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Chinese Journal of Integrative Medicine

Xiao-Ming Wang, Wen-Jie Xu, Liang-Kui Xu, Shuai Song, Xue-Feng Xing, Jia-Bo Luo
OBJECTIVE: To investigate the antipyretic mechanism of Herba Ephedrae (Eph)-Ramulus Cinnamomi (RC) herb pair on yeast-induced pyrexia in rats. METHODS: Totally 30 qualifified male SD rats were randomly assigned to the normal control (NC) group, the pyrexia model (model) group, the Eph, RC and Eph-RC treatment groups by a random digital table, 6 rats in each group. Each rat received a 20% aqueous suspension of yeast (10 mL/kg) except the NC group. The 3 treatment groups were administered 8...
January 9, 2018: Chinese Journal of Integrative Medicine
Zi-Gang Zhang, Xin Wang, Jin-Hai Zai, Cai-Hua Sun, Bing-Chun Yan
OBJECTIVE: To examine the effect of icariin (ICA) on the cognitive impairment induced by traumatic brain injury (TBI) in mice and the underlying mechanisms related to changes in hippocampal acetylation level. METHODS: The modifified free-fall method was used to establish the TBI mouse model. Mice with post-TBI cognitive impairment were randomly divided into 3 groups using the randomised block method (n=7): TBI (vehicle-treated), low-dose (75 mg/kg) and high-dose (150 mg/kg) of ICA groups...
January 9, 2018: Chinese Journal of Integrative Medicine
Hu-Qing Wang, Meng Zhang, Jia-Xin Zhao, Hai-Qin Wu, Zhen Gao, Gui-Lian Zhang, Ru Zhang
OBJECTIVE: To observe the effect of puerarin on methyl-CpG binding protein 2 (MeCP2) phosphorylation (pMeCP2) in the hippocampus of a rat model of vascular dementia (VD). METHODS: Thirty-six healthy Sprague-Dawley rats were randomly assigned to the sham-operated group, dementia group and puerarintreated group using a random number table (n=12 per group). The modifified permanent bilateral common carotid artery occlusion method was used to establish the VD model...
January 9, 2018: Chinese Journal of Integrative Medicine
Ning Zhao, Guang Zheng, Jian Li, Hong-Yan Zhao, Cheng Lu, Miao Jiang, Chi Zhang, Hong-Tao Guo, Ai-Ping Lu
OBJECTIVE: To identify the commonalities between rheumatoid arthritis (RA) and diabetes mellitus (DM) to understand the mechanisms of Chinese medicine (CM) in different diseases with the same treatment. METHODS: A text mining approach was adopted to analyze the commonalities between RA and DM according to CM and biological elements. The major commonalities were subsequently verifified in RA and DM rat models, in which herbal formula for the treatment of both RA and DM identifified via text mining was used as the intervention...
January 9, 2018: Chinese Journal of Integrative Medicine
Wei-Bo Zhang, De-Xian Jia, Hong-Yan Li, Yu-Long Wei, Huang Yan, Peng-Na Zhao, Fei-Fei Gu, Guang-Jun Wang, Yan-Ping Wang
Qi, blood and the meridians are fundamental concepts in Chinese medicine (CM), which are components of the human body and maintain physiological function. Pathological changes of qi, blood and meridians may lead to discomfort and disease. Treatment with acupuncture or herbal medicine aims to regulate qi and blood so as to recover normal function of the meridians. This paper explores the nature of qi as well as compares and correlates them with the structures of the human body. We propose a conceptualization of qi as being similar to the interstitial flfl uid, and the meridians as being similar to interstitial space of low hydraulic resistance in the body...
January 9, 2018: Chinese Journal of Integrative Medicine
Jeeyoun Jung, Mi Mi Ko, Ju Ah Lee, Myeong Soo Lee
OBJECTIVE: To investigate the diagnostic indicators and herbal treatments for blood stasis syndrome (BSS) patients with traumatic injuries and to identify the association between BSS and traumatic injury in Korea. METHODS: Two-hundred and four patients with traumatic injury were recruited from the Gangnam and Daejeon branches of Jaseng Hospital of Oriental Medicine between June 2014 and December 2014. Two independent doctors of Korean medicine (DKMs) determined the diagnosis of BSS or non-BSS based on the subjects' signs and symptoms...
January 9, 2018: Chinese Journal of Integrative Medicine
Wei-Guo Ma, Jie Wang, Xiang-Wei Bu, Hong-Hong Zhang, Jian-Ping Zhang, Xiao-Xu Zhang, Yu-Xi He, Da-Li Wang, Zheng-Ju Zhang, Feng-Xian Meng
OBJECTIVE: To observe the effects of Polygonum cuspidatum (PC) on adenosine 5'-monophosphateactivated protein kinase (AMPK), forkhead box O3α (FOXO3α), Toll-like receptor-4 (TLR4), NACHT, LRR and PYD domains-containing protein 3 (NLRP3), and monocyte chemoattractant protein-1 (MCP-1) expression in a rat model of uric acid-induced renal damage and to determine the molecular mechanism. METHODS: A rat model of uric acid-induced renal damage was established, and rats were randomly divided into a model group, a positive drug group, and high-, medium-, and low-dose Chinese medicine (CM) PC groups (n=12 per group)...
December 28, 2017: Chinese Journal of Integrative Medicine
Jin-Woo Jung, Seung Hwan Jeon, Woong Jin Bae, Su Jin Kim, Mun Su Chung, Byung Il Yoon, Sae Woong Choi, U Syn Ha, Sung Yeoun Hwang, Sae Woong Kim
OBJECTIVE: To investigate the anti-oxidative stress and preventive effect of modified Gongjin-dan (WSY-1075) in a detrusor underactivity rat model. METHODS: Rats were randomly allocated to three groups: sham-operated (control), bladder outlet obstruction-induced detrusor underactivity (BOO-DU), and BOO-DU with WSY-1075 (WSY) groups. WSY-1075 was orally administrated to rats 200 mg daily for 2 weeks prior to the operation and 4 weeks after the operation. Bladder outlet obstruction was surgically induced in rats by ligation around the urethra avoiding total obstruction...
December 21, 2017: Chinese Journal of Integrative Medicine
Hong-Bo Shen, Ze-Jun Huo, Yun-Jing Bai, Xiao-Juan He, Chang-Hong Li, Yu-Kun Zhao, Qing-Qing Guo
OBJECTIVE: To observe the effect of norcantharidin (NCTD) on collagen-induced arthritis (CIA) rats. METHODS: Sixty Sprague-Dawley(SD) rats were randomly divided into 6 groups (n=10): normal group, CIA model group(model group), NCTD low-dose group [1.35 mg/(kg•d)], NCTD middle-dose group [2.7 mg/(kg•d)], NCTD high-dose group [5.4 mg/(kg•d)] and methotrexate (MTX) group [1.8 mg/(kg/w)]. Anesthetized rats were sacrificed by luxation of cervical vertebra after 4 weeks of administration...
December 21, 2017: Chinese Journal of Integrative Medicine
Kyungjin Lee, Bumjung Kim, Heseung Hur, Khanita Suman Chinannai, Inhye Ham, Ho-Young Choi
OBJECTIVE: To investigate the hypotensive and hypolipidemic effects of Modified Sanhuang Xiexin Decoction (, HVC1), a herbal prescription for the vascular diseases in Chinese medicine and evaluate the acute and subchronic oral toxicities. METHODS: Fifty-six spontaneous hypertensive rats (SHRs) were used to investigate the hypotensive and hypolipidemic effect of HVC1. Rats in the normal group (n=8) were fed with normal diet. The rats in the other groups (n=48) were fed with high fat and cholesterol diet for inducing hyperlipidemia models...
December 21, 2017: Chinese Journal of Integrative Medicine
Xiang He, Ping Xu, Xu-Feng He, Feng-Hua Bian, Pei-Jun Ding, Li-Li Yang, Hui-Min Zhang
OBJECTIVE: To investigate the clinical efficacy of Radix Euphorbiae Ebracteolatae in treating multiple plantar warts. METHODS: Twenty-eight patients with multiple plantar warts on both left and right feet were recruited. Warts on the left feet (treatment group) of all patients were externally treated with moderate ethanol extract of Radix Euphorbiae Ebracteolatae which was made of 30 g Radix Euphorbiae Ebracteolatae putting into 100 mL of medical ethanol (75%). For the control group, moderate dose of 0...
December 21, 2017: Chinese Journal of Integrative Medicine
Ha-Rim Kim, Guem-San Lee, Mi-Seong Kim, Do-Gon Ryu, Hong-Seob So, Hyoung-Chul Moon, Young-Rae Lee, Sei-Hoon Yang, Kang-Beom Kwon
OBJECTIVE: To examinie the synergistic effects of Banxia Xiexin Decoction (, Known as Banhasasim-tang in Korean) extract (BXDE) on cisplatin-induced cytotoxicity in the A549 human lung cancer cell lines. METHODS: A549 cells were treated with varying concentrations (50-200 μg/mL) of cisplatin and BXDE alone or in combination for 96 h. We used 1-(4,5-dimethylthiazol-2-yl)-3,5-diphenylformazan assay and flow cytometry to analyze cell viability and apoptosis, respectively...
December 16, 2017: Chinese Journal of Integrative Medicine
Karim Raafat, Fadi Hdaib
OBJECTIVES: To explore the phytotherapeutic-activities of Moringa oleifera (MO) seeds on painful diabetic neuropathy in alloxan-induced diabetic mice. METHODS: The bio-guided fractionation of MO utilizing column chromatography aided with GC-MS was used to detect the most active constituent of MO. Hyperalgesia, using tail-flick and hot-plate latency experiments, and mechanical-allodynia, utilizing von-Frey filaments, were evaluated before and after 8 weeks of intraperitoneal alloxan administration (180 mg/kg)...
December 12, 2017: Chinese Journal of Integrative Medicine
Lin-Ling Li, Xiao-Wu Liu, Fang Wu, Dong-Chang Tong, Li-Ping Ye, Hong-Xing Tao, Peng Liu, Yun-Hai Qiu, Wan-Zhang Yang
OBJECTIVE: To explore brain activations associated with electroacupuncture simulation at Tongli (HT 5) and its comparison with brain activations during picture-naming task. METHODS: Twenty healthy subjects were enrolled in this study. Half of them received electroacupuncture stimulation at HT 5 (ACUP group) and the other half of them received stimulation at a nonmeridian sham acupoint (SHAM group). All subjects performed picture-naming task. Each subject finished two runs of functional magnetic resonance imaging examinations in one session and picture-naming task was performed before electroacupuncture stimulation...
December 11, 2017: Chinese Journal of Integrative Medicine
Jia-Ying Wang, Gui-Hua Tian, You-Ping Li, Tai-Xiang Wu, Zhao-Xiang Bian, Liang Du, Hong-Cai Shang
With the introduction and development of evidence-based medicine in China, it has been spread rapidly in the area of integrative medicine (IM) and has become a new unique discipline. During almost 20 years, as one of the most important parts of evidence-based IM, systematic review (SR)/meta-analysis (MA) of IM have shown a good development momentum in the aspects of quantity, depth, breadth and influence, but also face the harsh situation of the uncontrolled quantity and quality, especially for SRs in Chinese...
December 5, 2017: Chinese Journal of Integrative Medicine
Cheng-Bin Zhang, En-Chang Li
Three features of ethics review in Chinese medicine (CM) and integrative medicine (IM) were put forward in this paper. It is consistent with the principles of ethical review in Western medicine; it has to be compliant with the laws of CM and IM; emphasis should be laid on the review of clinical practice facts and experience. Three problems were pointed out. The characteristics of CM and IM are not distinctive enough, operation procedures need to be refined and effectiveness remains to be improved. Based on the mentioned above, seven measures were proposed to improve the level and quality of ethics review in CM and IM, including better brand awareness, considerable tolerance, treatment based on disease differentiation and syndrome differentiation, scientific review and toxicity and side effects of CM, perfection of the ethics review system, reasonable procedures of ethics review and more specialized ethics review workers...
December 5, 2017: Chinese Journal of Integrative Medicine
Tae-Hun Kim, Do-Hoon Kim, Seong Gyu Lee
From the medical history of traditional Eastern Asian and Tibetan medicine, the origin and development of moxibustion seems to be closely related to Mongolia. To explore the current clinical practice of moxibustion in Mongolia, we visited a teaching hospital, the Traditional Medical Science, Technology and Production Corporation of Mongolia, in February 2014. Many types of moxibustion are found to be used, and various modalities and methods are practiced based on the principles of traditional Mongolian medicine...
December 5, 2017: Chinese Journal of Integrative Medicine
Li-Rui Tang, Yan-Yan Tao, Cheng-Hai Liu, Hai-Nan Wang
OBJECTIVE: To evaluate the preventive effect of salvianolate (Sal B) on glucose metabolism disorders of dimethylnitrosamine (DMN)-induced cirrhotic rats. METHODS: Fifty-five Wistar rats were randomly divided into a control group (n=10) and a cirrhotic group (n=45) according to a random number table. Liver cirrhosis was induced by intraperitoneal administration of DMN. The cirrhotic rats were divided into model, Sal B and metformin groups (n=15), respectively. Rats in the model group were given saline, two treatment groups were given Sal B (50 mg/kg), metformin (150 mg/kg) respectively for 28 consecutive days, while rats in the control group were injected 0...
December 5, 2017: Chinese Journal of Integrative Medicine
Shu-Kun Zhang, Nai-Qiang Cui, Yu-Zhen Zhuo, Jian-Gong Hu, Jun-Hong Liu, Di-Hua Li, Li-Hua Cui
OBJECTIVE: To investigate the effect of Modified Xiaochaihu Decoction (MXD, ) on collagen degradation in rats with chronic pancreatitis (CP). METHODS: Rats were injected dibutyltin dichloride (DBTC, 7 mg/kg of body weight) into the right caudal vein to induce CP model. Thirty heallhy male Wistar rats were randomly divided into three groups by a random number table: the control, the model and the treatment groups. Rats of treatment group were administered MXD (10 g/kg of body weight) orally once daily starting from the day post-model establishment...
November 28, 2017: Chinese Journal of Integrative Medicine
Guang-Hui An, Xiao-Ting Tang, Yao-Long Chen, Yi Zhao
OBJECTIVE: To investigate the reporting characteristics of case reports of acupuncture therapy with CAse Report (CARE) guidelines, and to explore the applicability of the guidelines for these case reports. METHODS: Case reports published from January 1, 2011 to December 31, 2013, were identified by searching PubMed and the China Biomedicine Database by using MeSH terms. Screening and data extraction of case reports were conducted by two independent researchers. Assessments based on CARE guidelines and data analysis were conducted by using Excel 2003 and RevMan 5...
November 28, 2017: Chinese Journal of Integrative Medicine
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