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Lymphatic Research and Biology

Emi Komatsu, Yukari Nakajima, Kanae Mukai, Tamae Urai, Kimi Asano, Mayumi Okuwa, Junko Sugama, Toshio Nakatani
BACKGROUND: Although lymphedematous skin exhibits delayed wound healing, little is known about lymph drainage during wound healing. We investigated the wound healing process in the presence of lymphatic dysfunction. METHODS AND RESULTS: The right inguinal lymph nodes (iLNs) and the surrounding tissue were excised in each mouse (the operation side), and a sham operation was performed in the left hindlimb (the control side). The next day, full-thickness wounds were made on both hindlimbs...
February 2, 2017: Lymphatic Research and Biology
Fabio Torri, Patrizia Dell'Era, Emirena Garrafa
BACKGROUND: Relatively few attempts have been made to set up an assay that allows the measurement of lymphatic endothelial cells (LECs) motility. Nowadays, the most widely used methods involve adaptation of the Boyden chamber method or the wound scratch assay, both of them showing some limitations due to long and expensive setup and high variability. METHODS AND RESULTS: We propose a new, economic, and easy to setup LEC Motility (ELM) assay that will contribute to the study of lymphangiogenesis...
January 30, 2017: Lymphatic Research and Biology
Shirin M Shallwani, Pamela Hodgson, Anna Towers
BACKGROUND: Lymphedema is an irreversible inflammatory condition caused by accumulated lymph fluid and is associated with chronic swelling and increased risk of cellulitis. Our objectives were to: (1) describe the patient population referred to a Canadian lymphedema center and (2) compare lymphedema characteristics between patients with cancer and patients with noncancer diagnoses. METHODS AND RESULTS: A retrospective cohort study was conducted of new patients referred for suspected lymphedema to a hospital-based center over a 2-year period...
January 30, 2017: Lymphatic Research and Biology
Ke Li, Peiru Min, Parviz Sadigh, Luca Grassetti, Davide Lazzeri, Matteo Torresetti, Riccardo Marsili, Shaoqing Feng, Ningfei Liu, Yi Xin Zhang
BACKGROUND: The increases in capillary wall permeability and capillary hydrostatic pressure are considered to be the causes for the acute swelling seen in flaps; however, disruption of the circulating flap lymphatics could be another contributory factor. In this study we monitor the development of flap edema in a series of 18 prefabricated flaps and aim to delineate the natural history of this phenomenon by use of lymphography. METHODS: Postoperative swelling was monitored in a series of 18 pre-expanded prefabricated cervical skin flaps used for hemi-facial burns-scar resurfacing...
January 30, 2017: Lymphatic Research and Biology
Mattias Hoffner, Shirin Bagheri, Emma Hansson, Jonas Manjer, Thomas Troëng, Håkan Brorson
: Abstracts Background: Arm lymphedema after breast cancer surgery affects women both from physical and psychological points of view. Lymphedema leads to adipose tissue deposition. Liposuction and controlled compression therapy (CCT) reduces the lymphedema completely. METHODS AND RESULTS: Sixty female patients with arm lymphedema were followed for a 1-year period after surgery. The 36-item short-form health survey (SF-36) was used to assess health-related quality of life (HRQoL)...
January 30, 2017: Lymphatic Research and Biology
Rebecca Hadrian, Daniel Palmes
Secondary lymphedema is still a worldwide problem. Symptomatic approaches to lymphedema therapy have been mainly used, with complete decongestive therapy as the cornerstone. Due to a lack of regenerative therapy, researchers have established various animal models to obtain insights into pathomechanisms and to reveal the best therapeutic option. Since the first reproducible and reliable animal model of lymphedema was reported in dogs, the technique of circumferential excision of lymphatic tissue has been translated mainly to rodents to induce secondary lymphedema...
January 27, 2017: Lymphatic Research and Biology
Stanley G Rockson
No abstract text is available yet for this article.
December 2016: Lymphatic Research and Biology
Francine Blei
No abstract text is available yet for this article.
December 2016: Lymphatic Research and Biology
(no author information available yet)
No abstract text is available yet for this article.
December 2016: Lymphatic Research and Biology
Masahiro Yamashita, Miyuki Niisato, Tomohito Hanasaka, Noriyuki Iwama, Tohru Takahashi, Tamotsu Sugai, Masao Ono, Kohei Yamauchi
BACKGROUND: Limited information is available regarding the lymphatic vasculature during pneumonia. OBJECTIVE: To characterize lymphatic vasculatures in autopsied cadavers with pneumonia. METHODS: Paraffin-embedded lung tissues obtained from 20 autopsied cadavers with complicated pneumonia and 10 control cadavers without pneumonia were used for immunohistochemical analyses using primary antibodies against podoplanin, vascular endothelial growth factor receptor-3 (VEGFR-3), CD34, vascular endothelial growth factor (VEGF)-C, VEGF-D, CD73, and CD163...
December 2016: Lymphatic Research and Biology
Ahmet Akgül, Musa Cirak, Tansu Birinci
Platelet-rich plasma (PRP) is an autologous concentrated preparation of human platelets contained in a small volume of plasma that is characterized by hemostatic and tissue-repairing effects. Being enriched by various kinds of growth factors, and their tissue-repairing effects have made them the focus of attention for use in tissue regeneration. PRP has been safely used and documented in many different fields, including orthopedics, sports injuries, dental and periodontal surgery, and cosmetic, plastic, cardiovascular, general, and maxillofacial surgery...
December 2016: Lymphatic Research and Biology
Sheila H Ridner, Mary S Dietrich, Kenneth Niermann, Anthony Cmelak, Kyle Mannion, Barbara Murphy
BACKGROUND: The purpose of this study was to determine the prevalence and nature of internal, external, and combined lymphedema and fibrosis in patients with head and neck cancer (HNC). MATERIALS AND METHODS: We obtained consent from 100 patients newly diagnosed with having cancer of the head and neck for a 4-year, prospective, longitudinal descriptive study. Recruitment began in August 23, 2010, and the study was completed in April 24, 2014. Eighty-three were evaluated at regular intervals from preradiation therapy to 18 months post-treatment...
December 2016: Lymphatic Research and Biology
Waldemar L Olszewski, Marzanna Zaleska, Sandro Michelin
OBJECTIVES: Edema fluid in lymphedematous limbs should be evacuated to sites where it can be absorbed. It should be moved either to the hypogastrium or arm/scapular regions along tissue channels or implanted silicon channels or through lymphovenous anastomoses. For that purpose, the manual lymphatic drainage of limb is an effective method. Standardization of manual massage applied force and timing becomes necessary. AIM: A device with known pressing area and continuously showing the applied force while moving it toward the root of the limb is needed...
December 2016: Lymphatic Research and Biology
Ke Li, Ningfei Liu, Ziyou Yu, Parviz Sadigh, Davide Lazzeri, Yi Xin Zhang
BACKGROUND: To investigate the therapeutic effect of far infrared rays and compression bandaging in the treatment of chronic lymphedema with dermatolymphangioadenitis (DLA). METHODS: Between 2005 and 2013, 106 patients with chronic lymphedema with DLA treated at the Shanghai Ninth People's Hospital were retrospectively reviewed. These patients were divided into an infrared and a bandaging group (80 patients, group 1) and bandaging only group (26 patients, group 2)...
December 2016: Lymphatic Research and Biology
Mariana Maia Freire de Oliveira, Luis Otávio Sarian, Maria Salete Costa Gurgel, José Geraldo Almeida Filho, Celso Darío Ramos, Laura Ferreira de Rezende, Bárbara Juarez Amorim
OBJECTIVE: To evaluate by lymphoscintigraphy the lymphatic function in the preoperative period up to 2 months after surgery for breast cancer, and the relationship between the lymphatic function with clinical features and physical complications. METHODS: One hundred and five women were studied before and 2 months after surgery to treat breast cancer. On each occasion, inspection and palpation of surgical wound, upper limb circumference, and lymphoscintigraphy were performed...
December 2016: Lymphatic Research and Biology
Janet Douglass, Patricia Graves, Susan Gordon
BACKGROUND: Measurements of tissue compressibility and extracellular fluid (ECF) are used to monitor progression of lymphedema, a chronic swelling of the subcutaneous tissue. Later stages of lymphedema are characterized by fibrotic induration in the subcutis and hyperkeratosis of the skin. Several devices are available to measure these changes, but previous reliability and validity studies have been conducted primarily on adult women with unilateral arm lymphedema using contralateral limbs as controls...
September 27, 2016: Lymphatic Research and Biology
(no author information available yet)
No abstract text is available yet for this article.
September 2016: Lymphatic Research and Biology
Francine Blei
No abstract text is available yet for this article.
September 2016: Lymphatic Research and Biology
An Tassenoy, Dorien De Strijcker, Nele Adriaenssens, Pierre Lievens
Too often, in clinical settings, the diagnosis and evolution of lymphedema is determined by limb circumference measurements and/or volume calculations. Besides the unrecognition of small lymphedemas, these techniques provide little to no information concerning the stage of the lymphedema. This latter is important in choosing appropriate treatment modalities and making an accurate prognosis. Different imaging techniques are described in literature giving insights in tissue changes due to lymphedema. The aim of this article is giving an overview of possible texture changes linked to the different edema stages, visualized with noninvasive imaging procedures like ultrasonography, computed tomography, dual-energy x-ray absorptiometry, or magnetic resonance imaging...
September 2016: Lymphatic Research and Biology
Judith Nudelman
No abstract text is available yet for this article.
September 2016: Lymphatic Research and Biology
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