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Cancer Science

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https://www.readbyqxmd.com/read/27906498/st3gal6-mediates-the-effect-of-mir-26a-on-cell-growth-migration-and-invasion-in-hepatocellular-carcinoma-via-the-akt-mtor-pathway
#1
Mingming Sun, Xuzi Zhao, Leilei Liang, Xufeng Pan, Hao Lv, Yongfu Zhao
Aberrant sialylation profiles on the cell surface have been recognized for their potential diagnostic value in identifying the regulation of tumor properties in several cancers, including hepatocellular carcinoma (HCC). Recently, increasing evidence has suggested that the deregulation of microRNA (miRNA) is a common feature in human cancers. In this study, we found obvious up-regulation of ST3GAL6 both in HCC cell lines and in tissue samples. The altered expression of ST3GAL6 was found to correlate with cell proliferation, migration and invasion ability in HCC...
December 1, 2016: Cancer Science
https://www.readbyqxmd.com/read/27889946/combined-fibrinogen-and-neutrophil-lymphocyte-ratio-as-a-prognostic-marker-of-advanced-esophageal-squamous-cell-carcinoma
#2
Takashi Kijima, Takaaki Arigami, Yasuto Uchikado, Yoshikazu Uenosono, Yoshiaki Kita, Tetsuhiro Owaki, Shinichiro Mori, Hiroshi Kurahara, Yuko Kijima, Hiroshi Okumura, Kousei Maemura, Sumiya Ishigami, Shoji Natsugoe
Patients with advanced esophageal squamous cell carcinoma (ESCC) is received chemoradiotherapy or chemotherapy for clinical management. However, it is difficult to predict tumor response and prognosis using blood markers before starting treatments. The purpose of this study was to investigate the pre-treatment plasma fibrinogen and neutrophil-lymphocyte ratio (NLR) in patients with advanced ESCC treated with chemoradiotherapy or chemotherapy, and to assess the clinical utility of a combined score using these blood markers, named as the F-NLR (fibrinogen and NLR) score, as a predictor of tumor response and prognosis...
November 27, 2016: Cancer Science
https://www.readbyqxmd.com/read/27889936/abnormal-heavy-light-chain-ratio-after-treatment-is-associated-with-shorter-survival-in-patients-with-iga-myeloma
#3
Yasuhito Suehara, Hiroyuki Takamatsu, Kota Fukumoto, Manabu Fujisawa, Kentaro Narita, Yoshiaki Usui, Masami Takeuchi, Kelly Endean, Kosei Matsue
Immunoglobulin (Ig) heavy/light chain (HLC) assays enable the separate quantification of the different light chain types of each Ig class. We retrospectively analyzed the correlation of heavy/light chain ratio (HLCR) with clinical status and its impact on outcome in 120 patients with multiple myeloma (MM). Abnormal HLCR was seen more frequently in patients with poorer myeloma response, and it appeared to be more sensitive for detecting clonality in IgA myeloma compared to IgG myeloma after treatment. Among the 85 patients who achieved ≥VGPR, the patients remained HLCR abnormal were showed significantly shorter overall survival (OS) compared to those achieving a normal HLCR (not reached vs...
November 27, 2016: Cancer Science
https://www.readbyqxmd.com/read/27889930/receptor-tyrosine-kinase-amplification-is-predictive-of-distant-metastasis-in-patients-with-oral-squamous-cell-carcinoma
#4
Yu Oikawa, Kei-Ichi Morita, Kou Kayamori, Kousuke Tanimoto, Kei Sakamoto, Hiroto Katoh, Shumpei Ishikawa, Johji Inazawa, Hiroyuki Harada
This study aimed to clarify the genomic factors associated with the diagnosis and prognosis of oral squamous cell carcinoma via next-generation sequencing. We evaluated data from 220 cases of oral squamous cell carcinoma. Genomic DNA was eluted using formalin-fixed, paraffin-embedded samples, and targeted resequencing of 50 cancer-related genes was performed. In total, 311 somatic mutations were detected in 220 patients, consisting of 68 synonymous mutations and 243 non-synonymous mutations. Genes carrying mutations included TP53, CDKN2A, and PIK3CA in 79 (35...
November 27, 2016: Cancer Science
https://www.readbyqxmd.com/read/27885740/asp5878-a-selective-fgfr-inhibitor-to-treat-fgfr3-dependent-urothelial-cancer-with-or-without-chemoresistance
#5
Aya Kikuchi, Tomoyuki Suzuki, Taisuke Nakazawa, Masateru Iizuka, Ayako Nakayama, Tohru Ozawa, Minoru Kameda, Nobuaki Shindoh, Tadashi Terasaka, Masaaki Hirano, Sadao Kuromitsu
FGF/FGFR gene aberrations such as amplification, mutation and fusion are associated with many types of human cancers including urothelial cancer. FGFR kinase inhibitors are expected to be a targeted therapy for urothelial cancer harboring FGFR3 gene alternations. ASP5878, a selective inhibitor of FGFR1, 2, 3 and 4 under clinical investigation, selectively inhibited cell proliferation of urothelial cancer cell lines harboring FGFR3 point mutation or fusion (UM-UC-14, RT-112, RT4 and SW 780) among 23 urothelial cancer cell lines...
November 25, 2016: Cancer Science
https://www.readbyqxmd.com/read/27870265/antizyme-inhibitor-1-a-potential-carcinogenic-molecule
#6
REVIEW
Shiqiao Qiu, Jing Liu, Feiyue Xing
Polyamines are multivalent and organic cations essential for cellular growth, proliferation, differentiation and apoptosis. Increased levels of polyamines are closely associated with numerous forms of cancer. An autoregulatory circuit composed by the ornithine decarboxylase(ODC), antizymes(AZ) and antizyme inhibitor (AZI) governs the intracellular level of polyamines. AZ binds with ODC to inhibit the ODC activity and to promote the ubiquitin-independent degradation of ODC. AZI binds to AZ with a higher affinity than ODC...
November 21, 2016: Cancer Science
https://www.readbyqxmd.com/read/27870147/management-strategies-in-lynch-syndrome-and-familial-adenomatous-polyposis-a-national-healthcare-survey-in-japan
#7
Tomoki Yamano, Michiko Hamanaka, Akihito Babaya, Kei Kimura, Masayoshi Kobayashi, Miki Fukumoto, Kiyoshi Tsukamoto, Masafumi Noda, Nagahide Matsubara, Naohiro Tomita, Kenichi Sugihara
Lynch syndrome (LS) and familial adenomatous polyposis (FAP) are major sources of hereditary colorectal cancer (CRC) and associated with other malignancies. There is some heterogeneity in management strategies in Japan. We performed a survey of management of hereditary CRC in hospitals that are members of the Japan Society of Colorectal Cancer Research (JSCCR). One hundred and ninety departments responded, of which 127 were from designated cancer care hospitals (DCCHs) according to the Japanese government. There were 25 488 operations for CRC in these departments in 2015...
November 21, 2016: Cancer Science
https://www.readbyqxmd.com/read/27865045/high-krt8-expression-promotes-tumor-progression-and-metastasis-of-gastric-cancer
#8
Fang Jian, Wang Hao, Liu Yun, Ding Fangfang, Ni Ying, Shao Shihe
Keratin8 (KRT8) is the major component of the intermediate filament cytoskeleton and predominantly expressed in simple epithelial tissues. Aberrant expression of KRT8 is associated with multiple tumor progression and metastasis. However, the role of KRT8 in Gastric Cancer (GC) remains unclear. In this study, KRT8 expression was investigated and it was found to be up-regulated along with human GC progression and metastasis at both mRNA and protein levels in human gastric cancer tissues. In addition, KRT8 over expression enhanced the proliferation and migration of human gastric cancer cells, whereas the knock-down of KRT8 by siRNA only inhibited migration of human gastric cancer cells...
November 17, 2016: Cancer Science
https://www.readbyqxmd.com/read/27859949/the-clinicopathological-significance-of-spc18-in-colorectal-cancer-spc18-participates-in-tumor-progression
#9
Takuya Hattori, Kazuhiro Sentani, Naohide Oue, Naoya Sakamoto, Wataru Yasui
Colorectal cancer (CRC) is one of the leading causes of cancer-related death worldwide. In order to identify novel prognostic markers or therapeutic targets for CRC, we searched for candidate genes in our comprehensive gene expression libraries, and focused on SEC11A, which encodes the SPC18 protein. SPC18 plays a key role in the endoplasmic reticulum-Golgi secretory pathway and presumably regulates the secretion of various secretory proteins. An immunohistochemical analysis of SPC18 in 137 CRC tissue samples demonstrated that 79 (58%) CRC cases were positive for SPC18...
November 17, 2016: Cancer Science
https://www.readbyqxmd.com/read/27862697/zfp36l2-promotes-cancer-cell-aggressiveness-and-is-regulated-by-antitumor-microrna-375-in-pancreatic-ductal-adenocarcinoma
#10
Keiichi Yonemori, Naohiko Seki, Hiroshi Kurahara, Yusaku Osako, Tetsuya Idichi, Takayuki Arai, Keiichi Koshizuka, Yoshiaki Kita, Kosei Maemura, Shoji Natsugoe
Due to its aggressive nature, pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal and hard-to-treat malignancies. Recently developed targeted molecular strategies have contributed to remarkable improvements in the treatment of several cancers. However, such therapies have not been applied to PDAC. Therefore, new treatment options are needed for PDAC based on current genomic approaches. Expression of microRNA-375 (miR-375) was significantly reduced in miRNA expression signatures of several types of cancers, including PDAC...
November 14, 2016: Cancer Science
https://www.readbyqxmd.com/read/27862769/ns5abp37-inhibits-liver-cancer-by-impeding-lipogenesis-and-cholesterogenesis
#11
Shenghu Feng, Ming Han, Li Zhou, Qi Wang, Zhongshu Li, Yaru Li, Hongping Lu, Ting Liu, Yanhua Ma, Shunai Liu, Jun Cheng
The molecular mechanism underlying nonalcoholic fatty liver disease (NAFLD) progression to hepatocellular carcinoma (HCC) remains unknown. In this study, immunohistochemistry staining result showed that NS5ABP37 protein, which is in a state of lower expression in tumor tissues, decreased as with increasing degree of HCC malignancy. Two cell models, HepG2 and L02, are used to analyze the mechanism between NS5ABP37 and HCC. In agreement, NS5ABP37 protein overexpression significantly suppressed cell proliferation, caused G1/S cell cycle arrest, and induced apoptosis by increasing caspase-3/7 activity and cleaved caspase-3 levels...
November 11, 2016: Cancer Science
https://www.readbyqxmd.com/read/27862679/foxp3-regulates-arhgap15-expression-and-affects-migration-of-glioma-cells-via-the-rac1-signaling-pathway
#12
Zhen Sun, Biao Zhang, Chen Wang, Tao Fu, Lianling Li, Qiaoli Wu, Ying Cai, Jinhuan Wang
FOXP3 plays a crucial role in the development and function of regulatory T cells and was recently identified as a tumor suppressor in different cancer types. FOXP3 is expressed in normal brain tissues, but is strongly downregulated or absent in glioblastomas. In order to understand the FOXP3 adjustment mechanisms in glioma cell, We do a set of DNA microarray in U87 overexpressing FOXP3 and test by Quantitative real-time PCR,Western blot analysis and immunohistochemistry in vitro and vivo. So we focus on ARHGAP15...
November 11, 2016: Cancer Science
https://www.readbyqxmd.com/read/27862655/mourning-dr-alfred-g-knudson-the-two-hit-hypothesis-tumor-suppressor-genes-and-the-tuberous-sclerosis-complex
#13
REVIEW
Okio Hino, Toshiyuki Kobayashi
On July 10, 2016, Alfred G. Knudson, Jr., MD, PhD, a leader in cancer research, died at the age of 93 years. We deeply mourn his loss. Knudson's two-hit hypothesis, published in 1971, has been fundamental for understanding tumor suppressor genes and familial tumor-predisposing syndromes. To understand the molecular mechanism of two-hit-initiated tumorigenesis, Knudson utilized an animal model of a dominantly inherited tumor, the Eker rat. From the molecular identification of Tsc2 germline mutations, the Eker rat became a model for tuberous sclerosis complex (TSC), a familial tumor-predisposing syndrome...
November 11, 2016: Cancer Science
https://www.readbyqxmd.com/read/27801993/predictive-factors-of-tumor-immune-microenvironment-for-long-term-follow-up-in-early-stage-breast-cancer
#14
Mina Okabe, Uhi Toh, Nobutaka Iwakuma, Shuko Saku, Momoko Akashi, Yuko Kimitsuki, Naoko Seki, Akihiko Kawahara, Etsuyo Ogo, Kyogo Itoh, Yoshito Akagi
To investigate the correlation of immunologic factors in the tumor environment of breast cancer, using immunohistological staining to evaluate the expression of PD-1/PD-L1, PTEN, TILs and macrophages, and to analyze the association between the immunologic factors and clinical outcome for patients with early stage breast cancer (EBC). A total of ninety-seven EBC patients who underwent standard surgery were investigated. PD-1/PD-L1, PTEN expression and the density of CD3+ TILs, CD8+ TILs, and CD163+ macrophages were evaluated by immunohistochemical analysis...
November 1, 2016: Cancer Science
https://www.readbyqxmd.com/read/27801961/heterogeneous-impact-of-drinking-according-to-treatment-method-on-survival-in-head-and-neck-cancer-a-prospective-study
#15
Michi Sawabe, Hidemi Ito, Isao Oze, Satoyo Hosono, Daisuke Kawakita, Hideo Tanaka, Yasuhisa Hasegawa, Shingo Murakami, Keitaro Matsuo
Alcohol consumption is an established risk factor, and also a potential prognostic factor, for squamous cell carcinoma of the head and neck (HNSCC). However, little is known about whether the prognostic impact of alcohol consumption differs by treatment modality. Here, we evaluated the association between alcohol drinking and survival by treatment method to the primary site in 427 patients with HNSCC treated between 2005-2013 at Aichi Cancer Center Central Hospital. The impact of alcohol on prognosis was measured by multivariable Cox regression adjusted for established prognostic factors...
November 1, 2016: Cancer Science
https://www.readbyqxmd.com/read/27783867/vascular-endothelial-growth-factor-promoter-based-conditionally-replicative-adenoviruses-effectively-suppress-growth-of-malignant-pleural-mesothelioma
#16
Akiko Harada, Junji Uchino, Taishi Harada, Noriaki Nakagaki, Junko Hisasue, Masaki Fujita, Koichi Takayama
Malignant mesothelioma (MM) incidence is increasing drastically worldwide as an occupational disease resulting from asbestos exposure. However, no curative treatment for MM of advanced stage is available. Thus, new therapeutic approaches for MM are required. Because malignant pleural mesothelioma (MPM) cells spread along the pleural surface in most patients, MPM can be targeted using intrapleural therapeutic approaches. In this study, we investigated the effectiveness of the intrapleural instillation of a replication-competent adenovirus as an oncolytic agent against MPM...
October 26, 2016: Cancer Science
https://www.readbyqxmd.com/read/27783866/areg-triggered-egfr-activation-confers-in-vivo-crizotinib-resistance-of-eml4-alk-lung-cancer-and-circumvention-by-egfr-inhibitors
#17
Hirokazu Taniguchi, Shinji Takeuchi, Koji Fukuda, Takayuki Nakagawa, Sachiko Arai, Shigeki Nanjo, Tadaaki Yamada, Hiroyuki Yamaguchi, Hiroshi Mukae, Seiji Yano
Crizotinib, a first-generation anaplastic lymphoma kinase (ALK) tyrosine-kinase inhibitor, is known to be effective against echinoderm microtubule-associated protein-like 4 (EML4)-ALK-positive non-small cell lung cancers. Nonetheless, the tumors subsequently become resistant to crizotinib and recur in almost every case. The mechanism of the acquired resistance needs to be deciphered. In this study, we established crizotinib-resistant cells (A925LPE3-CR) via long-term administration of crizotinib to a mouse model of pleural carcinomatous effusions; this model involved implantation of the A925LPE3 cell line, which harbors the EML4-ALK gene rearrangement...
October 26, 2016: Cancer Science
https://www.readbyqxmd.com/read/27783849/a-phase-%C3%AE-i-clinical-trial-of-peptide-cocktail-therapy-for-patients-with-advanced-pancreatic-cancer-venus-pc-study
#18
Nobuaki Suzuki, Shoichi Hazama, Haruo Iguchi, Kazuhiro Uesugi, Hiroaki Tanaka, Kosei Hirakawa, Atsushi Aruga, Takashi Hatori, Hidenobu Ishizaki, Yuzo Umeda, Toshiyoshi Fujiwara, Tetsuya Ikemoto, Mitsuo Shimada, Kazuhiko Yoshimatsu, Ryoichi Shimizu, Hiroto Hayashi, Koichiro Sakata, Hiroko Takenouchi, Hiroto Matsui, Yoshitaro Shindo, Michihisa Iida, Yasunobu Koki, Hideki Arima, Hiroyuki Furukawa, Tomio Ueno, Shigefumi Yoshino, Yusuke Nakamura, Masaaki Oka, Hiroaki Nagano
We previously conducted a phase I clinical trial combining the HLA-A*2402-restricted KIF20A-derived peptide vaccine with gemcitabine for advanced pancreatic cancer (PC) and confirmed its safety and immunogenicity in cancer patients. In this study, we conducted a multicenter, single-armed, phase II trial using two antiangiogenic cancer vaccines targeting VEGFR1 and VEGFR2 in addition to the KIF20A peptide. We attempted to evaluate the clinical benefit of the cancer vaccination in combination with gemcitabine...
October 26, 2016: Cancer Science
https://www.readbyqxmd.com/read/27779808/functional-and-therapeutic-relevance-of-hepatocyte-growth-factor-c-met-signaling-in-synovial-sarcoma
#19
Yoshinori Imura, Takaaki Nakai, Shutaro Yamada, Hidetatsu Outani, Satoshi Takenaka, Kenichiro Hamada, Nobuhito Araki, Kazuyuki Itoh, Hideki Yoshikawa, Norifumi Naka
Synovial sarcoma (SS) is an aggressive soft-tissue sarcoma with a poor prognosis and thus novel therapeutic strategies for SS are urgently required. In the present study, we investigated functional and therapeutic relevance of hepatocyte growth factor (HGF)/c-MET signaling in SS. Both HGF and c-MET were highly expressed in Yamato-SS cells, resulting in activation of c-MET and its downstream AKT and extracellular signal-regulated kinase signaling pathways, whereas c-MET was expressed but not activated in SYO-1 or HS-SY-II cells...
October 24, 2016: Cancer Science
https://www.readbyqxmd.com/read/27762090/wnt5b-associated-exosomes-promote-cancer-cell-migration-and-proliferation
#20
Takeshi Harada, Hideki Yamamoto, Shosei Kishida, Michiko Kishida, Chihiro Awada, Toshifumi Takao, Akira Kikuchi
Wnt5b, a member of the same family of proteins as Wnt5a of which overexpression is associated with cancer aggressiveness, is suggested to be involved in cancer progression, however details remain unclarified. We analyzed biochemical properties of purified Wnt5b and the mode of secretion of Wnt5b by cancer cells. Wnt5b was glycosylated at three asparagine residues and lipidated at one serine residue, and these post-translational modifications of Wnt5b are essential for secretion. Purified Wnt5b showed Dvl2 phosphorylation and Rac activation abilities to a similar extent as Wnt5a...
October 20, 2016: Cancer Science
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