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World Journal of Surgical Oncology

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https://www.readbyqxmd.com/read/28327197/lipid-raft-mediated-mir-3908-inhibition-of-migration-of-breast-cancer-cell-line-mcf-7-by-regulating-the-interactions-between-adipor1-and-flotillin-1
#1
Yuan Li, Fei Shan, Jinglong Chen
BACKGROUND: The mechanisms of lipid raft regulation by microRNAs in breast cancer are not fully understood. This work focused on the evaluation and identification of miR-3908, which may be a potential biomarker related to the migration of breast cancer cells, and elucidates lipid-raft-regulating cell migration in breast cancer. METHODS: To confirm the prediction that miR-3908 is matched with AdipoR1, we used 3'-UTR luciferase activity of AdipoR1 to assess this. Then, human breast cancer cell line MCF-7 was cultured in the absence or presence of the mimics or inhibitors of miR-3908, after which the biological functions of MCF-7 cells were analyzed...
March 21, 2017: World Journal of Surgical Oncology
https://www.readbyqxmd.com/read/28327158/the-clinicopathological-parameters-and-prognostic-significance-of-her2-expression-in-gastric-cancer-patients-a-meta-analysis-of-literature
#2
REVIEW
Yu-Ying Lei, Jin-Yu Huang, Qiong-Rui Zhao, Nan Jiang, Hui-Mian Xu, Zhen-Ning Wang, Hai-Qing Li, Shi-Bo Zhang, Zhe Sun
BACKGROUND: Human epidermal growth factor receptor-2 (HER2) is regarded as an important and promising target in the treatment of HER2-positive breast cancers. However, the correlation of clinicopathological characteristics and prognostic significance of HER2 overexpression in gastric cancer patients remains unclear. Our aim was to clarify this issue. METHODS: Embase, PubMed, and the Cochrane Library were searched for relevant articles published up to May 2016. Outcomes of interest contained sex, age, tumor size, tumor site, tumor node metastasis (TNM) stage, distant metastasis, lymph node metastasis, Lauren's classification, differentiation grade, lymphovascular invasion, neural invasion, and multivariate analysis data for overall survival...
March 21, 2017: World Journal of Surgical Oncology
https://www.readbyqxmd.com/read/28320475/decreased-expression-of-semaphorin-3d-is-associated-with-genesis-and-development-in-colorectal-cancer
#3
Zhen Wang, Meiman Ding, Naiying Qian, Beifeng Song, Jiayin Yu, Jinlong Tang, Jingyu Wang
BACKGROUND: Semaphorin 3D (SEMA3D) plays important roles in the genesis and progress of many cancers. However, the relationship between SEMA3D and colorectal cancer (CRC) remains unknown. The aim of this study was to investigate whether SEMA3D can be used as a predictive marker for the diagnosis, metastasis, and prognosis of CRC by assessing the expression of SEMA3D in the tissues and serum of CRC patients. METHODS: Real-time quantitative polymerase chain reaction (qPCR) was used to measure the expression of SEMA3D mRNA in 100 CRC tissues and matched normal tissues...
March 20, 2017: World Journal of Surgical Oncology
https://www.readbyqxmd.com/read/28320388/exploring-the-fgfr3-related-oncogenic-mechanism-in-bladder-cancer-using-bioinformatics-strategy
#4
Wei Cao, Enguang Ma, Li Zhou, Tan Yuan, Chunying Zhang
BACKGROUND: Aberrant activation of fibroblast growth factor receptor 3 (FGFR3) is frequently observed in bladder cancer, but how it involved in carcinogenesis is not well understood. The current study was aimed to investigate the underlying mechanism on the progression of bladder cancer. METHODS: The GSE41035 dataset downloaded from Gene Expression Omnibus was used to identify the differentially expressed genes (DEGs) between bladder cancer cell line RT112 with or without depletion of FGFR3, and gene ontology enrichment analysis was performed...
March 20, 2017: World Journal of Surgical Oncology
https://www.readbyqxmd.com/read/28302176/association-of-lymph-node-involvement-with-the-prognosis-of-pathological-t1-invasive-non-small-cell-lung-cancer
#5
Yong-Kui Zhang, Zheng-da Chai, Lin-Lin Tan, Zhao-Yu Wang, Zhi-Jun Chen, Han-Bo Le, Wang-Yu Zhu
BACKGROUND: Lymph node involvement could help to predict the prognosis of pathological T1 (pT1, diameters of ≤3 cm) non-small cell lung cancer (NSCLC). This study assessed the clinicopathological factors and associated lymph node involvement in invasive lung adenocarcinoma (IAC) and squamous cell lung cancer (SCC) and the overall and disease-free survival associated with these factors. METHODS: Three hundred and twenty-five patients with pathological T1 NSCLC (253 IAC and 72 SCC) were retrospectively analyzed from a pool of 1094 primary lung cancer patients...
March 17, 2017: World Journal of Surgical Oncology
https://www.readbyqxmd.com/read/28302173/squamous-cell-carcinoma-arising-from-chronic-sacrococcygeal-pilonidal-disease-a-case-report
#6
Nick Michalopoulos, Konstantinos Sapalidis, Styliani Laskou, Evangelia Triantafyllou, Georgia Raptou, Isaak Kesisoglou
BACKGROUND: Sacrococcygeal pilonidal disease is a chronic, well-recognized entity, characterized by the recurrent formation of an abscess or draining sinus over the sacrococcygeal area. It is one of the most common surgical problems. Rarely, chronic inflammation and recurrent disease leads to malignant transformation, most commonly to squamous cell carcinoma (SCC). CASE PRESENTATION: We describe an extremely unusual case of SCC developing in a 60-year-old patient with a chronic pilonidal sinus complicated by an anal fistula...
March 17, 2017: World Journal of Surgical Oncology
https://www.readbyqxmd.com/read/28302162/total-thyroidectomy-may-be-more-reasonable-as-initial-surgery-in-unilateral-multifocal-papillary-thyroid-microcarcinoma-a-single-center-experience
#7
Shuai Xue, Peisong Wang, Jia Liu, Guang Chen
BACKGROUND: The extent of surgery in patients with unilateral multifocal papillary thyroid microcarcinoma (UMPTMC) remains to be controversial. Aimed to improve surgical management of UMPTMC, this study was performed to identify the recurrence of UMPTMC and analyze its predictive factors. METHODS: This study was approved by the Ethical Committee of The First Hospital of the Jilin University, and written informed consent was given by participants for their clinical records to be used in this study...
March 16, 2017: World Journal of Surgical Oncology
https://www.readbyqxmd.com/read/28302149/identification-and-interaction-analysis-of-key-genes-and-micrornas-in-hepatocellular-carcinoma-by-bioinformatics-analysis
#8
Tong Mou, Di Zhu, Xufu Wei, Tingting Li, Daofeng Zheng, Junliang Pu, Zhen Guo, Zhongjun Wu
BACKGROUND: Hepatocellular carcinoma (HCC) is the most common liver malignancy worldwide. However, present studies of its multiple gene interaction and cellular pathways still could not explain the initiation and development of HCC perfectly. To find the key genes and miRNAs as well as their potential molecular mechanisms in HCC, microarray data GSE22058, GSE25097, and GSE57958 were analyzed. METHODS: The microarray datasets GSE22058, GSE25097, and GSE57958, including mRNA and miRNA profiles, were downloaded from the GEO database and were analyzed using GEO2R...
March 16, 2017: World Journal of Surgical Oncology
https://www.readbyqxmd.com/read/28302122/incidence-and-risk-factors-of-inguinal-hernia-after-robot-assisted-radical-prostatectomy
#9
Yuta Yamada, Tetsuya Fujimura, Hiroshi Fukuhara, Toru Sugihara, Kotaro Takemura, Shigenori Kakutani, Motofumi Suzuki, Tohru Nakagawa, Haruki Kume, Yasuhiko Igawa, Yukio Homma
BACKGROUND: Robot-assisted radical prostatectomy (RARP) has now become a gold standard approach in radical prostatectomy. The aim of this study was to investigate incidence and risk factors of inguinal hernia (IH) after RARP. METHODS: This study included 307 consecutive men who underwent RARP for the treatment of prostate cancer from January 2011 to August 2015. The incidence of IH after RARP was investigated. Clinical and pathological factors were also investigated to assess relationship with development of postoperative IH...
March 16, 2017: World Journal of Surgical Oncology
https://www.readbyqxmd.com/read/28292293/batwing-versus-wise-pattern-mammoplasty-for-upper-pole-breast-tumours-a-detailed-comparison-of-cosmetic-outcome
#10
Tarek Hashem, Ahmed Farahat
BACKGROUND: The aim of this study is to compare the results of batwing mammoplasty and Wise pattern mammoplasty in the surgical management of upper pole breast tumours. METHODS: This is a retrospective observational study including 126 breast cancer patients who presented between 2009 and 2015 to the National Cancer Institute of Cairo University in Egypt. All patients were candidates for breast conservation, with upper pole tumours, which was defined as tumours between 3 and 9 o'clock...
March 14, 2017: World Journal of Surgical Oncology
https://www.readbyqxmd.com/read/28284210/prognostic-factors-for-gastrectomy-in-elderly-patients-with-gastric-cancer
#11
Daisuke Ueno, Hideo Matsumoto, Hisako Kubota, Masaharu Higashida, Takashi Akiyama, Akiko Shiotani, Toshihiro Hirai
BACKGROUND: The aim of the present study was to investigate the age-specific prognostic factors in patients who underwent gastrectomy for gastric cancer. METHODS: The medical records of 366 patients with gastric cancer who underwent surgical resection at our hospital between January 2007 and December 2014 were retrospectively reviewed. Of the 366 patients, 117 were aged 75 years or older and 249 were aged 74 years or younger. All factors that were identified as significant using univariate analysis were included in the multivariate analysis...
March 11, 2017: World Journal of Surgical Oncology
https://www.readbyqxmd.com/read/28279206/mastalgia-as-an-atypical-presentation-of-hepatocellular-carcinoma-a-case-report
#12
AbdulAziz Mohammad Al-Sharydah, Abdulrhman Hamad Al-Abdulwahhab, Ibrahim Abobaker Alghnimi, Mohammed A El Shawarby, Faisal Ahmad Katbi
BACKGROUND: As the incidence of hepatocellular carcinoma (HCC) diagnoses in Saudi Arabia has recently increased due to better diagnostic techniques, the incidence of diagnosed HCC metastasis has also increased. Here, we report a case of HCC metastasis to the rib with an initially atypical presentation of mastalgia caused by extrahepatic metastasis. CASE PRESENTATION: A 31-year-old woman with a prior hepatitis B viral infection presented with a mass in the left breast accompanied by mastalgia for a 6-month duration...
March 9, 2017: World Journal of Surgical Oncology
https://www.readbyqxmd.com/read/28270160/alpps-associating-liver-partition-and-portal-vein-ligation-for-staged-hepatectomy-does-not-affect-proliferation-apoptosis-or-angiogenesis-as-compared-to-standard-liver-resection-for-colorectal-liver-metastases
#13
Katharina Joechle, Christian Moser, Petra Ruemmele, Katharina M Schmidt, Jens M Werner, Edward K Geissler, Hans J Schlitt, Sven A Lang
BACKGROUND: ALPPS (associating liver partition and portal vein ligation for staged hepatectomy) is a novel two-stage strategy to induce rapid hypertrophy of the future liver remnant (FLR) when patients are in danger of postoperative liver failure due to insufficient FLR. However, the effects of ALPPS on colorectal liver metastases (CRLM) are not clear so far. The aim of our study was to determine whether ALPPS induces proliferation, apoptosis, or vascularization compared to standard (one-stage) liver resection...
March 7, 2017: World Journal of Surgical Oncology
https://www.readbyqxmd.com/read/28270153/audit-of-mammography-requests-in-abakaliki-south-east-nigeria
#14
U E Eni, K C Ekwedigwe, I Sunday-Adeoye, Abc Daniyan, M E Isikhuemen
BACKGROUND: Breast cancer is the leading cancer in women in both developed and developing countries. Screening mammography detects breast cancer even before a lump can be palpated, with better prognosis. The introduction of mammographic technique for screening breast cancer, despite its importance, has been slow to adopt and virtually non-existent in many parts of Sub-Saharan Africa including Nigeria. For this reason, the indications of mammography have not been well defined in our setting...
March 7, 2017: World Journal of Surgical Oncology
https://www.readbyqxmd.com/read/28253871/relationship-between-egfr-gene-mutation-and-local-metastasis-of-resectable-lung-adenocarcinoma
#15
Yunqiang Nie, Wei Gao, Na Li, Wenjun Chen, Hui Wang, Cuiyun Li, Haiyan Zhang, Ping Han, Yingmei Zhang, Xin Lv, Xinyi Xu, Hongyan Liu
BACKGROUND: Resectable lung adenocarcinoma is dominated by peripheral distribution, and surgical resection is the main treatment protocol. However, high recurrence rate remains after surgery. Lung adenocarcinoma with epidermal growth factor receptor (EGFR) mutation has strong invasion ability, but the effects of this mutation on local invasion in early lung adenocarcinoma have been rarely studied. This study aimed to assess the effects of EGFR mutation on local invasion in resectable lung adenocarcinoma...
March 3, 2017: World Journal of Surgical Oncology
https://www.readbyqxmd.com/read/28253875/the-interval-approach-an-adaptation-of-the-liver-first-approach-to-treat-synchronous-liver-metastases-from-rectal-cancer
#16
Mathieu D'Hondt, Valerio Lucidi, Koen Vermeiren, Bert Van Den Bossche, Vincent Donckier, Gregory Sergeant
BACKGROUND: The waiting interval after chemoradiotherapy (CRT) is an interesting therapeutic window to treat patients with synchronous liver metastases (SLM) from rectal cancer. METHODS: A retrospective analysis was performed of 18 consecutive patients (M/F 10/8, age (range) 60 (51-75) years) from five institutions who underwent liver resection of SLM during the waiting interval after CRT for rectal adenocarcinoma. RESULTS: All patients underwent interval liver surgery for a median (range) of 4 (2-14) liver metastases...
March 2, 2017: World Journal of Surgical Oncology
https://www.readbyqxmd.com/read/28245846/surgical-strategy-of-bilateral-synchronous-sporadic-renal-cell-carcinoma-experience-of-a-chinese-university-hospital
#17
Xiao-Yi Hu, Lei Xu, Jian-Ming Guo, Hang Wang
BACKGROUND: The objective of this study is to investigate the optimal therapeutic protocol for BSSRCC. METHODS: A total of 32 BSSRCC patients, including 28 males and 4 females, were enrolled the study from January 2004 to May 2016. The diagnoses were defined by the measurements of CT, ultrasound, and MRI. Patients with hereditary syndrome were excluded. The management of surgical manner, operation staging, and sequence were scheduled in accordance with the tumor's location and size (based on Zhongshan score, ZS score), as well as the performance status of the patients...
February 28, 2017: World Journal of Surgical Oncology
https://www.readbyqxmd.com/read/28228146/body-mass-index-bmi-may-be-a-prognostic-factor-for-gastric-cancer-with-peritoneal-dissemination
#18
Shi Chen, Run-Cong Nie, Li-Ying OuYang, Yuan-Fang Li, Jun Xiang, Zhi-Wei Zhou, YingBo Chen, JunSheng Peng
BACKGROUND: The aim of this study is to investigate whether body mass index (BMI) is a prognostic factor in gastric cancer patients with peritoneal dissemination. METHODS: This is a retrospective study consisting of 518 patients with a histological diagnosis of gastric cancer with peritoneal dissemination seen at the Sixth Affiliated Hospital of Sun Yat-Sen University and Sun Yat-sen University Cancer Center between January 2010 and April 2014. Patients were followed until December 2015...
February 23, 2017: World Journal of Surgical Oncology
https://www.readbyqxmd.com/read/28222738/are-there-intra-operative-hemodynamic-differences-between-the-coliseum-and-closed-hipec-techniques-in-the-treatment-of-peritoneal-metastasis-a-retrospective-cohort-study
#19
Cristina Rodríguez Silva, Francisco Javier Moreno Ruiz, Inmaculada Bellido Estévez, Joaquin Carrasco Campos, Alberto Titos García, Manuel Ruiz López, Ivan González Poveda, Jose Antonio Toval Mata, Santiago Mera Velasco, Julio Santoyo Santoyo
BACKGROUND: Although two main methods of intraoperative hyperthermic intraperitoneal chemotherapy (HIPEC) are currently accepted, the superiority of one over the other has not yet been demonstrated. The purpose of this study was to determine whether there are hemodynamic and temperature differences between patients who received HIPEC in two different techniques, open versus closed abdomen. METHODS: This retrospective study was conducted in our center between 2011-2015 in 30 patients who underwent surgery for peritoneal carcinomatosis secondary to colorectal cancer, in whom cytoreduction and HIPEC were performed by the Coliseum (15) or closed techniques (15)...
February 21, 2017: World Journal of Surgical Oncology
https://www.readbyqxmd.com/read/28222734/diabetes-and-beta-adrenergic-blockage-are-risk-factors-for-metastatic-prostate-cancer
#20
Malte Krönig, Christian Haverkamp, Antonia Schulte, Laura Heinicke, Kathrin Schaal, Vanessa Drendel, Martin Werner, Ulrich Wetterauer, Wolfgang Schultze-Seemann, Cordula Annette Jilg
BACKGROUND: We evaluated the influence of comorbidity inferred risks for lymph node metastasis (pN1) and positive surgical margins (R1) after radical prostatectomy in order to optimize pretherapeutic risk classification. We analyzed 454 patients after radical prostatectomy (RP) between 2009 and 2014. Comorbidities were defined by patients' medication from our electronic patient chart and stratified according to the ATC WHO code. Endpoints were lymph node metastasis (pN1) and positive surgical margins (R1)...
February 21, 2017: World Journal of Surgical Oncology
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