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Liver International: Official Journal of the International Association for the Study of the Liver

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https://www.readbyqxmd.com/read/28632958/decreased-portal-vein-velocity-is-predictive-of-the-development-of-portal-vein-thrombosis-a-matched-case-control-study
#1
Jonathan G Stine, Jennifer Wang, Puja M Shah, Curtis K Argo, Nicolas Intagliata, Andre Uflacker, Stephen H Caldwell, Patrick G Northup
BACKGROUND & AIMS: Portal vein thrombosis (PVT) in cirrhosis may lead to hepatic decompensation and increased mortality. We aimed to investigate if decreased portal vein (PV) velocity is associated with future PVT. METHODS: Data on adult patients with cirrhosis and PVT between January 1, 2005 and July 30, 2015 were obtained. Cases with PVT were matched by age, gender and Model for End stage Liver Disease (MELD) score to corresponding controls without PVT. Cox proportional hazards models, receiver operator curves and Kaplan Meier curves were constructed...
June 20, 2017: Liver International: Official Journal of the International Association for the Study of the Liver
https://www.readbyqxmd.com/read/28632324/reply-to-external-validation-of-the-donor-risk-index-and-the-eurotransplant-donor-risk-index-on-the-french-liver-transplantation-registry
#2
LETTER
Joris J Blok, Hein Putter, Jacob D de Boer, Andries E Braat
With interest we read the recent publication by Winter et al. [1] In their publication the authors describe the inability to validate the donor risk index (DRI) [2] and Eurotransplant donor risk index (ET-DRI) [3] with data from the French liver transplant (LT) registry. The intention of the authors to validate the DRI/ET-DRI for use as an indicator of donor risk and subsequently to improve matching between liver donors and LT recipients is relevant and important. This article is protected by copyright. All rights reserved...
June 20, 2017: Liver International: Official Journal of the International Association for the Study of the Liver
https://www.readbyqxmd.com/read/28627094/-spectrum-of-hepatitis-b-and-renal-involvement
#3
Apurva S Shah, Deepak N Amarapurkar
Renal involvement in hepatitis B occurs in various spectrums and its knowledge is important for clinicians in management of patients. The renal diseases most commonly associated with hepatitis B virus (HBV) infection include membranous nephropathy, membranoproliferative glomerulonephritis, and Polyarteritis nodosa. The widespread use of hepatitis B vaccination has decreased the incidence of HBV-related renal diseases. The incidence of HBV infection in dialysis patients has significantly decreased over the past few decades due to screening of blood products for hepatitis B surface antigen (HBsAg) and hepatitis B core antibody, implementation of infection control measures and hepatitis B vaccination...
June 19, 2017: Liver International: Official Journal of the International Association for the Study of the Liver
https://www.readbyqxmd.com/read/28622450/large-esophageal-varice-screening-by-a-sequential-algorithm-using-a-cirrhosis-blood-test-and-optionally-capsule-endoscopy
#4
Paul Calès, Sylvie Sacher-Huvelin, Dominique Valla, Christophe Bureau, Anne Olivier, Frédéric Oberti, Jérôme Boursier, Jean Paul Galmiche
BACKGROUND & AIMS: Large esophageal varice (LEV) screening is recommended in cirrhosis. We performed a prospective study to improve non-invasive LEV screening. DESIGN: 287 patients with cirrhosis had upper gastrointestinal endoscopy (LEV reference), esophageal capsule endoscopy (ECE), liver elastography and blood marker analyses. CirrhoMeter (cirrhosis blood test), the most accurate non-invasive LEV test, was segmented for cirrhosis (reference comparator) or LEV...
June 16, 2017: Liver International: Official Journal of the International Association for the Study of the Liver
https://www.readbyqxmd.com/read/28618192/the-patient-buddy-app-can-potentially-prevent-hepatic-encephalopathy-related-readmissions
#5
Dinesh Ganapathy, Chathur Acharya, Jatinder Lachar, Kavish Patidar, Richard K Sterling, Melanie B White, Catherine Ignudo, Swamy Bommidi, John DeSoto, Leroy R Thacker, Scott Matherly, Jawaid Shaw, Mohammad S Siddiqui, Puneet Puri, Arun J Sanyal, Velimir Luketic, Hannah Lee, R Todd Stravitz, Jasmohan S Bajaj
BACKGROUND AND AIM: Readmissions are a major burden in cirrhosis. A proportion of readmissions in cirrhosis, especially due to hepatic encephalopathy (HE) could be avoided through patient and caregiver engagement. We aimed to define the feasibility of using the Patient Buddy App and its impact on 30-day readmissions by engaging and educating cirrhotic inpatients and caregivers in a pilot study. METHODS: Cirrhotic inpatients with caregivers were enrolled and followed for 30 days post-discharge...
June 15, 2017: Liver International: Official Journal of the International Association for the Study of the Liver
https://www.readbyqxmd.com/read/28618167/neuropilin-1-regulated-by-mir-320-contributes-to-the-growth-and-metastasis-of-cholangiocarcinoma-cells
#6
Huaqiang Zhu, Xian Jiang, Xu Zhou, Xuesong Dong, Kai Xie, Chuncheng Yang, Hongchi Jiang, Xueying Sun, Jun Lu
BACKGROUND: Neuropilin-1 (NRP-1) activates signaling pathways as multifunctional co-receptors in cancer cells. However, its role and how it is regulated by miRNAs in cholangiocarcinoma (CCA) have not yet been investigated. METHODS: The expression of NRP-1, miR-320 and key molecules involved in cell proliferation, migration and related signaling pathways were detected by immunohistochemistry, immunoblotting and qRT-PCR. Stable transfectants depleted of NRP-1 were generated...
June 15, 2017: Liver International: Official Journal of the International Association for the Study of the Liver
https://www.readbyqxmd.com/read/28618152/potential-risk-of-hbv-reactivation-in-patients-with-resolved-hbv-infection-undergoing-direct-acting-antiviral-treatment-for-hcv
#7
Eiichi Ogawa, Norihiro Furusyo, Masayuki Murata, Kazuhiro Toyoda, Takeo Hayashi, Kazuya Ura
BACKGROUND AND AIMS: Despite a known risk of hepatitis B virus (HBV) reactivation during direct-acting antiviral (DAA) treatment for patients with hepatitis C virus (HCV)-HBV coinfection, it remains unclear whether patients with past HBV infection are at risk for reactivation. This study evaluated the risk of HBV reactivation during treatment with sofosbuvir (SOF)-based regimens, focusing on patients with resolved HBV infection. METHODS: This study analyzes the data of 183 consecutive patients treated with SOF-based regimens...
June 15, 2017: Liver International: Official Journal of the International Association for the Study of the Liver
https://www.readbyqxmd.com/read/28609569/dic-in-decompensated-cirrhosis-caused-by-prothrombin-complex-concentrate-and-recombinant-activated-factor-vii-a-word-of-caution
#8
LETTER
Jason Glass, Gene Y Im
We would like to respond to Scott et al. and the accompanying editorial.(1,2) Concentrated factor products like recombinant activated factor VII (NovoSeven(®) , Novo Nordisk Pharmaceuticals Inc.) and prothrombin complex concentrate (Kcentra(®) , CSL Behring GmbH) are agents that can rapidly reverse coagulopathy for invasive procedures. This article is protected by copyright. All rights reserved.
June 13, 2017: Liver International: Official Journal of the International Association for the Study of the Liver
https://www.readbyqxmd.com/read/28609020/sorafenib-versus-surgical-resection-for-hepatocellular-carcinoma-with-macrovascular-invasion-a-propensity-score-analysis
#9
Charlotte E Costentin, Thomas Decaens, Alexis Laurent, Jean-Charles Nault, Bernard Paule, Christian Letoublon, Alain Luciani, Julien Calderaro, René Adam, Ivan Bricault, Giuliana Amaddeo, Daniel Cherqui, Ariane Mallat, Didier Samuel, Christophe Duvoux, Nathalie Ganne-Carrié, Françoise Roudot-Thoraval, Eric Vibert
BACKGROUND AND AIM: Sorafenib is the standard of care for patients with hepatocellular carcinoma (HCC) and macrovascular invasion (MVI), with limited survival. Retrospective surgical studies have reported prolonged survival in this situation. This study aimed to compare the overall survival of patients with HCC and MVI treated with surgical resection or sorafenib. METHODS: 143 patients with HCC and MVI but no extra-hepatic spread, treated with surgical resection (SR-patients; n=75) or sorafenib (SOR-patients; n=68) in four French centres between 1990 and 2013 were reviewed retrospectively...
June 13, 2017: Liver International: Official Journal of the International Association for the Study of the Liver
https://www.readbyqxmd.com/read/28608943/transcriptomic-and-histopathological-analysis-of-cholangiolocellular-differentiation-trait-in-intrahepatic-cholangiocarcinoma
#10
Hyungjin Rhee, Jung Eun Ko, Taek Chung, Byul A Jee, So Mee Kwon, Ji Hae Nahm, Jae Yeon Seok, Jeong Eun Yoo, Jin-Sub Choi, Snorri S Thorgeirsson, Jesper B Andersen, Hye Sun Lee, Hyun Goo Woo, Young Nyun Park
BACKGROUND & AIMS: Intrahepatic cholangiocarcinoma (iCCA) is a heterogeneous entity with diverse etiologies, morphologies, and clinical outcomes. Recently, histopathological distinction of cholangiolocellular differentiation (CD) of iCCA has been suggested. However, its genome-wide molecular features and clinical significance remain unclear. METHODS: Based on CD status, we stratified iCCAs into iCCA with CD (n=20) and iCCA without CD (n=102), and performed an integrative analysis using transcriptomic and clinicopathological profiles...
June 13, 2017: Liver International: Official Journal of the International Association for the Study of the Liver
https://www.readbyqxmd.com/read/28599083/mixed-cryoglobulinemia-an-important-but-frequently-unrecognized-and-underestimated-hcv-related-condition-in-the-real-life-practice
#11
LETTER
Loreta A Kondili, Stefano Vella, Anna Linda Zignego
We read with interest the paper "Effectiveness and cost of hepatitis C virus cryoglobulinemia vasculitis treatment: from interferon-based to direct acting antivirals era"(1), and we feel that the combination of effectiveness with a cost analysis is original and increases the awareness about patients with Mixed Cryoglobulinemia (MC). A dedicated approach, focusing on the diagnosis and on the impact of treatment of MC, have been included within the Italian Platform for the Study of Viral Hepatitis Therapies (PITER) (2)...
June 9, 2017: Liver International: Official Journal of the International Association for the Study of the Liver
https://www.readbyqxmd.com/read/28581252/nafld-in-clinical-practice-can-simple-blood-and-anthropometric-markers-be-used-to-detect-change-in-liver-fat-measured-by-1-h-mrs
#12
Shelley E Keating, Helen M Parker, Ingrid J Hickman, Sjaan R Gomersall, Matthew P Wallen, Jeff S Coombes, Graeme A Macdonald, Jacob George, Nathan A Johnson
BACKGROUND & AIMS: Research in NAFLD management is commonly based on quantitative assessment of liver fat by proton-magnetic resonance spectroscopy ((1) H-MRS), and translation of this into clinical practice is currently limited by availability and expense. Novel steatosis biomarkers have been proposed for the prediction of liver fatness; however, whether these are suitable for detecting changes in liver fat is unknown. We aimed to determine the accuracy of these indices, and waist circumference (WC), in quantifying longitudinal change in (1) H-MRS-quantified liver fat...
June 5, 2017: Liver International: Official Journal of the International Association for the Study of the Liver
https://www.readbyqxmd.com/read/28581250/new-intermediate-stage-subclassification-for-patients-with-hepatocellular-carcinoma-treated-with-transarterial-chemoembolization
#13
Jin Hyoung Kim, Ju Hyun Shim, Han Chu Lee, Kyu-Bo Sung, Heung-Kyu Ko, Gi-Young Ko, Dong Il Gwon, Jong Woo Kim, Young-Suk Lim, Seong Ho Park
AIM: The need for a subclassification of Barcelona Clinic Liver Cancer (BCLC) intermediate-stage (BCLC B) has arisen because of its diversity. We evaluated the prognostic capability of the BCLC B subclassification proposed by Bolondi et al. in patients treated with transarterial chemoembolization (TACE). Furthermore, we introduce a new subclassification for intermediate-stage hepatocellular carcinoma (HCC) by using a new parameter related to tumor burden (up-to-11 criteria). METHODS: Of 3268 patients treated with TACE as first-line treatment, 821 patients with intermediate-stage HCC were included in this study...
June 5, 2017: Liver International: Official Journal of the International Association for the Study of the Liver
https://www.readbyqxmd.com/read/28581248/non-invasive-tests-for-liver-disease-severity-and-the-hepatocellular-carcinoma-risk-in-chronic-hepatitis-b-patients-with-low-level-viremia
#14
Namyoung Paik, Dong Hyun Sinn, Ji Hyun Lee, In Soo Oh, Jung Hee Kim, Wonseok Kang, Geum-Youn Gwak, Yong-Han Paik, Moon Seok Choi, Joon Hyeok Lee, Kwang Cheol Koh, Seung Woon Paik
BACKGROUND & AIMS: We tested whether non-invasive tests for liver disease severity can stratify hepatocellular carcinoma (HCC) risk in chronic hepatitis B virus (HBV) infected patients showing low level viremia (LLV, HBV DNA < 2,000 IU/mL). METHODS: A retrospective cohort of 1,006 chronic hepatitis B patients showing persistently LLV, defined by at least two consecutive assessments in the year before enrollment, was assessed for HCC development. Two non-invasive serum biomarkers, the aspartate aminotransferase to platelet ratio index (APRI) and the Fibrosis-4 (FIB-4), were tested...
June 5, 2017: Liver International: Official Journal of the International Association for the Study of the Liver
https://www.readbyqxmd.com/read/28561454/hepatitis-b-treatment-eligibility-in-west-africa-uncertainties-and-need-for-prospective-cohort-studies
#15
Antoine Jaquet, Marcellin Nouaman, Judicaël Tine, Aristophane Tanon, Camille Anoma, André Inwoley, Alain Attia, Didier K Ekouevi, Moussa Seydi, François Dabis, Gilles Wandeler
BACKGROUND & AIMS: While universal screening of hepatitis B virus (HBV) is recommended in high burden countries, little is known about the proportion of HBV-infected persons in need of antiviral therapy in these settings. METHODS: Prisoners in Senegal and Togo, as well as female sex workers and men who have sex with men in Cote d'Ivoire were screened for HBV infection. All HBsAg-positive participants underwent transient elastography, alanine aminotransferase (ALT) and HBV viral load quantification...
May 31, 2017: Liver International: Official Journal of the International Association for the Study of the Liver
https://www.readbyqxmd.com/read/28561276/intestinal-microbiota-in-patients-with-chronic-hepatitis-c-with-and-without-liver-cirrhosis-compared-to-healthy-controls
#16
Benjamin Heidrich, Marius Vital, Iris Plumeier, Nico Döscher, Silke Kahl, Janina Kirschner, Szilvia Ziegert, Philipp Solbach, Henrike Lenzen, Andrej Potthoff, Michael Peter Manns, Heiner Wedemeyer, Dietmar Helmut Pieper
BACKGROUND AND AIMS: The importance of the intestinal microbiota for the onset and clinical course of many diseases, including liver diseases like non-alcoholic steatohepatitis and cirrhosis, is increasingly recognized. However, the role of intestinal microbiota in chronic HCV infection remains unclear. METHODS: In a cross sectional approach the intestinal microbiota of 95 patients chronically infected with HCV (n=57 without cirrhosis [NO-CIR]; n=38 with cirrhosis [CIR]) and 50 healthy controls (HC) without documented liver diseases was analysed...
May 31, 2017: Liver International: Official Journal of the International Association for the Study of the Liver
https://www.readbyqxmd.com/read/28557143/liver-stiffness-reduction-correlates-with-histological-characteristics-of-hepatitis-c-patients-with-sustained-virological-response
#17
Yoshihiko Tachi, Takanori Hirai, Yuko Kojima, Yoji Ishizu, Takashi Honda, Teiji Kuzuya, Kazuhiko Hayashi, Masatoshi Ishigami, Hidemi Goto
BACKGROUND AND AIMS: We investigated the correlation between histological characteristics and changes in liver stiffness in patients with sustained virological response using acoustic radiation force impulse elastography. METHODS: In this prospective study, we enrolled 176 Hepatitis C patients with sustained virological response who underwent acoustic radiation force impulse elastography and liver biopsy before antiviral treatment, and serial acoustic radiation force impulse elastography at the end of treatment and at 24 weeks after the end of treatment...
May 30, 2017: Liver International: Official Journal of the International Association for the Study of the Liver
https://www.readbyqxmd.com/read/28556413/concomitant-screening-for-liver-fibrosis-and-steatosis-in-french-type-2-diabetic-patients-using-fibroscan
#18
Dominique Roulot, Françoise Roudot-Thoraval, Gisele Nkontchou, Narcisse Kouacou, Jean Luc Costes, Ghassan Elourimi, Hervé Le Clesiau, Marianne Ziol, Michel Beaugrand
BACKGROUND: Type 2 diabetes is a risk factor for steatohepatitis and fibrosis. Non-invasive liver stiffness (LS) and controlled attenuation parameter (CAP) measurements by Fibroscan allow assessing liver fat and fibrosis. AIM: To determine the prevalence of steatosis and significant fibrosis in a community-based diabetic population METHODS: LS and CAP were measured in 705 patients using the standard "M probe". A second "XL probe" was used, without CAP measurement, in case of failure with the "M probe"...
May 27, 2017: Liver International: Official Journal of the International Association for the Study of the Liver
https://www.readbyqxmd.com/read/28544769/serum-biomarkers-can-predict-a-change-in-liver-fibrosis-one-year-after-lifestyle-intervention-for-biopsy-proven-nash
#19
Eduardo Vilar-Gomez, Luis Calzadilla-Bertot, Scott L Friedman, Bienvenido Gra-Oramas, Licet Gonzalez-Fabian, Sacha Lazo-Del Vallin, Moises Diago, Leon A Adams
BACKGROUND & AIMS: The dynamic response of serum fibrosis biomarkers to histological changes within the liver following lifestyle intervention (LI) is unknown. We explored relationships between changes in serum biomarkers and liver fibrosis in NASH patients undergoing LI. METHODS: Paired liver biopsies were performed in 261 NASH patients to assess fibrosis change after 1 year of LI. We explored the utility of serum fibrosis markers to predict changes in hepatic fibrosis and developed and internally validated a model for predicting fibrosis improvement in patients with baseline fibrosis...
May 24, 2017: Liver International: Official Journal of the International Association for the Study of the Liver
https://www.readbyqxmd.com/read/28544258/incidence-and-risk-factors-for-non-alcoholic-fatty-liver-disease-a-7-year-follow-up-study-among-urban-adult-sri-lankans
#20
Madunil A Niriella, Arunasalam Pathmeswaran, Shamila T De Silva, Anuradhani Kasturiratna, Ruwan Perera, Chamila E Subasinghe, Kuleesha Kodisinghe, Chathura Piyaratna, Vithiya Rishikesawan, Anuradha S Dassanayaka, Arjuna P De Silva, Rajitha Wickramasinghe, Fumihiko Takeuchi, Norihiro Kato, Hithanadura J de Silva
BACKGROUND: This study investigated incidence and risk factors for NAFLD among an adult cohort with 7-year follow-up. METHODS: The study population (age-stratified random sampling, Ragama MOH area) was screened initially in 2007 (aged 35-64 years) and re-evaluated in 2014 (aged 42-71 years). On both occasions assessed by structured interview, anthropometric measurements, liver ultrasound, biochemical and serological tests. NAFLD was diagnosed on ultrasound criteria, safe alcohol consumption and absence of hepatitis B/C markers...
May 19, 2017: Liver International: Official Journal of the International Association for the Study of the Liver
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