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Liver International: Official Journal of the International Association for the Study of the Liver

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https://www.readbyqxmd.com/read/28440908/cautious-use-of-platelet-as-a-relevant-inducer-of-liver-regeneration-following-partial-hepatectomy-in-patients-with-metastatic-hepatic-carcinoma
#1
LETTER
Qing Pang, Huichun Liu, Lei Zhou, Hao Jin
The article by Kirschbaum et al. (1) shows that temporary von Willebrand factor-mediated platelet influx in the liver remnant drives platelet-mediated liver regeneration (LR) following partial hepatectomy. Indeed, there is mounting evidence that platelet and endogenous factors are beneficial to hepatocyte regeneration in patients with hepatocellular carcinoma (HCC). Furthermore, platelet-increasing therapy has been recommended to improve LR following partial hepatectomy. However, we want to point out that, platelets may play adverse roles in the remnant liver of HCC and metastatic hepatic carcinoma (MHC) patients...
April 25, 2017: Liver International: Official Journal of the International Association for the Study of the Liver
https://www.readbyqxmd.com/read/28432836/autoimmune-hepatitis-from-current-knowledge-and-clinical-practice-to-future-research-agenda
#2
REVIEW
Marcial Sebode, Johannes Hartl, Diego Vergani, Ansgar W Lohse
Autoimmune hepatitis (AIH) is a chronic inflammatory liver disease. Unknown triggers lead to a mainly T cell-mediated immune response targeting the liver, the main auto-antigen of which has not been identified yet. The diagnosis of AIH is based on the elevation of immunoglobulin G / hypergammaglobulinemia, detection of characteristic autoantibodies as well as a typical pattern on liver histology. Exclusion of other causes of hepatitis and response to immunosuppressive treatment support the diagnosis of AIH...
April 22, 2017: Liver International: Official Journal of the International Association for the Study of the Liver
https://www.readbyqxmd.com/read/28432810/liver-cirrhosis-is-a-risk-factor-for-atrial-fibrillation-a-nationwide-population-based-study
#3
HyunJung Lee, Eue-Keun Choi, Tae-Min Rhee, So-Ryoung Lee, Woo-Hyun Lim, Si-Hyuck Kang, Kyung-Do Han, Myung-Jin Cha, Seil Oh
BACKGROUND & AIMS: Information is lacking regarding whether liver cirrhosis (LC) is associated with atrial fibrillation (AF) development. We aimed to investigate the incidence and clinical significance of AF in cirrhotic patients. METHODS: LC patients (n = 3,596; mean age, 54.7 ± 12.3 years; male, 72.5%) without previous AF were selected from the Korean National Health Insurance Service National Sample Cohort database between 2004 and 2008. Age- and sex-matched controls (n=17,980) were randomly sampled in a 5:1 ratio from non-LC individuals...
April 22, 2017: Liver International: Official Journal of the International Association for the Study of the Liver
https://www.readbyqxmd.com/read/28423231/direct-acting-antiviral-therapy-decreases-hepatocellular-carcinoma-recurrence-rate-in-cirrhotic-patients-with-chronic-hepatitis-c
#4
Victor Virlogeux, Pierre Pradat, Kerstin Hartig-Lavie, François Bailly, Marianne Maynard, Guillaume Ouziel, Domitille Poinsot, Fanny Lebossé, Marie Ecochard, Sylvie Radenne, Samir Benmakhlouf, Joseph Koffi, Philippe Lack, Caroline Scholtes, Anne-Claire Uhres, Christian Ducerf, Jean-Yves Mabrut, Agnès Rode, Massimo Levrero, Christophe Combet, Philippe Merle, Fabien Zoulim
BACKGROUND AND AIMS: Arrival of direct-acting antiviral (DAA) agents against hepatitis C virus (HCV) with high-sustained virological response (SVR) rates and very few side effects has drastically changed the management of HCV infection. The impact of DAA exposure on hepatocellular carcinoma (HCC) recurrence after a first remission in patients with advanced fibrosis remains to be clarified. METHODS: 68 consecutive HCV patients with a first HCC diagnosis and under remission, subsequently treated or not with a DAA combination, were included...
April 19, 2017: Liver International: Official Journal of the International Association for the Study of the Liver
https://www.readbyqxmd.com/read/28423229/profile-and-outcome-of-first-109-cases-of-paediatric-acute-liver-failure-at-a-specialized-paediatric-liver-unit-in-india-methodological-issues
#5
LETTER
Erfan Ayubi, Saeid Safiri
We have meticulously read the article authored by Alam and colleagues published in the journal of Liver International in 2017.(1) The authors purposed to assess the aetiological spectrum and outcome of the paediatric acute liver failure cases. They conducted the study on 109 children with acute liver failure and found that jaundice to encephalopathy interval >7 days (J-E interval >7 days) and higher paediatric/model for end-stage liver disease scores at 72 hours (PELD at 72 h) were associated with poor outcome...
April 19, 2017: Liver International: Official Journal of the International Association for the Study of the Liver
https://www.readbyqxmd.com/read/28418617/improved-survival-of-patients-with-hepatocellular-carcinoma-and-compensated-hcv-related-cirrhosis-who-attained-svr
#6
Savino Bruno, Vito Di Marco, Massimo Iavarone, Luigi Roffi, Vincenzo Boccaccio, Andrea Crosignani, Giuseppe Cabibbo, Sonia Rossi, Vincenza Calvaruso, Alessio Aghemo, Luca Giacomelli, Antonio Craxì, Massimo Colombo, Patrick Maisonneuve
BACKGROUND: Few studies examined the outcome of patients with HCV-related cirrhosis who developed hepatocellular carcinoma (HCC). The relative weight as determinant of death for cancer versus end-stage-liver-disease (ESLD) and the benefit of HCV eradication remain undefined. This multicenter, retrospective analysis evaluates overall survival (OS), rate of decompensation and tumor recurrence in compensated HCC patients treated with IFN according to HCV status since HCC diagnosis. METHODS: Two groups of patients with HCV-related cirrhosis and HCC were followed since HCC diagnosis: (i) compensated cirrhotics with prior sustained virologic response (SVR) on IFN-based regimens (N=19); (ii) compensated cirrhotics without SVR (viremic) (N=156)...
April 18, 2017: Liver International: Official Journal of the International Association for the Study of the Liver
https://www.readbyqxmd.com/read/28418595/validation-of-page-b-model-in-asian-chronic-hepatitis-b-patients-receiving-entecavir-or-tenofovir
#7
Mi Na Kim, Seong Gyu Hwang, Kyu Sung Rim, Beom Kyung Kim, Jun Yong Park, Do Young Kim, Sang Hoon Ahn, Kwang-Hyub Han, Seung Up Kim
BACKGROUND & AIMS: A new hepatocellular carcinoma (HCC) risk prediction model, PAGE-B, which includes age, gender, and platelet count as constituent variables, has recently been proposed in Caucasian chronic hepatitis B (CHB) patients. We validated PAGE-B model and compared its accuracy with that of conventional risk prediction models in Asian CHB patients. METHODS: CHB patients treated with entecavir or tenofovir were consecutively recruited. The performance of PAGE-B and three conventional risk prediction models (CU-HCC, GAG-HCC, and REACH-B) were analyzed...
April 18, 2017: Liver International: Official Journal of the International Association for the Study of the Liver
https://www.readbyqxmd.com/read/28407349/low-l-ficolin-associated-with-disease-severity-during-sepsis-in-adult-icu-patients
#8
LETTER
Ulf Kessler, Luregn J Schlapbach, Peter Klimek, Stephan M Jakob
Foldi et al. reported that L-Ficolin (FCN-2) plasma values were lower in patients with liver cirrhosis compared to healthy adults.(1) In addition low level of FCN-2 was associated with development of significant bacterial infections.(1) However it remains unclear whether low FCN-2 level may be associated to disease severity in infectious diseases. In order to investigate the role of pattern recognition molecules of the lectin complement pathway during sepsis, we assessed plasma levels of MBL, MASP-2, MASP-3, H-Ficolin, and L-Ficolin in a prospective study including 30 adult patients with sepsis requiring admission to our intensive care unit...
April 13, 2017: Liver International: Official Journal of the International Association for the Study of the Liver
https://www.readbyqxmd.com/read/28393476/development-of-predisposition-injury-response-organ-failure-model-for-predicting-acute-kidney-injury-in-acute-on-chronic-liver-failure
#9
Rakhi Maiwall, Shiv Kumar Sarin, Suman Kumar, Priyanka Jain, Guresh Kumar, Ajeet Singh Bhadoria, Richard Moreau, Chandan Kumar Kedarisetty, Zaigham Abbas, Deepak Amarapurkar, Ankit Bhardwaj, Chhagan Bihari, Amna Subhan Butt, Albert Chan, Yogesh Kumar Chawla, Ashok Chowdhury, RadhaKrishan Dhiman, Abdul Kadir Dokmeci, Hasmik Ghazinyan H, Saeed Sadiq Hamid, Dong Joon Kim, Piyawat Komolmit, George K Lau, Guan Huei Lee, Laurentius A Lesmana, Mamun Al-Mahtab, Rajendra Prasad Mathur, Suman Lata Nayak, Qin Ning, Viniyendra Pamecha, Diana Alcantara-Payawal, Archana Rastogi, Salimur Rahman, Mohamed Rela, Vivek A Saraswat, Samir Shah, Gamal Shiha, Barjesh Chander Sharma, Manoj Kumar Sharma, Kapil Sharma, Soek Siam Tan, Shivendra Singh Chandel, Chitranshu Vashishtha, Zeeshan A Wani, Man-Fung Yuen, Osamu Yokosuka
BACKGROUND AND AIM: There is limited data on predictors of acute kidney injury(AKI) in ACLF. We developed a PIRO model (Predisposition, Injury, Response, Organ failure) for predicting AKI in a multi-centric cohort of ACLF patients. PATIENTS AND METHODS: Data of 2360 patients from APASL-ACLF Research Consortium (AARC) was analysed. Multivariate logistic regression model (PIRO score) was developed from a derivation cohort (n=1363) which was validated in another prospective multicentric cohort of ACLF patients (n=997) RESULTS: Factors significant for P component were serum creatinine[(≥2mg/dl)OR 4...
April 10, 2017: Liver International: Official Journal of the International Association for the Study of the Liver
https://www.readbyqxmd.com/read/28393454/whole-liver-engineering-a-promising-approach-to-develop-functional-liver-surrogates
#10
Fanwei Meng, Abdallah Assiri, Dipok Dhar, Dieter Broering
Liver donor shortage remains the biggest challenge for patients with end stage liver failures. While bioartificial liver devices have been developed as temporary supports for patients waiting for transplantation, their applications have been limited clinically. Whole liver engineering is a biological scaffold based regenerative medicine approach that holds promise for developing functional liver surrogates. Significant advancements have been made since the first report in 2010. This review focuses on the recent achievements of whole liver engineering studies...
April 10, 2017: Liver International: Official Journal of the International Association for the Study of the Liver
https://www.readbyqxmd.com/read/28387018/transient-elastography-alone-and-in-combination-with-fibrotest-%C3%A2-for-the-diagnosis-of-hepatic-fibrosis-in-alcoholic-liver-disease
#11
Cosmin Sebastian Voican, Alexandre Louvet, Jean-Baptiste Trabut, Micheline Njiké-Nakseu, Sébastien Dharancy, Andrea Sanchez, Marion Corouge, Karima Lamouri, Amandine Lebrun, Axel Balian, Sophie Prévot, Mounia Lachgar, Sophie Maitre, Hélène Agostini, Philippe Mathurin, Gabriel Perlemuter, Sylvie Naveau
BACKGROUND&AIMS: The reliability of transient elastography (TE) to assess liver fibrosis is insufficiently validated in alcoholic liver disease (ALD). We aimed to validate the diagnostic utility of TE for liver fibrosis in patients with excessive alcohol consumption and evaluate whether Fibrotest(®) adds diagnostic value relative to or in combination with TE. METHODS: We conducted a multicenter prospective study on a total of 217 heavy drinkers with high serum aminotransferase levels...
April 7, 2017: Liver International: Official Journal of the International Association for the Study of the Liver
https://www.readbyqxmd.com/read/28386997/the-transformation-in-biomarker-detection-and-management-of-drug-induced-liver-injury
#12
REVIEW
Rachel J Church, Paul B Watkins
Drug-induced liver injury (DILI) is a major concern for patients, care givers and the pharmaceutical industry. Interpretation of the serum biomarkers routinely used to detect and monitor DILI, which have not changed in almost 50 years, can be improved with recently proposed models employing quantitative systems pharmacology. In addition, several newer serum biomarkers are showing great promise. Studies in rodents indicate that the ratio of the caspase cleaved fragment of cytokeratin 18 to total K18 in serum (termed the "apoptotic index") estimates the relative proportions of apoptosis vs necrosis during drug-induced liver injury...
April 7, 2017: Liver International: Official Journal of the International Association for the Study of the Liver
https://www.readbyqxmd.com/read/28380274/sofosbuvir-based-regimens-against-an-easy-villain-hcv-genotype-2
#13
LETTER
Giuseppe Bruno, Annalisa Saracino, Michele Milella, Gioacchino Angarano
We read with interest the article of Tacke et al. reporting lower sustained virological response (SVR) rates than expected according to clinical trials with a 12 week-course of sofosbuvir (SOF) and ribavirin (RBV) in real-world HCV genotype (GT) 2 infected individuals (1). Conversely, another study demonstrated higher rates of SVR and a good safety profile of this combination (2). This article is protected by copyright. All rights reserved.
April 5, 2017: Liver International: Official Journal of the International Association for the Study of the Liver
https://www.readbyqxmd.com/read/28374906/higher-disappearance-rate-of-anti-hbs-in-taiwanese-freshers-neonatally-vaccinated-with-recombinant-yeast-hepatitis-b-vaccine
#14
Shu-Hua Hsu, An-Hsuan Chih, Yi-Chin Lee, Kuo-Chin Huang, Chyi-Feng Jan
BACKGROUND AND AIM: To compare the long term efficacy of infant recombinant yeast hepatitis B vaccine (Recombinant group) and infant plasma-derived one (Plasma group) in Taiwanese freshers. METHODS: Recruited were a total of 38,377 freshmen who underwent university entrance health examinations from 2003 to 2015. Subjects were assigned into two groups-plasma type and recombinant type, according to the national neonatal hepatitis B immunization program. The seroprevalences of hepatitis B surface antigen, antibody against hepatitis B surface antigen, and antibody against hepatitis B core antigen in each group and gender were calculated...
April 4, 2017: Liver International: Official Journal of the International Association for the Study of the Liver
https://www.readbyqxmd.com/read/28374901/the-impact-of-carbapenem-resistance-on-clinical-deterioration-and-mortality-in-patients-with-liver-disease
#15
Philip G Ferstl, Natalie Filmann, Christian Brandt, Stefan Zeuzem, Michael Hogardt, Volkhard A J Kempf, Mona Müller, Oliver Waidmann, Claudia Reinheimer
BACKGROUND & AIMS: Infections with multidrug-resistant gram-negative bacteria are significantly impairing the prognosis of patients with liver disease. In particular, carbapenem resistance further narrows therapeutic options. This study investigates the impact of carbapenem-resistant gram-negative bacteria on the outcome of patients with liver disease and cirrhosis. METHODS: Between January 2011 and July 2015, 132 patients treated at the tertiary liver transplant center at University Hospital Frankfurt, Germany, were tested positive for carbapenem-resistant gram-negative bacteria and retrospectively analyzed in this study...
April 4, 2017: Liver International: Official Journal of the International Association for the Study of the Liver
https://www.readbyqxmd.com/read/28371239/the-mediterranean-dietary-pattern-as-the-diet-of-choice-for-nafld-evidence-and-plausible-mechanisms
#16
Shira Zelber-Sagi, Federico Salomone, Liat Mlynarsky
Non-alcoholic fatty liver disease (NAFLD) has become a major global health burden, leading to increased risk for cirrhosis, hepatocellular carcinoma, type-2 diabetes and cardiovascular disease. Lifestyle intervention aiming at weight reduction is the most established treatment. However, changing the dietary composition even without weight loss can also reduce steatosis and improve metabolic alterations as insulin resistance and lipid profile. The Mediterranean diet (MD) pattern has been proposed as appropriate for this goal, and was recommended as the diet of choice for the treatment of NAFLD by the EASL-EASD-EASO Clinical Practice Guidelines...
April 2, 2017: Liver International: Official Journal of the International Association for the Study of the Liver
https://www.readbyqxmd.com/read/28371136/mitochondria-targeted-antioxidant-mitoquinone-deactivates-human-and-rat-hsc-and-reduces-portal-hypertension-in-cirrhotic-rats
#17
Marina Vilaseca, Héctor García-Calderó, Erica Lafoz, Maria Ruart, Cristina Isabel López-Sanjurjo, Michael P Murphy, Ramon Deulofeu, Jaume Bosch, Virginia Hernández-Gea, Jordi Gracia-Sancho, Juan Carlos García-Pagán
BACKGROUND & AIMS: In cirrhosis, activated hepatic stellate cells (HSC) play a major role increasing intrahepatic vascular resistance and developing portal hypertension. We have shown that cirrhotic livers have increased reactive oxygen species (ROS), and that antioxidant therapy decreases portal pressure. Considering that mitochondria produce many of these ROS, our aim was to assess the effects of the oral mitochondria-targeted antioxidant mitoquinone on hepatic oxidative stress, HSC phenotype, liver fibrosis and portal hypertension...
April 2, 2017: Liver International: Official Journal of the International Association for the Study of the Liver
https://www.readbyqxmd.com/read/28371374/vitamin-a-deficiency-in-chronic-cholestatic-liver-disease-is-vitamin-a-therapy-beneficial
#18
Cora Freund, Daniel Nils Gotthardt
Chronic cholestatic diseases are progressive diseases of the biliary tract that cause hepatic fibrosis and ultimately lead to liver failure. Liver transplantation is the sole curative option currently available, and because of high morbidity and mortality rates of these diseases, new therapeutic approaches are needed. Vitamin A is a nutrient essential for health as it regulates many processes, including epithelial growth and immunological processes. Vitamin A is primarily stored in hepatic stellate cells, and during liver injury, through an unknown mechanism, these cells lose vitamin A and convert into collagen-producing myofibroblasts, which contributes to hepatic fibrosis...
March 29, 2017: Liver International: Official Journal of the International Association for the Study of the Liver
https://www.readbyqxmd.com/read/28371067/early-liver-transplantation-for-severe-alcoholic-hepatitis-are-we-exploring-all-the-tools
#19
LETTER
Rita Barosa, Cristina Teixeira, João Pinto, D Joana Carvalho E Branco
We read with great interest the review by Toniutto et al.(1) and the debate on liver transplantation (LT) for severe Alcoholic Hepatitis (sAH). In fact, early LT has so far been the only treatment of benefit in strictly selected patients with sAH not responding to medical therapy.(2) Long-term outcomes need to be further assessed and ethical questions must be carefully addressed in both society and medical community, as was elegantly discussed by the authors. This article is protected by copyright. All rights reserved...
March 29, 2017: Liver International: Official Journal of the International Association for the Study of the Liver
https://www.readbyqxmd.com/read/28346737/easl-and-aasld-recommendations-for-the-diagnosis-of-hcc-to-the-test-of-daily-practice
#20
Christophe Aubé, Frederic Oberti, Julie Lonjon, Georges Pageaux, Olivier Seror, Giséle N'Kontchou, Agnes Rode, Sylvie Radenne, Christophe Cassinotto, Julien Vergniol, Ivan Bricault, Vincent Leroy, Maxime Ronot, Laurent Castera, Sophie Michalak, Maxime Esvan, Valérie Vilgrain
AIM: To evaluate the diagnostic performance of CT, MRI, and CEUS alone and in combination, for the diagnosis of HCC between 10 and 30 mm, in a large population of cirrhotic patients. PATIENTS AND METHODS: In a multicentre prospective trial, 442 patients have been enrolled. Within a month CEUS, CT and MRI were performed for all patients. A composite algorithm was defined to obtain the more accurate gold standard. RESULTS: 544 nodules in 381 patients have been retained for the performance analysis...
March 27, 2017: Liver International: Official Journal of the International Association for the Study of the Liver
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