journal
MENU ▼
Read by QxMD icon Read
search

Transfusion Medicine and Hemotherapy

journal
https://www.readbyqxmd.com/read/29928175/the-role-of-autologous-platelet-concentrates-in-alveolar-socket-preservation-a-systematic-review
#1
REVIEW
Marco Annunziata, Luigi Guida, Livia Nastri, Angelantonio Piccirillo, Linda Sommese, Claudio Napoli
Prevention of alveolar bone resorption after tooth extraction may be useful for implant rehabilitation of the edentulous site minimizing the future need for bone augmentation procedures. A number of studies have investigated the efficacy of autologous platelet concentrates for the preservation of the alveolar bone volume after tooth extraction. Although encouraging results have been published, the available data are still controversial. The aim of the present systematic review was to assess the effect of platelet concentrates on alveolar socket preservation after tooth extraction...
May 2018: Transfusion Medicine and Hemotherapy
https://www.readbyqxmd.com/read/29928174/characteristics-of-extracellular-vesicles-in-red-blood-concentrates-change-with-storage-time-and-blood-manufacturing-method
#2
Ruqayyah J Almizraq, Jelena L Holovati, Jason P Acker
Background: Extracellular vesicles (EVs) in blood products are potential effectors of inflammation and coagulation after transfusion. The aim of this study was to assess the impact of different blood manufacturing methods and duration of hypothermic storage on the EV subpopulations in relation to other in vitro quality parameters of red blood cell concentrate (RCC) products. Methods: RCCs were produced using whole blood filtration (WBF) or red cell filtration (RCF) (n = 12/method), refrigerated for 43 days, and evaluated for EV size profile and concentration, red cell deformability, ATP and 2,3-DPG, hemolysis, and hematological indices...
May 2018: Transfusion Medicine and Hemotherapy
https://www.readbyqxmd.com/read/29928173/red-cell-alloantibody-screening-comparative-analysis-of-three-different-technologies
#3
Nicoletta Orlando, Maria Bianchi, Caterina Giovanna Valentini, Maddalena Maresca, Giuseppina Massini, Rossana Putzulu, Gina Zini, Luciana Teofili
Background: The detection of irregular antibody is a critical issue in the management of red blood cell transfusion according to the Type & Screen (T&S) practice. In order to implement the T&S procedure at our blood bank, we compared three different automated analyzers based on column agglutination technique (CAT) or solid phase red cell adherence assay (SPACA) methods. Methods: Pre-transfusion antibody screening was performed in 986 patients candidate to elective surgery at low risk for red blood cell transfusion...
May 2018: Transfusion Medicine and Hemotherapy
https://www.readbyqxmd.com/read/29928172/rhd-positive-alleles-among-d-c-e-individuals-from-india
#4
Swati S Kulkarni, Harita Gogri, Disha Parchure, Garima Mishra, Kanjaksha Ghosh, Sunil Rajadhyaksha, Manisha Madkaikar, Claude Férec, Yann Fichou
Background: Molecular bases of blood group systems, including Rh blood group, have been poorly studied in the Indian population so far, while specificities of Europeans, East Asians and Africans have been well known for years. In order to gain insights into the molecular bases of this population, we sought to characterize the RHD allele in D- Indian donors expressing C and/or E antigen(s). Methods: RHD gene was analyzed in 171 serologically D-, C/E+ samples by standard molecular methods such as quantitative, multiplex PCR of short fluorescent fragments (QMPSF) and direct sequencing when necessary...
May 2018: Transfusion Medicine and Hemotherapy
https://www.readbyqxmd.com/read/29928171/platelet-transfusion-induces-alloimmunization-to-d-and-non-d-rhesus-antigens
#5
Johanna Reckhaus, Markus Jutzi, Stefano Fontana, Vera Ulrike Bacher, Marco Vogt, Michael Daslakis, Behrouz Mansouri Taleghani
Background: Platelet concentrates (PC) contain residual contaminating red blood cells (RBC), being higher in pooled buffy coat PC (BC-PC) than in apheresis units (AP-PC). Data about PC-induced alloimmunization against non-D Rhesus (Rh) antigens are limited. Methods: For all newly detected RhD and non-D alloantibodies between August 2015 and September /2017 we prospectively evaluated if they were triggered through PC by analyzing for incompatible RBC and/or PC transfusions...
May 2018: Transfusion Medicine and Hemotherapy
https://www.readbyqxmd.com/read/29928170/anti-d-alloimmunization-after-rhd-positive-platelet-transfusion-in-rhd-negative-women-under-55-years-diagnosed-with-acute-leukemia-results-of-a-retrospective-study
#6
REVIEW
Ana Villalba, Marta Santiago, Carmen Freiria, Pau Montesinos, Ines Gomez, Carolina Fuentes, Rebeca Rodriguez-Veiga, José María Fernandez, Guillermo Sanz, Miguel Angel Sanz, Nelly Carpio, Pilar Solves
Background: Anti-D alloimmunization can occur when platelets from RhD-positive donors are transfused to RhD-negative patients, due to red blood cell residues in the platelet concentrates. Methods: Our objective was to analyze the anti-D alloimmunization rate in a selected group of women under 55 years of age diagnosed with acute leukemia over an 18-year period. We focused the analysis on RhD-negative patients who received RhD-positive platelet transfusions. Results: From January 1998 to October 2016, 382 women under 55 years were diagnosed with acute leukemia...
May 2018: Transfusion Medicine and Hemotherapy
https://www.readbyqxmd.com/read/29928169/unmatched-type-o-rhd-red-blood-cells-in-multiple-injured-patients
#7
Sabine Flommersfeld, Carsten Mand, Christian A Kühne, Gregor Bein, Steffen Ruchholtz, Ulrich J Sachs
Background: Immediate supply of red blood cell (RBC) concentrates is crucial in the initial treatment of exsanguinating patients in the emergency room. General shortage of RhD- RBCs has led to protocols in which patients with unknown blood groups are initially transfused with group O, RhD+ RBCs. Limited data are available regarding the safety of such an approach. Methods: Transfusion protocols for all multiple injured patients from the regional polytrauma database were retrospectively analyzed over a period of 5 years...
May 2018: Transfusion Medicine and Hemotherapy
https://www.readbyqxmd.com/read/29928168/nationwide-implementation-of-pathogen-inactivation-for-all-platelet-concentrates-in-switzerland
#8
Markus Jutzi, Behrouz Mansouri Taleghani, Morven Rueesch, Lorenz Amsler, Andreas Buser
Introduction: Bacterial contamination of platelet concentrates (PCs) has been identified as the most prevalent transfusion-associated infectious risk. To prevent PC-related septic transfusion reactions, the Intercept® pathogen inactivation procedure was introduced for all PCs in Switzerland in 2011. Methods: Based on numbers of transfused units and mandatorily reported adverse events with high imputability, we compare the risks associated with transfusion of conventional PCs (cPCs) and pathogen-inactivated PCs (PI-PCs)...
May 2018: Transfusion Medicine and Hemotherapy
https://www.readbyqxmd.com/read/29928167/hemovigilance
#9
EDITORIAL
Hans-Gert Heuft, Behrouz Mansouri Taleghani
No abstract text is available yet for this article.
May 2018: Transfusion Medicine and Hemotherapy
https://www.readbyqxmd.com/read/29765296/peripartum-haemorrhage-haemostatic-aspects-of-the-new-german-pph-guideline
#10
REVIEW
Heiko Lier, Christian von Heymann, Wolfgang Korte, Dietmar Schlembach
Summary Peripartum haemorrhage remains one of the main causes of maternal mortality world-wide. The German, Austrian and Swiss Societies of Gynaecology and Obstetrics have updated the current guidelines for the treatment of peripartum haemorrhage together with the German Society of Anaesthesiology and Intensive Care Medicine and the Society of Thrombosis and Haemostasis Research. The recommendations have been the result of a thorough review of the available scientific literature and a consensus process involving all members of the guideline group...
April 2018: Transfusion Medicine and Hemotherapy
https://www.readbyqxmd.com/read/29765295/incentives-for-blood-donation-a-discrete-choice-experiment-to-analyze-extrinsic-motivation
#11
Andrew Sadler, Ling Shi, Susanne Bethge, Axel Mühlbacher
Background: Demographic trends affect size and age structure of populations. One of the consequences will be an increasing need for blood products to treat age-related diseases. Donation services rely on voluntariness and charitable motivation. It might be questioned whether there will be sufficient blood supply with voluntary donation. The present study focused on elicitation of preferences for incentives and aimed to contribute to the discussion on how to increase donation rates. Methods: A self-administered discrete choice experiment (DCE) was applied...
April 2018: Transfusion Medicine and Hemotherapy
https://www.readbyqxmd.com/read/29765294/which-infectious-blood-donors-could-be-identified-by-the-donor-history-questionnaire-comparison-of-blood-donors-infected-with-hiv-or-hcv-with-notified-cases-from-general-population-in-germany
#12
Karina Preußel, Ruth Offergeld
Background: Potential risks for transfusion-transmissible infections are identified by donor history questionnaires (DHQs), and donors with higher risks are deferred from donation. We assessed to which extent the currently used DHQs support the identification of infections among blood donors. Methods: Between 2006 and 2013, we analyzed data from notified HIV and HCV cases in the general population and positive blood donors in Germany. Logistic regressions were used to identify relevant infection risks...
April 2018: Transfusion Medicine and Hemotherapy
https://www.readbyqxmd.com/read/29765293/recurrent-bleedings-in-newborn-a-factor-vii-deficiency-case-report
#13
Kim Cattivelli, Cristina Distefano, Lorenza Bonetti, Sophie Testa, Simona Maria Siboni, Alessandro Plebani, Carlo Poggiani
Background: Major hemorrhages in newborns can be caused by several conditions, and knowledge of the differential diagnosis is essential in order to ensure prompt recognition and appropriate treatment. Case Report: We describe the case of a male newborn experiencing recurrent hemorrhages from the first days of life. Laboratory findings showed normal platelet count, hepatic function, and C-reactive protein. Coagulation tests detected an isolated prothrombin time (PT) prolongation and severe factor VII (FVII) deficiency...
April 2018: Transfusion Medicine and Hemotherapy
https://www.readbyqxmd.com/read/29765292/platelet-additive-solutions-a-review-of-the-latest-developments-and-their-clinical-implications
#14
REVIEW
Pieter F van der Meer, Dirk de Korte
Summary Platelet additive solutions (PASs) have undergone many reformulations in order to further improve platelet storage. Studies of platelets stored in PAS-F (containing acetate, magnesium and potassium as key constituents) showed that platelets may be stored for 13 days with recovery and survival outcomes that are equal or even superior to 7-day stored platelets in plasma. Clinically, patients transfused with platelets in PAS have fewer allergic reactions, while for febrile reactions data are conflicting...
April 2018: Transfusion Medicine and Hemotherapy
https://www.readbyqxmd.com/read/29765291/the-potential-close-future-of-hemophilia-treatment-gene-therapy-tfpi-inhibition-antithrombin-silencing-and-mimicking-factor-viii-with-an-engineered-antibody
#15
REVIEW
Wolfgang Korte, Lukas Graf
Summary Hemophilia is one of the best researched monogenic diseases. Hemophilia A will affect approximately 1:5,000 male live births. In recent decades, great progress has been made with the introduction of recombinant proteins in the 1990s for therapy and prophylaxis, securing adequate availability and, with the introduction of the prophylaxis concept, reducing the negative impact of hemophilia on morbidity (especially arthropathy). Despite this progress, there are still challenges to overcome to secure adequate prophylaxis and treatment: for the time being, causal pharmacological hemophilia prophylaxis and therapy requires repeated i...
April 2018: Transfusion Medicine and Hemotherapy
https://www.readbyqxmd.com/read/29765290/extended-half-life-factor-viii-and-factor-ix-preparations
#16
REVIEW
Lukas Graf
In the last couple of years, several extended half-life factor VIII and factor IX preparations were intensively studied and gained approval. In order to extend half-lives, techniques like fusion to protein conjugates (Fc part of IgG1 or albumin), chemical modification (PEGylation), and protein sequence modification are implemented. With these techniques, it is possible to extend half-lives of factor IX products 4- to 6- fold, while half-life extension of factor VIII products is limited to 1.5- to 2-fold due to their interaction with von Willebrand factor...
April 2018: Transfusion Medicine and Hemotherapy
https://www.readbyqxmd.com/read/29765289/hemotherapy-with-new-blood-products
#17
EDITORIAL
Wolfgang Korte, Sacha S Zeerleder
No abstract text is available yet for this article.
April 2018: Transfusion Medicine and Hemotherapy
https://www.readbyqxmd.com/read/29593463/young-blood-rejuvenates-old-bodies-a-call-for-reflection-when-moving-from-mice-to-men
#18
Bjørn Hofmann
Connecting the circulatory system of old and young mice (parabiosis) is documented to have rejuvenating effects on cells, tissues, organs, and functions. A wide range of benefits are envisioned. Blood-based rejuvenation can come to totally change population health and aging. The first blood rejuvenation studies on humans with Alzheimer's disease have started. It puts blood at the center of therapy and revitalizes the historical line of humoral pathology from Hippocrates and Harvey, creating a new type of 'bloodletting...
January 2018: Transfusion Medicine and Hemotherapy
https://www.readbyqxmd.com/read/29593462/abo-rhesus-and-kell-antigens-alleles-and-haplotypes-in-west-bengal-india
#19
Debapriya Basu, Suvro Sankha Datta, Celina Montemayor, Prasun Bhattacharya, Krishnendu Mukherjee, Willy A Flegel
Background: Few studies have documented the blood group antigens in the population of eastern India. Frequencies of some common alleles and haplotypes were unknown. We describe phenotype, allele, and haplotype frequencies in the state of West Bengal, India. Methods: We tested 1,528 blood donors at the Medical College Hospital, Kolkata. The common antigens of the ABO, Rhesus, and Kell blood group systems were determined by standard serologic methods in tubes. Allele and haplotype frequencies were calculated with an iterative method that yielded maximum-likelihood estimates under the assumption of a Hardy-Weinberg equilibrium...
January 2018: Transfusion Medicine and Hemotherapy
https://www.readbyqxmd.com/read/29593461/interaction-of-platelet-derived-microparticles-with-a-human-b-lymphoblast-cell-line-a-clue-for-the-immunologic-function-of-the-microparticles
#20
Fatemah Yari, Mahboubeh Motefaker, Mahin Nikougoftar, Zahra Khayati
Background: Platelets are blood cells with extensive capabilities in hemostasis. They also play a central role in the development of innate and adaptive immune responses. Little information exists about the immunostimulatory role of platelet-derived microparticles (Plt-MPs). To further elucidate this issue, we conducted this study using the B-lymphoblast cell line 'Daudi' as an available surrogate cell line for peripheral blood B lymphocytes. This cell line does not produce immunoglobulins (Igs) and has low expression of activation markers...
January 2018: Transfusion Medicine and Hemotherapy
journal
journal
40445
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"