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Transfusion Medicine and Hemotherapy

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https://www.readbyqxmd.com/read/27994533/zika-virus-zikv
#1
(no author information available yet)
No abstract text is available yet for this article.
November 2016: Transfusion Medicine and Hemotherapy
https://www.readbyqxmd.com/read/27994532/severe-hypoxemia-in-a-healthy-donor-for-allogeneic-hematopoietic-stem-cell-transplantation-after-only-the-first-administration-of-granulocyte-colony-stimulating-factor
#2
Keita Yamamoto, Noriko Doki, Yasushi Senoo, Yuho Najima, Takeshi Kobayashi, Kazuhiko Kakihana, Kyoko Haraguchi, Yoshiki Okuyama, Hisashi Sakamaki, Kazuteru Ohashi
BACKGROUND: Granulocyte-colony stimulating factor (G-CSF) is widely used to mobilize peripheral blood stem cells (PBSCs) in healthy donors. A few reports have shown that some healthy donors developed acute respiratory distress syndrome or capillary leak syndrome after more than several rounds of G-CSF administration or leukapheresis. CASE REPORT: We report the case of a healthy donor for allogeneic stem cell transplantation who developed severe hypoxemia 1 h after only the first administration of G-CSF...
November 2016: Transfusion Medicine and Hemotherapy
https://www.readbyqxmd.com/read/27994531/kinship-testing-based-on-snps-using-microarray-system
#3
Sohee Cho, Hee Jin Seo, Jihyun Lee, Hyung Jin Yu, Soong Deok Lee
BACKGROUND: Kinship testing using biallelic SNP markers has been demonstrated to be a promising approach as a supplement to standard STR typing, and several systems, such as pyrosequencing and microarray, have been introduced and utilized in real forensic cases. The Affymetrix microarray containing 169 autosomal SNPs developed for forensic application was applied to our practical case for kinship analysis that had remained inconclusive due to partial STR profiles of degraded DNA and possibility of inbreeding within the population...
November 2016: Transfusion Medicine and Hemotherapy
https://www.readbyqxmd.com/read/27994530/knowledge-is-safety-the-time-is-ripe-for-hepatitis-e-virus-blood-donor-screening
#4
EDITORIAL
Tanja Vollmer, Cornelius Knabbe, Jens Dreier
No abstract text is available yet for this article.
November 2016: Transfusion Medicine and Hemotherapy
https://www.readbyqxmd.com/read/27994529/anti-d-antibodies-in-pregnant-d-variant-antigen-carriers-initially-typed-as-rhd
#5
Jelena Lukacevic Krstic, Slavica Dajak, Jasna Bingulac-Popovic, Vesna Dogic, Jela Mratinovic-Mikulandra
BACKGROUND: To evaluate the incidence, the consequences, and the prevention strategy of anti-D alloimmunizations of D variant carriers in the obstetric population of Split-Dalmatia County, Croatia. METHODS: RhD immunization events were evaluated retrospectively for the period between 1993 and 2012. Women were tested for RhD antigen and irregular antibodies. Those with anti-D antibody who were not serologically D- were genotyped for RHD. They were evaluated for their obstetric and transfusion history and their titer of anti-D...
November 2016: Transfusion Medicine and Hemotherapy
https://www.readbyqxmd.com/read/27994528/a-case-of-possible-chagas-transmission-by-blood-transfusion-in-switzerland
#6
Judith Ries, Adriana Komarek, Jochen Gottschalk, Birgit Brand, Lorenz Amsler, Markus Jutzi, Beat M Frey
BACKGROUND: Transfusion-transmitted Chagas disease has been reported from endemic countries in Latin America. Switzerland is a non-endemic country but high prevalence of antibodies against Trypanosoma cruzi was found among immigrants. Immigrants may participate in blood donation; therefore, risk-adapted anti-T. cruzi screening for blood donors was implemented in Switzerland in 2013. METHODS: Between January 2013 and July 2015, 1 out of 1,183 at-risk donors, tested at Blood Transfusion Service Zurich, was found anti-T...
November 2016: Transfusion Medicine and Hemotherapy
https://www.readbyqxmd.com/read/27994527/generalizability-of-dutch-prediction-models-for-low-hemoglobin-deferral-a-study-on-external-validation-and-updating-in-swiss-whole-blood-donors
#7
A Mireille Baart, Stefano Fontana, Anita Tschaggelar, Martijn W Heymans, Wim L A M de Kort
BACKGROUND: Sex-specific prediction models for low hemoglobin (Hb) deferral have been developed in Dutch whole blood donors. In this study, we validated and updated the models in a cohort of Swiss whole blood donors. METHODS: Prospectively collected data from 53,772 Swiss whole blood donors were used. The predictive performance of the Dutch models was assessed in terms of calibration (agreement between predicted probabilities and observed frequencies) and discrimination (ability to discriminate between deferred and approved donors)...
November 2016: Transfusion Medicine and Hemotherapy
https://www.readbyqxmd.com/read/27994526/too-many-blood-donors-response-bias-in-the-swiss-health-survey-2012
#8
Thomas Volken, Andreas Bänziger, Andreas Buser, Damiano Castelli, Stefano Fontana, Beat M Frey, Amira Sarraj, Jörg Sigle, Jutta Thierbach, Tina Weingand, Behrouz Mansouri-Taleghani
BACKGROUND: Data on blood donor status obtained from general surveys and health interview surveys have been widely used. However, the integrity of data on self-reported blood donor status from surveys may be threatened by sampling and non-sampling error. Our study aimed to compare self-reported blood donors (including one-time as well as regular donors) from the Swiss Health Survey 2012 (SHS) with register-based blood donors recorded by blood establishments and evaluate the direction and magnitude of bias in the SHS...
November 2016: Transfusion Medicine and Hemotherapy
https://www.readbyqxmd.com/read/27994525/changing-the-30-min-rule-in-canada-the-effect-of-room-temperature-on-bacterial-growth-in-red-blood-cells
#9
Sandra Ramirez-Arcos, Yuntong Kou, Éric Ducas, Louis Thibault
BACKGROUND: To maintain product quality and safety, the '30-min rule' requires the discard of red blood cells (RBCs) that are exposed to uncontrolled temperatures for more than 30 min. Recent studies suggest this rule may safely be extended to a 60-min rule. METHODS: A pool-and-split design study (N = 4) was run in parallel at Canadian Blood Services (SAGM RBCs) and Héma-Québec (AS-3 RBCs). RBCs were spiked with ∼1 colony-forming unit/ml of mesophilic and psychrophilic bacteria...
November 2016: Transfusion Medicine and Hemotherapy
https://www.readbyqxmd.com/read/27994524/blood-product-supply-in-germany-the-impact-of-apheresis-and-pooled-platelet-concentrates
#10
Karin Berger, Dorothee Schopohl, Georg Wittmann, Wolfgang Schramm, Helmut Ostermann, Christina Rieger
BACKGROUND: In Germany, about 60% of all produced platelet concentrates (PCs) are apheresis PCs (APCs). Ongoing discussions on APC reimbursement and costs might lead to a potential shift in pooled PC (PPC)/APC production. Objective of this analysis was to build a comprehensive model from the societal perspective to evaluate consequences associated with shifts in platelet supply and demand. METHODS: Literature search, desktop researches on platelet supply and demand...
November 2016: Transfusion Medicine and Hemotherapy
https://www.readbyqxmd.com/read/27790081/regenerative-dentistry-animal-model-for-regenerative-endodontology
#11
Nisarat Ruangsawasdi, Matthias Zehnder, Raphael Patcas, Chafik Ghayor, Franz E Weber
BACKGROUND: Ectopic tissue has been observed frequently in human root canal specimens when cell homing studies were performed at the dorsum of rodents. In contrast, pulp-like tissue formed when immature teeth were implanted on top of the rat calvaria. It was surmised, yet not tested, that the implantation site might affect tissue ingrowth. METHODS: Four root sections from human immature molars cleaned with 5% sodium hypochlorite (NaOCl) followed by 17% ethylenediaminetetraacetic acid (EDTA) were implanted per rat (n = 5)...
September 2016: Transfusion Medicine and Hemotherapy
https://www.readbyqxmd.com/read/27781025/thrombopoietin-receptor-agonists-are-often-ineffective-in-immune-thrombocytopenia-and-or-cause-adverse-reactions-results-from-one-hand
#12
Fabian Depré, Nasra Aboud, Frauke Ringel, Abdulgabar Salama
BACKGROUND: Eltrombopag and romiplostim are thrombopoietin receptor agonists (TPOs) that have been increasingly used for the treatment of immune thrombocytopenia (ITP). Based on our experience, the incidence of abortive treatment with these drugs and the occurrence of adverse reactions that lead to therapy break-off despite response are higher than has been previously suggested. METHODS: During the last 8 years, a total of 65 patients were treated with eltrombopag and/or romiplostim at our institute...
September 2016: Transfusion Medicine and Hemotherapy
https://www.readbyqxmd.com/read/27781024/safety-of-factor-xiii-concentrate-analysis-of-more-than-20-years-of-pharmacovigilance-data
#13
Cristina Solomon, Wolfgang Korte, Dietmar Fries, Inna Pendrak, Christine Joch, Albrecht Gröner, Ingvild Birschmann
BACKGROUND: Plasma-derived factor XIII (FXIII) concentrate is an effective treatment for FXIII deficiency. We describe adverse drug reactions (ADRs) reported during pharmacovigilance monitoring of Fibrogammin®/Corifact® and review published safety data. METHODS: Postmarketing safety reports recorded by CSL Behring from June 1993 to September 2013 were analyzed. Clinical studies published during the same period were also reviewed. RESULTS: Commercial data indicated that 1,653,450,333 IU FXIII concentrate were distributed over the review period, equivalent to 1,181,036 doses for a 70 kg patient...
September 2016: Transfusion Medicine and Hemotherapy
https://www.readbyqxmd.com/read/27781023/quality-assurance-in-biobanking-for-pre-clinical-research
#14
REVIEW
Daniel Simeon-Dubach, Steffen M Zeisberger, Simon P Hoerstrup
It is estimated that not less than USD 28 billion are spent each year in the USA alone on irreproducible pre-clinical research, which is not only a fundamental loss of investment and resources but also a strong inhibitor of efficiency for upstream processes regarding the translation towards clinical applications and therapies. The issues and cost of irreproducibility has mainly been published on pre-clinical research. In contrast to pre-clinical research, test material is often being transferred into humans in clinical research...
September 2016: Transfusion Medicine and Hemotherapy
https://www.readbyqxmd.com/read/27781022/about-atmps-sops-and-gmp-the-hurdles-to-produce-novel-skin-grafts-for-clinical-use
#15
REVIEW
Fabienne Hartmann-Fritsch, Daniela Marino, Ernst Reichmann
BACKGROUND: The treatment of severe full-thickness skin defects represents a significant and common clinical problem worldwide. A bio-engineered autologous skin substitute would significantly reduce the problems observed with today's gold standard. METHODS: Within 15 years of research, the Tissue Biology Research Unit of the University Children's Hospital Zurich has developed autologous tissue-engineered skin grafts based on collagen type I hydrogels. Those products are considered as advanced therapy medicinal products (ATMPs) and are routinely produced for clinical trials in a clean room facility following the guidelines for good manufacturing practice (GMP)...
September 2016: Transfusion Medicine and Hemotherapy
https://www.readbyqxmd.com/read/27781021/the-use-of-adipose-tissue-derived-progenitors-in-bone-tissue-engineering-a-review
#16
REVIEW
Indranil Bhattacharya, Chafik Ghayor, Franz E Weber
2500 years ago, Hippocrates realized that bone can heal without scaring. The natural healing potential of bone is, however, restricted to small defects. Extended bone defects caused by trauma or during tumor resections still pose a huge problem in orthopedics and cranio-maxillofacial surgery. Bone tissue engineering strategies using stem cells, growth factors, and scaffolds could overcome the problems with the treatment of extended bone defects. In this review, we give a short overview on bone tissue engineering with emphasis on the use of adipose tissue-derived stem cells and small molecules...
September 2016: Transfusion Medicine and Hemotherapy
https://www.readbyqxmd.com/read/27781020/stem-cells-in-functional-bladder-engineering
#17
REVIEW
Jakub Smolar, Souzan Salemi, Maya Horst, Tullio Sulser, Daniel Eberli
Conditions impairing bladder function in children and adults, such as myelomeningocele, posterior urethral valves, bladder exstrophy or spinal cord injury, often need urinary diversion or augmentation cystoplasty as when untreated they may cause severe bladder dysfunction and kidney failure. Currently, the gold standard therapy of end-stage bladder disease refractory to conservative management is enterocystoplasty, a surgical enlargement of the bladder with intestinal tissue. Despite providing functional improvement, enterocystoplasty is associated with significant long-term complications, such as recurrent urinary tract infections, metabolic abnormalities, stone formation, and malignancies...
September 2016: Transfusion Medicine and Hemotherapy
https://www.readbyqxmd.com/read/27781019/stem-cell-mediated-regeneration-of-the-adult-brain
#18
REVIEW
Sebastian Jessberger
Acute or chronic injury of the adult mammalian brain is often associated with persistent functional deficits as its potential for regeneration and capacity to rebuild lost neural structures is limited. However, the discovery that neural stem cells (NSCs) persist throughout life in discrete regions of the brain, novel approaches to induce the formation of neuronal and glial cells, and recently developed strategies to generate tissue for exogenous cell replacement strategies opened novel perspectives how to regenerate the adult brain...
September 2016: Transfusion Medicine and Hemotherapy
https://www.readbyqxmd.com/read/27781018/tissue-engineering-and-regenerative-medicine-new-initiatives-for-individual-treatment-offers
#19
EDITORIAL
Beat M Frey, Steffen M Zeisberger, Simon P Hoerstrup
No abstract text is available yet for this article.
September 2016: Transfusion Medicine and Hemotherapy
https://www.readbyqxmd.com/read/27721708/in-vivo-adsorption-of-isoagglutinins-with-incompatible-red-blood-cell-transfusion-in-stem-cell-transplant-recipients
#20
Rainer Moog
No abstract text is available yet for this article.
July 2016: Transfusion Medicine and Hemotherapy
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