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Chinese Journal of Integrative Medicine

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https://www.readbyqxmd.com/read/29790065/extract-of-fructus-schisandrae-chinensis-inhibits-neuroinflammation-mediator-production-from-microglia-via-nf-%C3%AE%C2%BA-b-and-mapk-pathways
#1
Fang-Jiao Song, Ke-Wu Zeng, Jin-Feng Chen, Yuan Li, Xiao-Min Song, Peng-Fei Tu, Xue-Mei Wang
OBJECTIVE: To investigate the anti-neuroinflammation effect of extract of Fructus Schisandrae chinensis (EFSC) on lipopolysaccharide (LPS)-induced BV-2 cells and the possible involved mechanisms. METHODS: Primary cortical neurons were isolated from embryonic (E17-18) cortices of Institute of Cancer Research (ICR) mouse fetuses. Primary microglia and astroglia were isolated from the frontal cortices of newborn ICR mouse. Different cells were cultured in specific culture medium...
May 22, 2018: Chinese Journal of Integrative Medicine
https://www.readbyqxmd.com/read/29790064/cohort-study-on-prognosis-of-patients-with-metastatic-colorectal-cancer-treated-with-integrated-chinese-and-western-medicine
#2
Tong Zhang, Wen-Ting He, Ming-Jie Zi, Gang Song, Dan-Hui Yi, Yu-Fei Yang
OBJECTIVE: To investigate the efficacy of integrated Chinese and Western medicine (IM) in the treatment of metastatic colorectal cancer (mCRC) in a cohort study. METHODS: The survival outcome of patients receiving IM was compared with that of patients receiving Western medicine alone. The study design was adopted with "continuous administration of Chinese medicine for ⩾ 3 months" as the exposure factor. Patients who met this exposure factor were assigned to the IM cohort (Group A, 110 patients)...
May 22, 2018: Chinese Journal of Integrative Medicine
https://www.readbyqxmd.com/read/29790063/in-vitro-and-in-vivo-evaluation-of-antitumor-activity-of-ligustrum-robustum-a-chinese-herbal-tea
#3
Hao-Jiang Zuo, Shan Liu, Chun Yan, Li-Man Li, Xiao-Fang Pei
OBJECTIVE: To examine the effect of the aqueous extract of Ligustrum robustum on tumor growth in vitro and in vivo and explore the possible molecular mechanisms. METHODS: In in vitro study, cell viabilities of human cervical carcinoma cells (HeLa), human breast cancer cells (MCF-7), human prostate cancer cells (PC-3), human hepatoma cells (7721) and human colon carcinoma cells (SW480) were evaluated with cell counting kit-8. For L. robustum-treated Hela cells, early or late apoptosis were evaluated by annexin V/PI staining...
May 22, 2018: Chinese Journal of Integrative Medicine
https://www.readbyqxmd.com/read/29790062/analysis-of-pulse-signals-based-on-array-pulse-volume
#4
Ji Cui, Li-Ping Tu, Jian-Feng Zhang, Shao-Liang Zhang, Zhi-Feng Zhang, Jia-Tuo Xu
OBJECTIVE: To collect and analyze multi-dimensional pulse diagram features with the array sensor of a pressure profile system (PPS) and study the characteristic parameters of the new multi-dimensional pulse diagram by pulse diagram analysis technology. METHODS: The pulse signals at the Guan position of left wrist were acquired from 105 volunteers at the Shanghai University of Traditional Chinese Medicine. We obtained the pulse data using an array sensor with 3×4 channels...
May 22, 2018: Chinese Journal of Integrative Medicine
https://www.readbyqxmd.com/read/29752696/total-saponins-of-rubus-parvifolius-l-exhibited-anti-leukemia-effect-in-vivo-through-stat3-and-eif4e-signaling-pathways
#5
Xiao-Feng Xu, Ru-Bin Cheng, Xue-Jin Zhang, Rui-Lan Gao
OBJECTIVE: To investigate the anti-leukemia effect of total saponins of Rubus parvifolius L. (TSRP) on K562 cell xenografts in nude mice and the mechanisms of action. METHODS: The K562 cell xenografts in nude mice were established, and then randomly divided into 5 groups, the control group, the cytosine arabinoside group(Ara-c) and 3 TSRP groups (20, 40 and 100 mg/kg). The tumor volume and mass of each group of nude mice were measured and the anti-tumor rates of TSRP were calculated subsequently...
May 11, 2018: Chinese Journal of Integrative Medicine
https://www.readbyqxmd.com/read/29752695/sodium-tanshinone-ii-a-sulfonate-for-coronary-heart-disease-a-systematic-review-of-randomized-controlled-trials
#6
Mei-Li Yu, Si-Ming Li, Xiang Gao, Jin-Gen Li, Hao Xu, Ke-Ji Chen
OBJECTIVE: To assess whether an adjunctive therapy of Sodium Tanshinone II A Sulfonate Injection (STS) is effective and safe in improving clinical outcomes in patients with coronary heart disease (CHD). METHODS: literature search was conducted through PubMed, the Cochrane Library, Knowledge Infrastructure Databases (CNKI), Chinese Biomedical Literature Database (SinoMed), Chinese Science and Technology Periodical Database (VIP) and Wanfang Database up to August 2017...
May 11, 2018: Chinese Journal of Integrative Medicine
https://www.readbyqxmd.com/read/29752694/ginkgo-leaf-extract-and-dipyridamole-injection-as-adjuvant-treatment-for-angina-pectoris-a-meta-analysis-of-41-randomized-controlled-trials
#7
Di Tan, Jia-Rui Wu, Ying-Ying Cui, Yi Zhao, Dan Zhang, Shi Liu, Bing Zhang
OBJECTIVE: To provide information about the effectiveness and safety of Ginkgo Leaf Extract and Dipyridamole Injection (GD) as one adjuvant therapy for treating angina pectoris (AP) and to evaluate the relevant randomized controlled trials (RCTs) with meta-analysis. METHODS: RCTs concerning AP treated by GD were searched in China Biology Medicine Disc (SinoMed), PubMed, the China National Knowledge Infrastructure Database (CNKI), the Chinese Scientififi c Journals Database (VIP), Wanfang Database, Embase, and the Cochrane Library, from inception to February, 2017...
May 11, 2018: Chinese Journal of Integrative Medicine
https://www.readbyqxmd.com/read/29752693/effects-of-zhizi-chuanxiong-capsule-on-the-abnormal-methylation-in-rabbits-with-atherosclerosis
#8
Qing-Bing Zhou, Li-Qi Wu, Yin Zhang, Zhi-Fang Zhang, Feng-Qin Xu
OBJECTIVE: To investigate the effects of Zhizi Chuanxiong Capsule (ZCC, ) on abnormal DNA methylation in a rabbit model of atherosclerosis (AS). METHODS: After 1 week of adaptive feeding, 48 New Zealand white rabbits were randomly divided into 4 groups: a control group (n=12) fed with normal diet for 22 weeks; a model group (n=12) fed with high fat diet for 14 weeks followed by 8 weeks of normal diet feeding; a low-dose ZCC group (n=12) fed with high fat diet and low-dose ZCC for 14 weeks, followed by 8 weeks of normal diet and low-dose drug; a high-dose ZCC group (n=12) fed with high fat diet and high-dose drug for 14 weeks, followed by 8 weeks of normal diet and high-dose drug...
May 11, 2018: Chinese Journal of Integrative Medicine
https://www.readbyqxmd.com/read/29752692/understanding-and-therapeutic-strategies-of-chinese-medicine-on-gut-derived-uremic-toxins-in-chronic-kidney-disease
#9
Chuan Guo, Xiang-Rong Rao
Chronic kidney disease (CKD) is a major disease that threatens human health. With the progression of CKD, the risk of cardiovascular death increases, which is associated with the elevated levels of uremic toxins (UTs). Representative toxins such as indoxyl sulfate and p-cresyl sulfate are involed in CKD progression and cardiovascular events inseparable from the key role of endothelial dysfunction. The therapeutic strategies of UTs are aimed at signaling pathways that target the levels and damage of toxins in modern medicine...
May 11, 2018: Chinese Journal of Integrative Medicine
https://www.readbyqxmd.com/read/29761313/genomewide-dna-methylation-responses-in-patients-with-%C3%AE-thalassemia-treated-with-yisui-shengxue-granules
#10
Yan-Ling Cheng, Xin-Hua Zhang, Yu-Wen Sun, Wen-Juan Wang, Jie Huang, Na-Li Chu, Su-Ping Fang, Zhi-Kui Wu
OBJECTIVE: To examine the clinical effects of Yisui Shengxue Granules () in the treatment of β-thalassemia and explore its mechanism on DNA methylation levels. METHODS: A randomized placebo-controlled double-blinded trial was conducted. Forty patients with β-thalassemia were recruited and distributed randomly by envelope method into an experimental group and a control group, 20 patients in each group. The patients were given Yisui Shengxue Granules in the experimental group and placebo in the control group (12 g/bag three times a day) during a 3-month intervention...
May 3, 2018: Chinese Journal of Integrative Medicine
https://www.readbyqxmd.com/read/29744785/herb-induced-liver-injury-a-global-concern
#11
Neil Kaplowitz
Chinese medicine and herb medicine though used to treat liver diseases are an important cause of liver injury. Many phytochemicals have the potential to injure the liver, some in a dose-related fashion and more often in an idiosyncratic fashion, meaning occurrence is uncommon to rare in the population using these treatments. As is the case with pharmaceuticals, the phytochemicals are usually tolerated despite either no or mild transient subclinical injury but rarely in some susceptible patients cause moderate to severe liver injury which is likely mediated by the adaptive immune system...
May 3, 2018: Chinese Journal of Integrative Medicine
https://www.readbyqxmd.com/read/29721788/diagnostic-accuracy-of-chinese-medicine-diagnosis-scale-of-phlegm-and-blood-stasis-syndrome-in-coronary-heart-disease-a-study-protocol
#12
Xiao-Qi Liu, Dan-Hong Peng, Yan-Ping Wang, Rong Xie, Xin-Lin Chen, Chun-Quan Yu, Xian-Tao Li
BACKGROUND: Phlegm and blood stasis syndrome (PBSS) is one of the main syndromes in coronary heart disease (CHD). Syndromes of Chinese medicine (CM) are lack of quantitative and easyimplementation diagnosis standards. To quantify and standardize the diagnosis of PBSS, scales are usually applied. OBJECTIVE: To evaluate the diagnostic accuracy of CM diagnosis scale of PBSS in CHD. METHODS: Six hundred patients with stable angina pectoris of CHD, 300 in case group and 300 in control group, will be recruited from 5 hospitals across China...
May 3, 2018: Chinese Journal of Integrative Medicine
https://www.readbyqxmd.com/read/29700764/thoughts-and-approaches-of-integrated-chinese-and-western-medicine-for-the-treatment-of-oligo-astheno-teratozoospermia
#13
Jun Guo
Oligo-astheno-teratozoospermia (OAT) which perplexes doctors and patients due to its complicated etiology, atypical symptoms and poor clinical efficacy, is a general term for the three pathological states of abnormal semen. OAT is the main factor of male infertility. It is also a hot and difficult point in present studies. Empiric drug is the most popular treatment of this disease in the modern medicine. Chinese medicine (CM) is one of the main methods for the treatment of this disease, and it has certain clinical effect...
April 25, 2018: Chinese Journal of Integrative Medicine
https://www.readbyqxmd.com/read/29700763/reliability-accuracy-and-use-frequency-of-evaluation-methods-for-amount-of-tongue-coating
#14
Su-Ryun Kim, Dong-Hyun Nam
OBJECTIVE: To classify the evaluation methods for amount of tongue coating (TC) and investigate their reliability, accuracy, and frequency of use. METHODS: Articles published from 1985 to 2015 were searched for evaluation methods for the amount of TC in PubMed and the Cochrane Library. Only clinical researches were included except protocol articles. The methods were classified according to their characteristics. RESULTS: Finally, 113 articles were selected...
April 25, 2018: Chinese Journal of Integrative Medicine
https://www.readbyqxmd.com/read/29671118/application-of-computer-aided-tongue-inspection-for-preliminary-screening-of-esophageal-cancer
#15
Jin-Long Duan, Bo Deng, Guo-Hui Song, Zhi-Feng Chen, Yan-Wei Gong, Yu-Hua He, Li-Qun Jia
OBJECTIVE: To differentiate patients with esophageal cancer or premalignant lesions from the high-risk population for preliminary screening of esophageal cancer using a feature index determined by a computer-aided tongue information acquisition and processing system (DS01-B). METHODS: Totally, 213 patients diagnosed with esophageal cancer or premalignant lesions and 2,840 normal subjects were collected including primarily screened and reexamined, all of them were confirmed with histological examinations...
April 17, 2018: Chinese Journal of Integrative Medicine
https://www.readbyqxmd.com/read/29667148/sublingual-nodules-diagnostic-markers-of-metastatic-breast-cancer
#16
Xue Yang, Cui-Hong Zhu, Rui Cao, Jian Hao, Xiong-Zhi Wu
OBJECTIVE: To evaluate the diagnostic significance of sublingual nodules for metastasis of patients with breast cancer and further to explore the mechanisms of sublingual nodules. METHODS: The image data of 117 in-patients with breast cancer in stage I-IV in Tianjin Medical University Cancer Institute and Hospital from December 2009 to September 2011 were assessed retrospectively. All photos of patients' tongue were recorded by the digital camera of uniform type within 1 month after serological examination and regular re-examined by computed tomography (CT), magnetic resonance imaging and positron emission tomography CT...
April 17, 2018: Chinese Journal of Integrative Medicine
https://www.readbyqxmd.com/read/29667147/effects-of-heyan-kuntai-capsule-on-follicular-development-and-oocyte-cohesin-levels-in-aged-mice
#17
Bin Zhang, Nan Chu, Xue-Min Qiu, Wei Tang, Hans-Jürgen Gober, Da-Jin Li, Ling Wang
OBJECTIVE: To evaluate the effect of Heyan Kuntai Capsule (, HYKT) on the ovarian function of aged mice and expressions of cohesion complexes in oocytes. METHODS: Twenty-five 9-month-old female C57BL/6J mice were randomly divided into 5 groups by block randomization method (n=5 per group), including the control group (saline), 17 β-estradiol group [E2 , 100 μg/(kg·d)], and low-, medium-, and high-dose of HYKT groups [0.3, 0.9, 2.7 g/(kg·d), respectively]. All mice were treated by intragastric administration for 4 weeks...
April 17, 2018: Chinese Journal of Integrative Medicine
https://www.readbyqxmd.com/read/29651676/essence-of-shen-kidney-controlling-bones-conceptual-analysis-based-on-hypothalamic-pituitary-adrenal-osteo-related-cells-axis
#18
Tao-Tao Xu, Hong-Ting Jin, Pei-Jian Tong
As a traditional concept of Chinese medicine (CM), the theory of "Shen (Kidney) controlling bones" has been gradually proven. And in modern allopathic medicine, the multiple mechanisms of bone growth, development and regeneration align with the theory. Shen defifi ciency as a pathological condition has a negative effect on the skeleton of body, specififi cally the disorder of bone homeostasis. Present studies indicate that Shen defifi ciency shares a common disorder characterized by dysfunction of hypothalamic-pituitary-adrenal (HPA) axis...
April 12, 2018: Chinese Journal of Integrative Medicine
https://www.readbyqxmd.com/read/29651675/tackling-osteoarthritic-knee-pain-with-electroacupuncture
#19
Jun Chen, Xian-Xiang Liu
Electroacupuncture (EA) has been widely used in pain relief. Clinical evidence has revealed its unique advantages and effectiveness in alleviating pain. Studies on EA and pain relief have revealed that EA displays greater analgesic effects for different types of pain in comparison to manual acupuncture. Here, we reviewed the clinical application and mechanism of EA in treating osteoarthritic knee pain and its influence factors in curative effect.
April 12, 2018: Chinese Journal of Integrative Medicine
https://www.readbyqxmd.com/read/29651674/intestinal-microbiota-and-kidney-diseases
#20
Ao Xie, Jie Sheng, Feng Zheng
Kidney diseases are common and the incidence rate is increasing. Gut microbiota is involved in metabolic and immune regulation of the host. Genetic, alimentary and environmental disease factors may change gut flora and increase opportunistic and pathogenic bacteria, contributing to immune or non-immune mediated kidney diseases including IgA nephropathy and diabetic nephropathy. Additionally, bacterial metabolites may be a source of uremic toxins. Thus, identififi cation of diversity, composition, and metabolic and immunologic features of gut bacteria in chronic kidney diseases may help understand pathogenetic mechanism and develop therapy for diseases...
April 12, 2018: Chinese Journal of Integrative Medicine
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