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Clinical Advances in Hematology & Oncology: H&O

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https://www.readbyqxmd.com/read/29040258/prognostic-and-therapeutic-implications-of-dna-repair-gene-mutations-in-advanced-prostate-cancer
#1
Michael T Schweizer, Emmanuel S Antonarakis
Recent work directed toward understanding the molecular features of advanced prostate cancers has revealed a relatively high incidence of both germline and somatic alterations in genes involved in DNA damage repair (DDR). Many of these alterations likely play a critical role in the pathogenesis of more aggressive prostate cancers-leading to genomic instability and an increased probability of the development of lethal disease. However, because the ability to repair DNA damage with a high degree of fidelity is critical to an individual cell's survival, tumor cells harboring alterations in DDR pathway genes are also more susceptible to drugs that induce DNA damage or impair alternative DNA repair pathways...
October 2017: Clinical Advances in Hematology & Oncology: H&O
https://www.readbyqxmd.com/read/29040257/current-challenges-in-the-management-of-essential-thrombocythemia
#2
Ariel Kleman, Arun K Singavi, Laura C Michaelis
Essential thrombocythemia (ET), an uncommon blood cancer, is one of the classic myeloproliferative neoplasms, a category that also includes polycythemia vera and primary myelofibrosis. All 3 diseases are clonal hematopoietic stem cell disorders. Since 2005, when scientists discovered a molecular aberration driving clonal hematopoiesis in polycythemia vera, our understanding of the genomic underpinnings of these conditions has increased rapidly. Over the last decades, primary prevention of thrombotic and hemorrhagic complications has improved the lives of patients with ET, and the ability to characterize the disease by the presence or absence of molecular mutations has lent precision to our prognostic models...
October 2017: Clinical Advances in Hematology & Oncology: H&O
https://www.readbyqxmd.com/read/29040256/the-role-of-genomics-in-patients-with-advanced-prostate-cancer
#3
Maha H Hussain
No abstract text is available yet for this article.
October 2017: Clinical Advances in Hematology & Oncology: H&O
https://www.readbyqxmd.com/read/29040255/how-i-treat-stage-iv-non-small-cell-lung-cancer-in-the-absence-of-any-actionable-oncogenic-driver
#4
Mark A Socinski
No abstract text is available yet for this article.
October 2017: Clinical Advances in Hematology & Oncology: H&O
https://www.readbyqxmd.com/read/29040254/when-to-initiate-treatment-in-smoldering-multiple-myeloma
#5
María-Victoria Mateos
No abstract text is available yet for this article.
October 2017: Clinical Advances in Hematology & Oncology: H&O
https://www.readbyqxmd.com/read/29040253/direct-to-consumer-advertising-of-cancer-treatments
#6
Lowell E Schnipper
No abstract text is available yet for this article.
October 2017: Clinical Advances in Hematology & Oncology: H&O
https://www.readbyqxmd.com/read/29040252/in-the-pipeline-encorafenib-and-binimetinib-in-braf-mutated-melanoma
#7
Keith Flaherty
No abstract text is available yet for this article.
October 2017: Clinical Advances in Hematology & Oncology: H&O
https://www.readbyqxmd.com/read/29040251/what-is-the-optimal-duration-of-adjuvant-therapy-in-colon-cancer
#8
Anthony F Shields
No abstract text is available yet for this article.
October 2017: Clinical Advances in Hematology & Oncology: H&O
https://www.readbyqxmd.com/read/29040249/letter-from-the-editor-how-to-treat-hodgkin-lymphoma
#9
Brad S Kahl
No abstract text is available yet for this article.
October 2017: Clinical Advances in Hematology & Oncology: H&O
https://www.readbyqxmd.com/read/29036042/highlights-in-lymphoma-from-the-2017-asco-meeting-and-the-14th-icml-commentary
#10
Craig H Moskowitz
No abstract text is available yet for this article.
September 2017: Clinical Advances in Hematology & Oncology: H&O
https://www.readbyqxmd.com/read/29036041/highlights-in-lymphoma-from-the-2017-american-society-of-clinical-oncology-annual-meeting-and-the-14th-international-conference-on-malignant-lymphoma
#11
(no author information available yet)
No abstract text is available yet for this article.
September 2017: Clinical Advances in Hematology & Oncology: H&O
https://www.readbyqxmd.com/read/28949942/testicular-seminoma-oncologic-rationale-and-role-of-surgery-in-treatment
#12
Nitin K Yerram, Hans C Arora, Abhinav Khanna, Kyle Ericson, Andrew Y Sun, Paurush Babbar, Naveen Nandanan, Andrew J Stephenson
Seminomas account for approximately 50% of all cases of testicular cancer. Testicular cancer is a highly curable disease that can be broadly classified as either seminomatous or nonseminomatous; the management and treatment of the 2 forms vary widely. Although surgery plays a large role in the management of nonseminoma, its role in the management of seminoma is much more limited. Most clinicians in the United States choose orchiectomy followed by surveillance for patients with stage I seminomatous disease, and chemotherapy or radiation-followed by surgery for the management of residual masses-for patients with disease that is stage II and higher...
September 2017: Clinical Advances in Hematology & Oncology: H&O
https://www.readbyqxmd.com/read/28949941/polycythemia-vera-from-new-modified-diagnostic-criteria-to-new-therapeutic-approaches
#13
Margherita Maffioli, Barbara Mora, Francesco Passamonti
Polycythemia vera (PV) is a Philadelphia chromosome-negative chronic myeloproliferative neoplasm that is associated with a Janus kinase 2 (JAK2) mutation in most cases. The most recent update to the World Health Organization diagnostic criteria for PV was published in 2016. These were the modifications with the greatest effect: (1) lowering the hemoglobin threshold, allowing a diagnosis of PV at 16.5 g/dL in males and at 16.0 g/dL in females and (2) introducing a hematocrit cutoff (49% in males and 48% in females)...
September 2017: Clinical Advances in Hematology & Oncology: H&O
https://www.readbyqxmd.com/read/28949940/optimal-use-of-radium-223-in-patients-with-metastatic-castration-resistant-prostate-cancer
#14
Daniel J George
No abstract text is available yet for this article.
September 2017: Clinical Advances in Hematology & Oncology: H&O
https://www.readbyqxmd.com/read/28949939/highlights-in-kidney-cancer-from-the-2017-american-society-of-clinical-oncology-annual-meeting
#15
(no author information available yet)
No abstract text is available yet for this article.
September 2017: Clinical Advances in Hematology & Oncology: H&O
https://www.readbyqxmd.com/read/28949938/the-value-in-cancer-care-consortium-addressing-financial-toxicity
#16
Allen S Lichter
No abstract text is available yet for this article.
September 2017: Clinical Advances in Hematology & Oncology: H&O
https://www.readbyqxmd.com/read/28949937/advances-in-the-management-of-primary-central-nervous-system-lymphoma
#17
Kieron Dunleavy
No abstract text is available yet for this article.
September 2017: Clinical Advances in Hematology & Oncology: H&O
https://www.readbyqxmd.com/read/28949936/optimal-treatment-for-platinum-sensitive-recurrent-ovarian-cancer
#18
Bradley J Monk
No abstract text is available yet for this article.
September 2017: Clinical Advances in Hematology & Oncology: H&O
https://www.readbyqxmd.com/read/28949935/letter-from-the-editor-book-club-the-panama-canal
#19
Brad S Kahl
No abstract text is available yet for this article.
September 2017: Clinical Advances in Hematology & Oncology: H&O
https://www.readbyqxmd.com/read/29036040/frontline-management-of-chronic-lymphocytic-leukemia
#20
Richard R Furman
No abstract text is available yet for this article.
August 2017: Clinical Advances in Hematology & Oncology: H&O
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