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Liver International: Official Journal of the International Association for the Study of the Liver

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https://www.readbyqxmd.com/read/28796410/steatosis-severity-affects-the-diagnostic-performances-of-noninvasive-fibrosis-tests-in-nonalcoholic-fatty-liver-disease
#1
Sae Kyung Joo, Won Kim, Donghee Kim, Jung Ho Kim, Sohee Oh, Kook Lae Lee, Mee Soo Chang, Yong Jin Jung, Young Ho So, Myoung Seok Lee, Jeong Mo Bae, Byeong Gwan Kim
BACKGROUND & AIMS: Nonalcoholic fatty liver disease (NAFLD) includes a wide spectrum of heterogeneous metabolic subtypes. This study compared the diagnostic performances of noninvasive fibrosis tests in predicting advanced fibrosis in patients with NAFLD and examined the effects of the subgroup on their diagnostic performances. METHODS: Three hundred fifteen patients with biopsy-proven NAFLD were prospectively enrolled. Acoustic radiation force impulse imaging (ARFI) was performed to obtain liver stiffness measurements (LSMs)...
August 10, 2017: Liver International: Official Journal of the International Association for the Study of the Liver
https://www.readbyqxmd.com/read/28796371/inflammatory-bowel-disease-with-primary-sclerosing-cholangitis-a-danish-population-based-cohort-study-1977-2011
#2
Jakob Ørskov Sørensen, Ole Haagen Nielsen, Mikael Andersson, Mark Andrew Ainsworth, Henriette Ytting, Erika Bélard, Tine Jess
BACKGROUND AND AIMS: Inflammatory bowel disease (IBD) may be complicated by primary sclerosing cholangitis (PSC). We aimed to assess the characteristics of Danish PSC-IBD patients and to compare their prognosis with IBD patients without PSC. METHODS: A retrospective nationwide population-based cohort of 257 PSC-IBD patients was assessed through Danish national registries and manual scrutiny of patient files. RESULTS: For all PSC-IBD patients diagnosed after 1976 (n=222) and 8,231 IBD controls (i...
August 10, 2017: Liver International: Official Journal of the International Association for the Study of the Liver
https://www.readbyqxmd.com/read/28792652/mutations-in-the-novel-gene-fopv-are-associated-with-familial-autosomal-dominant-and-non-familial-obliterative-portal-venopathy
#3
Claude Besmond, Dominique Valla, Laurence Hubert, Karine Poirier, Brigitte Grosse, Catherine Guettier, Olivier Bernard, Emmanuel Gonzales, Emmanuel Jacquemin
BACKGROUND AND AIMS: Obliterative portal venopathy (OPV) is characterized by lesions of portal vein intrahepatic branches and is thought to be responsible for many cases of portal hypertension in absence of cirrhosis or obstruction of large portal or hepatic veins. In most cases the cause of OPV remains unknown. The aim was to identify a candidate gene of OPV. METHODS: Whole exome sequencing was performed in two families, including 6 patients with OPV. Identified mutations were confirmed by Sanger sequencing and expression of candidate gene transcript was studied by real time qPCR in human tissues...
August 9, 2017: Liver International: Official Journal of the International Association for the Study of the Liver
https://www.readbyqxmd.com/read/28792650/oral-oxycodone-naloxone-for-pain-control-in-liver-cirrhosis-observational-study-in-patients-with-symptomatic-metastatic-hepatocellular-carcinoma
#4
Francesco Tovoli, Stefania De Lorenzo, Boaz Gedaliahu Samolsky Dekel, Fabio Piscaglia, Francesca Benevento, Giovanni Brandi, Luigi Bolondi
BACKGROUND & AIMS: Pain management in liver cirrhosis is a clinical challenge. Most analgesics are metabolized in the liver and cirrhosis may deeply alter their concentration, favoring the appearance of side effects. We aimed to assess the efficacy and safety of oral prolonged-release association of oxycodone/naloxone tablets (OXN) in the treatment of moderate/severe cancer pain in cirrhotic patients with metastatic hepatocellular carcinoma (HCC). METHODS: We enrolled n=32 HCC patients with moderate/severe cancer pain unresponsive to paracetamol alone or associated with codeine or tramadol...
August 9, 2017: Liver International: Official Journal of the International Association for the Study of the Liver
https://www.readbyqxmd.com/read/28792648/mait-cell-frequency-and-function-in-blood-and-liver-of-hcv-mono-and-hcv-hiv-co-infected-patients-with-advanced-fibrosis
#5
Boris J B Beudeker, Gertine W van Oord, Joop E Arends, Julian Schulze Zur Wiesch, Marieke S van der Heide, Robert J de Knegt, Annelies Verbon, Andre Boonstra, Mark A A Claassen
BACKGROUND & AIMS: Mucosal-associated invariant T (MAIT) cells are important innate T-cells with anti-microbial and immunoregulatory activity, recently found to be depleted in blood of patients with HIV and HCV mono-infections. In this study, we assessed the impact of HIV, HCV and HCV/HIV co-infection on circulating and intrahepatic MAIT-cells and correlations with liver fibrosis. METHODS: In this cross-sectional study, 9 healthy subjects, 9 HIV, 20 HCV and 22 HCV/HIV co-infected patients were included...
August 9, 2017: Liver International: Official Journal of the International Association for the Study of the Liver
https://www.readbyqxmd.com/read/28792647/ultrashort-bowel-is-an-independent-risk-factor-for-liver-fibrosis-in-adults-with-home-parenteral-nutrition
#6
Dominique Cazals-Hatem, Lore Billiauws, Pierre-Emmanuel Rautou, Vanessa Bondjemah, Nicolas Pote, Olivier Corcos, Valérie Paradis, Francisca Joly
BACKGROUND & AIMS: Intestinal failure-associated liver disease is rare in adults and risk factors are unclear. The aim of this study was to determine risk factors of liver fibrosis in adults receiving home parenteral nutrition (HPN) for intestinal failure and its impact on survival. METHODS: We retrospectively analyzed patients with irreversible intestinal failure who underwent a liver biopsy between 2000 and 2013. Significant liver fibrosis was defined as ≥F2 according to NASH-CRN score...
August 9, 2017: Liver International: Official Journal of the International Association for the Study of the Liver
https://www.readbyqxmd.com/read/28792643/comments-on-combining-albumin-bilirubin-score-with-future-liver-remnant-predicts-posthepatectomy-liver-failure-in-hbv-associated-hcc-patients
#7
LETTER
Saeid Safiri, Erfan Ayubi
We were interested to read the paper by Zou et al., that was published in the Liver International in Jul 2017 (1). The authors aimed to assess discrimination and predicting power of several scores for postoperative morbidity and posthepatectomy liver failure (PHLF) in Hepatocellular carcinoma (HCC) patients who underwent hepatectomy using area under the curve (AUC) and logistic regression analysis. Their results have demonstrated that Child-Pugh (CP) score (AUC=0.600), the albumin-bilirubin (ALBI) score (AUC=0...
August 9, 2017: Liver International: Official Journal of the International Association for the Study of the Liver
https://www.readbyqxmd.com/read/28782876/portal-vein-thrombosis-after-hepatitis-c-eradication-with-direct-acting-antiviral-therapy
#8
LETTER
Jonathan G Stine, Shaurya Prakash, Patrick G Northup
We read with great interested the recent report of 28 patients by Tripodi et al.(1) suggesting that hepatitis C (HCV) eradication in patients with well compensated cirrhosis may restore the precarious coagulation system back towards a more balanced one by improving individual pro- and anticoagulants and decreasing clotting time. This report confirms previous work by Nielson et al.(2) in the non-cirrhotic population and is timely given the marked clinical benefits obtained by HCV eradication with direct acting antivirals (DAA) and their widespread use...
August 7, 2017: Liver International: Official Journal of the International Association for the Study of the Liver
https://www.readbyqxmd.com/read/28782251/hcv-plays-with-fire-and-yet-avoids-getting-burned-a-review-for-clinicians-on-processing-bodies-and-stress-granules
#9
Carlos Fernández-Carrillo, Gemma Pérez-Vilaró, Juana Díez, Sofía Pérez-Del-Pulgar
Over the last few years, many reports have defined several types of RNA cell granules composed of proteins and messenger RNA (mRNA) that regulate gene expression on a posttranscriptional level. Processing bodies (P-bodies) and stress granules (SGs) are among the best-known RNA granules, only detectable when they accumulate into very dynamic cytosolic foci. Recently, a tight association has been found between positive-stranded RNA viruses, including hepatitis C virus (HCV), and these granules. The present article offers a comprehensive review on the complex and paradoxical relationship between HCV, P-bodies and SGs from a translational perspective...
August 7, 2017: Liver International: Official Journal of the International Association for the Study of the Liver
https://www.readbyqxmd.com/read/28782185/identification-of-hepatitis-c-virus-2k-1b-intergenotypic-recombinants-in-georgia
#10
Mamuka Zakalashvili, Jaba Zarkua, Michael Weizenegger, Jan Bartel, Monika Raabe, Lela Zangurashvili, Nino Kankia, Nino Jashiashvili, Maka Lomidze, Tengiz Telia, Vakhtang Kerashvili, Maia Zhamutashvili, Nikoloz Abramishvili, Charlotte Hedskog, Krishna Chodavarapu, Diana M Brainard, John G McHutchison, Hongmei Mo, Evguenia Svarovskaia, Robert G Gish, Irakli Rtskhiladze, David Metreveli
BACKGROUND AND AIMS: This study aimed to evaluate the prevalence of the hepatitis C virus intergenotype recombinant strain RF1_2k/1b in Georgia, confirm viral recombination by full genome sequencing, and determine a genetic relationship to previously described recombinant hepatitis C viruses. METHODS: We retrospectively analyzed data from 1421 Georgian patients with chronic hepatitis C. Genotyping was performed with the INNO-LiPA VERSANT HCV Genotype 2.0 Assay. RESULTS: Virus isolates were assigned to nonspecific hepatitis C genotypes 2a/2c (n=387) as performed by sequencing of core and NS5B genes...
August 7, 2017: Liver International: Official Journal of the International Association for the Study of the Liver
https://www.readbyqxmd.com/read/28782164/body-temperature-fluctuation-analysis-in-cirrhosis
#11
LETTER
Ali R Mani, Roham Mazloom, Zahra Haddadian, Sara Montagnese
We recently reported that patients with cirrhosis exhibit an abnormal pattern in their skin temperature variability, with complexity analysis of skin temperature fluctuations distinguishing inpatients from outpatients, despite similar mean temperature values [1]. Patients with cirrhosis also exhibit abnormalities in circadian rhythmicity, part of which are of central origin [2]. Therefore, we wondered if abnormalities in skin temperature fluctuations may reflect abnormalities in core body temperature (CBT) regulation in these patients...
August 7, 2017: Liver International: Official Journal of the International Association for the Study of the Liver
https://www.readbyqxmd.com/read/28782153/n-acetylcysteine-and-prednisolone-treatment-improved-serum-biochemistries-in-suspected-flupirtine-cases-of-severe-idiosyncratic-liver-injury
#12
Jürgen Borlak, Florian van Bömmel, Thomas Berg
BACKGROUND & AIMS: The analgesic flupirtine has been linked to cases of severe idiosyncratic drug-induced liver injury (sFILI). We therefore examined whether N-acetylcysteine (NAC) and glucocorticoid therapy is effective in the management of sFILI. METHODS: In a retrospective cohort study efficacy of NAC-infusion and oral prednisolone treatments on liver-function-tests (LFTs) and clinical outcome of 21 sFILI cases was evaluated by comparing it to an external cohort of 30 sFILI cases not receiving the antidote...
August 7, 2017: Liver International: Official Journal of the International Association for the Study of the Liver
https://www.readbyqxmd.com/read/28772348/algorithm-of-golgi-protein-73-and-liver-stiffness-accurately-diagnoses-significant-fibrosis-in-chronic-hbv-infection
#13
Zhujun Cao, Ziqiang Li, Hui Wang, Yuhan Liu, Yumin Xu, Ruidong Mo, Peipei Ren, Lichang Chen, Jie Lu, Hong Li, Yan Zhuang, Yunye Liu, Xiaolin Wang, Gangde Zhao, Weiliang Tang, Xiaogang Xiang, Wei Cai, Longgen Liu, Shisan Bao, Qing Xie
BACKGROUND&AIMS: Serum Golgi protein 73 (GP73) is a potential biomarker for fibrosis assessment. We aimed to develop an algorithm based on GP73 and liver stiffness (LS) for further improvement of accuracy for significant fibrosis in patients with antiviral-naïve chronic hepatitis B virus infection. METHODS: Diagnostic accuracy evaluation of GP73 and development of GP73-LS algorithm was performed in training cohort (n = 267) with an independent cohort (n = 133) for validation...
August 3, 2017: Liver International: Official Journal of the International Association for the Study of the Liver
https://www.readbyqxmd.com/read/28771932/acute-liver-failure-induced-by-idiosyncratic-reaction-to-drugs-challenges-in-diagnosis-and-therapy
#14
Shannan R Tujios, William M Lee
Acute liver failure (ALF) requires urgent attention to identify etiology and determine prognosis, in order to assess likelihood of survival or need for transplantation. Identifying idiosyncratic drug-induced liver injury (iDILI) may be particularly difficult, but the illness generally follows a subacute course, allowing time to assess outcome and find a liver graft if needed. Not all drugs that cause iDILI lead to ALF; the most common are antibiotics including anti-tuberculous medications, non-steroidal anti-inflammatory agents and herbal and dietary supplements (HDS)...
August 3, 2017: Liver International: Official Journal of the International Association for the Study of the Liver
https://www.readbyqxmd.com/read/28756625/sofosbuvir-velpatasvir-in-patients-with-hepatitis-c-virus-genotypes-1-6-and-compensated-cirrhosis-or-advanced-fibrosis
#15
Tarik Asselah, Stefan Bourgeois, Stephen Pianko, Stefan Zeuzem, Mark Sulkowski, Graham R Foster, Lingling Han, John McNally, Anu Osinusi, Diana M Brainard, G Mani Subramanian, Edward J Gane, Jordan J Feld, Alessandra Mangia
BACKGROUND & AIMS: Patients with chronic hepatitis C virus (HCV) infection and advanced fibrosis (Metavir F3) or cirrhosis (Metavir F4) have been identified as a priority group for immediate treatment. We evaluated the safety and efficacy of sofosbuvir-velpatasvir in patients with HCV genotype 1-6 infection and compensated cirrhosis or advanced fibrosis. METHODS: This retrospective analysis included 501 patients with compensated cirrhosis or advanced fibrosis (F3/F4), as defined by >0...
July 30, 2017: Liver International: Official Journal of the International Association for the Study of the Liver
https://www.readbyqxmd.com/read/28752959/genetic-variations-in-toll-like-receptors-7-and-8-modulate-natural-hepatitis-c-outcomes-and-liver-disease-progression
#16
Fatima-Zohra Fakhir, Mustapha Lkhider, Wafaa Badre, Rhimou Alaoui, Eliane F Meurs, Pascal Pineau, Sayeh Ezzikouri, Soumaya Benjelloun
BACKGROUND & AIMS: The natural outcomes of hepatitis C virus (HCV) as well as the progression of the liver disease are highly variable and depend primarily on an efficient immune response. As Toll-like receptors 7 (TLR7) and 8 (TLR8) are important effectors of the innate immunity, the present study aims to evaluate the association between TLR7 and TLR8 polymorphisms and the HCV infection outcomes in Moroccan subjects. METHODS: In this case-control study, 643 subjects including 293 mild chronic hepatitis patients, 119 with advanced liver disease (AdLD), 93 with HCV spontaneous clearance and 138 healthy controls were genotyped using TaqMan SNPs assays...
July 28, 2017: Liver International: Official Journal of the International Association for the Study of the Liver
https://www.readbyqxmd.com/read/28752918/impact-of-hbv-and-s-mansoni-on-portal-pressure-synergy-or-innocent-bystanders
#17
Andrea Lombardi, Patrizia Morbini, Valentina Zuccaro, Raffaele Bruno
A 47-year-old Egyptian patient was seen in our hepatology outpatient clinic for portal hypertension in chronic hepatitis B virus (HBV) infection, HbeAg negative. In consideration of the patient's origin, investigations were undertaken to identify Schistosoma infection. There was a strongly positive serology by ELISA and by indirect hemagglutination test (IHA), whereas microscopic examination of stools and urine did not show Schistosoma eggs. This article is protected by copyright. All rights reserved.
July 28, 2017: Liver International: Official Journal of the International Association for the Study of the Liver
https://www.readbyqxmd.com/read/28746782/cytoplasmic-rods-and-rings-in-mycophenolic-acid-treatment
#18
LETTER
Kan Chen, Buyun Ma, Maikel P Peppelenbosch, Qiuwei Pan
As highlighted in a recent review in Liver International, ribavirin (RBV) retains an important role in the interferon-free era of HCV treatment. In fact, the application of ribavirin has expanded to a broad spectrum of viral infections. One of the most successful examples is the off-label treatment for chronic hepatitis E. This article is protected by copyright. All rights reserved.
July 26, 2017: Liver International: Official Journal of the International Association for the Study of the Liver
https://www.readbyqxmd.com/read/28746779/hepatic-farnesoid-x-receptor-protein-level-and-circulating-fibroblast-growth-factor-19-concentration-in-children-with-nafld
#19
Valerio Nobili, Anna Alisi, Antonella Mosca, Claudia Della Corte, Silvio Veraldi, Rita De Vito, Cristiano De Stefanis, Valentina D'Oria, Joerg Jahnel, Evelyn Zohrer, Eleonora Scorletti, Christopher D Byrne
BACKGROUND & AIMS: Treatment with the farnesoid X receptor (FXR) agonist obeticholic acid is ineffective in some patients with non-alcoholic steatohepatitis (NASH) but the explanation is uncertain. We investigated hepatic FXR expression, and measurements of fibroblast growth factor 19 (FGF19) and bile acids (BAs) in children with NAFLD to investigate relationships with NASH. METHODS: 33 children with NAFLD who underwent diagnostic liver biopsy were studied. Hepatic FXR protein levels and circulating FGF19 concentrations were compared with those analyzed in five control subjects with proven normal liver histology...
July 26, 2017: Liver International: Official Journal of the International Association for the Study of the Liver
https://www.readbyqxmd.com/read/28741901/trends-in-hcv-treatment-uptake-efficacy-and-impact-on-liver-fibrosis-in-the-swiss-hiv-cohort-study
#20
Charles Béguelin, Annatina Suter, Enos Bernasconi, Jan Fehr, Helen Kovari, Heiner C Bucher, Marcel Stoeckle, Mathias Cavassini, Mathieu Rougemont, Patrick Schmid, Gilles Wandeler, Andri Rauch
BACKGROUND & AIMS: Hepatitis C virus (HCV) therapies with interferon-free second-generation direct-acting antiviral agents (DAAs) are highly effective and well tolerated. They have the potential to increase treatment eligibility and efficacy in HIV-infected patients. We assessed the impact of DAAs on treatment uptake, efficacy as well as its impact on the burden of liver disease in the Swiss HIV Cohort Study (SHCS). METHODS: We describe clinical and virological characteristics of patients treated with second generation DAAs...
July 25, 2017: Liver International: Official Journal of the International Association for the Study of the Liver
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