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Chinese Journal of Integrative Medicine

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https://www.readbyqxmd.com/read/28432529/ginseng-derived-panaxadiol-saponins-promote-hematopoiesis-recovery-in-cyclophosphamide-induced-myelosuppressive-mice-potential-novel-treatment-of-chemotherapy-induced-cytopenias
#1
Xin Sun, Yan-Na Zhao, Song Qian, Rui-Lan Gao, Li-Ming Yin, Li-Pei Wang, Beng-Hock Chong, Su-Zhan Zhang
OBJECTIVE: To investigate the potential efficacy of panaxadiol saponins component (PDS-C), a biologically active fraction isolated from total ginsenosides, to reverse chemotherapy-induced myelosuppression and pancytopenia caused by cyclophamide (CTX). METHODS: Mice with myelosuppression induced by CTX were treated with PDS-C at a low- (20 mg/kg), moderate- (40 mg/kg), or high-dose (80 mg/kg) for 7 consecutive days. The level of peripheral white blood cell (WBC), neutrophil (NEU) and platelet (PLT) were measured, the histopathology and colony formation were observed, the protein kinase and transcription factors in hematopoietic cells were determined by immunohistochemical staining and Western blot...
April 22, 2017: Chinese Journal of Integrative Medicine
https://www.readbyqxmd.com/read/28432528/conventional-acupuncture-for-cardiac-arrhythmia-a-systematic-review-of-randomized-controlled-trials
#2
Jing Liu, Si-Nai Li, Lu Liu, Kun Zhou, Yan Li, Xiao-Yun Cui, Jie Wan, Jin-Jin Lu, Yan-Chao Huang, Xu-Sheng Wang, Qian Lin
OBJECTIVE: To exam the effect and safety of conventional acupuncture (CA) on cardiac arrhythmia. METHODS: Nine medical databases were searched until February 2016 for randomized controlled trials. Heterogeneity was measured by Cochran Q test. Meta-analysis was conducted if I(2) was less than 85% and the characteristics of included trials were similar. RESULTS: Nine qualified studies involving 638 patients were included. Only 1 study had definitely low risk of bias, while 7 trials were rated as unclear and 1 as high...
April 22, 2017: Chinese Journal of Integrative Medicine
https://www.readbyqxmd.com/read/28337641/inhibition-of-proliferation-of-prostate-cancer-cell-line-du-145-in-vitro-and-in-vivo-using-salvia-miltiorrhiza-bunge
#3
Woong Jin Bae, Jin Bong Choi, Kang Sup Kim, U Syn Ha, Sung Hoo Hong, Ji Youl Lee, Tae-Kon Hwang, Sung Yeoun Hwang, Zhi-Ping Wang, Sae Woong Kim
OBJECTIVE: To investigate the antiproliferative activity of Salvia miltiorrhiza Bunge. (SM) on the castration-resistant prostate cancer (CRPC) cell line DU-145, in vitro and in vivo. METHODS: Prostate cancer cell line (DU-145) and normal prostate cell line (RWPE-1) were treated with SM at different concentrations (3.125, 12.5, 25 and 50 μg/mL) to investigate the antiproliferative effects. DNA laddering analysis was performed to investigate the apoptosis of DU-145 cells...
March 23, 2017: Chinese Journal of Integrative Medicine
https://www.readbyqxmd.com/read/28283936/in-vivo-and-in-vitro-anti-inflammatory-effects-of-ethanol-fraction-from-periploca-forrestii-schltr
#4
Li Dong, Yun Zhang, Xia Wang, Yong-Xi Dong, Lin Zheng, Yong-Jun Li, Jing-Man Ni
OBJECTIVE: To determine the anti-inflammatory effects of an ethanol fraction of Periploca forrestii Schltr. (EFPF) and to investigate the potential mechanisms underlying in vivo and in vitro models. METHODS: The antiinflammatory effects of EFPF were evaluated using the xylene-induced mouse ear edema and carrageenan-induced rat paw edema models in vivo. In vitro, RAW264.7 cells were exposed to 0-800 μg/mL EFPF and the cell viability was determined by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay...
March 10, 2017: Chinese Journal of Integrative Medicine
https://www.readbyqxmd.com/read/28251475/chinese-medicines-reported-to-have-effects-on-contact-dermatitis-in-the-last-20-years
#5
REVIEW
Youngchul Jung, Byungju Kim, Mi Heon Ryu, Hyungwoo Kim
Contact dermatitis (CD) is one of the most common skin diseases in industrialized countries. Chinese medicines (CMs) have been investigated worldwide as complementary and alternative medicines for corticosteroids, which are the first choice for treatment of inflammatory skin diseases owing to their favorable efficacy. This article describes the CMs that have been reported to have anti-dermatitis effects against CD in the last 20 years.
March 2, 2017: Chinese Journal of Integrative Medicine
https://www.readbyqxmd.com/read/28197938/clinical-efficacy-and-safety-of-bathing-with-chinese-medicine-taohong-siwu-decoction-for-treatment-of-diffuse-cutaneous-systemic-sclerosis-a-randomized-placebo-controlled-trial
#6
Jing Zhou, Dong Yang, Shu-Hong Zhou, Jin-Ping Wang, Yue-Shu Liu, Shu-Lan Wang
OBJECTIVE: To examine the efficacy and safety of bathing therapy with Taohong Siwu Decoction (, TSD) in the treatment of early-stage, mild-moderate diffuse cutaneous systemic sclerosis (dcSSc). METHODS: This randomized, placebo-controlled trial enrolled 148 men and women (18-60 years) with dcSSc (disease duration ≤12 months) and baseline modified Rodnan skin score (MRSS) ≥10. Patients were randomized into a TSD group (71 cases bathing with TSD plus oral prednisone) or control group (71 cases bathing with placebo plus oral prednisone)...
February 15, 2017: Chinese Journal of Integrative Medicine
https://www.readbyqxmd.com/read/28197937/association-of-platelet-activating-factor-receptor-gene-rs5938-g-t-and-rs313152-t-c-polymorphisms-with-coronary-heart-disease-and-blood-stasis-syndrome-in-a-chinese-han-population
#7
Guo-Hua Zheng, Shang-Quan Xiong, Hai-Ying Chen, Li-Juan Mei, Ting Wang
OBJECTIVE: To explore the association of the platelet-activating factor receptor (PAFR) gene rs5938, rs313152 and rs76744145 polymorphisms with coronary heart disease (CHD) and blood stasis syndrome (BSS) of CHD in Chinese Han population. METHODS: A total of 570 CHD patients (299 with BSS and 271 with non-BSS) and 317 controls were enrolled. The PAFR gene rs5938, rs313152 and rs76744145 polymorphisms were genotyped using the multiplex SNaPshot technology. The statistical analysis was conducted using a multiple variable logistic regression model...
February 15, 2017: Chinese Journal of Integrative Medicine
https://www.readbyqxmd.com/read/28197936/salvianolic-acid-a-protects-neonatal-cardiomyocytes-against-hypoxia-reoxygenation-induced-injury-by-preserving-mitochondrial-function-and-activating-akt-gsk-3%C3%AE-signals
#8
Xue-Li Li, Ji-Ping Fan, Jian-Xun Liu, Li-Na Liang
OBJECTIVE: To investigate the effects of salvianolic acid A (SAA) on cardiomyocyte apoptosis and mitochondrial dysfunction in response to hypoxia/reoxygenation (H/R) injury and to determine whether the Akt signaling pathway might play a role. METHODS: An in vitro model of H/R injury was used to study outcomes on primary cultured neonatal rat cardiomyocytes. The cardiomyocytes were treated with 12.5, 25, 50 μg/mL SAA at the beginning of hypoxia and reoxygenation, respectively...
February 15, 2017: Chinese Journal of Integrative Medicine
https://www.readbyqxmd.com/read/28197935/anti-inflammatory-effect-of-total-saponin-fraction-from-dioscorea-nipponica-makino-on-gouty-arthritis-and-its-influence-on-nalp3-inflammasome
#9
Qi Zhou, Dong-Hua Yu, Ning Zhang, Shu-Min Liu
OBJECTIVE: To investigate the mechanism of Chinese herbal medicine Dioscorea nipponica for the treatment of monosodium urate crystals-induced gouty arthritis (GA) in rats. METHODS: Sixty male Wistar rats were divided into 6 groups: normal, model, indomethacin and three total saponin (900, 300 and 100 mg/kg) groups. The liver, kidney and serum levels of lysosomal enzymes, antioxidant capacities, and inflammatory factors were measured. In addition, the mRNA and protein levels of the NALP3 inflammasome components in the mononuclear cells of rats' peripheral blood were analyzed using real-time polymerase chain reaction and Western blotting methods, respectively...
February 15, 2017: Chinese Journal of Integrative Medicine
https://www.readbyqxmd.com/read/28197934/fuzheng-huayu-formula-prevents-rat-renal-interstitial-fibrosis-induced-by-hgcl2-via-antioxidative-stress-and-down-regulation-of-nuclear-factor-kappa-b-activity
#10
Ji-Li Yuan, Yan-Yan Tao, Qing-Lan Wang, Li Shen, Cheng-Hai Liu
OBJECTIVE: To investigate the mechanism of action of Fuzheng Huayu Formula (, FZHY) against renal interstitial fibrosis (RIF) relating to oxidative injury and nuclear factor-kappa B (NF-κB) activity. METHODS: Thirty-two Sprague-Dawley rats were randomly divided into 3 groups: control group, model group and FZHY treatment group. The RIF model was induced by oral administration of HgCl2 at a dose of 8 mg/kg body weight once a day for 9 weeks. Meanwhile, rats in FZHY treatment group orally took FZHY at a dose of 4...
February 15, 2017: Chinese Journal of Integrative Medicine
https://www.readbyqxmd.com/read/28197933/garlic-extract-attenuates-immobilization-stress-induced-alterations-in-plasma-antioxidant-oxidant-parameters-and-hepatic-function-in-rats
#11
Syed Kashif Zaidi, Shakeel Ahmed Ansari, Shams Tabrez, Md Nasrul Hoda, Ghulam Md Ashraf, Mohd Shahnawaz Khan, Sultan Alnohair, Naheed Banu, Mohammed Hussain Al-Qahtani
OBJECTIVE: To investigate the oxidative stress induced by 6 h of immobilization stress in Albino Wistar rats. Further, the pre- and post-treatment of aqueous garlic extract was studied to evaluate its preventive and curative efficacy on stress-induced altered oxidative parameters in rats. METHODS: Albino Wistar rats were exposed to 6 h of immobilization stress, and received garlic extract (100 mg/kg body weight) treatment pre- or post-stress exposure. The oxidative status of plasma after various treatments were evaluated by determining the levels of reduced glutathione, glucose, uric acid, thiobarbituric acid reactive substances, aspartate aminotransferase (AST), alanine transaminase (ALT), alkaline phosphatase (ALP) and the activities of superoxide dismutase, catalase and glutathione-S-transferase by standardized procedures...
February 15, 2017: Chinese Journal of Integrative Medicine
https://www.readbyqxmd.com/read/28364352/effects-of-bufalin-on-up-regulating-methylation-of-wilm-s-tumor-1-gene-in-human-erythroid-leukemic-cells
#12
Li-Pei Wang, Yan-Na Zhao, Xin Sun, Rui-Lan Gao
OBJECTIVE: To explore the effects of bufalin on inhibiting proliferation, up-regulating methylation of Wilm' tumor 1 gene (WT1) as well as its possible mechanisms in human erythroid leukemic (HEL) cells. METHODS: The HEL cells were treated with bufalin at various concentrations to observe cellular morphology, proliferation assay and cell cycle. The mRNA and protein expression levels of WT1 were detected by reverse transcription polymerase chain reaction (RT-PCR), Western blot and immunocytochemistry, DNA methylation of WT1 and protein expression levels of DNA methyltransferase 3a (DNMT3a) and DNMT3b were analyzed by methylation-specific PCR, and Western blot respectively...
April 2017: Chinese Journal of Integrative Medicine
https://www.readbyqxmd.com/read/28120208/huannao-yicong-formula-regulates-%C3%AE-secretase-activity-through-aph-1-and-pen-2-gene-ragulation-pathways-in-hippocampus-of-app-ps1-double-transgenic-mice
#13
Zhi-Yong Wang, Jian-Gang Liu, Yun Wei, Mei-Xia Liu, Qi Wang, Lin Liang, Hui-Min Yang, Hao Li
OBJECTIVE: To observe the effects of Huannao Yicong Formula (, HYF) on learning and memory and it's regulating effect on γ-secretase related anterior pharynx defective 1 (APH-1), presenilin enhancer-2 (PEN-2) signaling pathway, so as to discuss and further clarify the mechanism of HYF on Alzheimer's disease. METHODS: Sixty APP/PS1 transgenic mice, randomly allocated into 4 groups, the model group, the donepezil group (0.65 mg/kg), HYF low-dose group (HYF-L, 5.46 g/kg) and HYF high-dose group (HYF-H, 10...
April 2017: Chinese Journal of Integrative Medicine
https://www.readbyqxmd.com/read/27921196/danshen-injection-as-adjuvant-treatment-for-unstable-angina-pectoris-a-systematic-review-and-meta-analysis
#14
REVIEW
Jia-Rui Wu, Shi Liu, Xiao-Meng Zhang, Bing Zhang
OBJECTIVE: To systematically evaluate the clinical effectiveness and safety of Danshen Injection (, DS) as one adjuvant treatment for conventional therapy with Western medicine (WM) for unstable angina pectoris (UAP). METHODS: Using literature databases, a thorough and systematic retrieval of randomized controlled trials (RCTs) comparing DS plus WM with WM was conducted from inception to April 2015. The extracted data from included studies was analyzed by Review Manager 5...
April 2017: Chinese Journal of Integrative Medicine
https://www.readbyqxmd.com/read/27921195/new-developments-in-the-pharmacodynamics-and-pharmacokinetics-of-combination-of-chinese-medicine-and-western-medicine
#15
REVIEW
Di Liu, Xiao-Chun Liang
It is very common to use Chinese medicine (CM) combined with Western medicine (WM) in clinical practice. The appropriate combination of CM with WM can reduce toxicity and enhance effects in order to make the best use of advantages and bypass the disadvantages. However, an inappropriate combination can not only affect the curative effect but even cause death. Therefore, strengthening the complementary advantages of the CM and WM to improve the therapeutic efficacy and reduce side effects has become an important research topic of clinical medicine and pharmacy...
April 2017: Chinese Journal of Integrative Medicine
https://www.readbyqxmd.com/read/27484764/chinese-medicine-as-complementary-therapy-for-female-infertility
#16
REVIEW
Ju-Feng Xia, Yoshinori Inagaki, Jian-Feng Zhang, Ling Wang, Pei-Pei Song
Chinese medicine (CM) has been used in clinical treatment for thousands of years in China, Japan, Korea, and other countries. CM is at present attracting many attentions around the world for reproductive health care and disease prevention, including treatment of female infertility. This review focuses on the CM treatment for female infertility patients, and supplies a summary on the efficacy, safety, and mechanism of some Chinese herbal medicines, herbal medicine-derived active compounds, and acupuncture. A large number of researches have reported that CM could alleviate or even cure female infertility by regulating hormone, improving reproductive outcome of in vivo fertilization, affecting embryonic implantation, curing polycystic ovarian syndrome, endometriosis, pelvic inflammatory disease, relieving mental stress, and regulating immune system...
April 2017: Chinese Journal of Integrative Medicine
https://www.readbyqxmd.com/read/27225294/is-chinese-herbal-medicine-effective-for-elderly-isolated-systolic-hypertension-a-systematic-review-and-meta-analysis
#17
REVIEW
Yu Cao, Long-Tao Liu, Min Wu
OBJECTIVE: To study the efficacy of Chinese medicine (CM) on isolated systolic hypertension. METHODS: Seven electronic databases were searched for randomized controlled trials (RCTs) published until August 2015. Subgroup analyses and meta-analysis were performed to assess the efficacy and safety of the included studies. RESULTS: A total of 24 studies, including 2,096 patients (1,058 patients in the intervention group and 1,038 in the control group), were evaluated in the final analysis...
April 2017: Chinese Journal of Integrative Medicine
https://www.readbyqxmd.com/read/27225292/key-symptoms-selection-for-two-major-syndromes-diagnosis-of-chinese-medicine-in-chronic-hepatitis-b
#18
Yu Zhao, Hong Kang, Jing-Hua Peng, Lin Xu, Zhi-Wei Cao, Yi-Yang Hu
OBJECTIVE: To identify key symptoms of two major syndromes in chronic hepatitis B (CHB), which can be the clinical evidence for Chinese medicine (CM) doctors to make decisions. METHODS: Standardization scales on diagnosis for CHB in CM were designed including physical symptoms, tongue and pulse appearance. The total of 695 CHB cases with dampness-heat (DH) syndrome or Pi (Spleen) deficiency (SD) syndrome were collected for feature selection and modeling, another 275 CHB patients were collected in different locations for validation...
April 2017: Chinese Journal of Integrative Medicine
https://www.readbyqxmd.com/read/26453563/huaiqihuang-granules-reduce-proteinuria-by-enhancing-nephrin-expression-and-regulating-necrosis-factor-%C3%AE%C2%BAb-signaling-pathway-in-adriamycin-induced-nephropathy
#19
Hong Liu, Wei Sun, Liu-Bao Gu, Yue Tu, Bing-Yin Yu, Hao Hu
OBJECTIVE: To investigate the effects of Huaiqihuang Granules (, HQH), a mixture of Chinese herbs including Trametes robiniophila Murr, Fructus Lycii and Polygonatum sibiricum, on adriamycininduced nephropathy (ADRN) in rats and its underlying mechanisms. METHODS: Rats with ADRN were divided into four groups: the sham group, the model group (distilled water), the low-dose HQH-treated (2 g/kg) group, and the high-dose HQH-treated (4 g/kg) group. Body weight and 24-h urinary protein (Upro) were checked every week...
April 2017: Chinese Journal of Integrative Medicine
https://www.readbyqxmd.com/read/25804196/qualitative-analysis-of-a-sulfur-fumigated-chinese-herbal-medicine-by-comprehensive-two-dimensional-gas-chromatography-and-high-resolution-time-of-flight-mass-spectrometry-using-colorized-fuzzy-difference-data-processing
#20
Hao Cai, Gang Cao, Hong-Yan Zhang
OBJECTIVE: To investigate the chemical transformation of volatile compounds in sulfur-fumigated Radix Angelicae Sinensis. METHODS: A comprehensive two-dimensional gas chromatography (GC×GC) and high-resolution time-of-flight mass spectrometry (HR-TOF/MS) with colorized fuzzy difference (CFD) method was used to investigate the effect of sulfur-fumigation on the volatile components from Radix Angelicae Sinensis. RESULTS: Twenty-five compounds that were found in sun-dried samples disappeared in sulfur-fumigated samples...
April 2017: Chinese Journal of Integrative Medicine
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