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Lymphatic Research and Biology

Zeynep Erdogan Iyigun, Filiz Agacayak, Ahmet Serkan Ilgun, Filiz Elbuken Celebi, Cetin Ordu, Gul Alco, Alper Ozturk, Tomris Duymaz, Fatma Aktepe, Vahit Ozmen
BACKGROUND: Early detection of lymphedema gives an opportunity for effective and successful treatment of lymphedema. However, the current diagnosis methods, except the bioimpedance analysis, perometry, and indocyanine green lymphography, have limitations in detecting early stage lymphedema. Sonoelastography is a diagnostic ultrasound technique that provides an opportunity to estimate soft tissue stiffness. Shear wave elastography (SWE) is a brand new elastography technique. Unlike strain elastography, this method is conducted automatically, that is, independently of user's manual tissue compression...
September 13, 2018: Lymphatic Research and Biology
Frank Vicini, Chirag Shah, Pat Whitworth, Michael Walker, Jing Shi
BACKGROUND: We reviewed serial bioimpedance measurements in order to quantify the relationship between changes in these scores and a patient's risk for developing breast cancer-related lymphedema (BCRL). METHODS AND RESULTS: From April 2010 through November 2016, 505 patients were prospectively evaluated using bioimpedance spectroscopy (BIS/L-Dex). Patients received preoperative and postoperative L-Dex measurements and were categorized based upon risk for BCRL with respect to axillary staging procedure, radiation use, taxane use, and body mass index (BMI)...
August 22, 2018: Lymphatic Research and Biology
Sheila H Ridner, Mary S Dietrich, Kandace Spotanski, Jennifer K Doersam, Michael S Cowher, Bret Taback, Sarah McLaughlin, Nicolas Ajkay, John Boyages, Louise Koelmeyer, Sarah DeSnyder, Chirag Shah, Frank Vicini
BACKGROUND: Data regarding pretreatment, bioimpedance spectroscopy (BIS) L-Dex® values for patients newly diagnosed with breast cancer, and longitudinal data 12 months postoperatively are lacking. This study describes L-Dex values at the time of breast cancer diagnosis and maximum L-Dex change within 12 months of surgery. METHODS AND RESULTS: Patients were enrolled in a parent, clinical trial that compares the effectiveness of BIS for early detection of breast cancer-related lymphedema to tape measurement...
August 21, 2018: Lymphatic Research and Biology
Emma Cousins, Viviana Cintolesi, Laurence Vass, Anthony W B Stanton, Andrew Irwin, Susan D Heenan, Peter S Mortimer
BACKGROUND: Yellow nail syndrome (YNS) is a rare disease manifesting as a triad of yellow-green dystrophic nails, lymphedema, and chronic respiratory disease. The etiology of YNS is obscure and investigations are few. A single lymphatic pathogenesis has been proposed to account for all the associated features, and despite the lack of evidence for a unifying lymphatic mechanism, this hypothesis prevails. The objective was to explore the lymphatic phenotype in YNS and to establish whether lymphatic dysfunction could be a major contributing factor to the disease process...
August 2018: Lymphatic Research and Biology
Tessa De Vrieze, Nick Gebruers, Nele Devoogdt
No abstract text is available yet for this article.
August 2018: Lymphatic Research and Biology
Waldemar L Olszewski, Marzanna T Zaleska
No abstract text is available yet for this article.
August 2018: Lymphatic Research and Biology
Horacio Gomez-Acevedo, James R Dornhoffer, Annjanette Stone, Yuemeng Dai, Gresham T Richter
Lymphatic malformations (LMs) are congenital vascular anomalies characterized by dilated and cystic lymphatic channels. They are subdivided into macrocystic and microcystic lesions based upon the predominant size of the cysts involved. However, significant differences in clinical characteristics, treatment outcomes, and prognosis between macrocytic and microcytic disease suggest variation in underlying biologic and genetic influences. Indirect differential expression analysis revealed that 426 genes are significantly different (p < 0...
August 2018: Lymphatic Research and Biology
Francine Blei
No abstract text is available yet for this article.
August 2018: Lymphatic Research and Biology
Stanley G Rockson
No abstract text is available yet for this article.
August 2018: Lymphatic Research and Biology
Susanne Wiegand, Gunnar Wichmann, Andreas Dietz
BACKGROUND: Extensive lymphatic malformations are low-flow vascular malformations that can cause devastating complications. Treatment of these malformations is challenging. This systematic review presents current use of sirolimus in patients with extensive lymphatic malformations. METHODS: MEDLINE and Google scholar search was conducted for studies on sirolimus treatment of lymphatic malformations up to July 2017. Search items included "lymphatic malformation," "lymphangioma," "cystic hygroma," "vascular malformation," "low-flow malformation," "sirolimus," "rapamycin," and "mTOR inhibitor...
August 2018: Lymphatic Research and Biology
Megumi Kishimoto, Masaya Akashi, Yasumasa Kakei, Junya Kusumoto, Akiko Sakakibara, Takumi Hasegawa, Shungo Furudoi, Ryohei Sasaki, Takahide Komori
BACKGROUND: A problematic complication after radiation therapy is lymphedema. Development of lymphedema is associated with an increase in lymphatic paracellular permeability. The current study investigated the effects of radiation on intercellular junctions and paracellular permeability in cultured human dermal lymphatic endothelial cells (HDLECs). METHODS AND RESULTS: Double immunofluorescence staining with vascular endothelial (VE)-cadherin and actin immediately after X-ray irradiation (5 or 20 Gy) was performed...
August 2018: Lymphatic Research and Biology
Kotaro Suehiro, Noriyasu Morikage, Koshiro Ueda, Makoto Samura, Yuriko Takeuchi, Takashi Nagase, Takahiro Mizoguchi, Kaori Nakamura, Kimikazu Hamano
BACKGROUND: To clarify the differences in the mode of fluid accumulation between arm and leg lymphedema using bioelectrical impedance analysis (BIA). METHODS AND RESULTS: In 22 arms with lymphedema (ALE) and 65 legs with lymphedema (LLE), as well as 54 legs with venous edema (VE) for comparison, BIA was performed twice between April 2015 and March 2017. Then, the changes in BIA-derived parameters were correlated with the changes in extremity volumes. In ALE, the change in extracellular fluid resistance (Re) was negatively correlated with the change in arm volume (r = 0...
August 2018: Lymphatic Research and Biology
Svend Hvidsten, Navid M Toyserkani, Jens A Sørensen, Poul F Høilund-Carlsen, Jane A Simonsen
BACKGROUND: Lymphoscintigraphy is commonly used to assess breast cancer-related lymphedema. However, a reliable quantitative method that clearly distinguishes normal lymphatic function from lymphedema is desired. We propose a quantitative method based upon the physiological mean transit time (MTT) measure of lymph fluid passing through the arm. METHODS AND RESULTS: Eleven patients, aged 34-68 years, with unilateral arm lymphedema following breast cancer treatment underwent simultaneous bilateral lymphoscintigraphy using intradermal injection of 99m Tc-labeled human serum albumin (HSA)...
August 2018: Lymphatic Research and Biology
Makoto Mihara, Hisako Hara, Yoshihisa Kawakami, Han Peng Zhou, Shuichi Tange, Kazuki Kikuchi, Takuya Iida
BACKGROUND: Histological changes in the collecting lymphatics in patients with lymphedema are classified as Normal type, Ectasis type, Contraction type, and Sclerosis type (NECST) classification. In this study, we investigated the condition of the lymphatic vessels in different sites of the legs. PATIENTS AND METHODS: We prospectively investigated the lymphatic vessels of patients with lymphedema who underwent lymphaticovenous anastomosis (LVA) from August 8, 2014 to August 4, 2015 based on the NECST classification...
August 2018: Lymphatic Research and Biology
Eun Joo Yang, Seoung Yeon Kim, Woo Hyung Lee, Jae-Young Lim, Jaebong Lee
BACKGROUND: If we use only volumetry for measuring lymphedema, we could underdiagnose lymphedema with characteristics of biomechanical changes without definite volume change, especially in the medial forearm. METHODS AND RESULTS: In total, 158 breast cancer patients participated in this study. Arm volume was measured by water displacement volumetry, and segmental volumes were calculated from circumferences by using the truncated cone method. Subcutaneous ultrasound echogenicities were assessed on the medial side of the upper arm and forearm of both arms and graded by subcutaneous echogenicity grade (SEG) and revised SEG (rSEG)...
August 2018: Lymphatic Research and Biology
Ruben Buendia, Tim Essex, Sharon L Kilbreath, Sharon Czerniec, Elizabeth Dylke, Leigh C Ward
BACKGROUND: Breast cancer-related lymphedema (BCRL) is a chronic condition characterized by accumulation of lymph fluid that may subsequently become fibrotic with infiltration of adipose tissue. Bioimpedance spectroscopy (BIS) is the preferred method for early detection of lymphedema as it can estimate extracellular lymph fluid. This study developed a modified impedance technique that concurrently estimates both lymph accumulation and increases in adipose tissue. METHODS AND RESULTS: BIS was used to estimate the adipose tissue volume in a cohort of healthy women (n = 171), which was found to be highly correlated (r > 0...
August 2018: Lymphatic Research and Biology
Jin A Yoon, Yong Beom Shin, Myung Jun Shin, Ra Yu Yun, Keun Young Kim, You Sun Song, Youngtae Bae, Seokwon Lee, Younglae Jung, Sang Hyun Lee
BACKGROUND: Obesity is one of the well-known initiating and aggravating factors of lymphedema. Body mass index (BMI) is typically used to define obesity, but in Asian populations, health risks are elevated at lower BMI levels, and abdominal fat may be a better obesity metric. Thus, we assessed the potential association between abdominal obesity and lymphedema severity in postoperative breast cancer patients. METHODS AND RESULTS: Thirty-three women with breast cancer-related lymphedema participated in this study...
June 5, 2018: Lymphatic Research and Biology
Harvey N Mayrovitz, Evelina Arzanova, Scarlett Somarriba, Samar Eisa
BACKGROUND: Early detection and tracking of breast cancer treatment-related lymphedema have been helped by quantitative assessment methods and parameters, including bioelectrical impedance spectroscopy and tissue dielectric constant (TDC). Such measurements are evaluated with respect to interarm differences or ratios that (when exceeding specified thresholds) are suggestive of lymphedema. Specific threshold ratios depend on the assessment method and have been reported for arms. However, there is far less information available on thresholds to assess lymphedema that manifests in at-risk hands and essentially nothing known about TDC ratios in healthy hands...
June 4, 2018: Lymphatic Research and Biology
Anat Woldman, Nurit Kaneti, Eli Carmeli
BACKGROUND: Compression therapy is the only conservative treatment that has been shown to be effective for patients with lymphedema in randomized controlled trials. A commonly used classification system divides pressure into four categories ranging from mild to very strong. For lower limb edema, bandages with strong pressure were shown to be most effective. Recent studies indicate that many health care professionals use inadequate pressure. No study thus far has focused on therapists who are trained in lymphatic treatment...
June 4, 2018: Lymphatic Research and Biology
Stanley G Rockson
No abstract text is available yet for this article.
June 2018: Lymphatic Research and Biology
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