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Lymphatic Research and Biology

David P Perrault, Gene K Lee, Sun Young Park, Sunju Lee, Dongwon Choi, Eunson Jung, Young Jin Seong, Eun Kyung Park, Cynthia Sung, Roy Yu, Antoun Bouz, Austin Pourmoussa, Soo Jung Kim, Young-Kwon Hong, Alex K Wong
BACKGROUND: The fibroblast growth factor receptor (FGFR) family includes transmembrane receptors involved in a wide range of developmental and postdevelopmental biologic processes as well as a wide range of human diseases. In particular, FGFR3 has been implicated in the mechanism by which 9-cis retinoic acid (9-cisRA) induces lymphangiogenesis and improves lymphedema. The purpose of this study was to validate the efficacy of a novel small peptide FGFR3 inhibitor, peptide P3 (VSPPLTLGQLLS), and to elucidate the role of FGFR3 in 9-cisRA-induced lymphangiogenesis using this peptide...
January 16, 2019: Lymphatic Research and Biology
Nele Devoogdt, Claudia Cavaggion, Elien Van der Gucht, Lore Dams, An De Groef, Mira Meeus, Roxane Van Hemelrijck, Anneleen Heynen, Sarah Thomis, Ceren Orhan
BACKGROUND: To compare interrater reliability and the time-efficiency for the water displacement method, figure-of-eight method, and circumference measurements of the ankle and foot, and to investigate concurrent validity of the figure-of-eight method and circumference measurements with the water displacement method. METHODS AND RESULTS: Thirty patients (21 women and 9 men) with primary or secondary lower limb lymphedema were evaluated twice. The volume of the foot and ankle was measured in three different ways: water displacement with a volumeter, figure-of-eight method, and circumference measurements at the level of the malleoli and metatarsals with a tapeline...
January 16, 2019: Lymphatic Research and Biology
Emily Iker, Cory K Mayfield, Daniel J Gould, Ketan M Patel
BACKGROUND: Sonographic findings differ in patients with primary lipedema from those with lymphedema. This project was designed to quantify those differences and objectively characterize findings of lipedema and lymphedema in the lower extremity. METHODS AND RESULTS: Patients with a clinical diagnosis of ISL stage I-II lipedema or lower extremity lymphedema that received ultrasound evaluation were included in this study. Thickness and echogenicity of the skin and subcutaneous fat layer were measured at the level of the ankle, calf, and thigh in each patient...
January 7, 2019: Lymphatic Research and Biology
Esra Giray, İlker Yağcı
BACKGROUND: Subcutaneous echogenicity grade (SEG) and subcutaneous echo-free space (SEFS) grade allow semiquantitation of nonspecific subcutaneous tissue inflammation and fluid accumulation in breast cancer-related lymphedema. However, inter- and intrarater reliability of SEG and SEFS is yet to be reported. The objective of this study is to assess inter-rater and intrarater reliability of SEG and SEFS in patients with breast cancer-related lymphedema. METHODS AND RESULTS: Two physiatrists performed SEG and SEFS grade to determine inter-rater and intrarater reliability...
December 20, 2018: Lymphatic Research and Biology
Afaq Hameed, Mahalakshmi Natarajan, Salih Jabbar, Jeeva Jothi Dhanasekaran, Krishna Kumar, Sanjana Sivanesan, Michael Kron, Anuradha Dhanasekaran
BACKGROUND: Lymphatic filariasis (LF) is a global health problem, with a peculiar nature of parasite-specific immunosuppression that promotes long-term pathology and disability. Immune modulation in the host by parasitic antigens is an integral part of this disease. The current study attempts to dissect the immune responses of aminoacyl-tRNA synthetases (AARS) with emphasis on Brugia malayi asparaginyl-tRNA synthetase (BmAsnRS), since it is one among the highly expressed excretory/secretory proteins expressed in all stages of the parasite life cycle, whereas its role in filarial pathology has not been elaborately studied...
December 20, 2018: Lymphatic Research and Biology
David B Spenciner, F Alan Barber, Brett G Zani, Raffaele Melidone, Timothy R Muench
BACKGROUND: Intra-articular wear particulate migration from the knee joint has been studied in various animal models as well as postmortem in patients who received total knee joint replacement. However, there still exists a need for a simple, yet analogous animal model for tracking the migration of wear debris from the knee joint, especially through the draining lymph nodes. METHODS AND RESULTS: To fill this need, a proof-of-concept porcine model was developed for particle migration from the knee joint into the surrounding lymphatic system...
December 19, 2018: Lymphatic Research and Biology
Rebecca M Garza, Adrian S H Ooi, Joshua Falk, David W Chang
BACKGROUND: Multiple staging systems for classifying the severity of lymphedema exist. The International Society of Lymphology (ISL) stage is considered standard for clinical reporting, but the relationship between clinical and functional/imaging stage remains poorly defined. MATERIALS AND METHODS: We reviewed the prospectively collected data of all patients who underwent physiologic lymphedema surgery for a 3-year period by the senior author. Patients who underwent preoperative clinical staging with limb volume calculations and intraoperative indocyanine green (ICG) staging were included...
December 18, 2018: Lymphatic Research and Biology
Sarah M DeSnyder, Parviz Kheirkhah, Marigold L Travis, Susan E Lilly, Isabelle Bedrosian, Thomas A Buchholz, Mark V Schaverien, Simona F Shaitelman
BACKGROUND: Prospective lymphedema screening is recommended for breast cancer patients. We observed interoperator variation in perometer-acquired arm volume measurements (P-AVMs) due to patient instability during measurements. We hypothesized that improved positioning during perometry would reduce P-AVM variability. METHODS AND RESULTS: Each arm was measured three times by each operator using a perometer. With the original configuration, P-AVM was performed by 2 operators in 30 patients and four cohorts of 5 to 6 operators in 5 volunteers...
December 18, 2018: Lymphatic Research and Biology
Joonmyeong Choi, Kun Yung Kim, Jae Yong Jeon, Sung Hwan Yoon, Jung-Hoon Park, Ho-Young Song, Kyu-Jin Cho
BACKGROUNDS: Secondary lymphedema is a common complication of parasitization and breast or gynecologic cancer therapy; however, options for the treatment of lymphedema are ineffective and limited. A mouse tail model is one of the most successful animal models for a lymphatic study. Lymphedema of the mouse tail is characterized by increases in the volume of the extremity caused by accumulation of tissue fluid, proliferation of fibroblasts and adipocytes, and excessive production of collagen...
December 18, 2018: Lymphatic Research and Biology
Aslı Gençay Can, Emel Ekşioğlu, Fatma Aytül Çakçı
BACKGROUND: Early identification and treatment of subclinical lymphedema may prevent development of advanced stages and its related complications. We aimed to detect subclinical lymphedema and to evaluate the effects of early treatment program on the development of clinical lymphedema, upper extremity functions, and quality of life in patients with subclinical lymphedema. METHODS AND RESULTS: Twenty-five women who were diagnosed having subclinical lymphedema were enrolled in the study...
December 13, 2018: Lymphatic Research and Biology
Murat Esmer, Ilke Keser, Dilek Erer, Buse Kupeli
BACKGROUND: The purpose of this study was to investigate acute cardiovascular responses to manual lymphatic drainage (MLD) on different parts of the body. MATERIALS AND METHODS: Thirty healthy individuals (10 women and 20 men) participated in the study voluntarily. Heart rate (HR), systolic blood pressure (SBP), diastolic blood pressure (DBP), respiration frequency, and oxygen saturation were measured before and after MLD was applied to different regions of the body (neck, abdomen, anastomosis, arm, and leg)...
December 11, 2018: Lymphatic Research and Biology
Harvey N Mayrovitz, Alexander Mikulka, Don Woody
BACKGROUND: Tissue dielectric constant (TDC) measurements are increasingly being used as a tool to help characterize lymphedema features, detect its presence, and assess treatment related changes. Although the underlying physics of this technology has been well described in the literature, there has been little systematic study of in vivo reliability aspects. A central unanswered question is the minimal detectable change (MDC) that, with a given level of confidence, may be ascribed to this technology...
December 8, 2018: Lymphatic Research and Biology
Sheila H Ridner, Mary S Dietrich, Stephen T Sonis, Barbara Murphy
BACKGROUND: This study examined interrelationships of selected interleukins (ILs), tumor growth factors, matrix metalloproteinases (MMPs), and C-reactive protein, interferon-gamma (IFN-γ), and tumor necrosis factor α (TNF-α) with lymphedema/fibrosis in patients with head and neck cancer (HNC). METHODS AND RESULTS: Patients newly diagnosed with ≥Stage II HNC (N = 100) were assessed for external/internal lymphedema and/or fibrosis before treatment, end-of-treatment, and at regularly established intervals through 72 weeks posttreatment and blood was drawn...
November 28, 2018: Lymphatic Research and Biology
Giuseppe Noia, Paolo Enrico Maltese, Giuseppe Zampino, Marco D'Errico, Vittoria Cammalleri, Paolo Convertini, Giuseppe Marceddu, Martina Mueller, Giulia Guerri, Matteo Bertelli
BACKGROUND: The objective of this study is to examine the hypothesis that cystic hygroma (CH) with normal karyotype can manifest as a Mendelian inherited trait, and that a genetic similitude with hereditary lymphedema exists. To reach this goal, we investigated the prevalence of genetic variants in angiogenesis and lymphangiogenesis genes in a cohort of euploid fetuses with CH that almost resolved before delivery. A short review of cases from literature is also reported. METHODS AND RESULTS: Five fetuses were screened using a next-generation sequencing approach by targeting 33 genes known to be associated with vascular and lymphatic malformations...
November 22, 2018: Lymphatic Research and Biology
Hideki Tokumoto, Shinsuke Akita, Motone Kuriyama, Nobuyuki Mitsukawa
PURPOSES: Conventionally, lower limb circumference is measured using a measuring tape; however, a measuring tape may not provide sufficient precision to measure the magnitude of the lymphedema. We report the use of three-dimensional photography (VECTRA® ) for the evaluation of lymphedema in patients after lymphovenous anastomosis (LVA). METHODS: We calculated the percent error in measuring lower limb circumference with a measuring tape. We performed VECTRA before and after LVA and measured the change in volume...
November 14, 2018: Lymphatic Research and Biology
Linda A Koehler, Harvey N Mayrovitz
BACKGROUND: Tissue dielectric constant (TDC), as an index of local tissue water, and girth measurements are quantitative methods to measure and characterize lymphedema. OBJECTIVE: To describe the spatial and temporal variability in arm girth and TDC values in women surgically treated for breast cancer and to describe the relationship between these measures. METHODS AND RESULTS: This was a prospective longitudinal study that observed 36 women for 78 weeks after breast cancer surgery with lymph node removal...
November 14, 2018: Lymphatic Research and Biology
Christopher J Coroneos, Franklin C Wong, Sarah M DeSnyder, Simona F Shaitelman, Mark V Schaverien
BACKGROUND: Bioimpedance spectroscopy (BIS) is an established tool for the measurement of extracellular fluid in lymphedema. This study assesses the validity of BIS measurements using the l-Dex® for evaluating the effectiveness of interventions to treat lymphedema. Measurements are correlated with limb volume, assessment of pitting edema, physiologic measures of lymphatic function, and response to surgical intervention. Three l-Dex BIS metrics are compared. METHODS AND RESULTS: This retrospective study of prospectively collected data identified consecutive patients with lymphedema...
November 2, 2018: Lymphatic Research and Biology
Sheila H Ridner, Jennifer K Doersam, Deonni P Stolldorf, Mary S Dietrich
BACKGROUND: Lymphedema is a chronic, incurable condition that occurs most commonly in lower limbs (legs and feet). Increased morbidity is seen with this form of lymphedema, but there are few studies and even fewer tools intended to assess symptom burden in patients impacted by this condition. A questionnaire, the Lymphedema Symptom Intensity and Distress Survey-Lower Limb (LSIDS-L), was developed to fill this gap. The measure is composed of several clusters of symptoms thought to characterize lower limb lymphedema...
October 24, 2018: Lymphatic Research and Biology
Shan Liao, Echoe M Bouta, Linda M Morris, Dennis Jones, Rakesh K Jain, Timothy P Padera
BACKGROUND: Metastatic tumor cells spread through lymphatic vessels and colonize draining lymph nodes (LNs). It is known that tumors induce lymphangiogenesis to enhance lymphatic metastasis and that metastatic cancer cells are carried by lymph flow to LNs. METHODS AND RESULTS: Here, we investigated the molecular and cellular regulation of collecting lymphatic vessel contraction in vessels draining a metastatic tumor using intravital microscopy. In tumor-draining collecting lymphatic vessels, we found vessel contraction was suppressed...
October 24, 2018: Lymphatic Research and Biology
Joël Visser, Michel van Geel, Anouk J M Cornelissen, René R W J van der Hulst, Shan Shan Qiu
BACKGROUND: Secondary lymphedema is a complication following breast cancer therapy and constitutes the main form of lymphedema in the western world. The purpose of the current study was to provide a clear overview of the genetic predisposition and secondary lymphedema. METHODS AND RESULTS: A systematic search was performed between February and June 2017 in MEDLINE and Embase. Search terms included Genes, Genetic Predisposition to Disease, Lymphedema, Breast Cancer Lymphedema, Secondary Lymphedema, Breast Cancer-Related Lymphedema, and Humans...
October 24, 2018: Lymphatic Research and Biology
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