journal
MENU ▼
Read by QxMD icon Read
search

Liver International: Official Journal of the International Association for the Study of the Liver

journal
https://www.readbyqxmd.com/read/30003672/the-diagnosis-and-management-of-idiosyncratic-drug-induced-liver-injury
#1
Ammar Hassan, Robert J Fontana
Drug induced liver injury (DILI) is an uncommon but important cause of liver disease that can arise after exposure to a multitude of drugs and herbal and dietary supplements. The severity of idiosyncratic DILI varies from mild serum aminotransferase elevations to the development of severe liver injury that can progress to acute liver failure resulting in death or liver transplantation within days of DILI onset. Chronic liver injury that persists for more than 6 months after DILI onset is also becoming increasingly recognized in up to 20% of DILI patients...
July 13, 2018: Liver International: Official Journal of the International Association for the Study of the Liver
https://www.readbyqxmd.com/read/29998565/cost-effectiveness-and-health-related-outcomes-of-screening-for-hepatitis-c-in-korean-population
#2
Kyung-Ah Kim, Wankyo Chung, Hwa Young Choi, Moran Ki, Eun Sun Jang, Sook-Hyang Jeong
BACKGROUND/AIM: In the era of direct-acting antivirals (DAA), active screening for hidden hepatitis C virus (HCV) infection is important for HCV elimination. This study estimated the cost-effectiveness and health-related outcomes of HCV screening and DAA treatment of a targeted population in Korea, where anti-HCV prevalence was 0.6% in 2015. METHODS: A Markov model simulating the natural history of HCV infection was used to examine the cost-effectiveness of 2 strategies: no screening vs...
July 11, 2018: Liver International: Official Journal of the International Association for the Study of the Liver
https://www.readbyqxmd.com/read/29992711/bacterascites-a-study-of-clinical-features-microbiological-findings-and-clinical-significance
#3
Rosalie C Oey, Henk R van Buuren, David M de Jong, Nicole S Erler, Robert A de Man
BACKGROUND: Knowledge about bacterascites is limited and management guidelines are based on small patient series. The purpose of this study was to add further insight into the clinical characteristics, microbiological findings and prognosis of patients diagnosed with bacterascites. METHODS: Retrospective analysis of patients with advanced chronic liver disease diagnosed with bacterascites and SBP between January 2003 and August 2016. RESULTS: In this study, 123 patients were included with 142 episodes of bacterascites...
July 11, 2018: Liver International: Official Journal of the International Association for the Study of the Liver
https://www.readbyqxmd.com/read/29981527/impact-of-hepatocellular-carcinoma-etiology-and-liver-function-on-the-benefit-of-surveillance-a-novel-approach-for-the-adjustment-of-lead-time-bias
#4
Hidenori Toyoda, Takashi Kumada, Toshifumi Tada, Kazuyuki Mizuno, Atsushi Hiraoka, Kunihiko Tsuji, Toru Ishikawa, Tomoyuki Akita, Junko Tanaka
BACKGROUND & AIMS: Surveillance reportedly has benefit on survival in patients with hepatocellular carcinoma (HCC), even after adjustment for lead-time bias. However, previous adjustment for lead-time bias using tumor volume doubling time (TVDT) had inherent problem in accuracy. We evaluated survival benefit of HCC surveillance with newly developed approach for adjusting lead-time bias. In addition, survival benefit was evaluated according to HCC etiology and liver function. METHODS: A total of 3899 patients were studied...
July 7, 2018: Liver International: Official Journal of the International Association for the Study of the Liver
https://www.readbyqxmd.com/read/29981176/territory-wide-population-based-study-of-chronic-hepatitis-c-infection-and-implications-for-hepatitis-elimination-in-hong-kong
#5
Yee Tak Hui, Grace Lai Hung Wong, James Yan Yue Fung, Henry Lik Yuen Chan, Nancy Wai Yee Leung, Sienna Du Liu, Ken Liu, Yiu Keung Ma, David Yiu Kuen But, Wing Yan Mak, Jacky Man Chun Chan, Kin Bon Lai, Ching Kong Loo, Annie Ching Yan Ng, Moon Sing Lai, Chun Wing Chan, Joulen Yue Leung Lau, Tina Tam Ting Fan, Aric Josun Hui, Belsy Chung Yan Lam, Wing I Cheung, Owen Tak Yin Tsang, Karen Lam, Lawrence Siu Wing Lai, Wai Fan Luk, Michael Kin Kong Li, Wai Cheung Lao, Jodis Ting Wa Lam, Steven Woon Choy Tsang, Kam Ngai Kung, Wai Hung Chow, Ronald Kin Nam Tong, Thomas Ka Luen Lui, Edwin Hok Shing Shan, Man Fung Yuen, Vincent Wai Sun Wong
BACKGROUND: To study the epidemiology of chronic hepatitis C virus infection in Hong Kong and to estimate the service gap for achieving the WHO hepatitis elimination targets of attaining a diagnosis rate of 90%, treatment rate of 80% and 65% reduction in mortality rate by 2030. METHODS: From January 2005 to March 2017, patients who were tested positive for anti-HCV were retrospectively retrieved from all public hospitals in Hong Kong. The epidemiological data of 15 participating hospitals were analyzed...
July 7, 2018: Liver International: Official Journal of the International Association for the Study of the Liver
https://www.readbyqxmd.com/read/29979823/role-of-estrogen-and-its-receptors-in-hev-associated-feto-maternal-outcomes
#6
Swati Singh, Mradul Kumar Daga, Ashok Kumar, Syed Akhtar Husain, Premashis Kar
BACKGROUND: Pregnant women infected with HEV develops adverse pregnancy outcomes like, abortions, intrauterine fetal death, still births, neonatal deaths, preterm delivery and maternal mortality. AIM: To correlate estrogen & its receptors ESR1α and ESR2β levels with HEV associated feto-maternal outcomes. MATERIAL & METHODS: A total of 142 pregnant women with HEV infection and 142 pregnant controls were included in study from Department of Obstetrics & Gynaecology and Department of Medicine, Maulana Azad Medical College (MAMC) and associated Lok Nayak Hospital (LNH), New Delhi...
July 6, 2018: Liver International: Official Journal of the International Association for the Study of the Liver
https://www.readbyqxmd.com/read/29962032/early-cirrhosis-and-a-preserved-bone-marrow-niche-favor-regenerative-response-to-growth-factors-in-decompensated-cirrhosis
#7
Lovkesh Anand, Chhagan Bihari, Chandan Kumar Kedarisetty, Sheetalnath B Rooge, Dhananjay Kumar, Smriti Shubham, Guresh Kumar, Amrish Sahney, Manoj Kumar Sharma, Rakhi Maiwall, Anupam Kumar, Shiv Kumar Sarin
BACKGROUND: Exogenous growth factor mobilized Bone Marrow (BM) stem cells has shown a differential response in the management of decompensated cirrhosis (DC). This study was designed to evaluate potential clinical benefit of adding Erythropoietin (EPO) in Granulocyte colony stimulating factor (G-CSF) mobilized stem cell therapy, possible mechanisms of regeneration and predictive factors of regenerative response. METHODS: 60 consecutive DC patients received either G-CSF with EPO (Group A; n=30) or G-CSF and placebo (Group B; n=30) for 2 months and were carefully followed for one year...
July 1, 2018: Liver International: Official Journal of the International Association for the Study of the Liver
https://www.readbyqxmd.com/read/29959866/hepatitis-c-virus-incidence-in-hiv-infected-and-in-preexposure-prophylaxis-prep-using-men-having-sex-with-men
#8
Laurent Cotte, Eric Cua, Jacques Reynes, François Raffi, David Rey, Pierre Delobel, Amandine Gagneux-Brunon, Christine Jacomet, Romain Palich, Hélène Laroche, André Cabie, Bruno Hoen, Christian Chidiac, Pierre Pradat
BACKGROUND & AIMS: HCV incidence still appears on the rise in HIV-infected MSM in France. We assessed the incidence of HCV infection in HIV-positive and in preexposure prophylaxis (PrEP)-using MSM. METHODS: HIV-infected, HCV-negative MSM with serological follow-up in 2016 and HIV-negative, HCV-negative PrEP-using MSM enrolled from January 2016 to May 2017 in the French Dat'AIDS cohort were analyzed to assess the incidence of a primary HCV infection. The incidence of HCV reinfection was also determined in patients having cured a previous infection...
June 30, 2018: Liver International: Official Journal of the International Association for the Study of the Liver
https://www.readbyqxmd.com/read/29956875/metformin-and-risk-of-hepatocellular-carcinoma-in-patients-with-type-2-diabetes
#9
Chin-Hsiao Tseng
BACKGROUND: Whether metformin may reduce hepatocellular carcinoma (HCC) risk requires confirmation. METHODS: Type 2 diabetes patients newly diagnosed during 1999-2005 and with 2 or more prescriptions of antidiabetic drugs were enrolled from the Taiwan's National Health Insurance database. A total of 173 917 ever-users and 21 900 never-users of metformin were identified (unmatched cohort). A 1:1 matched-pair cohort of 21 900 ever-users and 21 900 never-users based on a propensity score (PS) was created...
June 29, 2018: Liver International: Official Journal of the International Association for the Study of the Liver
https://www.readbyqxmd.com/read/29947467/prognostic-factors-of-survival-in-hiv-hcv-co-infected-patients-with-hepatocellular-carcinoma-the-carcinovic-cohort
#10
Moana Gelu-Simeon, Maïté Lewin, Maria Ostos, Tatiana Bayan, Maria Beso Delgado, Elina Teicher, Richard Layese, Françoise Roudot-Thoraval, Hélène Fontaine, Rodolphe Sobesky, Dominique Salmon-Céron, Didier Samuel, Olivier Seror, Pierre Nahon, Laurence Meyer, Jean-Charles Duclos-Vallée
BACKGROUND AND AIMS: HIV/HCV co-infected patients with hepatocellular carcinoma (HCC) have poorer survival than HCV mono-infected patients. We aimed to evaluate the prognostic factors for survival. METHODS: From 2006 to 2013, 55 incident HCCs among HIV+/HCV+ patients, from three ANRS cohorts, were compared with 181 HCCs in HIV-/HCV+ patients from the ANRS Cirvir cohort. RESULTS: HIV+/HCV+ patients were younger (50 years [IQR: 47-53] vs. 62 [54-70], P<0...
June 27, 2018: Liver International: Official Journal of the International Association for the Study of the Liver
https://www.readbyqxmd.com/read/29935104/fatigue-in-chronic-liver-disease-new-insights-and-therapeutic-approaches
#11
Mark G Swain, David E J Jones
The management of fatigue associated with chronic liver disease is a complex and major clinical challenge. Although fatigue can complicate many chronic diseases, it is particularly common in diseases with an inflammatory component. Fatigue can have both peripheral (i.e., neuromuscular) and central (i.e., resulting from changes in neurotransmission within the brain) causes. However, fatigue in chronic liver disease has strong social/contextual components and is often associated with behavioural alterations including depression and anxiety...
June 23, 2018: Liver International: Official Journal of the International Association for the Study of the Liver
https://www.readbyqxmd.com/read/29935102/frailty-in-advanced-liver-disease
#12
Robyn Laube, Hogan Wang, Laura Park, Joanne K Heyman, Helen Vidot, Avik Majumdar, Simone I Strasser, Geoffrey W McCaughan, Ken Liu
Prognostication of patients with cirrhosis is complex, depending on more than just the severity of liver disease. Scores such as the model for end-stage liver disease (MELD) and Child Pugh can assist with prognostication, yet by focusing on physiologic parameters they fail to completely capture the elements contributing to a patient's clinical status. Evidence is increasing to support an important role for physical functioning in patient outcomes. Frailty has been increasingly recognised in medical literature over recent years, including in hepatology where it is identified in nearly half of cirrhosis patients...
June 23, 2018: Liver International: Official Journal of the International Association for the Study of the Liver
https://www.readbyqxmd.com/read/29935100/genetic-polymorphisms-of-the-hepatic-pathways-of-fatty-liver-disease-after-living-donor-liver-transplantation
#13
King-Wah Chiu, Shigeru Goto, Toshiaki Nakano, Tsung-Hui Hu, Ding-Wei Chen, Kuang-Tzu Huang, Li-Wen Hsu, Chao-Long Chen
BACKGROUND & AIMS: Fatty liver disease (FLD) is an important complication associated with liver transplantation, and the cytochrome P-450 system of the donor liver may be involved in its pathogenesis. To explore the effects of the CYP27A1, CYP27B1, CYP2R1, and vitamin D receptor (VDR) pathways on vitamin D maintenance after living donor liver transplantation (LDLT), we investigated the interplay between serum 25(OH)D and common variants in 60 paired donors and recipients who underwent LDLT...
June 23, 2018: Liver International: Official Journal of the International Association for the Study of the Liver
https://www.readbyqxmd.com/read/29935096/should-we-cure-hcv-in-patients-with-hepatocellular-carcinoma-while-treating-cancer
#14
Giuseppe Cabibbo, Ciro Celsa, Calogero Cammà, Antonio Craxì
Direct acting antivirals (DAAs) stabilize or improve liver function in the majority of patients with HCV cirrhosis. Hepatic decompensation is the main driver of death of patients with early, successfully treated HCC superimposed to cirrhosis. Treatment with DAAs could improve the prognosis of these subjects, independently from the subsequent course of HCC, if the efficacy in obtaining viral clearance is as high as in patients without a history of HCC, and if the risk of HCC recurrence is unaffected. When dealing with HCC patients, DAAs can be indicated in two different settings: a) subjects in which HCC has been already successfully treated ("cured" HCC), or b) subjects whose HCC is still untreated or untreatable ("active" HCC)...
June 23, 2018: Liver International: Official Journal of the International Association for the Study of the Liver
https://www.readbyqxmd.com/read/29931819/circulating-levels-of-3-hydroxymyristate-a-direct-quantification-of-endotoxemia-in-non-infected-cirrhotic-patients
#15
Delphine Weil, Jean-Paul Pais de Barros, Guillaume Mourey, Caroline Laheurte, Benoit Cypriani, Nicolas Badet, Eric Delabrousse, Emilie Grandclément, Vincent Di Martino, Philippe Saas, Laurent Lagrost, Thierry Thévenot
BACKGROUND&AIMS: The quantification of lipopolysaccharide (LPS) in biological fluids is challenging. We aimed to measure plasma LPS concentration using a new method of direct quantification of 3-hydroxymyristate (3-HM), a lipid component of LPS, and to evaluate correlations between 3-HM and markers of liver function, endothelial activation, portal hypertension and enterocyte damage. METHODS: Plasma from 90 non-infected cirrhotic patients (30 Child-Pugh [CP]-A, 30 CP-B, 30 CP-C) was prospectively collected...
June 22, 2018: Liver International: Official Journal of the International Association for the Study of the Liver
https://www.readbyqxmd.com/read/29927051/long-term-outcome-in-patients-with-acute-liver-failure
#16
Antonella Putignano, Francesco Figorilli, Eman Alabsawy, Banwari Agarwal, Rajiv Jalan
BACKGROUND AND AIMS: Acute liver failure patients who meet poor prognostic criteria have high early mortality without emergency liver transplantation. A recent study however, reported that patients that survive spontaneously have a poorer outcome compared with patients undergoing transplantation. In this single center study, we aimed to confirm or refute this observation. METHODS: Early survivors (patients who survived 90 days) were assessed for long term outcomes in 4 distinctive cohorts, incorporating aetiology (Acetaminophen overdose or non-Acetaminophen overdose related acute liver failure), and management strategy (conservative or liver transplantation)...
June 21, 2018: Liver International: Official Journal of the International Association for the Study of the Liver
https://www.readbyqxmd.com/read/29901259/the-role-of-mri-and-ercp-in-the-evaluation-of-disease-activity-and-severity-in-primary-sclerosing-cholangitis
#17
Andrea Tenca, Harri Mustonen, Kati Lind, Eila Lantto, Kaija-Leena Kolho, Sonja Boyd, Johanna Arola, Kalle Jokelainen, Martti Färkkilä
BACKGROUND AND AIMS: Endoscopic retrograde cholangiography (ERCP) has been considered the gold standard for the diagnosis and follow-up of primary sclerosing cholangitis, but it has been replaced by less invasive magnetic resonance imaging and cholangio-pancreatography (MRI-MRCP). However, the role of these two techniques in the evaluation of disease activity and severity needs to be elucidated. METHODS: Patients with primary sclerosing cholangitis (n: 48, male 31, median age: 35...
June 14, 2018: Liver International: Official Journal of the International Association for the Study of the Liver
https://www.readbyqxmd.com/read/29900654/forecasting-hepatitis-c-liver-disease-burden-on-real-life-data-does-the-hidden-iceberg-matter-to-reach-the-elimination-goals
#18
Loreta A Kondili, Sarah Robbins, Sarah Blach, Ivane Gamkrelidze, Anna Linda Zignego, Maurizia Rossana Brunetto, Giovanni Raimondo, Gloria Taliani, Andrea Iannone, Francesco Paolo Russo, Teresa Antonia Santantonio, Massimo Zuin, Luchino Chessa, Pierluigi Blanc, Massimo Puoti, Maria Vinci, Elke Maria Erne, Mario Strazzabosco, Marco Massari, Pietro Lampertico, Maria Grazia Rumi, Alessandro Federico, Alessandra Orlandini, Alessia Ciancio, Guglielmo Borgia, Pietro Andreone, Nicola Caporaso, Marcello Persico, Donatella Ieluzzi, Salvatore Madonia, Andrea Gori, Antonio Gasbarrini, Carmine Coppola, Giuseppina Brancaccio, Angelo Andriulli, Maria Giovanna Quaranta, Simona Montilla, Homie Razavi, Mario Melazzini, Stefano Vella, Antonio Craxì
BACKGROUND & AIMS: Advances in direct acting anti-viral treatment of HCV have reinvigorated public health initiatives aimed at identifying affected individuals. We evaluated the possible impact of only diagnosed and linked-to-care individuals on overall HCV burden estimates and identified a possible strategy to achieve the WHO targets by 2030. METHODS: Using a modelling approach grounded in Italian real-life data of diagnosed and treated patients, different linkage-to-care scenarios were built to evaluate potential strategies in achieving the HCV elimination goals...
June 14, 2018: Liver International: Official Journal of the International Association for the Study of the Liver
https://www.readbyqxmd.com/read/29893462/viral-eradication-is-required-for-sustained-improvement-of-patient-reported-outcomes-in-patients-with-hepatitis-c
#19
Zobair M Younossi, Maria Stepanova, Rajender Reddy, Michael P Manns, Marc Bourliere, Stuart C Gordon, Eugene Schiff, Tram Tran, Issah Younossi, Andrei Racila
BACKGROUND: Clearance of chronic HCV infection improves quality of life and other patient-reported outcomes (PROs). Lack of placebo-controlled data led to concerns about the extent of contribution of viral eradication to PRO improvement. AIM: To assess PRO changes in HCV patients initially randomized to placebo treatment who received SOF/VEL/VOX in a deferred treatment substudy. METHODS: HCV-infected direct-acting antivirals-experienced patients who received placebo treatment in POLARIS-1 subsequently received SOF/VEL/VOX (400/100/100 mg) daily for 12 weeks...
June 12, 2018: Liver International: Official Journal of the International Association for the Study of the Liver
https://www.readbyqxmd.com/read/29885038/recurrent-hepatic-mesenchymal-hamartoma-with-osseous-metaplasia
#20
Nur Rahadiani, Marini Stephanie, Juan Putra
No abstract text is available yet for this article.
June 9, 2018: Liver International: Official Journal of the International Association for the Study of the Liver
journal
journal
40341
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"