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Journal of the Chinese Medical Association: JCMA

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https://www.readbyqxmd.com/read/29748075/protective-effect-of-calcitriol-on-podocytes-in-spontaneously-hypertensive-rat
#1
Weiwei Shi, Ling Guo, Guangyi Liu, Tao Peng, Hongyu Li, Tingting Xie, Dengren Li, Junhui Zhen, Yan Wang, Huimin Yang, Xiangdong Yang
BACKGROUND: Hypertension is a major global public health issue. Uncontrolled hypertension leads to organ damage, especially renal damage. Calcitriol is used to treat osteoporosis, promote bone formation, and increase bone mass. Previous studies have demonstrated that 1,25(OH)2D3, in addition to its classic role, also has multiple immune regulation and renoprotective functions and inhibits the activity of the renin-angiotensin-aldosterone system (RASS). The aim of the current study was to investigate the renoprotective effects of calcitriol in a spontaneously hypertensive rat (SHR) model...
May 7, 2018: Journal of the Chinese Medical Association: JCMA
https://www.readbyqxmd.com/read/29709560/contributing-factors-to-mortality-rates-of-pulmonary-tuberculosis-in-intensive-care-units
#2
Dursun Tatar, Gunes Senol, Cenk Kirakli, Ozlem Edipoglu, Pinar Cimen
BACKGROUND: Tuberculosis (TB) remains an important health problem worldwide. TB patients sometimes require intensive care unit (ICU) treatment. The aim of this study is to establish special features and mortality rates of pulmonary TB patients in ICUs and identify the factors contributing to ICU mortality. METHODS: Medical records of adult patients (>18 years) with a diagnosis of TB who were admitted to the ICU of a referral hospital for chest diseases between 2004 and 2010 were reviewed retrospectively...
April 27, 2018: Journal of the Chinese Medical Association: JCMA
https://www.readbyqxmd.com/read/29703517/the-prognostic-value-of-gray-white-matter-ratio-on-brain-computed-tomography-in-adult-comatose-cardiac-arrest-survivors
#3
Gan-Nan Wang, Xu-Feng Chen, Jin-Ru Lv, Na-Na Sun, Xiao-Quan Xu, Jin-Song Zhang
BACKGROUND: Recent studies suggested that the gray-white matter ratio (GWR) determined from brain computed tomography (CT) scans may be a reliable predictor of poor neurological outcomes. The aim of study was to evaluate the association between the GWR and the outcomes in adult comatose cardiac arrest (CA) survivors in Chinese. METHODS: A total of 58 CA patients who had CT scans within 72 h of resuscitation between January 2011 and December 2015 were included in this single-center retrospective study...
April 25, 2018: Journal of the Chinese Medical Association: JCMA
https://www.readbyqxmd.com/read/29699783/is-it-really-risky-for-postpartum-stress-urinary-incontinence-in-the-first-year-postpartum
#4
LETTER
Yiu-Tai Li, Wen-Ling Lee
No abstract text is available yet for this article.
April 24, 2018: Journal of the Chinese Medical Association: JCMA
https://www.readbyqxmd.com/read/29685721/analysis-of-whole-genome-wide-methylation-and-gene-expression-profiles-in-visceral-omental-adipose-tissue-of-pregnancies-with-gestational-diabetes-mellitus
#5
Xingli Deng, Yulin Yang, Hao Sun, Wenjin Qi, Yong Duan, Yuan Qian
BACKGROUND: DNA methylation is the most extensively studied epigenetic modification which had been suspected to be involved in the progress of gestational diabetes mellitus(GDM). It is vital to investigate the expression profile and methylation profile in the GDM adipose tissue samples to learn more about the relationship between the two profiles. METHODS: Illumina Human Methylation 450 k DNA Analysis Beadchip and whole Human Gene Expression Array were selected to screen for methylation and gene expression in the omental visceral adipose tissue of pregnant women...
April 20, 2018: Journal of the Chinese Medical Association: JCMA
https://www.readbyqxmd.com/read/29656922/complete-and-thorough-evaluation-is-critical-for-the-initiation-of-surgery-in-the-management-of-women-with-pelvic-floor-disorders
#6
EDITORIAL
Chia-Pei Chang, Huann-Cheng Horng, Peng-Hui Wang
No abstract text is available yet for this article.
April 12, 2018: Journal of the Chinese Medical Association: JCMA
https://www.readbyqxmd.com/read/29650417/%C3%AE-aminoisobutyric-acid-accelerates-the-proliferation-and-differentiation-of-mc3t3-e1-cells-via-moderate-activation-of-ros-signaling
#7
Xiao-Wen Zhu, Kai Ding, Xiao-Yu Dai, Wei-Qi Ling
BACKGROUD: Osteoporosis is one of the bone-metabolic diseases associated with decreased bone renewal and bone mineral density. β-aminoisobutyric acid (BAIBA), a natural thymine catabolite, can reduce inflammation in skeletal muscle and alleviate hepatic endoplasmic reticulum stress. However, the roles of BAIBA in osteoblast proliferation and differentiation remain largely unknown. METHODS: The cultured MC3T3-E1 cells received various treatments in this study, including BAIBA alone, H2 O2 alone, BAIBA plus N-acetyl-l-cysteine and BAIBA plus apocynin...
April 9, 2018: Journal of the Chinese Medical Association: JCMA
https://www.readbyqxmd.com/read/29636231/the-clinical-impact-of-the-novel-tumor-marker-dr-70-in-unresectable-gastric-cancer-patients
#8
Yi-Ping Hung, Ming-Huang Chen, June-Seng Lin, Chin-Fu Hsiao, Yan-Shen Shan, Yeu-Chin Chen, Li-Tzong Chen, Tsang-Wu Liu, Chung-Pin Li, Yee Chao
BACKGROUND: Gastric cancer tumor markers, such as carcinoembryonic antigen (CEA) and cancer antigen 19-9 (CA 19-9), have been applied in clinical practice to screen or monitor treatment responses. However, their sensitivity and specificity are unsatisfactory. Therefore, we assessed the novel tumor marker DR-70 and evaluated its performance in screening and response monitoring. METHODS: The study included newly diagnosed patients with advanced gastric cancer from March 2012 to October 2015...
April 7, 2018: Journal of the Chinese Medical Association: JCMA
https://www.readbyqxmd.com/read/29636230/anti-apoptotic-effect-of-suxiao-jiuxin-pills-against-hypoxia-induced-injury-through-pi3k-akt-gsk3%C3%AE-pathway-in-hl-1-cardiomyocytes
#9
Yiping Li, Xiaofen Ruan, Tiejun Chen, Junjie Gao, Xiaolong Wang
BACKGROUND: Suxiao Jiuxin Pill (SX), Chinese traditional medicine primarily consisting of tetramethylpyrazine and borneol, has been shown to protect against ischemic heart diseases. Nevertheless, the involved mechanism still remains unclear. The following study aimed to investigate the potential protective effect and molecular mechanisms of SX on apoptosis in HL-1 cardiomyocytes. METHODS: Simulated hypoxia was established by culturing HL-1 cardiomyocytes in DMEM with no glucose or serum in a hypoxic chamber with 95% N2 and 5% CO2 for 24 h...
April 7, 2018: Journal of the Chinese Medical Association: JCMA
https://www.readbyqxmd.com/read/29625801/alveolar-soft-part-sarcoma-clinical-presentation-treatment-and-outcome-in-a-series-of-13-patients
#10
Yu-Kuan Lin, Po-Kuei Wu, Cheng-Fong Chen, Chao-Ming Chen, Shang-Wen Tsia, Paul Chih-Hsueh Chen, Wei-Ming Chen
BACKGROUND: Alveolar soft part sarcoma (ASPS) is a rare soft tissue tumor that typically affects young patients. Similar to other soft tissue sarcomas, it has high pulmonary metastasis ability, whereas compared with other soft tissue sarcomas, it has high brain metastasis ability. Because of the rarity of the disease, most studies on ASPS have been case reports and small series studies. METHOD: We performed a retrospective study to evaluate the clinical and pathological features and oncological results in a consecutive series of patients with localized or metastatic ASPS treated at our institute between 1994 and 2014...
April 3, 2018: Journal of the Chinese Medical Association: JCMA
https://www.readbyqxmd.com/read/29555445/influence-of-nanoparticle-size-on-the-skin-penetration-skin-retention-and-anti-inflammatory-activity-of-non-steroidal-anti-inflammatory-drugs
#11
Junko Yokota, Shojiro Kyotani
BACKGROUND: This study aims to evaluate the influence of nanoparticle size on the in vitro percutaneous penetration and retention and in vivo anti-inflammatory efficacy of percutaneously delivered non-steroidal anti-inflammatory drugs. METHODS: Indomethacin, ketoprofen and piroxicam were incorporated into nanoparticles. The nanoparticles, or the bulk-drug equivalents, were suspended in a hydrophilic ointment and compared for their ability to facilitate percutaneous drug penetration and retention in vitro...
March 16, 2018: Journal of the Chinese Medical Association: JCMA
https://www.readbyqxmd.com/read/29551488/bi-directional-solid-fermentation-products-of-trametes-robiniophila-murr-with-radix-isatidis-inhibit-proliferation-and-metastasis-of-breast-cancer-cells
#12
Ziyao Liu, Yun Tang, Rongrong Zhou, Xiaosa Shi, Hongmei Zhang, Tengfei Liu, Zenglin Lian, Xinyuan Shi
BACKGROUND: The bi-directional solid fermentation product extract of Trametes robiniophila Murr (Huaier) with Radix Isatidis (TIF) has been shown to have good anti-tumor activity. However, the mechanisms of this activity are still unknown. In the present study, we aimed to investigate its inhibitory effect on both SK-BR-3 and MDA-MB-231 cells, and explore the possible mechanisms of its anti-cancer effect in vitro. METHODS: The experiment comprised a control group, Radix Isatidis group, Huaier group, and TIF group...
March 15, 2018: Journal of the Chinese Medical Association: JCMA
https://www.readbyqxmd.com/read/29551487/left-atrial-function-inflammation-and-prothrombotic-response-after-radiofrequency-ablation-for-atrial-fibrillation
#13
Guangli Yin, Ruiqin Xie, Ling You, Hongning Yin, Yucui Sun, Jinglan Wu, Yansha Zhao, Xue Geng, Yanan Zhang
BACKGROUND: The conversion of atrial fibrillation (AF) to sinus rhythm is associated with transient dysfunction of the left atrium (LA). This study aimed to investigate the time course of LA function and inflammation after radiofrequency (RF) ablation for paroxysmal AF. METHODS: Fifty-three patients with paroxysmal AF undergoing RF ablation were recruited. White blood cells were counted and high-sensitivity C-reactive protein (hs-CRP), fibrinogen, and D-dimer levels were measured...
March 15, 2018: Journal of the Chinese Medical Association: JCMA
https://www.readbyqxmd.com/read/29551486/parathyroid-hormone-gene-activated-matrix-with-dfdba-collagen-composite-matrix-enhances-bone-regeneration-in-rat-calvarial-bone-defects
#14
Po-Hui Lee, Tu-Lai Yew, Yu-Lin Lai, Shyh-Yuan Lee, Hen-Li Chen
BACKGROUND: Gene-activated matrix (GAM) induces sustained local production of growth factors to promote tissue regeneration. GAM contains a plasmid DNA (pDNA) encoding target proteins that is physically entrapped within a biodegradable matrix carrier. GAM with a pDNA encoding the first 34 amino acids of parathyroid hormone (PTH 1-34) and a collagen matrix enhances bone regeneration in long bone defects. Demineralized freeze-dried bone allograft (DFDBA) is a widely used osteoinductive bone graft...
March 15, 2018: Journal of the Chinese Medical Association: JCMA
https://www.readbyqxmd.com/read/29551485/the-perioperative-outcomes-between-renal-hilar-and-non-hilar-tumors-following-robotic-assisted-partial-nephrectomy-rapn
#15
Shih-Yen Lu, Hsiao-Jen Chung, Eric Yi-Hsiu Huang, Tzu-Pin Lin, Alex T L Lin
BACKGROUND: The aim of this study was to compare the perioperative outcomes between renal hilar tumors and non-hilar tumors after robotic-assisted partial nephrectomy (RAPN). METHODS: A retrospective review of consecutive patients who underwent RAPN from December 2009 to September 2015 at our institution was recruited. Perioperative outcomes including demographic characteristics, perioperative, pathological and renal function outcomes were compared between the hilar group (n = 30) and non-hilar group (n = 170)...
March 15, 2018: Journal of the Chinese Medical Association: JCMA
https://www.readbyqxmd.com/read/29551484/trend-of-seizure-remission-in-patients-with-tuberous-sclerosis-complex-a-retrospective-medical-review
#16
Chang-Ching Wei, Ji-Nan Sheu, Jung-Tung Liu, Sheng-Hui Yang, I-Ching Chou, Jeng-Dau Tsai
BACKGROUND: Seizures in tuberous sclerosis complex (TSC) tend to be intractable over time and become a subsequent psychological burden for the patients. The purpose of the current study was to describe the onset, phenotype, and factors associated with seizure remission in patients with TSC. METHODS: Patients diagnosed with TSC between 2009 and 2015 completed a questionnaire interview and underwent a systematic evaluation, including a medical review of their epilepsy history and neurobehavioral disorder assessment...
March 15, 2018: Journal of the Chinese Medical Association: JCMA
https://www.readbyqxmd.com/read/29548936/evaluation-of-prescription-errors-and-prescribing-indicators-in-the-private-practices-in-bahawalpur-pakistan
#17
Muhammad Atif, Muhammad Azeem, Muhammad Rehan Sarwar, Iram Malik, Wajiha Ahmad, Fariha Hassan, Ayesha Rehman, Mahjabeen Rana
BACKGROUND: Appropriate use of medicines is important to provide quality health. The aim of this study was to assess the prescribing practices and prescription errors in the private clinic practices of Bahawalpur, Pakistan. METHODS: A cross-sectional observational study was performed in March 2015 to assess the prescribing practices and prescription errors in the private clinical practices of Bahawalpur, Pakistan. We used the standard World Health Organization (WHO) methodology to achieve the study objectives...
March 13, 2018: Journal of the Chinese Medical Association: JCMA
https://www.readbyqxmd.com/read/29428319/characterization-and-functional-correlation-of-multiple-imaging-modalities-with-focal-choroidal-excavation
#18
Yun-Chen Chen, Yu-Bai Chou, Cheng-Kuan Lin, Chia-Chen Tsai, Tsui-Kang Hsu, Yu-Fan Chang, Hsiao-Ming Chao, Tao-Hsin Tung, Shih-Jen Chen, Jorn-Hon Liu
BACKGROUND: To investigate the clinical manifestations and imaging features of near-infrared autofluorescence (NIA), infrared reflectance (IR), fundus autofluorescence (FAF), indocyanine green angiography (ICGA) and fluorescein angiography (FAG) in the detection of patients with focal choroidal excavation (FCE) identified by cross-sectional spectral-domain optical coherence tomography (SD-OCT). METHODS: This retrospective cross-sectional study included 12 eyes of 10 Taiwanese patients with FCE diagnosed by SD-OCT...
May 2018: Journal of the Chinese Medical Association: JCMA
https://www.readbyqxmd.com/read/29503127/constitution-of-traditional-chinese-medicine-and-related-factors-in-women-of-childbearing-age
#19
Qiao-Yu Jiang, Jue Li, Liang Zheng, Guang-Hua Wang, Jing Wang
BACKGROUND: This study investigates the constitution of traditional Chinese medicine (TCM) among women who want to be pregnant in one year and explores factors related to TCM constitution. METHODS: This study was conducted on women who participated in free preconception check-ups provided by the Zhabei District Maternity and Child Care Center in Shanghai, China. The information regarding the female demographic characteristics, physical condition, history of pregnancy and childbearing, diet and behavior, and social psychological factors was collected, and TCM constitution assessment was performed...
April 2018: Journal of the Chinese Medical Association: JCMA
https://www.readbyqxmd.com/read/29499900/does-preserved-sphincter-of-oddi-function-prevent-common-bile-duct-stones-recurrence-in-patients-after-endoscopic-papillary-balloon-dilation
#20
Tzung-Jiun Tsai, Chiun-Ku Lin, Kwok-Hung Lai, Hoi-Hung Chan, E-Ming Wang, Wei-Lun Tsai, Jin-Shiung Cheng, Hsien-Chung Yu, Wen-Chi Chen, Ping-I Hsu
BACKGROUND: Whether preserving sphincter of Oddi (SO) function by endoscopic papillary balloon dilation (EPBD) is beneficial for preventing recurrent common bile duct stone disease (CBDS) is controversial. The aim of this study was to measure sphincter of Oddi (SO) function by using SO manometry, and to evaluate the association with recurrent CBDS. METHODS: Patients with suspected CBDS who underwent successful EPBD were included. These patients underwent SO manometry at two months after EPBD with bile duct clearance...
April 2018: Journal of the Chinese Medical Association: JCMA
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