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Liver International: Official Journal of the International Association for the Study of the Liver

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https://www.readbyqxmd.com/read/30230204/long-term-administration-of-human-albumin-improves-survival-in-patients-with-cirrhosis-and-refractory-ascites
#1
Marco Di Pascoli, Silvano Fasolato, Salvatore Piano, Massimo Bolognesi, Paolo Angeli
BACKGROUND AND AIMS: In patients with liver cirrhosis, the clinical benefit of the treatment with human albumin for ascites is debated, and no data are available regarding refractory ascites. In this study, in patients with cirrhosis and refractory ascites, we assessed the effect of long-term albumin administration on emergent hospitalization and mortality. METHODS: Seventy patients with cirrhosis and refractory ascites, followed at the Unit of Internal Medicine and Hepatology, University and General Hospital of Padova, Italy, were included into the study...
September 19, 2018: Liver International: Official Journal of the International Association for the Study of the Liver
https://www.readbyqxmd.com/read/30230194/hepatocellular-carcinoma-in-australia-1982-to-2014-increasing-incidence-and-improving-survival
#2
Michael C Wallace, David B Preen, Mark W Short, Leon A Adams, Gary P Jeffrey
There is a paucity of accurate and current data on HCC trends in incidence and survival in developed countries. We performed an Australia-wide assessment of HCC epidemiology across a 33-year time span aiming to accurately describe changes in incidence and survival METHODS: Cases of HCC from 1982 to 2014 were identified via the Australian Cancer Database (ACD). Trends in incidence rates were explored using piecewise linear regression. Survival was compared by Kaplan-Meier survival curves and 1-, 3- and 5-year survival probabilities by year of diagnosis RESULTS: Age-adjusted HCC incidence rate increased from 1...
September 19, 2018: Liver International: Official Journal of the International Association for the Study of the Liver
https://www.readbyqxmd.com/read/30230192/whole-exome-sequencing-identifies-novel-pathogenic-variants-across-the-atp7b-gene-and-some-modifiers-of-wilson-s-disease-phenotype
#3
Anna Kluska, Maria Kulecka, Tomasz Litwin, Karolina Dziezyc, Aneta Balabas, Magdalena Piatkowska, Agnieszka Paziewska, Michalina Dabrowska, Michal Mikula, Diana Kaminska, Anna Wiernicka, Piotr Socha, Anna Czlonkowska, Jerzy Ostrowski
BACKGROUND & AIMS: Wilson's disease (WD) is an autosomal recessive disorder associated with disease-causing alterations across the ATP7B gene, with highly variable symptoms and age of onset. We aimed to assess whether the clinical variability of WD relates to modifier genes. METHODS: 248 WD patients were included, of whom 148 were diagnosed after age of 17. Human exome libraries were constructed using AmpliSeq technology and sequenced using the IonProton platform...
September 19, 2018: Liver International: Official Journal of the International Association for the Study of the Liver
https://www.readbyqxmd.com/read/30225933/severity-in-polycystic-liver-disease-is-associated-with-etiology-and-female-gender-results-of-the-international-pld-registry
#4
René M M van Aerts, Wietske Kievit, Michiel E de Jong, Curie Ahn, Jesús M Bañales, Jana Reiterová, Frederik Reiterová, Joost P H Drenth
BACKGROUND & AIMS: Polycystic liver disease (PLD) occurs in two genetic disorders, autosomal dominant polycystic kidney disease (ADPKD) and autosomal dominant polycystic liver disease (ADPLD). The aim of this study is to compare disease severity between ADPKD and ADPLD by determining the association between diagnosis and height adjusted total liver volume (hTLV). METHODS: We performed a cross-sectional analysis with hTLV as endpoint. Patients were identified from the International PLD Registry (>10 liver cysts) and included in our analysis when PLD diagnosis was made prior to September 2017, hTLV was available before volume reducing therapy (measured on computed tomography or magnetic resonance imaging) and when patients were tertiary referred...
September 17, 2018: Liver International: Official Journal of the International Association for the Study of the Liver
https://www.readbyqxmd.com/read/30223302/bleeding-after-paracentesis-in-patients-with-decompensated-cirrhosis-and-acute-kidney-injury-the-perfect-storm
#5
LETTER
Edoardo G Giannini, Giorgia Bodini, Manuele Furnari, Elisa Marabotto
We read with great interest the recently published study by Hung and Garcia-Tsao that identified the presence of acute kidney injury (AKI) as the most important predictor of bleeding following paracentesis in patients with decompensated cirrhosis.1 Indeed, although the yield of this study results may be limited by its setting (retrospective, chart review), we feel that the authors should be complimented for their effort in trying to provide a clinical evidence for a pathophysiological hypothesis that was mainly suggested by experts' panel opinions...
September 17, 2018: Liver International: Official Journal of the International Association for the Study of the Liver
https://www.readbyqxmd.com/read/30218633/oatpb1-b3-and-mrp3-expression-in-hepatocellular-adenoma-predicts-gd-eob-dtpa-uptake-and-correlates-with-risk-of-malignancy
#6
Amedeo Sciarra, Sabine Schmidt, Alessandro Pellegrinelli, Marco Maggioni, Daniele Dondossola, Jerome Pasquier, Claudia Cigala, Delfina Tosi, Nermin Halkic, Gaetano Bulfamante, Giuseppe Viale, Silvano Bosari, Charles Balabaud, Paulette Bioulac-Sage, Christine Sempoux
BACKGROUND & AIMS: Hepatobiliary phase (HBP) Gd-EOB-DTPA-enhanced magnetic resonance imaging (MRI) has increased the accuracy in differentiating focal nodular hyperplasia (FNH) and hepatocellular adenoma (HCA). However, the ability of this technique to distinguish HCA subtypes remains controversial. The aim of this study was to investigate the expression of hepatocyte transporters (OATPB1/B3, MRP2, MRP3) in HCA subtypes, hence to understand their MRI signal intensity on HBP Gd-EOB-DTPA-enhanced MRI...
September 15, 2018: Liver International: Official Journal of the International Association for the Study of the Liver
https://www.readbyqxmd.com/read/30218621/extrahepatic-autoimmune-diseases-in-patients-with-autoimmune-hepatitis-and-their-relatives-a-danish-nationwide-cohort-study
#7
Lisbet Grønbaek, Hendrik Vilstrup, Lars Pedersen, Peter Jepsen
BACKGROUND & AIMS: It is widely accepted that patients with autoimmune hepatitis have an increased prevalence of extrahepatic autoimmune diseases. It is believed that the patients' relatives share this trait, but it has not been studied in a satisfactory setting. We conducted a nationwide registry-based cohort study on this issue. METHODS: From Danish healthcare registries 1994-2015 we included 2745 patients with autoimmune hepatitis, 17,812 of their first- and second-degree relatives, and 27,450 general population controls matched with the patients for sex and age...
September 15, 2018: Liver International: Official Journal of the International Association for the Study of the Liver
https://www.readbyqxmd.com/read/30218615/no-clinical-impact-of-hcv-rna-determination-at-the-end-of-treatment-in-patients-receiving-directly-acting-antivirals
#8
LETTER
Vincenzo Craviotto, Laura Lamonaca, Alessio Aghemo, Ana Lleo
We read with interest the article by Maasoumy et al, reporting no clinical impact of detectable HCV RNA at the end of treatment (EOT) visit in patients receiving directly acting antivirals (DAAs) for chronic Hepatitis C (HCV) (1) The authors analyzed 471 HCV genotype 1 (HCV-1) patients who were treated with Sofosbuvir/Ledipasvir and found 7% to be HCV RNA detectable and 3% HCV RNA quantifiable; sustained virological response (SVR) rates in these patients were 97% and 100% respectively. This article is protected by copyright...
September 15, 2018: Liver International: Official Journal of the International Association for the Study of the Liver
https://www.readbyqxmd.com/read/30204306/autoimmune-hepatitis-exerts-a-profound-negative-effect-on-health-related-quality-of-life-a-prospective-single-centre-study
#9
Maciej K Janik, Ewa Wunsch, Joanna Raszeja-Wyszomirska, Maciej Moskwa, Beata Kruk, Marcin Krawczyk, Piotr Milkiewicz
BACKGROUND AND AIMS: Autoimmune hepatitis (AIH) is a progressive chronic liver disease. Health related quality of life (HRQoL) in AIH has not attracted much attention so far. We prospectively assessed various aspects of HRQoL in a well characterized group of patients with AIH. METHODS: In total, 140 patients with AIH (mean age 40±17 years) and 170 controls (mean age 36±14 years) were included. HRQoL was evaluated with following questionnaires: SF-36, Modified-Fatigue Impact Score (MFIS), State-Trait Anxiety Inventory (STAI) and Patient Health Questionnaire-9 (PHQ-9) assessing depression...
September 11, 2018: Liver International: Official Journal of the International Association for the Study of the Liver
https://www.readbyqxmd.com/read/30204289/retrieval-and-cure-of-chronic-hepatitis-c-reach-results-of-micro-elimination-in-the-utrecht-province
#10
Patricia A M Kracht, Joop E Arends, Karel J van Erpecum, Steven F T Thijsen, Bart J M Vlaminckx, Annemarie J L Weersink, Anne M J Wensing, Marjolein P H Deege, Marieke Dimmendaal, Paul H G M Stadhouders, Philip W Friederich, Marc A M T Verhagen, Greet J Boland, Andy I M Hoepelman
BACKGROUND: The Netherlands is one of the six European countries considered on track to eliminate hepatitis C virus (HCV) by 2030. To achieve this goal, continuous efforts have to be put into designing efficient case finding strategies, including the retrieval of previously diagnosed HCV-infected who are lost to follow-up (LFU). AIMS: To trace and treat all LFU HCV patients in the Utrecht region and create an efficient retrieval strategy that can be used in future (national) retrieval initiatives...
September 11, 2018: Liver International: Official Journal of the International Association for the Study of the Liver
https://www.readbyqxmd.com/read/30195258/the-influence-of-drug-properties-and-host-factors-on-delayed-onset-of-symptoms-in-drug-induced-liver-injury
#11
Andres Gonzalez-Jimenez, Kristin McEuen, Minjun Chen, Ayako Suzuki, Mercedes Robles-Diaz, Inmaculada Medina-Caliz, Fernando Bessone, Nelia Hernandez, Marco Arrese, Raymundo Parana, M Isabel Lucena, Camilla Stephens, Raúl J Andrade
BACKGROUND & AIMS: Most patients with drug-induced liver injury (DILI) manifest clinical symptoms while on therapy, while some patients manifest days or weeks after drug cessation (delayed onset). This challenges DILI causality assessment and diagnosis. Factors contributing to the delayed onset phenotype are currently unknown. We explored factors contributing to delayed onset of DILI by analyzing culprit drug properties, host factors and their interactions in a large patient population from the Spanish DILI Registry...
September 8, 2018: Liver International: Official Journal of the International Association for the Study of the Liver
https://www.readbyqxmd.com/read/30188604/positive-familial-history-for-metabolic-traits-predisposes-to-early-and-more-severe-alcoholic-cirrhosis-a-cross-sectional-study
#12
Ajeet Singh Bhadoria, Chandan Kumar Kedarisetty, Chhagan Bihari, Guresh Kumar, Ankur Jindal, Ankit Bhardwaj, Varsha Shasthry, Jaya Benjamin, Manoj Kumar Sharma, Shiv Kumar Sarin
BACKGROUND AND AIM: Familial aggregation of metabolic traits in NAFLD is well documented. However, relevance of these traits in alcoholic cirrhosis is not well studied. We aimed to explore the association of family history of metabolic traits with age at diagnosis, severity and complications of alcoholic cirrhosis. METHODS: In a cross-sectional study, all consecutive patients with alcoholic cirrhosis presenting to our tertiary care centre were included. Family and personal history, demographic characteristics, medical history, anthropometric measurements and laboratory data were recorded...
September 6, 2018: Liver International: Official Journal of the International Association for the Study of the Liver
https://www.readbyqxmd.com/read/30179316/impact-of-dose-and-duration-of-corticosteroid-on-the-risk-of-hepatitis-flare-in-patients-with-chronic-hepatitis-b
#13
Grace Lai-Hung Wong, Becky Wing-Yan Yuen, Henry Lik-Yuen Chan, Yee-Kit Tse, Terry Cheuk-Fung Yip, Kelvin Long-Yan Lam, Grace Chung-Yan Lui, Vincent Wai-Sun Wong
BACKGROUND: Systemic corticosteroid is used for different medical conditions and may cause hepatitis B virus (HBV) reactivation. AIMS: To study the impact of duration and peak dose of corticosteroid on the risk of hepatitis flare in patients with chronic hepatitis B (CHB). METHODS: All patients who received corticosteroid from January 2001 to December 2004 were retrieved from the Hospital Authority, Hong Kong. We stratified patients by daily dose prednisolone equivalents (<20mg, 20-40mg, >40mg) and durations (<7; 7-28; >28 days)...
September 4, 2018: Liver International: Official Journal of the International Association for the Study of the Liver
https://www.readbyqxmd.com/read/30179294/parental-non-alcoholic-fatty-liver-disease-increases-risk-of-non-alcoholic-fatty-liver-disease-in-offspring
#14
Michelle T Long, Ellen B Gurary, Joseph M Massaro, Jiantao Ma, Udo Hoffmann, Raymond T Chung, Emelia J Benjamin, Rohit Loomba
BACKGROUND & AIMS: Little is known regarding the risk of hepatic steatosis (HS) among adult children of affected parents. We examined the association between parental and offspring HS in the multi-generational Framingham Heart Study, which characterized HS using computed tomography. METHODS: We performed multivariable logistic regression models adjusted for age, sex, alcohol use, and body mass index to generate the odds of HS according to parental HS. We determined the proportion of participants with HS according to parental HS and presence or absence of hypertension, diabetes, or obesity (BMI ≥ 30 kg/m2 )...
September 4, 2018: Liver International: Official Journal of the International Association for the Study of the Liver
https://www.readbyqxmd.com/read/30178471/p57-mediated-autophagy-promotes-the-efficacy-of-egfr-inhibitors-in-hepatocellular-carcinoma
#15
Wen-Yuan Li, Qing Li, Li Jing, Tao Wu, Li-Li Han, Yu Wang, Si-Zhe Yu, Ke-Jun Nan, Hui Guo
BACKGROUND & AIMS: Resistance to EGFR-targeted therapy is a major obstacle in hepatocellular carcinoma (HCC) treatment, but its underlying mechanism remains unclear. Autophagy plays a vital role in antitumor treatment. Our previous study suggested that p57 is associated with autophagy and cisplatin resistance. The present study aimed to investigate whether p57 can enhance the sensitivity of HCC cells to Erlotinib (Er) /Cetuximab(C-225) and further explore the potential mechanisms of Er/C-225 resistance...
September 4, 2018: Liver International: Official Journal of the International Association for the Study of the Liver
https://www.readbyqxmd.com/read/30176117/cholangiocarcinoma-in-germany-epidemiological-trends-and-impact-of-misclassification
#16
Dirk Walter, Philip Ferstl, Oliver Waidmann, Jörg Trojan, Sylvia Hartmann, Andreas A Schnitzbauer, Stefan Zeuzem, Klaus Kraywinkel
BACKGROUND & AIMS: Diverging trends of cholangiocarcinoma (CCA) incidence in different countries warrant further subtype-specific characterization. In this study, we aimed to determined current epidemiological trends of CCA in Germany and evaluated impact of misclassification of perihilar CCA (pCCA) as intrahepatic CCA (iCCA). METHODS: Subtype-specific incidence was assessed based on data of approximately 40 million German citizens from 2003-2014 and mortality data of entire Germany were assessed from 1998-2015...
September 3, 2018: Liver International: Official Journal of the International Association for the Study of the Liver
https://www.readbyqxmd.com/read/30176114/relationship-between-nonalcoholic-steatohepatitis-pnpla3-i148m-genotype-and-bone-mineral-density-in-adolescents
#17
Antonella Mosca, Danilo Fintini, Elenora Scorletti, Marco Cappa, Laura Paone, Anna Maria Zicari, Valerio Nobili, Christopher D Byrne
BACKGROUND AND AIMS: It is uncertain whether non-alcoholic steatohepatitis (NASH) is a risk factor for low bone mineral density (BMD). Our aim was to investigate: a) associations between NASH and BMD values and b) associations between PNPLA3 I148M genotypes and BMD, in children with histologically-proven NAFLD. METHODS: BMD area (g/cm2) was measured using dual-energy X-ray absorptiometry (DEXA). NASH was diagnosed by a Steatosis, Activity and Fibrosis (SAF) score and FLIP algorithm...
September 3, 2018: Liver International: Official Journal of the International Association for the Study of the Liver
https://www.readbyqxmd.com/read/30171739/low-prevalence-of-occult-hepatitis-b-virus-infection-in-chronic-hemodialysis-and-kidney-transplant-patients
#18
Marion Muche, Thomas Berg, Sunda Rimpler, Adrienne Staedtler, Stefan Böhm, Peter Nickel, Seema Baid-Agrawal
BACKGROUND: Occult hepatitis B virus infection (OBI) is defined as the presence of hepatitis B virus (HBV)-DNA in serum and/or liver in HBsAg-negative patients. We investigated the prevalence of OBI in large chronic hemodialysis (CHD) and kidney transplant recipients (KTxR) cohorts, including determination of HBV-DNA in peripheral blood mononuclear cells (PBMCs). METHODS: HBV-DNA was determined in both serum and PBMCs in 417 CHD patients, 417 KTxR, 20 HBsAg-positive non-CHD non-KTx patients (positive controls) and 40 HBsAg-negative healthy subjects (negative controls)...
September 1, 2018: Liver International: Official Journal of the International Association for the Study of the Liver
https://www.readbyqxmd.com/read/30160363/paritaprevir-r-ombitasvir-dasabuvir-8-weeks-in-hcv-genotype-1b-with-mild-moderate-fibrosis-results-from-a-real-world-cohort
#19
Marc Puigvehí, Beatriz De Cuenca, Ana Viu, Moisés Diago, Juan Turnes, Francisco Gea, Juan Manuel Pascasio, Sabela Lens, Joaquín Cabezas, Ester Badia, Antonio Olveira, Rosa Maria Morillas, Xavier Torras, Silvia Montoliu, Patricia Cordero, José Luis Castro, Javier Salmerón, Esther Molina, Juan José Sánchez-Ruano, Javier Moreno, María Dolores Antón, José María Moreno, Juan De la Vega, José Luis Calleja, José Antonio Carrión
BACKGROUND & AIMS: The interferon-free regimen paritaprevir/ritonavir, ombitasvir + dasabuvir (PTV/r/OBV/DSV) has shown high efficacy in patients with hepatitis C virus (HCV) genotype 1b infection when administered during 8 or 12 weeks, but data regarding the 8-week treatment is scarce. The aim of our study was to assess the efficacy and safety of the 8-week administration of PTV/r/OBV/DSV in a real-world cohort. METHODS: Multicenter observational study from Spanish Hepa-C database with patients receiving 8 weeks of PTV/r/OBV/DSV (October'16-November'17)...
August 30, 2018: Liver International: Official Journal of the International Association for the Study of the Liver
https://www.readbyqxmd.com/read/30157316/hepatitis-c-elimination-among-people-who-inject-drugs-challenges-and-recommendations-for-action-within-a-health-systems-framework
#20
Emma Day, Margaret Hellard, Carla Treloar, Julie Bruneau, Natasha K Martin, Anne Øvrehus, Olav Dalgard, Andrew Lloyd, John Dillon, Matt Hickman, Jude Byrne, Alain Litwin, Mojca Maticic, Philip Bruggmann, Havard Midgard, Brianna Norton, Stacey Trooskin, Jeffrey V Lazarus, Jason Grebely
The burden of hepatitis C infection is considerable among people who inject drugs (PWID), with an estimated prevalence of greater than 40%, representing an estimated 5.6 million people who have recently injected drugs living with hepatitis C infection. As such, PWID are a priority population for enhancing prevention, testing, linkage to care, treatment and follow-up care in order to meet World Health Organization (WHO) hepatitis C elimination goals by 2030. There are many barriers to enhancing hepatitis C prevention and care among PWID including; poor global coverage of harm reduction services, restrictive drug policies and criminalization of drug use, poor access to health services, low hepatitis C testing, linkage to care and treatment, restrictions for accessing DAA therapy, and the lack of national strategies and government investment to support WHO elimination goals...
August 29, 2018: Liver International: Official Journal of the International Association for the Study of the Liver
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