read/28618840/cardiac-surgery-in-solid-organ-transplant-recipients-a-clinical-challenge
#15
Mina Farag, Marina Nikolic, Alexander Weymann
Due to continuous improvement of transplant medicine, the number of solid organ transplant recipients in need of cardiac surgery is constantly growing. The objective of this work was to compare different reports on outcomes in patients with previous solid organ transplant after cardiac surgery. Areas covered: Published studies containing data about solid organ transplant recipients: renal, hepatic, pancreas or combined were identified through med-line research. Reported outcomes were categorized according to short- and long term-follow up and the presence or absence of a match-group...
July 5, 2017: Expert Review of Cardiovascular Therapy
https://www.readbyqxmd.com/read/28656784/the-spectrum-of-mitral-valve-pathologies-relevance-for-surgical-and-structural-interventions
#16
Sho Torii, Maria E Romero, Hiroyoshi Mori, Emanuel Harari, Frank D Kolodgie, Aloke V Finn, Renu Virmani
The mitral valve apparatus, both functionally and morphologically is composed of a constellation of individual structures, including the annulus, anterior and posterior leaflets, chordae tendineae, and papillary muscles. Most also include the left ventricular wall and the left atrium which are essential for the valve to function normally. Areas covered: The commonest conditions responsible for mitral valve dysfunction in the Western World are degenerative and functional mitral regurgitation, which are discussed in detail...
July 4, 2017: Expert Review of Cardiovascular Therapy
https://www.readbyqxmd.com/read/28651464/are-the-pcsk9-inhibitors-the-panacea-of-atherosclerosis-treatment
#17
Evan A Stein, Traci A Turner
No abstract text is available yet for this article.
July 4, 2017: Expert Review of Cardiovascular Therapy
https://www.readbyqxmd.com/read/28591518/intra-operative-mapping-of-the-atria-the-first-step-towards-individualization-of-atrial-fibrillation-therapy
#18
Charles Kik, Elisabeth M J P Mouws, Ad J J C Bogers, Natasja M S de Groot
Atrial fibrillation (AF), an age-related progressive disease, is becoming a worldwide epidemic with a prevalence rate of 33 million. Areas covered: In this expert review, an overview of important results obtained from previous intra-operative mapping studies is provided. In addition, our novel intra-operative high resolution mapping studies, its surgical considerations and data analyses are discussed. Furthermore, the importance of high resolution mapping studies of both sinus rhythm and AF for the development of future AF therapy is underlined by our most recent results...
June 15, 2017: Expert Review of Cardiovascular Therapy
https://www.readbyqxmd.com/read/28475386/achieving-blood-pressure-targets-for-prolonged-cardiovascular-health-a-historical-perspective
#19
Steven G Chrysant
Hypertension is a major risk factor for coronary artery disease (CAD), stroke, heart failure, and chronic kidney disease (CKD), and its successful control leads to a decrease or prevention of these complications. Areas covered: Over the years the Joint National Committees and the American Heart Association have issued guidelines regarding the treatment of hypertension. Those of 2003 and 2007 respectively, have recommended reduction of blood pressure (BP) to < 140/90 mmHg for uncomplicated hypertension and to < 130/80 mmHg for hypertensive patients with diabetes mellitus, CKD, or CAD...
May 15, 2017: Expert Review of Cardiovascular Therapy
https://www.readbyqxmd.com/read/28571513/a-pulmonary-embolism-response-team-initial-experiences-and-future-directions
#20
Emily K Zern, Michael N Young, Kenneth Rosenfield, Christopher Kabrhel
Acute pulmonary embolism (PE) is a common cardiovascular condition resulting in significant morbidity and mortality. Consensus recommendations suggest risk stratification of patients into three main categories: high-risk or 'massive' PE, intermediate-risk or 'submassive' PE, and low-risk PE. Given the relative dearth of prospective, randomized clinical trials delineating optimal selection of the diverse medical, interventional, and surgical treatment approaches, clinical care requires a multidisciplinary expert approach to patients with PE...
June 2017: Expert Review of Cardiovascular Therapy
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