Huiling Chen, Chenchen Liu, Meng Li, Yida Zhang, Zhendong Wang, Qiyao Jiang, Jianxin Wang, Qi Wang, Yue Zhuo
Diosbulbin B (DIOB) has been reported to cause serious liver injury. However, in traditional medicine, DIOB-containing herbs are highly safe in combination with ferulic acid (FA)-containing herbs, suggesting potential neutralizing effect of FA on the toxicity of DIOB. DIOB can be metabolized to generate reactive metabolites (RMs), which can covalently bind to proteins and lead to hepatoxicity. In the present study, the quantitative method was firstly established for investigating the correlation between DIOB RM-protein adducts (DRPAs) and hepatotoxicity...
March 30, 2023: Drug Metabolism and Pharmacokinetics