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Cell Communication and Signaling: CCS

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https://www.readbyqxmd.com/read/29783989/high-co-expression-of-the-sdf1-cxcr4-axis-in-hepatocarcinoma-cells-is-regulated-by-annexina7-in-vitro-and-in-vivo
#1
Jingwen Wang, Yuhong Huang, Jun Zhang, Boyi Xing, Wei Xuan, Honghai Wang, He Huang, Jiayu Yang, Jianwu Tang
BACKGROUND: SDF1/CXCR4 and AnnexinA7 play important roles in many physiological and pathological conditions, but the molecular association between them in cancer cells has not been studied thus far. METHODS: The expression changes of SDF1/CXCR4 were detected by gene transcriptome sequencing, qRT-PCR, Western blotting, cytoimmunofluorescence and immunohistochemistry in mouse hepatocarcinoma F/P cells, AnnexinA7 downregulated expression F (FA7DOWN ) cells, AnnexinA7 overexpression P (PA7UP ) cells, AnnexinA7 unrelated sequence F (FSHUS ) cells, empty vector P (PNCEV ) cells and normal liver cells in vitro and in vivo...
May 21, 2018: Cell Communication and Signaling: CCS
https://www.readbyqxmd.com/read/29776413/the-cxcr4-antagonist-plerixafor-amd3100-promotes-proliferation-of-ewing-sarcoma-cell-lines-in-vitro-and-activates-receptor-tyrosine-kinase-signaling
#2
Philipp Berning, Christiane Schaefer, Dagmar Clemens, Eberhard Korsching, Uta Dirksen, Jenny Potratz
BACKGROUND: The CXCR4 receptor antagonist plerixafor (AMD3100) is raising interest as an anti-cancer agent that disrupts the CXCL12-CXCR4 chemokine - receptor interaction between neoplastic cells and their microenvironment in tumor progression and metastasis. Here, we investigated plerixafor for anti-cancer activity in Ewing sarcoma, a rare and aggressive cancer of bone and soft tissues. METHODS: We used a variety of methods such as cell viability and migration assays, flow cytometry, phospho-tyrosine arrays and western blotting to determine plerixafor effects on five characterized Ewing sarcoma cell lines and a low-passage culture in vitro...
May 18, 2018: Cell Communication and Signaling: CCS
https://www.readbyqxmd.com/read/29716651/overexpressed-hdac8-in-cervical-cancer-cells-shows-functional-redundancy-of-tubulin-deacetylation-with-hdac6
#3
G R Vanaja, Hemalatha Golaconda Ramulu, Arunasree M Kalle
BACKGROUND: Histone deacetylases (HDACs) are involved in epigenetic gene regulation via deacetylation of acetylated lysine residues of both histone and non-histone proteins. Among the 18 HDACs identified in humans, HDAC8, a class I HDAC, is best understood structurally and enzymatically. However, its precise subcellular location, function in normal cellular physiology, its protein partners and substrates still remain elusive. METHODS: The subcellular localization of HDAC8 was studied using immunofluorescence and confocal imaging...
May 2, 2018: Cell Communication and Signaling: CCS
https://www.readbyqxmd.com/read/29703230/golgi-tethering-factor-golgin-97-suppresses-breast-cancer-cell-invasiveness-by-modulating-nf-%C3%AE%C2%BAb-activity
#4
Rae-Mann Hsu, Cai-Yan Zhong, Chih-Liang Wang, Wei-Chao Liao, Chi Yang, Shih-Yu Lin, Jia-Wei Lin, Hsiao-Yun Cheng, Po-Yu Li, Chia-Jung Yu
BACKGROUND: Golgin-97 is a tethering factor in the trans-Golgi network (TGN) and is crucial for vesicular trafficking and maintaining cell polarity. However, the significance of golgin-97 in human diseases such as cancer remains unclear. METHODS: We searched for a potential role of golgin-97 in cancers using Kaplan-Meier Plotter ( http://kmplot.com ) and Oncomine ( www.oncomine.org ) datasets. Specific functions of golgin-97 in migration and invasion were examined in golgin-97-knockdown and golgin-97-overexpressing cells...
April 27, 2018: Cell Communication and Signaling: CCS
https://www.readbyqxmd.com/read/29695252/yap-taz-regulates-tgf-%C3%AE-smad3-signaling-by-induction-of-smad7-via-ap-1-in-human-skin-dermal-fibroblasts
#5
Zhaoping Qin, Wei Xia, Gary J Fisher, John J Voorhees, Taihao Quan
BACKGROUND: Transcription factors YAP and TAZ function as the primary mediators of the Hippo pathway. Yet, crosstalk of YAP and TAZ with other signaling pathways remains relatively unexplored. We have explored the impact of YAP and TAZ levels on the TGF-β/Smad signaling pathway in human skin dermal fibroblasts. METHODS: YAP and TAZ levels in dermal fibroblasts were reduced in dermal fibroblasts by siRNA-mediated knockdown. The effects of YAP and TAZ reduction on TGF-β/Smad signaling were examined by quantitative real-time PCR, Western analysis, and immunostaining...
April 25, 2018: Cell Communication and Signaling: CCS
https://www.readbyqxmd.com/read/29690889/effect-of-colorectal-cancer-derived-extracellular-vesicles-on-the-immunophenotype-and-cytokine-secretion-profile-of-monocytes-and-macrophages
#6
Ineta Popēna, Artūrs Ābols, Līga Saulīte, Kārlis Pleiko, Elīna Zandberga, Kaspars Jēkabsons, Edgars Endzeliņš, Alicia Llorente, Aija Linē, Una Riekstiņa
BACKGROUND: Macrophages are one of the most important players in the tumor microenvironment. The polarization status of tumor associated macrophages into a pro-inflammatory type M1 or anti-inflammatory type M2 may influence cancer progression and patient survival. Extracellular vesicles (EVs) are membrane-bound vesicles containing different biomolecules that are involved in cell to cell signal transfer. Accumulating evidence suggests that cancer-derived EVs are taken up by macrophages and modulate their phenotype and cytokine profile...
April 24, 2018: Cell Communication and Signaling: CCS
https://www.readbyqxmd.com/read/29661252/mir-148b-3p-functions-as-a-tumor-suppressor-in-gists-by-directly-targeting-kit
#7
Yu Wang, Jun Li, Dong Kuang, Xiaoyan Wang, Yuanli Zhu, Sanpeng Xu, Yaobing Chen, Henghui Cheng, Qiu Zhao, Yaqi Duan, Guoping Wang
BACKGROUND: Gain-of-function mutations and overexpression of KIT are characteristic features of gastrointestinal stromal tumor (GIST). Dysregulation in miRNA expression may lead to KIT overexpression and tumorigenesis. METHODS: miRNA microarray analysis and real-time PCR were used to determine the miRNA expression profiles in a cohort of 69 clinical samples including 50 CD117IHC+ /KITmutation GISTs and 19 CD117IHC- /wild-type GISTs. GO enrichment and KEGG pathway analyses were performed to reveal the predicted targets of the dysregulated miRNAs...
April 16, 2018: Cell Communication and Signaling: CCS
https://www.readbyqxmd.com/read/29642895/wnt3a-ligand-facilitates-autophagy-in-hippocampal-neurons-by-modulating-a-novel-gsk-3%C3%AE-ampk-axis
#8
Juvenal A Ríos, Juan A Godoy, Nibaldo C Inestrosa
BACKGROUND: In the adult central nervous system (CNS), Wnt signaling regulates dendritic structure and synaptic plasticity. The Wnt signaling pathway can be divided into the canonical (β-catenin-dependent) and non-canonical pathways. In the canonical pathway, the binding of canonical ligands such as Wnt3a to the Frizzled receptor induces inactivation of glycogen synthase kinase-3β (GSK-3β), which stabilizes β-catenin and allows its translocation to the nucleus. However, to date, few studies have focused on β-catenin-independent Wnt signaling or explained the underlying mechanisms connecting Wnt signaling to cellular energy metabolism...
April 11, 2018: Cell Communication and Signaling: CCS
https://www.readbyqxmd.com/read/29636110/matrix-metalloproteinase-9-mmp9-is-involved-in-the-tnf-%C3%AE-induced-fusion-of-human-m13sv1-cre-breast-epithelial-cells-and-human-mda-mb-435-pfdr1-cancer-cells
#9
Julian Weiler, Marieke Mohr, Kurt S Zänker, Thomas Dittmar
BACKGROUND: In addition to physiological events such as fertilisation, placentation, osteoclastogenesis, or tissue regeneration/wound healing, cell fusion is involved in pathophysiological conditions such as cancer. Cell fusion, which applies to both the proteins and conditions that induce the merging of two or more cells, is not a fully understood process. Inflammation/pro-inflammatory cytokines might be a positive trigger for cell fusion. Using a Cre-LoxP-based cell fusion assay we demonstrated that the fusion between human M13SV1-Cre breast epithelial cells and human MDA-MB-435-pFDR1 cancer cells was induced by the pro-inflammatory cytokine tumour necrosis factor-α (TNF-α)...
April 10, 2018: Cell Communication and Signaling: CCS
https://www.readbyqxmd.com/read/29625612/interaction-between-human-osteosarcoma-and-mesenchymal-stem-cells-via-an-interleukin-8-signaling-loop-in-the-tumor-microenvironment
#10
Masanori Kawano, Kazuhiro Tanaka, Ichiro Itonaga, Tatsuya Iwasaki, Hiroshi Tsumura
BACKGROUND: Osteosarcoma (OS) is the representative primary malignant bone tumor with the highest incidence. It is known that malignant phenotypes of OS, such as proliferation, invasion, and metastasis, are significantly influenced not only by characteristics of the tumor itself, but also by the surrounding microenvironment. In other words, OS is considered to utilize cells in the vicinity of the tumor by changing the characteristics of these cells. Direct intercellular contact is believed to be important for this phenomenon...
April 6, 2018: Cell Communication and Signaling: CCS
https://www.readbyqxmd.com/read/29615051/the-nuclear-transportation-routes-of-membrane-bound-transcription-factors
#11
REVIEW
Yang Liu, Peiyao Li, Li Fan, Minghua Wu
Membrane-bound transcription factors (MTFs) are transcription factors (TFs) that are anchored in membranes in a dormant state. Activated by external or internal stimuli, MTFs are released from parent membranes and are transported to the nucleus. Existing research indicates that some plasma membrane (PM)-bound proteins and some endoplasmic reticulum (ER) membrane-bound proteins have the ability to enter the nucleus. Upon specific signal recognition cues, some PM-bound TFs undergo proteolytic cleavage to liberate the intracellular fragments that enter the nucleus to control gene transcription...
April 3, 2018: Cell Communication and Signaling: CCS
https://www.readbyqxmd.com/read/29558958/a-highlight-on-sonic-hedgehog-pathway
#12
REVIEW
Gabriela Basile Carballo, Jéssica Ribeiro Honorato, Giselle Pinto Farias de Lopes, Tania Cristina Leite de Sampaio E Spohr
Hedgehog (Hh) signaling pathway plays an essential role during vertebrate embryonic development and tumorigenesis. It is already known that Sonic hedgehog (Shh) pathway is important for the evolution of radio and chemo-resistance of several types of tumors. Most of the brain tumors are resistant to chemotherapeutic drugs, consequently, they have a poor prognosis. So, a better knowledge of the Shh pathway opens an opportunity for targeted therapies against brain tumors considering a multi-factorial molecular overview...
March 20, 2018: Cell Communication and Signaling: CCS
https://www.readbyqxmd.com/read/29534718/ras-enhances-tgf-%C3%AE-signaling-by-decreasing-cellular-protein-levels-of-its-type-ii-receptor-negative-regulator-spsb1
#13
Sheng Liu, Josephine Iaria, Richard J Simpson, Hong-Jian Zhu
BACKGROUND: Transformation by oncogene Ras overcomes TGF-β mediated growth inhibition in epithelial cells. However, it cooperates with each other to mediate epithelial to mesenchymal transition (EMT). The mechanism of how these two pathways interact with each other is controversial. METHODS: Molecular techniques were used to engineer expression plasmids for Ras, SPRY, TGF-β receptors, type I and II and ubiquitin. Immunoprecipitation and western blots were employed to determine protein-protein interactions, preotein levels, protein phosphorylation while immunofluorecesent staining for molecular co-localization...
March 13, 2018: Cell Communication and Signaling: CCS
https://www.readbyqxmd.com/read/29530069/inhibition-of-creb-binding-protein-beta-catenin-signaling-down-regulates-cd133-expression-and-activates-pp2a-pten-signaling-in-tumor-initiating-liver-cancer-cells
#14
Yuanyuan Tang, Joshua Berlind, Nirmala Mavila
BACKGROUND: The WNT-beta-catenin pathway is known to regulate cellular homeostasis during development and tissue regeneration. Activation of WNT signaling increases the stability of cytoplasmic beta-catenin and enhances its nuclear translocation. Nuclear beta-catenin function is regulated by transcriptional co-factors such as CREB binding protein (CBP) and p300. Hyper-activated WNT-beta-catenin signaling is associated with many cancers. However, its role in inducing stemness to liver cancer cells, its autoregulation and how it regulates tumor suppressor pathways are not well understood...
March 12, 2018: Cell Communication and Signaling: CCS
https://www.readbyqxmd.com/read/29463261/hmgb2-is-associated-with-malignancy-and-regulates-warburg-effect-by-targeting-ldhb-and-fbp1-in-breast-cancer
#15
Deyuan Fu, Jing Li, Jinli Wei, Zhengquan Zhang, Yulin Luo, Haosheng Tan, Chuanli Ren
BACKGROUND: High-mobility group box 2 (HMGB2) is implicated in tumorigenesis in various cancers. However, the clinical significance of HMGB2 signaling in human breast cancer progression remains unknown. METHODS: We investigated HMGB2 expression in 185 cases of primary breast cancer and matched normal breast tissue specimens, and explored the underlying mechanisms of altered HMGB2 expression as well as the impact of this altered expression on breast cancer growth and on aerobic glycolysis using in vitro and animal models of breast cancer...
February 20, 2018: Cell Communication and Signaling: CCS
https://www.readbyqxmd.com/read/29458395/herbal-formula-huang-qin-ge-gen-tang-enhances-5-fluorouracil-antitumor-activity-through-modulation-of-the-e2f1-ts-pathway
#16
Haizhou Liu, Hui Liu, Zhiyi Zhou, Robert A Parise, Edward Chu, John C Schmitz
BACKGROUND: 5-Fluorouracil (5-FU) remains the most widely used agent to treat colorectal cancer (CRC). However, its clinical efficacy is currently limited by the development of drug resistance. Traditional Chinese Herbal Medicine (TCM) has been shown to enhance the efficacy of standard anticancer agents. However, there are only a limited number of well-controlled preclinical and clinical studies documenting the potential benefit of TCM. Herein, we screened a series of TCM formulas in in vitro and in vivo animal models to identify biologically active formulas that were effective against CRC...
February 20, 2018: Cell Communication and Signaling: CCS
https://www.readbyqxmd.com/read/29402287/oxidative-phosphorylation-activation-is-an-important-characteristic-of-dox-resistance-in-hepatocellular-carcinoma-cells
#17
Li Wu, Jiayu Zhao, Kexin Cao, Xiao Liu, Hao Cai, Jiaqi Wang, Weidong Li, Zhipeng Chen
BACKGROUND: Despite the implications for tumor growth and cancer drug resistance, the mechanisms underlying differences in energy metabolism among cells remain unclear. METHODS: To analyze differences between cell types, cell viability, ATP and α-ketoglutaric acid levels, the oxygen consumption rate and extracellular acidification rate, and the expression of key enzymes involved in α-KG metabolism and transfer were examined. Additionally, UPLC-MS/MS was used to determine the doxorubicin (DOX) content in SMMC-7721 and SMMC-7721/DOX cells...
February 5, 2018: Cell Communication and Signaling: CCS
https://www.readbyqxmd.com/read/29391067/lncrna-hotair-promotes-cell-migration-and-invasion-by-regulating-mkl1-via-inhibition-mir206-expression-in-hela-cells
#18
Peng Zheng, Ze Yin, Ying Wu, Yao Xu, Ying Luo, Tong-Cun Zhang
BACKGROUND: Long non-coding RNAs (lncRNAs) have emerged as a new and crucial layer of gene regulation in recent years and regulate various biological processes such as carcinogenesis and metastasis. LncRNA HOTAIR, an oncogenic lncRNA, is involved in human tumorigenesis and dysregulated in cervical cancer. Megakaryoblastic leukemia 1 (MKL1), as a transcription coactivity factor, involved in cancer metastasis and cell differentiation. However, the precise mechanism of biological roles of HOTAIR and MKL1 in cancer cells remain unclear...
February 1, 2018: Cell Communication and Signaling: CCS
https://www.readbyqxmd.com/read/29321062/notch-signaling-triggered-via-the-ligand-dll4-impedes-m2-macrophage-differentiation-and-promotes-their-apoptosis
#19
Sylvain Pagie, Nathalie Gérard, Béatrice Charreau
BACKGROUND: Notch signaling controls many cellular processes, including cell fate determination, cell differentiation, proliferation and apoptosis. In mammals, four Notch receptors (Notch 1-4) can interact with five distinct ligands [Jagged1, Jagged2, Delta-like 1 (DLL1), DLL3, and DLL4]. We previously reported that Notch activation is modulated in endothelial cells and monocytes during inflammation and showed that inflammation upregulates DLL4 on endothelial cells. DLL4 promotes differentiation of blood monocytes into proinflammatory M1 macrophages...
January 10, 2018: Cell Communication and Signaling: CCS
https://www.readbyqxmd.com/read/29329585/involvement-of-hedgehog-pathway-in-early-onset-aggressive-molecular-subtypes-and-metastatic-potential-of-breast-cancer
#20
Syeda Kiran Riaz, Jahangir Sarwar Khan, Syed Tahir Abbas Shah, Fen Wang, Lin Ye, Wen G Jiang, Muhammad Faraz Arshad Malik
BACKGROUND: Dysregulation of hedgehog pathway is observed in numerous cancers. Relevance of hedgehog pathway genes in cancer cohort and inhibition of its downstream effector (GLI1) towards metastasis in cell lines are explored in the study. METHOD: One hundred fifty fresh tumours of breast cancer patients were collected for the study. Based on differential expression, panel of 6 key regulators of the pathway (SHH, DHH, IHH, PTCH1, SMO and GLI1) in microarray datasets were identified...
January 8, 2018: Cell Communication and Signaling: CCS
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