Akihiro Fujino, Kanako Kuniyeda, Taiki Nozaki, Michio Ozeki, Tetsuji Ohyama, Iori Sato, Kiyoko Kamibeppu, Akira Tanaka, Naoto Uemura, Kazuhiro Kanmuri, Kenji Nakamura, Fumiaki Kobayashi, Souichi Suenobu, Tadashi Nomura, Ayato Hayashi, Munetomo Nagao, Aiko Kato, Noriko Aramaki-Hattori, Kotaro Imagawa, Kosuke Ishikawa, Junko Ochi, Saya Horiuchi, Hiroshi Nagabukuro
Background: The natural history of venous malformation (VM) and Klippel-Trenaunay Syndrome (KTS) has not been quantitatively studied. To obtain benchmarks to guide designing clinical trials to assess safety and efficacy of novel drug candidates, the clinical course of the patients was followed for 6 months. Methods and Results: This is a multicenter prospective observational study evaluating the change rate in lesion volume from baseline with magnetic resonance images, as the primary endpoint. In addition, disease severities, performance status (PS), pain visual analog scale (VAS) score, quality of life (QoL), infections, and coagulation markers were also evaluated...
December 19, 2023: Lymphatic Research and Biology