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Genetics and Molecular Research: GMR

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https://www.readbyqxmd.com/read/28692127/diversity-and-genetic-structure-of-the-native-brazil-nut-tree-bertholletia-excelsa-bonpl-population
#1
J C Cabral, A B Baldoni, H Tonini, V C R Azevedo, L D Giustina, A V Tiago, A A B Rossi
The present study was carried out in a native Brazil nut tree population (Bertholletia excelsa Bonpl., Lecythidaceae) to assess its genetic diversity and structure. Ten microsatellite markers were used to genotype 198 adult trees (B. excelsa). The population presented high genetic diversity and inbreeding absence rates. The empirical Bayesian method showed three distinct groups in the structure of this population. Molecular analysis of variance showed 98% variability within groups, and 2% between groups. The genetic divergence (FST) indicated little difference between groups; thus, suggesting efficient gene flow between the analyzed B...
July 6, 2017: Genetics and Molecular Research: GMR
https://www.readbyqxmd.com/read/28692126/environmental-stratifications-for-soybean-cultivar-recommendation-and-its-consistency-over-time
#2
R M Pacheco, J B Duarte, R G Branquinho, P I D M Souza
Stratification of environments is a strategy to capitalize genotype x environment (GxE) interaction, which can optimize the process of assessment and cultivar recommendation, increasing productivity in a target environmental population. The objective of this study was to assess environmental stratification methods based on the analysis of GxE interaction, to identify consistent agronomic zones across time for soybean. Grain yield data of inbred lines from three maturity groups (early, medium, and late) were used...
July 6, 2017: Genetics and Molecular Research: GMR
https://www.readbyqxmd.com/read/28692125/steroid-metabolism-gene-polymorphisms-and-their-implications-on-breast-and-ovarian-cancer-prognosis
#3
E V W Dos Santos, L N R Alves, I D Louro
A role for estrogen in the etiology of breast and ovarian cancers has been suggested; therefore, genetic polymorphisms in steroid metabolism genes could be involved in the carcinogenesis of these tumors. We have aimed to investigate the role of GSTP1 and CYP17 polymorphisms and their correlation with MSI (microsatellite instability) and LOH (loss of heterozygosity) in AR, ERβ and CYP19 genes in women from Espírito Santo State, Brazil. The study population consisted of 107 female breast and 24 ovarian tumors...
July 6, 2017: Genetics and Molecular Research: GMR
https://www.readbyqxmd.com/read/28692124/genetic-variability-of-a-brazilian-capsicum-frutescens-germplasm-collection-using-morphological-characteristics-and-ssr-markers
#4
S I C Carvalho, L B Bianchetti, C F Ragassi, C S C Ribeiro, F J B Reifschneider, G S C Buso, F G Faleiro
Characterization studies provide essential information for the conservation and use of germplasm in plant breeding programs. In this study, 103 Capsicum frutescens L. accessions from the Active Germplasm Bank of Embrapa Hortaliças, representative of all five Brazilian geographic regions, were characterized based on morphological characteristics and microsatellite (or simple sequence repeat - SSR) molecular markers. Morphological characterization was carried out using 57 descriptors, and molecular characterization was based on 239 alleles from 24 microsatellite loci...
July 6, 2017: Genetics and Molecular Research: GMR
https://www.readbyqxmd.com/read/28692123/mitochondrial-dna-control-region-analysis-of-three-ethnic-populations-in-lower-northern-part-of-thailand
#5
U Suyasunanont, M Nakkuntod, S Mirasena
The lower northern part of Thailand contains various genetically diverse ethnic populations. The sequences of the mitochondrial DNA hypervariable region were studied in three ethnic populations inhabiting Phitsanulok Province. One hundred and nine nucleotide sequences - 53, 29, and 27 from Hmongs (Hill tribe), Lao Songs, and Thai-Siams, respectively - were collected. The haplotypes were generated from 1130 nucleotides of the entire control region. Eighty-six haplotypes were found in the three ethnic populations, and no shared haplotypes were found between populations...
July 6, 2017: Genetics and Molecular Research: GMR
https://www.readbyqxmd.com/read/28692122/alteration-of-656-g-t-and-607-c-a-polymorphisms-in-interleukin-18-il-18-gene-in-house-dust-mite-sensitive-allergic-rhinitis-patients-in-thailand
#6
A Tungtrongchitr, J Jumpasri, N Sookrung, N Visitsunthorn, P Tantilipikorn, O Piboonpocanan, N Indrawattana, R Tungtrongchitr, W Chaicumpa
Allergic rhinitis (AR) is an IgE-mediated inflammation of the nasal membranes, which is naturally triggered by aeroallergens. House dust mites (HDM) are the most common inhalant allergens. Interleukin-18 (IL-18) has been established as an essential cytokine that can activate the generation of IgE. This randomized controlled study aimed to identify the possible relationship of the genetic variations in the IL-18 gene with AR in mite-sensitive Thai patients. Study subjects consisted of 150 AR patients and 50 normal participants...
July 6, 2017: Genetics and Molecular Research: GMR
https://www.readbyqxmd.com/read/28692121/molecular-analysis-of-the-gstt1-gene-polymorphism-in-patients-with-clinical-manifestation-of-atherosclerosis
#7
J V M Martins, D A Rodrigues, K S F Silva, I R Costa, M H Lagares, F L Campedelli, A M Barbosa, M P Morais, K K V O Moura
Atherosclerosis is a chronic inflammatory disease formed by the accumulation of lipids in the innermost layer and large-caliber artery (tunica intima). This accumulation, along with platelet factors, stimulates the proliferation of muscle cells in this region. Over than 400 genes may be related to the pathology since they regulate endothelial function, coagulation, inflammation, metabolism of amino acids, lipids, and carbohydrates. Glutathione S-transferases (GST) are enzymes that catalyze the polymorphic detoxification of metabolites produced by oxidative stress within the cells, which is induced by reactive oxygen species...
July 6, 2017: Genetics and Molecular Research: GMR
https://www.readbyqxmd.com/read/28692120/bayesian-analyses-of-genetic-parameters-for-growth-traits-in-nellore-cattle-raised-on-pasture
#8
F B Lopes, J L Ferreira, R B Lobo, G J M Rosa
This study was carried out to investigate (co)variance components and genetic parameters for growth traits in beef cattle using a multi-trait model by Bayesian methods. Genetic and residual (co)variances and parameters were estimated for weights at standard ages of 120 (W120), 210 (W210), 365 (W365), and 450 days (W450), and for pre- and post-weaning daily weight gain (preWWG and postWWG) in Nellore cattle. Data were collected over 16 years (1993-2009), and all animals were raised on pasture in eight farms in the North of Brazil that participate in the National Association of Breeders and Researchers...
July 6, 2017: Genetics and Molecular Research: GMR
https://www.readbyqxmd.com/read/28692119/improvement-in-orthopedic-outcome-score-and-reduction-in-il-1%C3%AE-cxcl13-and-tnf-%C3%AE-in-synovial-fluid-of-osteoarthritis-patients-following-arthroscopic-knee-surgery
#9
Z M Li, M Li
Knee osteoarthritis (KOA) is a common degenerative joint disease and immune system dysregulation has been implicated in its pathogenesis. The effect of arthroscopic knee surgery, an important method for KOA diagnosis and treatment, on the expression of immune regulators remains poorly understood. We aimed to investigate the clinical efficacy of such surgery and its impact on IL-1β, CXCL13, and TNF-α expression in the knee joint synovial fluid of osteoarthritis patients. Fifty-seven patients having undergone arthroscopic knee surgery in our hospital were included...
July 6, 2017: Genetics and Molecular Research: GMR
https://www.readbyqxmd.com/read/28692118/selection-of-maize-inbred-lines-and-gene-expression-for-resistance-to-ear-rot
#10
G S Pereira, R G V Pinho, E V R V Pinho, L P M Pires, L A Y Bernardo Junior, J L A Pereira, M P Melo
In recent years, there has been a large incidence of fungi causing "ear rot" in maize in Brazil, the main fungus being Fusarium verticillioides. The most efficient and competitive alternative for control of this disease consists of using maize hybrids resistant to this pathogen. Thus, the aims of this study were to analyze the genetic variability of maize inbred lines in regard to resistance to ear rot to observe if there is a maternal effect to resistance to ear rot, to study genetic control of the traits evaluated in hybrids originating from inbred lines of the maize breeding program at the Agriculture Department of Universidade Federal de Lavras (Lavras, MG, Brazil), and characterize the gene expression pattern related to the plant defense mechanism against F...
July 6, 2017: Genetics and Molecular Research: GMR
https://www.readbyqxmd.com/read/28692117/clinical-significance-and-expression-of-puma-mcl-1-and-p53-in-human-renal-cell-carcinoma-and-para-carcinoma-tissues
#11
H B Xia, H W Cui, L Su, Z H Zhang, X Y Yang, S Q Ning, X L Su
We investigated the expression level of p53 upregulated modulator of apoptosis (PUMA), myeloid cell leukemia-I (MCL-1), and p53 in renal cell carcinoma (RCC) and para-carcinoma tissues, as well as their clinical significance. The expression levels of PUMA, MCL-1, and p53 in RCC and para-carcinoma tissues were measured using immunohistochemical and quantitative real-time PCR methods. Correlations between protein expression and pathological characteristics were analyzed. Renal clear cell carcinoma showed elevated MCL-1 and p53 protein expression (P > 0...
July 6, 2017: Genetics and Molecular Research: GMR
https://www.readbyqxmd.com/read/28692116/variability-among-capsicum-baccatum-accessions-from-goi%C3%A3-s-brazil-assessed-by-morphological-traits-and-molecular-markers
#12
A L A Martinez, J S P Araújo, C F Ragassi, G S C Buso, F J B Reifschneider
Capsicum peppers are native to the Americas, with Brazil being a significant diversity center. Capsicum baccatum accessions at Instituto Federal (IF) Goiano represent a portion of the species genetic resources from central Brazil. We aimed to characterize a C. baccatum working collection comprising 27 accessions and 3 commercial cultivars using morphological traits and molecular markers to describe its genetic and morphological variability and verify the occurrence of duplicates. This set included 1 C. baccatum var...
July 6, 2017: Genetics and Molecular Research: GMR
https://www.readbyqxmd.com/read/28692115/an-optimized-protocol-for-dna-extraction-in-plants-with-a-high-content-of-secondary-metabolites-based-on-leaves-of-mimosa-tenuiflora-willd-poir-leguminosae
#13
S R Arruda, D G Pereira, M M Silva-Castro, M G Brito, A M Waldschmidt
Some species are characterized by a high content of tannins, alkaloids, and phenols in their leaves. These secondary metabolites are released during DNA extraction and might hinder molecular studies based on PCR (polymerase chain reaction). To provide an efficient method to extract DNA, Mimosa tenuiflora, an important leguminous plant from Brazilian semiarid region used in popular medicine and as a source of fuelwood or forage, was used. Eight procedures previously reported for plants were tested and adapted from leaf tissues of M...
July 6, 2017: Genetics and Molecular Research: GMR
https://www.readbyqxmd.com/read/28692114/association-of-endothelin-1-gene-polymorphisms-with-essential-hypertension-in-a-chinese-population
#14
Z Fang, M Li, Z Ma, G Tu
Endothelin-1 (ET-1) is the most potent endogenous vasoconstrictor and is involved in several vascular disorders such as hypertension. Its strong interaction with other vasoactive hormone systems suggests that the ET-1 gene (EDN1) is a potential candidate molecule that influences the risk of developing hypertension. Recently, two single nucleotide polymorphisms in EDN1 have been reported to be associated with hypertension: Lys198Asn and 3A/4A (-134delA) located in the 5'-untranslated region. To determine the association of these two polymorphisms with hypertension, we genotyped patients and controls (N = 537) and compared the allele and genotype frequencies between groups...
July 6, 2017: Genetics and Molecular Research: GMR
https://www.readbyqxmd.com/read/28671260/phenotypic-and-genotypic-characterization-of-staphylococcus-aureus-isolates-in-milk-from-flocks-diagnosed-with-subclinical-mastitis
#15
A R E O Xavier, A C Almeida, C N Souza, L M V Silva, A X A Ruas, D A Sanglard, A F M Júnior, A M E Oliveira, M A S Xavier
The Staphylococcus aureus is the most common isolated microorganism in ruminant animal species diagnostic with clinical or subclinical mastitis. Dairy herds with these diseases can transfer S. aureus into the milk supply, which can lead to food poisoning in humans. The objective of this study was to evaluate the profile of antimicrobial susceptibility, the presence of femA gene, the genetic relationships among isolates of S. aureus obtained from milk originating from flocks diagnosed with subclinical mastitis in nine rural properties in the northern of Minas Gerais State...
June 29, 2017: Genetics and Molecular Research: GMR
https://www.readbyqxmd.com/read/28671259/transferability-of-microsatellite-markers-in-syagrus-coronata-mart-becc-arecaceae-an-iconic-palm-tree-from-the-brazilian-semiarid-region
#16
R R Simplicio, D G Pereira, A M Waldschmidt
The licuri palm Syagrus coronata plays a key role in the ecology and economy of Brazilian semiarid region. Nonetheless, genetic data about populations of this species are absent even though the intensive and uncontrolled exploitation since colonial periods has threatened the sustainability and viability of licuri populations. Therefore, we attempted to test the efficacy of transferability of microsatellite loci isolated from three palm tree species to S. coronata to analyze the population of this species throughout their range...
June 29, 2017: Genetics and Molecular Research: GMR
https://www.readbyqxmd.com/read/28671258/selection-of-candidate-reference-genes-and-validation-for-real-time-pcr-studies-in-rice-plants-exposed-to-low-temperatures
#17
P A Auler, L C Benitez, M N do Amaral, I L Vighi, G S Rodrigues, L C da Maia, E J B Braga
Rice is a cereal that presents a great ability to adapt to different soil and climate conditions. However, as it is a tropical crop with C3 metabolism, it performs better in warm temperatures with high solar radiation. Tolerance to stress caused by low temperatures is a highly complex process that involves various metabolic pathways and cellular compartments, resulting in general or specific effects on plant growth and development. In order to observe the true effect of a particular stress on genetic expression, reference genes need to be chosen for real-time PCRs, the expression levels of which should remain stable independent of the situation imposed...
June 29, 2017: Genetics and Molecular Research: GMR
https://www.readbyqxmd.com/read/28671257/haplotypes-and-polymorphism-in-the-ccr5-gene-in-sickle-cell-disease
#18
A F Nascimento, J S Oliveira, J C Silva Junior, A A L Barbosa
Sickle cell disease shows several clinical manifestations in distinct levels of severity. This heterogeneity is due to the haplotype variability associated with the HbS gene, levels of fetal hemoglobin and environmental conditions, which modify the disease expression. Science community believes that the presence of a polymorphism in the CCR5 gene, which is related to chronic inflammatory state, could confer a higher survival rate and a lower number of inflammatory events to these patients since the deletion in CCR5Δ32 would knock out the CCR5 gene...
June 29, 2017: Genetics and Molecular Research: GMR
https://www.readbyqxmd.com/read/28671256/genome-wide-analysis-of-salinity-stress-induced-dna-methylation-alterations-in-cotton-gossypium-hirsutum-l-using-the-me-dip-sequencing-technology
#19
X K Lu, N Shu, J J Wang, X G Chen, D L Wang, S Wang, W L Fan, X N Guo, L X Guo, W W Ye
Cytosine DNA methylation is a significant form of DNA modification closely associated with gene expression in eukaryotes, fungi, animals, and plants. Although the reference genomes of cotton (Gossypium hirsutum L.) have been publically available, the salinity-stress-induced DNA methylome alterations in cotton are not well understood. Here, we constructed a map of genome-wide DNA methylation characteristics of cotton leaves under salt stress using the methylated DNA immunoprecipitation sequencing method. The results showed that the methylation reads on chromosome 9 were most comparable with those on the other chromosomes, but the greatest changes occurred on chromosome 8 under salt stress...
June 29, 2017: Genetics and Molecular Research: GMR
https://www.readbyqxmd.com/read/28671255/maize-hybrid-stability-in-environments-under-water-restriction-using-mixed-models-and-factor-analysis
#20
A O Santos, J J Nuvunga, C P Silva, L P M Pires, R G Von Pinho, L J M Guimarães, M Balestre
In several crops, the water deficit is perhaps the main limiting factor in the search for high yields. The objective of this study was to evaluate the phenotypic stability of maize hybrids in environments with and without water restriction using the analytical factor (AF) approach. We evaluated 171 maize hybrids in 14 environments, divided into environments with (A1, A2, A3, A4, A5, A6, and A7) and without (A8, A9, A10, A11, A12, A13, and A14) water restriction, over a period of 7 years. Each year, 36 hybrids were evaluated...
June 29, 2017: Genetics and Molecular Research: GMR
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