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Expert Review of Cardiovascular Therapy

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https://www.readbyqxmd.com/read/29164945/cardiovascular-complications-of-multiple-myeloma-in-the-elderly
#1
Pankaj Mathur, Sharmilan Thanendrarajan, Hakan Paydak, Srikanth Vallurupalli, Kedar Jambhekar, Sabha Bhatti, Carolina D Schinke, Faith E Davies, Jawahar L Mehta
Multiple myeloma is a malignant neoplasm characterized by plasma cell proliferation in blood and bone marrow. Approximately two-thirds of the patients with multiple myeloma are >65 years at the time of diagnosis. Patients in this age group often have co-existing cardiovascular diseases. Areas covered: The presence of multiple myeloma adds to the malady by direct deposition of amyloid protein in the heart or via toxicity of chemotherapeutic agents. Cardiac contractile dysfunction, arrhythmias and thromboembolic disorders are the main issues in the management of elderly patients with multiple myeloma...
November 22, 2017: Expert Review of Cardiovascular Therapy
https://www.readbyqxmd.com/read/29164942/why-cardiologists-should-be-on-social-media-the-value-of-online-engagement
#2
M Chadi Alraies, Sheila Sahni
No abstract text is available yet for this article.
November 22, 2017: Expert Review of Cardiovascular Therapy
https://www.readbyqxmd.com/read/29161923/recognizing-and-reacting-to-complications-of-trans-septal-puncture
#3
Francesca Salghetti, Juan Sieira, Gian-Battista Chierchia, Antonio Curnis, Carlo de Asmundis
The transseptal puncture (TSP) enables access to the left heart, through the fossa ovalis (FO), both in electrophysiology and in cardiac interventional procedures. TSP is usually safe in experienced hands. Sometimes TSP can be technically demanding and carries the risk of severe complications in approximately 1%. While performing a TSP, every effort should be taken in order to avoid complications. In the event of complications, prompt recognition and reaction are essential and a combined "heart-team" management may be the most effective approach...
November 22, 2017: Expert Review of Cardiovascular Therapy
https://www.readbyqxmd.com/read/29157029/corrigendum
#4
(no author information available yet)
No abstract text is available yet for this article.
November 20, 2017: Expert Review of Cardiovascular Therapy
https://www.readbyqxmd.com/read/29157024/critical-limb-ischemia-update-and-the-evolving-role-of-drug-elution-technologies
#5
Jared B Hooker, Beau M Hawkins
Critical limb ischemia (CLI) is a prevalent condition associated with cardiovascular mortality and limb loss. Areas Covered: This review discusses the epidemiology of CLI, revascularization options, and drug-elution therapies. Expert commentary: Drug-eluting stents (DES) and drug-coated balloons (DCB) improve patency rates in the femoropopliteal segment, and are generally used as first-line therapies. For below-knee disease, angioplasty is the default strategy unless lesions are focal whereby DES can be used to reduce restenosis risk...
November 20, 2017: Expert Review of Cardiovascular Therapy
https://www.readbyqxmd.com/read/29034751/less-than-two-versus-greater-than-two-hour-invasive-strategy-in-non-st-elevation-myocardial-infarction-a-meta-analysis-of-randomized-controlled-trials
#6
Poonam Velagapudi, Mohit Turagam, Dhaval Kholte, Sahil Khera, Parag Parikh, Omar Hyder, Herbert Aronow, Dawn Abbott
BACKGROUND: Optimal timing for an invasive strategy in non-ST elevation myocardial infarction (NSTEMI) is unclear. Whether clinical outcomes are improved with a less than two (LT2) compared with greater than two hour (GT2) invasive strategy remains to be determined. We performed a meta-analysis of randomized controlled trials (RCTs) comparing LT2 vs GT2 for NSTEMI. METHODS: A comprehensive literature search for RCTs comparing LT2 vs. GT2 in NSTEMI patients was performed...
October 19, 2017: Expert Review of Cardiovascular Therapy
https://www.readbyqxmd.com/read/28949265/reference-values-for-blood-pressure-response-to-cycle-ergometry-in-the-first-two-decades-of-life-comparison-with-patients-with-a-repaired-coarctation-of-the-aorta
#7
Mirna Kaafarani, Christian Schroer, Tim Takken
BACKGROUND: It is now common practice to use hemodynamic responses to exercise as markers of diagnosis for cardiac diseases in children, systolic blood pressure especially. However, the reference values for SBP in children at peak exertion level are outdated, and, without a current definition of normal, clinicians cannot determine the physiologically impaired. OBJECTIVE: This study aimed to establish current reference values for peak systolic blood pressure (SBP), rate pressure product (RPP), and circulatory power (CircP)...
September 26, 2017: Expert Review of Cardiovascular Therapy
https://www.readbyqxmd.com/read/28846060/in-vivo-visualization-of-lipid-coronary-atheroma-with-intravascular-near-infrared-spectroscopy
#8
Yu Kataoka, Rishi Puri, Jordan Andrews, Satoshi Honda, Kensaku Nishihira, Yasuhide Asaumi, Teruo Noguchi, Satoshi Yasuda, Stephen J Nicholls
Atherosclerotic cardiovascular disease (ASCVD) has become a major health burden and is expected to further increase in the future. Better predictive approaches for ASCVD and more efficacious therapies are required to further improve cardiovascular outcomes. Intravascular imaging has contributed to the elucidation of atherosclerotic mechanisms and evaluation of novel therapies. Near-infrared spectroscopy has enabled the visualization of the lipid extent of atherosclerotic plaques in vivo. Given that lipid accumulation is considered to promote the formation and progression of atherosclerosis, this technology may harbor the potential to identify subjects with high cardiovascular risks and thus adopt more optimized therapeutic approaches...
August 28, 2017: Expert Review of Cardiovascular Therapy
https://www.readbyqxmd.com/read/28990450/revisiting-the-role-of-durable-polymers-in-cardiovascular-devices
#9
Hiroyoshi Mori, Fumiyuki Otsuka, Anuj Gupta, Hiroyuki Jinnouchi, Sho Torii, Emanuel Harari, Renu Virmani, Aloke V Finn
Polymers are an essential component of drug-eluting stents (DES) used to control drug release but remain the most controversial component of DES technology. There are two types of polymers employed in DES: durable polymer based DES (DP-DES) and biodegradable polymer DES (BP-DES). First-generation DES were exclusively composed of DP and demonstrated increased rates of late stent failure due in part to poor polymer biocompatibility. Newer generations DES use more biocompatible durable polymers or biodegradable polymers...
November 2017: Expert Review of Cardiovascular Therapy
https://www.readbyqxmd.com/read/28914558/robotics-in-percutaneous-cardiovascular-interventions
#10
Ali Pourdjabbar, Lawrence Ang, Omid Behnamfar, Mitul P Patel, Ryan R Reeves, Paul T Campbell, Ryan D Madder, Ehtisham Mahmud
The fundamental technique of performing percutaneous cardiovascular (CV) interventions has remained unchanged and requires operators to wear heavy lead aprons to minimize exposure to ionizing radiation. Robotic technology is now being utilized in interventional cardiology partially as a direct result of the increasing appreciation of the long-term occupational hazards of the field. This review was undertaken to report the clinical outcomes of percutaneous robotic coronary and peripheral vascular interventions...
November 2017: Expert Review of Cardiovascular Therapy
https://www.readbyqxmd.com/read/28914109/stem-cell-therapy-for-the-systemic-right-ventricle
#11
Ming-Sing Si, Richard G Ohye
In specific forms of congenital heart defects and pulmonary hypertension, the right ventricle (RV) is exposed to systemic levels of pressure overload. The RV is prone to failure in these patients because of its vulnerability to chronic pressure overload. As patients with a systemic RV reach adulthood, an emerging epidemic of RV failure has become evident. Medical therapies proven for LV failure are ineffective in treating RV failure. Areas covered: In this review, the pathophysiology of the failing RV under pressure overload is discussed, with specific emphasis on the pivotal roles of angiogenesis and oxidative stress...
November 2017: Expert Review of Cardiovascular Therapy
https://www.readbyqxmd.com/read/28902523/functional-assessment-of-lesion-severity-without-using-the-pressure-wire-coronary-imaging-and-blood-flow-simulation
#12
Michail I Papafaklis, Michail C Mavrogiannis, Panagiotis K Siogkas, Lampros S Lakkas, Christos S Katsouras, Dimitrios I Fotiadis, Lampros K Michalis
Hemodynamic indices derived from measurements with the pressure wire (primarily fractional flow reserve [FFR]) have been established as a reliable tool for assessing coronary stenoses and improving clinical decision making. However, the use of the pressure wire constitutes a hurdle for the universal adoption of physiology-guided patient management. Technological advancements have enabled the large-scale application of blood flow simulation (computational fluid dynamics [CFD]) to medical imaging, thereby enabling the virtual assessment of coronary physiology...
November 2017: Expert Review of Cardiovascular Therapy
https://www.readbyqxmd.com/read/28893096/assessing-genetic-risk-of-hypertension-at-an-early-age-future-research-directions
#13
Xiaoling Wang, Harold Snieder
No abstract text is available yet for this article.
November 2017: Expert Review of Cardiovascular Therapy
https://www.readbyqxmd.com/read/28885062/out-of-hospital-cardiac-arrest-always-coronary-angiography
#14
Andrea Rognoni, Chiara Cavallino, Marco Giovanni Mennuni, Lucia Barbieri, Roberta Rosso, Francesco Rametta, Federico Nardi, Alessandro Lupi, Angelo Sante Bongo
Out-of-hospital cardiac arrest (OHCA) remains one of the principle challenges in the setting of critical care medicine and emergency cardiology. Areas covered: Long-term survival rates even after successful resuscitation are variable but increasing in the recent years; due to the improvement of base and advanced cardiac life support techniques an increasing number of resuscitated patients are admitted to the hospital. Recent data suggested that patients surviving to hospital discharge after OHCA presented long-term outcome similar to patients with ST-elevation myocardial infarction...
November 2017: Expert Review of Cardiovascular Therapy
https://www.readbyqxmd.com/read/28875729/role-of-cardiac-pacing-in-congenital-complete-heart-block
#15
Stephanie F Chandler, Francis Fynn-Thompson, Douglas Y Mah
Congenital complete heart block affects 1/15,000 live-born infants, predominantly due to atrioventricular nodal injury from maternal antibodies of mothers with systemic lupus erythermatosus or Sjogren's syndrome. The majority of these children will need a pacemaker implanted prior to becoming young adults. This article will review the various patient and technical factors that influence the type of pacemaker implanted, and the current literature on optimal pacing practices. Areas covered: A literature search was performed using PubMed, Embase and Web of Science...
November 2017: Expert Review of Cardiovascular Therapy
https://www.readbyqxmd.com/read/28847199/the-burden-of-familial-chylomicronemia-syndrome-from-the-patients-perspective
#16
Andres Gelrud, Karren R Williams, Andrew Hsieh, Andrea R Gwosdow, Alan Gilstrap, Alan Brown
BACKGROUND: Familial chylomicronemia syndrome (FCS) is a rare, inherited lipid disorder characterized by high levels of plasma triglycerides and chylomicrons, which may cause life-threatening acute pancreatitis. Currently no FDA-approved treatment exists. Management is low-fat diet (<20g fat/day), which is difficult to maintain. With the restricted diet, triglycerides may remain elevated. We conducted discussions with patients and caregivers to better understand the burden of FCS from their perspectives...
November 2017: Expert Review of Cardiovascular Therapy
https://www.readbyqxmd.com/read/28830266/using-biomarkers-to-guide-heart-failure-management
#17
Kay-Won Chang, Sutton Fox, Sean Mojaver, Alan S Maisel
Biomarkers have revolutionized the diagnosis of heart failure (HF), but it remains unclear how to use biomarkers to guide management of HF. Areas covered: An exhaustive literature search on using biomarkers to guide HF management was performed. HF guidelines were carefully scrutinized for references pertaining to this topic, and Medline was employed to identify further references. This review focused on natriuretic peptides, troponin, and ST2 as biomarkers used to guide HF management. Most trials have examined secondary prevention of chronic HF patients, and data on primary prevention of HF and therapy of acute HF are emerging...
October 2017: Expert Review of Cardiovascular Therapy
https://www.readbyqxmd.com/read/28792246/assessing-the-efficacy-of-endovascular-therapy-in-stroke-treatments-updates-from-the-new-generation-of-trials
#18
Gregory B Walker, Ashutosh P Jadhav, Tudor G Jovin
For the past 20 years, intravenous recombinant tissue plasminogen activator (rt-PA) has been the only proven treatment for acute ischemic stroke. Large arteries such as the internal carotid artery, the middle cerebral artery and the basilar artery supply blood to large volumes of brain tissue. When occluded, these vessels may have low response rates to rt-PA resulting in devastating injury and death. Areas covered: In 2013, three trials evaluating the efficacy of mechanical thrombectomy in acute stroke were neutral, however, lessons learned from these trials resulted in a second generation of five trials in 2015 and a sixth in 2016 which all demonstrated significant benefit for select patients...
October 2017: Expert Review of Cardiovascular Therapy
https://www.readbyqxmd.com/read/28792241/intracoronary-nitroglycerin-recognizing-coronary-spasm-first-and-foremost-to-avoid-unnecessary-coronary-stents
#19
Alec Vishnevsky, David L Fischman, Michael P Savage
No abstract text is available yet for this article.
October 2017: Expert Review of Cardiovascular Therapy
https://www.readbyqxmd.com/read/28764576/contemporary-evaluation-of-mitral-regurgitation-3d-echocardiography-cardiac-magnetic-resonance-and-procedural-planning
#20
Frank E Corrigan, Aneel Maini, Shawn Reginauld, Stamatios Lerakis
Mitral regurgitation is one of the more common forms of valvular heart disease. Given the expansion of therapies for structural heart disease, new therapies for mitral regurgitation are emerging. An accurate description and classification of mitral disease is important to understand pathology and provide recommendations for therapy. Areas covered: In the modern evaluation of mitral regurgitation, 3-dimensional echocardiography (3DE) and cardiac magnetic resonance imaging (CMR) play important roles which overcome the prior limitations of 2-dimensional echocardiography...
September 2017: Expert Review of Cardiovascular Therapy
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