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Lymphatic Research and Biology

Svend Hvidsten, Navid M Toyserkani, Jens A Sørensen, Poul F Høilund-Carlsen, Jane A Simonsen
BACKGROUND: Lymphoscintigraphy is commonly used to assess breast cancer-related lymphedema. However, a reliable quantitative method that clearly distinguishes normal lymphatic function from lymphedema is desired. We propose a quantitative method based upon the physiological mean transit time (MTT) measure of lymph fluid passing through the arm. METHODS AND RESULTS: Eleven patients, aged 34-68 years, with unilateral arm lymphedema following breast cancer treatment underwent simultaneous bilateral lymphoscintigraphy using intradermal injection of 99mTc-labeled human serum albumin (HSA)...
January 18, 2018: Lymphatic Research and Biology
Kathryn Glaser, Peter Dickie, Derek Neilson, Alexander Osborn, Belinda Hsi Dickie
BACKGROUND: Lymphatic endothelial cells (LECs) derived from lymphatic malformations (LMs) bear activated PIK3CA alleles yet display an inflammatory gene expression profile. A basis for the inflammatory phenotype was sought by screening for coexisting somatic mutations. METHODS AND RESULTS: Fourteen independent LEC populations bearing activated PIK3CA alleles were isolated from LM. These were characterized by the expression of growth and inflammatory genes (VEGFC, IL-6, COX-2, IL-8, HO-1, E-SEL) by qRT-PCR...
January 18, 2018: Lymphatic Research and Biology
Angelika Chachaj, Bartosz Puła, Mariusz Chabowski, Jędrzej Grzegrzółka, Ewa Szahidewicz-Krupska, Maciej Karczewski, Dariusz Janczak, Piotr Dzięgiel, Marzenna Podhorska-Okołów, Grzegorz Mazur, Andrzej Gamian, Andrzej Szuba
BACKGROUND: Recent studies, mainly on animal models, have suggested that negatively charged glycosaminoglycans, macrophages, and lymph vessels in the skin interstitium may serve as extrarenal control of sodium balance and blood pressure. The aim of the study was to prove the hypothesis that skin interstitium has a role in the pathogenesis of hypertension in humans. METHODS AND RESULTS: We have examined skin biopsies in 91 patients from the department of surgery who had elective surgery with abdominal skin incision: 43 were hypertensive, 14 had resistant hypertension, and 34 with normal blood pressure as control group (median patients' age in these groups estimated accordingly 64 vs...
January 18, 2018: Lymphatic Research and Biology
Ramazan Kizil, Banu Dilek, Ebru Şahin, Onur Engin, Ali Can Soylu, Elif Akalin, Serap Alper
BACKGROUND: In this randomized controlled study, we aimed to evaluate the effect of shoulder flexion exercise using continuous passive motion (CPM) on lymphedema during the treatment of breast cancer-related lymphedema (BCRL). METHODS: Thirty patients with BCRL were enrolled and completed the study. Fourteen patients were treated with complete decongestive therapy (CDT) and CPM in the intervention group, and 16 patients were treated with CDT alone (control group) for 15 sessions...
January 17, 2018: Lymphatic Research and Biology
Makoto Mihara, Hisako Hara, Yoshihisa Kawakami, Han Peng Zhou, Shuichi Tange, Kazuki Kikuchi, Takuya Iida
BACKGROUND: Histological changes in the collecting lymphatics in patients with lymphedema are classified as Normal type, Ectasis type, Contraction type, and Sclerosis type (NECST) classification. In this study, we investigated the condition of the lymphatic vessels in different sites of the legs. PATIENTS AND METHODS: We prospectively investigated the lymphatic vessels of patients with lymphedema who underwent lymphaticovenous anastomosis (LVA) from August 8, 2014 to August 4, 2015 based on the NECST classification...
January 17, 2018: Lymphatic Research and Biology
Eun Joo Yang, Seoung Yeon Kim, Woo Hyung Lee, Jae-Young Lim, Jaebong Lee
BACKGROUND: If we use only volumetry for measuring lymphedema, we could underdiagnose lymphedema with characteristics of biomechanical changes without definite volume change, especially in the medial forearm. METHODS AND RESULTS: In total, 158 breast cancer patients participated in this study. Arm volume was measured by water displacement volumetry, and segmental volumes were calculated from circumferences by using the truncated cone method. Subcutaneous ultrasound echogenicities were assessed on the medial side of the upper arm and forearm of both arms and graded by subcutaneous echogenicity grade (SEG) and revised SEG (rSEG)...
January 17, 2018: Lymphatic Research and Biology
Ruben Buendia, Tim Essex, Sharon L Kilbreath, Sharon Czerniec, Elizabeth Dylke, Leigh C Ward
BACKGROUND: Breast cancer-related lymphedema (BCRL) is a chronic condition characterized by accumulation of lymph fluid that may subsequently become fibrotic with infiltration of adipose tissue. Bioimpedance spectroscopy (BIS) is the preferred method for early detection of lymphedema as it can estimate extracellular lymph fluid. This study developed a modified impedance technique that concurrently estimates both lymph accumulation and increases in adipose tissue. METHODS AND RESULTS: BIS was used to estimate the adipose tissue volume in a cohort of healthy women (n = 171), which was found to be highly correlated (r > 0...
December 18, 2017: Lymphatic Research and Biology
Katarzyna Ochalek, Tomasz Gradalski, Zbigniew Szygula, Hugo Partsch
BACKGROUND: After breast cancer surgery patients are at higher risk of lymphedema development and decreasing physical activity (PA), as well as decreasing health-related quality of life (HRQOL). The aim of the study was to compare the level of PA and HRQOL in women after breast cancer surgery using light arm compression with women not using compression 1 year after oncological treatment. METHODS AND RESULTS: Forty-five women were preoperatively randomly assigned to a compression group (CG, n = 23) or to no compression group (NCG, n = 22)...
December 18, 2017: Lymphatic Research and Biology
Ana Paula Ferro, Vânia Tie Koga Ferreira, Monique Silva Rezende, Thamires Rodrigues de Souza, Ana Maria de Almeida, Rinaldo Roberto de Jesus Guirro, Elaine Caldeira de Oliveira Guirro
The objective of the study was to evaluate the intra- and inter-rater reliability of bioimpedance in determining upper limb volume in women with lymphedema resulting from breast cancer treatment, as well as its correlation with the upper limb volume calculated by circumferential measurement. A blind cross-sectional study was performed in which 27 women (62.59 ± 10.50 years) were evaluated with upper limb lymphedema secondary to breast cancer treatment. Two examiners performed assessments in the same volunteers independently and twice, with an interval of 1 week between assessments...
December 18, 2017: Lymphatic Research and Biology
Janet Douglass, Patricia Graves, Susan Gordon
BACKGROUND: Expected values for tissue tonometry and bioimpedance spectroscopy (BIS) in the lower extremity of young people have not been established. These measures are commonly used to assess tissue changes in adult, breast cancer-related lymphedema of the arm. In tropical regions, identification of tissue changes in the lower limbs related to lymphatic filariasis is required; hence expected values and factors contributing to variation in tissue tonometry and BIS in two tropical populations were investigated...
December 11, 2017: Lymphatic Research and Biology
Minhao Hu, Neil B Piller
INTRODUCTION: Benzopyrones are plant-derived chemicals which have an evidenced degree of clinical efficacy in lymphedema management indicated in past trials. Unfortunately, in some of these cases idiosyncratic hepatotoxicity have been documented in a minority of patients. This review aims to tackle the problem of benzopyrone (particularly coumarin) toxicity by considering their metabolic pathways and identifying relevant alleles needed to take a targeted pharmacogenetic approach in its future use...
October 31, 2017: Lymphatic Research and Biology
Kotaro Suehiro, Noriyasu Morikage, Koshiro Ueda, Makoto Samura, Yuriko Takeuchi, Takashi Nagase, Takahiro Mizoguchi, Kaori Nakamura, Kimikazu Hamano
BACKGROUND: We previously reported that local subcutaneous echo-free space (SEFS) in the leg was stirringly correlated with extracellular fluid (ECF) status in the same part of the leg when assessed using bioelectrical impedance analysis (BIA). In this study, we examined whether local SEFS represents the ECF status in the entire limb. METHODS AND RESULTS: In 51 legs and 40 arms with lymphedema (LE), subcutaneous tissue ultrasonography was performed to determine SEFS severity (range, 0-2)...
October 31, 2017: Lymphatic Research and Biology
Efterpi Demiri, Dimitrios Dionyssiou, Antonios Tsimponis, Olga Christina Goula, Panagiotis Mιlothridis, Leonidas Pavlidis, Georgia Alexandra Spyropoulou, Perikles Foroglou
Abstracts Background: Among current surgical options used for treating breast cancer-related lymphedema (BCRL), autologous lymph node transfer (ALNT) is shown to provide favorable results. However, postoperative donor-site lymphedema (DSL), following the lymphatic flap harvesting from the groin area, has already been reported. Our aim is to summarize the recent literature for evidence of DSL following an ALNT for BCRL. METHODS AND RESULTS: A PubMed bibliographic search was performed for published studies evaluating donor-site complications following LNT in BCRL patients...
October 31, 2017: Lymphatic Research and Biology
Kumiko Ajima, Yoshiko Kawai, Daisuke Maejima, Shigeru Suzuki, Sachiho Yano, Moyuru Hayashi, Atsushi Katsumata, Maki Kaidoh, Yumiko Yokoyama, Toshio Ohhashi
To confirm our previous study that abdominal respiration has induced hemodilution in human subjects, we performed in-vivo experiments involving anesthetized rabbits. Fifteen 6- to 7-month-old male Japanese white rabbits were used in the animal experiments. Anesthesia was maintained with 2.5%-3.0% isoflurane under N2O + 100% O2 inhalation. Ventilation was maintained at 40 mL/breath for 20 breaths/min. Physiological saline solution was administered at rated 18 mL/h during the experiments. First, we attempted to evaluate lymph flow through the thoracic duct using Sonazoid-based contrast-enhanced ultrasound (CEUS)-guided method and then investigated the effects of manual lymph drainage of the chylocyst on the numbers of red blood cells (RBC), hematocrit (Ht) levels, and the blood concentrations of total protein (TP) and hemoglobin (Hb)...
October 26, 2017: Lymphatic Research and Biology
Scott D Zawieja, Jorge A Castorena-Gonzalez, Brandon Dixon, Michael J Davis
Recent years have seen a renewed interest in studies of the lymphatic system. This review addresses the differences between in vivo and ex vivo methods for visualization and functional studies of lymphatic networks, with an emphasis on studies of collecting lymphatic vessels. We begin with a brief summary of the historical uses of both approaches. For the purpose of detailed comparisons, we subdivide in vivo methods into those visualizing lymphatic networks through the intact skin and those using surgically opened skin...
December 2017: Lymphatic Research and Biology
Francine Blei
No abstract text is available yet for this article.
December 2017: Lymphatic Research and Biology
Sandrine Mestre, Gessy Gaillard, Murielle Benhamou, Virginie Soulier-Sotto, Monira Nou, Marion Pasqualini, Cyrine Ben Amor, Isabelle Quere
BACKGROUND: Lymphedema of the arm and/or hand is a well-established complication of breast cancer therapy. The objective of the study was to determine the interest of auto-adjustable MOBIDERM® Autofit night arm sleeve in controlling edema rebound effect in breast cancer-related lymphedema patients just after a successful intensive phase of decongestive lymphedema therapy (DLT). MATERIALS AND METHODS: This is a subgroup analysis of MARILYN Study, conducted on 40 patients after completion of intensive DLT...
December 2017: Lymphatic Research and Biology
Olga Yu Gasheva, Jerome P Trzeciakowski, Anatoliy A Gashev, David C Zawieja
BACKGROUND: The initial periods of increased flow inside lymphatic vessels demonstrate specific temporary patterns of self-tuning of lymphatic vessel contractility that are heterogeneous across regional lymphatic networks. The current literature primarily refers to the immediate and fast reactions of the lymphangions to increases in basal flow. Until now, there were no available data on how the lymphatic vessels react to comparatively longer periods of imposed flow. METHODS AND RESULTS: In this study, we measured and analyzed the contractility of the rat thoracic duct segments, isolated, cannulated, and pressurized at 3 cm H2O at no imposed flow conditions and during 4 hours of imposed flow (constant transaxial pressure gradient of 2 cm H2O)...
December 2017: Lymphatic Research and Biology
Stanley G Rockson
No abstract text is available yet for this article.
December 2017: Lymphatic Research and Biology
Martyna Tomczyk-Socha, Anna Turno-Kręcicka
Glaucoma is a heterogeneous group of ophthalmic diseases leading to irreversible damage to the optic nerve. While the overall mechanism responsible for glaucoma remains obscure, the most important risk factor is elevated intraocular pressure. The current therapies, whether pharmacological or surgical, are primarily symptomatic with the aim to lower the intraocular pressure (IOP). Poorer response to treatment is associated, for example, with pseudoexfoliation glaucoma, which is determined by blocking the trabecular meshwork (TM) both by pigment grains and the pseudoexfoliation material...
December 2017: Lymphatic Research and Biology
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