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Genetics and Molecular Research: GMR

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https://www.readbyqxmd.com/read/28301675/review-article-bioinformatics-an-overview-and-its-applications
#1
W J S Diniz, F Canduri
Technological advancements in recent years have promoted a marked progress in understanding the genetic basis of phenotypes. In line with these advances, genomics has changed the paradigm of biological questions in full genome-wide scale (genome-wide), revealing an explosion of data and opening up many possibilities. On the other hand, the vast amount of information that has been generated points the challenges that must be overcome for storage (Moore's law) and processing of biological information. In this context, bioinformatics and computational biology have sought to overcome such challenges...
March 15, 2017: Genetics and Molecular Research: GMR
https://www.readbyqxmd.com/read/28301674/single-cell-transcriptome-profiling-revealed-differences-in-gene-expression-during-oocyte-maturation-in-haimen-white-goats
#2
X Y Yin, G H Cheng, H Y Guo, Q Wang, Y J Li, H Zhang
Juvenile in vitro embryo transfer is an important animal reproductive technology that can shorten the generation interval of livestock, explore the reproductive potential of dams with excellent genetic traits, accelerate genetic progress and production efficiency of the herd, and provide a wealth of genetic resources for livestock breeding. However, oocytes from kids do not develop as well as those from female goats during in vitro maturation. To identify differences during different stages of oocyte maturation, we used single cell transcriptome sequencing to compare gene expression in mature oocytes from kids and female goats...
March 15, 2017: Genetics and Molecular Research: GMR
https://www.readbyqxmd.com/read/28301673/comparison-between-different-selection-indices-in-energy-cane-breeding
#3
A A C de Azeredo, L L Bhering, B P Brasileiro, C D Cruz, L C I Silveira, R A Oliveira, J C Bespalhok Filho, E Daros
Sugarcane breeding programs have been adapting to a new market demand: aside from high sucrose yield per hectare, the sector needs new cultivars with higher fiber percentages. The selection of sugarcane clones based on phenotype alone is a complex task. The selected clones should display high performance in a series of yield- and quality-related traits. Selection indices can provide information about which clones can best combine the traits of agronomic interest. In this study, different selection indices were evaluated in a population of 220 clones...
March 15, 2017: Genetics and Molecular Research: GMR
https://www.readbyqxmd.com/read/28301672/red-sindhi-cattle-in-brazil-population-structure-and-distribution
#4
J C C Panetto, M V G B Silva, R M H Leite, M A Machado, F A T Bruneli, D R L Reis, M G C D Peixoto, R S Verneque
The Red Sindhi cattle breed was imported to Brazil in small numbers. Nowadays, the herds of this breed are distributed in the Northeast, Southeast and Midwest regions of the country. In this study, DNA samples of animals originating from 15 herds in the Northeast and Southeast regions have been analyzed to obtain the ancestry proportions, and to gain a better understanding of the current population structure of this breed in Brazil. Samples were genotyped using three different single nucleotide polymorphism (SNP) marker panels...
March 15, 2017: Genetics and Molecular Research: GMR
https://www.readbyqxmd.com/read/28301671/a-clinical-study-of-bone-mesenchymal-stem-cells-for-the-treatment-of-hepatic-fibrosis-induced-by-hepatolenticular-degeneration
#5
D Zhang
The efficacy of bone marrow mesenchymal stem cell (BMSC) on liver fibrosis in animal has been proven, but a few studies have been made in human body and few such researches in China. This study was designed to investigate the effect of BMSC treatment on hepatic fibrosis induced by hepatolenticular degeneration and the influence on serological indicators. Sixty patients with liver fibrosis induced by hepatolenticular degeneration were randomly divided into two groups, a penicillamine group and a BMSCs plus penicillamine group, with 30 patients in each...
March 15, 2017: Genetics and Molecular Research: GMR
https://www.readbyqxmd.com/read/28301670/mns-duffy-and-kell-blood-groups-among-the-uygur-population-of-xinjiang-china
#6
G Y Lin, X L Du, J J Shan, Y N Zhang, Y Q Zhang, Q H Wang
Human blood groups are a significant resource for patients, leading to a fierce international competition in the screening of rare blood groups. Some rare blood group screening programs have been implemented in western countries and Japan, but not particularly in China. Recently, the genetic background of ABO and Rh blood groups for different ethnic groups or regions in China has been focused on increasingly. However, rare blood groups such as MN, Duffy, Kidd, MNS, and Diego are largely unexplored. No systematic reports exist concerning the polymorphisms and allele frequencies of rare blood groups in China's ethnic minorities such as Uygur and Kazak populations of Xinjiang, unlike those on the Han population...
March 15, 2017: Genetics and Molecular Research: GMR
https://www.readbyqxmd.com/read/28301669/population-genetic-analysis-and-conservation-strategies-for-redtail-shrimp-fenneropenaeus-penicillatus-using-ten-microsatellite-markers
#7
Y Y Cao, J B Shangguan, Z B Li
Fenneropenaeus penicillatus, which is on the Red List of Endangered Species for China, is an important shrimp species. However, there is not enough genetic information on F. penicillatus for conservation and management purposes. Ten microsatellite markers were used to analyze the genetic diversity, genetic differentiation, and population structure of F. penicillatus to provide scientific information for the conservation of the species. Low genetic diversity and moderate genetic differentiation were found among 12 putative populations [Beihai, Dongshan (DS), Hainan (HN), Lianjiang, Nanao (NA), Ningde (ND), Putian, Quanzhou (QZ), Xiamen (XM), Shenzhen, Zhanjiang, and Zhangpu] along the southeast coast of China...
March 15, 2017: Genetics and Molecular Research: GMR
https://www.readbyqxmd.com/read/28301668/lack-of-association-between-card10-carma3-tag-snps-and-psoriasis-vulgaris-in-the-southern-chinese-population
#8
G Shi, M F Zhang, P Y Liao, T T Wang, S J Li, Y M Fan, K J Zhu
Previously, we determined that the CARD11 rs4722404 single nucleotide polymorphism (SNP) increases risk of early-onset psoriasis vulgaris (PsV). Moreover, the CARD14 gene polymorphism c.C2458T (p.Arg820Trp) is associated with clinical features of this disease. CARMA1/CARD11, CARMA2/CARD14, and CARMA3/CARD10 are conserved across many species and constitute a family of proteins, all of the members of which contain various functional domains characteristic of this group. The NF-κB signaling pathway, regulated by the CARMA family of scaffold proteins and its eponymous component, is a crucial mediator in the pathogenesis of psoriasis...
March 15, 2017: Genetics and Molecular Research: GMR
https://www.readbyqxmd.com/read/28301667/molecular-cloning-sequencing-and-expression-of-eimeria-tenella-hsp70-partial-gene
#9
A L G Bogado, G F Martins, J P Sasse, J da S Guimarães, J L Garcia
Members of the Eimeria genus are protozoan parasites of the subphylum Apicomplexa (Eimeriidae family), and belong to the coccidia group. Eimeria tenella is one of the most pathogenic species owing to its ability to penetrate the mucosa, and cause inflammation and damage. It is an obligate intracellular parasite that causes disease by destroying the host cells during multiplication. Heat shock protein 70 (HSP70) is a molecular chaperone that prevents cellular stress. The objective of this study was to clone, sequence, and express E...
March 15, 2017: Genetics and Molecular Research: GMR
https://www.readbyqxmd.com/read/28290620/changes-on-microsatellites-of-expressed-sequence-tag-of-sugarcane-saccharum-spp-during-vegetative-propagation
#10
R Augusto, R C Maranho, C A Mangolin, J C Bespalhok Filho, M F P S Machado
The reduction in sugarcane productivity in subsequent cutting stages may be related to a gradual decrease of the allele number and mean observed heterozygosity (HO) in the sugarcane ratoon. This hypothesis was tested assessing the number of alleles and HO values in 10 expressed sequence tag microsatellites (Est-SSR loci) of the sugarcane varieties RB72454 and RB867515 in different cutting stages. Changes of allele numbers in samples of different cutting stages were observed in seven and six EstSSR loci of the RB72454 and RB867515 varieties, respectively...
March 8, 2017: Genetics and Molecular Research: GMR
https://www.readbyqxmd.com/read/28290619/microbial-diversity-in-raw-milk-and-traditional-fermented-dairy-products-hurood-cheese-and-jueke-from-inner-mongolia-china
#11
M L Gao, H M Hou, X X Teng, Y L Zhu, H S Hao, G L Zhang
Hurood cheese (HC) and Jueke (Jk) are 2 traditional fermented dairy products produced from raw milk (RM) in the Inner Mongolia region of China. They have a long history of production and consumption. The microbial compositions of RM, HC, and Jk vary greatly, and are influenced by their geographical origins and unique processing methods. In this study, 2 batches of RM, HC, and Jk samples were collected (April and August 2015) from the Zhenglan Banner, a region located in the southern part of Inner Mongolian belonging to the Xilingol league prefecture...
March 8, 2017: Genetics and Molecular Research: GMR
https://www.readbyqxmd.com/read/28290618/c3435t-polymorphism-of-the-mdr1-gene-is-not-associated-with-blood-levels-of-hypothalamus-pituitary-adrenal-axis-hormones-in-healthy-male-subjects
#12
A Suzuki, Y Matsumoto, T Shirata, K Goto, M Enokido, K Otani
In vitro studies have shown that multidrug resistance protein 1 (MDR1) has an affinity for cortisol; however, in vivo association studies on the relationship between MDR1 gene polymorphisms and blood cortisol levels have produced inconsistent results. Therefore, we examined the effects of the C3435T polymorphism of the MDR1 gene on blood levels of hypothalamus-pituitary-adrenal (HPA) axis hormones such as cortisol and adrenocorticotropic hormone (ACTH) in healthy subjects. The subjects comprised 30 healthy Japanese males...
March 8, 2017: Genetics and Molecular Research: GMR
https://www.readbyqxmd.com/read/28290617/digital-expression-analysis-of-the-genes-associated-with-salinity-resistance-after-overexpression-of-a-stress-responsive-small-gtp-binding-rabg-protein-in-peanut
#13
J M Sui, G Li, G X Chen, M Y Yu, S T Ding, J S Wang, L X Qiao
The Rab protein family is the largest family of the small GTP-binding proteins. Among them, the RabG genes are known to be responsive to abiotic stresses, but the molecular mechanisms of the stress responses mediated by RabG genes in plants is poorly understood. To investigate the molecular mechanism of AhRabG gene in peanut, transgenic plants overexpressing the AhRabG gene (S6) with relatively higher salinity resistance than the non-transgenic plants (S7) were obtained. Digital gene expression (DGE) sequencing was performed with the leaves of S6 and S7 plants before and after salinity-stress treatment...
March 8, 2017: Genetics and Molecular Research: GMR
https://www.readbyqxmd.com/read/28290616/expression-of-the-stem-cell-factor-in-fibroblasts-endothelial-cells-and-macrophages-in-periapical-tissues-in-human-chronic-periapical-diseases
#14
S Q Shen, R Wang, S G Huang
Stem cell factor (SCF), an important stem cell cytokine, has multiple functions. Fibroblasts (FBs), mature mast cells, endothelial cells (ECs), and eosinophil granulocytes can produce SCF in the inflammatory process. Therefore, we aimed to observe SCF expression in FBs, ECs, and macrophages (MPs) in periapical tissues in human chronic periapical disease and investigate the effects of cells expressing SCF in pathogenesis of the disease. Healthy (N = 20), periapical cyst (N = 15), and periapical granuloma (N = 15) tissues were fixed in 10% formalin for 48 h, embedded in paraffin, and stained with hematoxylin and eosin to observe histological changes...
March 8, 2017: Genetics and Molecular Research: GMR
https://www.readbyqxmd.com/read/28290615/mir-214-regulates-oral-cancer-kb-cell-apoptosis-through-targeting-rassf5
#15
T K Li, K Yin, Z Chen, Y Bao, S X Zhang
Ras association domain family member 5 (RASSF5), a member of the Ras association domain family, induces cell apoptosis by phosphorylating FOXO3a, which triggers target gene BIM (pro-apoptotic factor) activation. MiR-214 is overexpressed in oral cancer tissue, indicating its possible involvement in oral cancer pathogenesis. Bioinformatics analysis has revealed a complimentary sequence between miR-214 and the 3'-UTR of RASSF5 mRNA. However, whether miR-124 regulates RASSF5 in oral cancer remains poorly understood...
March 8, 2017: Genetics and Molecular Research: GMR
https://www.readbyqxmd.com/read/28290614/establishment-and-application-of-molecular-id-in-the-main-inbred-lines-of-chinese-cabbage
#16
X X Zhang, X B Tang, Y Liu, Y W Zhang
Chinese cabbage is an important cruciferous vegetable in China. The differences in the morphology and other characteristics of the different varieties of Chinese cabbage are generally caused by their different genes. Using the simple sequence repeat (SSR) DNA molecular markers is an effective way to identify different genotypes. The identification of a genetic relationship is a key point in the breeding process, and it plays an important role in guiding parent selection and breeding of high-yield varieties...
March 8, 2017: Genetics and Molecular Research: GMR
https://www.readbyqxmd.com/read/28290613/selection-of-experimental-strawberry-fragaria-x-ananassa-hybrids-based-on-selection-indices
#17
S D Vieira, D C de Souza, I A Martins, G H M R Ribeiro, L V Resende, A K L Ferraz, A G Galvão, J T V de Resende
The strawberry (Fragaria x ananassa Dutch.), is the only vegetable belonging to the rosacea family. All strawberry species have now emerged from wild species and belong to the genus Fragaria, being that this genus presents more than 45 described species, and only 11 are considered natural species. Due to the octoploid nature of strawberry and its variability after hybridization, selecting one or more characters may result in unfavorable genotypes and even the exclusion of promising ones, because negative genetic correlations have been observed among them that cause inefficient selection...
March 8, 2017: Genetics and Molecular Research: GMR
https://www.readbyqxmd.com/read/28290612/immunohistochemical-localization-of-sex-hormone-receptors-in-two-raillietina-tapeworms
#18
L Chen, Y M Sun, L Mu, Y Zeng, H Y Li, T H Yang
Sex hormone receptors play critical roles in development and reproduction. However, it is not known whether they exist in Raillietina tapeworms, and if they do, whether they have a similar function to that in vertebrates. We examined the immunohistochemical distributions of androgen receptors (ARs), estrogen receptors (ERs), and progesterone receptors (PRs) in the tissues of two tapeworm species: Raillietina echinobothrida and Raillietina tetragona. Immunopositive ARs were found in the entire reproductive system of R...
March 8, 2017: Genetics and Molecular Research: GMR
https://www.readbyqxmd.com/read/28290611/effect-of-increased-uv-b-radiation-on-carotenoid-accumulation-and-total-antioxidant-capacity-in-tobacco-nicotiana-tabacum-l-leaves
#19
J Shen, C Q Jiang, Y F Yan, B R Liu, C L Zu
Carotenoids are important components of plant antioxidant systems, which protect photosystems from photooxidative destruction during ultraviolet-B (UV-B) exposure. The influence of carotenoids on total antioxidant capacity (TAC) of plants has rarely been studied. In this study, tobacco (Nicotiana tabacum L., 'K326') seedlings exposed to UV-B radiation were used in order to evaluate the effects of ambient levels of UV-B radiation on carotenoid accumulation. The aim was to investigate whether carotenoids could enhance TAC as a means of UV protection...
March 8, 2017: Genetics and Molecular Research: GMR
https://www.readbyqxmd.com/read/28252174/molecular-marker-based-genetic-diversity-analysis-of-scantly-studied-brazilian-accessions-of-a-medicinal-plant-morinda-citrifolia-l-noni
#20
P N Bordallo, A M R Monteiro, J A Sousa, F A S Aragão
Morinda citrifolia L., commonly known as noni, has been used for the treatment of various diseases for over two centuries. It was introduced and widely disseminated in Brazil because of its high market value and ease of adaptation to the soil and climatic conditions of the country. The aim of this study was to estimate the genetic variability of noni accessions from the collection of Embrapa Agroindústria Tropical in Brazil. We evaluated 36 plants of the 13 accessions of noni from the germplasm collection of M...
February 23, 2017: Genetics and Molecular Research: GMR
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