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Clinical Advances in Hematology & Oncology: H&O

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https://www.readbyqxmd.com/read/28212372/molecular-biology-of-gastroesophageal-cancers-opportunities-and-challenges
#1
REVIEW
Shaheer Khan, Sameh Mikhail, Joanne Xiu, Mohamed E Salem
Gastroesophageal (GE) malignancies make up a significant and growing segment of newly diagnosed cancers. Approximately 80% of patients who have GE cancers die within 5 years of diagnosis, which means that effective treatments for these malignancies need to be found. Currently, targeted therapies have a minimal role in this disease group. Intensive study of the molecular biology of GE cancers is a relatively new and ongoing venture, but it has already led to a significant increase in our understanding of these malignancies...
January 2017: Clinical Advances in Hematology & Oncology: H&O
https://www.readbyqxmd.com/read/28212371/circulating-tumor-cells-in-prostate-cancer-beyond-enumeration
#2
Jie-Fu Chen, Yi-Tsung Lu, Shirley Cheng, Hsian-Rong Tseng, Robert A Figlin, Edwin M Posadas
Circulating tumor cells (CTCs) are a population of rare cancer cells that have detached from the primary tumor and/or metastatic lesions and entered the peripheral circulation. Enumeration of CTCs has demonstrated value as a prognostic biomarker, and newer studies have pointed to information beyond enumeration that is of critical importance in prostate cancer. Technologic advances that permit examination of the morphology, function, and molecular content of CTCs have made it possible to measure these factors as part of liquid biopsy...
January 2017: Clinical Advances in Hematology & Oncology: H&O
https://www.readbyqxmd.com/read/28212370/the-evolution-of-allogeneic-stem-cell-transplant-for-children-and-adolescents-with-acute-myeloid-leukemia
#3
Allyson Flower, Mitchell S Cairo
Survival rates in subsets of pediatric patients who have acute myeloid leukemia (AML) with favorable risk features are now greater than 90%. However, outcomes for patients with high-risk (HR) features remain unacceptably poor. As novel technologies for the identification of HR biomarkers and the detection of residual disease are developed, risk stratification and the application of allogeneic hematopoietic stem cell transplant (HSCT) are evolving. HSCT has been shown to benefit subpopulations of pediatric patients with AML, including those with HR cytogenetic translocations, genetic mutations, and/or residual disease after induction...
January 2017: Clinical Advances in Hematology & Oncology: H&O
https://www.readbyqxmd.com/read/28212369/prognostic-biomarkers-in-early-stage-prostate-cancer
#4
Eric Klein
No abstract text is available yet for this article.
January 2017: Clinical Advances in Hematology & Oncology: H&O
https://www.readbyqxmd.com/read/28212368/aggressive-b-cell-lymphoma-the-double-hit-and-double-expressor-phenotypes
#5
Sonali M Smith
No abstract text is available yet for this article.
January 2017: Clinical Advances in Hematology & Oncology: H&O
https://www.readbyqxmd.com/read/28212367/superficial-vein-thrombosis-new-perspectives-and-observations-from-recent-clinical-trials
#6
Benilde Cosmi
No abstract text is available yet for this article.
January 2017: Clinical Advances in Hematology & Oncology: H&O
https://www.readbyqxmd.com/read/28212366/challenges-in-drug-development-for-children
#7
Peter C Adamson
No abstract text is available yet for this article.
January 2017: Clinical Advances in Hematology & Oncology: H&O
https://www.readbyqxmd.com/read/28212365/right-sided-vs-left-sided-colorectal-cancer
#8
Alan P Venook
No abstract text is available yet for this article.
January 2017: Clinical Advances in Hematology & Oncology: H&O
https://www.readbyqxmd.com/read/28212364/letter-from-the-editor-the-ash-rehash
#9
Brad S Kahl
No abstract text is available yet for this article.
January 2017: Clinical Advances in Hematology & Oncology: H&O
https://www.readbyqxmd.com/read/28212363/vegf-inhibitors-in-renal-cell-carcinoma
#10
REVIEW
Pankit Vachhani, Saby George
The arrival of targeted therapies-vascular endothelial growth factor (VEGF) pathway inhibitors and mammalian target of rapamycin (mTOR) inhibitors-and programmed death 1 (PD-1) inhibitors has transformed the management of renal cell carcinoma (RCC). Once considered fatal, with a median survival of approximately 1 year, these agents have nearly tripled overall survival and have raised hopes of a possible cure for advanced RCC. This review begins with a brief discussion of the seminal von Hippel-Lindau/hypoxia-inducible factor axis in RCC...
December 2016: Clinical Advances in Hematology & Oncology: H&O
https://www.readbyqxmd.com/read/28212362/the-management-of-psychological-issues-in-oncology
#11
REVIEW
Daniel C McFarland, Jimmie C Holland
Psychological issues in the cancer setting are highly prevalent and well documented, and can lead to adverse outcomes. Several series of guidelines have been put forth to ensure that both psychological and psychiatric issues are addressed. The management of psychological issues in cancer is relevant for clinicians whose patients are identified clinically or via screening mechanisms with psychological or psychiatric sequelae from cancer. This review describes the psychological impact of cancer, distress screening as a triage mechanism, and the presentation and management of several specific comorbid psychological/psychiatric diagnoses in the oncology setting...
December 2016: Clinical Advances in Hematology & Oncology: H&O
https://www.readbyqxmd.com/read/28212361/liver-transplant-and-hepatocellular-carcinoma
#12
Robert Wong
No abstract text is available yet for this article.
December 2016: Clinical Advances in Hematology & Oncology: H&O
https://www.readbyqxmd.com/read/28212360/is-there-a-role-for-single-agent-mek-inhibition-in-melanoma
#13
Douglas Johnson
No abstract text is available yet for this article.
December 2016: Clinical Advances in Hematology & Oncology: H&O
https://www.readbyqxmd.com/read/28212359/considerations-in-the-frontline-treatment-of-chronic-lymphocytic-leukemia
#14
Susan M O'Brien
No abstract text is available yet for this article.
December 2016: Clinical Advances in Hematology & Oncology: H&O
https://www.readbyqxmd.com/read/28212358/kidney-cancer-news
#15
(no author information available yet)
No abstract text is available yet for this article.
December 2016: Clinical Advances in Hematology & Oncology: H&O
https://www.readbyqxmd.com/read/28212357/is-precision-medicine-ready-for-use-in-breast-cancer
#16
Lajos Pusztai
No abstract text is available yet for this article.
December 2016: Clinical Advances in Hematology & Oncology: H&O
https://www.readbyqxmd.com/read/28212356/the-seamless-approach-to-drug-development-in-oncology
#17
Richard Pazdur
No abstract text is available yet for this article.
December 2016: Clinical Advances in Hematology & Oncology: H&O
https://www.readbyqxmd.com/read/28212355/letter-from-the-editor-the-end
#18
Bruce D Cheson
No abstract text is available yet for this article.
December 2016: Clinical Advances in Hematology & Oncology: H&O
https://www.readbyqxmd.com/read/27930619/novel-second-line-treatments-for-hepatocellular-carcinoma-discussion
#19
Catherine T Frenette, Riccardo Lencioni, Richard S Finn
No abstract text is available yet for this article.
December 2016: Clinical Advances in Hematology & Oncology: H&O
https://www.readbyqxmd.com/read/27930618/developing-a-treatment-plan-for-hepatocellular-carcinoma-the-continuum-of-care
#20
Richard S Finn
No abstract text is available yet for this article.
December 2016: Clinical Advances in Hematology & Oncology: H&O
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