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Gene Expression Patterns: GEP

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https://www.readbyqxmd.com/read/29793047/transcript-profiling-of-salt-tolerant-tobacco-mutants-generated-via-mutation-breeding
#1
Özge Çelik, Aybüke Ekşioğlu, Enes Yağız Akdaş
The main aim of the study is to identify the genes differentially, predominantly or specifically expressed in salt tolerant tobacco mutants, improved from Akhisar 97 and İzmir Özbaş varieties via mutation breeding, with respect to unstressed control plants. Seven tobacco mutants which have different salt tolerance capacities were evaluated by Gene Fishing analysis. Under stress conditions differentially expressed 100 reproducible bands were identified (74 of up-regulated and 20 of down-regulated while 6 were unknown)...
May 21, 2018: Gene Expression Patterns: GEP
https://www.readbyqxmd.com/read/29738878/identification-and-expression-of-carbonic-anhydrase-2-myosin-regulatory-light-chain-2-and-selenium-binding-protein-1-in-zebrafish-danio-rerio-implication-for-age-related-biomarkers
#2
Shuoqi Feng, Su Wang, Yashuo Wang, Qingyun Yang, Dejing Wang, Hongyan Li
Proteomic study has determined age-related changes in synthesis of carbonic anhydrase 2, myosin regulatory light chain 2 and selenium-binding protein 1 in muscle of post-menopausal women. However, little information is available regarding the expression and role of these proteins in early development and life span. In this study we showed that zebrafish ca2, myl2a, myl2b and selenbp1 were highly identical to their mammalian counterparts in primary and tertiary structures as well as genomic organization and syntenic map...
May 5, 2018: Gene Expression Patterns: GEP
https://www.readbyqxmd.com/read/29660410/the-spatial-and-developmental-expression-of-mouse-vwa8-von-willebrand-domain-containing-protein-8
#3
Brian S Grewe, Janet E Richmond, David E Featherstone
The Drosophila gene c12.2 was isolated in a screen examining mRNA binding proteins. Drosophila c12.2 is the mouse Vwa8 homolog. Various genome-wide associated studies have linked human Vwa8 to both neurological and oncological pathologies, which include autism, bipolar disorder, comorbid migraine, and acute myeloid leukemia, however, the function and role of the VWA8 protein remain poorly understood. To further analyze the Vwa8 gene in mouse, gene structure, protein homology modeling, and gene expression patterns were examined throughout mouse development...
April 13, 2018: Gene Expression Patterns: GEP
https://www.readbyqxmd.com/read/29649632/identification-of-runt-family-genes-involved-in-planarian-regeneration-and-tissue-homeostasis
#4
Zimei Dong, Yibo Yang, Guangwen Chen, Dezeng Liu
The runt family genes play important roles in physiological processes in eukaryotic organisms by regulation of protein transcription, such as hematopoietic system, proliferation of gastric epithelial cells and neural development. However, it remains unclear about the specific functions of these genes. In this study, the full-length cDNA sequences of two runt genes are first cloned from Dugesia japonica, and their roles are investigated by WISH and RNAi. The results show that: (1) the Djrunts are conserved during evolution; (2) the Djrunts mRNA are widely expressed in intact and regenerative worms, and their expression levels are up-regulated significantly on day 1 after amputation; (3) loss of Djrunts function lead to lysis or regeneration failure in the intact and regenerating worms...
April 9, 2018: Gene Expression Patterns: GEP
https://www.readbyqxmd.com/read/29635032/enriched-expression-of-the-ciliopathy-gene-ick-in-cell-proliferating-regions-of-adult-mice
#5
Ryotaro Tsutsumi, Taro Chaya, Takahisa Furukawa
Cilia are essential for sensory and motile functions across species. In humans, ciliary dysfunction causes "ciliopathies", which show severe developmental abnormalities in various tissues. Several missense mutations in intestinal cell kinase (ICK) gene lead to endocrine-cerebro-osteodysplasia syndrome or short rib-polydactyly syndrome, lethal recessive developmental ciliopathies. We and others previously reported that Ick-deficient mice exhibit neonatal lethality with developmental defects. Mechanistically, Ick regulates intraflagellar transport and cilia length at ciliary tips...
April 7, 2018: Gene Expression Patterns: GEP
https://www.readbyqxmd.com/read/29630949/the-expression-of-fgfr3-in-the-zebrafish-head
#6
Joanna K Ledwon, Sergey Y Turin, Arun K Gosain, Jolanta M Topczewska
Fibroblast growth factor (FGF) signaling is essential for many developmental processes and plays a pivotal role in skeletal homeostasis, regeneration and wound healing. FGF signals through one of five tyrosine kinase receptors: Fgfr1a, -1b, -2, -3, -4. To characterize the expression of zebrafish fgfr3 from the larval stage to adulthood, we used RNAscope in situ hybridization on paraffin sections of the zebrafish head. Our study revealed spatial and temporal distribution of fgfr3 transcript in chondrocytes of the head cartilages, osteoblasts involved in bone formation, ventricular zone of the brain, undifferentiated mesenchymal cells of the skin, and lens epithelium of the eye...
April 6, 2018: Gene Expression Patterns: GEP
https://www.readbyqxmd.com/read/29627454/expression-patterns-of-yes-associated-protein-1-in-the-developing-mouse-liver
#7
Wei Wei, Jeremy Lotto, Pamela A Hoodless
The Hippo signaling pathway regulates many cellular processes, but has been specifically associated with control organ size and tumor growth. Yes-associated protein 1 (YAP1) is a transcriptional cofactor, in the Hippo pathway, that regulates gene expression when localized in the nucleus. Elevated expression of YAP1 in adult mouse liver leads to hepatomegaly and can cause hepatocellular carcinoma; while the loss of function studies reveal its importance in regulating cholangiocyte development. Here, we report the expression of YAP1 in mouse embryonic and postnatal hepatic cells, using AFP-GFP transgenic mice to identify the hepatocyte lineage...
April 5, 2018: Gene Expression Patterns: GEP
https://www.readbyqxmd.com/read/29625185/epigenetic-modifications-in-the-embryonic-and-induced-pluripotent-stem-cells
#8
Rasoul Godini, Haider Yabr Lafta, Hossein Fallahi
Epigenetic modifications are involved in global reprogramming of the cell transcriptome. Therefore, synchronized major shifts in the expression of many genes could be achieved through epigenetic changes. The regulation of gene expression could be implemented by different epigenetic events including histone modifications, DNA methylation and chromatin remodelling. Interestingly, it has been documented that reprogramming of somatic cells to induced pluripotent stem (iPS) cells is also a typical example of epigenetic modifications...
April 4, 2018: Gene Expression Patterns: GEP
https://www.readbyqxmd.com/read/29571919/age-dependent-expression-pattern-in-the-mammalian-brain-of-a-novel-small-peptide-encoded-in-the-22q11-2-deletion-syndrome-region
#9
Sabrina Kragness, Mark A A Harrison, Joby J Westmoreland, Adam Burstain, Laurie R Earls
22q11.2 deletion syndrome (22q11.2DS) carries increased risk for both physical and psychiatric symptoms, including a high risk for schizophrenia. Understanding the genetic elements within the deletion region therefore has the potential to unlock the mysteries of both diseases. While most of the protein-coding genes in this region have been characterized, novel elements, such as non-coding RNAs and small Open Reading Frames (sORFs) remain unstudied. We have identified a novel, highly-conserved mouse sORF in a region of the mouse genome that is orthologous to a portion of the 22q11...
June 2018: Gene Expression Patterns: GEP
https://www.readbyqxmd.com/read/29548970/astacin-gene-family-of-metalloproteinases-in-planarians-structural-organization-and-tissue-distribution
#10
Maria Emilia Isolani, Renata Batistoni, Chiara Ippolito, Anna Maria Bianucci, Silvia Marracci, Leonardo Rossi
Planarian flatworms possess extraordinary regenerative capability and body plasticity, which rely on a composite population of stem cells, the neoblasts. Despite impressive advances have been recently achieved in the knowledge of neoblast biology, few is still known about factors that are released by differentiated tissues and influence the neoblast fate. Extracellular matrix (ECM) is a fundamental component of the stem cell niche and its remodeling affects stem cell fate. Here we provide the characterization of the astacin gene family of metalloproteinases in planarians, good candidate enzymes for generating dynamicity in the ECM...
June 2018: Gene Expression Patterns: GEP
https://www.readbyqxmd.com/read/29548969/tracheal-expression-of-osiris-gene-family-in-drosophila
#11
Aaron Scholl, Yuyang Yang, Patrick McBride, Kelly Irwin, Lan Jiang
The Drosophila trachea is a premier genetic system to investigate the fundamental mechanisms of tubular organ formation. Development of the trachea consists of the well understood early branch specification and migration processes, and the less clear later branch maturation process including the apical membrane expansion, cytoskeleton rearrangement, luminal matrix clearance, and air-filling. We identified seven members of the Osiris (Osi) gene family with obvious tracheal expression in Drosophila. In addition, HA-tagged Osi proteins are highly concentrated in vesicle-like structures at and near the apical membrane...
June 2018: Gene Expression Patterns: GEP
https://www.readbyqxmd.com/read/29510224/investigation-of-lamtor1-gene-and-protein-expressions-in-germinal-vesicle-and-metaphase-ii-oocytes-and-embryos-from-1-cell-to-blastocyst-stage-in-a-mouse-model
#12
Erkan Gumus, Ismail Sari, Meral Yilmaz, Ali Cetin
Improving the success of in vitro fertilization (IVF) and infertility treatment depend on understanding basic cellular and molecular mechanisms of human preimplantation development. Pre-implantation mouse embryo model is an ideal empiric system to understand these mechanisms. This study was aimed to investigate the gene and protein expressions of LAMTOR1 in mouse oocytes and pre-implantation embryos at different developmental stages. The findings demonstrate that LAMTOR1 was detected in the oocytes and in subsequent all stages of embryo development...
June 2018: Gene Expression Patterns: GEP
https://www.readbyqxmd.com/read/29486326/distribution-of-gonadotropin-inhibitory-hormone-gnih-in-male-luchuan-piglets
#13
Xiaoye Wang, Xun Li, Chuanhuo Hu
Gonadotropin inhibitory hormone (GnIH) has emerged as a novel hypothalamic neuropeptide that actively inhibits gonadotropin release in birds and mammals. Recent evidence indicates that GnIH not only acts as a key neurohormone that controls vertebrate reproduction but is also involved in stress response, food intake, and aggressive and sexual behaviors, suggesting a broad physiological role for this neuropeptide. To elucidate its multiple sites of action and potential functions, studying the detailed distribution of GnIH in different organs, except for the hypothalamus-pituitary-ovary/testis axis, is necessary...
June 2018: Gene Expression Patterns: GEP
https://www.readbyqxmd.com/read/29481878/molecular-characterization-tissue-distribution-localization-and-mrna-expression-of-the-bucky-ball-gene-in-the-dabry-s-sturgeon-acipenser-dabryanus-during-oogenesis
#14
Huan Ye, Huamei Yue, Xiaoge Yang, Chuangju Li, Qiwei Wei
In many organisms, germ cells are specified during embryogenesis by the inheritance of maternally deposited RNAs and proteins termed germ plasm. In vertebrates, the bucky ball (buc) gene plays an essential role in the germ plasm aggregation. In this study, the full-length cDNA of buc homologue in Dabry's sturgeon, Adbuc, was isolated and characterized. Multiple sequence alignments showed that the BUVE domain of Buc was highly conserved in vertebrates, despite exhibiting low identities with each other across the whole protein...
June 2018: Gene Expression Patterns: GEP
https://www.readbyqxmd.com/read/29462671/expression-of-the-adhesion-g-protein-coupled-receptor-a2-adgra2-during-xenopus-laevis-development
#15
Franziska A Seigfried, Petra Dietmann, Michael Kühl, Susanne J Kühl
The adhesion G protein-coupled receptor A2 (Adgra2) is a seven transmembrane receptor that has been described to be a regulator for angiogenesis in mice. Furthermore, the zebrafish ouchless mutant is unable to develop dorsal root ganglia through a disrupted trafficking of Adgra2. Besides RNA sequencing data, nothing is reported about Adgra2 in the south African crawled frog Xenopus laevis. In this study, we investigated for the first time the spatio-temporal expression of adgra2 during early Xenopus embryogenesis in detail...
June 2018: Gene Expression Patterns: GEP
https://www.readbyqxmd.com/read/29454044/the-expression-patterns-of-vestigial-like-family-member-4-genes-in-zebrafish-embryogenesis
#16
Chang Xue, Hai Hong Wang, Jun Zhu, Jun Zhou
Transcriptional cofactor Vestigial-like 4 (VGLL4) was considered to take part in the early stage of development. Different from human, three paralogs of vgll4 were found in zebrafish, which were vgll4a, vgll4b and vgll4l. However, the expression patterns of the three paralogs during zebrafish development remains unknown. In this study, we used in situ hybridization to elucidate the temporal and spatial expression of zebrafish vgll4 paralogs during normal embryonic and larval development. Similar expression was shown in certain areas at similar stages for the three paralogs...
June 2018: Gene Expression Patterns: GEP
https://www.readbyqxmd.com/read/29427758/screen-for-slit-robo-signaling-in-trunk-neural-cells-reveals-new-players
#17
Darwin Martinez, Nora Zuhdi, Michelle Reyes, Blanca Ortega, Dion Giovannone, Vivian M Lee, Maria Elena de Bellard
Slits ligands and their Robo receptors are involved in quite disparate cell signaling pathways that include axon guidance, cell proliferation, cell motility and angiogenesis. Neural crest cells emerge by delamination from neural cells in the dorsal neural tube, and give rise to various components of the peripheral nervous system in vertebrates. It is well established that these cells change from a non-migratory to a highly migratory state allowing them to reach distant regions before they differentiate. However, but the mechanism controlling this delamination and subsequent migration are still not fully understood...
June 2018: Gene Expression Patterns: GEP
https://www.readbyqxmd.com/read/29413438/early-development-of-the-enteric-nervous-system-visualized-by-using-a-new-transgenic-zebrafish-line-harboring-a-regulatory-region-for-choline-acetyltransferase-a-chata-gene
#18
Masataka Nikaido, Saki Izumi, Honoka Ohnuki, Yuki Takigawa, Kyo Yamasu, Kohei Hatta
The enteric nervous system (ENS) is the largest part of the peripheral nervous system in vertebrates. Toward the visualization of the development of the vertebrate ENS, we report our creation of a new transgenic line, Tg(chata:GGFF2) which has a 1.5-kb upstream region of the zebrafish choline acetyltransferase a (chata) gene followed by modified green fluorescent protein (gfp). During development, GFP + cells were detected in the gut by 60 h post-fertilization (hpf). In the gut of 6- and 12-days post-fertilization (dpf) larvae, an average of 92% of the GFP + cells were positive for the neuronal marker HuC/D, suggesting that GFP marks enteric neurons in this transgenic line...
June 2018: Gene Expression Patterns: GEP
https://www.readbyqxmd.com/read/29339137/oxygen-induced-alterations-in-the-expression-of-chromatin-modifying-enzymes-and-the-transcriptional-regulation-of-imprinted-genes
#19
William M Skiles, Avery Kester, Jane H Pryor, Mark E Westhusin, Michael C Golding, Charles R Long
Embryo culture and assisted reproductive technologies have been associated with a disproportionately high number of epigenetic abnormalities in the resulting offspring. However, the mechanisms by which these techniques influence the epigenome remain poorly defined. In this study, we evaluated the capacity of oxygen concentration to influence the transcriptional control of a selection of key enzymes regulating chromatin structure. In mouse embryonic stem cells, oxygen concentrations modulated the transcriptional regulation of the TET family of enzymes, as well as the de novo methyltransferase Dnmt3a...
June 2018: Gene Expression Patterns: GEP
https://www.readbyqxmd.com/read/29277544/cloning-and-gene-expression-analysis-of-two-cdna-of-cysteine-proteinase-genes-involved-in-programmed-cell-death-in-the-inner-integument-from-developing-seeds-of-jatropha-curcas-l
#20
Antônio José Rocha, Simone Pohl, Cristiane Sá Roriz Fonteles
In this paper, two cysteine proteinases were cloned from Jatropha curcas seeds. The full length cDNAs obtained from cloning of Jc-CysEP1 and Jc-CysEP2 genes were 1.516bp and 1500 pb, respectively. The Jc-CysEP1 contained a 1083bp open reading frame (ORF) coding for 360 amino acids. The JcCysEP1 protein sequence had an estimated native molecular weight of 36.89 kDa, with a predicted isoelectric point of 4.55. The average lengths of JcCysEP1 5' UTR and 3' UTR were 269 bp and 167bp, respectively. The Jc-CysEP2 contained a 1077 pb open reading frame (ORF) that encoded 358 amino acids...
January 2018: Gene Expression Patterns: GEP
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