journal
MENU ▼
Read by QxMD icon Read
search

Liver International: Official Journal of the International Association for the Study of the Liver

journal
https://www.readbyqxmd.com/read/28066978/mrecist-to-predict-survival-in-advanced-hcc-analysis-of-two-randomised-phase-ii-trials-comparing-nintedanib-versus-sorafenib
#1
Tim Meyer, Daniel H Palmer, Ann-Lii Cheng, Julia Hocke, Arsène-Bienvenu Loembé, Chia-Jui Yen
BACKGROUND & AIMS: Response Evaluation Criteria in Solid Tumors (RECIST) has been shown to be a poor surrogate for survival benefit with targeted therapy in advanced hepatocellular carcinoma (HCC). METHODS: We investigated whether response evaluated using modified RECIST (mRECIST) predicted overall survival (OS) using data from two Phase II clinical trials. Analyses were conducted on pooled data from 188 patients with advanced HCC treated with nintedanib or sorafenib, of whom 180 were evaluable for response...
January 9, 2017: Liver International: Official Journal of the International Association for the Study of the Liver
https://www.readbyqxmd.com/read/28063180/do-occupational-exposures-to-vinyl-chloride-cause-hepatocellular-carcinoma-and-cirrhosis
#2
Marcello Lotti
Controversy exists about the association between occupational exposures to vinyl chloride and hepatocellular carcinoma and cirrhosis. Two large multicentre mortality cohort studies, one American and another European, reported higher mortality for primary cancer of liver and biliary tract. However, the American study was not able to rule out misclassification, because based on death certificates and under the heading primary liver cancers, some angiosarcomas, the typical neoplasia associated with vinyl chloride, may have been included...
January 7, 2017: Liver International: Official Journal of the International Association for the Study of the Liver
https://www.readbyqxmd.com/read/28061016/a-meta-analysis-of-single-hcv-untreated-arm-of-studies-evaluating-outcomes-after-curative-treatments-of-hcv-related-hepatocellular-carcinoma
#3
Giuseppe Cabibbo, Salvatore Petta, Marco Barbàra, Gabriele Missale, Roberto Virdone, Eugenio Caturelli, Fabio Piscaglia, Filomena Morisco, Antonio Colecchia, Fabio Farinati, Edoardo Giannini, Franco Trevisani, Antonio Craxì, Massimo Colombo, Calogero Cammà
BACKGROUND & AIMS: Determining risk for recurrence or survival after curative resection or ablation in patients with hepatitis C virus (HCV)-related hepatocellular carcinoma (HCC) is important for stratifying patients according to expected outcomes in future studies of adjuvant therapy in the era of direct-acting antivirals (DAAs). The aims of this meta-analysis were to estimate the recurrence and survival probabilities of HCV-related early HCC following complete response after potentially curative treatment and to identify predictors of recurrence and survival...
January 6, 2017: Liver International: Official Journal of the International Association for the Study of the Liver
https://www.readbyqxmd.com/read/28061012/serum-microrna-profiles-as-diagnostic-biomarkers-for-hbv-positive-hepatocellular-carcinoma
#4
Hao-Tu Zhu, Rong-Bin Liu, Ya-Yong Liang, Abdulbaqi M E Hasan, Hai-Yun Wang, Qiong Shao, Zi-Chen Zhang, Jing Wang, Cai-Yun He, Fang Wang, Jian-Yong Shao
BACKGROUND & AIMS: The discovery of effective and reliable biomarkers to detect hepatitis B virus (HBV)-positive hepatocellular carcinoma (HCC) at an early stage may improve the survival of HCC. The aim of this study was to establish serum microRNA (miRNA) profiles as diagnostic biomarkers for HBV-positive HCC. METHODS: We used deep sequencing to screen serum miRNAs in a discovery cohort (n=100). Quantitative polymerase chain reaction (qPCR) assays were then applied to evaluate the expression of selected miRNAs...
January 6, 2017: Liver International: Official Journal of the International Association for the Study of the Liver
https://www.readbyqxmd.com/read/28052486/impact-of-acute-on-chronic-liver-failure-on-90-day-mortality-following-a-first-liver-transplantation
#5
Eric Levesque, Audrey Winter, Zaid Noorah, Jean-Pierre Daurès, Paul Landais, Cyrille Feray, Daniel Azoulay
BACKGROUND: Acute-On-Chronic Liver Failure (ACLF) is associated with a significant short-term mortality rate (23% to 74%), depending on the number of organ failures. Some patients present with ACLF at the time of liver transplantation (LT). The aim of this study was to assess whether ACLF was also a prognostic factor after LT and, if applicable, to construct a score that could predict 90-day mortality. METHODS: Three hundred and fifty cirrhotic patients, who underwent LT between January 2008 and December 2013, were enrolled...
January 4, 2017: Liver International: Official Journal of the International Association for the Study of the Liver
https://www.readbyqxmd.com/read/28028930/an-update-on-cancer-risk-and-surveillance-in-primary-sclerosing-cholangitis
#6
Jennifer L Horsley-Silva, Eduardo A Rodriguez, Diana L Franco, Keith D Lindor
Malignancy represents substantial morbidity and mortality in patients with primary sclerosing cholangitis (PSC). This subset of patients has been proven to be at increased risk for developing cholangiocarcinoma, gallbladder carcinoma, and colorectal cancer in those with overlapping inflammatory bowel disease. Herein we review the prevalence of these malignancies and recommend screening tools and current knowledge to reduce the disease burden in this population. Cholangiocarcinoma is the most dominant malignancy affecting PSC patients, with a lifetime risk ranging from 5-20%...
December 27, 2016: Liver International: Official Journal of the International Association for the Study of the Liver
https://www.readbyqxmd.com/read/28027429/intrahepatic-angiopoietin-2-correlates-with-chronic-hepatitis-c-progression-and-is-induced-in-hcv-replicon-systems
#7
Ángel Hernández-Bartolomé, Rosario López-Rodríguez, Luisa García-Buey, Samuel Martín-Vílchez, Yolanda Rodríguez-Muñoz, María Jesús Borque, Leticia González-Moreno, Yolanda Real-Martínez, Jorge Mendoza-Ridruejo, Elena Martín-Pérez, Ricardo Moreno-Otero, Paloma Sanz-Cameno
INTRODUCTION & AIMS: Chronic hepatitis C (CHC) is a major cause of cirrhosis and hepatocellular carcinoma and angiogenesis is closely related to the pathogenesis and progression of different chronic liver diseases (CLD). Thus, the intrahepatic expression of angiopoietins 1 and 2 (Ang1 and Ang2), as relevant mediators of pathological angiogenesis in several CLD, was investigated. Additionally, the differential influence of structural and non-structural genomic regions of HCV on the expression of angiopoietins and the possible signaling involved were studied...
December 27, 2016: Liver International: Official Journal of the International Association for the Study of the Liver
https://www.readbyqxmd.com/read/28004508/the-molecular-basis-of-jaundice-an-old-symptom-revisited
#8
Silvia Gazzin, Flora Masutti, Libor Vitek, Claudio Tiribelli
Increased serum bilirubin level is a widely used diagnostic marker for hepatic illnesses. Nevertheless, mild elevation of unconjugated serum bilirubin (such as in Gilbert syndrome) has been recently demonstrated to correlate with low risk of chronic pro-inflammatory and/or oxidative stress-mediated diseases. In accord, a low serum bilirubin level has emerged as an important predisposing factor or a biomarker of these pathologic conditions including cardiovascular, tumor, and possibly neurodegenerative diseases...
December 22, 2016: Liver International: Official Journal of the International Association for the Study of the Liver
https://www.readbyqxmd.com/read/27992682/papers-based-on-data-concerning-organs-from-executed-prisoners-should-not-be-published
#9
LETTER
Wendy A Rogers, Maria A Fiatarone Singh, Jacob Lavee
The paper "Safety limitations of fatty liver transplantation can be extended to 40%: Experience of a single centre in China" claims that of the 564 liver transplants performed at the First Affiliated Hospital of Zhejiang University's School of Medicine from April 2010 to October 2014, not a single organ was from an executed prisoner.(1) Unfortunately, it is difficult to see how this claim might be true. There were virtually no voluntary organ transplants in China up until 2010. During the period of the study, more than 90% of all organs for transplantation were from executed prisoners...
December 19, 2016: Liver International: Official Journal of the International Association for the Study of the Liver
https://www.readbyqxmd.com/read/27992681/hepatitis-b-virus-core-related-antigen-as-a-surrogate-marker-for-covalently-closed-circular-dna
#10
Danny Ka-Ho Wong, Wai-Kay Seto, Ka-Shing Cheung, Chun-Kong Chong, Fung-Yu Huang, James Fung, Ching-Lung Lai, Man-Fung Yuen
BACKGROUND & AIMS: Hepatitis B virus (HBV) covalently closed circular DNA (cccDNA) is a key to viral persistence in chronic hepatitis B infection. Serum hepatitis B core-related antigen (HBcrAg) is a novel marker for HBV disease. We aimed to determine whether HBcrAg could be a surrogate marker for intrahepatic cccDNA. METHODS: Three hundred and five liver biopsies and the corresponding sera collected from 138 nucleos(t)ide analogues-treated patients were analyzed...
December 19, 2016: Liver International: Official Journal of the International Association for the Study of the Liver
https://www.readbyqxmd.com/read/27992676/heme-oxygenase-1-polymorphisms-can-affect-hcv-replication-and-treatment-responses-with-different-efficacy-in-humanized-mice
#11
Janine Kah, Tassilo Volz, Marc Lütgehetmann, Anne Groth, Ansgar W Lohse, Gisa Tiegs, Gabriele Sass, Maura Dandri
: Enhancement of host anti-oxidant enzymes, such as heme oxygenase-1, may attenuate virus-mediated hepatocyte injury, while the induction of HO-1 by cobalt-protoporphyrin-IX (CoPP) administration, as the application of its heme degradation product biliverdin (BV), was shown to hinder HCV replication in vitro. Additionally, (GT)n -repeats length in the polymorphic region of the HO-1 promoter may affect HO-1 expression and responsiveness to infection and disease severity. Aim of this study was to investigate the antiviral and hepatoprotective effects of CoPP-mediated HO-1 induction, alone or in combination with interferon alpha (peg-IFNα), in HCV-infected mice harboring hepatocytes from donors with different HO-1-promoter polymorphisms...
December 19, 2016: Liver International: Official Journal of the International Association for the Study of the Liver
https://www.readbyqxmd.com/read/27992664/novel-monitoring-of-hepatitis-b-reactivation-based-on-ultra-high-sensitive-hepatitis-b-surface-antigen-assay
#12
Noboru Shinkai, Shigeru Kusumoto, Shuko Murakami, Shintaro Ogawa, Masaki Ri, Tekeshi Matsui, Akihiro Tamori, Hidenori Toyoda, Takashi Ishida, Shinsuke Iida, Yasuhito Tanaka
BACKGROUND & AIMS: Occult hepatitis B virus (HBV) infection should be evaluated before systemic chemotherapy to prevent HBV reactivation-related hepatitis. We investigated HBV reactivation using high sensitivity HB surface antigen (HBsAg) chemiluminescent enzyme immunoassay (HBsAg-HQ) and ultra-high sensitive HBsAg assay employing a semi-automated immune complex transfer chemiluminescence enzyme technique (ICT-CLEIA). METHODS: Of 120 HBV-resolved patients with hematological malignancy receiving systemic chemotherapy from 2012 to 2015 in our hospital, 13 patients had HBV DNA reactivation (in 12/13 patients HBV DNA became quantifiable) according to HBV DNA monitoring...
December 19, 2016: Liver International: Official Journal of the International Association for the Study of the Liver
https://www.readbyqxmd.com/read/27988985/altered-postural-control-and-stability-in-cirrhotic-patients-with-minimal-hepatic-encephalopathy-correlate-with-cognitive-deficits
#13
Amparo Urios, Alba Mangas-Losada, Carla Gimenez-Garzó, Olga González-López, Remedios Giner-Durán, Miguel A Serra, Enrique Noe, Vicente Felipo, Carmina Montoliu
BACKGROUND & AIMS: Cognitive dysfunction in cirrhotic patients with minimal hepatic encephalopathy (MHE) is associated with falls. Alterations in postural control and stability could contribute to increase falls risk in these patients. We aimed to assess whether postural control and direction-specific limits of stability are altered in cirrhotic patients with MHE compared to patients without MHE and controls. We also assessed if alterations in postural control correlate with neurological impairment and/or blood biomarkers...
December 18, 2016: Liver International: Official Journal of the International Association for the Study of the Liver
https://www.readbyqxmd.com/read/27973711/wisteria-floribunda-agglutinin-positive-human-mac-2-binding-protein-predicts-the-risk-of-hbv-related-liver-cancer-development
#14
Seung Up Kim, Ja Yoon Heo, Beom Kyung Kim, Jun Yong Park, Do Young Kim, Kwang-Hyub Han, Sang Hoon Ahn, Hyon-Suk Kim
BACKGROUND & AIMS: Wisteria floribunda agglutinin-positive human Mac-2 binding protein (WFA(+) -M2BP) can be used to assess the degree of liver fibrosis, but few studies have investigated its prognostic utility. We evaluated whether serum WFA(+) -M2BP can predict the development of hepatocellular carcinoma (HCC) in chronic hepatitis B (CHB) patients. METHODS: A total of 1323 CHB patients with WFA(+) -M2BP test results between 2009 and 2011 were included in this retrospective analysis...
December 14, 2016: Liver International: Official Journal of the International Association for the Study of the Liver
https://www.readbyqxmd.com/read/27966812/hcv-hbv-coinfection-the-dark-side-of-daas-treatment
#15
LETTER
Salvatore Madonia, Emanuele Orlando, Giorgio Madonia, Marco Cannizzaro
No abstract text is available yet for this article.
December 14, 2016: Liver International: Official Journal of the International Association for the Study of the Liver
https://www.readbyqxmd.com/read/27943605/efficacy-and-safety-of-direct-acting-antivirals-based-antiviral-therapies-for-hepatitis-c-virus-patients-with-stage-4-5-chronic-kidney-disease-a-meta-analysis
#16
Tao Li, Yundong Qu, Ying Guo, Yan Wang, Lei Wang
BACKGROUND & AIMS: The aim of this study was to assess the efficacy and safety of direct-acting antivirals (DAA)-based antiviral therapies for HCV patients with stage 4-5 chronic kidney disease. METHODS: We conducted a systematic literature search in PubMed, EMBASE, Web of Science, and CENTRAL on the Cochrane Library without time and language limitations. The search strategy used was "(End stage renal disease OR chronic kidney failure OR severe renal impairment OR chronic kidney disease OR dialysis) AND (sofosbuvir OR simeprevir OR grazoprevir OR elbasvir OR ombitasvir OR paritaprevir OR ritonavir OR dasabuvir OR daclatasvir OR asuparevir OR direct-acting antiviral OR DAA)"...
December 10, 2016: Liver International: Official Journal of the International Association for the Study of the Liver
https://www.readbyqxmd.com/read/27943604/time-trends-in-incidence-and-prognosis-of-hepatocellular-carcinoma-in-denmark-a-nationwide-register-based-cohort-study
#17
Peter Jepsen, Mette W Andersen, Gerda E Villadsen, Peter Ott, Hendrik Vilstrup
BACKGROUND & AIMS: There are no recent data on incidence or survival of hepatocellular carcinoma (HCC) in Denmark. We examined current HCC epidemiology. METHODS: We used data from nationwide registries to identify all Danish citizens diagnosed with HCC in 1994-2016. We computed annual standardized incidence rates for the entire 1994-2016 period, and we compared survival for patients diagnosed in 2004-2014; data on HCC stage were available for that period alone and coded according to the TNM classification...
December 10, 2016: Liver International: Official Journal of the International Association for the Study of the Liver
https://www.readbyqxmd.com/read/27943563/short-duration-treatment-for-chronic-hepatitis-c-virus-with-daclatasvir-asunaprevir-beclabuvir-and-sofosbuvir-fourward-study
#18
Mark S Sulkowski, Steve Flamm, Zeid Kayali, Eric J Lawitz, Paul Kwo, Fiona McPhee, Anne Torbeyns, Eric A Hughes, Eugene S Swenson, Philip D Yin, Misti Linaberry
BACKGROUND AND AIMS: The phase 2, FOURward study (NCT02175966) investigated short-duration therapy (4/6 weeks) with four direct-acting antivirals (DAAs) with distinct mechanisms of action in patients infected with HCV genotype-1. METHODS: Non-cirrhotic patients were randomized 1:1 to DCV-TRIO (fixed-dose daclatasvir 30mg, asunaprevir 200mg and beclabuvir 75mg) twice-daily + sofosbuvir 400 mg once-daily for 4 or 6 weeks. The primary endpoint was sustained virologic response at post-treatment Week 12 (SVR12)...
December 10, 2016: Liver International: Official Journal of the International Association for the Study of the Liver
https://www.readbyqxmd.com/read/27943549/directly-acting-antivirals-combination-for-elderly-patients-with-chronic-hepatitis-c-a-cost-effectiveness-analysis
#19
Antonio Ciaccio, Paolo Angelo Cortesi, Giuseppe Bellelli, Matteo Rota, Sara Conti, Stefano Okolicsanyi, Monica Rota, Giancarlo Cesana, Lorenzo Mantovani Giovanni, Giorgio Annoni, Mario Strazzabosco
BACKGROUND: Chronic Hepatitis C (CHC) has been undertreated among elderly patients. Interferon-free treatment represents an opportunity for these patients. The aim of the study was to assess the cost-effectiveness of Directly Acting Antivirals (DAAs) in CHC elderly patients. METHODS: A Markov model of CHC natural history was built. The study focuses on CHC patients older than 65 years, stratified according to genotype (1/4, 2 and 3), liver fibrosis (METAVIR F1 to F4), age and frailty phenotype (robust, pre-frail and frail)...
December 10, 2016: Liver International: Official Journal of the International Association for the Study of the Liver
https://www.readbyqxmd.com/read/27943509/mushroom-poisoning-an-overlooked-cause-of-acute-liver-injury-in-china
#20
LETTER
Jiawei Geng, Zhengyu Cao, Xiuying Ma, Yingjie Shi, Yi Wang, Qiuwei Pan
No abstract text is available yet for this article.
December 10, 2016: Liver International: Official Journal of the International Association for the Study of the Liver
journal
journal
40341
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"