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Clinical Medicine & Research

Ralph Yachoui, Chady Leon, Kajal Sitwala, Mazen Kreidy
To describe clinical features and outcomes of seven patients with pulmonary mucosa-associated lymphoid tissue (MALT) lymphoma in the setting of underlying primary Sjogren's syndrome from a single center, we reviewed medical records of consecutive patients with pulmonary MALT lymphoma evaluated at our facility from January 1, 1999 to December 31, 2015 for clinical features, laboratory, pathologic and radiographic findings, management, and outcomes. Out of 13 patients with pulmonary MALT lymphoma, 7 (54 %) met the criteria for Sjogren's syndrome...
May 9, 2017: Clinical Medicine & Research
Karim Ladak, Laurence Rubin
No abstract text is available yet for this article.
May 9, 2017: Clinical Medicine & Research
Rajan Kanth, Ram Babu Shrestha, Indira Rai, Jeffrey J VanWormer, Praveen K Roy
BACKGROUND: Primary biliary cholangitis (PBC) is a rare disease with incidence that varies with time and geography. Only two studies have assessed PBC incidence of in the United States, with the most recent appearing over a decade ago. The objective of the present study was to assess PBC incidence in the United States in a more recent era. METHODS: The incidence of PBC was assessed in a population-based cohort in rural, Midwestern Wisconsin over two decades spanning from June 1992 through June 2011...
May 9, 2017: Clinical Medicine & Research
Ingrid Glurich, Gregory Nycz, Amit Acharya
Escalating prevalence of both diabetes and periodontal disease, two diseases associated with bidirectional exacerbation, has been reported. Periodontal disease represents a modifiable risk factor that may reduce diabetes onset or progression, and integrated models of cross-disciplinary care are needed to establish and manage glycemic control in affected patients. An ad-hoc environmental scan of current literature and media sought to characterize factors impacting status of integrated care models based on review of the existing evidence base in literature and media surrounding: 1) current cross-disciplinary practice patterns, 2) epidemiological updates, 3) status on risk assessment and screening for dysglycemia in the dental setting, 4) status on implementation of quality metrics for oral health, 5) care model pilots, and 6) public health perspectives...
April 3, 2017: Clinical Medicine & Research
Mahir Gachabayov, Kubach Kubachev
Today, the ingenious and untimely deceased surgeon Monastyrski's name is almost lost in the history of medicine and says little if any to young surgeons. Monastyrski Nestor Dmitrievich was born in 1847 in Czerniowce, graduated from the medical faculty of the University of Vienna. Deeply inspired by the stars of European medicine and surgery Billroth, Kaposi, Mikulicz, he became a brilliant surgeon and teacher. Monastyrski performed the first gastroenterostomy in Russia, was one of the pioneers of aseptic method in Russia...
April 3, 2017: Clinical Medicine & Research
Po-Huang Chyou, Dixie Schroeder, Kelsey Schwei, Amit Acharya
OBJECTIVE: To effectively achieve a robust survey response rate in a timely manner, an alternative approach to survey distribution, informed by statistical modeling, was applied to efficiently and cost-effectively achieve the targeted rate of return. DESIGN: A prospective environmental scan surveying adoption of health information technology utilization within their practices was undertaken in a national pool of dental professionals (N=8000) using an alternative method of sampling...
April 3, 2017: Clinical Medicine & Research
Ralph Yachoui, Nouman Farooq, Jonathan V Amos, Gene R Shaw
Angioimmunoblastic T-cell lymphoma (AITL) is a rare subtype of peripheral T-cell lymphoma (PTCL). AITL typically presents with lymphadenopathy, fever, rash, hepatosplenomegaly, and rarely polyarthritis. We report the case of a 50-year-old female who presented with lymphadenopathy, rash, and symmetric polyarthritis. She was later diagnosed with AITL and was treated with chemotherapy with resolution of arthritis. AITL should be suspected in paitents presenting with rheumatoid-like arthritis and diffuse lymphadenopathy...
December 2016: Clinical Medicine & Research
Yaqoot Fatima, Suhail A R Doi, Jake M Najman, Abdullah Al Mamun
OBJECTIVES: To explore if gender difference in sleep quality is due to higher prevalence of depression in females, and whether socio-demographic and lifestyle factors have a differential effect on sleep quality in males and females. METHODS: Youth self-reports and the Pittsburgh Sleep Quality Index were used to assess sleep quality and associated risk factors. Logistic regression analyses were used to analyze the association between various risk factors and poor sleep quality...
December 2016: Clinical Medicine & Research
Pradeep Kumar Maurya, Mayur Deepak Thakkar, Dinkar Kulshreshtha, Ajai Kumar Singh, Anup Kumar Thacker
Subacute sclerosing panencephalitis is a fatal infectious disease of childhood caused by persistence of the measles virus in the brain. The effect of human immunodeficiency virus (HIV) co-infection on subacute sclerosing panencephalitis remains elusive and rare. We report a child who developed subacute sclerosing panencephalitis following a short latency period and a rapidly progressive course with HIV co-infection.
December 2016: Clinical Medicine & Research
Conor P Kerley, Emma Kilbride, Peter Greally, Basil Elnazir
Airway nitric oxide (NO) is a ubiquitous signaling molecule with bronchoprotective, anti-inflammatory and anti-infective roles. Cystic fibrosis (CF) is a chronic lung condition associated with deceased exhaled NO. Strategies to increase exhaled NO in CF have yielded inconsistent results. A potential new method of increasing systemic NO involves ingestion of dietary, inorganic nitrate which is reduced to nitrite and NO. We present the case of a 12-year-old, athletic boy with CF who demonstrated acute but marked increases in exhaled NO following dietary nitrate consumption compared to placebo...
December 2016: Clinical Medicine & Research
Rahul Sehgal, Rafael Medina-Flores, Ralph Yachoui, Charles V Kenney
Immune mediated necrotizing myopathy (IMNM) is a unique form of myositis that is characterized by distinct muscle biopsy features including abundant myofiber necrosis, degeneration, and regeneration with only minimal, if any, inflammation on muscle biopsy. IMNM is clinically similar to idiopathic inflammatory myopathy (IIM); hence, muscle biopsy is essential to diagnose IMNM. Herein we describe a case of neck extensor weakness due to necrotizing myopathy. Isolated weakness of the neck extensor muscles is uncommon in IIM and IMNM...
December 2016: Clinical Medicine & Research
William A Agger, Charles W Schauberger, James K Burmester, Sanjay K Shukla
No abstract text is available yet for this article.
December 2016: Clinical Medicine & Research
Kristen C Iniguez, Rachel V Stankowski
BACKGROUND: Adverse childhood experiences (ACEs), including emotional abuse, substance abuse in the household, separation or divorce, physical abuse, violence between adults, mental illness in the household, sexual abuse, or incarceration of a household member, have the potential to profoundly impact health and well-being in adulthood. To assess whether previously reported relationships between ACEs and health outcomes withstand validation, we conducted a community-based ACE study with the unique capacity to link self-reported ACEs and other survey results to validated health data in an electronic medical record (EMR)...
December 2016: Clinical Medicine & Research
William Krause, Jennifer Roberts, Romel J Garcia-Montilla
No abstract text is available yet for this article.
June 2016: Clinical Medicine & Research
Matthew D'Costa, Radmila Savcic-Kos, Jingbo Huang, Andrew D Rule, Narayana Murali
BACKGROUND AND OBJECTIVES: Epidemiological evidence suggests that patients with urolithiasis are at increased risk for end-stage renal disease (ESRD). It is unclear if urological intervention impacts the progression of chronic kidney disease (CKD). METHODS: We conducted a retrospective observational cohort study of patients in the Marshfield Epidemiologic Study Area database between January 1991 and May 2007, where 1,340 patients diagnosed with urolithiasis were extracted...
June 2016: Clinical Medicine & Research
William F Wright
Bacillus cereus typically presents as a gastrointestinal infection, but rarely manifests as systemic disease. This report describes a case of B. cereus-related endocarditis that presented as a sickle cell crisis and bacteremia. Initial clinical suspicion was for laboratory contamination of blood cultures. The case herein described is intended to demonstrate an uncommon presentation of B. cereus infection and highlights the value of an aggressive need to further investigate and interpret unexpected blood culture findings in clinical practice, early adequate antimicrobial therapy, prompt diagnosis, and consideration to urgent surgical interventions in such cases...
June 2016: Clinical Medicine & Research
Michael T Sheehan
Disorders of thyroid function are common, and screening, diagnosis, and management are often performed by primary care providers. While management of significant biochemical abnormalities is reasonably straight forward, laboratory tests only slightly outside, or even within, the normal range are becoming more difficult to appropriately manage. A large part of this increasing difficulty in appropriate management is caused by patients requesting, and even demanding, certain tests or treatments that may not be indicated...
June 2016: Clinical Medicine & Research
Josiane S Almeida, Franciele M Vanderlei, Eliane C Pastre, Rodrigo A D M Martins, Carlos R Padovani, Guaracy C Filho
BACKGROUND: The aim of the present study was to assess plantar pressure distribution and musculoskeletal symptoms following the use of customized insoles among female assembly line workers. METHODS: The study included 29 female assembly line workers (age, 29.76 ± 5.79 years; weight, 63.79 ± 12.11 kg) with musculoskeletal symptoms who work predominantly while standing. The Nordic Musculoskeletal Questionnaire was administered to the study population. Plantar pressure was determined using a computerized plantar pressure feedback system...
June 2016: Clinical Medicine & Research
Christian Renner, William E Connor, Robert D Steiner
A young girl, age 8.5 years, presented with profound hypercholesterolemia and early xanthomatosis, suggesting homozygous familial (or type II) hypercholesterolemia. The patient's low density lipoprotein (LDL) receptor function and parental lipoprotein profiles were determined to be normal, prompting revision of the initial diagnosis to pseudohomozygous familial hypercholesterolemia. When she subsequently presented with giant platelets, the case was presented to colleagues on an electronic mailing list. It was recommended that plasma and sterol analysis be performed, which led to a diagnosis of sitosterolemia...
June 2016: Clinical Medicine & Research
Rita Fabiane Teixeira Gomes, Maria Cristina Munerato
Diamond-Blackfan Anemia (DBA) is a rare heterogeneous genetic disease characterized by severe anemia, reduction or absence of erythroid progenitors, and pro-apoptoptic hematopoiesis, which culminates in bone marrow failure. The disease generally manifests in infancy, as craniofacial, cardiac, genitourinary, and upper limb congenital anomalies. Therapy with corticoids is the treatment of choice, while blood transfusion is adopted during diagnosis and as a chronic approach if the patient does not respond to corticoids...
June 2016: Clinical Medicine & Research
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