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Transfusion Medicine and Hemotherapy

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https://www.readbyqxmd.com/read/29070981/red-cell-genotyping-by-multiplex-pcr-identifies-antigen-matched-blood-units-for-transfusion-dependent-thai-patients
#1
Kamphon Intharanut, Sasitorn Bejrachandra, Siriporn Nathalang, Nipapan Leetrakool, Oytip Nathalang
BACKGROUND: Antigen-negative red cell transfusion is required for transfusion-dependent patients. We developed multiplex PCR for red cell genotyping and calculated the possibility of finding compatible predicted phenotypes in Thai blood donor populations according to red cell alloantibodies found among Thai patients. METHODS: 600 DNA samples obtained from unrelated healthy central and northern Thai blood donors were tested with the newly developed multiplex PCR for FY*A, FY*B, JK*A, JK*B, RHCE*e, RHCE*E, DI*A and GYP*Hut, GYP*Mur, GYP*Hop, GYP*Bun, and GYP*HF allele detections...
September 2017: Transfusion Medicine and Hemotherapy
https://www.readbyqxmd.com/read/29070980/components-in-plasma-derived-factor-viii-but-not-in-recombinant-factor-viii-downregulate-anti-inflammatory-surface-marker-cd163-in-human-macrophages-through-release-of-cxcl4-platelet-factor-4
#2
Anne Bertling, Martin F Brodde, Mayken Visser, Janina Treffon, Michelle Fennen, Anke C Fender, Reinhard Kelsch, Beate E Kehrel
BACKGROUND: Hemarthrosis, or bleeding into the joints, is a hallmark of hemophilia. Heme triggers oxidative stress, inflammation, and destruction of cartilage and bone. The haptoglobin-CD163-heme oxygenase-1 (HO-1) pathway circumvents heme toxicity through enzymatic degradation of heme and transcription of antioxidant genes. Plasma-derived factor concentrates contain many proteins that might impact on cellular pathways in joints, blood, and vessels. METHODS: Activation of platelets from healthy volunteers was assessed by flow cytometry analysis of fibrinogen binding and CD62P expression...
September 2017: Transfusion Medicine and Hemotherapy
https://www.readbyqxmd.com/read/29070979/recombinant-antibodies-to-arm-cytotoxic-lymphocytes-in-cancer-immunotherapy
#3
REVIEW
Joachim Koch, Michael Tesar
Immunotherapy has the potential to support and expand the body's own armamentarium of immune effector functions, which have been circumvented during malignant transformation and establishment of cancer and is presently considered to be the most promising treatment option for cancer patients. Recombinant antibody technologies have led to a multitude of novel antibody formats, which are in clinical development and hold great promise for future therapies. Among these formats, bispecific antibodies are extremely versatile due to their high efficacy to recruit and activate anti-tumoral immune effector cells, their excellent safety profile, and the opportunity for use in combination with cellular therapies...
September 2017: Transfusion Medicine and Hemotherapy
https://www.readbyqxmd.com/read/29070978/modulating-cytotoxic-effector-functions-by-fc-engineering-to-improve-cancer-therapy
#4
REVIEW
Christian Kellner, Anna Otte, Elisa Cappuzzello, Katja Klausz, Matthias Peipp
In the last two decades, monoclonal antibodies have revolutionized the therapy of cancer patients. Although antibody therapy has continuously been improved, still a significant number of patients do not benefit from antibody therapy. Therefore, rational optimization of the antibody molecule by Fc engineering represents a major area of translational research to further improve this potent therapeutic option. Monoclonal antibodies are able to trigger a variety of effector mechanisms. Especially Fc-mediated effector functions such as antibody-dependent cell-mediated cytotoxicity (ADCC), antibody-dependent cellular phagocytosis (ADCP), and complement- dependent cytotoxicity (CDC) are considered important in antibody therapy of cancer...
September 2017: Transfusion Medicine and Hemotherapy
https://www.readbyqxmd.com/read/29070977/antibody-isotypes-for-tumor-immunotherapy
#5
REVIEW
Anna Kretschmer, Ralf Schwanbeck, Thomas Valerius, Thies Rösner
Compared to the evolutionary diversity of antibody isotypes, the spectrum of currently approved therapeutic antibodies is biased to the human IgG1 isotype. Detailed studies into the different structures and functions of human isotypes have suggested that other isotypes than IgG1 may be advantageous for specific indications - depending on the complex interplay between the targeted antigen or epitope, the desired mode of action, the pharmacokinetic properties, and the biopharmaceutical considerations. Thus, it may be speculated that with the increasing number of antibodies becoming available against a broadening spectrum of target antigens, identification of the optimal antibody isotype for particular therapeutic applications may become critical for the therapeutic success of individual antibodies...
September 2017: Transfusion Medicine and Hemotherapy
https://www.readbyqxmd.com/read/29070976/designing-human-antibodies-by-phage-display
#6
REVIEW
André Frenzel, Jonas Kügler, Saskia Helmsing, Doris Meier, Thomas Schirrmann, Michael Hust, Stefan Dübel
With six approved products and more than 60 candidates in clinical testing, human monoclonal antibody discovery by phage display is well established as a robust and reliable source for the generation of therapeutic antibodies. While a vast diversity of library generation philosophies and selection strategies have been conceived, the power of molecular design offered by controlling the in vitro selection step is still to be recognized by a broader audience outside of the antibody engineering community. Here, we summarize some opportunities and achievements, e...
September 2017: Transfusion Medicine and Hemotherapy
https://www.readbyqxmd.com/read/29070975/human-antibody-fusion-proteins-antibody-drug-conjugates-in-breast-and-ovarian-cancer
#7
REVIEW
Eden R Padayachee, Fleury Augustin Nsole Biteghe, Zaria Malindi, Dirk Bauerschlag, Stefan Barth
Considerable research efforts have been dedicated to understanding ovarian and breast cancer mechanisms, but there has been little progress translating the research into effective clinical applications. Hence, personalized/precision medicine has emerged because of its potential to improve the accuracy of tumor targeting and minimize toxicity to normal tissue. Targeted therapy in both breast and ovarian cancer has focused on antibodies, antibody drug conjugates (ADCs), and very recently the introduction of human antibody fusion proteins...
September 2017: Transfusion Medicine and Hemotherapy
https://www.readbyqxmd.com/read/29070974/an-fc-double-engineered-cd20-antibody-with-enhanced-ability-to-trigger-complement-dependent-cytotoxicity-and-antibody-dependent-cell-mediated-cytotoxicity
#8
Tim Wirt, Sophia Rosskopf, Thies Rösner, Klara Marie Eichholz, Anne Kahrs, Sebastian Lutz, Anna Kretschmer, Thomas Valerius, Katja Klausz, Anna Otte, Martin Gramatzki, Matthias Peipp, Christian Kellner
BACKGROUND: Engineering of the antibody's fragment crystallizable (Fc) by modifying the amino acid sequence (Fc protein engineering) or the glycosylation pattern (Fc glyco-engineering) allows enhancing effector functions of tumor targeting antibodies. Here, we investigated whether complement-dependent cytotoxicity (CDC) and antibody-dependent cell-mediated cytotoxicity (ADCC) of CD20 antibodies could be improved simultaneously by combining Fc protein engineering and glyco-engineering technologies...
September 2017: Transfusion Medicine and Hemotherapy
https://www.readbyqxmd.com/read/29070973/antibody-engineering-tailor-made-next-generation-antibodies-by-molecular-design
#9
EDITORIAL
Andreas Humpe, Matthias Peipp
No abstract text is available yet for this article.
September 2017: Transfusion Medicine and Hemotherapy
https://www.readbyqxmd.com/read/29070972/congress-of-the-german-society-of-transfusion-medicine-and-immunohematology-50th-anniversary
#10
EDITORIAL
Harald Klüter, Birgit Gathof, Peter Schlenke
No abstract text is available yet for this article.
September 2017: Transfusion Medicine and Hemotherapy
https://www.readbyqxmd.com/read/28924431/occult-hepatitis-infection-in-transfusion-medicine-screening-policy-and-assessment-of-current-use-of-anti-hbc-testing
#11
REVIEW
Antonella Esposito, Chiara Sabia, Carmela Iannone, Giovanni F Nicoletti, Linda Sommese, Claudio Napoli
HBV still represents a global risk factor in transfusion medicine. The residual risk of HBV is not limited to pre-seroconversion window period but it extends to donors with occult HBV infection (OBI) characterized by the presence of HBV DNA in liver and by the absence of the virus surface antigen. Each country developed an appropriate blood screening policy according to local HBV prevalence, yields of infectious units per different screening methods and cost-effectiveness. We underline the need of maintaining a high level of attention for OBI carrier identification in all blood banks worldwide where the screening procedures are generally based on a combination of both serological markers and nucleic acid amplification test...
August 2017: Transfusion Medicine and Hemotherapy
https://www.readbyqxmd.com/read/28924430/selecting-the-right-donors-still-a-challenge-development-of-a-uniform-donor-questionnaire-in-germany
#12
REVIEW
Ruth Offergeld, Margarethe Heiden
The selection of blood donors includes the assessment of the individual's health and medical history by using a donor questionnaire (DQ) in order to identify persons whose donation could present a health risk to recipients or to themselves. This way, DQs provide one layer of blood safety and contribute to the high safety profile of blood components currently available in Germany. This review reports the development of a new uniform questionnaire in Germany and its first evaluation using a field test approach...
August 2017: Transfusion Medicine and Hemotherapy
https://www.readbyqxmd.com/read/28924429/administration-safety-of-blood-products-lessons-learned-from-a-national-registry-for-transfusion-and-hemotherapy-practice
#13
Thomas Frietsch, Daffyd Thomas, Michael Schöler, Birgit Fleiter, Martin Schipplick, Michael Spannagl, Ralf Knels, Xuan Nguyen
BACKGROUND: Compared to blood component safety, the administration of blood may not be as safe as intended. The German Interdisciplinary Task Force for Clinical Hemotherapy (IAKH) specialized registry for administration errors of blood products was chosen for a detailed analysis of reports. METHODS: Voluntarily submitted critical incident reports (n = 138) from 2009 to 2013 were analyzed. RESULTS: Incidents occurred in the operation room (34...
August 2017: Transfusion Medicine and Hemotherapy
https://www.readbyqxmd.com/read/28924428/good-feasibility-of-the-new-german-blood-donor-questionnaire
#14
Claudia Houareau, Robert Deitenbeck, Ariane Sümnig, Anette Moeller, Christiane Saadé, Frank Stötzer, Margarethe Heiden, Hinnak Northoff, Ruth Offergeld
BACKGROUND: We assessed the effect of the uniform donor questionnaire (UDQ) on deferral rates in first-time and repeat donors. We focused on the introduced question about unprotected sexual contact with a new partner. Another goal was a stratified comparison of the deferral rates of the donor questionnaire (DQ) and UDQ. METHODS: Data on donors and deferrals using the DQ and UDQ were collected at four blood establishments. The comparison included a 2-year period by questionnaire version...
August 2017: Transfusion Medicine and Hemotherapy
https://www.readbyqxmd.com/read/28924427/longitudinal-changes-in-the-blood-supply-and-demand-in-north-east-germany-2005-2015
#15
Linda Schönborn, Kerstin Weitmann, Nico Greger, Volker Kiefel, Wolfgang Hoffmann, Andreas Greinacher
BACKGROUND: Securing future blood supply is a major issue of transfusion safety. In this prospective 10-year longitudinal study we enrolled all blood donation services and hospitals of the federal state Mecklenburg-Western Pomerania. METHODS AND RESULTS: From 2005 to 2015 (time period with major demographic effects), whole blood donation numbers declined by 18%. In male donors this paralleled the demographic change, while donation rates of females declined 12.4% more than expected from demography...
August 2017: Transfusion Medicine and Hemotherapy
https://www.readbyqxmd.com/read/28924426/changes-in-the-whole-blood-donor-population-in-south-west-germany-2010-versus-2016
#16
Michael Müller-Steinhardt, Christian Weidmann, Harald Klüter
BACKGROUND: In the recent past, the discrepancy between blood supply and future demand may have been overestimated. As medical progress develops rapidly, it will be essential to monitor ongoing demographic changes in the donor population regularly and to re-evaluate retention and recruiting strategies. The aim of the current study was to compare first-time donor (FTD) characteristics and their return rates. We therefore compared whole blood (WB) donations in total and the annual donation frequencies in 2010 and in 2015/2016...
August 2017: Transfusion Medicine and Hemotherapy
https://www.readbyqxmd.com/read/28924425/blood-group-distribution-in-switzerland-a-historical-comparison
#17
Thomas Volken, Rebecca J Crawford, Soraya Amar, Edgar Mosimann, Anita Tschaggelar, Behrouz Mansouri Taleghani
BACKGROUND: Ethnicities differ in prevalence of blood groups and antigens. Substantial donor-recipient mismatch within mixed-ethnic societies may render certain recipients at higher risk for alloimmunization. Data regarding antigen distribution within Switzerland by ethnicity is limited. We examined immigration patterns against the distribution of ABO blood groups using large cross-sectional Swiss samples spanning 70 years. METHODS: Historical ABO blood group distribution data (1940-1945) from Swiss army personnel (n = 275,664) were sourced from the literature...
August 2017: Transfusion Medicine and Hemotherapy
https://www.readbyqxmd.com/read/28924424/health-services-research
#18
EDITORIAL
Behrouz Mansouri Taleghani, Hans-Gert Heuft
No abstract text is available yet for this article.
August 2017: Transfusion Medicine and Hemotherapy
https://www.readbyqxmd.com/read/28626370/donor-safety-in-haemapheresis-development-of-an-internet-based-registry-for-comprehensive-assessment-of-adverse-events-from-healthy-donors
#19
Hans-Gert Heuft, Eike Fischer, Tina Weingand, Thomas Burkhardt, Gerda Leitner, Hagen Baume, Jörg-Peter Schmidt, Andreas Buser, Gabriele Fauchald, Ute Reinicke Voigt, Behrouz Mansouri-Taleghani
BACKGROUND: Currently, there is an extensive but highly inconsistent body of literature regarding donor adverse events (AEs) in haemapheresis. As the reports diverge with respect to types and grading of AEs, apheresis procedures and machines, the range of haemapheresis-related AEs varies widely from about 0.03% to 6.6%. METHODS: The German Society for Transfusion Medicine and Immunohaematology (DGTI) formed a 'Haemapheresis Vigilance Working Party' (Arbeitsgemeinschaft Hämapheresevigilanz; AGHV) to create an on-line registry for comprehensive and comparable AE assessment with all available apheresis devices in all types of preparative haemapheresis: plasmapheresis (PLS), plateletpheresis (PLT), red blood cell apheresis, all kind of leukaphereses (autologous/allogeneic blood stem cell apheresis, granulocyte apheresis, lymphocyte/monocyte apheresis) and all possible types of multi-component apheresis...
June 2017: Transfusion Medicine and Hemotherapy
https://www.readbyqxmd.com/read/28626369/biophysical-and-biochemical-markers-of-red-blood-cell-fragility
#20
Ariel Orbach, Orly Zelig, Saul Yedgar, Gregory Barshtein
BACKGROUND: Red blood cells (RBCs) undergo a natural aging process occurring in the blood circulation throughout the RBC lifespan or during routine cold storage in the blood bank. The aging of RBCs is associated with the elevation of mechanical fragility (MF) or osmotic fragility (OF) of RBCs, which can lead to cell lysis. The present study was undertaken to identify RBC properties that characterize their susceptibility to destruction under osmotic/mechanical stress. METHODS: RBCs were isolated from freshly donated blood or units of packed RBCs (PRBCs) and suspended in albumin-supplemented phosphate-buffered saline (PBS)...
June 2017: Transfusion Medicine and Hemotherapy
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