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Liver International: Official Journal of the International Association for the Study of the Liver

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https://www.readbyqxmd.com/read/29325220/profile-risk-factors-and-outcome-of-acute-kidney-injury-in-pediatric-acute-on-chronic-liver-failure
#1
Bikrant Bihari Lal, Seema Alam, Vikrant Sood, Dinesh Rawat, Rajeev Khanna
There are no studies on acute kidney injury (AKI) in pediatric acute-on-chronic liver failure (ACLF). This study was planned with aim to describe the clinical presentation and outcome of AKI among pediatric ACLF patients METHODS: Data of all children 1-18 years of age presenting with ACLF (APASL definition) was reviewed. AKI was defined as per KDIGO guidelines. Poor outcome was defined as death or need for liver transplant within 3 months of development of AKI RESULTS: A total of 84 children with ACLF presented to us in the study period...
January 11, 2018: Liver International: Official Journal of the International Association for the Study of the Liver
https://www.readbyqxmd.com/read/29323459/reliability-and-safety-of-transnasal-compared-to-conventional-endoscopy-for-detecting-esophageal-varices-in-cirrhotic-patients
#2
Elio C Castro Filho, Hugo Perazzo, Raquel Al-Cici P Guimaraes, Lilian Machado, Flavia F Fernandes, Renata M Perez
BACKGROUND & AIMS: Unsedated transnasal endoscopy may be used for detecting esophageal varices. However, few studies evaluated feasibility and accuracy of this technique. We aimed to evaluate accuracy, interobserver agreement and safety of the transnasal ultrathin compared to conventional endoscopy in patients with cirrhosis. METHODS: This cross-sectional study included consecutive patients referred for screening or surveillance of esophageal varices. Patients underwent unsedated transnasal and sedated conventional endoscopies at the same day, which were recorded in a digital video file and randomly analyzed by two double-blinded endoscopists...
January 11, 2018: Liver International: Official Journal of the International Association for the Study of the Liver
https://www.readbyqxmd.com/read/29323441/a-low-muscle-mass-increases-mortality-in-compensated-cirrhotic-patients-with-sepsis
#3
Cristina Lucidi, Barbara Lattanzi, Vincenza Di Gregorio, Simone Incicco, Daria D'Ambrosio, Mario Venditti, Oliviero Riggio, Manuela Merli
BACKGROUND & AIMS: Severe infections and muscle wasting are both associated to poor outcome in cirrhosis. A possible synergic effect of these two entities in cirrhotic patients has not been previously investigated. We aimed at analyzing if a low muscle mass may deteriorate the outcome of cirrhotic patients with sepsis. METHODS: Consecutive cirrhotic patients hospitalized for sepsis were enrolled. Patients were classified for the severity of liver impairment (Child-Pugh class) and for the presence of "low muscle mass" (mid-arm muscle circumference<5th percentile)...
January 11, 2018: Liver International: Official Journal of the International Association for the Study of the Liver
https://www.readbyqxmd.com/read/29314597/effect-of-ombitasvir-paritaprevir-ritonavir-dasabuvir%C3%A2-regimen-on-health-related-quality-of-life-for-patients-with-hepatitis-c
#4
Sammy Saab, Darshan Mehta, Stacie Hudgens, Nathan Grunow, Yanjun Bao, Brett Pinsky
BACKGROUND AND AIMS: This study analyzes health related quality of life (HRQoL) data from 8 randomized clinical trials using ombitasvir/paritaprevir/ritonavir and dasabuvir (3D) ± ribavirin [RBV] to investigate: [1] the impact of the treatment vs. placebo during treatment on HRQoL; [2] the sustainability of such treatment effect after 12-week treatment period; and [3] if results from [1] and [2] differ in subgenotypes 1a vs. 1b. METHODS: Six registration trials and 2 post-approval trials were pooled and analyzed using longitudinal mixed models (MM) to estimate the effect of 3D + RBV on HRQoL outcomes adjusting for baseline scores, as well as patient demographics and clinical characteristics...
January 5, 2018: Liver International: Official Journal of the International Association for the Study of the Liver
https://www.readbyqxmd.com/read/29314568/genetic-determinants-of-hepatic-steatosis-and-serum-cytokeratin-18-fragment-levels-in-taiwanese-children
#5
Yu-Cheng Lin, Pi-Feng Chang, Mei-Hwei Chang, Yen-Hsuan Ni
BACKGROUND/AIMS: There are substantial genetic components contributing to the susceptibility of nonalcoholic NAFLD disease (NAFLD). It has recently been reported that the rs641738 C>T variant in the membrane-bound O-acyltransferase domain-containing protein 7 (MBOAT7) gene increased severity of NAFLD in adults of European descent. We aimed to test the hypothesis that MBOAT7 rs641738 variant would increase hepatic steatosis and hepatocellular injury in obese children. METHODS: A total of 831 obese children aged 7-15 years were recruited...
January 4, 2018: Liver International: Official Journal of the International Association for the Study of the Liver
https://www.readbyqxmd.com/read/29314711/mir-492-regulates-metastatic-properties-of-hepatoblastoma-via-cd44
#6
Julia von Frowein, Stefanie M Hauck, Roland Kappler, Philipp Pagel, Katrin K Fleischmann, Thomas Magg, Stefano Cairo, Adelbert Roscher, Dietrich von Schweinitz, Irene Schmid
BACKGROUND & AIMS: MicroRNAs are important genetic regulators of physiological and pathophysiological processes including cancer initiation and progression of hepatoblastoma, the most common liver tumor in childhood. We aimed to identify malignant and metastasis promoting effects of miR-492, a miRNA we previously reported to be overexpressed in metastatic hepatoblastoma. Further, we intended to evaluate its diagnostic and prognostic potential. METHODS: Stable and transient overexpression of miR-492 in two liver tumor cell lines HepT1 and HUH7 was used to analyze features of metastatic tumor progression like proliferation, anchorage independent growth, migration and invasion...
January 3, 2018: Liver International: Official Journal of the International Association for the Study of the Liver
https://www.readbyqxmd.com/read/29314613/validation-and-comparison-of-seventeen-noninvasive-models-for-evaluating-liver-fibrosis-in-chinese-hepatitis-b-patients
#7
Minhui Dong, Jingwen Wu, Xueping Yu, Jing Li, Sisi Yang, Xun Qi, Richeng Mao, Yongmei Zhang, Jie Yu, Haoxiang Zhu, Feifei Yang, Yanli Qin, Jiming Zhang
BACKGROUND & AIMS: To avoid liver biopsy, many noninvasive models comprised of serum markers for liver fibrosis assessment have been developed. Given that most of them were developed in hepatitis C cohorts and few of them have been validated in Chinese hepatitis B patients, we aim to conduct this validation and compare their diagnostic accuracies in such a population. METHODS: A total of 937 HBV infected patients who underwent liver biopsy were included in this single-center retrospective study...
January 3, 2018: Liver International: Official Journal of the International Association for the Study of the Liver
https://www.readbyqxmd.com/read/29297981/primary-biliary-cholangitis-in-british-columbia-first-nations-clinical-features-and-discovery-of-novel-genetic-susceptibility-loci
#8
Sirisha Asuri, Sarah McIntosh, Valerie Taylor, Andrew Rokeby, James Kelly, Karey Shumansky, L Leigh Field, Eric M Yoshida, Laura Arbour
BACKGROUND AND AIMS: Primary Biliary Cholangitis (PBC) is a chronic autoimmune liver disease characterized by destruction of intrahepatic bile ducts, portal inflammation, and cirrhosis. Although rare in most populations, it is prevalent and often familial in British Columbia First Nations. We hypothesized that major genetic factors increased the risk in First Nations. METHODS: 44 individuals with PBC and 61 unaffected relatives from 32 First Nations families participated...
January 3, 2018: Liver International: Official Journal of the International Association for the Study of the Liver
https://www.readbyqxmd.com/read/29297980/ledipasvir-sofosbuvir-for-treating-japanese-patients-with-chronic-hepatitis-c-virus-genotype-2-infection
#9
Yasuhiro Asahina, Yoshito Itoh, Yoshiyuki Ueno, Yasushi Matsuzaki, Yasuhiro Takikawa, Hiroshi Yatsuhashi, Takuya Genda, Fusao Ikeda, Takuma Matsuda, Hadas Dvory-Sobol, Deyuan Jiang, Benedetta Massetto, Anu O Osinusi, Diana M Brainard, John G McHutchison, Norifumi Kawada, Nobuyuki Enomoto
BACKGROUND & AIMS: Japanese patients with chronic hepatitis C virus (HCV) genotype 2 infection have high rates of sustained virologic response (SVR) following 12 weeks of treatment with the nucleotide polymerase inhibitor sofosbuvir in combination with ribavirin, which was the standard of care at the time this study was undertaken. We assessed the efficacy of 12 weeks of treatment with a ribavirin-free regimen of ledipasvir-sofosbuvir. METHODS: In an open-label, Phase 3 trial we enrolled Japanese patients with chronic HCV genotype 2 infection, with or without compensated cirrhosis...
January 3, 2018: Liver International: Official Journal of the International Association for the Study of the Liver
https://www.readbyqxmd.com/read/29297975/clinical-characteristics-and-treatment-of-pyrrolizidine-alkaloid-related-hepatic-vein-occlusive-disease
#10
Yuzheng Zhuge, Yi Wang, Feng Zhang, Chengkai Zhu, Wei Zhang, Ming Zhang, Qibin He, Jian Yang, Jian He, Jun Chen, Xiaoping Zou
BACKGROUND AND AIMS: Hematopoietic stem cell transplantation related hepatic vein occlusive disease (HSCT-HVOD) has been researched extensively; however, little is known about the clinical features and treatment of pyrrolizidine alkaloid-induced HVOD (PA-HVOD). This retrospective single center study examined the clinical and laboratory characteristics of 108 patients with acute PA-HVOD and explored the efficacy of anticoagulation and TIPS therapy. METHODS: The study included 108 consecutive patients with PA-HVOD between July 2008 and June 2016...
January 3, 2018: Liver International: Official Journal of the International Association for the Study of the Liver
https://www.readbyqxmd.com/read/29297972/prognostic-scoring-systems-and-outcome-of-endovascular-radiological-intervention-of-chronic-budd-chiari-syndrome-in-children
#11
Sumit Kumar Singh, Moinak Sen Sarma, Rajanikant Yadav, Sheo Kumar, Raghunandan Prasad, Surender Kumar Yachha, Anshu Srivastava, Ujjal Poddar
BACKGROUND AND AIM: Prognostic scoring systems (PSS) have not been validated in children with chronic Budd-Chiari syndrome (BCS). We aimed to analyse the long-term outcome of radiological intervention (RI) and validate the PSS in children. METHODS: Chronic BCS children were analysed in four subgroups: SI: successful intervention (primary or secondary stent patency) b) PO: poor outcome (refractory stent block or requirement of liver transplantation), c) NU: naïve unintervened (awaiting RI) and d) DBI: died before intervention...
January 3, 2018: Liver International: Official Journal of the International Association for the Study of the Liver
https://www.readbyqxmd.com/read/29288595/inpatient-hospital-burden-of-hepatitis-c-diagnosed-patients-with-decompensated-cirrhosis
#12
Scott A McDonald, Hamish A Innes, Esther Aspinall, Peter C Hayes, Maryam Alavi, Heather Valerio, David J Goldberg, Sharon J Hutchinson
BACKGROUND & AIMS: To describe the burden on inpatient hospital resources over time from patients diagnosed with hepatitis C virus (HCV) infection and who have reached the decompensated stage of cirrhosis (DC), as existing estimates of hospital stay in these patients are limited. METHODS: A retrospective longitudinal dataset was formed via record-linkage between the national HCV diagnosis database and inpatient/daycase hospitalisation and death registers in Scotland...
December 30, 2017: Liver International: Official Journal of the International Association for the Study of the Liver
https://www.readbyqxmd.com/read/29288514/high-efficacy-of-ombitasvir-paritaprevir-ritonavir-plus-dasabuvir-in-hepatitis-c-genotypes-4-and-1-infected-patients-with-severe-chronic-kidney-disease
#13
Faisal M Sanai, Abdullah S Alghamdi, Ahmad A Afghani, Khalid Alswat, Adnan AlZanbagi, Mosfer N Alghamdi, Abdallah AlMousa, Mohammed Aseeri, Abdullah M Assiri, Mohamed A Babatin
Limited data has shown high efficacy of co-formulated ombitasvir/paritaprevir/ritonavir (OBV/PTV/r) in the treatment of hepatitis C virus (HCV) genotype (GT)-4, and combined with dasabuvir (DSV) in GT1 patients, with chronic kidney disease (CKD) stage 4-5 (<30 mL/min/1.73 m2 ). We assessed real-world safety and efficacy of OBV/PTV/r ± DSV in GT1 and 4-infected patients. METHODS: In this observational cohort (n=67), we enrolled stage 4-5 CKD treatment-naïve or Peginterferon/RBV-experienced GT4-infected patients (n=32) treated for 12-24 weeks with OBV/PTV/r ± RBV, and plus DSV in GT1 patients (n=35, including 3 with GT1/4 co-infection)...
December 29, 2017: Liver International: Official Journal of the International Association for the Study of the Liver
https://www.readbyqxmd.com/read/29285885/a-mutation-in-the-progesterone-receptor-predisposes-to-hev-infection-in-hiv-positive-patients
#14
Jose D Debes, Suzan D Pas, Zwier M A Groothuismink, Marchina E van der Ende, Robert A de Man, Andre Boonstra
BACKGROUND AND AIMS: Infection with Hepatitis E virus (HEV) can cause chronic liver disease in immunocompromised hosts. In transplant recipients the use of certain immunosuppressants and food habits have been proposed as risk factors for HEV. In individuals infected with the human immunodeficiency virus (HIV), risk factors for HEV infection are less clear. We aimed to study the association between a mutation in the progesterone receptor (PR) named PROGINS and HEV-infection in HIV-positive individuals...
December 28, 2017: Liver International: Official Journal of the International Association for the Study of the Liver
https://www.readbyqxmd.com/read/29285861/biliary-versus-thyroid-like-a-tale-of-two-morphologies
#15
Sharon J Song, Kathleen Montone, Kristen Stashek, Rashmi Tondon
Pictured here is a portacaval lymph node biopsy from a 72-year-old man with an 11.9 cm liver mass and several enlarged surrounding lymph nodes. The node was involved by a tumor with two distinct morphologies-one area resembling a primary pancreaticobiliary tumor (Figure 1) and another mimicking a thyroid follicular carcinoma with microfollicles containing brightly eosinophilic, colloid-like secretions (Figure 2). Immunohistochemistry showed the neoplastic cells to stain strongly with CK7 and CK19, with patchy positivity for CK20...
December 28, 2017: Liver International: Official Journal of the International Association for the Study of the Liver
https://www.readbyqxmd.com/read/29283494/genetic-association-of-complement-component-2-variants-with-chronic-hepatitis-b-in-a-korean-population
#16
Suhg Namgoong, Joong-Gon Shin, Hyun Sub Cheong, Lyoung Hyo Kim, Ji On Kim, Jung Yeon Seo, Hyoung Doo Shin, Yoon Jun Kim
BACKGROUND & AIMS: Numerous single nucleotide polymorphisms (SNPs) associated with an increased risk of liver diseases, chronic hepatitis B (CHB) and CHB-related hepatocellular carcinoma (HCC), have been identified. In this study, we scrutinized the genetic effects of C2 variants, which were conflicting in previous results, on the risk of CHB in a Korean population. METHODS: We genotyped 22 common C2 genetic variants of 977 CHB cases including 302 CHB-related HCC cases and 785 population controls...
December 28, 2017: Liver International: Official Journal of the International Association for the Study of the Liver
https://www.readbyqxmd.com/read/29282863/full-length-title-a-foretold-hepatitis-a-outbreak-in-france
#17
LETTER
Aurélie Martin, Amélie Menard, Patrick Borentain, Philippe Colson
We read with great interest the article by Rodríguez-Tajes et al.1 that describes an ongoing hepatitis A virus (HAV) outbreak in Spain. In Europe, such outbreaks, mostly affecting men-having-sex-with-men (MSM), have been described since 2016. This article is protected by copyright. All rights reserved.
December 28, 2017: Liver International: Official Journal of the International Association for the Study of the Liver
https://www.readbyqxmd.com/read/29271562/hcv-treatment-initiation-in-persons-with-chronic-kidney-disease-in-the-directly-acting-antiviral-agents-era-results-from-erchives
#18
Adeel A Butt, Yanjie Ren, Amy Puenpatom, Jean Marie Arduino, Ritesh Kumar, Abdul-Badi Abou-Samra
BACKGROUND: Newer direct acting antiviral agents against HCV (DAAs) are safe and efficacious in persons with chronic kidney disease (CKD). Whether approval of newer DAAs has resulted in more persons with CKD initiating HCV treatment remains unknown. METHODS: We identified HCV+ persons in ERCHIVES between October 1999 and July 2016. We excluded HIV+ and HBsAg+ and those with missing baseline HCV RNA and baseline eGFR data. We identified persons initiated on any approved DAA-regimen through July 2016, by CKD stage...
December 22, 2017: Liver International: Official Journal of the International Association for the Study of the Liver
https://www.readbyqxmd.com/read/29266722/impact-of-resection-and-ablation-for-single-hypovascular-hepatocellular-carcinoma-%C3%A2-2-cm-analyzed-with-propensity-score-weighting
#19
Kenichi Takayasu, Shigeki Arii, Michiie Sakamoto, Yutaka Matsuyama, Masatoshi Kudo, Shuichi Kaneko, Osamu Nakashima, Masumi Kadoya, Namiki Izumi, Tadatoshi Takayama, Yonson Ku, Takashi Kumada, Shoji Kubo, Takashi Kokudo, Yasuhiro Hagiwara, Norihiro Kokudo
Small hypovascular hepatocellular carcinoma (HCC) ≤2 cm is biologically less aggressive than hypervascular one however, the optimal treatment is still undetermined. The efficacy of surgical resection (SR), radiofrequency ablation (RFA), and percutaneous ethanol injection (PEI) was evaluated METHODS: The 853 (SR, 176; RFA, 491; PEI, 186) patients were enrolled who met Child-Pugh A/B, single hypovascular HCC ≤2 cm pathologically proven, available tumor differentiation, and absence of macrovascular invasion and extrahepatic metastasis...
December 21, 2017: Liver International: Official Journal of the International Association for the Study of the Liver
https://www.readbyqxmd.com/read/29265719/hcv-eradication-by-daa-improves-glucose-tolerance-and-reduces-post-load-insulin-resistance-in-nondiabetic-patients-with-genotype-1
#20
Federico Salomone, Maurizio Catania, Arturo Montineri, Gaetano Bertino, Justyna Godos, Leonardo Rizzo, Giovanni Magrì, Giovanni Li Volti
BACKGROUND AND AIMS: Genotype 1 chronic hepatitis C (CHC) is associated with an impairment of glucose homeostasis, especially in the advanced stages of the disease. Glucose tolerance is an independent predictor of liver-related mortality in patients with cirrhosis due to CHC. However, no study has demonstrated so far weather HCV clearance affects glucose tolerance. METHODS: To this aim, we performed a prospective study assessing the effects of DAA treatment in non-diabetic cirrhotic patients with genotypes 1a/1b and impaired glucose tolerance (IGT) based on a 75-g oral glucose tolerance test (OGTT)...
December 19, 2017: Liver International: Official Journal of the International Association for the Study of the Liver
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