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Lymphatic Research and Biology

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https://www.readbyqxmd.com/read/29583078/effectiveness-and-safety-of-treatment-with-direct-oral-anticoagulant-rivaroxaban-in-patients-with-slow-flow-vascular-malformations-a-case-series
#1
Joana M Mack, Gresham T Richter, Shelley E Crary
BACKGROUND: Slow-flow vascular malformations (VM) can be associated with localized intravascular coagulopathy (LIC) that is characterized by elevated D-Dimer levels and low fibrinogen and platelets. This can lead to bleeding and clotting tendencies, which can give rise to functional limitations such as pain and swelling and even progress to disseminated intravascular coagulopathy. METHODS AND RESULTS: We conducted a chart review of four patients with evidence of LIC who were started on rivaroxaban...
March 27, 2018: Lymphatic Research and Biology
https://www.readbyqxmd.com/read/29570430/test-of-responsiveness-and-sensitivity-of-the-questionnaire-lymphedema-quality-of-life-inventory
#2
Pia Klernäs, Aina Johnsson, John Boyages, Håkan Brorson, Alex Munnoch, Karin Johansson
BACKGROUND: Lymphedema may affect patients' health-related quality of life (HRQoL) and thus a disease-specific questionnaire is needed. The Lymphedema Quality of life Inventory (LyQLI) has been tested for reliability and validity. The purpose of this study was to test the LyQLI for responsiveness and sensitivity. METHODS AND RESULTS: The study participants were patients with lymphedema in the upper or lower limb, attending a Swedish rehabilitation program (RP) and undergoing conservative treatment without surgery (RP-sample), or undergoing liposuction (LS) in Australia, Scotland, and Sweden (LS-sample)...
March 23, 2018: Lymphatic Research and Biology
https://www.readbyqxmd.com/read/29659336/update-april-2018
#3
Francine Blei
No abstract text is available yet for this article.
April 2018: Lymphatic Research and Biology
https://www.readbyqxmd.com/read/29659335/lymphatics-and-the-pathogenesis-of-hypertension
#4
Stanley G Rockson
No abstract text is available yet for this article.
April 2018: Lymphatic Research and Biology
https://www.readbyqxmd.com/read/29437542/quality-of-life-questionnaires-in-breast-cancer-related-lymphedema-patients-review-of-the-literature
#5
Anouk J M Cornelissen, Melissa Kool, Xavier H A Keuter, Esther M Heuts, Andrzej A Piatkowski de Grzymala, René R W J van der Hulst, Shan Shan Qiu
PURPOSE: Lymphedema of the arm is one of the most common and underestimated side effects of breast cancer treatment. It is known to negatively affect the quality of life (QoL) in breast cancer survivors. However, there are multiple questionnaires used to measure QoL in lymphedema patients. The current study aimed to determine the most complete and accurate questionnaire. METHODS: A systematic literature search in Cochrane Library database CENTRAL, MEDLINE, and EMBASE was conducted in August 2016 by two independent researchers...
April 2018: Lymphatic Research and Biology
https://www.readbyqxmd.com/read/29346014/role-of-the-lymphatic-system-in-the-pathogenesis-of-hypertension-in-humans
#6
Angelika Chachaj, Bartosz Puła, Mariusz Chabowski, Jędrzej Grzegrzółka, Ewa Szahidewicz-Krupska, Maciej Karczewski, Dariusz Janczak, Piotr Dzięgiel, Marzenna Podhorska-Okołów, Grzegorz Mazur, Andrzej Gamian, Andrzej Szuba
BACKGROUND: Recent studies, mainly on animal models, have suggested that negatively charged glycosaminoglycans, macrophages, and lymph vessels in the skin interstitium may serve as extrarenal control of sodium balance and blood pressure. The aim of the study was to prove the hypothesis that skin interstitium has a role in the pathogenesis of hypertension in humans. METHODS AND RESULTS: We have examined skin biopsies in 91 patients from the department of surgery who had elective surgery with abdominal skin incision: 43 were hypertensive, 14 had resistant hypertension, and 34 with normal blood pressure as control group (median patients' age in these groups estimated accordingly 64 vs...
April 2018: Lymphatic Research and Biology
https://www.readbyqxmd.com/read/29432070/growing-insights-into-breast-cancer-related-lymphedema
#7
Stanley G Rockson
No abstract text is available yet for this article.
February 2018: Lymphatic Research and Biology
https://www.readbyqxmd.com/read/29432069/2017-acknowledgment-of-reviewers
#8
(no author information available yet)
No abstract text is available yet for this article.
February 2018: Lymphatic Research and Biology
https://www.readbyqxmd.com/read/29432068/update-february-2018
#9
Francine Blei
No abstract text is available yet for this article.
February 2018: Lymphatic Research and Biology
https://www.readbyqxmd.com/read/29432067/community-based-treatment-for-chronic-edema-an-effective-service-model
#10
Christine J Moffatt, Debra C Doherty, Peter J Franks, Peter S Mortimer
BACKGROUND: Chronic edema care is patchy and of variable quality internationally. This study was undertaken to develop and evaluate a system of care that would provide for patients within a geographical area of London (Wandsworth), United Kingdom. METHODS AND RESULTS: A prospective cohort design with intervention of a new service design following a 6-month baseline period. Patients were identified through health professionals. A stratified random sample was drawn from all patients and an implementation strategy developed...
February 2018: Lymphatic Research and Biology
https://www.readbyqxmd.com/read/29432066/evaluation-of-ct-changes-in-the-head-and-neck-after-cancer-treatment-development-of-a-measurement-tool
#11
Joseph M Aulino, Elizabeth M Wulff-Burchfield, Mary S Dietrich, Sheila H Ridner, Kenneth J Niermann, Jie Deng, Bethany A Rhoten, Jennifer K Doersam, Lee Ann Jarrett, Kyle Mannion, Barbara A Murphy
BACKGROUND: The late effect continuum of lymphedema and fibrosis (LEF) affects more than 70% of patients after treatment for head and neck cancer (HNC). LEF is associated with symptom burden and decreased function and quality of life. Although surveillance imaging is common posttreatment, objective assessment of soft tissues is not, likely due to the lack of objective evaluation methods and understanding of the significance of LEF. We undertook the development of a tool to measure LEF using CT scans in HNC patients...
February 2018: Lymphatic Research and Biology
https://www.readbyqxmd.com/read/29432065/correction-to-effects-of-aqua-lymphatic-therapy-on-lower-extremity-lymphedema-a-randomized-controlled-study-by-g-ergin-d-karadibak-ho-sener-and-b-gurpinar-lymphatic-research-and-biology-2017-15-3-284-291-doi-10-1089-lrb-2017-0017
#12
https://www.readbyqxmd.com/read/29359999/burn-injury-associated-mhcii-immune-cell-accumulation-around-lymphatic-vessels-of-the-mesentery-and-increased-lymphatic-endothelial-permeability-are-blocked-by-doxycycline-treatment
#13
Walter E Cromer, Scott D Zawieja, Karen M Doersch, Hayden Stagg, Felicia Hunter, Binu Tharakan, Ed Childs, David C Zawieja
It is theorized that toxic agents are transported from the hyperpermeable gut of burn victims through the lymph, to the systemic circulation, causing global injury. We believe that immune cells respond to leakage of "toxic lymph" following trauma causing the attraction of these cells to the perilymphatic space. To test this, we utilized a model of burn on rats to examine changes in a single immune cell population associated with mesenteric lymphatic dysfunction. We examined the ability of serum from these animals to increase permeability in lymphatic endothelial monolayers and disrupt cellular junctions...
February 2018: Lymphatic Research and Biology
https://www.readbyqxmd.com/read/29346025/linkage-of-metabolic-defects-to-activated-pik3ca-alleles-in-endothelial-cells-derived-from-lymphatic-malformation
#14
Kathryn Glaser, Peter Dickie, Derek Neilson, Alexander Osborn, Belinda Hsi Dickie
BACKGROUND: Lymphatic endothelial cells (LECs) derived from lymphatic malformations (LMs) bear activated PIK3CA alleles yet display an inflammatory gene expression profile. A basis for the inflammatory phenotype was sought by screening for coexisting somatic mutations. METHODS AND RESULTS: Fourteen independent LEC populations bearing activated PIK3CA alleles were isolated from LM. These were characterized by the expression of growth and inflammatory genes (VEGFC, IL-6, COX-2, IL-8, HO-1, E-SEL) by qRT-PCR...
February 2018: Lymphatic Research and Biology
https://www.readbyqxmd.com/read/29087763/donor-site-lymphedema-following-lymph-node-transfer-for-breast-cancer-related-lymphedema-a-systematic-review-of-the-literature
#15
Efterpi Demiri, Dimitrios Dionyssiou, Antonios Tsimponis, Olga Christina Goula, Panagiotis Mιlothridis, Leonidas Pavlidis, Georgia Alexandra Spyropoulou, Perikles Foroglou
Abstracts Background: Among current surgical options used for treating breast cancer-related lymphedema (BCRL), autologous lymph node transfer (ALNT) is shown to provide favorable results. However, postoperative donor-site lymphedema (DSL), following the lymphatic flap harvesting from the groin area, has already been reported. Our aim is to summarize the recent literature for evidence of DSL following an ALNT for BCRL. METHODS AND RESULTS: A PubMed bibliographic search was performed for published studies evaluating donor-site complications following LNT in BCRL patients...
February 2018: Lymphatic Research and Biology
https://www.readbyqxmd.com/read/28759307/evaluation-of-stiffness-in-postmastectomy-lymphedema-using-acoustic-radiation-force-impulse-imaging-a-prospective-randomized-controlled-study-for-identifying-the-optimal-pneumatic-compression-pressure-to-reduce-stiffness
#16
Soo Kyung Bok, Yumi Jeon, Jin A Lee, So Young Ahn
PURPOSE: We aimed to assess the improvement in stiffness in patients with postmastectomy lymphedema (PMLE) after intermittent pneumatic compression (IPC) using acoustic radiation force impulse (ARFI) imaging and evaluate the effects of different IPC pressures. METHODS: We randomly assigned 45 patients with PMLE (stage II) to three groups based on the IPC pressure: 25, 35, and 45 mmHg. Patients received a single session of IPC for 30 minutes. We recorded the subcutaneous tissue thickness of the proximal upper limbs using ultrasonography and circumference of the upper limbs and stiffness using ARFI before and immediately after IPC...
February 2018: Lymphatic Research and Biology
https://www.readbyqxmd.com/read/28749716/predilection-to-dermato-lymphangio-adenitis-in-obstructive-lymphedema-of-lower-limbs-depending-on-genetic-polymorphisms-at-tnf%C3%AE-308g-a-ccr2-190g-a-cd14-159c-t-tlr2-2029c-t-tlr4-1063a-g-tlr4-1363c-t-tgf%C3%AE-74g-c-and-tgf%C3%AE-29t-c
#17
Waldemar L Olszewski, Malgorzata Zagozda, Marzanna T Zaleska, Marek Durlik
BACKGROUND: Infection is the most common type of complication observed in lymphedema and is promoted by lymphatic system dysfunction, which causes locoregional immune disorders. Infectious complications are primarily bacterial and most commonly cellulitis (dermato-lymphangio-adenitis, DLA) caused by patients' own skin Staphylococci epidermidis and aureus. The clinical course and outcomes in the immune response to infection have been shown to be associated with genetic polymorphisms. AIM: To investigate polymorphism of TNFα-308G>A, CCR2-190G>A, CD14-159C>T, TLR2 2029C>T, TLR4 1063A>G, TLR4 1363C>T, TGFβ 74G>C, and TGFβ 29T>C...
February 2018: Lymphatic Research and Biology
https://www.readbyqxmd.com/read/28486005/reference-values-for-assessment-of-unilateral-limb-lymphedema-with-dual-energy-x-ray-absorptiometry
#18
Caroline A Gjorup, Helle W Hendel, Tobias W Klausen, Bo Zerahn, Lisbet R Hölmich
INTRODUCTION: The clinical assessment of unilateral limb lymphedema is commonly based on measurements of interlimb volume differences. Reference values for interlimb percentage differences of the volume, fat mass, and lean mass measured with dual-energy X-ray absorptiometry (DXA) scan are, however, not established. The aim of the study was to establish and categorize these reference values in normal limbs. METHODS AND RESULTS: DXA scans of the normal arms of 167 and normal legs of 196 melanoma patients (aged 18-75 years, body mass index <40), respectively, were performed...
February 2018: Lymphatic Research and Biology
https://www.readbyqxmd.com/read/28453410/does-lymphedema-severity-affect-quality-of-life-simple-question-challenging-answers
#19
Teresa S Lee, Carol M Morris, Sharon A Czerniec, Andrea J Mangion
PURPOSE: Lymphedema can have a negative impact on the function and quality of life (QOL) of patients, but most studies have examined lymphedema as a binary variable, rather than a multidimensional disease that ranges in severity. This study explored the potential impact of lymphedema severity on function and overall QOL. METHODS AND RESULTS: Of the 54 lymphedema patients recruited, 40 reported their most severe swelling to be in a limb. These participants underwent bioimpedance measurement (L-Dex® ) and completed either the disabilities of the arm, shoulder, and hand (DASH) questionnaire or the lower extremity functional scale (LEFS)...
February 2018: Lymphatic Research and Biology
https://www.readbyqxmd.com/read/28346864/application-of-the-l-dex-score-for-the-assessment-of-bilateral-leg-edema
#20
Kotaro Suehiro, Noriyasu Morikage, Takasuke Harada, Makoto Samura, Yuriko Takeuchi, Takahiro Mizoguchi, Kaori Nakamura, Kimikazu Hamano
BACKGROUND: We evaluated a modified L-Dex score by using the right arm as a reference (LDSrarm ), to determine whether it could be used for the assessment of leg edema in place of the usual L-Dex score calculated by using the contralateral normal leg as a reference (LDScont ). METHODS: Bioimpedance analysis was performed in the legs and right arms of 38 patients with unilateral leg edema and in 42 healthy volunteers by using a standard equipotential electrode arrangement...
February 2018: Lymphatic Research and Biology
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