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Eye & Contact Lens

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https://www.readbyqxmd.com/read/28799960/critical-contact-lens-oxygen-transmissibility-and-tear-lens-oxygen-tension-to-preclude-corneal-neovascularization
#1
Karen K Yeung, Helen J Yang, Andrew L Nguyen, Barry A Weissman
OBJECTIVE: The purpose of this study is to determine the peripheral oxygen transmissibility (pDk/t) and respective central oxygen transmissibility (cDk/t) in soft contact lenses (SCLs) which might preclude SCL-driven corneal neovascularization (NV) in healthy myopic SCL users. METHODS: Twenty subjectively successful SCL-wearing patients who presented with asymptomatic but active peripheral corneal NV (not ghost vessels) were recruited as study patients. Twenty-one patients who did not have NV were similarly recruited as controls...
August 9, 2017: Eye & Contact Lens
https://www.readbyqxmd.com/read/28737665/refractive-and-corneal-aberrometric-changes-after-crescentic-lamellar-wedge-resection-in-pellucid-marginal-degeneration
#2
Selim Genç, Hanefi Çakır, Emre Güler, Ümit Çallı
OBJECTIVE: To evaluate the effectiveness of crescentic corneal lamellar wedge resection for the treatment of pellucid marginal degeneration (PMD) in improving refractive, visual, and corneal aberrometry. METHODS: The study included 10 eyes of 10 patients who had undergone corneal lamellar wedge resection for PMD. Pellucid marginal degeneration was diagnosed based on the clinical signs and corneal topography. The corneal aberrometry was evaluated with Sirius corneal topography...
July 21, 2017: Eye & Contact Lens
https://www.readbyqxmd.com/read/28737664/smap3d-corneo-scleral-topographer-repeatability-in-scleral-lens-patients
#3
Gregory DeNaeyer, Donald R Sanders
OBJECTIVES: To determine repeatability of measurements using the sMap3D Corneo-Scleral Topographer in patients presenting for scleral lens fitting. METHODS: As part of our standard clinical evaluation, 25 eyes of 23 patients who presented for scleral lens fitting were examined twice in the same day with the sMap3D in this retrospective study. Sagittal height (SAG), sMap3D principal toricity magnitude (as calculated by the instrument software), and steep axis location were measured at a 16-mm chord diameter...
July 21, 2017: Eye & Contact Lens
https://www.readbyqxmd.com/read/28727605/in-vitro-compatibility-of-contact-lenses-with-corneal-epithelial-cells
#4
Ajay K Vijay, Zohra Fadli, Carol Lakkis, Chantal Coles-Brennan, Mark D P Willcox
PURPOSE: To determine the interaction of contact lenses of different materials with corneal epithelial cells grown in tissue culture. METHODS: Two different corneal epithelial cell lines were grown to confluence in culture media. Two hydrogel contact lenses with and without polyvinylpyrrolidone (PVP) {1-DAY ACUVUE MOIST (1-Day ACUVUE [hydrogel lenses]) and a silicone hydrogel contact lens, AIR OPTIX NIGHT & DAY} were removed from their blister packs, washed in phosphate-buffered saline, and applied to the cells...
July 18, 2017: Eye & Contact Lens
https://www.readbyqxmd.com/read/28727604/preclinical-development-of-ebi-005-an-il-1-receptor-1-inhibitor-for-the-topical-ocular-treatment-of-ocular-surface-inflammatory-diseases
#5
Joseph Kovalchin, Bracken King, Allyson Masci, Elizabeth Hopkins, Jeremy Fry, Jay Hou, Christian Li, Kelly Tenneson, Steve Weber, Gary Wolfe, Kathy Collins, Eric S Furfine
OBJECTIVE: Topical interleukin (IL)-1 receptor (R)1 blockade is therapeutically active in reducing signs and symptoms of dry eye disease. Herein, we describe in vitro and in vivo nonclinical Investigational New Drug (IND)-enabling studies of EBI-005, a novel protein chimera of IL-1β and IL-1 receptor antagonist (IL-1Ra or anakinra) that potently binds IL-1R1 and blocks signaling. These studies provide an assessment of receptor affinity, drug bioavailability, immunogenic response, safety, and tolerability in mice and rabbits...
July 18, 2017: Eye & Contact Lens
https://www.readbyqxmd.com/read/28719538/misight-assessment-study-spain-a-comparison-of-vision-related-quality-of-life-measures-between-misight-contact-lenses-and-single-vision-spectacles
#6
Alicia Ruiz Pomeda, Belén Pérez-Sánchez, Maria Del Pilar Cañadas Suárez, Francisco Luis Prieto Garrido, Ramón Gutiérrez-Ortega, César Villa-Collar
OBJECTIVES: Recent research has shown that concentric contact lenses (CLs) can be a way to control the progression of myopia. The purpose of the current study was to compare vision-related quality-of-life measures in children wearing distance single-vision (SV) spectacles versus MiSight CLs, a specific concentric design for myopia control. METHODS: Subjects aged 8 to 12 with myopia from -0.75 to -4.00 diopters (D) of sphere and astigmatism less than 1.00 D of cylinder were allocated to the lenses study group (MiSight) or control group (SV)...
July 14, 2017: Eye & Contact Lens
https://www.readbyqxmd.com/read/28719537/the-effect-of-slt-laser-application-on-iris-to-treat-sectorial-heterochromia-a-promising-technique
#7
Ayhan Basoglu, Uğur Çelik
The purpose of this study is to report a new and promising method for changing iris color in a sectorial heterochromia iridis patient. A 22-year-old man with a complaint of innate color disparity between his eyes presented to our clinic to seek medical advice. He underwent a comprehensive ophthalmic examination, including visual acuity, biomicroscopy, fundoscopy, intraocular pressure measurements, endothelial cell count, and evaluation of iridocorneal angle. The causes of acquired heterochromia were excluded...
July 14, 2017: Eye & Contact Lens
https://www.readbyqxmd.com/read/28628490/comparison-of-efficacy-of-difluprednate-0-05-and-loteprednol-gel-0-5-after-cataract-surgery
#8
Bryan Abessi, Lauren Brooksby, Robert L Schultze
PURPOSE: To compare the outcomes and complications of topical difluprednate 0.05% and loteprednol gel 0.5% after routine cataract surgery. METHODS: Subjects received either difluprednate emulsion 0.05% (n=30 eyes) or loteprednol gel 0.5% (n=30 eyes) after routine cataract surgery. Topical steroid drops were initiated 3 days before cataract surgery and continued for 2 weeks postoperatively. Anterior chamber (AC) cell grade, corneal edema, corneal pachymetry, visual acuity, ocular surface quality (Oxford scale), and intraocular pressure (IOP) were evaluated at 1 day, 1 week, and 1 month postoperatively...
June 16, 2017: Eye & Contact Lens
https://www.readbyqxmd.com/read/28628489/shifting-of-the-line-of-sight-in-tilted-disk-syndrome
#9
Pinar Kosekahya, Ozge Sarac, Mustafa Koc, Mehtap Caglayan, Gozde Hondur, Nurullah Cagil
OBJECTIVES: To investigate the shifting of the line of sight (LoS) and the refractive, topographic, and aberrometric parameters that may be associated with the shifting of the LoS in eyes with tilted disk syndrome (TDS). METHODS: Eighty left eyes of 80 subjects with TDS (Study Group) and 70 left eyes of 70 subjects with myopia and astigmatism (Control Group) were included in this study. Line-of-sight coordinates on the horizontal (x) and vertical (y) axes, refractive, topographic, and aberrometric parameters were evaluated...
June 16, 2017: Eye & Contact Lens
https://www.readbyqxmd.com/read/28617732/the-effects-of-latanoprost-with-benzalkonium-chloride-versus-travoprost-with-sofzia-on-the-ocular-surface
#10
Kamran Rahmatnejad, Christopher J Rapuano, Parul Ichhpujani, Sheryl S Wizov, Marlene R Moster, Lisa A Hark, L Jay Katz
PURPOSE: To assess ocular surface changes in participants using latanoprost with benzalkonium chloride (Xalatan) and travoprost with SofZia (Travatan Z). METHODS: In this prospective, open-label, nonrandomized cohort study, participants were classified into two groups: group 1 (n=28) naive to glaucoma therapy, group 2 (n=27) on previous Xalatan monotherapy in both eyes. Both groups started (or continued) Xalatan in the right eye and Travatan Z in the left eye. Baseline, 1-, and 2-month measurements of tear breakup time (TBUT), corneal staining score, conjunctival staining score, conjunctival hyperemia score, tear production, and intraocular pressure were obtained...
June 14, 2017: Eye & Contact Lens
https://www.readbyqxmd.com/read/28617731/retention-rates-in-new-contact-lens-wearers
#11
Anna Sulley, Graeme Young, Chris Hunt, Sarah McCready, Marie-Therese Targett, Ruth Craven
PURPOSE: To determine the retention rate (RR) for neophyte patients fitted with contact lenses (CLs) and to identify factors associated with retention and dropout. METHOD: This multisite, sponsor-masked registry study evaluated the 1-year status of neophyte CL wearers fitted in a representative range of UK practices. A total of 26 UK investigational sites each recruited up to 89 neophyte patients. The participants were requested to complete surveys at 1 month (±1 week from date of fitting), 3 months (±2 weeks), and 12 months (±3 weeks) online or through phone...
June 14, 2017: Eye & Contact Lens
https://www.readbyqxmd.com/read/28617730/eye-symptom-questionnaire-to-evaluate-anterior-eye-health
#12
Maria A Woodward, Nita G Valikodath, Paula Anne Newman-Casey, Leslie M Niziol, David C Musch, Paul P Lee
OBJECTIVES: Ophthalmologists assess eye complaints with a careful history and eye examination; however, other types of physicians have limited tools to evaluate anterior segment (AS) eye diseases. We identified the eye symptom questions that providers should ask to help determine the presence and urgency of AS eye diseases. METHODS: Persons with and without AS disease completed a self-report eye symptom questionnaire (ESQ) based on the National Institutes of Health Toolbox symptom items in an academic center's corneal and comprehensive eye clinics...
June 14, 2017: Eye & Contact Lens
https://www.readbyqxmd.com/read/28617729/demographic-characteristics-and-prescribing-patterns-of-scleral-lens-fitters-the-scope-study
#13
Cherie B Nau, Jennifer Harthan, Ellen Shorter, Joseph Barr, Amy Nau, Nicolette T Chimato, David O Hodge, Muriel M Schornack
OBJECTIVES: This study reports demographic characteristics of scleral lens providers and indications for scleral lens prescription as assessed by a worldwide online survey. METHODS: The Scleral Lenses in Current Ophthalmic Practice: an Evaluation (SCOPE) study group designed the online survey regarding current scleral lens prescription and management practices. The Mayo Clinic Survey Research Center administered the survey, which was open from January 15 to March 31, 2015...
June 14, 2017: Eye & Contact Lens
https://www.readbyqxmd.com/read/28617728/a-comparison-of-the-effects-of-orthokeratology-lens-medcall-lens-and-ordinary-frame-glasses-on-the-accommodative-response-in-myopic-children
#14
Xiaoxia Han, Dongjun Xu, Weizhong Ge, Zhi Wang, Xiaodong Li, Weihua Liu
OBJECTIVE: To observe and compare changes in accommodative response between myopic children wearing ordinary frame glasses (OFG), Mouldway orthokeratology lenses (M-OK), and medcall lenses (ML). METHODS: A total of 240 myopic children were divided into three groups: OFG [n=90]; M-OK [n=90]; and ML [n=60]). The diopter, accommodative lag, and binocular accommodative facility before wearing glasses (T0) and 1-year after wearing glasses (T1) were compared among the three groups...
June 14, 2017: Eye & Contact Lens
https://www.readbyqxmd.com/read/28617727/descemet-s-membrane-dehiscence-resulting-from-misdirected-viscoelastic-during-anterior-chamber-reformation
#15
Edward Chay, Ghulam Dastgir, Wayne Scott, Douglas Lazzaro
We report a case of Descemet's membrane detachment after inadvertent intrastromal injection of hyaluronic acid. Surgical removal was attempted with minimal but slow improvement. Near-complete resolution occurred with subsequent conservative management within 6 weeks.
June 14, 2017: Eye & Contact Lens
https://www.readbyqxmd.com/read/28617726/comparative-analysis-of-peripheral-corneal-geometry-in-health-and-keratoconus
#16
Enric Mas-Aixala, Joan Gispets, Núria Lupón, Genís Cardona
OBJECTIVES: To describe and compare corneal peripheral angles in normal and keratoconic eyes, to gain a better understanding of the topography of the periphery of the cornea in keratoconus and assist practitioners in the selection and fitting of large diameter contact lenses. METHODS: Eighty-eight eyes were included in the study, divided into three groups: healthy (A0, 28 eyes), keratoconus at stage I according to the Amsler-Krumeich classification (AI, 33 eyes) and keratoconus at stages II to IV (AII, 27 eyes)...
June 14, 2017: Eye & Contact Lens
https://www.readbyqxmd.com/read/28617725/depth-profile-assessment-of-the-early-phase-deposition-of-lysozyme-on-soft-contact-lens-materials-using-a-novel-in-vitro-eye-model
#17
Han Qiao, Chau-Minh Phan, Hendrik Walther, Lakshman N Subbaraman, Lyndon Jones
OBJECTIVE: To characterize the location of fluorescently labeled lysozyme on commercial contact lenses (CLs) using an in vitro eye model that simulates tear volume, tear flow, air exposure, and mechanical wear. METHODS: One commercially available conventional hydrogel CL material (etafilcon A) and three silicone hydrogel CL materials (balafilcon A, lotrafilcon B, and senofilcon A) were evaluated in this study. The CLs were mounted on the in vitro eye model and exposed to artificial tear fluid containing fluorescein isothiocyanate (FITC)-labeled lysozyme for 2 and 10 hrs...
June 14, 2017: Eye & Contact Lens
https://www.readbyqxmd.com/read/28617724/intracorneal-inlays-for-the-correction-of-presbyopia
#18
Perry S Binder
The current nonsurgical approaches for the correction of presbyopia are spectacles or contact lenses or the use of pharmaceuticals to create an artificial pupil and/or to stimulate residual accommodation. Refractive surgical procedures use a monovision approach and/or a multifocal corneal laser ablation with or without the induction of negative spherical aberration to improve near vision. More recently, new surgical approaches include intracorneal inlays. Inlay approaches include increasing corneal curvature alone, implanting a multifocal inlay, or by implanting a small aperture device that functions as a pinhole to restore unaided near and intermediate visual acuity...
June 14, 2017: Eye & Contact Lens
https://www.readbyqxmd.com/read/28557836/histopathology-of-failed-descemet-membrane-endothelial-transfer
#19
Jack Parker, Robert M Verdijk, Thomas M Müller, Itay Lavy, Marieke Bruinsma, Kathryn Colby, Perry S Binder, Gerrit R J Melles
OBJECTIVES: To describe the postmortem histologic features after an unsuccessful Descemet membrane endothelial transfer (DMET) and assess any potential clinical implications. METHODS: Postmortem, an eye from a patient who previously underwent unsuccessful DMET for pseudophakic bullous keratopathy (PPBK) was harvested and processed for morphologic evaluation. RESULTS: Clinically and histologically, the host cornea showed evidence of diffuse stromal edema...
May 26, 2017: Eye & Contact Lens
https://www.readbyqxmd.com/read/28557835/giant-ocular-surface-squamous-neoplasia-wrapping-whole-cornea
#20
Dhivya Ashok Kumar, Amar Agarwal
We present a giant ocular surface squamous neoplasia (OSSN) measuring approximately 20×18 mm arising from the fornix and wrapping the entire 12 clock hours of the cornea. The surgical excision was performed with preservation of the corneal surface. A 3-mm clear margin was obtained all around the mass. The histopathology confirmed as moderately differentiated squamous cell carcinoma with clear margins. The postoperative period was uneventful, and a clear cornea without a residual scar with best corrected visual acuity of 20/20 was attained...
May 26, 2017: Eye & Contact Lens
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