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Expert Review of Cardiovascular Therapy

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https://www.readbyqxmd.com/read/28618840/cardiac-surgery-in-solid-organ-transplant-recipients-a-clinical-challenge
#1
Mina Farag, Marina Nikolic, Alexander Weymann
Due to continuous improvement of transplant medicine, the number of solid organ transplant recipients in need of cardiac surgery is constantly growing. The objective of this work was to compare different reports on outcomes in patients with previous solid organ transplant after cardiac surgery. Areas covered: Published studies containing data about solid organ transplant recipients: renal, hepatic, pancreas or combined were identified through med-line research. Reported outcomes were categorized according to short- and long term-follow up and the presence or absence of a match-group...
June 16, 2017: Expert Review of Cardiovascular Therapy
https://www.readbyqxmd.com/read/28591518/intra-operative-mapping-of-the-atria-the-first-step-towards-individualization-of-atrial-fibrillation-therapy
#2
Charles Kik, Elisabeth M J P Mouws, Ad J J C Bogers, Natasja M S de Groot
Atrial fibrillation (AF), an age-related progressive disease, is becoming a worldwide epidemic with a prevalence rate of 33 million. Areas covered: In this expert review, an overview of important results obtained from previous intra-operative mapping studies is provided. In addition, our novel intra-operative high resolution mapping studies, its surgical considerations and data analyses are discussed. Furthermore, the importance of high resolution mapping studies of both sinus rhythm and AF for the development of future AF therapy is underlined by our most recent results...
June 15, 2017: Expert Review of Cardiovascular Therapy
https://www.readbyqxmd.com/read/28475386/achieving-blood-pressure-targets-for-prolonged-cardiovascular-health-a-historical-perspective
#3
Steven G Chrysant
Hypertension is a major risk factor for coronary artery disease (CAD), stroke, heart failure, and chronic kidney disease (CKD), and its successful control leads to a decrease or prevention of these complications. Areas covered: Over the years the Joint National Committees and the American Heart Association have issued guidelines regarding the treatment of hypertension. Those of 2003 and 2007 respectively, have recommended reduction of blood pressure (BP) to < 140/90 mmHg for uncomplicated hypertension and to < 130/80 mmHg for hypertensive patients with diabetes mellitus, CKD, or CAD...
May 15, 2017: Expert Review of Cardiovascular Therapy
https://www.readbyqxmd.com/read/28388241/chagas-disease-immunogenetics-elusive-markers-of-disease-progression
#4
Yelenca Ortega Zamora, Leidy Johana Escamilla Rojas, Elvis Mayron Villa Sandoval, Joan Steven Vela Porras, Edgar Yarleison Cossio Contrera, Sergio Sebastian Cubides Romero, Pedro David Carreño Ramirez, Hermes Urriago Losada, Carolina De Los Rios, Daniela Alejandra Gomez Mahecha, Karen Daniela Lovera Serrano, Juan Carlos Barreto Montaña, Viviana Lorena Narvaez Caicedo, Fredy Rs Gutierrez
Chagas disease (CD) is caused by a parasitic infection. The disease usually occurs after decades of the primary infection and can involve the myocardium or the digestive system. Of note, around 30% of T. cruzi infected patients develop CD while the other 70% may remain asymptomatic for their entire life. CD is usually observed as familial clustered phenomena. Moreover, individuals with chronic Chagas heart disease (CCHD) usually present a strong, deregulated immune response, which strongly suggests an immunogenetic effect...
April 7, 2017: Expert Review of Cardiovascular Therapy
https://www.readbyqxmd.com/read/28571513/a-pulmonary-embolism-response-team-initial-experiences-and-future-directions
#5
Emily K Zern, Michael N Young, Kenneth Rosenfield, Christopher Kabrhel
Acute pulmonary embolism (PE) is a common cardiovascular condition resulting in significant morbidity and mortality. Consensus recommendations suggest risk stratification of patients into three main categories: high-risk or 'massive' PE, intermediate-risk or 'submassive' PE, and low-risk PE. Given the relative dearth of prospective, randomized clinical trials delineating optimal selection of the diverse medical, interventional, and surgical treatment approaches, clinical care requires a multidisciplinary expert approach to patients with PE...
June 2017: Expert Review of Cardiovascular Therapy
https://www.readbyqxmd.com/read/28532237/catheter-ablation-as-first-line-in-atrial-fibrillation-is-rhythm-control-finally-better-than-rate-control
#6
Rhanderson Cardoso, André d'Avila
No abstract text is available yet for this article.
June 2017: Expert Review of Cardiovascular Therapy
https://www.readbyqxmd.com/read/28532180/premature-atrial-complexes-in-an-ischemic-stroke-population-and-risk-of-recurrent-stroke-a-systematic-review
#7
Michala Herskind Sejr, Sam Riahi, Torben Bjerregaard Larsen, Jens Cosedis Nielsen, Peter Brønnum Nielsen
Premature atrial complexes (PACs) have been proposed as a possible mediator between normal sinus rhythm and atrial fibrillation (AF). The aim of this study was to summarize the available knowledge of association between PACs and recurrent stroke or transient ischemic attack (TIA) in ischemic stroke patients. Areas covered: In this systematic review, we investigated the risk of recurrent events in patients who experienced ischemic stroke or TIA. Occurrence of PACs in electrocardiographic monitoring after index stroke/TIA was required...
June 2017: Expert Review of Cardiovascular Therapy
https://www.readbyqxmd.com/read/28514878/anticoagulant-cessation-following-atrial-fibrillation-ablation-limits-of-the-ecg-guided-approach
#8
Matteo Anselmino, Chiara Rovera, Giovanni Marchetto, Federico Ferraris, Davide Castagno, Fiorenzo Gaita
Long-term cessation of oral anticoagulation (OAC) following successful catheter or surgical ablation of atrial fibrillation (AF) is debated. Usually, in the presence of sinus rhythm at serial ECG recordings, the CHADS2, CHA2DS2VASc, and HAS-BLED scores are adopted to guide decision regarding OAC management. Areas covered: The safety of OAC cessation in patients without recurrent AF but with historically elevated risk for thromboembolism remains largely unknown. Taking the cue from two clinical cases, we provide an updated summary of the latest evidence regarding how to manage OAC after a successful atrial fibrillation ablation...
June 2017: Expert Review of Cardiovascular Therapy
https://www.readbyqxmd.com/read/28489502/advances-in-cardiac-pacing-and-defibrillation
#9
Kristin Ellison, Parikshit S Sharma, Richard Trohman
There have been many evolutionary milestones in cardiac implantable electronic device (CIED) therapy over the past few decades. These advancements have created new  challenges. Right ventricular pacing was the original (late 1950s) breakthrough, however the risk of pacing induced dyssynchrony has become evident. Biventricular pacing provided a viable way to mitigate dyssynchrony, but only benefits certain patients (primarily left bundle branch block and QRS duration ≥150 ms with depressed left ventricular (LV) function)...
June 2017: Expert Review of Cardiovascular Therapy
https://www.readbyqxmd.com/read/28475383/fractional-flow-reserve-in-2017-current-data-and-everyday-practice
#10
J J Coughlan, Colin MacDonnell, Samer Arnous, Thomas J Kiernan
Fractional flow reserve (FFR) is an objective physiological index utilized in coronary angiography. It expresses the blood flow in the presence of a coronary artery stenosis as a fraction of the normal blood flow and gives information regarding the functional significance of the lesion. FFR guided percutaneous coronary intervention (PCI) has been shown to be superior to angiography guided PCI in several trials and registries. In addition, it appears that the use of FFR may also be preferable from an economic perspective...
June 2017: Expert Review of Cardiovascular Therapy
https://www.readbyqxmd.com/read/28471277/ongoing-and-future-directions-in-percutaneous-treatment-of-mitral-regurgitation
#11
Shingo Kuwata, Maurizio Taramasso, Andrea Guidotti, Fabian Nietlispach, Francesco Maisano
Mitral regurgitation (MR) is one of the major valvular disease. Although surgical mitral valve (MV) repair is the standard of care for patients with severe MR, an unmet need exists in the management of patients with severe symptomatic MR and high surgical risk. Transcatheter MV therapies are alternative treatment option in such patients with moderate to severe and symptomatic MR. Areas covered: Literatures to direct the reader to important further reading were searched with relevant websites; www.ncbi.nlm.nih...
June 2017: Expert Review of Cardiovascular Therapy
https://www.readbyqxmd.com/read/28425765/the-prevention-and-treatment-of-venous-thromboembolism-in-pregnancy
#12
Michela Villani, Walter Ageno, Elvira Grandone, Francesco Dentali
Venous thromboembolism (VTE) in pregnancy represents an important cause of maternal morbidity and mortality in developed countries, with an incidence of 0.5-2.2 per 1000 pregnancies. In addition to hemostatic changes occurring during normal pregnancy, several risk factors have been identified. Thus, a variety of clinical conditions as well as fetal and maternal risks linked to a possible anticoagulant therapy should be considered for the management of VTE during pregnancy. Unfortunately, there is a paucity of high-quality evidence from randomized trials in this field, and current recommendations are based on observational studies or evidence gathered from studies in the non-pregnant population...
May 2017: Expert Review of Cardiovascular Therapy
https://www.readbyqxmd.com/read/28406333/eat-breathe-ros-controlling-stem-cell-fate-through-metabolism
#13
Dieter A Kubli, Mark A Sussman
Research reveals cardiac regeneration exists at levels previously deemed unattainable. Clinical trials using stem cells demonstrate promising cardiomyogenic and regenerative potential but insufficient contractile recovery. Incomplete understanding of the biology of administered cells likely contributes to inconsistent patient outcomes. Metabolism is a core component of many well-characterized stem cell types, and metabolic changes fundamentally alter stem cell fate from self-renewal to lineage commitment, and vice versa...
May 2017: Expert Review of Cardiovascular Therapy
https://www.readbyqxmd.com/read/28395557/using-personalized-computer-models-to-custom-tailor-ablation-procedures-for-atrial-fibrillation-patients-are-we-there-yet
#14
Patrick M Boyle, Sohail Zahid, Natalia A Trayanova
No abstract text is available yet for this article.
May 2017: Expert Review of Cardiovascular Therapy
https://www.readbyqxmd.com/read/28395556/this-patient-is-not-breathing-properly-is-this-copd-heart-failure-or-neither
#15
Pierpaolo Pellicori, Damien Salekin, Daniel Pan, Andrew L Clark
Heart failure (HF) and chronic obstructive pulmonary disease (COPD) are two common, heterogeneous, long-term illnesses which cause significant morbidity and mortality. Although they both present with breathlessness, they are treated differently. Treatment of COPD focuses mainly on relieving short-term breathlessness, whilst treatment of HF has focused on long term morbidity and mortality. Areas covered: In this review, we aim to highlight the diagnostic challenges in distinguishing COPD from HF. We also explore the implications of their overlap, and the use of biomarkers and treatments for HF in patients with COPD to improve long-term outcomes...
May 2017: Expert Review of Cardiovascular Therapy
https://www.readbyqxmd.com/read/28351172/current-status-of-mechanical-circulatory-support-for-treatment-of-advanced-end-stage-heart-failure-successes-shortcomings-and-needs
#16
Gengo Sunagawa, Marijan Koprivanac, Jamshid H Karimov, Nader Moazami, Kiyotaka Fukamachi
Heart failure (HF) remains a major global burden in terms of morbidity and mortality. Despite advances in pharmacological and resynchronization device therapy, many patients worsen to end-stage HF. Although the gold-standard treatment for such patients is heart transplantation, there will always be a shortage of donor hearts. Areas covered: A left ventricular assist device (LVAD) is a valuable option for these patients as a bridge measure (to recovery, to candidacy for transplant, or to transplant itself) or as destination therapy...
May 2017: Expert Review of Cardiovascular Therapy
https://www.readbyqxmd.com/read/28349717/hdl-and-macrophages-explaining-the-clinical-failures-and-advancing-hdl-based-therapeutics-in-cardiovascular-diseases
#17
Emiel P C van der Vorst, Kosta Theodorou, Erik A L Biessen, Marjo M P C Donners
No abstract text is available yet for this article.
May 2017: Expert Review of Cardiovascular Therapy
https://www.readbyqxmd.com/read/28338353/the-burden-of-familial-chylomicronemia-syndrome-interim-results-from-the-in-focus-study
#18
Michael Davidson, Michael Stevenson, Andrew Hsieh, Zahid Ahmad, Caroline Crowson, Joseph L Witztum
BACKGROUND: Familial Chylomicronemia Syndrome (FCS) is a rare genetic disorder that is caused by a decrease or an absence of lipoprotein lipase activity. FCS is characterized by marked accumulation of chylomicrons and extreme hypertriglyceridemia, which have major effects on both physical and mental health. To date, there have been no systematic efforts to characterize the impact of chylomicronemia on FCS patients' lives. In particular, the impact of FCS on the burden of illness (BoI) and quality of life (QoL) has not been fully described in the literature...
May 2017: Expert Review of Cardiovascular Therapy
https://www.readbyqxmd.com/read/28319424/rivaroxaban-in-patients-with-atrial-fibrillation-from-rocket-af-to-everyday-practice
#19
Gonzalo Barón-Esquivias, Francisco Marín, Marcelo Sanmartín Fernandez
Registries and non-interventional studies offer relevant and complementary information to clinical trials, since they have a high external validity. Areas covered: The information regarding the efficacy and safety of rivaroxaban compared with warfarin, or rivaroxaban alone in clinical practice was reviewed in this manuscript. For this purpose, a search on MEDLINE and EMBASE databases was performed. The MEDLINE and EMBASE search included both medical subject headings (MeSH) and keywords including: atrial fibrillation (AF) OR warfarin OR clinical practice OR ROCKET AF AND rivaroxaban...
May 2017: Expert Review of Cardiovascular Therapy
https://www.readbyqxmd.com/read/28271724/adjuncts-to-transcatheter-aortic-valve-implantation
#20
Hzr McConkey, S S Arri, J P Joseph, B D Prendergast, S Redwood
The appreciable rise in percutaneous valve procedures has been pursued by a wave of development in advanced technology to help guide straightforward, streamlined and safe intervention. This review article aims to highlight the adjunctive devices, tools and techniques currently used in transcatheter aortic valve implantation procedures to avoid potential pitfalls. Areas covered: The software and devices featured here are at the forefront of technological advances, most of which are not yet in widespread use...
May 2017: Expert Review of Cardiovascular Therapy
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