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Therapeutic Apheresis and Dialysis

Yasushi Suzuki, Masahiro Kojika, Hisaho Sato, Yoshihiro Inoue, Shigeatsu Endo
Direct hemoperfusion with polymyxin B-immobilized fiber (PMX-DHP) has been widely used for severe sepsis and septic shock. However, data are limited regarding the clinical experience and efficacy of PMX-DHP for septic shock resulting from urinary tract infection (UTI). At our institution, 15 patients with septic shock resulting from a UTI received PMX-DHP from January 2013 to July 2017. The cause of the urosepsis was mainly obstructive pyelonephritis secondary to ureterolithiasis or neurogenic bladder. Average Acute Physiology and Chronic Health Evaluation II (APACHE II) and Sequential Organ Failure Assessment (SOFA) scores were 25...
September 12, 2018: Therapeutic Apheresis and Dialysis
Keita Kanamori, Satoko Tsuchida, Masamichi Tamura
No abstract text is available yet for this article.
September 10, 2018: Therapeutic Apheresis and Dialysis
Yoshinari Oka, Masashi Miyazaki, Hiroaki Matsuda
No abstract text is available yet for this article.
September 7, 2018: Therapeutic Apheresis and Dialysis
Alexis R Peedin, Yara A Park, Marshall A Mazepa, Marian A Rollins-Raval, Mark E Brecher, Jay S Raval
Acquired thrombotic thrombocytopenic purpura (TTP) is characterized by microangiopathic hemolytic anemia, thrombocytopenia, and commonly ADAMTS13 deficiency. Patients with TTP and severe ADAMTS13 deficiency have high risk of disease recurrence, yet the ability to predict which patients will have recurrence remains limited. We assessed whether the presence of persistent schistocytes in TTP patients with severe ADAMTS13 deficiency at the time of daily therapeutic plasma exchange (TPE) discontinuation was predictive of disease recurrence...
September 3, 2018: Therapeutic Apheresis and Dialysis
Wibke Bechtel-Walz, Gerd Walz, Elke Neumann-Haefelin
No abstract text is available yet for this article.
August 20, 2018: Therapeutic Apheresis and Dialysis
Tomomi Okubo, Masanori Atsukawa, Akihito Tsubota, Mai Koeda, Yuji Yoshida, Taeang Arai, Ai Nakagawa-Iwashita, Norio Itokawa, Chisa Kondo, Shunji Fujimori, Shuichi Tsuruoka, Katsuhiko Iwakiri
Nowadays, interferon-free direct-acting antiviral (DAA) treatment is the standard of care for chronic hepatitis C patients. Some DAA regimens are highly effective and safe even for those with renal dysfunction/failure including those receiving HD. However, it remains unclear to what extent HD specialists gain knowledge about advances in anti-hepatitis C virus (HCV) treatment. To clarify the current situation and identify problems in the treatment of HD patients with chronic hepatitis C, we performed a questionnaire survey at 36 HD facilities between June 2016 and September 2017...
August 20, 2018: Therapeutic Apheresis and Dialysis
Sweta Nayak, Raj Nath Makroo, Bindu Prakash, Trilok Chandra, Soma Agrawal, Mohit Chowdhry, Archisman Mohapatra
The accurate estimation of ABO antibody titers is of the utmost importance in organ transplants involving ABO incompatibility. We aim to compare five different methods of titration and analyze the data. Samples of 48 O group blood donors who donated during the month of December 2015 to January 2016 in our institution were subjected to ABO antibody titration by five different methods: immediate spin (IS) tube titer, antihuman globulin phase tube titer, Coomb's gel card titer, gel card titer after dithiotreitol (DTT) treatment of plasma, and the solid phase red cell adherence method...
August 20, 2018: Therapeutic Apheresis and Dialysis
Keren Cohen-Hagai, Andy Kotliroff, Ilan Rozenberg, Zeev Korzets, Tali Zitman-Gal, Sydney Benchetrit
Infection is one of the leading causes of mortality in dialysis patients, second only to cardiovascular disease. This retrospective study assessed the efficacy and clinical outcomes of influenza vaccination among hemodialysis (HD) patients. In the 2014-2015 season, 104 of 164 (63.6%) HD patients were vaccinated for influenza by the outpatient community health system facilities. Significantly more patients, 159 of 170 (93.8%), were vaccinated in 2015-2016 by the hospital dialysis unit staff during an inpatient HD session (P <0...
August 19, 2018: Therapeutic Apheresis and Dialysis
Jing Wang, Meng-Meng Lv, Odeh Zach, Ling-Yu Wang, Meng-Ying Zhou, Gui-Rong Song, Xu Zhang, Hong-Li Lin
Hyperkalemia is a life-threatening emergency in maintenance hemodialysis (MHD) patients. This clinical trial investigated the efficacy and safety of calcium-polystyrene sulfonate (Ca-PS) in MHD patients with interdialytic hyperkalemia. A total of 58 hemodialysis patients with hyperkalemia (≥5.5 mol/L) were selected and administered either a 3-week Ca-PS (3 × 5 g/day) or a blank control following the model of a prospective, randomized, crossover clinical trial with a 1-week washout period. All patients were followed up for another 3 weeks for safety evaluations...
August 14, 2018: Therapeutic Apheresis and Dialysis
Shoichiro Daimon
Antithrombotic medications (AM) are mandatory for many hemodialysis patients, but the bleeding risk associated with this therapy is elevated. The frequency of bleeding events requiring discontinuation of AM, cessation of heparin use, and/or hospitalization was compared between hemodialysis patients with and without AM. All the hemodialysis patients in our clinic were investigated. AM were prescribed in 130 of 222 patients. Except for patients with cilostazol, those with AM had significantly more frequent bleeding events than those without AM (P < 0...
August 8, 2018: Therapeutic Apheresis and Dialysis
Merita Rroji, Andreja Figurek, Goce Spasovski
No abstract text is available yet for this article.
July 31, 2018: Therapeutic Apheresis and Dialysis
Yaya Zhao, Xiaohua Pei, Weihong Zhao
The optimal time of dialysis initiation among patients with chronic kidney disease (CKD) is unclear in recent years. We performed a meta-analysis to assess the association of early vs. late initiation of dialysis with estimated glomerular filtration rate. PUBMED, EMBASE, the Cochrane Library, and article reference lists were searched for relevant observational trials. A pooled hazard ratio (HR) with 95% CI was used to estimate the mortality risk. Twenty-six cohort studies and one randomized controlled trial were identified...
July 31, 2018: Therapeutic Apheresis and Dialysis
Li Li, Qingsong Wan, Shikun Yang, Saili Zhao
Our pooled analysis aimed to assess the impact of vitamin D receptor (VDR) gene polymorphism on chronic renal failure (CRF) susceptibility. Relevant studies were searched from multiple databases, then pooled-analyses were performed using Stata software. Eighteen studies involving 2512 CRF patients and 3630 healthy controls were included. Pooled analysis showed that VDR ApaI and TaqI gene polymorphism were not associated with CRF susceptibility either in Asian or in Caucasians populations, and VDR BsmI and FokI gene polymorphism were not associated with CRF susceptibility in overall populations...
July 30, 2018: Therapeutic Apheresis and Dialysis
Werner Keenswijk, Gina Sinclair, Marian Benetton, Mandi du Plessis, Peter Nourse, Deveshni Reddy, Mignon McCulloch
Peritoneal dialysis and kidney transplantation remain the preferred choices for renal replacement therapy in young children. These options, however, are not always feasible, and hemodialysis (HD) is therefore an accepted alternative. In small children presenting with end-stage renal disease, HD presents several challenges and is often unavailable in lower- and middle-income countries. To assess these challenges and outcomes of maintenance HD in young children, we performed an audit of children below 20 kg with end-stage renal disease, receiving HD for ≥4 weeks, from 1 January 2008 to 31 July 2016 at the Red Cross War Memorial Children's Hospital...
July 30, 2018: Therapeutic Apheresis and Dialysis
Yuki Hattori, Tatsuhiko Miyazaki, Mariko Seishima
No abstract text is available yet for this article.
July 30, 2018: Therapeutic Apheresis and Dialysis
António Norton de Matos, Clemente N Sousa, Paulo Almeida, Paulo Teles, Duarte Rego, Gabriela Teixeira, Luís Loureiro, Sérgio Teixeira, Inês Antunes
Vascular access dysfunction is a serious problem in dialysis units. Some patients have complex dysfunctions that are difficult to resolve. In this article, we report the case a of two patients with radiocephalic arteriovenous fistulae (RC-AVF) who had stenosis/occlusion of the forearm median vein and where we used the basilic vein of the forearm as a solution. We reviewed the use of this surgical solution in RC-AVF. Two male patients on hemodialysis exhibited stenosis/occlusion of the forearm median vein. The forearm basilic vein was isolated and rotated toward the forearm median vein in order to solve RC-AVF problems...
July 25, 2018: Therapeutic Apheresis and Dialysis
Tadao Akizawa, Hiroyuki Okumura, Ana Filipa Alexandre, Ayako Fukushima, Grace Kiyabu, Julie Dorey
Anemia is a common complication for patients with chronic kidney disease (CKD) and is associated with cardiovascular comorbidities and reduced quality of life. The incidence of anemia increases as kidney function declines and affects approximately 32% of Japanese patients with stage 3-5 CKD. This review examined the current literature on anemia in CKD patients in Japan to provide an overview of the burden of anemia in CKD. Medline, Embase, and Igaku Chuo Zasshi databases were searched to identify relevant manuscripts and abstracts published from 2004 onward...
July 18, 2018: Therapeutic Apheresis and Dialysis
Taro Hoshino, Shohei Kaneko, Saori Minato, Katsunori Yanai, Yuko Mutsuyoshi, Hiroki Ishii, Taisuke Kitano, Mitsutoshi Shindo, Haruhisa Miyazawa, Akinori Aomatsu, Kiyonori Ito, Yuichiro Ueda, Keiji Hirai, Susumu Ookawara, Yoshiyuki Morishita
High concentrations of lactate are considered to contribute to impairment of the peritoneal membrane. We investigated the longer-period effects of bicarbonate/lactate-buffered neutral peritoneal dialysis fluid (PDF) in patients undergoing PD for about 2 years. Patients undergoing PD were changed from a lactate-buffered neutral PDF to a bicarbonate/lactate-buffered neutral PDF. We then investigated the patients' clinical outcomes and peritoneal membrane functions as well as the surrogate markers in the drained dialysate...
July 16, 2018: Therapeutic Apheresis and Dialysis
Akihito Tanaka, Daijo Inaguma, Yu Watanabe, Takahiro Mizukawa, Hibiki Shinjo, Kiyomi Koike, Yasuhiro Otsuka, Asami Takeda
The rate of hepatitis B infection among hemodialysis patients is high. However, it is not clear if this rate reflects the infection rate among patients with chronic kidney disease (CKD). Therefore, we evaluated the rate of hepatitis B infection among patients with CKD. This is an important clinical issue when considering the risk of infection to medical staff when performing invasive procedures in this clinical population. A retrospective, observational study was conducted among stable, non-dialysis patients with CKD who attended a CKD educational program at our hospital, between August 2012 and October 2017...
July 15, 2018: Therapeutic Apheresis and Dialysis
Mohamed Momtaz, Ahmed Fayed, Khaled Marzouk, Amr Shaker
Therapeutic plasma exchange is used in treating different immunological and non-immunological diseases. We analyzed the outcome of 308 patients treated by 1783 membrane plasma exchange sessions from January 2011 until January 2017 at Cairo University Hospital. Thrombotic microangiopathies were the commonest indication [73 (23.7%) patients] with response in 63/73 patients (86.3%), followed by systemic vasculitis with pulmonary-renal involvement [40(13%) patients] with recovery in 32/40 patients (80.0%), Guillain-Barré syndrome [39(12...
July 15, 2018: Therapeutic Apheresis and Dialysis
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