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Transfusion Medicine and Hemotherapy

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https://www.readbyqxmd.com/read/29765296/peripartum-haemorrhage-haemostatic-aspects-of-the-new-german-pph-guideline
#1
REVIEW
Heiko Lier, Christian von Heymann, Wolfgang Korte, Dietmar Schlembach
Summary Peripartum haemorrhage remains one of the main causes of maternal mortality world-wide. The German, Austrian and Swiss Societies of Gynaecology and Obstetrics have updated the current guidelines for the treatment of peripartum haemorrhage together with the German Society of Anaesthesiology and Intensive Care Medicine and the Society of Thrombosis and Haemostasis Research. The recommendations have been the result of a thorough review of the available scientific literature and a consensus process involving all members of the guideline group...
April 2018: Transfusion Medicine and Hemotherapy
https://www.readbyqxmd.com/read/29765295/incentives-for-blood-donation-a-discrete-choice-experiment-to-analyze-extrinsic-motivation
#2
Andrew Sadler, Ling Shi, Susanne Bethge, Axel Mühlbacher
Background: Demographic trends affect size and age structure of populations. One of the consequences will be an increasing need for blood products to treat age-related diseases. Donation services rely on voluntariness and charitable motivation. It might be questioned whether there will be sufficient blood supply with voluntary donation. The present study focused on elicitation of preferences for incentives and aimed to contribute to the discussion on how to increase donation rates. Methods: A self-administered discrete choice experiment (DCE) was applied...
April 2018: Transfusion Medicine and Hemotherapy
https://www.readbyqxmd.com/read/29765294/which-infectious-blood-donors-could-be-identified-by-the-donor-history-questionnaire-comparison-of-blood-donors-infected-with-hiv-or-hcv-with-notified-cases-from-general-population-in-germany
#3
Karina Preußel, Ruth Offergeld
Background: Potential risks for transfusion-transmissible infections are identified by donor history questionnaires (DHQs), and donors with higher risks are deferred from donation. We assessed to which extent the currently used DHQs support the identification of infections among blood donors. Methods: Between 2006 and 2013, we analyzed data from notified HIV and HCV cases in the general population and positive blood donors in Germany. Logistic regressions were used to identify relevant infection risks...
April 2018: Transfusion Medicine and Hemotherapy
https://www.readbyqxmd.com/read/29765293/recurrent-bleedings-in-newborn-a-factor-vii-deficiency-case-report
#4
Kim Cattivelli, Cristina Distefano, Lorenza Bonetti, Sophie Testa, Simona Maria Siboni, Alessandro Plebani, Carlo Poggiani
Background: Major hemorrhages in newborns can be caused by several conditions, and knowledge of the differential diagnosis is essential in order to ensure prompt recognition and appropriate treatment. Case Report: We describe the case of a male newborn experiencing recurrent hemorrhages from the first days of life. Laboratory findings showed normal platelet count, hepatic function, and C-reactive protein. Coagulation tests detected an isolated prothrombin time (PT) prolongation and severe factor VII (FVII) deficiency...
April 2018: Transfusion Medicine and Hemotherapy
https://www.readbyqxmd.com/read/29765292/platelet-additive-solutions-a-review-of-the-latest-developments-and-their-clinical-implications
#5
REVIEW
Pieter F van der Meer, Dirk de Korte
Summary Platelet additive solutions (PASs) have undergone many reformulations in order to further improve platelet storage. Studies of platelets stored in PAS-F (containing acetate, magnesium and potassium as key constituents) showed that platelets may be stored for 13 days with recovery and survival outcomes that are equal or even superior to 7-day stored platelets in plasma. Clinically, patients transfused with platelets in PAS have fewer allergic reactions, while for febrile reactions data are conflicting...
April 2018: Transfusion Medicine and Hemotherapy
https://www.readbyqxmd.com/read/29765291/the-potential-close-future-of-hemophilia-treatment-gene-therapy-tfpi-inhibition-antithrombin-silencing-and-mimicking-factor-viii-with-an-engineered-antibody
#6
REVIEW
Wolfgang Korte, Lukas Graf
Summary Hemophilia is one of the best researched monogenic diseases. Hemophilia A will affect approximately 1:5,000 male live births. In recent decades, great progress has been made with the introduction of recombinant proteins in the 1990s for therapy and prophylaxis, securing adequate availability and, with the introduction of the prophylaxis concept, reducing the negative impact of hemophilia on morbidity (especially arthropathy). Despite this progress, there are still challenges to overcome to secure adequate prophylaxis and treatment: for the time being, causal pharmacological hemophilia prophylaxis and therapy requires repeated i...
April 2018: Transfusion Medicine and Hemotherapy
https://www.readbyqxmd.com/read/29765290/extended-half-life-factor-viii-and-factor-ix-preparations
#7
REVIEW
Lukas Graf
In the last couple of years, several extended half-life factor VIII and factor IX preparations were intensively studied and gained approval. In order to extend half-lives, techniques like fusion to protein conjugates (Fc part of IgG1 or albumin), chemical modification (PEGylation), and protein sequence modification are implemented. With these techniques, it is possible to extend half-lives of factor IX products 4- to 6- fold, while half-life extension of factor VIII products is limited to 1.5- to 2-fold due to their interaction with von Willebrand factor...
April 2018: Transfusion Medicine and Hemotherapy
https://www.readbyqxmd.com/read/29765289/hemotherapy-with-new-blood-products
#8
EDITORIAL
Wolfgang Korte, Sacha S Zeerleder
No abstract text is available yet for this article.
April 2018: Transfusion Medicine and Hemotherapy
https://www.readbyqxmd.com/read/29593463/young-blood-rejuvenates-old-bodies-a-call-for-reflection-when-moving-from-mice-to-men
#9
Bjørn Hofmann
Connecting the circulatory system of old and young mice (parabiosis) is documented to have rejuvenating effects on cells, tissues, organs, and functions. A wide range of benefits are envisioned. Blood-based rejuvenation can come to totally change population health and aging. The first blood rejuvenation studies on humans with Alzheimer's disease have started. It puts blood at the center of therapy and revitalizes the historical line of humoral pathology from Hippocrates and Harvey, creating a new type of 'bloodletting...
January 2018: Transfusion Medicine and Hemotherapy
https://www.readbyqxmd.com/read/29593462/abo-rhesus-and-kell-antigens-alleles-and-haplotypes-in-west-bengal-india
#10
Debapriya Basu, Suvro Sankha Datta, Celina Montemayor, Prasun Bhattacharya, Krishnendu Mukherjee, Willy A Flegel
Background: Few studies have documented the blood group antigens in the population of eastern India. Frequencies of some common alleles and haplotypes were unknown. We describe phenotype, allele, and haplotype frequencies in the state of West Bengal, India. Methods: We tested 1,528 blood donors at the Medical College Hospital, Kolkata. The common antigens of the ABO, Rhesus, and Kell blood group systems were determined by standard serologic methods in tubes. Allele and haplotype frequencies were calculated with an iterative method that yielded maximum-likelihood estimates under the assumption of a Hardy-Weinberg equilibrium...
January 2018: Transfusion Medicine and Hemotherapy
https://www.readbyqxmd.com/read/29593461/interaction-of-platelet-derived-microparticles-with-a-human-b-lymphoblast-cell-line-a-clue-for-the-immunologic-function-of-the-microparticles
#11
Fatemah Yari, Mahboubeh Motefaker, Mahin Nikougoftar, Zahra Khayati
Background: Platelets are blood cells with extensive capabilities in hemostasis. They also play a central role in the development of innate and adaptive immune responses. Little information exists about the immunostimulatory role of platelet-derived microparticles (Plt-MPs). To further elucidate this issue, we conducted this study using the B-lymphoblast cell line 'Daudi' as an available surrogate cell line for peripheral blood B lymphocytes. This cell line does not produce immunoglobulins (Igs) and has low expression of activation markers...
January 2018: Transfusion Medicine and Hemotherapy
https://www.readbyqxmd.com/read/29593460/association-of-il-6-c-572g-gene-polymorphism-with-anti-e-production
#12
Jeong-Shi Lin, Li-Hsuan Lee, Hsueng-Mei Liu, Ying-Ju Chen, Tzeon-Jye Chiou
Background: Interleukin 6 (IL-6) is involved in regulation of immunoglobulin production. The aim of this study was to investigate the association between IL-6 single nucleotide polymorphisms (SNPs) in the IL-6 promoter and anti-E in red blood cell (RBC) transfusion recipients. Methods: 50 healthy subjects, 54 patients with RBC alloantibody anti-E (responders), and 45 patients without alloantibody (non-responders) were recruited. All patients were E antigen-negative...
January 2018: Transfusion Medicine and Hemotherapy
https://www.readbyqxmd.com/read/29593459/post-operative-iron-carboxymaltose-may-have-an-effect-on-haemoglobin-levels-in-cardiothoracic-surgical-patients-on-the-icu-an-observational-pilot-study-about-anaemia-treatment-with-intravenous-iron
#13
Frank Peters, Maria Eveslage, Inka Gallitz, Carola Wempe, Patrick Meybohm, Hugo K Van Aken, Andrea U Steinbicker
Background: Post-operative anaemia is associated with increased morbidity and mortality. Positive effects of post-operative intravenous iron (IVI) after elective orthopaedic, abdominal and genitourinary surgery have been reported. The current observational trial investigated the prevalence of post-operative anaemia, the effect of IVI on haemoglobin levels, the use of blood transfusions and diagnoses related to infections. Methods: 1,265 patients on five ICUs of Münster University Hospital were screened for post-operative anaemia...
January 2018: Transfusion Medicine and Hemotherapy
https://www.readbyqxmd.com/read/29593458/reactive-oxygen-species-generated-by-cd45-cells-distinct-from-leukocyte-population-in-platelet-concentrates-is-correlated-with-the-expression-and-release-of-platelet-activation-markers-during-storage
#14
Mehran Ghasemzadeh, Ehteramolsadat Hosseini, Amin Shahbaz Ghasabeh, Kamran Mousavi Hosseini
Background: Platelet stimulation with agonists is accompanied by the generation of reactive oxygen species (ROS) which promotes further platelet activation and aggregation. Considering different cell populations in platelet concentrates (PCs), this study investigates the correlation of ROS generation with the expression and release of platelet activation markers during storage. Methods: Samples obtained from 6 PCs were subjected to flow cytometry and ELISA to evaluate the expression and shedding of platelet P-selectin or CD40L during storage...
January 2018: Transfusion Medicine and Hemotherapy
https://www.readbyqxmd.com/read/29593457/platelet-count-before-peripheral-blood-stem-cell-mobilization-is-associated-with-the-need-for-plerixafor-but-not-with-the-collection-result
#15
Marc-Andrea Baertsch, Katharina Kriegsmann, Petra Pavel, Thomas Bruckner, Michael Hundemer, Mark Kriegsmann, Anthony D Ho, Hartmut Goldschmidt, Patrick Wuchter
Background: A low platelet count before mobilization has recurrently been identified as risk factor for poor mobilization. Methods: To determine the relevance of this finding for peripheral blood stem cell (PBSC) mobilization, including pre-emptive or rescue plerixafor in the case of poor mobilization, we retrospectively analyzed all patients undergoing PBSC collection at our institution between January 2014 and December 2015 (n = 380). Results: In total, 99% of the patients (377/380) successfully collected a minimum of 2 × 106 CD34+ cells/kg body weight sufficient for a single transplant...
January 2018: Transfusion Medicine and Hemotherapy
https://www.readbyqxmd.com/read/29593456/robust-production-of-cytomegalovirus-pp65-specific-t-cells-using-a-fully-automated-ifn-%C3%AE-cytokine-capture-system
#16
Nayoun Kim, Young-Sun Nam, Keon-Il Im, Jung-Yeon Lim, Young-Woo Jeon, Yunejin Song, Jong Wook Lee, Seok-Goo Cho
Background: Cytomegalovirus(CMV)-related diseases are a serious cause of morbidity and mortality following hematopoietic stem cell transplantation (HSCT). CMV-specific cytotoxic T lymphocytes (CMV-CTLs) have been reported as an alternative to antiviral drugs that provide long-term CMV-specific immunity without major side effects. However, their application has been limited by the prolonged manufacturing process required. Methods: In this study, we applied the IFN-γ cytokine capture system (CCS) using the fully automated CliniMACS Prodigy device for rapid production of CMV-CTLs, which may be applicable in clinically urgent CMV-related diseases...
January 2018: Transfusion Medicine and Hemotherapy
https://www.readbyqxmd.com/read/29593455/abo-mistyping-of-cis-ab-blood-group-by-the-automated-microplate-technique
#17
Sejong Chun, Mi Ra Ryu, Seung-Yeon Cha, Ji-Young Seo, Duck Cho
Background: The cis -AB phenotype, although rare, is the relatively most frequent of ABO subgroups in Koreans. To prevent ABO mistyping of cis -AB samples, our hospital has applied a combination of the manual tile method with automated devices. Herein, we report cases of ABO mistyping detected by the combination testing system. Methods: Cases that showed discrepant results by automated devices and the manual tile method were evaluated. These samples were also tested by the standard tube method...
January 2018: Transfusion Medicine and Hemotherapy
https://www.readbyqxmd.com/read/29344020/a-case-of-immune-thrombocytopenia-as-a-rare-side-effect-of-an-immunotherapy-with-pd1-blocking-agents-for-metastatic-melanoma
#18
Claudia Pföhler, Hermann Eichler, Barbara Burgard, Nathalie Krecké, Cornelia S L Müller, Thomas Vogt
Background: Checkpoint blocking agents such as pembrolizumab or nivolumab may induce a diversity of mostly autoimmune-mediated side effects. These autoimmune phenomena mainly affect ductless glands such as the pituitary gland (hypophysitis), the thyroid gland (thyreoiditis), the skin (vitiligo and rash), the colon (colitis), and the lung (pneumonitis). Furthermore, many other organs or organ systems may be affected. Case Report: This work describes a case of an immune thrombocytopenia that developed or rather became clinically significant shortly after initiation of a systemic therapy with first nivolumab and later pembrolizumab given due to metastatic melanoma...
November 2017: Transfusion Medicine and Hemotherapy
https://www.readbyqxmd.com/read/29344019/using-blood-donor-derived-abo-and-rhd-blood-groups-helps-to-detect-wrong-blood-in-tube-errors-in-recipients
#19
Christoffer Dellgren, Mark H Yazer, Ulrik Sprogøe
Background: Comparing the ABO and RhD group of a recipient's current pre-transfusion sample against their historical group is an important means of detecting wrong blood in tube (WBIT) errors. This study investigated the utility of using the donor ABO and RhD group as the historical check for recipients. Methods: A single database stores serological information on blood donors, pregnant women, and patients throughout southern Denmark. A donor ABO and RhD group can be the historical blood group should that donor later require a transfusion...
November 2017: Transfusion Medicine and Hemotherapy
https://www.readbyqxmd.com/read/29344018/three-year-experience-in-nat-screening-of-blood-donors-for-transfusion-transmitted-viruses-in-croatia
#20
Hana Safic Stanic, Ivana Babic, Margareta Maslovic, Vesna Dogic, Jasna Bingulac-Popovic, Manuela Miletic, Nina Jurakovic-Loncar, Tomislav Vuk, Maja Strauss-Patko, Irena Jukic
Background: Croatia implemented individual donation (ID)-NAT testing of blood donors in 2013 for three viruses HBV, HCV, and HIV-1 as a mandatory test for all blood donors. This study assessed the impact of NAT screening 3 years after its implementation. Methods: A total of 545,463 donations were collected and screened for HBV, HCV, and HIV-1 using the Procleix Ultrio Plus Assay. All initially reactive (IR) NAT samples were retested in triplicate and, if repeatedly reactive (RR), NAT discriminatory assay (dNAT) was performed...
November 2017: Transfusion Medicine and Hemotherapy
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