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Expert Review of Cardiovascular Therapy

Aung Myat, Udaya S Tantry, Jacek Kubica, Paul A Gurbel
Introduction A P2Y12 inhibitor plus aspirin is the most widely used antiplatelet strategy to prevent adverse outcomes in the setting of atherothrombotic vascular disease. Areas Covered A paucity of robust evidence for an optimal dose, gastrointestinal toxicity, ineffectiveness in high-risk patients and interactions with other antiplatelet agents, are major controversies associated with aspirin therapy. Ticagrelor is a reversibly binding oral P2Y12 receptor blocker that mediates potent inhibition of adenosine diphosphate-induced platelet function...
October 14, 2016: Expert Review of Cardiovascular Therapy
Benilde Cosmi
Idiopathic or unprovoked venous thromboembolism is an event occurring in the absence of any apparent provoking or triggering environmental risk factors, such as surgery, trauma, and immobilization. Areas covered: Unprovoked VTE can be associated with occult cancer, but only limited, and not extensive cancer screening, may be warranted, as the rate of occult cancer is low in such patients. Routine thrombophilia testing is not currently recommended as it does not influence the management of the disease. The duration of anticoagulation for unprovoked VTE after the first three months is still debated as the disease tends to recur regardless of treatment duration...
October 14, 2016: Expert Review of Cardiovascular Therapy
Ashan Gunarathne, Shahana Hussain, Anthony H Gershlick
Dual antiplatelet therapy (DAPT) with aspirin combined with either a thienopyridine (clopidogrel or prasugrel) or acyclopentyl-triazolo-pyrimidine (ticagrelor) plays a vital role in the management of acute coronary syndrome (ACS) especially in those undergoing percutaneous coronary intervention (PCI) but even those being managed medically. Observational studies and some formal studies have shown patients on the standard dual antiplatelet regimen (clopidogrel and aspirin) continue to have further ischemic events and can suffer stent thrombosis...
October 4, 2016: Expert Review of Cardiovascular Therapy
Daniela Cardinale, Carlo Maria Cipolla
No abstract text is available yet for this article.
September 21, 2016: Expert Review of Cardiovascular Therapy
Marco Barbanti, Giuseppe Gargiulo, Corrado Tamburino
INTRODUCTION: Transcatheter aortic valve implantation (TAVI) underwent progressive improvements until it became the default therapy for inoperable patients, and a recommended therapy in high-risk operable patients with symptomatic severe aortic stenosis. Recent evidence will further support TAVI as treatment for a growing number of patients. AREAS COVERED: This review will discuss on the current knowledge about the role of both pre-procedural chronic kidney disease (CKD) and post-procedural acute kidney injury (AKI) in adult patients with severe aortic stenosis undergoing TAVI...
September 20, 2016: Expert Review of Cardiovascular Therapy
Lucas S Zier, Horst Sievert, Vaikom S Mahadevan
INTRODUCTION: Patent foramen ovale (PFO) is a common congenital cardiac abnormality and that has been associated with several disease processes including transient ischemic attacks (TIA), stroke, migraine headaches with aura, decompression sickness, platypnea-orthodeoxia syndrome, and shunt induced cyanosis. Controversy exists regarding closure of PFO as a therapeutic treatment modality for these disease processes. This review addresses the contemporary clinical indications for PFO closure...
September 10, 2016: Expert Review of Cardiovascular Therapy
Anouk J W Gulpen, Arina J Ten Cate-Hoek, Hugo Ten Cate
INTRODUCTION: For a long time, vitamin K antagonists (VKA) have been the preferred drugs for the anticoagulation management of both atrial fibrillation and venous thromboembolism. Hereby, the major purpose is to attenuate the onset of thrombosis without affecting hemostasis. AREAS COVERED: Nowadays, non-vitamin K anticoagulants (NOAC), a new class of oral anticoagulants is available for the above-mentioned indications. NOAC are at least as effective and safer with regard to intracranial bleedings compared to VKA, but major bleedings still occur...
August 30, 2016: Expert Review of Cardiovascular Therapy
Maria Drakopoulou, Konstantinos Toutouzas, Konstantinos Stathogiannis, Andreas Synetos, George Trantalis, Dimitrios Tousoulis
INTRODUCTION: Lipid profile management is even more critical in patients treated for secondary prevention, since patients with established coronary heart disease are at higher risk of developing events. Current guidelines encourage lifestyle modification and patient engagement in disease prevention. However, the American College of Cardiology/American Heart Association guidelines seem to differ considerably from their predecessors, having an impact on clinical practice of lipid management...
August 23, 2016: Expert Review of Cardiovascular Therapy
Cao Thach Tran, Hugh Calkins
INTRODUCTION: Over the past 10-15 years, there has been an increasing amount of evidence that frequent premature ventricular contractions (PVCs) are associated with the development of a reversible cardiomyopathy. AREAS COVERED: This review considers current evidence of the association between PVCs and the development of cardiomyopathy, risk factors, and available treatment modalities based on available published literature. Expert commentary: The field is rapidly evolving, although evidence is based primarily on observational studies...
August 23, 2016: Expert Review of Cardiovascular Therapy
Martin Gester, Elif Peker, Eike Nagel, Valentina O Puntmann
INTRODUCTION: Cardiac involvement in systemic inflammatory diseases (SID) has a major impact on patients' morbidity and mortality, yet the pathways to its recognition and management remain poorly established. AREAS COVERED: Overall clinical management in SID patients is primarily guided by systemic symptoms. Cardiovascular disease goes largely undetected, as it evolves through years of a protracted and subclinical course. Despite the increased awareness and insights into the mechanistic role of the inflammatory pathways, clinical management of cardiac involvement continues to rely on diagnostic means, which are frequently insensitive, inaccurate, invasive and rely on radiation exposure...
August 19, 2016: Expert Review of Cardiovascular Therapy
Lucia Venneri, Rajdeep S Khattar
No abstract text is available yet for this article.
August 19, 2016: Expert Review of Cardiovascular Therapy
Ioannis Dimarakis
INTRODUCTION: Cardiopulmonary bypass has undoubtedly been the cornerstone in the rapid development of cardiac surgery, allowing even the performance of procedures beyond the scope of cardiothoracic surgery. Its use however, is associated with significant complications that arise from the mechanical effects of the circuit on circulating blood components as well as the contact of blood with non-endothelial surfaces. Miniature cardiopulmonary bypass systems have been developed in an attempt to minimize these complications...
August 19, 2016: Expert Review of Cardiovascular Therapy
Jason T Jacobson, Sei Iwai, Wilbert Aronow
INTRODUCTION: Recurrent ventricular arrhythmias (VA) are a source of significant morbidity in patients without structural heart disease (SHD) and also mortality in patients with SHD. The treatment goals for these two patient populations differ greatly. AREAS COVERED: The secondary prevention of recurrent VA in patients without and with SHD will be reviewed, focusing on clinical data (especially randomized, controlled trials) in the literature as determined through searches in PubMed and ClinicalTrials...
August 5, 2016: Expert Review of Cardiovascular Therapy
Suvitesh Luthra
No abstract text is available yet for this article.
July 27, 2016: Expert Review of Cardiovascular Therapy
Corbin E Goerlich, O H Frazier, William E Cohn
No abstract text is available yet for this article.
October 2016: Expert Review of Cardiovascular Therapy
Michael Sagner, Ross Arena, Amy McNeil, Ginnela N V Brahmam, Andrew P Hills, H Janaka De Silva, R P Palitha Karunapema, Chandrika N Wijeyaratne, Carukshi Arambepola, Pekka Puska
INTRODUCTION: The current burden and future escalating threat of chronic diseases, constitutes the major global public health challenge. In Sri Lanka, cardiovascular diseases account for the majority of annual deaths. Data from Sri Lanka also indicate a high incidence and prevalence of pre-diabetes and diabetes; 1 in 5 adults have elevated blood sugar in Sri Lanka. It is well established that chronic diseases share four primary behavioral risk factors: 1) tobacco use; 2) unhealthy diet; 3) physical inactivity; and 4) harmful use of alcohol...
October 2016: Expert Review of Cardiovascular Therapy
Christos Pappas, John Lekakis, Dimitrios Alexopoulos
No abstract text is available yet for this article.
October 2016: Expert Review of Cardiovascular Therapy
Niccolò Lombardi, Giada Crescioli, Alessandro Mugelli, Alfredo Vannacci
No abstract text is available yet for this article.
October 2016: Expert Review of Cardiovascular Therapy
Maria Grazia Bongiorni, Andrea Di Cori, Luca Segreti, Giulio Zucchelli, Stefano Viani, Luca Paperini, Francesca Menichetti, Giovanni Coluccia, Ezio Soldati
INTRODUCTION: Transvenous lead extraction (TLE) is the gold standard for lead removal. The increasing rate of cardiac implantable electronic device (CIED) implantations and of CIED related complications highlight the importance of transvenous lead extraction . AREAS COVERED: The TLE scenario is constantly changing. Optimizing lead related technology and improving TLE practice across the world are the cornerstones to improving safety and efficacy. We review the state of the art in TLE, focusing on potential future implications and improvements in terms of skills and technologies...
October 2016: Expert Review of Cardiovascular Therapy
Rhodri King, Ramzi Ajjan
No abstract text is available yet for this article.
October 2016: Expert Review of Cardiovascular Therapy
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