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Therapeutic Apheresis and Dialysis

journal
https://www.readbyqxmd.com/read/28731276/attempt-to-harvest-a-sufficient-number-of-mononuclear-cells-in-an-appropriate-blood-product-volume-by-modification-of-the-default-apheresis-setting
#1
Yumi Tanaka, Kohshi Ohishi, Toshiki Sawai, Hitoshi Iwasaki, Shinichi Kageyama, Masahiro Masuya, Takeshi Matsumoto, Takashi Tanigawa, Hideo Wada, Hiroshi Shiku, Masaaki Ito, Naoyuki Katayama
To harvest for T cell therapy, a 1.6-fold higher number of CD3(+) T cells was collected with MNC mode (N = 10) compared with Auto PBSC mode (N = 5) in COBE Spectra cell separator, but the blood product volume was increased by 3.5-fold. For therapeutic angiogenesis therapy, apheresis was initially performed using Auto PBSC mode (N = 4) to fine tune the blood product volume to omit cell concentration, but the collected number of mononuclear cells was lower than expected. However, an increase of the harvest cycle number from 3...
July 21, 2017: Therapeutic Apheresis and Dialysis
https://www.readbyqxmd.com/read/28714271/influence-of-residual-renal-function-in-carotid-modeling-as-a-marker-of-early-atherosclerosis-in-dialysis-patients
#2
Merita Rroji, Nereida Spahia, Saimir Seferi, Myftar Barbullushi, Goce Spasovski
Atherosclerosis is frequently present in patients with chronic kidney disease (CKD) treated with dialysis. We evaluated the association between residual renal function (RRF), phosphate level, inflammation and other risk factors in carotid modeling as a marker of early atherosclerosis in peritoneal dialysis (PD) compared with hemodialysis (HD) patients. We studied 39 stable PD and 53 HD patients on renal replacement therapy (RRT) for 3 to 36 months duration. B-mode ultrasonography was used to determine carotid artery intima media thickness (CIMT)...
July 17, 2017: Therapeutic Apheresis and Dialysis
https://www.readbyqxmd.com/read/28714255/hypoglycemic-emergency-in-patients-with-diabetic-kidney-disease
#3
LETTER
Kiyonori Ito, Susumu Ookawara, Yoshiyuki Morishita
No abstract text is available yet for this article.
July 17, 2017: Therapeutic Apheresis and Dialysis
https://www.readbyqxmd.com/read/28714149/elimination-of-plasma-cytokines-markedly-improves-non-septic-multiple-organ-dysfunction-syndrome-in-human-immunodeficiency-virus-associated-hodgkin-lymphoma
#4
LETTER
Maki Fujiwara, Soshi Yanagida, Hiroko Kakita, Nobuyoshi Arima
No abstract text is available yet for this article.
July 17, 2017: Therapeutic Apheresis and Dialysis
https://www.readbyqxmd.com/read/28714124/primary-central-nervous-system-post-transplant-lymphoproliferative-disorder-following-kidney-transplantation-a-multi-institution-study-in-japan-over-30%C3%A2-years
#5
Hiroki Ishihara, Masayoshi Okumi, Kazunari Tanabe
No abstract text is available yet for this article.
July 17, 2017: Therapeutic Apheresis and Dialysis
https://www.readbyqxmd.com/read/28691214/earthquake-preparedness-among-japanese-hemodialysis-patients-in-prefectures-heavily-damaged-by-the-2011-great-east-japan-earthquake
#6
Hidehiro Sugisawa, Yumiko Shimizu, Tamaki Kumagai, Hiroaki Sugisaki, Seiji Ohira, Toshio Shinoda
The purpose of this study was to explore the factors related to earthquake preparedness in Japanese hemodialysis patients. We focused on three aspects of the related factors: health condition factors, social factors, and the experience of disasters. A mail survey of all the members of the Japan Association of Kidney Disease Patients in three Japanese prefectures (N = 4085) was conducted in March, 2013. We obtained 1841 valid responses for analysis. The health factors covered were: activities of daily living (ADL), mental distress, primary renal diseases, and the duration of dialysis...
July 10, 2017: Therapeutic Apheresis and Dialysis
https://www.readbyqxmd.com/read/28665535/pre-dialysis-neutrophil-lymphocyte-ratio-a-novel-and-strong-short-term-predictor-of-all-cause-mortality-in-patients-with-diabetic-nephropathy-results-from-a-single-center-study
#7
Hiroyuki Sato, Yoichi Takeuchi, Ken Matsuda, Saeko Kagaya, Ayako Saito, Hirotaka Fukami, Yoshie Ojima, Tasuku Nagasawa
Neutrophil-lymphocyte ratio (NLR) is an inflammatory marker affecting the prognosis of end-stage renal disease (ESRD) patients. This study aimed to evaluate NLR levels predicting all-cause mortality in ESRD patients with diabetic nephropathy (DN), which have not been evaluated. We recruited 151 isolated DN patients who started hemodialysis between January 2009 and December 2014 at the Japanese Red Cross Ishinomaki Hospital. The primary outcomes were 1- and 3-year survival rates. The association between NLR and survival rate was evaluated using the Kaplan-Meier method and Cox proportional hazard regression analysis...
June 30, 2017: Therapeutic Apheresis and Dialysis
https://www.readbyqxmd.com/read/28597511/successful-treatment-of-enterohemorrhagic-escherichia-coli-induced-acute-encephalopathy-and-hemolytic-uremic-syndrome-with-polymyxin-b-direct-hemoperfusion
#8
Hisashi Kaneda, Masaki Shimizu, Akihiro Yachie
No abstract text is available yet for this article.
June 8, 2017: Therapeutic Apheresis and Dialysis
https://www.readbyqxmd.com/read/28594111/bone-histomorphometry-in-an-osteoporotic-hemodialysis-patient-treated-with-denosumab
#9
Yajima Ibuki, Toyosi Hukuda, Sakuyosi Tabata, Akemi Ito
No abstract text is available yet for this article.
June 8, 2017: Therapeutic Apheresis and Dialysis
https://www.readbyqxmd.com/read/28593648/evaluation-of-first-line-sorafenib-treatment-for-metastatic-renal-cell-carcinoma-in-kidney-transplant-patients-a-single-center-experience-with-four-cases
#10
LETTER
Hiroki Ishihara, Tsunenori Kondo, Kazunari Tanabe
No abstract text is available yet for this article.
June 8, 2017: Therapeutic Apheresis and Dialysis
https://www.readbyqxmd.com/read/28544682/hypertension-induced-by-tyrosine-kinase-inhibitors-for-the-treatment-of-renal-cell-carcinoma-in-hemodialysis-patients-a-single-center-experience-and-review-of-the-literature
#11
Kentaro Nakai, Hideki Fujii, Keiji Kono, Shunsuke Goto, Shinichi Nishi
Malignancy is a major cause of mortality in dialysis patients. Although molecular-targeted anticancer drugs, including tyrosine-kinase inhibitors, are used for advanced renal cell carcinoma treatment, there are few reports on their effectiveness and safety in dialysis patients. Renal cell carcinoma dialysis patients treated at our hospital from 2010 to 2013 participated in this study. Thirteen patients were treated with tyrosine-kinase inhibitors and 15 patients with surgery only (control group). During treatment, blood pressure changes and dry weight reduction tended to be greater in the tyrosine-kinase inhibitor group than in controls...
May 23, 2017: Therapeutic Apheresis and Dialysis
https://www.readbyqxmd.com/read/28524584/carvedilol-associated-hypoglycemia-in-a-diabetic-patient-on-maintenance-hemodialysis
#12
LETTER
Michitaka Maekawa, Ayako Takahashi, Yusuke Miki
No abstract text is available yet for this article.
May 19, 2017: Therapeutic Apheresis and Dialysis
https://www.readbyqxmd.com/read/28524545/phosphate-or-phosphorus-removal-during-nocturnal-hemodialysis-are-we-using-correct-terms
#13
LETTER
Jadranka Buturovic Ponikvar, Tina Zupancic, Jakob Gubenšek, Rafael Ponikvar
No abstract text is available yet for this article.
May 19, 2017: Therapeutic Apheresis and Dialysis
https://www.readbyqxmd.com/read/28508588/at-the-cross-section-of-thrombotic-microangiopathy-and-atypical-hemolytic-uremic-syndrome-a-narrative-review-of-differential-diagnostics-and-a-problematization-of-nomenclature
#14
REVIEW
Alexander Åkesson, Eva Zetterberg, Jenny Klintman
Complement-mediated atypical hemolytic uremic syndrome (aHUS) is a rare disease associated with high mortality and morbidity. Renal biopsies often indicate thrombotic microangiopathy (TMA). The condition is caused by an excessive activation of the alternative pathway leading to depositions of membrane attack complexes (MAC) on host cells. It may depend on mutations in complement components and regulatory proteins, or the formation of complement-specific antibodies. Mainly, an environmental trigger (e.g. infection) is needed for the excessive response to develop...
May 16, 2017: Therapeutic Apheresis and Dialysis
https://www.readbyqxmd.com/read/28508563/safety-aspects-of-immunoadsorption-in-igg-removal-using-a-single-use-multiple-pass-protein-a-immunoadsorber-ligasorb-clinical-investigation-in-healthy-volunteers
#15
Sven Süfke, Hendrik Lehnert, Ingrid Uhlenbusch-Körwer, Frank Gebauer
Therapeutic apheresis and immunoadsorption are used to deplete efficiently pathogenic autoantibodies in crises in several acute autoimmune driven diseases. This prospective, non-comparative cohort study was conducted at a single study center under standardized conditions in 10 healthy volunteers. Efficient immunoglobulin G (IgG) removal (-86% versus baseline) was achieved after 3 apheresis treatments on 3 consecutive days. The treatments were well tolerated. Safety laboratory parameters did not show unexpected or pathological changes...
May 15, 2017: Therapeutic Apheresis and Dialysis
https://www.readbyqxmd.com/read/28508538/prognostic-value-of-predialysis-indices-for-technique-failure-and-mortality-in-peritoneal-dialysis-patients
#16
Masaru Matsui, Yasuhiro Akai, Ken-Ichi Samejima, Hideo Tsushima, Kaori Tanabe, Katsuhiko Morimoto, Miho Tagawa, Yoshihiko Saito
Technique failure remains a frequent cause of peritoneal dialysis (PD) withdrawal. Many post-commencement predictors of PD technique failure have been identified, while predialysis predictors have remained unclear. The aim of this study was to identify predialysis indices for technique failure in PD patients. We recruited 206 consecutive PD patients who were treated at Nara Medical University Hospital between 1 April 1997 and 31 December 2012. Forty-eight patients were excluded because of transition from hemodialysis (HD) or withdrawal from PD within 3 months, leaving 158 patients for analysis...
May 15, 2017: Therapeutic Apheresis and Dialysis
https://www.readbyqxmd.com/read/28498647/association-between-staphylococcus-aureus-bacteremia-and-hospital-mortality-in-hemodialysis-patients-with-bloodstream-infection-a-multicenter-cohort-from-japanese-tertiary-care-centers
#17
Takahiro Imaizumi, Takeshi Hasegawa, Atsushi Nomura, Sho Sasaki, Hiroki Nishiwaki, Takaya Ozeki, Hideaki Shimizu, Shun Minatoguchi, Taishi Yamakawa, Masahiko Yazawa, Daisuke Uchida, Hiroo Kawarazaki, Masahito Miyamoto, Tomo Suzuki, Ken'ichiro Koitabashi, Masahide Furusho, Yoshiro Fujita
Multiple studies have shown that Staphylococcus aureus bacteremia (SAB) has been a major cause of death in hemodialysis patients. We examined whether SAB is a risk for mortality among chronic hemodialysis patients in Japan where the standard vascular access is arteriovenous fistula (AVF). This was a multicenter, retrospective study of maintenance hemodialysis patients with bloodstream infection (BSI) from 2011 to 2013 at tertiary care centers in Japan. The endpoint was hospital mortality. Our cohort contained 32 SAB cases (14 MRSA and 18 MSSA) and 42 non-SAB cases...
May 12, 2017: Therapeutic Apheresis and Dialysis
https://www.readbyqxmd.com/read/28452109/implications-of-albumin-leakage-for-survival-in-maintenance-hemodialysis-patients-a-7-year-observational-study
#18
Kojiro Nagai, Kenji Tsuchida, Noriyuki Ishihara, Naoto Minagawa, Go Ichien, Satoshi Yamada, Daisuke Hirose, Hiroyuki Michiwaki, Hiro-Omi Kanayama, Toshio Doi, Jun Minakuchi
Albumin leakage during hemodialysis (HD) presents a clinical dilemma. However, protein-binding uremic toxins are suggested to be responsible for increased mortality. No one has investigated the relationship between albumin leakage and mortality. Therefore, the purpose of this observational study was to analyze the association of albumin leakage with mortality in 690 HD patients who survived one year after enrollment. They were divided to three groups who received HD with large (3 g or more per HD session), middle (1 to 3 g) or small (less than 1 g) amount of albumin leakage, respectively...
April 27, 2017: Therapeutic Apheresis and Dialysis
https://www.readbyqxmd.com/read/28661098/efficacy-of-cryofiltration-for-treatment-of-mixed-cryoglobulinemia-a-report-of-four-cases
#19
Yoshihiro Taniyama, Yoshihisa Nakatani, Toshiaki Matsuoka, Miyo Takahashi, Kazuyuki Shimizu, Sachiyo Yamamoto, Yuki Inoue, Sayoko Ohnishi, Norihiro Kobayashi, Yukihito Nakano, Masahiro Takami, Shuji Arima
Cryoglobulinemia can induce systemic vasculitis affecting various organs such as skin, peripheral nerves, and kidney. The disease can induce chronic organ failure and even be life-threatening. Cryofiltration has been applied for the treatment of cryoglobulinemic vasculitis. We have experienced four cases with mixed cryoglobulinemia showing severe and progressive clinical manifestations, including skin purpura, nephrotic syndrome, acute kidney injury, and peripheral neuropathy. Cryofiltration in conjunction with conventional pharmacological therapies appeared to be safe and effective...
June 2017: Therapeutic Apheresis and Dialysis
https://www.readbyqxmd.com/read/28661097/evaluating-the-efficacy-of-double-filtration-plasmapheresis-in-treating-five-patients-with-drug-resistant-pemphigus
#20
Takaaki Higashihara, Masaaki Kawase, Maasa Kobayashi, Mizuki Hara, Hiroyuki Matsuzaki, Rie Uni, Mimiko Matsumura, Takafumi Etoh, Hideki Takano
Double-filtration plasmapheresis is an effective and safe treatment for pemphigus. We retrospectively evaluated the decrease in autoantibody titer and pemphigus disease area index following double-filtration plasmapheresis in five patients with moderate to severe pemphigus, who were physically and/or serologically unresponsive to 1.0 mg/kg per day of prednisolone and other supportive drugs and ointments. The percentage reduction in autoantibodies 85.6 ± 14.4% (P = 0.00014), and that in pemphigus disease area index was 75...
June 2017: Therapeutic Apheresis and Dialysis
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