Hong Loan Ngo, Thuc Quyen Huynh, Nguyen Bao Vy Tran, Ngoc Hoa Binh Nguyen, Thi Hang Tong, Thi Truc Ly Trinh, Van Dung Nguyen, Prem Prakash Das, Teck Kwang Lim, Qingsong Lin, Thi Thu Hoai Nguyen
BACKGROUND: Pseudomonas aeruginosa is well known for its intrinsic ability to resist a wide range of antibiotics, thus complicates treatment. Thus, understanding the response of the pathogen to antibiotics is important for developing new therapies. In this study, proteomic response of P. aeruginosa to the commonly used anti-pseudomonas antibiotics, ceftazidime (Caz) and meropenem (Mem) was investigated. METHODS: P. aeruginosa ATCC 9027, an antibiotic-susceptible strain, was exposed to sub-MIC values of antibiotics either Caz or Mem for 14 days to obtain E1 strains and then cultured in antibiotic-free environments for 10 days to obtain E2 strains...
September 28, 2023: Proteome Science