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Expert Review of Cardiovascular Therapy

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https://www.readbyqxmd.com/read/28076988/ischemic-stroke-risk-in-east-asian-patients-with-cha2ds2-vasc-score-of-1-systematic-review-and-meta-analysis
#1
Ying Bai, Alena Shantsila, Gregory Y H Lip
Background The use of anticoagulation for stroke prevention in patients with atrial fibrillation (AF) and CHA2DS2-VASc score of 1 has been debated, partially due to limited data on ischemic stroke risk and specific clinical trials in these patients. East Asian patients have a different stroke risk profile compared to non-East Asians. We performed a systematic review and meta-analysis of ischemic stroke risk in AF patients with a CHA2DS2-VASc score of 1 in East Asian countries. Methods A comprehensive literature search for studies evaluating ischemic stroke risk related with AF with CHA2DS2-VASc score of 1 was conducted by two reviewers...
January 11, 2017: Expert Review of Cardiovascular Therapy
https://www.readbyqxmd.com/read/28076699/infective-endocarditis-prophylaxis-a-review
#2
Benson Njuguna, Francois Delahaye
Guidelines for prophylaxis against infective endocarditis (IE) have changed significantly due to a lack of evidence for its efficacy and increasing concerns about safety and antibiotic resistance. The impact of these changes on clinical practice and IE hospitalisation trends and outcomes has become a focus of research. Areas Covered: We review the rationale for and against IE prophylaxis, highlight significant changes in guidelines since 2002, and discuss literature examining the impact of these changes on antibiotic prescription rates for IE prophylaxis, IE incidence, morbidity, and mortality...
January 11, 2017: Expert Review of Cardiovascular Therapy
https://www.readbyqxmd.com/read/28056579/corrigendum
#3
(no author information available yet)
No abstract text is available yet for this article.
January 5, 2017: Expert Review of Cardiovascular Therapy
https://www.readbyqxmd.com/read/28005450/the-ecg-in-the-differential-diagnosis-between-takotsubo-cardiomyopathy-and-acute-coronary-syndrome
#4
Federico Guerra, Irene Giannini, Alessandro Capucci
Takotsubo cardiomyopathy (TC) is an acquired cardiomyopathy affecting mostly postmenopausal women mimicking an acute coronary syndrome (ACS). TC clinical presentation involves chest pain, elevated cardiac enzymes, wall motion abnormalities and electrocardiographic changes, all of which share striking similarities to ACS. Areas covered: Differential diagnosis between TC and ACS can be complex since there are no reliable and widely-accepted electrocardiographic criteria and, at the moment, only coronary angiography can rule out one of the two diagnoses with good certainty...
December 29, 2016: Expert Review of Cardiovascular Therapy
https://www.readbyqxmd.com/read/28010154/anti-inflammatory-drugs-as-promising-cardiovascular-treatments
#5
Fabien Huet, Mariama Akodad, Jérémy Fauconnier, Alain Lacampagne, François Roubille
Inflammation is a well-known powerful effector of atherosclerosis development. Cell infiltration induces inflammatory signal increasing plaque formation as well as its destabilization, leading to cardiovascular disease including myocardial infarction. During ischemia, necrotic cardiomyocytes stimulate the inflammatory storm into the myocardium (by chemokines, vascular adhesion molecules, interleukins action) promoting cardiac repair but also remodeling. Areas covered: Herein the authors present each condition (atherosclerosis and myocardial infarction) in two separate parts...
December 28, 2016: Expert Review of Cardiovascular Therapy
https://www.readbyqxmd.com/read/28004599/drug-therapy-for-ectopic-fat-myth-or-reality
#6
Niki Katsiki, Pablo Perez-Martinez
No abstract text is available yet for this article.
December 28, 2016: Expert Review of Cardiovascular Therapy
https://www.readbyqxmd.com/read/27983887/does-the-evidence-really-suggest-that-we-should-completely-revascularise-bystander-disease-in-patients-with-st-elevation-myocardial-infarction-undergoing-primary-angioplasty-why-we-still-need-more-definitive-trial-data-to-change-routine-practice
#7
Mark Mariathas, Bartosz Olechowski, Michael Mahmoudi, Nick Curzen
There remains considerable heterogeneity in the management of significant lesions in non culprit coronary arteries in STEMI patients undergoing primary percutaneous coronary intervention (PPCI). Three recent randomised trials have shown clinical outcome benefit in a complete revascularisation approach when compared to PPCI of the culprit artery alone. By contrast, observational data suggest that an aggressive complete revascularisation may not confer clinical benefit and may, in some cases, be harmful. Areas covered: In this review we discuss the three recent randomised trials that have advocated a complete revasculariation approach in addition to data available from registries...
December 27, 2016: Expert Review of Cardiovascular Therapy
https://www.readbyqxmd.com/read/28002972/response-to-drug-therapy-for-ectopic-fat-myth-or-reality
#8
Amalia Gastaldelli, Melania Gaggini
No abstract text is available yet for this article.
December 26, 2016: Expert Review of Cardiovascular Therapy
https://www.readbyqxmd.com/read/27977305/what-is-the-role-of-sutureless-aortic-valves-in-today-s-armamentarium
#9
Dimos Karangelis, Amine Mazine, Apostolos Roubelakis, Christos Alexiou, Socrates Fragoulis, C David Mazer, Bobby Yanagawa, David Latter, Daniel Bonneau
Sutureless and rapid-deployment aortic bioprostheses represent an emerging and promising technology for the treatment of aortic valve stenosis. Unlike traditional aortic bioprostheses, these devices are not hand-sewn, thus allowing a significant reduction in operative times, while facilitating minimally invasive surgery and complex cardiac interventions. Sutureless aortic valve replacement represents a less invasive treatment option and an excellent alternative to conventional aortic valve replacement in elderly and higher risk patients...
December 26, 2016: Expert Review of Cardiovascular Therapy
https://www.readbyqxmd.com/read/27780367/the-role-of-multi-modality-imaging-in-selecting-patients-and-guiding-lead-placement-for-the-delivery-of-cardiac-resynchronization-therapy
#10
Jonathan M Behar, Simon Claridge, Tom Jackson, Ben Sieniewicz, Bradley Porter, Jessica Webb, Ronak Rajani, Stamatis Kapetanakis, Gerald Carr-White, Christopher A Rinaldi
Cardiac resynchronization therapy (CRT) is an effective pacemaker delivered treatment for selected patients with heart failure with the target of restoring electro-mechanical synchrony. Imaging techniques using echocardiography have as yet failed to find a metric of dyssynchrony to predict CRT response. Current guidelines are thus unchanged in recommending prolonged QRS duration, severe systolic function and refractory heart failure symptoms as criteria for CRT implantation. Evolving strain imaging techniques in 3D echocardiography, cardiac MRI and CT may however, overcome limitations of older methods and yield more powerful CRT response predictors...
November 7, 2016: Expert Review of Cardiovascular Therapy
https://www.readbyqxmd.com/read/27960566/a-breakthrough-in-spontaneous-coronary-artery-dissection-pathogenesis-is-it-an-inherited-condition
#11
Siddak S Kanwar, Sharonne N Hayes, Timothy M Olson, Rajiv Gulati
No abstract text is available yet for this article.
January 2017: Expert Review of Cardiovascular Therapy
https://www.readbyqxmd.com/read/27935738/the-coronary-sinus-reducer-clinical-evidence-and-technical-aspects
#12
Francesco Giannini, Andrea Aurelio, Richard J Jabbour, Luca Ferri, Antonio Colombo, Azeem Latib
Chronic refractory angina is often a disabling condition, predominantly due to severe obstructive coronary artery disease, that is inadequately controlled by optimal medical therapy and not amenable to further percutaneous or surgical revascularization. mortality rates associated with this condition are relatively low in clinically stable patients. however, it is associated with a high hospitalization rate and a reduction in both exercise capacity and quality of life. due to the paucity of available treatment options, there is an unmet need for new therapies for these patients and for a reduction in the associated economic healthcare burden...
January 2017: Expert Review of Cardiovascular Therapy
https://www.readbyqxmd.com/read/27918214/immunosuppression-and-adult-heart-transplantation-emerging-therapies-and-opportunities
#13
Nicholas Furiasse, Jon A Kobashigawa
Immunosuppression following heart transplantation has improved graft longevity through the reduction of cellular and antibody mediated rejection. The attempt to limit the unintended consequences of immunosuppressive therapies and address sensitized patients has led to a revolution in immunosuppression. Areas covered: This review will focus on the current emerging immunosuppressive therapies in heart transplantation while reviewing the effective contemporary treatments, and explore the potential development of new immunomodulatory therapies...
January 2017: Expert Review of Cardiovascular Therapy
https://www.readbyqxmd.com/read/27905211/minimally-invasive-mitral-repair-surgery-why-does-controversy-still-persist
#14
Jeevan Nagendran, Jorge Catrip, Katie L Losenno, Corey Adams, Bob Kiaii, Michael W A Chu
Surgical treatment for mitral valve disease has evolved and remains a rapidly expanding field. Minimally invasive mitral valve repair (MI-MVR) is a well-known alternative to conventional sternotomy mitral valve repair (cMVR). However, controversy as to the efficacy of MI-MVR persists, hindering the adoption and potential benefits of this less invasive approach. Areas covered: In this review, we provide an updated summary evaluation of the latest evidence, including observational studies, clinical trials and meta-analyses, regarding MI-MVR in comparison to cMVR...
January 2017: Expert Review of Cardiovascular Therapy
https://www.readbyqxmd.com/read/27892770/myocardial-infarction-with-non-obstructive-coronary-arteries-minoca-a-whole-new-ball-game
#15
Nana Poku, Stephane Noble
MINOCA is a clinical syndrome that encompasses a subgroup of heterogeneous patients who present with myocardial infarction yet do not have any significant coronary artery obstruction on angiogram. As many as one in ten patients with acute myocardial infarction (AMI) will not have an occluded coronary artery, and the reported prevalence keeps rising, in part due to better recognition of this syndrome. Current guidelines offer several diagnostic algorithms but MINOCA remains largely under-recognised and little is known about whether patients might benefit from a more specific treatment modality...
January 2017: Expert Review of Cardiovascular Therapy
https://www.readbyqxmd.com/read/27892731/is-arachidonic-acid-stimulation-really-a-test-for-the-response-to-aspirin-time-to-think-again
#16
Bartosz Olechowski, Alexander Ashby, Mark Mariathas, Vikram Khanna, Michael Mahmoudi, Nick Curzen
Platelets play a key role in pathogenesis of atherothrombosis. Activated platelets initiate thrombus formation. Antiplatelet therapy (APT) modifies these properties. APT involves aspirin. The existence of 'aspirin resistance' is reported in many populations with cardiovascular disease. The prevalence of this phenomenon is highly variable, affecting more than 50% of patient subgroups in some papers. Areas covered: This review describes the prevalence of 'aspirin resistance', analyses why there is so much apparent variation and addresses whether the commonly used tests of aspirin response are in fact accurately assessing its functional performance...
January 2017: Expert Review of Cardiovascular Therapy
https://www.readbyqxmd.com/read/27858465/established-and-novel-treatment-options-in-acute-myocarditis-with-or-without-heart-failure
#17
George Lazaros, Evangelos Oikonomou, Dimitris Tousoulis
Acute myocarditis is a disorder characterized by an unpredictable clinical course which ranges from asymptomatic, incidentally discovered forms, to cases with fulminant course and adverse outcome. The most challenging issues in the context of acute myocarditis are the appearance of difficult to treat heart failure in the acute phase and the potential progression in the long-term to dilated cardiomyopathy. Areas covered: With respect to available treatment options in acute myocarditis, in the absence of specific guidelines, management is supportive and overall empirical, especially for the oligo- or asymptomatic patients with preserved ejection fraction...
January 2017: Expert Review of Cardiovascular Therapy
https://www.readbyqxmd.com/read/27801604/noncompaction-cardiomyopathy-and-stem-cell-therapy-from-pathogenesis-to-targeted-therapy
#18
Ozcan Ozeke, Dursun Aras, Omac Tufekcioglu, Sinan Aydogdu
No abstract text is available yet for this article.
January 2017: Expert Review of Cardiovascular Therapy
https://www.readbyqxmd.com/read/27801597/stem-or-progenitor-cells-for-treating-noncompaction
#19
Josef Finsterer, Claudia Stöllberger
No abstract text is available yet for this article.
January 2017: Expert Review of Cardiovascular Therapy
https://www.readbyqxmd.com/read/27817220/ectopic-fat-a-target-for-cardiometabolic-risk-management
#20
Amalia Gastaldelli, Melania Gaggini
No abstract text is available yet for this article.
December 2016: Expert Review of Cardiovascular Therapy
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