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Lymphatic Research and Biology

Janet Douglass, Patricia Graves, Susan Gordon
BACKGROUND: Measurements of tissue compressibility and extracellular fluid (ECF) are used to monitor progression of lymphedema, a chronic swelling of the subcutaneous tissue. Later stages of lymphedema are characterized by fibrotic induration in the subcutis and hyperkeratosis of the skin. Several devices are available to measure these changes, but previous reliability and validity studies have been conducted primarily on adult women with unilateral arm lymphedema using contralateral limbs as controls...
September 27, 2016: Lymphatic Research and Biology
Masahiro Yamashita, Miyuki Niisato, Tomohito Hanasaka, Noriyuki Iwama, Tohru Takahashi, Tamotsu Sugai, Masao Ono, Kohei Yamauchi
BACKGROUND: Limited information is available regarding the lymphatic vasculature during pneumonia. OBJECTIVE: To characterize lymphatic vasculatures in autopsied cadavers with pneumonia. METHODS: Paraffin-embedded lung tissues obtained from 20 autopsied cadavers with complicated pneumonia and 10 control cadavers without pneumonia were used for immunohistochemical analyses using primary antibodies against podoplanin, vascular endothelial growth factor receptor-3 (VEGFR-3), CD34, vascular endothelial growth factor (VEGF)-C, VEGF-D, CD73, and CD163...
September 12, 2016: Lymphatic Research and Biology
Ahmet Akgül, Musa Cirak, Tansu Birinci
Platelet-rich plasma (PRP) is an autologous concentrated preparation of human platelets contained in a small volume of plasma that is characterized by hemostatic and tissue-repairing effects. Being enriched by various kinds of growth factors, and their tissue-repairing effects have made them the focus of attention for use in tissue regeneration. PRP has been safely used and documented in many different fields, including orthopedics, sports injuries, dental and periodontal surgery, and cosmetic, plastic, cardiovascular, general, and maxillofacial surgery...
September 6, 2016: Lymphatic Research and Biology
(no author information available yet)
No abstract text is available yet for this article.
September 2016: Lymphatic Research and Biology
Francine Blei
No abstract text is available yet for this article.
September 2016: Lymphatic Research and Biology
An Tassenoy, Dorien De Strijcker, Nele Adriaenssens, Pierre Lievens
Too often, in clinical settings, the diagnosis and evolution of lymphedema is determined by limb circumference measurements and/or volume calculations. Besides the unrecognition of small lymphedemas, these techniques provide little to no information concerning the stage of the lymphedema. This latter is important in choosing appropriate treatment modalities and making an accurate prognosis. Different imaging techniques are described in literature giving insights in tissue changes due to lymphedema. The aim of this article is giving an overview of possible texture changes linked to the different edema stages, visualized with noninvasive imaging procedures like ultrasonography, computed tomography, dual-energy x-ray absorptiometry, or magnetic resonance imaging...
September 2016: Lymphatic Research and Biology
Judith Nudelman
No abstract text is available yet for this article.
September 2016: Lymphatic Research and Biology
Stanley G Rockson
No abstract text is available yet for this article.
September 2016: Lymphatic Research and Biology
Kotaro Suehiro, Noriyasu Morikage, Osamu Yamashita, Takasuke Harada, Koshiro Ueda, Makoto Samura, Yuya Tanaka, Yuriko Takeuchi, Kaori Nakamura, Kimikazu Hamano
BACKGROUND: This study aimed to determine the specific fluid distribution pattern in legs with lymphedema (LE) in comparison to normal legs and legs with venous edema (VE) using bioelectrical impedance analysis (BIA). METHODS AND RESULTS: BIA was performed in 47 patients with lymphedema (LE; 63 legs), 33 patients with venous edema (VE; 60 legs), and 33 normal subjects (N; 66 legs). The ratio of intracellular fluid (ICF) resistance (Ri) to extracellular fluid (ECF) resistance (Re) of a whole leg normalized to the right arm (Ri/Re leg), a surrogate parameter for ECF/ICF, and the Ri/Re of the thigh and calf without normalization (Ri/Re thigh, Ri/Re calf, respectively) were obtained...
September 2016: Lymphatic Research and Biology
Sun Di, Yu Ziyou, Ning-Fei Liu
BACKGROUND: Skin fibrosis is a clinically serious pathological process of secondary lymphedema (SLE). Previous studies have shown that mast cells (MCs) are involved in lymphedema (LE) and play a key role in the pathological process of skin fibrosis. However, the role of the protease chymase and transforming growth factor-β1 (TGF-β1) secreted by MCs in the fibrotic skins of patients with secondary lower limb LE has not been explored. METHODS AND RESULTS: In this study, full-thickness skin biopsies of lymphedematous limbs from seven SLE patients and control samples from seven healthy controls were harvested...
September 2016: Lymphatic Research and Biology
Hisako Hara, Makoto Mihara, Takashi Anan, Takaya Fukumoto, Mitsunaga Narushima, Takuya Iida, Isao Koshima
BACKGROUND: Sometimes acquired lymphangiectasia (lymphangioma circumscriptum), the pathological mechanism of which is unknown, accompanies lymphedema. The purpose of this study was to better understand the pathological changes present in acquired lymphangiectasia. METHODS AND RESULTS: We examined the pathological characteristics of acquired lymphangiectasia with lymphedema among patients treated at the University of Tokyo Hospital from March 2008 to December 2015...
September 2016: Lymphatic Research and Biology
Frederic Pastouret, David Beckwee, Sigrid Van Laere, Lucia Cardozo, Jan Lamote, Patricia Kranskens, Pierre Lievens
BACKGROUND: Axillary nodes dissection (AND) is an important risk factor for the appearance of breast cancer-related lymphedema (BCRL). The anatomy and pathophysiology leading to the development of BCRL after AND are not completely understood. Despite the existence of lymphedema models after AND, none of them were able to create lymphedemas without additional chemical inflammatory drugs or auxiliary physical techniques (radiotherapy). In this study, we aimed to describe the anatomical changes of AND on a rat's front leg before and after a new surgery technique...
September 2016: Lymphatic Research and Biology
Sharon A Czerniec, Leigh C Ward, Sharon L Kilbreath
BACKGROUND: An understanding of normal fluctuation of lymphedema over time is important to identify real change, whether it is from response to treatment or worsening of the condition. The weather is another factor that possibly influences lymphedema but has had minimal investigation to date. The purpose of this study was to determine the extent to which breast cancer-related lymphedema (BCRL) fluctuated over a 6-month period and the influence of temperature, humidity, and barometric pressure...
September 2016: Lymphatic Research and Biology
Nail Imamoğlu, Didem Karadibak, Gülbin Ergin, Tuğba Yavuzşen
BACKGROUND: The aim of this study was to evaluate the effects of education on the upper extremity functions of patients with lymphedema (LE) after breast cancer treatments. METHODS: Thirty-eight patients with LE after breast cancer treatments participated in the study. The patients were separated into two groups. Group 1 (n = 19) was educated about the causes and symptoms of LE and the methods for minimizing complications from LE, such as skin care, changes that must be made in daily life activities, exercises, and protective clothing...
September 2016: Lymphatic Research and Biology
Sheila H Ridner, Mary S Dietrich, Kenneth Niermann, Anthony Cmelak, Kyle Mannion, Barbara Murphy
BACKGROUND: The purpose of this study was to determine the prevalence and nature of internal, external, and combined lymphedema and fibrosis in patients with head and neck cancer (HNC). MATERIALS AND METHODS: We obtained consent from 100 patients newly diagnosed with having cancer of the head and neck for a 4-year, prospective, longitudinal descriptive study. Recruitment began in August 23, 2010, and the study was completed in April 24, 2014. Eighty-three were evaluated at regular intervals from preradiation therapy to 18 months post-treatment...
June 15, 2016: Lymphatic Research and Biology
Waldemar L Olszewski, Marzanna Zaleska, Sandro Michelin
OBJECTIVES: Edema fluid in lymphedematous limbs should be evacuated to sites where it can be absorbed. It should be moved either to the hypogastrium or arm/scapular regions along tissue channels or implanted silicon channels or through lymphovenous anastomoses. For that purpose, the manual lymphatic drainage of limb is an effective method. Standardization of manual massage applied force and timing becomes necessary. AIM: A device with known pressing area and continuously showing the applied force while moving it toward the root of the limb is needed...
June 7, 2016: Lymphatic Research and Biology
Ke Li, Ningfei Liu, Ziyou Yu, Parviz Sadigh, Davide Lazzeri, Yi Xin Zhang
BACKGROUND: To investigate the therapeutic effect of far infrared rays and compression bandaging in the treatment of chronic lymphedema with dermatolymphangioadenitis (DLA). METHODS: Between 2005 and 2013, 106 patients with chronic lymphedema with DLA treated at the Shanghai Ninth People's Hospital were retrospectively reviewed. These patients were divided into an infrared and a bandaging group (80 patients, group 1) and bandaging only group (26 patients, group 2)...
June 6, 2016: Lymphatic Research and Biology
Mariana Maia Freire de Oliveira, Luis Otávio Sarian, Maria Salete Costa Gurgel, José Geraldo Almeida Filho, Celso Darío Ramos, Laura Ferreira de Rezende, Bárbara Juarez Amorim
OBJECTIVE: To evaluate by lymphoscintigraphy the lymphatic function in the preoperative period up to 2 months after surgery for breast cancer, and the relationship between the lymphatic function with clinical features and physical complications. METHODS: One hundred and five women were studied before and 2 months after surgery to treat breast cancer. On each occasion, inspection and palpation of surgical wound, upper limb circumference, and lymphoscintigraphy were performed...
June 3, 2016: Lymphatic Research and Biology
(no author information available yet)
No abstract text is available yet for this article.
June 2016: Lymphatic Research and Biology
Francine Blei
No abstract text is available yet for this article.
June 2016: Lymphatic Research and Biology
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