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Liver International: Official Journal of the International Association for the Study of the Liver

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https://www.readbyqxmd.com/read/27896931/risk-of-empyema-in-patients-with-chronic-liver-disease-and-cirrhosis-a-nationwide-population-based-cohort-study
#1
Te-Chun Shen, Chia-Hung Chen, Hsueh-Chou Lai, Cheng-Li Lin, Chih-Yen Tu, Te-Chun Hsia, Chuen-Ming Shih, Wu-Huei Hsu, Fung-Chang Sung
BACKGROUND: Empyema is an important complication for patients with chronic liver disease and cirrhosis (CLDC). However, no study has investigated this relationship by using a population-based cohort study. METHODS: We used the National Health Insurance Research Data of Taiwan to identify a cohort of 76,027 CLDC patients newly diagnosed in 2000-2010 and a comparison cohort without CLDC of same size matched by age, gender and the year of diagnosis. The occurrence of empyema was monitored until the end of 2011...
November 29, 2016: Liver International: Official Journal of the International Association for the Study of the Liver
https://www.readbyqxmd.com/read/27896895/five-year-efficacy-and-safety-of-tenofovir-based-salvage-therapy-for-patients-with-chronic-hepatitis-b-who-previously-failed-lam-adv-therapy
#2
Lucy Lim, Alexander Thompson, Scott Patterson, Jacob George, Simone Strasser, Alice Lee, William Sievert, Amanda Nicoll, Paul Desmond, Stuart Roberts, Kaye Marion, Scott Bowden, Stephen Locarnini, Peter Angus
BACKGROUND: Multidrug resistant HBV continues to be an important clinical problem. The TDF-109 study demonstrated that TDF±LAM is effective salvage therapy through 96 weeks for LAM resistant patients who previously failed ADV add-on or switch therapy. We evaluated the 5 year efficacy and safety outcomes in patients receiving long-term TDF±LAM in the TDF-109 study. METHODS: 59 patients completed the first phase of the TDF-109 study and 54/59 were rolled over into a long-term prospective open-label study of TDF±LAM 300mg daily...
November 29, 2016: Liver International: Official Journal of the International Association for the Study of the Liver
https://www.readbyqxmd.com/read/27891768/hyperuricemia-and-risk-of-nonalcoholic-fatty-liver-disease-a-meta-analysis
#3
Karn Wijarnpreecha, Panadeekarn Panjawatanan, Natasorn Lekuthai, Charat Thongprayoon, Wisit Cheungpasitporn, Patompong Ungprasert
BACKGROUND/OBJECTIVES: The association between hyperuricemia and nonalcoholic fatty liver disease (NAFLD), one of the leading causes of cirrhosis worldwide, has been demonstrated in recent epidemiologic studies. This meta-analysis was conducted to summarize all available data and to estimate the risk of NAFLD among subjects with hyperuricemia. METHODS: Comprehensive literature review was conducted using MEDLINE and EMBASE database through August 2016 to identify studies that compared the risk of NAFLD among subjects with hyperuricemia versus those with normal uric acid level...
November 28, 2016: Liver International: Official Journal of the International Association for the Study of the Liver
https://www.readbyqxmd.com/read/27891750/epidemiology-and-outcomes-of-primary-sclerosing-cholangitis-with-and-without-inflammatory-bowel-disease-in-an-australian-cohort
#4
Ken Liu, Ruoxi Wang, Viraj Kariyawasam, Mark Wells, Simone I Strasser, Geoff McCaughan, Crispin Corte, Rupert W Leong
BACKGROUND&AIMS: Epidemiological data on primary sclerosing cholangitis (PSC) outside the Northern hemisphere is limited. Similarly, the impact of inflammatory bowel disease (IBD) on PSC outcomes remains unclear. We aimed to study the epidemiology and outcomes of PSC patients with and without IBD in an Australian cohort. METHODS: We retrospectively studied PSC patients attending two tertiary referral hospitals over 20years. Diagnosis of PSC was made according to international guidelines by positive cholangiography and/or liver biopsy (for small duct PSC) with supporting clinical and laboratory evidence RESULTS: 208 PSC patients (61% male) were studied (2,271patient-years follow-up)...
November 28, 2016: Liver International: Official Journal of the International Association for the Study of the Liver
https://www.readbyqxmd.com/read/27885796/hepatocellular-carcinomas-with-intracellular-hyaline-bodies-have-a-poor-prognosis
#5
Ariane Aigelsreiter, Jens Neumann, Martin Pichler, Judith Halasz, Kurt Zatloukal, Andrea Berghold, Philipp Douschan, Florian Rainer, Rudolf Stauber, Johannes Haybaeck, Helmut Denk, Carolin Lackner
BACKGROUND & AIMS: Mallory-Denk-bodies (MDB) and intracellular hyaline bodies (IHB) are cytoplasmic inclusions found in a subset of hepatocellular carcinoma (HCC). MDB are mainly composed of the intermediate filament proteins keratin (K) 8 and K18, the cellular stress- and adapter-protein sequestosome 1/p62 (p62) and ubiquitin, whereas IHB consist of p62 and/or ubiquitin. Of note, cytoplasmic inclusions containing p62 can serve as markers of suppressed autophagy which in turn has been associated with poor prognosis...
November 25, 2016: Liver International: Official Journal of the International Association for the Study of the Liver
https://www.readbyqxmd.com/read/27865034/prevention-of-hepatitis-c-recurrence-by-bridging-sofosbuvir-ribavirin-from-pre-to-post-liver-transplant-a-real-life-strategy
#6
Maria Francesca Donato, Cristina Morelli, Renato Romagnoli, Federica Invernizzi, Chiara Mazzarelli, Rosa Maria Iemmolo, Marzia Montalbano, Ilaria Lenci, Sherrie Bhoori, Giulia Pieri, Sonia Berardi, Paolo Caraceni, Silvia Martini
BACKGROUND AND AIMS: Hepatitis C virus (HCV) reinfection following liver transplant (LT) is associated with reduced graft and patients survival. Before transplant, Sofosbuvir/Ribavirin (SOF/R) treatment prevents recurrent HCV in 96% of those patients achieving viral suppression for at least 4 weeks before transplant. We evaluated whether a bridging SOF-regimen from pre to post-transplant is safe and effective to prevent HCV recurrence in those patients with less than 4 week HCV-RNA undetectability at the time of transplant...
November 19, 2016: Liver International: Official Journal of the International Association for the Study of the Liver
https://www.readbyqxmd.com/read/27862856/liver-stiffness-and-platelet-count-for-identifying-patients-with-compensated-liver-disease-at-low-risk-of-variceal-bleeding
#7
Astrid Marot, Eric Trépo, Christopher Doerig, Alain Schoepfer, Christophe Moreno, Pierre Deltenre
The 2015 Baveno VI guidelines recommend against performing upper gastrointestinal endoscopy in patients with compensated cirrhosis who have a liver stiffness <20 kPa and a platelet count >150'000/mm³ because of a low prevalence of varices at risk of bleeding in this population AIM: Synthesize the available evidence on the usefulness of the combined use of liver stiffness and platelet count to identify patients without esophageal varices METHODS: Meta-analysis of trials evaluating the usefulness of a given cut-off for liver stiffness and platelet count to rule out the presence of esophageal varices RESULTS: Fifteen studies were included...
November 18, 2016: Liver International: Official Journal of the International Association for the Study of the Liver
https://www.readbyqxmd.com/read/27860293/thrombocytopenia-in-chronic-liver-disease
#8
Markus Peck-Radosavljevic
Thrombocytopenia is a common haematological disorder in patients with chronic liver disease (CLD). It is multifactorial and severity of liver disease is the most influential factor. Due to the increased risk of bleeding, thrombocytopenia may impact upon medical procedures, such as surgery or liver biopsy. The pathophysiology of thrombocytopenia in CLD has long been associated with the hypothesis of hypersplenism, where portal hypertension causes pooling and sequestration of all corpuscular elements of the blood, predominantly thrombocytes, in the enlarged and congested spleen...
November 17, 2016: Liver International: Official Journal of the International Association for the Study of the Liver
https://www.readbyqxmd.com/read/27860118/association-between-serum-soluble-cd14-and-il-8-levels-and-clinical-outcome-in-primary-biliary-cholangitis
#9
Takeji Umemura, Tomohiro Sekiguchi, Satoru Joshita, Tomoo Yamazaki, Naoyuki Fujimori, Soichiro Shibata, Yuki Ichikawa, Michiharu Komatsu, Akihiro Matsumoto, Zakera Shums, Gary L Norman, Eiji Tanaka, Masao Ota
BACKGROUND & AIMS: Primary biliary cholangitis (PBC) is an autoimmune liver disease characterized by portal inflammation and immune-mediated destruction of intrahepatic bile ducts that often leads to liver decompensation, and liver failure. Although the biochemical response to ursodeoxycholic acid (UDCA) can predict disease outcome in PBC, few biomarkers have been identified as prognostic tools applicable prior to UDCA treatment. We therefore sought to identify such indicators of long-term outcome in PBC in the Japanese population...
November 17, 2016: Liver International: Official Journal of the International Association for the Study of the Liver
https://www.readbyqxmd.com/read/27860186/profiles-of-mirnas-in-serum-in-severe-acute-drug-induced-liver-injury-and-their-prognostic-significance
#10
Mark W Russo, Nury Steuerwald, Harry J Norton, William E Anderson, David Foureau, Naga Chalasani, Robert J Fontana, Paul B Watkins, Jose Serrano, Herbert L Bonkovsky
BACKGROUND & AIMS: Drug induced liver injury (DILI) is challenging because of the lack of biomarkers to predict mortality. Our aim was to describe miRNA changes in sera of subjects with acute idiosyncratic DILI and determine if levels of miRNAs were associated with 6 month mortality. METHODS: Clinical data and sera were collected from subjects enrolled in the Drug Induced Liver Injury Network prospective study. miRNAs were isolated from serum obtained from 78 subjects within 2 weeks of acute DILI and followed up for 6 months or longer...
November 12, 2016: Liver International: Official Journal of the International Association for the Study of the Liver
https://www.readbyqxmd.com/read/27860156/hepatotoxicity-of-statins-and-other-lipid-lowering-agents
#11
REVIEW
Einar S Björnsson
Statins are generally well tolerated and adverse effects are relatively rare. Clinical trials are underpowered to detect uncommon adverse effects such as idiosyncratic drug-induced liver injury. This review is aimed at covering the current knowledge on the hepatotoxicity associated with statins and other lipid lowering drugs. Both atorvastatin and simvastatin have been associated with more than 50 case reports of liver injury and other statins have been implicated in this type of liver injury as well. Idiosyncratic liver injury due to statins has been reported to occur 1...
November 8, 2016: Liver International: Official Journal of the International Association for the Study of the Liver
https://www.readbyqxmd.com/read/27885811/17-%C3%AE-estradiol-inhibits-hepatitis-c-virus-mainly-by-interference-with-the-release-phase-of-its-life-cycle
#12
Andrea Magri, Matteo N Barbaglia, Chiara Z Foglia, Elisa Boccato, Michela E Burlone, Sarah Cole, Paola Giarda, Elena Grossini, Arvind H Patel, Rosalba Minisini, Mario Pirisi
BACKGROUND & AIMS: Oestrogen and oestrogen-mediated signalling protect from hepatitis C virus through incompletely understood mechanisms. We aimed to ascertain which phase(s) of hepatitis C virus life cycle is/are affected by oestrogens. METHODS: Huh7 cells infected with the JFH1 virus (genotype 2a) were exposed to dehydroepiandrosterone, testosterone, progesterone and 17β-estradiol (tested with/without its receptor antagonist fulvestrant). Dose-response curves were established to calculate half maximal inhibitory concentration values...
November 7, 2016: Liver International: Official Journal of the International Association for the Study of the Liver
https://www.readbyqxmd.com/read/27885793/lipopolysaccharide-binding-protein-predicts-decompensated-cirrhosis-mortality-it-is-too-early
#13
LETTER
Yanyan Xuan, Yiyi Wu, Guoxiang Li, Naibin Yang
No abstract text is available yet for this article.
November 7, 2016: Liver International: Official Journal of the International Association for the Study of the Liver
https://www.readbyqxmd.com/read/27886440/the-forgotten-place-of-radioembolization-for-the-treatment-of-hepatocellular-carcinoma-with-portal-vein-tumour-thrombosis
#14
LETTER
Giovanni Battista Levi Sandri, Quirino Lai, Pierleone Lucatelli
No abstract text is available yet for this article.
November 6, 2016: Liver International: Official Journal of the International Association for the Study of the Liver
https://www.readbyqxmd.com/read/27804195/the-value-of-cure-associated-with-treating-treatment-na%C3%A3-ve-chronic-hepatitis-c-genotype-1-are-the-new-all-oral-regimens-good-value-to-society
#15
Zobair M Younossi, Haesuk Park, Douglas Dieterich, Sammy Saab, Aijaz Ahmed, Stuart C Gordon
BACKGROUND & AIMS: All-oral regimens are associated with high cure rates in hepatitis C virus-genotype 1 (HCV-GT1) patients. Our aim was to assess the value of cure to the society for treating HCV infection. METHODS: Markov model for HCV-GT1 projected long-term health outcomes, life years, and quality-adjusted life years (QALYs) gained. The model compared second-generation triple (sofosbuvir+pegylated interferon+ribavirin [PR] and simeprevir+PR) and all-oral (ledipasvir/sofosbuvir and ombitasvir+paritaprevir/ritonavir+dasabuvir±ribavirin) therapies with no treatment...
November 2, 2016: Liver International: Official Journal of the International Association for the Study of the Liver
https://www.readbyqxmd.com/read/27804192/risk-stratification-for-locally-advanced-hepatocellular-carcinoma-using-pretreatment-alpha-foetoprotein-and-18-f-fluoro-2-deoxyglucose-positron-emission-tomography
#16
Woo Joong Rhee, Sang Hyun Hwang, Hwa Kyung Byun, Mijin Yun, Kwang-Hyub Han, Jinsil Seong
BACKGROUND & AIMS: We investigated the significance of (18) F-fluoro-2-deoxyglucose positron emission tomography ((18) F-FDG PET) parameters and alpha-foetoprotein (AFP) levels in patients with locally advanced hepatocellular carcinoma (LA-HCC). METHODS: We retrospectively analysed data of 228 patients with LA-HCC who underwent pretreatment (18) F-FDG PET between January 2003 and December 2013. All patients were treated using liver-directed therapy involving radiotherapy...
November 2, 2016: Liver International: Official Journal of the International Association for the Study of the Liver
https://www.readbyqxmd.com/read/27797424/hepatic-resection-is-superior-to-transarterial-chemoembolization-for-treating-intermediate-stage-hepatocellular-carcinoma
#17
LETTER
Jian-Hong Zhong, Ning-Fu Peng, Xue-Mei You, Liang Ma, Le-Qun Li
Pecorelli et al.(1) analyzed 485 consecutive patients with Barcelona Clinic Liver Cancer (BCLC) stage B hepatocellular carcinoma (HCC) from the ITA.LI.CA database. First-line therapy was transarterial chemoembolization (TACE) for 51% of patients and resection for 32% of patients. Their analysis of overall and recurrence-free survival showed resection to be superior to TACE. We applaud Pecorelli et al. for tackling the still-controversial question(2-3) of what first-line therapy is most effective for patients with BCLC-B HCC...
October 31, 2016: Liver International: Official Journal of the International Association for the Study of the Liver
https://www.readbyqxmd.com/read/27791331/four-year-entecavir-therapy-reduces-hepatocellular-carcinoma-cirrhotic-events-and-mortality-in-chronic-hepatitis-b-patients
#18
LETTER
Bin-Qiao Wang, Yong-Lin Wang, Ke-Qing Shi
This is in reference to the article by SU TH et al.(1). They had recuited 1818 treatment-naïve patients with cirrhosis and baseline HBV-DNA≥2000 IU/mL and found a significant decrease of the development of hepatocellular carcinoma(HCC), liver-related and all-cause mortality as well as cirrhotic complications including variceal bleeding, spontaneous bacterial peritontis(SBP) due to the long-term entecavir therapy. However, to our understanding, there are still some key points worth up for discussion. This article is protected by copyright...
October 28, 2016: Liver International: Official Journal of the International Association for the Study of the Liver
https://www.readbyqxmd.com/read/27782373/efficacy-and-safety-of-sofosbuvir-simeprevir-plus-flat-dose-ribavirin-in-genotype-1-elderly-cirrhotic-patients-a-real-life-study
#19
Adriano M Pellicelli, Valeria Pace Palitti, Pascal Vignally, Francesca Ceccherini-Silberstain, Massimo Siciliano, Valerio Giannelli, Alessandra Moretti, Pierluigi Tarquini, Gaetano Scifo, Vincenzo Messina, Antonio Ascione, Antonio Izzi, Massimo Marignani, Cecilia D'Ambrosio, Lucia Fondacaro, Giuseppe M Ettorre, Pasquale Ialongo, Rodolfo Sacco, Carlo Federico Perno, Giorgio Barbarini
BACKGROUND AND AIMS: The proportion of HCV infected patients over age 65 years in Western countries is increasing. This growth and the advent of new antiviral therapy bring into the question the real world efficacy and safety of the combination of Sofosbuvir (SOF) and Simeprevir (SMV) plus a flat dose of 800 mg/d ribavirin (RBV) in elderly patients with liver cirrhosis compared to younger patients. METHODS: Retrospective observational multicenter real life investigation study of SOF/SMV/RBV for a duration of 12 weeks in HCV genotype 1-infected patients with liver cirrhosis...
October 26, 2016: Liver International: Official Journal of the International Association for the Study of the Liver
https://www.readbyqxmd.com/read/27782364/survival-at-2%C3%A2-years-among-liver-cirrhotic-patients-is-influenced-by-left-atrial-volume-and-left-ventricular-mass
#20
Manuela Merli, Concetta Torromeo, Michela Giusto, Gianna Iacovone, Oliviero Riggio, Paolo E Puddu
BACKGROUND & AIMS: Cirrhotic cardiomyopathy (CC) may interact with the clinical course of cirrhosis and can be implicated in the development of several complications in advanced liver disease. The best and easiest parameters which should define a condition of reduced cardiac reserve in cirrhosis are still controversial. This study was aimed at selecting the cardiac parameters, derived by Doppler echocardiography, predictive of survival during follow-up. METHODS: This study included cirrhotic patients without cardiovascular or pulmonary diseases...
October 26, 2016: Liver International: Official Journal of the International Association for the Study of the Liver
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