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Lymphatic Research and Biology

Caroline A Gjorup, Helle W Hendel, Bo Zerahn, Karin Dahlstroem, Krzysztof T Drzewiecki, Tobias W Klausen, Lisbet Rosenkrantz Hölmich
Abstracts Background: The aim of this cross-sectional study was to investigate the volume, fat mass, and lean mass in both upper and lower limbs measured with dual-energy X-ray absorptiometry (DXA) in melanoma patients with melanoma-related limb lymphedema. METHODS AND RESULTS: Four hundred thirty-one patients who had undergone surgical treatment with wide local excision and unilateral axillary or inguinal sentinel lymph node biopsy and/or complete lymph node dissection participated in a survey, and they underwent clinical examination and measurements of their upper or lower limbs with DXA...
September 8, 2017: Lymphatic Research and Biology
Gulbin Ergin, Didem Karadibak, Hulya Ozlem Sener, Baris Gurpinar
BACKGROUND: The purpose of this study is to investigate the effects of the aqua-lymphatic therapy (ALT) on unilateral lower extremity lymphedema in the maintenance phase. MATERIALS AND METHODS: This is a randomized controlled trial with a blinded assessor. The study was completed with 30 ALT and 27 control group participants. Foot volume was assessed by a water displacement device, limb volume by circumference measurements, functional capacity by a 6-minute walk test, quality of life by Short Form-36, and social appearance by Social Appearance Anxiety Scale and hopeless by Beck Hopeless Scale...
September 7, 2017: Lymphatic Research and Biology
Cheryl Brunelle, Meyha Swaroop, Maria Asdourian, Melissa Skolny, Hoda Sayegh, Alphonse G Taghian
No abstract text is available yet for this article.
September 7, 2017: Lymphatic Research and Biology
Hewei Wang, Ding Li, Jiang Liuya, Elizabeth S Dylke, Leigh C Ward, Jie Jia, Sharon L Kilbreath
BACKGROUND: Bioimpedance is a commonly used technique for detection of early lymphedema. The thresholds used for detection are based on impedance measurements obtained in Western populations. It is unknown whether these thresholds are applicable to a Chinese population. METHODS AND RESULTS: Impedance measurements were obtained for both arms in 391 women, ranging in age from 20 to 84 years, using a standardized protocol. Frequency distributions of interlimb impedance arm ratios for both dominant:non-dominant and non-dominant:dominant were used to determine thresholds at two and three standard deviations (SDs) above the mean...
September 7, 2017: Lymphatic Research and Biology
Judith Nudelman
No abstract text is available yet for this article.
September 7, 2017: Lymphatic Research and Biology
Jung Ho Lee, David W Chang
Primary lymphedema is due to abnormal congenital development or dysfunction in the lymphatic system. Limited data exist on the prevalence of primary lymphedema and there are only few studies focusing on primary lymphedema. The purpose of this article is to review the current options for surgical treatment of primary lymphedema.
September 7, 2017: Lymphatic Research and Biology
Marzanna T Zaleska, Waldemar L Olszewski
BACKGROUND: Lymphedema of limbs affects a large mass of tissues. Pathological changes develop in skin and subcutaneous tissue. Bacterial retention in edema fluid is followed by chronic inflammatory reaction. The question arises whether the chronic processes affecting a large mass of limb tissues are reflected in the serum by appearance of specific proteins accumulating and subsequently absorbed from the lymphedematous tissues Aim: To measure the concentration of serum proteins (1) participating in cellular disintegration such as caspase 1, sFas, high-mobility group box 1 (HMGB1), and serpin, (2) cell growth regulating factors such as cortisol, human growth hormone, keratinocyte growth factor, and insulin-like growth factor (IGF), and (3) angiogenic and growth factors such as angiopoetins 1 and 2, adiponectin, leptin, and transforming growth factor beta...
September 7, 2017: Lymphatic Research and Biology
Elizabeth S Dylke, Helen Benincasa Nakagawa, Lanni Lin, Jillian L Clarke, Sharon L Kilbreath
BACKGROUND: Lymphedema of the breast, secondary to treatment for breast cancer, is difficult to assess due to the shape of the breast and the nature of the tissue. Ultrasound measurement of dermal thickness has been previously used to assess breast swelling; however, the reliability of the measurements, or what should be considered an abnormal thickness, is currently known. METHODS AND RESULTS: Thirty-eight women with breast edema were recruited and underwent assessment using ultrasound...
July 31, 2017: Lymphatic Research and Biology
Randolfo Fernández Peñuela, Gemma Pons Playa, Laura Casaní Arazo, Jaume Masiá Ayala
BACKGROUND: The lymphatic system is the least studied of the body's systems, and as a result its contribution to human health and diseases is not well known. The failure of the lymphatic system to drain extravasated fluid efficiently leads to accumulation of lymph in the interstitial tissue, thus causing lymphedema. Despite developments in microsurgery procedures, the results of lymphedema treatment remain disappointing. The aim of this study was to develop an experimental animal model that is able to reproduce the disease and to apply various surgical and therapeutic approaches...
July 31, 2017: Lymphatic Research and Biology
Jeffrey Cheng, Beiyu Liu, Alfredo E Farjat, Jonathan Routh
OBJECTIVE: Describe inpatient resource utilization trends in children with lymphatic malformations using a national database. DATA SOURCE: Kids' inpatient database, years 2000-2009. METHODS: Subjects included children 18 years and under with International Classification of Diseases (ICD), 9th revision code: 228.1-lymphangioma, any site. Data elements were extracted and used to calculate related inpatient costs and trended over time. RESULTS: No significant increase in admission rates was noted over time, p = 0...
July 31, 2017: Lymphatic Research and Biology
Marzanna T Zaleska, Waldemar L Olszewski, Marek Durlik, Mariusz K Kaczmarek, Bob Freidenrich
BACKGROUND: The therapeutic intermittent pneumatic compression (IPC) pressures are usually set arbitrarily at levels between 40 and 60 mmHg. However, it is not known how much force has been transferred to edema fluid. There is a need to know how high edema fluid pressures should be generated to evacuate the stagnant fluid. The externally applied compression force dissipates in hard tissues and only a portion of it is conveyed to tissue fluid. Simultaneous measuring of compression force using deep tissue tonometry and recording edema fluid pressures under a tonometer would give hints of how high should therapist or patient set IPC pressures to mobilize fluid...
July 31, 2017: Lymphatic Research and Biology
Soo Kyung Bok, Yumi Jeon, Jin A Lee, So Young Ahn
PURPOSE: We aimed to assess the improvement in stiffness in patients with postmastectomy lymphedema (PMLE) after intermittent pneumatic compression (IPC) using acoustic radiation force impulse (ARFI) imaging and evaluate the effects of different IPC pressures. METHODS: We randomly assigned 45 patients with PMLE (stage II) to three groups based on the IPC pressure: 25, 35, and 45 mmHg. Patients received a single session of IPC for 30 minutes. We recorded the subcutaneous tissue thickness of the proximal upper limbs using ultrasonography and circumference of the upper limbs and stiffness using ARFI before and immediately after IPC...
July 31, 2017: Lymphatic Research and Biology
Catalina Lopera, Peter R Worsley, Dan L Bader, Deborah Fenlon
BACKGROUND: Lymphedema is a chronic peripheral swelling caused by a dysfunction of the lymphatic system, leading to discomfort and loss of upper limb movement. Therapies to treat or manage this swelling have limited evidence, partly because of a paucity in objective lymphatic measures. This study explored the role of near-infrared (NIR) imaging in evaluating interventions. METHODS: Nine healthy volunteers underwent NIR fluoroscopy using a microdose (50 μL, 0...
July 27, 2017: Lymphatic Research and Biology
Sinéad T Morley, Michael T Walsh, David T Newport
The lymphatic system serves as the primary route for the metastatic spread of breast cancer cells (BCCs). A scarcity of information exists with regard to the advection of BCCs in lymph flow and a fundamental understanding of the response of BCCs to the forces in the lymphatics needs to be established. This review summarizes the flow environment metastatic BCCs are exposed to in the lymphatics. Special attention is paid to the behavior of cells/particles in microflows in an attempt to elucidate the behavior of BCCs under lymph flow conditions (Reynolds number <1)...
July 27, 2017: Lymphatic Research and Biology
Masaya Akashi, Shun Teraoka, Yasumasa Kakei, Junya Kusumoto, Takumi Hasegawa, Tsutomu Minamikawa, Kazunobu Hashikawa, Takahide Komori
BACKGROUND: This study aimed to evaluate posttreatment soft-tissue changes in patients with oral cancer with computed tomography (CT). To accomplish that purpose, a scoring system was established, referring to the criteria of lower leg lymphedema (LE). METHODS AND RESULTS: One hundred and six necks in 95 patients who underwent oral oncologic surgery with neck dissection (ND) were analyzed retrospectively using routine follow-up CT images. A two-point scoring system to evaluate soft-tissue changes (so-called "LE score") was established as follows: Necks with a "honeycombing" appearance were assigned 1 point...
July 27, 2017: Lymphatic Research and Biology
Yeşim Bakar, Alper Tuğral, Ümmügül Üyetürk
BACKGROUND: Studies revealed that having "1.20" or upper interarm local tissue water (LTW) ratio which can be calculated through tissue dielectric constant (TDC) method might be the determinant of clinical lymphedema after breast cancer surgery. The purpose of this study was to confirm these findings and determine the sensitivity and specificity of LTW (%) measurement method in patients with breast cancer related lymphedema (BCRL). METHODS AND RESULTS: Sixty-three participants were recruited to this study in two groups as follows: the lymphedema group (n = 32), who had BCRL after breast cancer surgery, and the latent group (n = 31), who had breast cancer surgery yet having no lymphedema...
July 27, 2017: Lymphatic Research and Biology
Jacob Hinnerup Groenlund, Niklas Telinius, Soeren Nielsen Skov, Vibeke Hjortdal
BACKGROUND: Near-infrared fluorescence (NIRF) imaging is a new imaging technique that is used to visualize lymphatic vessels in humans. It has a high spatial and temporal resolution, allowing real-time visualization of lymphatic flow. METHODS AND RESULTS: The current study investigated the intra- and inter-individual variability of the technique, and how local hypo- and hyperthermia (20°C, 40°C), as well as exercise affect lymph transport. In this study, 10 healthy volunteers were studied twice, with 2 weeks between...
July 27, 2017: Lymphatic Research and Biology
Hewei Wang, Li Shen, Tao Liu, Peng Shao, Elizabeth S Dylke, Jie Jia, Sharon L Kilbreath
BACKGROUND: Detection of upper limb lymphedema following treatment for breast cancer typically relies on interlimb circumference-based differences. Normative-determined criteria from an Australian population have high sensitivity and specificity for detection of mild lymphedema in Australian women. It is unknown whether these criteria are applicable to Chinese women whose body habitus is different from Australian women. The aims of this study, therefore, were to determine the normative-based interlimb circumference and volume differences in a Chinese population and whether specific population-based thresholds are required...
July 27, 2017: Lymphatic Research and Biology
Waldemar L Olszewski, Malgorzata Zagozda, Marzanna T Zaleska, Marek Durlik
BACKGROUND: Infection is the most common type of complication observed in lymphedema and is promoted by lymphatic system dysfunction, which causes locoregional immune disorders. Infectious complications are primarily bacterial and most commonly cellulitis (dermato-lymphangio-adenitis, DLA) caused by patients' own skin Staphylococci epidermidis and aureus. The clinical course and outcomes in the immune response to infection have been shown to be associated with genetic polymorphisms. AIM: To investigate polymorphism of TNFα-308G>A, CCR2-190G>A, CD14-159C>T, TLR2 2029C>T, TLR4 1063A>G, TLR4 1363C>T, TGFβ 74G>C, and TGFβ 29T>C...
July 27, 2017: Lymphatic Research and Biology
Kotaro Suehiro, Noriyasu Morikage, Osamu Yamashita, Takasuke Harada, Makoto Samura, Yuriko Takeuchi, Takahiro Mizoguchi, Kaori Nakamura, Kimikazu Hamano
BACKGROUND: Both subcutaneous echo-free space (SEFS) observed by ultrasonography and the ratio of intracellular fluid resistance to extracellular fluid resistance (Ri/Re) calculated from bioelectrical impedance analysis (BIA) represent extracellular edema status in the extremities. We tried to correlate these parameters. METHODS AND RESULTS: In 70 legs with venous edema (VE) and 68 legs with lymphedema (LE), subcutaneous tissue ultrasonography to determine SEFS severity (range, 0-2) and BIA to calculate Ri/Re were performed...
June 2017: Lymphatic Research and Biology
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