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Lymphatic Research and Biology

Susanne Wiegand, Gunnar Wichmann, Andreas Dietz
BACKGROUND: Extensive lymphatic malformations are low-flow vascular malformations that can cause devastating complications. Treatment of these malformations is challenging. This systematic review presents current use of sirolimus in patients with extensive lymphatic malformations. METHODS: MEDLINE and Google scholar search was conducted for studies on sirolimus treatment of lymphatic malformations up to July 2017. Search items included "lymphatic malformation," "lymphangioma," "cystic hygroma," "vascular malformation," "low-flow malformation," "sirolimus," "rapamycin," and "mTOR inhibitor...
June 20, 2018: Lymphatic Research and Biology
Jin A Yoon, Yong Beom Shin, Myung Jun Shin, Ra Yu Yun, Keun Young Kim, You Sun Song, Youngtae Bae, Seokwon Lee, Younglae Jung, Sang Hyun Lee
BACKGROUND: Obesity is one of the well-known initiating and aggravating factors of lymphedema. Body mass index (BMI) is typically used to define obesity, but in Asian populations, health risks are elevated at lower BMI levels, and abdominal fat may be a better obesity metric. Thus, we assessed the potential association between abdominal obesity and lymphedema severity in postoperative breast cancer patients. METHODS AND RESULTS: Thirty-three women with breast cancer-related lymphedema participated in this study...
June 5, 2018: Lymphatic Research and Biology
Megumi Kishimoto, Masaya Akashi, Yasumasa Kakei, Junya Kusumoto, Akiko Sakakibara, Takumi Hasegawa, Shungo Furudoi, Ryohei Sasaki, Takahide Komori
BACKGROUND: A problematic complication after radiation therapy is lymphedema. Development of lymphedema is associated with an increase in lymphatic paracellular permeability. The current study investigated the effects of radiation on intercellular junctions and paracellular permeability in cultured human dermal lymphatic endothelial cells (HDLECs). METHODS AND RESULTS: Double immunofluorescence staining with vascular endothelial (VE)-cadherin and actin immediately after X-ray irradiation (5 or 20 Gy) was performed...
June 4, 2018: Lymphatic Research and Biology
Harvey N Mayrovitz, Evelina Arzanova, Scarlett Somarriba, Samar Eisa
BACKGROUND: Early detection and tracking of breast cancer treatment-related lymphedema have been helped by quantitative assessment methods and parameters, including bioelectrical impedance spectroscopy and tissue dielectric constant (TDC). Such measurements are evaluated with respect to interarm differences or ratios that (when exceeding specified thresholds) are suggestive of lymphedema. Specific threshold ratios depend on the assessment method and have been reported for arms. However, there is far less information available on thresholds to assess lymphedema that manifests in at-risk hands and essentially nothing known about TDC ratios in healthy hands...
June 4, 2018: Lymphatic Research and Biology
Anat Woldman, Nurit Kaneti, Eli Carmeli
BACKGROUND: Compression therapy is the only conservative treatment that has been shown to be effective for patients with lymphedema in randomized controlled trials. A commonly used classification system divides pressure into four categories ranging from mild to very strong. For lower limb edema, bandages with strong pressure were shown to be most effective. Recent studies indicate that many health care professionals use inadequate pressure. No study thus far has focused on therapists who are trained in lymphatic treatment...
June 4, 2018: Lymphatic Research and Biology
Stanley G Rockson
No abstract text is available yet for this article.
June 2018: Lymphatic Research and Biology
(no author information available yet)
No abstract text is available yet for this article.
June 2018: Lymphatic Research and Biology
Ahmed Mohammed Ismail, Said M Abdou, Amira Y Abdelnaby, Mennat Allah Hamdy, Ayman A El Saka, Amr Gawaly
BACKGROUND: Up till now, there is no satisfactory treatment for lymphedema. The aim of this study is to evaluate stem cell therapy in lymphedema. METHODS AND RESULTS: This prospective randomized study includes 40 patients with chronic lymphedema divided randomly into two groups: group I (stem cell therapy group) and group II (control group). In group I, bone marrow was aspirated and mononuclear cells were separated and then transplanted into the patients. In group II, patients compression therapy alone was applied...
June 2018: Lymphatic Research and Biology
Francine Blei
No abstract text is available yet for this article.
June 2018: Lymphatic Research and Biology
Hayahito Sakai, Yuma Fuse, Takumi Yamamoto
No abstract text is available yet for this article.
June 2018: Lymphatic Research and Biology
Joana M Mack, Gresham T Richter, Shelley E Crary
BACKGROUND: Slow-flow vascular malformations (VM) can be associated with localized intravascular coagulopathy (LIC) that is characterized by elevated D-Dimer levels and low fibrinogen and platelets. This can lead to bleeding and clotting tendencies, which can give rise to functional limitations such as pain and swelling and even progress to disseminated intravascular coagulopathy. METHODS AND RESULTS: We conducted a chart review of four patients with evidence of LIC who were started on rivaroxaban...
June 2018: Lymphatic Research and Biology
Pia Klernäs, Aina Johnsson, John Boyages, Håkan Brorson, Alex Munnoch, Karin Johansson
BACKGROUND: Lymphedema may affect patients' health-related quality of life (HRQoL) and thus a disease-specific questionnaire is needed. The Lymphedema Quality of life Inventory (LyQLI) has been tested for reliability and validity. The purpose of this study was to test the LyQLI for responsiveness and sensitivity. METHODS AND RESULTS: The study participants were patients with lymphedema in the upper or lower limb, attending a Swedish rehabilitation program (RP) and undergoing conservative treatment without surgery (RP-sample), or undergoing liposuction (LS) in Australia, Scotland, and Sweden (LS-sample)...
June 2018: Lymphatic Research and Biology
Ramazan Kizil, Banu Dilek, Ebru Şahin, Onur Engin, Ali Can Soylu, Elif Akalin, Serap Alper
BACKGROUND: In this randomized controlled study, we aimed to evaluate the effect of shoulder flexion exercise using continuous passive motion (CPM) on lymphedema during the treatment of breast cancer-related lymphedema (BCRL). METHODS: Thirty patients with BCRL were enrolled and completed the study. Fourteen patients were treated with complete decongestive therapy (CDT) and CPM in the intervention group, and 16 patients were treated with CDT alone (control group) for 15 sessions...
June 2018: Lymphatic Research and Biology
Katarzyna Ochalek, Tomasz Gradalski, Zbigniew Szygula, Hugo Partsch
BACKGROUND: After breast cancer surgery patients are at higher risk of lymphedema development and decreasing physical activity (PA), as well as decreasing health-related quality of life (HRQOL). The aim of the study was to compare the level of PA and HRQOL in women after breast cancer surgery using light arm compression with women not using compression 1 year after oncological treatment. METHODS AND RESULTS: Forty-five women were preoperatively randomly assigned to a compression group (CG, n = 23) or to no compression group (NCG, n = 22)...
June 2018: Lymphatic Research and Biology
Ana Paula Ferro, Vânia Tie Koga Ferreira, Monique Silva Rezende, Thamires Rodrigues de Souza, Ana Maria de Almeida, Rinaldo Roberto de Jesus Guirro, Elaine Caldeira de Oliveira Guirro
The objective of the study was to evaluate the intra- and inter-rater reliability of bioimpedance in determining upper limb volume in women with lymphedema resulting from breast cancer treatment, as well as its correlation with the upper limb volume calculated by circumferential measurement. A blind cross-sectional study was performed in which 27 women (62.59 ± 10.50 years) were evaluated with upper limb lymphedema secondary to breast cancer treatment. Two examiners performed assessments in the same volunteers independently and twice, with an interval of 1 week between assessments...
June 2018: Lymphatic Research and Biology
Janet Douglass, Patricia Graves, Susan Gordon
BACKGROUND: Expected values for tissue tonometry and bioimpedance spectroscopy (BIS) in the lower extremity of young people have not been established. These measures are commonly used to assess tissue changes in adult, breast cancer-related lymphedema of the arm. In tropical regions, identification of tissue changes in the lower limbs related to lymphatic filariasis is required; hence expected values and factors contributing to variation in tissue tonometry and BIS in two tropical populations were investigated...
June 2018: Lymphatic Research and Biology
Ke Li, Zheng Zhang, Ning Fei Liu, Parviz Sadigh, Verity Joyce Evans, Huihong Zhou, Weiqing Gao, Yi Xin Zhang
BACKGROUND: Fibrosis can enhance the exacerbation of lymphedema, which becomes obvious in late stage II-III lymphedema. However, whether far-infrared radiation thermotherapy (FIRT) can cure lymphedema fibrosis is still lack of research. This research was to investigate the therapeutic effect of FIRT on tissue fibrosis in the treatment of Late stage II-III lymphedema. METHODS: Patients accepted only FIRT for a total of 20 sessions. The treatment session duration was 2 hours, and a stable machine temperature of 42°C was maintained throughout treatments...
June 2018: Lymphatic Research and Biology
Cintia Furlan, Carolina Nascimben Matheus, Rodrigo Menezes Jales, Sophie Derchain, Luís Otávio Sarian
BACKGROUND: Surgical manipulations of the axilla may cause a condition known as Axillary Web Syndrome (AWS). The systems compromised and the sequence of events leading to this syndrome remains unknown. This study evaluated clinical, surgical, and vascular factors associated with onset and duration of AWS after breast cancer surgery. METHODS AND RESULTS: In this prospective study, 155 women were included. They were submitted to a physical examination that consisted of ultrasound Doppler of axillary and brachial vessels and the evaluation of AWS in 1, 3, and 6 months after breast cancer surgery...
June 2018: Lymphatic Research and Biology
Li Wang, Xiaoying Wu, Mingfeng Wu, Zizhou Zhao, Hui Tang, Suqin Li, Lianming Wu, Shiteng Suo, Qing Lu
BACKGROUND: Staging of lower extremity lymphedema (LEL) is difficult in clinical work. The excellent soft tissue contrast of magnetic resonance imaging (MRI) enables soft tissue changes to be feasibly and reproducibly characterized and distinguished. AIM: To determine whether cross-section areas of edema calves measured with MRI could be useful for staging of the LEL. MATERIALS AND METHODS: We recruited 138 participants who were clinically diagnosed with LEL: 61 unilateral and 77 bilateral LEL...
June 2018: Lymphatic Research and Biology
Elizabeth S Dylke, Helen Benincasa Nakagawa, Lanni Lin, Jillian L Clarke, Sharon L Kilbreath
BACKGROUND: Lymphedema of the breast, secondary to treatment for breast cancer, is difficult to assess due to the shape of the breast and the nature of the tissue. Ultrasound measurement of dermal thickness has been previously used to assess breast swelling; however, the reliability of the measurements, or what should be considered an abnormal thickness, is currently known. METHODS AND RESULTS: Thirty-eight women with breast edema were recruited and underwent assessment using ultrasound...
June 2018: Lymphatic Research and Biology
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