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Chinese Journal of Integrative Medicine

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https://www.readbyqxmd.com/read/28795389/anti-nociceptive-effect-of-patchouli-alcohol-involving-attenuation-of-cyclooxygenase-2-and-modulation-of-mu-opioid-receptor
#1
Xuan Yu, Xin-Pei Wang, Xiao-Jin Yan, Jing-Fei Jiang, Fan Lei, Dong-Ming Xing, Yue-Ying Guo, Li-Jun Du
OBJECTIVE: To explore the anti-nociceptive effect of patchouli alcohol (PA), the essential oil isolated from Pogostemon cablin (Blanco) Bent, and determine the mechanism in molecular levels. METHODS: The acetic acid-induced writhing test and formalin-induced plantar injection test in mice were employed to confifirm the effect in vivo. Intracellular calcium ion was imaged to verify PA on mu-opioid receptor (MOR). Cyclooxygenase 2 (COX2) and MOR of mouse brain were expressed for determination of PA's target...
August 9, 2017: Chinese Journal of Integrative Medicine
https://www.readbyqxmd.com/read/28795388/brucine-suppresses-breast-cancer-metastasis-via-inhibiting-epithelial-mesenchymal-transition-and-matrix-metalloproteinases-expressions
#2
Miao Li, Ping Li, Mei Zhang, Feng Ma
OBJECTIVE: To examine the effect of brucine on the migration, invasion, adhesion and expressions of epithelial-to-mesenchymal transition (EMT) markers and matrix metalloproteinases (MMPs) in the highly metastatic breast cancer cell lines MDA-MB-231 and Hs578-T. METHODS: MDA-MB-231 and Hs578-T cells were divided to 4 groups: the control group (0.1% DMSO), and 25, 50 and 100 μmol/L brucine groups. The cell viability was determined using a CellTiter-Glo® luminescent cell viability...
August 9, 2017: Chinese Journal of Integrative Medicine
https://www.readbyqxmd.com/read/28795387/gefitinib-plus-fuzheng-kang-ai-formula-in-patients-with-advanced-non-small-cell-lung-cancer-with-epidermal-growth-factor-receptor-mutation-a-randomized-controlled-trial
#3
Xiao-Bing Yang, Xiao-Shu Chai, Wan-Yin Wu, Shun-Qin Long, Hong Deng, Zong-Qi Pan, Wen-Feng He, Yu-Shu Zhou, Gui-Ya Liao, Shu-Jing Xiao
OBJECTIVE: To evaluate the effect of Fuzheng Kang'ai Formula (, FZKA) plus gefitinib in patients with advanced non-small cell lung cancer with epidermal growth factor receptor (EGFR) mutations. METHODS: A randomized controlled trial was conducted from 2009 to 2012 in South China. Seventy chemotherapynaive patients diagnosed with stage IIIB/IV non-small cell lung cancer with EGFR mutations were randomly assigned to GF group [gefifitinib (250 mg/day orally) plus FZKA (250 mL, twice per day, orally); 35 cases] or G group (gefifitinib 250 mg/day orally; 35 cases) according to the random number table and received treatment until progression of the disease, or development of unacceptable toxicities...
August 9, 2017: Chinese Journal of Integrative Medicine
https://www.readbyqxmd.com/read/28762132/electro-acupuncture-at-governor-vessel-improves-neurological-function-in-rats-with-spinal-cord-injury
#4
Wen-Zhan Tu, Song-He Jiang, Li Zhang, Si-Si Li, Peng-Peng Gu, Rong He, Jie Hu, Li-Ping Gao, Qiang-San Sun
OBJECTIVE: To determine the effects of electro-acupuncture (EA) at Governor Vessel (GV) on the locomotor function in spinal cord injury (SCI) rats and explore the underlying mechanism. METHODS: Thirtytwo male Sprague-Dawley rats were randomly divided into four groups namely: the sham group (with sham operation); the untreated group (without treatment after spinal cord impact); the EA-1 group [EA applied at Baihui (GV 20) and Fengfu (GV 16) after spinal cord impact] and the EA-2 group [with EA applied at Dazhui (GV 14) and Mingmen (GV 4) after spinal cord impact]...
July 31, 2017: Chinese Journal of Integrative Medicine
https://www.readbyqxmd.com/read/28762131/schizandra-chinensis-exhibits-phytoestrogenic-effects-by-regulating-the-activation-of-estrogen-receptor-%C3%AE-and-%C3%AE
#5
Mi Hye Kim, Hyoun-Su Lee, Seong Bin Hong, Woong Mo Yang
OBJECTIVE: To investigate the phytoestrogenic effects of Schizandra chinensis (SC) extract by regulating the activation of estrogen receptor. METHODS: Western blotting assay was performed to investigate the effect of SC extract (1, 10, 100 μg/mL) on the expression of estrogen receptor (ER)-α and -β in MCF-7 human breast cancer cells. Cell viability and the levels of c-fos and c-Jun were analyzed by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay and Western blot analysis, respectively, to further confirm the anti-cancer effect of SC extract...
July 31, 2017: Chinese Journal of Integrative Medicine
https://www.readbyqxmd.com/read/28755078/weaker-cognitive-control-abilities-of-pi-spleen-qi-deficient-individuals-supported-chinese-medicine-diagnosis
#6
Hui-Yan Lin, Yan-Ping Zhao, Gui-Ping Xu, Yun-Si Li, Wei-Yun Xie, Li-Hua Bai, Hua Jin
OBJECTIVE: To investigate whether Pi (Spleen) qi-deficiency affected psychological and neural responses in relevance to cognitive control. METHODS: Pi qi-deficient and balanced participants were asked to perform the Stroop task, a classical cognitive control paradigm. In this paradigm, participants had to judge the color of the prompted word. The word's meaning indicated the color (the consistent condition) or not (the inconsistent condition), or were unrelated to the color (the neutral condition)...
July 28, 2017: Chinese Journal of Integrative Medicine
https://www.readbyqxmd.com/read/28755077/processing-of-calamine-with-modern-analytical-techniques-processed-with-huanglian-decoction-and-sanhuang-decoction
#7
Xiang-Long Meng, Jun-Nan Ma, Xiao-Hui Guo, Bing-Chen Liu, Nan-Nan Cui, Kun Li, Shuo-Sheng Zhang
OBJECTIVE: To determine the pyrolysis characteristics of calcined and processed calamine, qualitatively and quantitatively compare the contents of related elements, morphology and functional groups of the pyrolysis products dried at different heating temperatures and explore the critical temperature and the optimal drying temperature for the process of calamine with Huanglian Decoction (HLD, ) and San Huang Decoction (SHD, ). METHODS: Pyrolysis products were prepared by programmable and constantly heating the calcined and processed calamine to or at different heating temperatures...
July 28, 2017: Chinese Journal of Integrative Medicine
https://www.readbyqxmd.com/read/28755076/comparative-pharmacokinetics-of-three-phenylpropanoids-in-rat-plasma-after-oral-administration-of-ramulus-cinnamomi-and-ramulus-cinnamomi-ephedrae-herba-herb-couple-extract
#8
Ping Wei, Qing-Fa Tang, Hui-Ling Huo, Fei-Long Chen, Shuai Song, Xue-Feng Xing, Jia-Bo Luo
OBJECTIVE: To investigate the pharmacokinetic characteristics of three phenylpropanoids (cinnamic acid, cinnamic alcohol and coumarin) in Ramulus Cinnamomi (GZ) and Ramulus Cinnamomi-Ephedrae Herba (MH) herb-couple (GZMH). METHODS: Twelve male Sprague-Dawley rats were randomly and equally divided into the GZ and GZMH herb-couple groups. Blood samples were collected at 0, 0.08, 0.25, 0.5, 0.75, 1.5, 3, 4, 6, 8, 12, 24, 36 and 48 h after oral administration. The three phenylpropanoids in rat plasma were quantified using an ultra-performance liquid-chromatography with tandem mass spectrometry (UPLC-MS/MS) method for pharmacokinetic study...
July 28, 2017: Chinese Journal of Integrative Medicine
https://www.readbyqxmd.com/read/28741063/effects-of-astragalus-polysaccharide-on-mechanical-characterization-of-liver-sinusoidal-endothelial-cells-by-atomic-force-microscopy-at-nanoscale
#9
Wen-Liang Lu, Juan-Mei Li, Jiao Yang, Chen-Guang Xu, Sha-Sha Zhang, Jie Yan, Ting-Ting Zhang, Hui-Hui Zhao
OBJECTIVE: To study the effects of Astragalus polysaccharide (APS), the primary effective component of the Chinese herb medicine Astragalus membranaceus (frequently used for its anti-hepatic fibrosis effects), on nanoscale mechanical properties of liver sinusoidal endothelial cells (SECs). METHODS: Using endothelial cell medium as the control, 5 experimental groups were established utilizing different concentrations of APS, i.e. 12.5, 25, 50, 100, and 200 μg/mL...
July 25, 2017: Chinese Journal of Integrative Medicine
https://www.readbyqxmd.com/read/28741062/ethanol-extract-of-ilex-hainanensis-merr-exhibits-anti-melanoma-activity-by-induction-of-g1-s-cell-cycle-arrest-and-apoptosis
#10
Ya-Qi Zhang, Hao Yang, Wei-Dong Sun, Juan Wang, Bao-Yuan Zhang, Yan-Jun Shen, Min-Qiang Yin, Yun-Xing Liu, Chang Liu, Yun Sun
OBJECTIVE: To evaluate anti-melanoma effect of ethanol extract of Ilex hainanensis Merr. (IME) and elucidate its underlying mechanism. METHODS: Thirty-six tumor-bearing mice were randomized into 6 groups (n=6) as follows: model group, IME 25, 50, 100, and 200 mg/kg groups and dacarbazine (DTIC) 70 mg/kg group. The mice in the IME treatment groups were intragastrically administered with IME 25, 50, 100 or 200 mg/kg per day, respectively. The mice in the DTIC group were intraperitoneally injected with DTIC 70 mg/kg every 2 days...
July 25, 2017: Chinese Journal of Integrative Medicine
https://www.readbyqxmd.com/read/28741061/treatment-of-uncomplicated-recurrent-urinary-tract-infection-with-chinese-medicine-formula-a-randomized-controlled-trial
#11
Shi-Wei Liu, Jie Guo, Wei-Kang Wu, Ze-Liang Chen, Ning Zhang
OBJECTIVE: To evaluate Chinese medicine (CM) formula Bazheng Powder () as an alternative therapeutic option for female patients with recurrent urinary tract infection (RUTI). METHODS: A randomized double-blinded trial was performed. Eligible female patients with RUTI were recruited from one hospital and two community health centers. By using a blocked randomization scheme, participants were randomized to receive a CM formula (10 herbs) for 4 weeks or antibiotics for 1 week, followed by 3 weeks of placebo...
July 25, 2017: Chinese Journal of Integrative Medicine
https://www.readbyqxmd.com/read/28741060/efficacy-of-modified-wuzhuyu-decoction-granule-for-migraine-patients-with-cold-and-stasis-obstructing-meridian-syndrome-a-randomized-double-blind-placebo-controlled-trial
#12
Hong-Wei Liu, Yi-Huai Zou, Ke-Gang Cao, Li-Hua Yu, Yong Zhang, Cai-Hong Fu, Da-Yong Ma
OBJECTIVE: To study the efficacy of modified Wuzhuyu Decoction Granule (, MWDG) in the treatment of migraine patients with cold and stasis obstructing meridian syndrome. METHODS: This study was a randomized, double-blind, placebo-controlled trial. A total of 78 migraine patients with cold and stasis obstructing meridian syndrome were recruited and randomly assigned by a ratio of 2:1 into a treatment group (51 cases) and a placebo group (27 cases). Patients in the treatment group were treated with MWDG while placebo granules were applied in the control group...
July 25, 2017: Chinese Journal of Integrative Medicine
https://www.readbyqxmd.com/read/28634864/diagnostic-indicators-for-blood-stasis-syndrome-patients-with-gynaecological-diseases
#13
Jeeyoun Jung, Mi Mi Ko, Myeong Soo Lee, So Min Lee, Ju Ah Lee
OBJECTIVE: To investigate the important diagnostic indicators for blood stasis syndrome (BSS) in patients of childbearing age with gynaecological diseases. METHODS: A partial least squared-discriminant analysis (PLS-DA) were applied to BSS symptoms data of patients with gynaecological diseases, and the diagnostic indicators used by doctors of Korean medicine (DKMs) among BSS patients with gynaecological diseases were also investigated. RESULTS: A total of 103 patients of childbearing age with gynaecological diseases and 40 healthy controls were enrolled...
June 20, 2017: Chinese Journal of Integrative Medicine
https://www.readbyqxmd.com/read/28634863/high-tech-acupuncture-for-prevention-of-lifestyle-diseases-a-sino-austrian-cooperation-research-protocol-on-heart-rate-variability
#14
Feng-Xia Liang, Ze-Bin Chen, Song Wu, Jian-Min Liu, Jing-Zhi Wang, Ji-Dong Lu, Lu-Shan Wang, Li Chen, Qing Shu, Daniela Litscher, Lu Wang, Hua Wang, Gerhard Litscher
BACKGROUND: Acupuncture can not only be used for well-known diseases, but also for so-called modern lifestyle-related diseases. Using innovative methods like e.g. new analyses of heart rate variability (HRV), it is also possible to investigate diseases like burnout syndrome, ie., qi defificiency in Chinese medicine (CM). OBJECTIVE: The main object of this research protocol is to perform research on the relationship of burnout syndrome and heart rate (HR) and HRV...
June 20, 2017: Chinese Journal of Integrative Medicine
https://www.readbyqxmd.com/read/28578487/gambogic-acid-induces-cell-apoptosis-and-inhibits-mapk-pathway-in-pten-p53-prostate-cancer-cells-in-vitro-and-ex-vivo
#15
Hong Pan, Li-Yuan Lu, Xue-Qian Wang, Bin-Xue Li, Kathleen Kelly, Hong-Sheng Lin
OBJECTIVE: To investigate the effect of gambogic acid (GA) on the growth and cell death of castrate resistant prostate cancer (PC) with phosphate and tension homology (PTEN) and p53 genes deleted in vitro and ex vivo, and elucidate the underlying possible molecular mechanisms. METHODS: PTEN(-/-)/p53(-/-) PC cells and Los Angeles prostate cancer-4 (LAPC-4) cells were treated with GA for 24 h and 48 h, then cell viability was determined by cell proliferation assay...
June 3, 2017: Chinese Journal of Integrative Medicine
https://www.readbyqxmd.com/read/28578486/angelica-tenuissima-nakai-ameliorates-cognitive-impairment-and-promotes-neurogenesis-in-mouse-model-of-alzheimer-s-disease
#16
Minji Choi, Younghyurk Lee, Seung-Hun Cho
OBJECTIVE: To research Angelica tenuissima Nakai (ATN) for use in novel Alzheimer's disease (AD) therapeutics. METHODS: The effect of a 30% ethanol extract of ATN (KH032) on AD-like cognitive impairment and neuropathological and neuroinflammatory changes induced by bilateral intracerebroventricular injections of β-amyloid (Aβ) peptide (Aβ1-42) was investigated. Male C57Bl/6 mice were randomly divided into 4 groups, 10 in each group. KH032-treated groups were administrated with a low or high dose of KH032 (50 and 200 mg/kg, respectively), intragastrically for 16 days; distilled water was applied in the sham and negative groups...
June 3, 2017: Chinese Journal of Integrative Medicine
https://www.readbyqxmd.com/read/28578485/thoughts-on-the-importance-of-government-regulated-chinese-medicine-terminology-standardization
#17
Ioannis Solos, Mei Hong, Jie Ding, Jian-Ping Zhu, Li-Guo Chen
The applications of a standardized Chinese medicine (CM) terminology are ultimately the translation and publication of literature, education, as well as scholarly and legal communication. Over the past 20-30 years the amount of published CM literature, including clinical and experimental research, has increased exponentially. In addition, the numbers of professionally trained Western CM scholars and clinicians have been continuously rising, and they are now forming a considerable academic force that should be taken seriously...
June 3, 2017: Chinese Journal of Integrative Medicine
https://www.readbyqxmd.com/read/28664246/babaodan-capsule-combined-with-qingyi-huaji-formula-in-advanced-pancreatic-cancer-a-feasibility-study
#18
Li-Bin Song, Song Gao, Ai-Qin Zhang, Xiang Qian, Lu-Ming Liu
OBJECTIVE: To observe the clinical effects of Babaodan Capsule (, BBD) combined with Qingyi Huaji Formula (, QYHJ) in treating patients with advanced pancreatic cancer. METHODS: Eighty-one patients with advanced pancreatic cancer (from January 1, 2013 to December 31, 2014) were enrolled. Patients were assigned to two groups randomly with a random number table: QYHJ plus BBD group (40 cases) and QYHJ only group (41 cases), and there were no significant differences for other treatment between two groups...
May 27, 2017: Chinese Journal of Integrative Medicine
https://www.readbyqxmd.com/read/28551771/synergistic-effects-of-chuanxiong-chishao-herb-pair-on-promoting-angiogenesis-at-network-pharmacological-and-pharmacodynamic-levels
#19
Yan Wang, Gang Guo, Bin-Rui Yang, Qi-Qi Xin, Qi-Wen Liao, Simon Ming-Yuen Lee, Yuan-Jia Hu, Ke-Ji Chen, Wei-Hong Cong
OBJECTIVE: To investigate the synergistic effects of Chuanxiong-Chishao herb-pair (CCHP) on promoting angiogenesis in silico and in vivo. METHODS: The mechanisms of action of an herb-pair, Chuanxiong- Chishao, were investigated using the network pharmacological and pharmacodynamic strategies involving computational drug target prediction and network analysis, and experimental validation. A set of network pharmacology methods were created to study the herbs in the context of targets and diseases networks, including prediction of target profiles and pharmacological actions of main active compounds in Chuanxiong and Chishao...
May 27, 2017: Chinese Journal of Integrative Medicine
https://www.readbyqxmd.com/read/28762174/ethnic-chinese-medicine-borderless-civilization-on-the-identity-of-humane-and-scientific-nature-of-chinese-and-western-medicines
#20
Ke-Ji Chen
No abstract text is available yet for this article.
August 2017: Chinese Journal of Integrative Medicine
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