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Lymphatic Research and Biology

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https://www.readbyqxmd.com/read/29087786/strategies-for-avoiding-benzopyrone-hepatotoxicity-in-lymphedema-management-the-role-of-pharmacogenetics-metabolic-enzyme-gene-identification-and-patient-selection
#1
Minhao Hu, Neil B Piller
INTRODUCTION: Benzopyrones are plant-derived chemicals which have an evidenced degree of clinical efficacy in lymphedema management indicated in past trials. Unfortunately, in some of these cases idiosyncratic hepatotoxicity have been documented in a minority of patients. This review aims to tackle the problem of benzopyrone (particularly coumarin) toxicity by considering their metabolic pathways and identifying relevant alleles needed to take a targeted pharmacogenetic approach in its future use...
October 31, 2017: Lymphatic Research and Biology
https://www.readbyqxmd.com/read/29087773/local-echo-free-space-in-a-limb-with-lymphedema-represents-extracellular-fluid-in-the-entire-limb
#2
Kotaro Suehiro, Noriyasu Morikage, Koshiro Ueda, Makoto Samura, Yuriko Takeuchi, Takashi Nagase, Takahiro Mizoguchi, Kaori Nakamura, Kimikazu Hamano
BACKGROUND: We previously reported that local subcutaneous echo-free space (SEFS) in the leg was stirringly correlated with extracellular fluid (ECF) status in the same part of the leg when assessed using bioelectrical impedance analysis (BIA). In this study, we examined whether local SEFS represents the ECF status in the entire limb. METHODS AND RESULTS: In 51 legs and 40 arms with lymphedema (LE), subcutaneous tissue ultrasonography was performed to determine SEFS severity (range, 0-2)...
October 31, 2017: Lymphatic Research and Biology
https://www.readbyqxmd.com/read/29087763/donor-site-lymphedema-following-lymph-node-transfer-for-breast-cancer-related-lymphedema-a-systematic-review-of-the-literature
#3
Efterpi Demiri, Dimitrios Dionyssiou, Antonios Tsimponis, Olga Christina Goula, Panagiotis Mιlothridis, Leonidas Pavlidis, Georgia Alexandra Spyropoulou, Perikles Foroglou
Abstracts Background: Among current surgical options used for treating breast cancer-related lymphedema (BCRL), autologous lymph node transfer (ALNT) is shown to provide favorable results. However, postoperative donor-site lymphedema (DSL), following the lymphatic flap harvesting from the groin area, has already been reported. Our aim is to summarize the recent literature for evidence of DSL following an ALNT for BCRL. METHODS AND RESULTS: A PubMed bibliographic search was performed for published studies evaluating donor-site complications following LNT in BCRL patients...
October 31, 2017: Lymphatic Research and Biology
https://www.readbyqxmd.com/read/29077522/a-novel-uveolymphatic-drainage-pathway-possible-new-target-for-glaucoma-treatment
#4
Martyna Tomczyk-Socha, Anna Turno-Kręcicka
Glaucoma is a heterogeneous group of ophthalmic diseases leading to irreversible damage to the optic nerve. While the overall mechanism responsible for glaucoma remains obscure, the most important risk factor is elevated intraocular pressure. The current therapies, whether pharmacological or surgical, are primarily symptomatic with the aim to lower the intraocular pressure (IOP). Poorer response to treatment is associated, for example, with pseudoexfoliation glaucoma, which is determined by blocking the trabecular meshwork (TM) both by pigment grains and the pseudoexfoliation material...
October 27, 2017: Lymphatic Research and Biology
https://www.readbyqxmd.com/read/29072862/lymph-drainage-from-the-chylocyst-induced-hemodilution-in-an-in-vivo-rabbit-study
#5
Kumiko Ajima, Yoshiko Kawai, Daisuke Maejima, Shigeru Suzuki, Sachiho Yano, Moyuru Hayashi, Atsushi Katsumata, Maki Kaidoh, Yumiko Yokoyama, Toshio Ohhashi
To confirm our previous study that abdominal respiration has induced hemodilution in human subjects, we performed in-vivo experiments involving anesthetized rabbits. Fifteen 6- to 7-month-old male Japanese white rabbits were used in the animal experiments. Anesthesia was maintained with 2.5%-3.0% isoflurane under N2O + 100% O2 inhalation. Ventilation was maintained at 40 mL/breath for 20 breaths/min. Physiological saline solution was administered at rated 18 mL/h during the experiments. First, we attempted to evaluate lymph flow through the thoracic duct using Sonazoid-based contrast-enhanced ultrasound (CEUS)-guided method and then investigated the effects of manual lymph drainage of the chylocyst on the numbers of red blood cells (RBC), hematocrit (Ht) levels, and the blood concentrations of total protein (TP) and hemoglobin (Hb)...
October 26, 2017: Lymphatic Research and Biology
https://www.readbyqxmd.com/read/28961078/far-infrared-radiation-thermotherapy-improves-tissue-fibrosis-in-chronic-extremity-lymphedema
#6
Ke Li, Zheng Zhang, Ning Fei Liu, Parviz Sadigh, Verity Joyce Evans, Huihong Zhou, Weiqing Gao, Yi Xin Zhang
BACKGROUND: Fibrosis can enhance the exacerbation of lymphedema, which becomes obvious in late stage II-III lymphedema. However, whether far-infrared radiation thermotherapy (FIRT) can cure lymphedema fibrosis is still lack of research. This research was to investigate the therapeutic effect of FIRT on tissue fibrosis in the treatment of Late stage II-III lymphedema. METHODS: Patients accepted only FIRT for a total of 20 sessions. The treatment session duration was 2 hours, and a stable machine temperature of 42°C was maintained throughout treatments...
September 29, 2017: Lymphatic Research and Biology
https://www.readbyqxmd.com/read/28961075/indocyanine-green-lymphographic-and-lymphoscintigraphic-findings-in-genital-lymphedema-genital-pathway-score
#7
Hisako Hara, Makoto Mihara
BACKGROUND: Although genital lymphedema is a challenging disease, its mechanism is unclear. The aim of this study was to identify the lymphatic flow in genital lymphedema and establish a suitable examination for genital lymphedema. METHODS: We injected phytic acid or albumin labeled with (99m)Tc at the bilateral first web spaces of the feet of 47 patients for lymphoscintigraphy. For indocyanine green (ICG) lymphography, we injected ICG into the first web spaces of both feet and other points if necessary...
September 29, 2017: Lymphatic Research and Biology
https://www.readbyqxmd.com/read/28961070/vascular-alterations-in-axillary-and-brachial-vessels-in-patients-with-axillary-web-syndrome-after-breast-cancer-surgery
#8
Cintia Furlan, Carolina Nascimben Matheus, Rodrigo Menezes Jales, Sophie Derchain, Luís Otávio Sarian
BACKGROUND: Surgical manipulations of the axilla may cause a condition known as Axillary Web Syndrome (AWS). The systems compromised and the sequence of events leading to this syndrome remains unknown. This study evaluated clinical, surgical, and vascular factors associated with onset and duration of AWS after breast cancer surgery. METHODS AND RESULTS: In this prospective study, 155 women were included. They were submitted to a physical examination that consisted of ultrasound Doppler of axillary and brachial vessels and the evaluation of AWS in 1, 3, and 6 months after breast cancer surgery...
September 29, 2017: Lymphatic Research and Biology
https://www.readbyqxmd.com/read/28956970/lymphedema-leads-to-fat-deposition-in-muscle-and-decreased-muscle-water-volume-after-liposuction-a-magnetic-resonance-imaging-study
#9
Mattias Hoffner, Pernilla Peterson, Sven Månsson, Håkan Brorson
BACKGROUND: Lymphedema leads to adipose tissue deposition. Water-fat magnetic resonance imaging (MRI) can quantify and localize fat and water. The presence of excess fat and excess water/muscle in the subfascial compartment of the lymphedematous limb has not been investigated before. The aim of this study was to investigate epifascial and subfascial fat and water contents in patients with chronic lymphedema before and after liposuction. METHODS AND RESULTS: Seven patients with arm lymphedema and six with leg lymphedema were operated on...
September 28, 2017: Lymphatic Research and Biology
https://www.readbyqxmd.com/read/28956956/edema-areas-of-calves-measured-with-magnetic-resonance-imaging-as-a-novel-indicator-for-early-staging-of-lower-extremity-lymphedema
#10
Li Wang, Xiaoying Wu, Mingfeng Wu, Zizhou Zhao, Hui Tang, Suqin Li, Lianming Wu, Shiteng Suo, Qing Lu
BACKGROUND: Staging of lower extremity lymphedema (LEL) is difficult in clinical work. The excellent soft tissue contrast of magnetic resonance imaging (MRI) enables soft tissue changes to be feasibly and reproducibly characterized and distinguished. AIM: To determine whether cross-section areas of edema calves measured with MRI could be useful for staging of the LEL. MATERIALS AND METHODS: We recruited 138 participants who were clinically diagnosed with LEL: 61 unilateral and 77 bilateral LEL...
September 28, 2017: Lymphatic Research and Biology
https://www.readbyqxmd.com/read/28956715/measuring-limb-volume-accuracy-and-reliability-of-tape-measurement-versus-perometer-measurement
#11
Amy R Sharkey, Samuel W King, Rachel Y Kuo, Shixin B Bickerton, Alexander J Ramsden, Dominic Furniss
BACKGROUND: Accurate limb volume measurement is key in the assessment of outcomes in lymphedema microsurgery. There are two commonly used methods as follows: manual circumferential measurement (tape) or Perometer measurement. There are no data on the intra- and interclass correlation of either method, making it difficult to establish a gold standard of limb volume measurement. We aim to assess the intra- and interclass correlation of each method to establish the most appropriate method for clinical practice and future research studies, aiming to compare the accuracy and reliability of tape measurement as assessed against Perometer measurement...
September 28, 2017: Lymphatic Research and Biology
https://www.readbyqxmd.com/read/28956701/segmental-bioimpedance-informs-diagnosis-of-breast-cancer-related-lymphedema
#12
Brenda J Svensson, Elizabeth S Dylke, Leigh C Ward, Sharon L Kilbreath
BACKGROUND: Detection of lymphedema, particularly its mild stage, is clinically challenging. The aim of this study was to determine whether segmental bioimpedance spectroscopy (BIS) provided additional information to whole arm BIS in assessing women with or at risk of lymphedema following breast cancer. METHODS AND RESULTS: Participants (n = 66), aged 61.6 ± 10.5 years (mean ± standard deviation [SD]), were grouped according to lymphedema status: (1) at-risk (n = 24) had no indicators of lymphedema and (2) lymphedema (n = 42) were suspected to be developing lymphedema or had previously met lymphedema diagnostic criteria and undergone treatment...
September 28, 2017: Lymphatic Research and Biology
https://www.readbyqxmd.com/read/28956696/alteration-of-blood-circulation-in-the-upper-limb-before-and-after-surgery-for-breast-cancer-associated-with-axillary-lymph-node-dissection-or-sentinel-lymph-node-biopsy
#13
Maíta M O L L Vaz, Rinaldo Roberto de Jesus Guirro, Hélio Humberto Angotti Carrara, Thais Montezuma, Carla Silva Perez, Elaine Caldeira de Oliveira Guirro
BACKGROUND: This aim of this study was to assess and compare arterial and venous circulation in women with axillary lymph node dissection (ALND) and sentinel lymph node biopsy (SLNB) before and after breast cancer surgery. METHODS AND RESULTS: Fifty-two women took part in the study, divided into three groups: those undergoing ALND at levels I, II, and III (ALNDG), with mean age of 56.29 ± 10.85 years old; those undergoing sentinel lymph node biopsy (SLNBG), with mean age of 57...
September 28, 2017: Lymphatic Research and Biology
https://www.readbyqxmd.com/read/28956689/lymphatic-reconnection-and-restoration-of-lymphatic-flow-by-nonvascularized-lymph-node-transplantation-real-time-fluorescence-imaging-using-indocyanine-green-and-fluorescein-isothiocyanate-dextran
#14
Taku Maeda, Yuhei Yamamoto, Daisuke Iwasaki, Toshihiko Hayashi, Emi Funayama, Akihiko Oyama, Naoki Murao, Hiroshi Furukawa
BACKGROUND: Lymph node transplantation is being increasingly recognized as a method of reconstruction of the lymphatic system for the treatment of lymphedema. However, the mechanisms regulating the connections between the lymphatic vessels and the lymph nodes remain poorly understood. The objective of this study was to examine whether removal of a popliteal lymph node (PLN) could result in rerouting of lymph flow and whether a single transplanted nonvascularized lymph node could reconnect with a lymphatic vessel and restore lymph flow...
September 28, 2017: Lymphatic Research and Biology
https://www.readbyqxmd.com/read/28937924/update-september-2017
#15
Francine Blei
No abstract text is available yet for this article.
September 2017: Lymphatic Research and Biology
https://www.readbyqxmd.com/read/28937923/psychological-factors-in-chronic-edema-a-case-control-study
#16
Christine J Moffatt, Aimee Aubeeluck, Peter J Franks, Debra C Doherty, Peter Mortimer, Isabelle Quere
BACKGROUND: To examine psychological health and perceived social support in patients with chronic edema (CE). METHODS AND RESULTS: A random sample of 107 patients with CE was group matched for age and gender with 102 community controls. The cases had swelling of the arm (38%) and leg (61%) and midline swelling (14%). Cases were more likely to be single or divorced/separated (p = 0.041) and have reduced mobility (p < 0.001). They had significantly poorer overall health related quality of life (HRQoL), in particular physical functioning (p = 0...
September 2017: Lymphatic Research and Biology
https://www.readbyqxmd.com/read/28937922/a-role-for-near-infrared-fluorescent-imaging-in-the-evaluation-of-lymphatic-function
#17
Stanley G Rockson
No abstract text is available yet for this article.
September 2017: Lymphatic Research and Biology
https://www.readbyqxmd.com/read/28885862/volume-and-tissue-composition-changes-measured-with-dual-energy-x-ray-absorptiometry-in-melanoma-related-limb-lymphedema
#18
Caroline A Gjorup, Helle W Hendel, Bo Zerahn, Karin Dahlstroem, Krzysztof T Drzewiecki, Tobias W Klausen, Lisbet Rosenkrantz Hölmich
Abstracts Background: The aim of this cross-sectional study was to investigate the volume, fat mass, and lean mass in both upper and lower limbs measured with dual-energy X-ray absorptiometry (DXA) in melanoma patients with melanoma-related limb lymphedema. METHODS AND RESULTS: Four hundred thirty-one patients who had undergone surgical treatment with wide local excision and unilateral axillary or inguinal sentinel lymph node biopsy and/or complete lymph node dissection participated in a survey, and they underwent clinical examination and measurements of their upper or lower limbs with DXA...
September 2017: Lymphatic Research and Biology
https://www.readbyqxmd.com/read/28880750/effects-of-aqua-lymphatic-therapy-on-lower-extremity-lymphedema-a-randomized-controlled-study
#19
Gulbin Ergin, Didem Karadibak, Hulya Ozlem Sener, Baris Gurpinar
BACKGROUND: The purpose of this study is to investigate the effects of the aqua-lymphatic therapy (ALT) on unilateral lower extremity lymphedema in the maintenance phase. MATERIALS AND METHODS: This is a randomized controlled trial with a blinded assessor. The study was completed with 30 ALT and 27 control group participants. Foot volume was assessed by a water displacement device, limb volume by circumference measurements, functional capacity by a 6-minute walk test, quality of life by Short Form-36, and social appearance by Social Appearance Anxiety Scale and hopeless by Beck Hopeless Scale...
September 2017: Lymphatic Research and Biology
https://www.readbyqxmd.com/read/28880734/precautionary-behaviors-and-breast-cancer-related-lymphedema
#20
Cheryl Brunelle, Meyha Swaroop, Maria Asdourian, Melissa Skolny, Hoda Sayegh, Alphonse G Taghian
No abstract text is available yet for this article.
September 2017: Lymphatic Research and Biology
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