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Liver International: Official Journal of the International Association for the Study of the Liver

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https://www.readbyqxmd.com/read/28921801/complications-symptoms-quality-of-life-and-pregnancy-in-cholestatic-liver-disease
#1
Kais Zakharia, Anilga Tabibian, Keith D Lindor, James H Tabibian
Cholestatic liver diseases (CLDs) encompass a variety of disorders of bile formation and/or flow which generally result in progressive hepatobiliary injury and ultimately end-stage liver disease. Many patients with CLD are diagnosed between the ages of 20-50 years, a particularly productive period of life professionally, biologically, and in other respects; it is not surprising, thus, that CLD is often associated with impaired health-related quality of life (HRQOL) and uncertainty regarding implications for and outcomes of pregnancy...
September 18, 2017: Liver International: Official Journal of the International Association for the Study of the Liver
https://www.readbyqxmd.com/read/28921807/the-italian-compassionate-use-of-sofosbuvir-in-hcv-patients-waitlisted-for-liver-transplantation-a-national-real-life-experience
#2
Silvia Martini, Maria Francesca Donato, Chiara Mazzarelli, Maria Rendina, Ubaldo Visco-Comandini, Daniela Filì, Alice Gianstefani, Stefano Fagiuoli, Mario Melazzini, Simona Montilla, Luca Pani, Sandra Petraglia, Pierluigi Russo, Maria Paola Trotta, Paola Carrai, Paolo Caraceni
BACKGROUND & AIMS: This study aimed to assess the real-life clinical and virological outcomes of HCV waitlisted patients for liver transplantation (LT) who received sofosbuvir/ribavirin (SOF/R) within the Italian compassionate use program. METHODS: Clinical and virological data were collected in 224 patients with decompensated cirrhosis and/or hepatocellular carcinoma (HCC) receiving daily SOF/R until LT or up a maximum of 48 weeks. RESULTS: Of 100 transplanted patients, 51 were HCV-RNA negative for >4 weeks before LT (SVR12: 88%) and 49 negative for <4 weeks or still viremic at transplant: 34 patients continued treatment after LT (bridging therapy) (SVR12: 88%), while 15 stopped treatment (SVR12: 53%)...
September 16, 2017: Liver International: Official Journal of the International Association for the Study of the Liver
https://www.readbyqxmd.com/read/28921803/the-pathophysiology-of-arterial-vasodilatation-and-hyperdynamic-circulation-in-cirrhosis
#3
Søren Møller, Flemming Bendtsen
Patients with cirrhosis and portal hypertension often develop complications from a variety of organ systems leading to a multiple organ failure. The combination of liver failure and portal hypertension result in a hyperdynamic circulatory state partly owing to simultaneous splanchnic and peripheral arterial vasodilatation. Increases in circulatory vasodilators are believed to be due to portosystemic shunting and bacterial translocation leading to redistribution of the blood volume with central hypovolemia. Portal hypertension per se and increased splanchnic blood flow are mainly responsible for the development and perpetuation of the hyperdynamic circulation and the associated changes in cardiovascular function with development of cirrhotic cardiomyopathy, autonomic dysfunction, and renal dysfunction as part of a cardiorenal syndrome...
September 16, 2017: Liver International: Official Journal of the International Association for the Study of the Liver
https://www.readbyqxmd.com/read/28898508/sirt1-mediate-hcv-core-protein-induces-hepatic-steatosis
#4
Chuanhai Zhang, Jingjing Wang, Hanlin Zhang, Shunai Liu, Hyuek Jong Lee, Wanzhu Jin, Jun Cheng
BACKGROUND & AIMS: Hepatic steatosis is a common feature of patients with chronic hepatitis C. Previous reports have shown that the overexpression of HCV core-encoding sequences (hepatitis C virus (HCV) genotypes 3a and 1b) significantly induces intra-cellular triglyceride accumulation. However, the underlying mechanism has not yet been revealed. METHODS: To investigate whether Sirt1 is involved in HCV-mediated hepatic steatosis, the overexpression of HCV core 1b protein and Sirt1 and the knockdown of Sirt1 in HepG2 cells were performed...
September 12, 2017: Liver International: Official Journal of the International Association for the Study of the Liver
https://www.readbyqxmd.com/read/28898507/growth-differentiation-factor-15-predicts-advanced-fibrosis-in-biopsy-proven-non-alcoholic-fatty-liver-disease
#5
Bo Kyung Koo, Sung Hee Um, Dong Soo Seo, Sae Kyung Joo, Jeong Mo Bae, Jeong Hwan Park, Mee Soo Chang, Jung Ho Kim, Jieun Lee, Won-Il Jeong, Won Kim
BACKGROUND & AIMS: We explored whether growth differentiation factor 15 (GDF15) affects the histological severity of non-alcoholic fatty liver disease (NAFLD) independent of insulin resistance. METHODS: In a biopsy-proven NAFLD cohort, we measured serum GDF15 levels using enzyme-linked immunosorbent assays. RESULTS: Among 190 subjects (mean age, 53±14 years; men, 52.1%), 72 (men, 65.3%) and 78 (men, 44.9%) were diagnosed with biopsy-proven non-alcoholic fatty liver (NAFL) and non-alcoholic steatohepatitis (NASH), respectively...
September 12, 2017: Liver International: Official Journal of the International Association for the Study of the Liver
https://www.readbyqxmd.com/read/28887821/serpina1-and-man1b1-polymorphisms-are-not-linked-to-severe-liver-disease-in-a-french-cohort-of-alpha-1-antitrypsin-deficiency-children
#6
Philippe Joly, Alain Lachaux, Mathias Ruiz, Lioara Restier, Abdelhouaed Belmalih, Colette Chapuis-Cellier, Alain Francina, Céline Renoux, Marion Bouchecareilh
BACKGROUND & AIMS: Fifteen to twenty percent of alpha-1 antitrypsin deficiency patients (A1ATD) have a severe liver outcome (portal hypertension - PHT) during childhood. Since they all share the same ZZSERPINA1 genotype and that environmental factors such as alcohol cannot be advanced, the presence of modifier genes is now well recognized. SNPs located on the SERPINA1 and MAN1B1 genes have already been tested in very few studies with contradictory or not replicated results. METHODS: Our genotype-phenotype correlation study, performed on 92 ZZ children, aimed at determining once and for all if SERPINA1 and MAN1B1 polymorphisms may be implied in the onset of PHT...
September 8, 2017: Liver International: Official Journal of the International Association for the Study of the Liver
https://www.readbyqxmd.com/read/28872754/contribution-of-virtual-biopsy-to-the-screening-of-microvascular-invasion-in-hepatocellular-carcinoma-a-pilot-study
#7
Nicolas Poté, François Cauchy, Miguel Albuquerque, Jérôme Cros, Olivier Soubrane, Pierre Bedossa, Valérie Paradis
BACKGROUND & AIMS: Microvascular invasion (mVI) is a major prognostic factor in hepatocellular carcinoma (HCC) that cannot be detected before surgery. Predictive biomarkers of mVI are thus urgently needed. We have developed an original approach of virtual biopsy to assess the performance of an immunohistochemical panel comprising three biomarkers of mVI (H4K16ac, H4K20me2, PIVKA-II) for the prediction of mVI in HCC core needle biopsies (CNB). METHODS: A test set of HCC surgical specimens (n=64) and an independent validation set of HCC CNB (n=42) were constituted...
September 5, 2017: Liver International: Official Journal of the International Association for the Study of the Liver
https://www.readbyqxmd.com/read/28869711/might-sorafenib-combined-with-radiotherapy-be-better-option-for-treating-hepatocellular-carcinoma-with-portal-vein-tumor-thrombosis-pvtt
#8
LETTER
Hao Zhang
Most patients with hepatocellular carcinoma (HCC) are not candidates for traditional curative therapies, since they typically already have advanced disease with extensive local tumors or portal vein tumor thrombosis (PVTT). Recently, Im et al. (1) published a report on a multicenter study investigating the outcomes of radiotherapy in 985 patients with HCC and PVTT. The PVTT response rate was 51.8%, and the median overall survival (OS) time was 10.2 months. This article is protected by copyright. All rights reserved...
September 4, 2017: Liver International: Official Journal of the International Association for the Study of the Liver
https://www.readbyqxmd.com/read/28865179/histopathological-challenges-in-suspected-drug-induced-liver-injury
#9
REVIEW
David E Kleiner
When a patient with suspected drug-induced liver injury (DILI) undergoes liver biopsy, the pathologist is confronted with two major challenges. The first and most important is to establish the pattern(s) of injury which are present. Patterns of injury represent stereotypical responses of an organ to injury and relate to specific etiologies of liver damage. The pattern of injury and the histological details of that injury can then be analyzed with respect to the patient's intercurrent diseases and medication history...
September 2, 2017: Liver International: Official Journal of the International Association for the Study of the Liver
https://www.readbyqxmd.com/read/28865176/feasibility-of-dynamic-risk-prediction-for-hepatocellular-carcinoma-development-in-patients-with-chronic-hepatitis-b
#10
Mi Young Jeon, Hye Won Lee, Seung Up Kim, Beom Kyung Kim, Jun Yong Park, Do Young Kim, Kwang-Hyub Han, Sang Hoon Ahn
BACKGROUND & AIMS: Several risk prediction models for hepatocellular carcinoma (HCC) development are available. We explored whether the use of risk prediction models can dynamically predict HCC development at different time points in chronic hepatitis B (CHB) patients. METHODS: Between 2006 and 2014, 1,397 CHB patients were recruited. All patients underwent serial transient elastography at intervals of >6 months. RESULTS: The median age of the study population (931 males and 466 females) was 49...
September 2, 2017: Liver International: Official Journal of the International Association for the Study of the Liver
https://www.readbyqxmd.com/read/28857411/trajectories-of-serum-hepatitis-b-surface-antigen-kinetics-in-patients-with-chronic-hepatitis-b-receiving-long-term-nucleos-t-ide-analogue-therapy
#11
Wei-Fan Hsu, Chuen-Fei Chen, Hsueh-Chou Lai, Wen-Pang Su, Chia-Hsin Lin, Po-Heng Chuang, Sheng-Hung Chen, Ching-Hsiang Chen, Hung-Wei Wang, Guan-Tarn Huang, Cheng-Yuan Peng
BACKGROUND & AIMS: The kinetics of serum hepatitis B surface antigen (HBsAg) levels during long-term nucleos(t)ide analogue (NA) therapy in chronic hepatitis B (CHB) patients remains unclear. We investigated the patterns of serum HBsAg kinetics and their association with therapeutic outcomes in genotype B- or C-infected CHB patients receiving long-term NA therapy. METHODS: We enrolled 329 treatment-naive CHB patients receiving NA therapy for >5 years to analyse the kinetic patterns by using group-based trajectory models (GBTMs)...
August 31, 2017: Liver International: Official Journal of the International Association for the Study of the Liver
https://www.readbyqxmd.com/read/28853231/treatment-at-a-high-volume-center-is-associated-with-improved-survival-among-patients-with-non-metastatic-hepatocellular-carcinoma
#12
Emma B Holliday, Pamela K Allen, Hesham Elhalawani, Omar Abdel-Rahman
BACKGROUND AND AIMS: The association between case volume and outcomes is well-documented for several cancer types. However, it is unknown if patients with hepatocellular carcinoma treated at high-volume centers have improved overall survival. METHODS: 135,442 patients diagnosed with hepatocellular carcinoma between 2004-2014 were identified in the Commission on Cancer's National Cancer Database. 53,795 patients were excluded for metastatic or node-positive disease...
August 29, 2017: Liver International: Official Journal of the International Association for the Study of the Liver
https://www.readbyqxmd.com/read/28853202/ursodeoxycholic-acid-effects-on-hepatic-unfolded-protein-response-apoptosis-and-oxidative-stress-in-morbidly-obese-patients
#13
Michaela Mueller, Rui E Castro, Anders Thorell, Hanns-Ulrich Marschall, Nicole Auer, Merima Herac, Cecilia M P Rodrigues, Michael Trauner
BACKGROUND AND AIMS: Ursodeoxycholic acid (UDCA) is a secondary hydrophilic bile acid (BA) used as therapy for a range of hepatobiliary diseases. Its efficacy in non-alcoholic fatty liver disease (NAFLD) is still under debate. Here we aimed to decipher molecular mechanisms of UDCA in regulating endoplasmic reticulum (ER) homeostasis, apoptosis and oxidative stress in morbidly obese patients. METHODS: In this randomized controlled pharmacodynamic study, liver and serum samples from 40 well-matched morbidly obese NAFLD-patients were analyzed...
August 29, 2017: Liver International: Official Journal of the International Association for the Study of the Liver
https://www.readbyqxmd.com/read/28853201/author-response-to-letters-to-the-editor-livint-17-00581-cytoplasmic-rods-and-rings-in-ribavirin-treatment-covini-et%C3%A2-al-and-livint-17-00867-cytoplasmic-rods-and-rings-in-mycophenolic-acid-treatment-chen-et-al
#14
LETTER
Jordan J Feld, Jean-Michel Pawlotsky, Fernando Tatsch, Mark Sulkowski, Fred Poordad, Ira Jacobson
We would like to thank Covini and colleagues as well as Chen and colleagues for their interesting comments regarding a recently proposed mechanism for the action of ribavirin. Both groups refer to recent work from Covini and colleagues demonstrating that exposure of cells to ribavirin leads to a rearrangement of the IMPDH enzyme to form rod-like structures termed RR(1) . These RRs have been demonstrated to form in lymphocytes and antibodies targeting them have been noted in patients treated with peginterferon and ribavirin...
August 29, 2017: Liver International: Official Journal of the International Association for the Study of the Liver
https://www.readbyqxmd.com/read/28853199/bacterial-infection-triggered-acute-on-chronic-liver-failure-is-associated-with-increased-mortality
#15
Marcus M Mücke, Tatiana Rumyantseva, Victoria T Mücke, Katharina Schwarzkopf, Sabrina Joshi, Volkhard A J Kempf, Christoph Welsch, Stefan Zeuzem, Christian M Lange
BACKGROUND & AIMS: Acute-on-chronic liver failure (ACLF) is characterized by an acute deterioration of liver function in patients with cirrhosis in combination with recently defined organ failures. Our aim was to independently validate the prognostic value of the recently established EASL-CLIF-Consortium definition of ACLF and to identify new predictors of short-term mortality. METHODS: Patients with cirrhosis and the International Classification of Diseases, Tenth Revision diagnosis of (sub)acute liver failure were retrospectively categorized according to the EASL-CLIF-Consortium definition...
August 29, 2017: Liver International: Official Journal of the International Association for the Study of the Liver
https://www.readbyqxmd.com/read/28853196/a-new-screening-strategy-for-varices-by-liver-and-spleen-stiffness-measurement-lssm-in-cirrhotic-patients-a-randomized-trial
#16
Grace Lai-Hung Wong, Raymond Kwok, Aric Josun Hui, Yee-Kit Tse, Kai-Tin Ho, Angeline Oi-Shan Lo, Kelvin Long-Yan Lam, Heyson Chi-Hey Chan, Rashid Abdul Lui, Kenneth Hon-Da Au, Henry Lik-Yuen Chan, Vincent Wai-Sun Wong
BACKGROUND: Variceal bleeding is a common and life-threatening complication in patients with liver cirrhosis. Screening with upper endoscopy is recommended but is uncomfortable to patients. Non-invasive assessment with transient elastography for liver/spleen stiffness measurement (LSM and SSM) is accurate in detecting varices. AIMS: To test the hypothesis that a new screening strategy for varices guided by LSM/SSM results (LSSM-guided) is non-inferior to universal endoscopic screening in detecting clinically significant varices in patients with cirrhosis...
August 29, 2017: Liver International: Official Journal of the International Association for the Study of the Liver
https://www.readbyqxmd.com/read/28837249/hospital-level-balloon-tamponade-use-is-associated-with-increased-mortality-for-all-patients-presenting-with-acute-variceal-haemorrhage
#17
Elliot B Tapper, Ghideon Ezaz, Vilas Patwardhan, Jessica Mellinger, Alan Bonder, Michael Curry, Sameer D Saini
BACKGROUND & AIMS: Balloon tamponade (BT) can bridge patients to salvage therapy for uncontrollable acute variceal haemorrhage (AVH). However, data are limited regarding the reasons for, rate of and outcomes associated with Balloon tamponade use. METHODS: First, we performed an single-centre cohort study of all patients (N = 139) with oesophageal acute variceal haemorrhage from 01/2009 to 10/2015. Associations between Balloon tamponade use and adherence to four quality metrics (endoscopy within 12 hours, band-ligation, pre-endoscopy antibiotics and octreotide) were evaluated...
August 24, 2017: Liver International: Official Journal of the International Association for the Study of the Liver
https://www.readbyqxmd.com/read/28834649/hepatitis-e-virus-as-a-cause-of-acute-hepatitis-acquired-in-switzerland
#18
Montserrat Fraga, Christopher Doerig, Hervé Moulin, Florian Bihl, Felix Brunner, Beat Müllhaupt, Paolo Ripellino, David Semela, Felix Stickel, Benedetta Terziroli Beretta-Piccoli, Vincent Aubert, Amalio Telenti, Gilbert Greub, Roland Sahli, Darius Moradpour
BACKGROUND: Autochthonous hepatitis E is increasingly recognized as zoonotic infection in western countries. Serologic assays have varying sensitivity and specificity. METHODS: We implemented molecular testing to identify and characterize acute hepatitis E acquired in Switzerland. RESULTS: Ninety-three cases of mostly symptomatic acute hepatitis E acquired in Switzerland were documented by PCR between November 2011 and December 2016. Median HEV RNA was 7...
August 23, 2017: Liver International: Official Journal of the International Association for the Study of the Liver
https://www.readbyqxmd.com/read/28834623/hepatitis-b-virus-hepatitis-d-virus-mother-to-child-co-transmission-a-retrospective-study-in-a-developed-country
#19
Pierre Sellier, Sarah Maylin, Ségolène Brichler, Béatrice Berçot, Amanda Lopes, Dorothée Chopin, Manuela Pogliaghi, Anne-Lise Munier, Véronique Delcey, Guy Simoneau, John Evans, Emmanuel Gordien, François Simon, Jean-François Bergmann
BACKGROUND & AIMS: Hepatitis B Virus (HBV) DNA during chronic infection can reach levels at which mother-to-child (MTC) transmission frequently occurs despite passive-active immunization of newborns. Hepatitis D Virus (HDV) RNA can reach high levels, we assessed HBV/HDV MTC co-transmission. METHODS: Monocentric retrospective study (registered in ClinicalTrials. gov (NCT02044055)), after informed consent in HBV/HDV co-infected women pregnant between 01/01/2004 and 01/01/2015 in Paris, France...
August 23, 2017: Liver International: Official Journal of the International Association for the Study of the Liver
https://www.readbyqxmd.com/read/28834123/pregnancy-outcomes-in-women-with-budd-chiari-syndrome-before-onset-of-symptoms-and-after-treatment
#20
Akash Shukla, Abhishek Sadalage, Deepak Gupta, Amit Gupte, Anupam Mahapatra, Dipendu Mazumder, Chirag Shah, Tejas Modi, Megha Meshram, Prashant Dhore, Shobna Bhatia
BACKGROUND AND AIMS: Pregnancy is known to have poor outcomes in women with Budd Chiari syndrome. There are no data on fertility and pregnancy outcomes prior to onset of symptoms or the effect of therapy on these parameters. We therefore evaluated reproductive profile of women with Budd Chiari Syndrome before the onset of symptoms and after therapy. PATIENTS AND METHODS: Eighty women with Budd Chiari Syndrome (29 years [20-45]) were enrolled over 8 years. Baseline demographic characteristics, disease severity, thrombophilic disorders, and treatment were reviewed...
August 21, 2017: Liver International: Official Journal of the International Association for the Study of the Liver
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