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Chinese Journal of Integrative Medicine

Zhen-Fei Wang, Da-Guang Ma, Ling Wang, Li Feng, Jian-Wei Fu, Ying Li, Dan-Ting Wang, Yong-Feng Jia
OBJECTIVE: To investigate the inhibitory effects of paeoniflorin on migration- and invasion-promoting capacities of gastric cancer associated fibroblasts (GCAFs) and to explore the molecular mechanism underlying the effects. METHODS: Paired gastric normal fifbroblast (GNF) and GCAF cultures were established from resected tissues. GCAFs were treated with control medium, or 2.5, 5 or 10 μg/mL paeoniflorin. Conditioned media were prepared from GNFs, GCAFs, control-treated GCAFs and paeoniflorin-treated GCAFs, and used to culture AGS human gastric cancer cells...
October 25, 2018: Chinese Journal of Integrative Medicine
Yi-Jia Shao, Jun Tao, Bing-Bo Yu, Dan Meng, Xu-Long Yang, Jia-Pan Sun, Yan-Xia Qiu, Xiao-Yu Zhang
OBJECTIVE: To evaluate whether the berberine treatment can improve endothelial repair capacity of early endothelial progenitor cells (EPCs) from prehypertensive subjects through increasing CXC chemokine receptor 4 (CXCR4) signaling. METHODS: EPCs were isolated from prehypertensive and healthy subjects and cultured. In vivo reendothelialization capacity of EPCs from prehypertensive patients with or without in vitro berberine treatment was examined in a nude mouse model of carotid artery injury...
October 19, 2018: Chinese Journal of Integrative Medicine
Rosa Martha Perez Gutierrez, Jose Maria Mota Flores
OBJECTIVE: To examine the effect of metanol extract of Petiveria alliacea (PM) on airway inflammation in a murine model of chronic asthma. METHODS: Two-month-old male BALB/c mice (n=6-8/group) were sensitized on days 0 and 14 by intraperitoneal injection of 20 μg ovalbumin (OVA). On day 25, the mice received an airway challenge with OVA (3%, w/v, in phosphate buffered saline). PM was administered orally by oral gavage to mice at doses of 100, 200 and 400 mg/kg body weight once daily from days 18 to 23...
October 19, 2018: Chinese Journal of Integrative Medicine
Chi Zhang, Li Li, Ge Zhang, Ke-Ji Chen, Ai-Ping Lu
Biological complexity and the need for personalized medicine means that biomarker development has become increasingly challenging. Thus, new paradigms for research need to be created that bring together a different classifier of individuals. One potential solution is collaboration between biomarker development and Chinese medicine pattern classification. In this article, two examples of rheumatoid arthritis are discussed, including a new biomarker candidate casein kinase 2 interacting protein 1 (CKIP-1) and a micro RNA 214...
October 19, 2018: Chinese Journal of Integrative Medicine
Na Wang, Yan Guo
The number of people with chronic diseases rises rapidly in recent years worldwide. Except for drug medication, mind-body exercises are indispensable for chronic disease management. Traditional Chinese practice (TCP), as an integrative intervention, is known as an effective means to keep in good health and fitness, as well as help regulate emotion. This paper introduces the domestic and overseas studies on effectiveness of TCP for chronic diseases, and explores the key action links from three aspects, including functional training of multiple-joint guided by consciousness, relieving psychological risk factors, improving respiratory and digestive function, blood and lymph circulation through respiratory training, and regulation of nerve, metabolic, and immune system...
October 18, 2018: Chinese Journal of Integrative Medicine
Xian-Pei Heng, Xiu-Jun Li, Liang Li, Liu-Qing Yang, Zi-Ta Wang, Su-Ping Huang
Traditional glucose-lowering chemical agents, including various types of insulin and insulin secretagogues, insulin sensitizers, gliptins, etc., are based on diabetic pathogenesis of insulin resistance (IR) and islet insufficiency. Numerous evidence-based medical studies have shown that these traditional hypoglycemic chemical agents do not provide cardiovascular benefit to patients with type 2 diabetes mellitus (T2DM) and may even increase the risk of all-cause mortality. Based on research evidence published to date, these studies show that overload of energy could increase the incidence and prevalence of T2DM, and reduction in the heat load can significantly reduce the incidence of T2DM...
October 17, 2018: Chinese Journal of Integrative Medicine
Shuai Mao, Dan-Ping Xu, Xiao-Jing Dang, Winny Li, Huan-Lin Wu
BACKGROUND: Many patients with chronic angina experience anginal episodes despite successful recanalization, antianginal and antiischemic medications. Empirical observations suggested that Shenzhu Guanxin Recipe Granules (, SGR), a Chinese herbal compound, exerted potential impacts on increased treadmill exercise performance and angina relieve. However, there has been no systematic study to clarify the impact of SGR on exercise tolerance in patients with stable angina. The SERIES (ShEnzhu guanxin Recipe for Improving Exercise tolerance in patients with Stable angina) trial is designed to determine the effects of SGR on exercise duration, electrocardiographic (ECG) evidence of myocardial ischemia, and incidence of major adverse cardiac events (MACE) in stable anginal patients...
October 17, 2018: Chinese Journal of Integrative Medicine
Min Wang, Yan Sun, Shu-Jing Zhang, Yu-Shan Gao, Ya-Nan Wei, Peng-Na Zhao, Miao Liu, Jia-Min Yang, Feng-Jie Zheng, Hong Xu, Yu-Hang Li
OBJECTIVE: To observe the effect of San-Ao Decoction (, SAD) on water metabolism of bronchial asthra model mice. METHODS: Forty-five female BALB/c mice were randomly divided into control, model and SAD groups by a random number table, 15 mice in each group. A composite method with ovalbumin (OVA) sensitization and challenge was developed to establish bronchial asthma model. Mice in the control group were intraperitoneally injected with distilled water without aerosol inhalation challenge...
October 17, 2018: Chinese Journal of Integrative Medicine
Zhao-Hui Jin, Pu Gao, Zheng-Tang Liu, Bing Jin, Guang-Yi Song, Tian-Yuan Xiang
OBJECTIVE: To investigate the effects of Composition of Ophiopogon polysaccharide, Notoginseng total saponins and Rhizoma Coptidis alkaloids (CONR) on myocardial apoptosis of diabetic atherosclerosis (DA) rabbits METHODS: Sixty male New Zealand white rabbits were randomly divided into 6 groups [control group, model group, CONR high-dose group (450 mg/kg), CONR medium-dose group (150 mg/kg), CONR low-dose group (50 mg/kg), and simvastatin group] by using a completely random method, 10 in each group...
October 17, 2018: Chinese Journal of Integrative Medicine
Sang-Hoon Yoon, Yoon-Sik Kim, Hee-Guen Jo, Chan-Young Kwon
OBJECTIVE: To investigate the current usage of terminologies related to acupotomy through systematic search and analyze the pros and cons of each for proposing a standard terminology. METHODS: Seven medical journal databases were searched including PubMed, EMBASE, Cochrane Central Register of Controlled Trials, China National Knowledge Infrastructure, Oriental Medicine Advanced Searching Integrated System, KoreaMed, and Korean studies Information Service System using 10 candidate terminologies as searching terms...
October 17, 2018: Chinese Journal of Integrative Medicine
Yu-Mei Zhou, Yi Zhuang, Ding-Jun Cai, Pei-Ran Lv, Jie Zhou, Min Wan, Yu-Lan Ren, Fan-Rong Liang
OBJECTIVE: To quantify the purine concentrations of the acupoints along the pericardium and nonpericardium meridians under healthy and myocardial ischemia conditions to investigate the relationship between acupoint purine change and body functional status in rats. METHODS: A total of 70 rats underwent an operation for myocardial ischemia, while 40 of them survived. They were randomly assigned to the following 5 subgroups: Neiguan (PC 6), Quze (PC 3), Tianquan (PC 2), Quchi (LI 11), and Jianyu (LI 15)...
September 28, 2018: Chinese Journal of Integrative Medicine
Wei Song, Yong-Wei Zhu
Diabetic retinopathy (DR), a chronic microvascular retinal disorder leading to retinal nonperfusion and ischemia, is one of the leading causes of blindness among individuals of working age. Inflfl ammation and neovascularization play important roles in the development of DR, especially proliferative DR (PDR). Therapies with Chinese medicines (CMs) that improve microcirculation complementary to conventional treatments increase the chances of delaying PDR development and improving visual acuity in diabetes patients...
September 28, 2018: Chinese Journal of Integrative Medicine
Emran Habibi, Mohammad Shokrzadeh, Amirhossein Ahmadi, Aroona Chabra, Farshad Naghshvar, Hamed Haghi-Aminjan, Fatemeh Salehi
OBJECTIVE: To evaluate the protective effect of Zataria multiflora extract, an antioxidative medicinal plant, against cyclophosphamide (CP)-induced oxidative lung damage in mice. METHODS: Mice were intraperitoneally pre-treated with various doses of Zataria multiflora extract (50, 100, 200, and 400 mg/kg) once daily for 7 consecutive days. Animals were then injected with a single 200 mg/kg intraperitoneal dose of CP 1 h after the last administration of O. vulgare...
September 22, 2018: Chinese Journal of Integrative Medicine
Hang-Kun Ma, Yue Liu, Bo Li, Ying Zhang, Lin-Juan Sun, Feng-Qin Xu
OBJECTIVE: To evaluate the efficacy of oral Chinese medicine (CM) in comparison with donepezil, a cholinesterase inhibitor (ChEI), for the treatment of Alzheimer's disease (AD). METHODS: Randomized controlled trials (RCTs) have been searched, and the effect of CM compared with donepezil in AD has been investigated. An electronic search of MEDLINE, Excerpta Medica Database (EMBASE), Cochrane Library, Chinese Biological Medicine Database (CBMdisc), and China National Knowledge Infrastructure (CNKI) to identify articles in English and Chinese from the inception of the database until October 18, 2015...
September 22, 2018: Chinese Journal of Integrative Medicine
Qian-Qian Zhang, Qiang Li, Lin Dong, Wan-Fang Li, Chao Li, Ai-Ping Wang, Jin-Feng Wei, Hong-Tao Jin
OBJECTIVE: To assess the genotoxicity and embryotoxicity of bicyclol methyl ether (BME), the main impurity in bicyclol. METHODS: Five concentrations of BME (0.5, 5, 50, 500 and 5000 μg/plate) were used in the Ames test to detect gene mutation. In the chromosome aberration test, Chinese hamster lung cells were used to detect chromosomal aberration of BME (15, 30, 60, 120 μg/mL) with or without S9 mixture. Embryotoxicity test was also conducted to determine any embryotoxicity of BME (7...
September 22, 2018: Chinese Journal of Integrative Medicine
Yan-Ming Wei, Yong-Hui Wang, Hui-Qing Xue, Zhi-Hua Luan, Bi-Wang Liu, Jin-Hong Ren
As a major active component extracted from traditional Chinese herb Tripterygium wilfordii Hook F, triptolide exhibits multiple pharmacological effects. Autophagy is an evolutionary conserved intracellular catabolic process involved in cytoplasmic materials degradation. Autophagic dysfunction contributes to the pathologies of many human diseases, which makes it a promising therapeutic target. Recent studies have shown that triptolide exerts neuroprotection, anti-tumor activities, organ toxicity, and podocyte protection by modulating autophagy...
September 4, 2018: Chinese Journal of Integrative Medicine
Lan Ma, Jin Dai, Jie Chen, Hong-Wen Cai, Jia-Ying Li, Xin-Yao Li, Shen-Jie Chen, Wei Mao
Angiogenesis in atherosclerotic plaque plays a critical role in the mechanism of atherosclerotic physiopathology. Present consensus shows that angiogenesis in atherosclerotic plaque is mainly resulted in hypoxia, inflammation and some pro-angiogenic factors. The homeostasis in plaque, which is hypoxic and infiltrated by inflammatory cells, may lead to angiogenesis, increase the plaque instability and the incidence rate of vascular events. This article reviews the progression of pathogenetic mechanism, physiopathological significance, relevant detecting technique and corresponding therapeutic methods of Chinese and Western medicine of angiogenesis in atherosclerotic plaque, so as to provide more theoretical basis for atherosclerotic clinical treatment...
September 4, 2018: Chinese Journal of Integrative Medicine
Chang-Zhen Gong, Wei Liu
Although the foundations and evolution of Chinese medicine and Western medicine are very different, an increasing amount of research has revealed that those Eastern medicine principles practiced over thousands of years are confifi rmed by new technologies applied to the basic science of the human body. Recent scientififi c discoveries present enticing opportunities to reconcile Chinese medicine theories with Western biomedicine. Is there a trend toward the convergence of Eastern and Western medicine? Four studies which exemplify the potential for convergence are described in this article...
September 4, 2018: Chinese Journal of Integrative Medicine
Ming-Yi Wen, Fu-Cheng Zhang, Yao-Jun Wang
OBJECTIVE: To evaluate the effect of Zhizhu Kuanzhong Capsules (, ZKC) for functional dyspepsia (FD) through meta-analysis. METHODS: Online databases, including PubMed, EM base, China National Knowledge Infrastructure, Wanfang Data, VIP database and Cochrane Library, were searched for randomized controlled trials (RCTs) of ZKC for FD from the inception to April, 2016. Trials were selected according to inclusion criteria and were evaluated with quality assessment standards in the Cochrane Handbook for Systematic Reviews of Interventions and Jadad scale...
August 30, 2018: Chinese Journal of Integrative Medicine
Min Cheng, Xu-Hua Liang, Qing-Wei Wang, Ya-Ting Deng, Zhi-Xin Zhao, Xue-Ying Liu
OBJECTIVE: To examine the effects of ursolic acid (UA) on mitigating retinoic acid (RA)-induced osteoporosis in rats. METHODS: Fifty female Sprague-Dawley rats were randomly divided into the control group (n=10) and the osteoporosis group (n=40). The 40 osteoporosis rats were induced by 75 mg/(kg•d) RA once daily for 2 weeks, and then were randomly assigned to vehicle control (model), low-, middle-, and high-dose UA [(UA-L, UA-M, UA-H; 30, 60, 120 mg/(kg•d), respectively] groups (10 rats each)...
August 30, 2018: Chinese Journal of Integrative Medicine
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