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Chinese Journal of Integrative Medicine

Yan-Ming Wei, Yong-Hui Wang, Hui-Qing Xue, Zhi-Hua Luan, Bi-Wang Liu, Jin-Hong Ren
As a major active component extracted from traditional Chinese herb Tripterygium wilfordii Hook F, triptolide exhibits multiple pharmacological effects. Autophagy is an evolutionary conserved intracellular catabolic process involved in cytoplasmic materials degradation. Autophagic dysfunction contributes to the pathologies of many human diseases, which makes it a promising therapeutic target. Recent studies have shown that triptolide exerts neuroprotection, anti-tumor activities, organ toxicity, and podocyte protection by modulating autophagy...
September 4, 2018: Chinese Journal of Integrative Medicine
Lan Ma, Jin Dai, Jie Chen, Hong-Wen Cai, Jia-Ying Li, Xin-Yao Li, Shen-Jie Chen, Wei Mao
Angiogenesis in atherosclerotic plaque plays a critical role in the mechanism of atherosclerotic physiopathology. Present consensus shows that angiogenesis in atherosclerotic plaque is mainly resulted in hypoxia, inflammation and some pro-angiogenic factors. The homeostasis in plaque, which is hypoxic and infiltrated by inflammatory cells, may lead to angiogenesis, increase the plaque instability and the incidence rate of vascular events. This article reviews the progression of pathogenetic mechanism, physiopathological significance, relevant detecting technique and corresponding therapeutic methods of Chinese and Western medicine of angiogenesis in atherosclerotic plaque, so as to provide more theoretical basis for atherosclerotic clinical treatment...
September 4, 2018: Chinese Journal of Integrative Medicine
Chang-Zhen Gong, Wei Liu
Although the foundations and evolution of Chinese medicine and Western medicine are very different, an increasing amount of research has revealed that those Eastern medicine principles practiced over thousands of years are confifi rmed by new technologies applied to the basic science of the human body. Recent scientififi c discoveries present enticing opportunities to reconcile Chinese medicine theories with Western biomedicine. Is there a trend toward the convergence of Eastern and Western medicine? Four studies which exemplify the potential for convergence are described in this article...
September 4, 2018: Chinese Journal of Integrative Medicine
Ming-Yi Wen, Fu-Cheng Zhang, Yao-Jun Wang
OBJECTIVE: To evaluate the effect of Zhizhu Kuanzhong Capsules (, ZKC) for functional dyspepsia (FD) through meta-analysis. METHODS: Online databases, including PubMed, EM base, China National Knowledge Infrastructure, Wanfang Data, VIP database and Cochrane Library, were searched for randomized controlled trials (RCTs) of ZKC for FD from the inception to April, 2016. Trials were selected according to inclusion criteria and were evaluated with quality assessment standards in the Cochrane Handbook for Systematic Reviews of Interventions and Jadad scale...
August 30, 2018: Chinese Journal of Integrative Medicine
Min Cheng, Xu-Hua Liang, Qing-Wei Wang, Ya-Ting Deng, Zhi-Xin Zhao, Xue-Ying Liu
OBJECTIVE: To examine the effects of ursolic acid (UA) on mitigating retinoic acid (RA)-induced osteoporosis in rats. METHODS: Fifty female Sprague-Dawley rats were randomly divided into the control group (n=10) and the osteoporosis group (n=40). The 40 osteoporosis rats were induced by 75 mg/(kg•d) RA once daily for 2 weeks, and then were randomly assigned to vehicle control (model), low-, middle-, and high-dose UA [(UA-L, UA-M, UA-H; 30, 60, 120 mg/(kg•d), respectively] groups (10 rats each)...
August 30, 2018: Chinese Journal of Integrative Medicine
Chao-Chao Yu, Chao-Yang Ma, Hua Wang, Li-Hong Kong, Yan Zhao, Feng Shen, Miao Wu
As the worldwide population ages, the prevalence of Alzheimer's disease (AD) increases. However, the results of promising medications have been unsatisfactory. Chinese acupuncture has a long history of treating dementia, but lack of evidence from well-designed randomized controlled trials that validate its efficacy and safety, as well as its lack of clear underlying mechanisms, contribute to its limited application in clinical practice. In recent years, brain imaging technologies, such as functional magnetic resonance imaging and positron emission tomography, have been used to assess brain responses to acupuncture in a dynamic, visual, and objective way...
August 28, 2018: Chinese Journal of Integrative Medicine
Yang Cheng, Ping Liu, Tian-Lu Hou, Maerbiya Maimaitisidike, Reyangguli Ababaikeli, Aini Abudureyimu
OBJECTIVE: To explore the action mechanisms of Huangqi Decoction Granules (, HQDG) on hepatitis B cirrhosis. METHODS: A total of 85 patients with hepatitis B cirrhosis were randomly divided into HQDG group (42 cases) and control group (43 cases) by a random number table and were treated with HQDG or placebo for 48 weeks (6 g per times and orally for 3 times a day), respectively. After RNA-sequencing of serum samples extracted from the patients, the differentially expressed genes (DEGs) in HQDG and control groups before and after treatment were separately screened...
August 28, 2018: Chinese Journal of Integrative Medicine
Rui-Xiang Zeng, Mao-Sheng Chen, Min-Zhou Zhang
No abstract text is available yet for this article.
August 28, 2018: Chinese Journal of Integrative Medicine
Si-Ming Li, Jin-Gen Li, Hao Xu
Inflammation, which plays a critical role in atherosclerosis and the occurrence of acute cardiovascular events, may be a new target for treatment of coronary artery disease (CAD) to reduce residual cardiovascular risk. Recently, Antiinflammatory Therapy with Canakinumab for Atherosclerotic Disease (CANTOS), the largest scale clinical trial that targeted inflammation but not lipids, has affirmed for the first time the inflammatory hypothesis of artherosclerosis and marked the advent of an exciting era of targeting inflammation for the prevention and treatment of cardiovascular diseases...
August 22, 2018: Chinese Journal of Integrative Medicine
Xi Chen, Fei Qi, A-Ling Shen, Jian-Feng Chu, Thomas Joseph Sferra, You-Qin Chen, Jun Peng
OBJECTIVE: To evaluate the effect of Pien Tze Huang (, PZH) on breast cancer chemoresistance and related epithelial-mesenchymal transition (EMT) and investigate the underlying mechanisms. METHODS: 3-(4,5-Dimethyl-2-thiazolyl)-2,5-diphenyl-2-H-tetrazolium bromide (MTT) assay was used to determine the cell viability. Adriamycin (ADR) staining observed by fluorescence microscope was performed to detect the accumulation of ADR. Transwell assay was used to analyze the cell migration and invasion...
August 22, 2018: Chinese Journal of Integrative Medicine
Chung-Wah Cheng, Li Zhang, Chen Zhao, Linda Ld Zhong, Li-Jie Shi, Liang Dai, Rui Zheng, Jing Chen, Ge Li, Jing-Bo Zhai, Wai Kun, Ai-Ping Lu, Hong-Cai Shang, Zhao-Xiang Bian
BACKGROUND: Syndrome is one of the most important concepts in Chinese medicine (CM) theory. However, it was not well accounted in most of randomized controlled trials (RCTs). OBJECTIVE: To determine whether CM syndrome differentiation affects the treatment results, functional constipation (FC) was selected as a target disease, and MaZiRenWan (, MZRW), a classic CM formula commonly used for constipation with excessive heat syndrome, was selected for study. METHODS: It is an 18-week prospective double-blinded, doubledummy RCT, including 2-week run-in, 8-week treatment and 8-week post treatment follow-up...
August 14, 2018: Chinese Journal of Integrative Medicine
Yang Yang, Jian-Ping Liu, Jun-Yan Fang, Hui-Chan Wang, Yun Wei, Yu Cao, Jian-Gang Liu, Long-Tao Liu, Hao Li
OBJECTIVE: To assess the effect and safety of Huannao Yicong Formula (, HYF) in the treatment of patients with mild-to-moderate Alzheimer's disease (AD). METHODS: Sixty patients with mild-tomoderate AD were evenly randomized into HYF group and donepezil group with the random number method. Patients in the HYF group took 5 g of HYF granules twice daily and 5 mg placebo of donepezil once daily. Patients in the donepezil group took 5 mg donepezil once daily and 5 g placebo of HYF granules twice daily...
August 14, 2018: Chinese Journal of Integrative Medicine
Ji Hye Hwang, Vinoth R Kumar, Seok Yong Kang, Hyo Won Jung, Yong-Ki Park
OBJECTIVE: To investigate the effects of the flower buds extract of Tussilago farfara Linné (Farfarae Flos; FF) on focal cerebral ischemia through regulation of inflammatory responses in activated microglia. METHODS: Brain ischemia was induced in Sprague-Dawley rats by a transient middle cerebral artery occlusion (tMCAO) for 90 min and reperfusion for 24 h. Twenty rats were randomly divided into 4 groups (n=5 per group): normal, tMCAO-induced ischemic control, tMCAO plus FF extract 300 mg/kg-treated, and tMCAO plus MK-801 1 mg/kg-treated as reference drug...
August 8, 2018: Chinese Journal of Integrative Medicine
Shu-Min Liu, Xu-Zhao Li, Shuai-Nan Zhang, Zhi-Ming Yang, Ke-Xin Wang, Fang Lu, Chong-Zhi Wang, Chun-Su Yuan
OBJECTIVE: To investigate the neuro-protective effects of Acanthopanax senticosus Harms (EAS) on mesencephalic mitochondria and the mechanism of action, using a mouse model of Parkinson's disease (PD). METHODS: The chemical fingerprint analysis of the extract of Acanthopanax senticosus Harms (EAS) was performed using the ultra performance liquid chromatograph and time of flight mass spectrometry. Thirty mice were randomly divided into the control group, the MPTP model group, and the EAS treated group with MPTP (MPTP+EAS group, 10 in each group)...
August 8, 2018: Chinese Journal of Integrative Medicine
Xing Zhang, Nan Peng, Ming-Wei Yu, Gan-Lin Zhang, Xu Sun, Guo-Wang Yang, Chen Li, Lin Yang, Xiao-Min Wang
OBJECTIVE: To assess the effectiveness of Yishen Jiangu Granules (, YSJGG) on aromatase inhibitor-associated musculoskeletal symptoms (AIMSS). METHODS: A single-arm, open-label study was conducted in 34 postmenopausal women with breast cancer who experienced AIMSS. Patients were treated with YSJGG for 12 weeks (12.4 g orally twice daily). The primary outcome was a change in the mean worst pain score of Brief Pain Inventory-Short Form (BPI-SF) over 12 weeks, and the second outcomes included changes in pain severity and pain-related interference of BPI-SF and Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC), Modified Score for the Assessment of Chronic Rheumatoid Affections of the Hands (M-SACRAH), the Functional Assessment of Cancer Therapy-Breast (FACT-B), bone mineral density (BMD) and blood indices such as calcium (Ca), phosphate (P), and alkaline phosphatase (ALP)...
July 31, 2018: Chinese Journal of Integrative Medicine
Wei Gao, Na Li, Xiao-Guang Cui
OBJECTIVE: To evaluate the efficacy of Xuebijing Injection (, XBJ) on the lung injury induced by cardiopulmonary bypass (CPB). METHODS: Fifty patients undergoing CPB were randomized to either the saline group or XBJ group according to a random number table (25 cases in each group). The patients in the saline group received saline and patients in XBJ group received XBJ at 12 h prior to the operation, at the beginning of the operation, and at 12 h after the second injection...
July 31, 2018: Chinese Journal of Integrative Medicine
Jun-Ping Wei, Qiu-Hong Wang, Hui-Juan Zheng, Fan Wei
Type 2 diabetes mellitus (T2DM) is one of the common endocrinology diseases that greatly affects the health care sector and economy. Application of hypoglycemic drugs has its own drawbacks and the use of non-drug therapy on treating T2DM has drawn much attention recently. This paper reviewed the research development of the non-pharmacological interventions on T2DM in recent years, including dietary therapy, exercise therapy, psychotherapy, acupuncture and moxibustion therapies and so on. The authors mentioned the problems in the research of non-drug treatment for blood glucose control of T2DM and put forward new ideas for the research in the future...
July 25, 2018: Chinese Journal of Integrative Medicine
Ya-Yun Qian, You-Yang Shi, Song-Hua Lu, Ting Yang, Xue-Yu Zhao, Yan Yan, Wen-Yuan Li, Yan-Qing Liu
OBJECTIVE: To evaluate the effects of Celastrus Orbiculatus extracts (COE) on metastasis in hypoxia-induced hepatocellular carcinoma cells (HepG2) and to explore the underlying molecular mechanisms. METHODS: The effect of COE (160, 200 and 240 μg/mL) on cell viability, scratch-wound, invasion and migration were studied by 3-4,5-dimethyl-2-thiazolyl-2,5-diphenyl-2-H-tetrazolium bromide (MTT), scratch-wound and transwell assays, respectively. CoCl2 was used to establish a hypoxia model in vitro...
July 25, 2018: Chinese Journal of Integrative Medicine
Sheng-Nan Dai, Ai-Jie Hou, Shu-Mei Zhao, Xiao-Ming Chen, Hua-Ting Huang, Bo-Han Chen, Hong-Liang Kong
OBJECTIVE: To investigate whether ginsenoside-Rb1 (Gs-Rb1) improves the CoCl-induced autophagy of cardiomyocytes via upregulation of adenosine 5'-monophosphate-activated protein kinase (AMPK) pathway. METHODS: Ventricles from 1- to 3-day-old Wistar rats were sequentially digested, separated and incubated in Dulbecco's modified Eagle's medium supplemented with 10% fetal bovine serum for 3 days followed by synchronization. Neonatal rat cardiomyocytes were randomly divided into 7 groups: control group (normal level oxygen), hypoxia group (500 μmol/L CoCl2 ), Gs-Rb1 group (200 μmol/L Gs-Rb1 + 500 μmol/L CoCl2 ), Ara A group (500 μmol/L Ara A + 500 μmol/L CoCl2 ), Ara A+ Gs-Rb1 group (500 μmol/L Ara A + 200 μmol/L Gs-Rb1 + 500 μmol/L CoCl2 ), AICAR group [1 mmol/L 5-aminoimidazole-4-carboxamide ribonucleotide (AICAR) + 500 μmol/L CoCl2 ], and AICAR+Gs-Rb1 group (1 mmol/L AICAR + 200 μmol/L Gs-Rb1 + 500 μmol/L CoCl2 )...
July 18, 2018: Chinese Journal of Integrative Medicine
Xiao-Fei Wu, Ya-Juan Yu, Ling-Mei Ying, Wei-Fen Tan, Xiao-Yan Zhan, Ling-Cong Wang
OBJECTIVE: To explore the preventive effect of applying hot compress with Chinese herbal salt packets (CHSP) to puncture vessels under aseptic conditions during peripherally inserted central catheter (PICC) on postoperative phlebitis. METHODS: A total of 720 hospitalized patients undergoing first PICC were assigned to treatment and control groups (360 cases each group) according to a random number table. The control group received conventional catheterization and nursing care...
June 27, 2018: Chinese Journal of Integrative Medicine
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