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Clinical Advances in Hematology & Oncology: H&O

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https://www.readbyqxmd.com/read/29742084/first-line-use-of-novel-hormonal-agents-in-prostate-cancer-a-critical-appraisal
#1
Derek Raghavan
Castration has been the hallmark of the treatment of advanced prostate cancer for nearly a century. Conventional surgical or medical castration for the management of metastatic prostate cancer has been associated with an initial response rate greater than 60% to 70%, depending on the criteria employed. The median duration of the initial response is usually less than 3 to 5 years, however, depending on the extent of disease. The failure of disease to respond to castration has been associated with an increase in the production of adrenal androgens and/or the evolution of upregulated or mutated androgen receptors...
April 2018: Clinical Advances in Hematology & Oncology: H&O
https://www.readbyqxmd.com/read/29742083/update-on-signal-inhibitors-in-chronic-lymphocytic-leukemia
#2
Prajwal Boddu, Nitin Jain
The last decade has seen major progress in our understanding of the pathobiology of chronic lymphocytic leukemia (CLL) and the identification of potential new therapeutic targets. As a result, researchers have developed novel targeted therapies, several of which are already approved and many of which are in advanced stages of clinical development. These new agents are much less toxic than chemoimmunotherapy and may be preferred for their superior efficacy in patients with certain high-risk features, such as del(17p)...
April 2018: Clinical Advances in Hematology & Oncology: H&O
https://www.readbyqxmd.com/read/29742081/looking-ahead-to-new-therapies-in-small-cell-lung-cancer
#3
Charles M Rudin
No abstract text is available yet for this article.
April 2018: Clinical Advances in Hematology & Oncology: H&O
https://www.readbyqxmd.com/read/29742080/bayesian-approaches-to-evaluating-doses-of-drugs
#4
Gary L Rosner
No abstract text is available yet for this article.
April 2018: Clinical Advances in Hematology & Oncology: H&O
https://www.readbyqxmd.com/read/29742079/current-approaches-to-pregnancy-and-childbirth-in-women-with-von-willebrand-disease
#5
Jill M Johnsen
No abstract text is available yet for this article.
April 2018: Clinical Advances in Hematology & Oncology: H&O
https://www.readbyqxmd.com/read/29742078/enasidenib-for-patients-with-relapsed-acute-myeloid-leukemia-and-the-idh2-mutation
#6
Courtney DiNardo
No abstract text is available yet for this article.
April 2018: Clinical Advances in Hematology & Oncology: H&O
https://www.readbyqxmd.com/read/29742088/highlights-in-metastatic-colorectal-cancer-from-the-2018-american-society-of-clinical-oncology-gastrointestinal-cancers-symposium-commentary
#7
Axel Grothey
No abstract text is available yet for this article.
March 2018: Clinical Advances in Hematology & Oncology: H&O
https://www.readbyqxmd.com/read/29742087/highlights-in-metastatic-colorectal-cancer-from-the-2018-american-society-of-clinical-oncology-gastrointestinal-cancers-symposium
#8
(no author information available yet)
No abstract text is available yet for this article.
March 2018: Clinical Advances in Hematology & Oncology: H&O
https://www.readbyqxmd.com/read/29742086/highlights-in-pancreatic-cancer-from-the-2018-american-society-of-clinical-oncology-gastrointestinal-cancers-symposium-commentary
#9
Tanios Bekaii-Saab
No abstract text is available yet for this article.
March 2018: Clinical Advances in Hematology & Oncology: H&O
https://www.readbyqxmd.com/read/29742085/highlights-in-pancreatic-cancer-from-the-2018-american-society-of-clinical-oncology-gastrointestinal-cancers-symposium
#10
(no author information available yet)
No abstract text is available yet for this article.
March 2018: Clinical Advances in Hematology & Oncology: H&O
https://www.readbyqxmd.com/read/29742077/philadelphia-chromosome-positive-acute-lymphoblastic-leukemia-in-adults-current-treatments-and-future-perspectives
#11
Musa Yilmaz, Hagop Kantarjian, Farhad Ravandi-Kashani, Nicholas J Short, Elias Jabbour
Philadelphia chromosome-positive (Ph+) acute lymphoblastic leukemia (ALL) accounts for approximately one-fourth of cases of adult ALL. It typically presents with an aggressive clinical course, responds poorly to standard chemotherapy, and carries a high risk for relapse. The landscape of Ph+ ALL therapy has changed favorably since the development of tyrosine kinase inhibitors (TKIs). With the successful incorporation of TKIs into chemotherapy regimens, remissions occur more frequently and patients live longer...
March 2018: Clinical Advances in Hematology & Oncology: H&O
https://www.readbyqxmd.com/read/29742076/update-on-hairy-cell-leukemia
#12
Robert J Kreitman, Evgeny Arons
Hairy cell leukemia (HCL) is a chronic B-cell malignancy with multiple treatment options, including several that are investigational. Patients present with pancytopenia and splenomegaly, owing to the infiltration of leukemic cells expressing CD22, CD25, CD20, CD103, tartrate-resistant acid phosphatase (TRAP), annexin A1 (ANXA1), and the BRAF V600E mutation. A variant lacking CD25, ANXA1, TRAP, and the BRAF V600E mutation, called HCLv, is more aggressive and is classified as a separate disease. A molecularly defined variant expressing unmutated immunoglobulin heavy variable 4-34 (IGHV4-34) is also aggressive, lacks the BRAF V600E mutation, and has a phenotype of HCL or HCLv...
March 2018: Clinical Advances in Hematology & Oncology: H&O
https://www.readbyqxmd.com/read/29742075/the-timing-of-molecular-imaging-in-prostate-cancer
#13
Michael J Morris
No abstract text is available yet for this article.
March 2018: Clinical Advances in Hematology & Oncology: H&O
https://www.readbyqxmd.com/read/29742074/emerging-options-for-combination-therapy-in-multiple-myeloma
#14
Adriana C Rossi
No abstract text is available yet for this article.
March 2018: Clinical Advances in Hematology & Oncology: H&O
https://www.readbyqxmd.com/read/29742073/are-direct-acting-oral-anticoagulants-ready-for-prime-time-use-in-cancer-related-thrombosis
#15
Michael B Streiff
No abstract text is available yet for this article.
March 2018: Clinical Advances in Hematology & Oncology: H&O
https://www.readbyqxmd.com/read/29742072/cost-effectiveness-in-the-surgical-care-of-renal-cell-carcinoma
#16
(no author information available yet)
No abstract text is available yet for this article.
March 2018: Clinical Advances in Hematology & Oncology: H&O
https://www.readbyqxmd.com/read/29742098/advances-in-aggressive-lymphoma-from-the-2017-american-society-of-hematology-annual-meeting-and-exposition-commentary
#17
Frederick L Locke, Faysal Haroun
No abstract text is available yet for this article.
February 2018: Clinical Advances in Hematology & Oncology: H&O
https://www.readbyqxmd.com/read/29742097/advances-in-aggressive-lymphoma-from-the-2017-american-society-of-hematology-annual-meeting-and-exposition
#18
(no author information available yet)
No abstract text is available yet for this article.
February 2018: Clinical Advances in Hematology & Oncology: H&O
https://www.readbyqxmd.com/read/29742096/highlights-in-lymphoma-from-the-2017-american-society-of-hematology-meeting-commentary
#19
Craig H Moskowitz
No abstract text is available yet for this article.
February 2018: Clinical Advances in Hematology & Oncology: H&O
https://www.readbyqxmd.com/read/29742095/highlights-in-lymphoma-from-the-2017-american-society-of-hematology-annual-meeting-and-exposition
#20
(no author information available yet)
No abstract text is available yet for this article.
February 2018: Clinical Advances in Hematology & Oncology: H&O
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