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Liver International: Official Journal of the International Association for the Study of the Liver

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https://www.readbyqxmd.com/read/28328162/predictive-model-for-inflammation-grades-of-chronic-hepatitis-b-large-scale-analysis-of-clinical-parameters-and-gene-expressions
#1
Weichen Zhou, Yanyun Ma, Jun Zhang, Jingyi Hu, Menghan Zhang, Yi Wang, Yi Li, Lijun Wu, Yida Pan, Yitong Zhang, Xiaonan Zhang, Xinxin Zhang, Zhanqing Zhang, Jiming Zhang, Hai Li, Lungen Lu, Li Jin, Jiucun Wang, Zhenghong Yuan, Jie Liu
BACKGROUND: Liver biopsy is the gold standard to assess pathological features (e.g. inflammation grades) for hepatitis B virus infected patients, although it's invasive and traumatic; meanwhile, several gene profiles of chronic hepatitis B (CHB) have been separately described in relatively small HBV-infected samples. We aimed to analyze correlations among inflammation grades, gene expressions and clinical parameters (serum alanine amino transaminase, aspartate amino transaminase, and HBV-DNA) in large-scale CHB samples, and to predict inflammation grades by using clinical parameters and/or gene expressions...
March 22, 2017: Liver International: Official Journal of the International Association for the Study of the Liver
https://www.readbyqxmd.com/read/28319345/percutaneous-microwave-ablation-of-exophytic-tumors-in-hepatocellular-carcinoma-patients-safe-or-not
#2
Jianmin Ding, Yan Zhou, Yandong Wang, Xiang Jing, Fengmei Wang, Yijun Wang
BACKGROUND & AIMS: To explore the long-term outcomes and safety of ultrasound-guided percutaneous microwave ablation (MWA) of exophytic tumors in hepatocellular carcinoma (HCC) patients. METHODS: One hundred and thirty-two patients with subcapsular HCC were enrolled in this retrospective study. These patients were divided into the exophytic group (n=71) and non-exophytic group (n=61) according to the location of the tumor(s). A special technology of puncture and ablation was performed to treat the exophytic tumors...
March 20, 2017: Liver International: Official Journal of the International Association for the Study of the Liver
https://www.readbyqxmd.com/read/28317318/men-with-biopsy-confirmed-hepatocellular-adenoma-have-a-high-risk-of-progression-to-hcc-a-nationwide-population-based-study
#3
Lars Bossen, Henning Grønbaek, Peter Lykke Eriksen, Peter Jepsen
BACKGROUND: Hepatocellular adenoma is a benign liver tumour that may transform to hepatocellular carcinoma (HCC). We used data from Danish nationwide healthcare registries to investigate the incidence and prognosis of hepatocellular adenoma. METHODS: We included all patients with a hospital discharge diagnosis for benign liver tumour (ICD-10: D13.4) in 1997-2012 and a liver biopsy confirming the hepatocellular adenoma diagnosis. Follow-up began one year after adenoma diagnosis, to minimize the possibility that the tumour was a misdiagnosed HCC...
March 19, 2017: Liver International: Official Journal of the International Association for the Study of the Liver
https://www.readbyqxmd.com/read/28317284/mir-320a-regulates-high-mobility-group-box-1%C3%A2-expression-and-inhibits-invasion-and-metastasis-in-hepatocellular-carcinoma
#4
Guixiang Lv, Mingjuan Wu, Meijie Wang, Xiaochen Jiang, Jingli Du, Kaili Zhang, Dongliang Li, Ning Ma, Yahui Peng, Lujing Wang, Lingyun Zhou, Weiming Zhao, Yufei Jiao, Xu Gao, Zheng Hu
BACKGROUND & AIMS: Several studies have shown that miR-320a induces apoptosis, inhibits cell proliferation, and affects cell cycle progression as a tumor suppressor in many cancers. However, the involvement of miR-320a in the invasion and metastasis of hepatocellular carcinoma (HCC) is still unknown. METHODS: Endogenous miR-320a and high mobility group box 1 (HMGB1) expressions were assayed by real-time PCR. Luciferase activities were measured using a dual-luciferase reporter assay system...
March 19, 2017: Liver International: Official Journal of the International Association for the Study of the Liver
https://www.readbyqxmd.com/read/28296015/constitutional-and-functional-genetics-of-human-alcohol-related-hepatocellular-carcinoma
#5
REVIEW
Pierre Nahon, Jean-Charles Nault
Exploration of the constitutional genetics of hepatocellular carcinoma (HCC) has identified numerous variants associated with a higher risk of liver cancer in alcoholic cirrhotic patients. Although Genome Wide Association studies have not been carried out in the field of alcohol-related HCC, common single nucleotide polymorphisms conferring a small increase in the risk of liver cancer risk been identified and been shown to modulate ethanol metabolism, inflammation, oxidative stress, iron or lipid metabolism...
March 14, 2017: Liver International: Official Journal of the International Association for the Study of the Liver
https://www.readbyqxmd.com/read/28294520/bidimensional-shear-wave-ultrasound-elastography-with-supersonic-imaging-to-predict-presence-of-esophageal-varices-in-cirrhosis
#6
LETTER
Horia Stefanescu, Giulia Allegretti, Veronica Salvatore, Fabio Piscaglia
We read with great interest the manuscript by Jansen et.al (1), recently published in Liver International. In keeping with their findings, we also hold liver and spleen elastography (L/S-2D-SWE) as important tools for the non-invasive assessment of cirrhotic patients. In their work, Jansen (1) did not assess the prediction of complications of CSPH, like presence of esophageal varices (EV). The Baveno VI consensus states that EV may be ruled-out when liver stiffness (measured by transient elastography) is <20KPa and concurrently platelet (PLT) count >150x10(3) /ml (2)...
March 14, 2017: Liver International: Official Journal of the International Association for the Study of the Liver
https://www.readbyqxmd.com/read/28296080/non-invasive-fibrosis-markers-for-chronic-hepatitis-b-in-sub-saharan-africa
#7
LETTER
Rui Huang, Bei Jia, Guiyang Wang, Chao Wu
We read with great interest the article by Desalegn H et al (1), in which they determined the potential diagnostic accuracy of aspartate aminotransferase to platelet ratio index (APRI), fibrosis-4 score (FIB-4) and gamma-glutamyl transpeptidase to platelet ratio (GPR) in one of the largest chronic hepatitis B (CHB) cohorts in sub-Saharan Africa (1). They concluded that APRI, FIB-4 and GPR were valuable for the diagnosis of liver fibrosis and cirrhosis in CHB patients in sub-Saharan Africa (1). However, the sensitivity for detecting fibrosis and cirrhosis was relatively low (1) This article is protected by copyright...
March 13, 2017: Liver International: Official Journal of the International Association for the Study of the Liver
https://www.readbyqxmd.com/read/28296013/long-term-outcome-of-inactive-and-active-low-viremic-hbeag-negative-hepatitis-b-virus-infection-benign-course-towards-hbsag-clearance
#8
Filippo Oliveri, Lidia Surace, Daniela Cavallone, Piero Colombatto, Gabriele Ricco, Nicola Salvati, Barbara Coco, Veronica Romagnoli, Riccardo Gattai, Antonio Salvati, Francesco Moriconi, Quan Yuan, Ferruccio Bonino, Maurizia Rossana Brunetto
BACKGROUND/AIM: The difference between the long-term outcome of low-viremic (HBV-DNA≤20,000-IU/mL, LV-AC) and inactive HBsAg carriers (HBV-DNA≤2,000-IU/mL, IC) remains to be defined. We studied prospectively 153 HBeAg-negative HBsAg-carriers with baseline HBV-DNA≤20,000-IU/mL and normal transaminases. METHODS: IC, LV-AC or chronic hepatitis B (CHB) (HBV-DNA persistently ≤2,000-IU/mL, ≤20,000-IU/mL or >20,000-IU/mL, respectively) were diagnosed after 1-year, 3-monthly monitoring...
March 13, 2017: Liver International: Official Journal of the International Association for the Study of the Liver
https://www.readbyqxmd.com/read/28294515/clinical-risk-scoring-for-predicting-non-alcoholic-fatty-liver-disease-in-metabolic-syndrome-patients-nafld-ms-score
#9
Surasak Saokaew, Shada Kanchanasuwan, Piyaporn Apisarnthanarak, Aphinya Charoensak, Phunchai Charatcharoenwitthaya, Pochamana Phisalprapa, Nathorn Chaiyakunapruk
BACKGROUND & AIMS: Non-alcoholic fatty liver disease (NAFLD) can progress from simple steatosis to hepatocellular carcinoma. None of tools has been developed specifically for high-risk patients. This study aimed to develop a simple risk scoring to predict NAFLD in patients with metabolic syndrome (MetS). METHODS: A total of 509 patients with MetS were recruited. All were diagnosed by clinicians with ultrasonography-confirmed whether they were patients with NAFLD...
March 12, 2017: Liver International: Official Journal of the International Association for the Study of the Liver
https://www.readbyqxmd.com/read/28294511/ugt1a-polymorphisms-as-genetic-biomarkers-for-hcc-risk-in-caucasian-population
#10
Elena De Mattia, Erika Cecchin, Jerry Polesel, Francesco Lupo, Claudio Tiribelli, Marina Crovatto, Angela Buonadonna, Giuseppe Toffoli
BACKGROUND&AIMS: The definition of new biomarkers of hepatocellular carcinoma (HCC) risk, especially in high-risk HBV/HCV-positive population, is urgently needed to improve HCC clinical management. This study focused on variants of UDP-glucuronosyltransferase 1A (UGT1A) enzymes, that catalyse the reaction of glucuronidation, one of the most important chemical defence pathway of the body. Aim of the study was to elucidate the contribution of UGT1A polymorphisms in predicting HCC susceptibility in Caucasians...
March 12, 2017: Liver International: Official Journal of the International Association for the Study of the Liver
https://www.readbyqxmd.com/read/28296047/non-selective-beta-blockers-are-not-associated-with-increased-mortality-in-cirrhotic-patients-with-ascites
#11
Simona Onali, Maria Kalafateli, Avik Majumdar, Rachel Westbrook, James O'Beirne, Gioacchino Leandro, David Patch, Emmanuel A Tsochatzis
BACKGROUND & AIMS: Controversy exists on the impact of non-selective beta-blockers (NSBBs) on survival in patients with ascites. We assessed whether NSBB treatment affects survival in a cohort of 316 consecutive patients with ascites undergoing evaluation for liver transplantation. METHODS: Consecutive patients with cirrhosis and ascites assessed for liver transplantation between 2011-2014 were retrospectively evaluated. Cox regression and competing risk analysis were performed to identify predictors of survival...
March 11, 2017: Liver International: Official Journal of the International Association for the Study of the Liver
https://www.readbyqxmd.com/read/28276137/binge-drinking-and-the-risk-of-liver-events-a-population-based-cohort-study
#12
Fredrik Åberg, Jaana Helenius-Hietala, Pauli Puukka, Antti Jula
BACKGROUND & AIMS: Binge drinking or heavy episodic drinking is increasingly prevalent, but the health effects are incompletely understood. We investigated whether binge drinking increases the risk for liver disease above the risk due to average alcohol consumption. METHODS: 6366 subjects without baseline liver disease who participated in the Finnish population-based Health 2000 Study (2000-2001), a nationally representative cohort. Follow-up data from national registers until 2013 were analysed for liver-related admissions, mortality, and liver cancer...
March 9, 2017: Liver International: Official Journal of the International Association for the Study of the Liver
https://www.readbyqxmd.com/read/28267889/the-role-of-platelets-on-regenerating-liver-thoughts-beyond-parenchymal-proliferation
#13
LETTER
Demetrios Moris, Dimitrios Dimitroulis, Michael Kontos, Timothy M Pawlik
Kirschbaum et al.reported that liver regeneration after partial hepatectomy was lower among patients with thrombocytopenia compared with patients with normal platelet(PLT) count.(1)In addition, PLT influx into the remnant liver was virtually absent in the presence of von Willebrand factor(VWF)antibody, suggesting that VWF release from liver sinusoidal endothelial cells(LSEC)may mediate platelet influx.(1)While the study offered several new insights into the role that platelets may play in liver regeneration, several points warrant further consideration...
March 7, 2017: Liver International: Official Journal of the International Association for the Study of the Liver
https://www.readbyqxmd.com/read/28267888/role-of-hla-dp-and-hla-dq-on-the-clearance-of-hepatitis-b-virus-and-the-risk-of-chronic-infection-in-a-multiethnic-population
#14
Julieta Trinks, Nao Nishida, María Laura Hulaniuk, Mariela Caputo, Takayo Tsuchiura, Sebastián Marciano, Leila Haddad, Jorgelina Blejer, Sonia Bartoli, Beatriz Ameigeiras, Silvia E Frías, Cecilia Vistarini, Fabiana Heinrich, Carlos Remondegui, Susana Ceballos, Gustavo Echenique, Miguel Charre Samman, Claudia D'Amico, Amalia Rojas, Alfredo Martínez, Ezequiel Ridruejo, Roberto J Fernández, Leandro Burgos Pratx, Horacio Salamone, Félix Nuñez, Omar Galdame, Adrián Gadano, Daniel Corach, Masaya Sugiyama, Diego Flichman, Katsushi Tokunaga, Masashi Mizokami
BACKGROUND & AIMS: HBV infection exhibits geographical variation in its distribution in South America. While HBV rates are low in Central Argentina, the North-western region exhibits intermediate HBV rates. Unfortunately, the reasons that could explain this difference are still unknown. METHODS: 1440 Argentines were recruited and grouped into HBV patients, HBV resolved individuals and healthy controls. Genetic ancestry was assessed by analysis of bi-parental lineages and ancestry autosomal typing...
March 7, 2017: Liver International: Official Journal of the International Association for the Study of the Liver
https://www.readbyqxmd.com/read/28267887/enhanced-liver-fibrosis-test-predicts-transplant-free-survival-in-primary-sclerosing-cholangitis-a-multi-center-study
#15
Elisabeth M G de Vries, Martti Färkkilä, Piotr Milkiewicz, Johannes R Hov, Bertus Eksteen, Douglas Thorburn, Olivier Chazouillères, Albert Pares, Ståle Nygård, Odd Helge Gilja, Ewa Wunsch, Pietro Invernizzi, Marco Carbone, Francesca Bernuzzi, Kirsten Muri Boberg, Helge Røsjø, William Rosenberg, Ulrich H Beuers, Cyriel Y Ponsioen, Tom H Karlsen, Mette Vesterhus
BACKGROUND AND AIMS: Biomarkers reflecting disease activity and prognosis in primary sclerosing cholangitis (PSC) have not been firmly established. Enhanced Liver Fibrosis (ELF) test was previously reported to predict outcome in PSC. We aimed to validate the prognostic utility of ELF test in an independent, multicenter, retrospective PSC study population. METHODS: We collected serum samples from PSC patients from seven countries. We estimated rates of transplant-free survival by the Kaplan-Meier method, used Cox proportional hazards regression to explore the association between ELF test and clinical outcome and determined prognostic performance of ELF test by computing the area under the receiver operating characteristic (AUC-ROC) curve...
March 7, 2017: Liver International: Official Journal of the International Association for the Study of the Liver
https://www.readbyqxmd.com/read/28267886/primary-non-function-is-frequently-associated-with-fatty-liver-allografts-and-high-mortality-after-re-transplantation
#16
Ulf Kulik, Frank Lehner, Jürgen Klempnauer, Jürgen Borlak
BACKGROUND & AIMS: The shortage of liver donations demands the use of suboptimal grafts with steatosis being a frequent finding. Although ≤30% macrovesicular steatosis is considered to be safe the risk for primary non-function (PNF) and outcome after re-transplantation (re-OLT) is unknown. METHODS: Among 1205 orthotropic liver transplantations performed at our institution the frequency, survival and reason of re-OLT was evaluated. PNF (group A) cases and those with initial transplant function but subsequent need for re-OLT (group B) were analyzed...
March 7, 2017: Liver International: Official Journal of the International Association for the Study of the Liver
https://www.readbyqxmd.com/read/28267885/portal-vein-thrombosis-occurrence-in-a-cirrhotic-patient-during-treatment-with-rivaroxaban
#17
LETTER
Francesca Romana Ponziani, Erica De Candia, Raimondo De Cristofaro, Maurizio Pompili
De Gottardi et al.(1) have reported a safe use of direct oral anticoagulants (DOACs) in patients with splanchnic vein thrombosis with or without liver cirrhosis. A few cases of portal vein thrombosis (PVT) resolution in cirrhotic patients after treatment with DOACs have been reported to date, whereas their efficacy in the prevention of PVT has not been investigated yet. We have recently observed a case of PVT occurred in a 81 year-old woman with cryptogenic liver cirrhosis, Child-Pugh score B8, under treatment with the DOAC rivaroxaban 20 mg daily for chronic atrial fibrillation...
March 7, 2017: Liver International: Official Journal of the International Association for the Study of the Liver
https://www.readbyqxmd.com/read/28261910/a-systematic-review-and-meta-analysis-of-hcv-clearance
#18
REVIEW
Emeline Gauthiez, Ines Habfast-Robertson, Sina Rüeger, Zoltan Kutalik, Vincent Aubert, Thomas Berg, Andreas Cerny, Meri Gorgievski, Jacob George, Markus H Heim, Raffaele Malinverni, Darius Moradpour, Beat Müllhaupt, Francesco Negro, David Semela, Nasser Semmo, Jean Villard, Stéphanie Bibert, Pierre-Yves Bochud
BACKGROUND & AIMS: While hepatitis C exemplifies the role of host genetics in infectious diseases outcomes, there is no comprehensive overview of polymorphisms influencing spontaneous and/or treatment-induced HCV clearance. We performed a systematic review and meta-analysis of host polymorphisms associated with these phenotypes. METHODS: Litterature search was conducted by using combinations of keywords in 3 databases. Studies were reviewed and relevant data systematically extracted for subsequent meta-analyses...
March 6, 2017: Liver International: Official Journal of the International Association for the Study of the Liver
https://www.readbyqxmd.com/read/28247572/long-term-outcome-of-chronic-hepatitis-c-chc-virus-infection-in-a-real-world-setting-the-german-lotos-study
#19
Heiner Wedemeyer, Jens Reimer, Petra Sandow, Dietrich Hueppe, Thomas Lutz, Kurt Gruengreiff, Joerg Goelz, Stefan Christensen, Heike Pfeiffer-Vornkahl, Ulrich Alshuth, Michael P Manns
BACKGROUND & AIMS: There are few large-scale, prospective studies comparing liver-associated events in treated and untreated patients with CHC managed in routine clinical practice. METHODS: Patients with CHC were prospectively enrolled in a non-interventional study. Data from patients with available documentation who had either achieved a sustained virological response, or were non-responders, relapsers, or had virological breakthrough following treatment with peginterferon alfa-2a ± ribavirin, or who had been diagnosed but never treated at least 3 years previously, and who remained under medical observation were analyzed...
March 1, 2017: Liver International: Official Journal of the International Association for the Study of the Liver
https://www.readbyqxmd.com/read/28241398/prothrombin-complex-concentrate-to-correct-acquired-abnormalities-of-the-clotting-screen-in-patients-with-liver-impairment
#20
LETTER
Martin Scott, Roxanne Ramsay, Charles R M Hay, Jecko Thachil
We respond to Desborough et al and the accompanying editorial [1,2]. It is clear, even from the audit parameters set by the authors, that the current understanding of coagulation abnormalities in cirrhosis has not found widespread translation into clinical practice. The standards set for fresh frozen plasma (FFP) transfusion follow guidelines developed by the Cardiovascular and Interventional Radiological Society of Europe but, for reasons discussed in the editorial, it is not clear if these parameters are relevant in cirrhotic patients...
February 27, 2017: Liver International: Official Journal of the International Association for the Study of the Liver
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