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Therapeutic Apheresis and Dialysis

Taro Hoshino, Shohei Kaneko, Saori Minato, Katsunori Yanai, Yuko Mutsuyoshi, Hiroki Ishii, Taisuke Kitano, Mitsutoshi Shindo, Haruhisa Miyazawa, Akinori Aomatsu, Kiyonori Ito, Yuichiro Ueda, Keiji Hirai, Susumu Ookawara, Yoshiyuki Morishita
High concentrations of lactate are considered to contribute to impairment of the peritoneal membrane. We investigated the longer-period effects of bicarbonate/lactate-buffered neutral peritoneal dialysis fluid (PDF) in patients undergoing PD for about 2 years. Patients undergoing PD were changed from a lactate-buffered neutral PDF to a bicarbonate/lactate-buffered neutral PDF. We then investigated the patients' clinical outcomes and peritoneal membrane functions as well as the surrogate markers in the drained dialysate...
July 16, 2018: Therapeutic Apheresis and Dialysis
Akihito Tanaka, Daijo Inaguma, Yu Watanabe, Takahiro Mizukawa, Hibiki Shinjo, Kiyomi Koike, Yasuhiro Otsuka, Asami Takeda
The rate of hepatitis B infection among hemodialysis patients is high. However, it is not clear if this rate reflects the infection rate among patients with chronic kidney disease (CKD). Therefore, we evaluated the rate of hepatitis B infection among patients with CKD. This is an important clinical issue when considering the risk of infection to medical staff when performing invasive procedures in this clinical population. A retrospective, observational study was conducted among stable, non-dialysis patients with CKD who attended a CKD educational program at our hospital, between August 2012 and October 2017...
July 15, 2018: Therapeutic Apheresis and Dialysis
Mohamed Momtaz, Ahmed Fayed, Khaled Marzouk, Amr Shaker
Therapeutic plasma exchange is used in treating different immunological and non-immunological diseases. We analyzed the outcome of 308 patients treated by 1783 membrane plasma exchange sessions from January 2011 until January 2017 at Cairo University Hospital. Thrombotic microangiopathies were the commonest indication [73 (23.7%) patients] with response in 63/73 patients (86.3%), followed by systemic vasculitis with pulmonary-renal involvement [40(13%) patients] with recovery in 32/40 patients (80.0%), Guillain-Barré syndrome [39(12...
July 15, 2018: Therapeutic Apheresis and Dialysis
Nadia Saavedra-Fuentes, Héctor Pérez-Grovas, Ruth Navarrete, Claudia Lerma
The aim of this study was to evaluate the intraocular pressure during hemodialysis and hemodiafiltration. Fifteen patients were enrolled (seven treated with hemodialysis therapy and eight with hemodiafiltration). The intraocular pressure was measured before and after dialysis and every 30 min during dialysis. Before dialysis, both groups had similar dialysis prescription, blood pressure, and biochemical parameters. At the end of dialysis, potassium, and osmolarity decreased in both groups, while systolic blood pressure and sodium decreased in the hemodialysis group, and glucose decreased in the hemodiafiltration group...
July 15, 2018: Therapeutic Apheresis and Dialysis
Chieko Higuchi, Junko Kuriyma, Hiroshi Sakura
Conventional acidic icodextrin peritoneal dialysate (CI) has low biocompatibility due to its low pH, and a neutral pH icodextrin dialysate (NI) was developed. The influence of NI on the peritoneum has not been clarified. The effects of the two dialysates on cultured rat mesothelial cells were examined. CI, but not NI, increased α-smooth muscle actin, collagen type 1 and 3, and P21 mRNA expressions. CI with neutralized pH did not improve these harmful effects. With NI+ glucose degradation products (GDPs: same concentration as CI), mRNA expressions were comparable to those with NI alone...
July 15, 2018: Therapeutic Apheresis and Dialysis
Sanja Sakan, Vedran Premuzic, Daniela Bandic Pavlovic, Nikolina Basic-Jukic
The main goal of our study was to investigate the role of increased fibroblast growth factor 23 (FGF23) levels on renal recovery and overall survival. We conducted a prospective case-control cohort study, which included 121 adult cases who developed AKI after major surgical procedures. The subjects were followed-up until the last enrolled patient survived 180 days or until the time of death. Higher FGF23 levels positively correlated with serum creatinine levels (P < 0.05). Significantly higher number of patients without diuresis and with FGF23 ≤ 709 RU/mL survived when compared to patients without diuresis and with FGF23 ≥ 709 RU/mL (P < 0...
July 15, 2018: Therapeutic Apheresis and Dialysis
Ramona Nicotera, Giuseppe Leonardi, Alberto Castagna, Valeria Cernaro, Giuseppe Coppolino
No abstract text is available yet for this article.
July 15, 2018: Therapeutic Apheresis and Dialysis
Aaron Pariente, Jérémie Joffre, Olivier Fain, Paul Coppo, Arsène Mekinian
No abstract text is available yet for this article.
July 11, 2018: Therapeutic Apheresis and Dialysis
Valeria Cernaro, Giovanni Tripepi, Luca Visconti, Antonio Lacquaniti, Gaetano Montalto, Adolfo Romeo, Domenica Cimadoro, Giuseppe Costantino, Francesco Torre, Domenico Santoro, Michele Buemi
According to many studies, extracorporeal dialysis with convective methods is associated with better clinical outcomes and a survival benefit compared to diffusive techniques. However, there is no full agreement on the actual superiority of this kind of renal replacement therapy on hard end-points such as mortality. We performed a retrospective epidemiological cohort study to provide "real-world" evidence on the impact of convective and non-convective dialysis techniques on all-cause and cardiac mortality and biochemical outcomes among dialysis patients in Sicily, the southernmost region of Italy...
July 10, 2018: Therapeutic Apheresis and Dialysis
Cemal Kocaaslan, Muhammed B Ozturk, Mustafa Aldag, Mehmet S Bademci, Ahmet Öztekin, Ebuzer Aydin
No abstract text is available yet for this article.
July 10, 2018: Therapeutic Apheresis and Dialysis
Nobuo Nagano, Ayako Minegishi, Kyoko Ito, Tetsuo Ando, Takaaki Tsutsui, Tetsuya Ogawa
Most patients undergoing dialysis are required to take many phosphate binder pills to control hyperphosphatemia. Phosphate binders prescribed in Japan are classified into two types: metal-based binders (Ca carbonate, lanthanum carbonate, ferric citrate hydrate, and sucroferric oxyhydroxide) and chemically synthesized polymers (sevelamer hydrochloride and bixalomer). The raw materials of metal-based phosphate binders are natural ores; thus, such binders may contain several other metallic elements. We measured the elemental contents in six metal-based phosphate binders using an inductively coupled plasma mass - spectrometry (ICP-MS) method...
July 10, 2018: Therapeutic Apheresis and Dialysis
Yao-Min Hung, Yu-Yen Chen, Wei-Chun Huang, Paul Yung Pou Wang, Pesus Chou, Yun-Ju Lai
The hemodynamic effects of hemodialysis (HD) and peritoneal dialysis (PD) on end-stage renal disease (ESRD) patients differ. The influence of dialysis modalities on the cardiovascular system has not been well investigated. We aimed to evaluate the association between dialysis modalities and risk of coronary artery disease (CAD) by using the claim data of Taiwan's Longitudinal Health Insurance Database. This study followed up a cohort of 1624 new onset ESRD patients (≥18 years old), who had started renal replacement therapy during 2000 to 2010; and was followed until 2012...
July 10, 2018: Therapeutic Apheresis and Dialysis
Yongpeng Zhang, Liying Yan, Wang Han
Circulating microRNAs have the potential to be noninvasive biomarkers for assessing disease progression. MicroRNA-551b-5p (miR-551b-5p) was previously reported to be differentially expressed in pancreatic patients. The serum miR-551b-5p level was measured in patients with mild acute pancreatitis (MAP), severe acute pancreatitis (SAP), and healthy controls using quantitative real-time polymerase chain reaction (RT-PCR) analysis to evaluate its impact on inflammatory response. Acute Physiology and Chronic Health Evaluation II (APACHE II), Multiple Organ Dysfunction Score (MODS), Sequential Organ Assessment Score (SOFA), and Ranson's scores were recorded...
July 10, 2018: Therapeutic Apheresis and Dialysis
Motoki Urata, Yuki Narita, Masaki Fukunaga, Daisuke Kadowaki, Sumio Hirata
The present study sought to derive a simple formula for predicting the drug removal rates during hemodialysis. We examined the relationship between drug removal rates during hemodialysis and the molecular weights or pharmacokinetic parameters of injectable drugs (N = 90) obtained from pharmaceutical interview forms in Japan. Stepwise multiple regression analysis with the removal rate by hemodialysis as the objective variable adjusted for molecular weight or pharmacokinetic parameters as explanatory variables, showed that the logarithm of molecular weight (B = -18...
July 10, 2018: Therapeutic Apheresis and Dialysis
Tomoko Honda, Satoru Kishi, Emi Furukawa, Hiroko Ambe, Yu Kurata, Masahiro Ichikawa, Mari Aoe, Ken Ohara, Satoshi Furuse, Katsunori Saito, Kyosuke Nishio, Kazunobu Masaki, Tatsuya Kano, Naobumi Mise
Eicosapentaenoic acid (EPA)/arachidonic acid (AA) ratio showed inverse associations with cardiovascular disease (CVD) in general population. However, this has not been examined enough in dialysis patients. We cross-sectionally investigated the relationship between EPA/AA ratio and prevalence of CVD in 321 chronic hemodialysis patients (64 ± 11 years old; 110 women; dialysis vintage 10 ± 8 years) in an urban area of Tokyo. CVD was defined as a composite of ischemic heart disease, ischemic stroke and hemorrhagic stroke...
July 10, 2018: Therapeutic Apheresis and Dialysis
Maurizio Bossola, Enrico Di Stasio, Vittorio Sirolli, Fabio Ippoliti, Stefano Cenerelli, Tania Monteburini, Emanuele Parodi, Stefano Santarelli, Pier Eugenio Nebiolo, Mario Bonomini, Anna Picca, Riccardo Calvani, Emanuele Marzetti
The aim of the present study was to determine the intensity, duration, frequency and prevalence of postdialysis fatigue (PDF) in patients on chronic hemodialysis (PCD) with and without functional disability. Patients underwent assessment of functional ability by the Katz ADL (activity daily living) questionnaire and the Lawton and Brody scale for the instrumental activity daily living (IADL) fatigue using the SF-36 Vitality Subscale, comorbidity through the Charlson comorbidity score index (CDI), and time of recovery after hemodialysis (TIRD)...
July 4, 2018: Therapeutic Apheresis and Dialysis
Marcin Krzanowski, Katarzyna Krzanowska, Paulina Dumnicka, Mariusz Gajda, Karolina Woziwodzka, Danuta Fedak, Tomasz Grodzicki, Jan A Litwin, Władysław Sułowicz
We studied the correlations between circulating osteoprotegerin (OPG) level and radial artery calcification (RAC) assessed histologically and carotid artery intima-media thickness (CCA-IMT). Moreover, we studied the relationship between OPG levels and all-cause and cardiovascular (CV) mortality during a 5-year observation period. The study comprised 59 CKD patients (36 hemodialyzed (HD), 23 predialysis). The biochemical parameters included: creatinine, calcium, phosphate, intact parathormone, C-reactive protein, interleukin-6, tumor necrosis factor receptor II (TNFRII), transforming growth factor-β, hepatocyte growth factor, fibroblast growth factor 23, osteonectin (ON), osteopontin, osteoprotegerin, and osteocalcin...
July 4, 2018: Therapeutic Apheresis and Dialysis
Peter Ryan, Lauren Le Mesurier, Kelly Adams, Peter Choi, Bobby Chacko
Long-term hemodialysis (HD) imposes a significant burden on the quality of life of end-stage kidney disease patients. Optimizing dialysis dose is an important consideration in this population; however, evidence exists that suggests that attainment of population dialysis targets is associated with increased intradialytic complications. In this prospective, before-after study, the blood flow rate (BFR) of 63 maintenance HD patients was increased by 100 mL/min to a maximum BFR of 400 mL/min to determine the impact on patient tolerability and urea reduction ratio (URR) of an increased BFR...
July 4, 2018: Therapeutic Apheresis and Dialysis
Salehoddin Bouya, Abbas Balouchi, Hosein Rafiemanesh, Mehran Hesaraki
The aim of this study was to determine the prevalence of CKD in the Iranian general population. In this systematic review and meta-analysis study, international (PubMed, Web of Science, Scopus, and Google scholar) and national databases (SID, Magiran) were searched until December 30, 2017. The quality of the studies was evaluated using the Hoy instrument. Out of 1170 initial studies, 9 studies with a total of 70 605 participants were included in the final stage of this study. Based on the results of the random effect method (95% CI), the overall prevalence of chronic kidney disease in 70 605 people was 15...
July 4, 2018: Therapeutic Apheresis and Dialysis
Shota Suzuki, Midori Shino, Tetsuya Fujikawa, Yoko Itoh, Eiko Ueda, Tatsuo Hashimoto, Tadashi Kuji, Naoyuki Kobayashi, Toshimasa Ohnishi, Nobuhito Hirawa, Kouichi Tamura, Yoshiyuki Toya
Oxidative stress accelerates the development of cardiovascular disease. Plasma cystine, a thiol oxidative stress marker, is related to several established factors for cardiovascular disease risk and prognosis. Although a comprehensive oxidative stress index is clinically required for hemodialysis patients with high oxidative stress, there are few reports concerning thiol oxidative stress markers predicting their prognosis. We investigated the relationship between plasma amino acids including cystine levels and cardiovascular disease-related and all-cause mortality in 132 maintenance hemodialysis patients...
July 2, 2018: Therapeutic Apheresis and Dialysis
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