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Liver International: Official Journal of the International Association for the Study of the Liver

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https://www.readbyqxmd.com/read/30417579/clinical-outcomes-and-management-of-patients-with-chronic-hepatitis-b-and-liver-stiffness-measurement-in-the-grey-zone
#1
Ken Liu, Vincent Wai-Sun Wong, Lilian Yan Liang, Grace Chung-Yan Lui, Henry Lik-Yuen Chan, Grace Lai-Hung Wong
BACKGROUND: A significant number of patients have liver stiffness measurements (LSM) in the grey zone where liver biopsy is recommended. AIMS: To study chronic hepatitis B (CHB) patients with initial LSM in the grey zone with regards to rates of liver biopsy, repeat LSM, and outcomes. METHODS: Consecutive CHB patients who underwent transient elastography (TE) from August 2006 to July 2017 were retrospectively studied. Liver-related events (LRE) were defined as HCC or cirrhotic complications...
November 12, 2018: Liver International: Official Journal of the International Association for the Study of the Liver
https://www.readbyqxmd.com/read/30411848/liver-decompensation-in-hiv-hepatitis-b-coinfection-in-the-cart-era-does-not-seem-increased-compared-to-hepatitis-b-mono-infection
#2
Faydra I Lieveld, Colette Smit, Clemens Richter, Karel J van Erpecum, Bernhard W M Spanier, Elisabeth H Gisolf, Jan M Vrolijk, Peter D Siersema, Andy I M Hoepelman, Peter Reiss, Joop E Arends
BACKGROUND & AIMS: HIV/hepatitis B virus (HBV) coinfected subjects are thought to have faster progression to end-stage liver disease (ESLD) than HBV mono-infected subjects. We assessed whether this remains in the current cART-era. METHODS: Data from subjects with follow-up completion post-2003 were compared between HIV/HBV coinfected subjects in the Dutch HIV Monitoring database and HBV mono-infected subjects from two centers. The primary outcome of composite ESLD included portal hypertension, decompensated cirrhosis, hepatocellular carcinoma, liver transplantation, and liver-related mortality...
November 9, 2018: Liver International: Official Journal of the International Association for the Study of the Liver
https://www.readbyqxmd.com/read/30394651/progressive-resistance-training-prevents-loss-of-muscle-mass-and-strength-in-bile-duct-ligated-rats
#3
Luise Aamann, Rafael Ochoa-Sanchez, Mariana Oliveira, Mélanie Tremblay, Chantal Bémeur, Gitte Dam, Hendrik Vilstrup, Niels Kristian Aagaard, Christopher Rose
BACKGROUND: Loss of muscle mass and strength is common in cirrhosis and increases the risk of hyperammonemia and hepatic encephalopathy. Resistance training optimizes muscle mass and strength in several chronic diseases. However, the beneficial effects of resistance training in cirrhosis remains to be investigated. Bile duct ligated (BDL)-rats develop chronic liver disease, hyperammonemia, reduced muscle mass and strength. Our aim was to test the effects of resistance training on muscle mass, function and ammonia metabolism in BDL-rats...
November 5, 2018: Liver International: Official Journal of the International Association for the Study of the Liver
https://www.readbyqxmd.com/read/30367552/erc-and-ptcd-in-biliary-strictures-after-liver-transplantation-long-term-outcome-predictors-and-influence-on-patient-survival
#4
Melina Heinemann, Bita Tafrishi, Sven Pischke, Lutz Fischer, Thomas Rösch, Ansgar W Lohse, Martina Sterneck, Ulrike W Denzer
BACKGROUND & AIMS: Biliary strictures are common complications after orthotopic liver transplantation (OLT). Endoscopic retrograde cholangiography (ERC) evolved as standard and percutaneous transhepatic cholangiodrainage (PTCD) as alternative therapy. This study analysed predictors of long-term success of biliary strictures after ERC and/or PTCD and its impact on patient survival. METHODS: All adult patients with biliary strictures receiving ERC and/or PTCD between 2009 and 2015 at the University Medical Center Hamburg-Eppendorf were retrospectively analysed...
October 26, 2018: Liver International: Official Journal of the International Association for the Study of the Liver
https://www.readbyqxmd.com/read/30358050/causality-between-non-alcoholic-fatty-liver-disease-and-risk-of-cardiovascular-disease-and-type-2-diabetes-a-meta-analysis-with-bias-analysis
#5
Amy E Morrison, Francesco Zaccardi, Kamlesh Khunti, Melanie J Davies
BACKGROUND & AIMS: A causal association of non-alcoholic fatty liver disease (NAFLD) with cardiovascular disease (CVD) and type 2 diabetes (T2DM) remains unproved. We aimed to quantify the likelihood of causality examining the sensitivity of observational associations to possible confounding. METHODS: Studies investigating longitudinal associations of NAFLD with CVD or T2DM were searched on June 5th , 2018. Study-specific relative risks (RRs) were combined in random-effects meta-analyses and pooled estimates used in bias analyses...
October 25, 2018: Liver International: Official Journal of the International Association for the Study of the Liver
https://www.readbyqxmd.com/read/30347513/chronic-kidney-disease-is-independently-associated-with-increased-mortality-in-patients-with-non-alcoholic-fatty-liver-disease
#6
James Paik, Pegah Golabi, Zahra Younoszai, Alita Mishra, Gregory Trimble, Zobair M Younossi
BACKGROUND & AIMS: Non-alcoholic fatty liver disease (NAFLD) and chronic kidney disease (CKD) share similar pathophysiologic features. Our aim was to assess the association between different stages of CKD and mortality in patients with NAFLD. METHODS: NHANES-III-linked mortality files were utilized. NAFLD was diagnosed by hepatic ultrasound and CKD was defined according to the Kidney Disease Improving Global outcomes guideline. Multivariable Cox proportional hazard model was used to assess the effect of CKD on overall and cardiovascular mortality...
October 22, 2018: Liver International: Official Journal of the International Association for the Study of the Liver
https://www.readbyqxmd.com/read/30347485/longitudinal-analysis-of-risk-of-non-alcoholic-fatty-liver-disease-nafld-in-adulthood
#7
Daniel J Cuthbertson, Emily Brown, Juha Koskinen, Costan G Magnussen, Nina Hutri-Kähönen, Matthew Sabin, Päivi Tossavainen, Eero Jokinen, Tomi Laitinen, Jorma Viikari, Olli T Raitakari, Markus Juonala
BACKGROUND & AIMS: We aimed to determine how childhood body mass index (BMI) and metabolic health, along with change in BMI between childhood and adulthood, determine the risk of adult non-alcoholic fatty liver disease (NAFLD). METHODS: Data from 2,020 participants aged 3-18 years at baseline, followed up 31 years later, was examined to assess the utility of four childhood metabolic phenotypes (metabolic groups I: normal BMI, no metabolic disturbances; II: normal BMI, one or more metabolic disturbances; III: overweight/obese, no metabolic disturbances; IV: overweight/obese, one or more metabolic disturbances) and four life-course adiposity phenotypes (adiposity group 1: normal child and adult BMI; 2, high child, normal adult BMI; 3, normal child BMI, high adult BMI; 4, high child and adult BMI) in predicting adult NAFLD...
October 22, 2018: Liver International: Official Journal of the International Association for the Study of the Liver
https://www.readbyqxmd.com/read/30339724/percutaneous-transgastral-biliodigestive-diversion-as-treatment-option-for-bric
#8
Leona Dold, Alexandra Tschada, Christian P Strassburg, Tobias J Weismüller
A 51-year-old woman was hospitalized with jaundice, pruritus and nausea. Four weeks before a common bile duct stone had been removed by endoscopic retrograde cholangiopancreatography (ERCP) with papillotomy. Blood tests showed isolated bilirubinaemia (15 mg/dl), while all liver enzymes were in the normal range. In a second ERCP we saw a wide opened major papilla with unimpaired bile flow and without any stones or strictures. Liver histology showed portal inflammation and cholestasis and genetic testing revealed homozygous mutation in the ABCB11 gene, which encodes a bile salt exporter pump...
October 19, 2018: Liver International: Official Journal of the International Association for the Study of the Liver
https://www.readbyqxmd.com/read/30318826/extent-of-portal-vein-tumor-thrombosis-in-patients-with-hepatocellular-carcinoma-the-more-the-worse
#9
Aline Mähringer-Kunz, Verena Steinle, Christoph Düber, Arndt Weinmann, Sandra Koch, Irene Schmidtmann, Sebastian Schotten, Jan Bernd Hinrichs, Dirk Graafen, Daniel Pinto Dos Santos, Peter Robert Galle, Roman Kloeckner
BACKGROUND&AIMS: Portal vein tumor thrombosis (PVTT) has a significant impact on the prognosis of patients with hepatocellular carcinoma (HCC). The degree of PVTT varies from sub-/segmental invasion to complete occlusion of the main trunk. Aim of this study was to evaluate whether the degree of PVTT correlates with prognosis. METHODS: A total of 1317 patients with HCC treated at our tertiary referral center between January 2005 and December 2016 were included...
October 14, 2018: Liver International: Official Journal of the International Association for the Study of the Liver
https://www.readbyqxmd.com/read/30312513/potential-mechanisms-linking-gut-microbiota-and-portal-hypertension
#10
Gyorgy Baffy
Gut microbiota is the largest collection of commensal microorganisms in the human body, engaged in reciprocal cellular and molecular interactions with the liver. This mutually beneficial relationship may break down and result in dysbiosis, associated with disease phenotypes. Altered composition and function of gut microbiota has been implicated in the pathobiology of nonalcoholic fatty liver disease (NAFLD), a prevalent condition linked to obesity, insulin resistance, and endothelial dysfunction. NAFLD may progress to cirrhosis and portal hypertension, which is the result of increased intrahepatic vascular resistance and altered splanchnic circulation...
October 12, 2018: Liver International: Official Journal of the International Association for the Study of the Liver
https://www.readbyqxmd.com/read/30312003/the-impact-of-hcv-eradication-by-direct-acting-antivirals-on-the-transition-of-precancerous-hepatic-nodules-to-hcc-a-prospective-observational-study
#11
Hidenori Toyoda, Takashi Kumada, Toshifumi Tada, Kazuyuki Mizuno, Yasuhiro Sone, Tomoyuki Akita, Junko Tanaka, Philip J Johnson
BACKGROUND & AIMS: It remains controversial whether the eradication of hepatitis C virus (HCV) by interferon (IFN)-free anti-HCV therapy using direct-acting antivirals (DAAs) suppresses or promotes hepatocellular carcinoma (HCC) development. We investigated the influence of HCV eradication by DAA therapy on HCC development, by observing changes of non-hypervascular hypointense nodules (NHHNs) by gadolinium-ethoxybenzyl-diethylenetriamine pentaacetic acid-enhanced magnetic resonance imaging (EOB-MRI)...
October 12, 2018: Liver International: Official Journal of the International Association for the Study of the Liver
https://www.readbyqxmd.com/read/30300961/periodontitis-is-associated-with-incident-chronic-liver-disease-a-population-based-cohort-study
#12
Jaana Helenius-Hietala, Anna Liisa Suominen, Hellevi Ruokonen, Matti Knuuttila, Pauli Puukka, Antti Jula, Jukka H Meurman, Fredrik Åberg
BACKGROUND & AIMS: Chronic liver disease is a major health concern worldwide and the identification of novel modifiable risk factors may benefit subjects at risk. Few studies have analyzed periodontitis as a risk factor for liver complications. We studied whether periodontitis is associated with incident severe liver disease. METHODS: The study comprised 6165 individuals without baseline liver disease who participated in the Finnish population-based Health 2000 Survey (BRIF8901) during 2000-2001, a nationally representative cohort...
October 9, 2018: Liver International: Official Journal of the International Association for the Study of the Liver
https://www.readbyqxmd.com/read/30298568/predictors-of-nonalcoholic-steatohepatitis-and-significant-fibrosis-in-non-obese-nonalcoholic-fatty-liver-disease
#13
Donghee Kim, Won Kim, Sae Kyung Joo, Jung Ho Kim, Stephen A Harrison, Zobair M Younossi, Aijaz Ahmed
AIMS: We compared (a) demographic and clinical characteristics and (b) determinants of nonalcoholic steatohepatitis and significant fibrosis in non-obese and obese nonalcoholic fatty liver disease. METHODS: A cross-sectional study of 664 Asian subjects (mean age 53.1 years; men 50.3%) with biopsy-proven nonalcoholic fatty liver disease and controls was conducted. Subjects were divided by their body mass index into obese (body mass index ≥25 kg/m2 ) and non-obese (body mass index <25 kg/m2 )...
October 8, 2018: Liver International: Official Journal of the International Association for the Study of the Liver
https://www.readbyqxmd.com/read/30280461/fibrosis-matched-outcomes-between-chronic-hepatitis-b-patients-with-drug-induced-virological-response-and-inactive-carriers
#14
Hye Soo Kim, Oidov Baatarkhuu, Hye Won Lee, Jun Yong Park, Do Young Kim, Sang Hoon Ahn, Kijun Song, Kwang-Hyub Han, Beom Kyung Kim, Seung Up Kim
BACKGROUND & AIMS: We compared the risk of hepatocellular carcinoma (HCC) development between patients with chronic hepatitis B (CHB) who achieved virological response (VR; HBV-DNA < 2000 IU/mL) with nucleos(t)ide analogues (NUCs) treatment (NUC-VR group) and patients with inactive CHB phase (ICHBP group). METHODS: To adjust for imbalances between NUC-VR and ICHBP groups, propensity score matching (PSM) models with 1:1 ratios were performed. RESULTS: This study included 2032 patients (n = 1291 in NUC-VR group and n = 741 in ICHBP group)...
October 2, 2018: Liver International: Official Journal of the International Association for the Study of the Liver
https://www.readbyqxmd.com/read/30276961/applicability-of-sepsis-3-criteria-and-qsofa-in-patients-with-cirrhosis-hospitalized-for-bacterial-infections
#15
Fernanda Cristina de Augustinho, Tamara Liana Zocche, Ariane Borgonovo, Dariana Carla Maggi, Elayne Cristina de Morais Rateke, Camila Matiollo, Esther Buzaglo Dantas-Correa, Janaína Luz Narciso-Schiavon, Leonardo Lucca Schiavon
BACKGROUND AND AIMS: An algorithm including Sepsis-3 criteria and qSOFA was recently proposed to predict severity of infection in cirrhosis. However, its applicability among patients without a baseline SOFA available for Sepsis-3 definition is unknown. We sought to investigate the applicability and prognostic value of qSOFA and Sepsis-3 criteria in patients with cirrhosis hospitalized for bacterial infections, without pre-hospitalization SOFA. METHODS: In this cohort study, 164 patients were followed up to 30 days...
October 1, 2018: Liver International: Official Journal of the International Association for the Study of the Liver
https://www.readbyqxmd.com/read/30276959/intention-to-treat-analysis-of-liver-transplantation-for-hepatocellular-carcinoma-the-impact-of-pre-existing-diabetes-mellitus
#16
Zhiwei Li, Zhenzhen Gao, Jie Xiang, Jie Zhou, Sheng Yan, Zhenhua Hu
BACKGROUND & AIMS: Diabetes mellitus is known to negatively impact the outcome of liver transplant; however, data are scarce regarding risk of waitlist dropout and tumour recurrence in patients with hepatocellular carcinoma. We examined the impact of diabetes mellitus on the outcomes of candidates with hepatocellular carcinoma on an intention-to-treat basis. METHODS: Our study included 15 776 candidates with hepatocellular carcinoma diagnosis on the Scientific Registry of Transplant Recipients database from 2008 to 2015 to evaluate the risk of waitlist dropout, hepatocellular carcinoma recurrence and overall survival...
October 1, 2018: Liver International: Official Journal of the International Association for the Study of the Liver
https://www.readbyqxmd.com/read/30276951/invasive-fungal-infections-amongst-patients-with-acute-on-chronic-liver-failure-at-high-risk-for-fungal-infections
#17
Nipun Verma, Shreya Singh, Sunil Taneja, Ajay Duseja, Virendra Singh, Radha K Dhiman, Arunaloke Chakrabarti, Yogesh K Chawla
AIMS: To study the prevalence, risk factors, role of serum biomarkers for diagnosis and impact of invasive fungal infections (IFIs) in patients with acute-on-chronic liver failure (ACLF). METHODS: An analysis of IFI in patients with ACLF (EASL criteria) was conducted retrospectively. The diagnosis of IFI in clinically suspected patients was based on EORTC/MSG criteria. The demographical, clinical, laboratory details and outcomes were analysed. RESULTS: Out of 264 patients with ACLF, 54 (20...
October 1, 2018: Liver International: Official Journal of the International Association for the Study of the Liver
https://www.readbyqxmd.com/read/30269440/circulating-markers-of-gut-barrier-function-associated-with-disease-severity-in-primary-sclerosing-cholangitis
#18
Amandeep K Dhillon, Martin Kummen, Marius Trøseid, Sissel Åkra, Evaggelia Liaskou, Bjørn Moum, Mette Vesterhus, Tom H Karlsen, Ingebjørg Seljeflot, Johannes R Hov
BACKGROUND & AIMS: One important hypothesis in primary sclerosing cholangitis pathophysiology suggests that bacterial products from an inflamed leaky gut lead to biliary inflammation. We aimed to investigate whether circulating markers of bacterial translocation were associated with survival in a Norwegian primary sclerosing cholangitis cohort. METHODS: Serum levels of zonulin, intestinal fatty acid binding protein, soluble CD14, lipopolysaccharide and lipopolysaccharide-binding protein were measured in 166 primary sclerosing cholangitis patients and 100 healthy controls...
September 30, 2018: Liver International: Official Journal of the International Association for the Study of the Liver
https://www.readbyqxmd.com/read/30261128/human-beta-defensin-1-is-a-highly-predictive-marker-of-mortality-in-patients-with-acute-on-chronic-liver-failure
#19
Iliana Mani, Alexandra Alexopoulou, Larisa Vasilieva, Emilia Hadziyannis, Danai Agiasotelli, Myrianthi Bei, Theodoros Alexopoulos, Spyros P Dourakis
BACKGROUND & AIM: Human beta-defensin-1 (hBD-1) is a natural antimicrobial peptide expressed in the epithelia of multiple tissues including the digestive tract. In the current study, hBD-1 levels were determined in different subsets of patients with decompensated cirrhosis including acute-on-chronic liver failure (ACLF). In addition, the association with mortality of hBD-1, C-reactive protein (CRP) and procalcitonin (PCT) was assessed. METHODS: A total of 125 patients were divided into three groups: 39 with ACLF (derivation cohort), 46 with acute decompensation without ACLF (AD) and 40 with decompensated cirrhosis without an acute event (DC)...
September 27, 2018: Liver International: Official Journal of the International Association for the Study of the Liver
https://www.readbyqxmd.com/read/30260075/snp-rs688-within-the-low-density-lipoprotein-receptor-ldl-r-gene-associates-with-hcv-susceptibility
#20
Gaby S Steba, Sylvie M Koekkoek, Michael W T Tanck, Joost W Vanhommerig, Jan T M van der Meer, David Kwa, Kees Brinkman, Maria Prins, Ben Berkhout, Georgios Pollakis, Richard Molenkamp, Janke Schinkel, William A Paxton
BACKGROUND & AIMS: Despite high-risk behaviour, 10%-20% of HCV multiple exposed individuals remain uninfected (MEU), whilst the remainder become infected (MEI). We hypothesize that host factors play a role in HCV susceptibility. We aimed to identify polymorphisms in host genes that encode for proteins involved in viral entry: CD81, Scavenger receptor 1 (SR-1), Low-density lipoprotein receptor (LDL-R), Claudin-1 (CLDN1), Occludin (OCLN) and Niemann-Pick C1-like 1 (NPC1L1). METHODS: Multiple exposed infected and MEU from two observational cohorts were selected...
September 27, 2018: Liver International: Official Journal of the International Association for the Study of the Liver
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