journal
MENU ▼
Read by QxMD icon Read
search

Liver International: Official Journal of the International Association for the Study of the Liver

journal
https://www.readbyqxmd.com/read/28517369/treatment-of-primary-biliary-cholangitis-non-responders-a-systematic-review
#1
Duminda Suraweera, Harman Rahal, Melissa Jimenez, Matthew Viramontes, Gina Choi, Sammy Saab
BACKGROUND: Primary biliary cholangitis (PBC), formerly known as primary biliary cirrhosis, is a chronic cholestatic liver disease characterized by an immune mediated destruction of intrahepatic bile ducts. Ursodeoxycholic acid (UDCA) has been the primary medication for the treatment of PBC, resulting in improved liver tests, resolution of symptoms and increased transplant free survival. However, not all patients respond to UDCA. The aim of this systematic review is to provide an evidence based assessment of the medications that have been studied in patients who are refractory to UDCA...
May 18, 2017: Liver International: Official Journal of the International Association for the Study of the Liver
https://www.readbyqxmd.com/read/28508586/role-and-regulation-of-autophagy-and-apoptosis-by-nitric-oxide-in-hepatic-stellate-cells-during-acute-liver-failure
#2
Li Jin, Heng Gao, JiuPing Wang, ShuJuan Yang, Jing Wang, JingFeng Liu, Yuan Yang, TaoTao Yan, Tianyan Chen, Yingren Zhao, Yingli He
BACKGROUND & AIMS: We previously found that hepatic stellate cell (HSC) activation induced by autophagy maintains the liver architecture to prevent collapse during acute liver failure (ALF). Nitric oxide (NO) has shown to induce HSC apoptosis. Whether and how NO is involved in ALF and autophagy remains unclear. METHODS: ALF patients were recruited to investigate the correlation between plasma NO levels and clinical features. Liver tissues were collected from chronic hepatitis patients by biopsy and from ALF patients who had undergone liver transplantation...
May 15, 2017: Liver International: Official Journal of the International Association for the Study of the Liver
https://www.readbyqxmd.com/read/28500636/immune-correlates-of-hepatitis-b-surface-antigen-spontaneous-seroconversion-in-hepatitis-b-e-antigen-negative-chronic-hepatitis-b-patients
#3
Ashish Kumar Vyas, Barjesh Chander Sharma, Shiv Kumar Sarin, Nirupma Trehanpati
BACKGROUND: Hepatitis B surface antigen (HBsAg) seroconversion in HBeAg-ve chronic hepatitis B (CHB) infection is rare, possibly due to poor antigen processing and impaired humoral response. We investigated the role of dendritic cells (DCs), T follicular helper (TFH) cells and plasma B cells in seroconversion. METHODS: HBeAg-ve (n=135) CHB patients with raised ALT at baseline were followed-up. Patients undergoing HBsAg sero-conversion (Gr. I, n=11) were compared with non-converters with low (Gr...
May 13, 2017: Liver International: Official Journal of the International Association for the Study of the Liver
https://www.readbyqxmd.com/read/28489307/non-alcoholic-fatty-liver-nafl-and-advanced-fibrosis-in-the-elderly-results-from-a-community-based-polish-survey
#4
Marek Hartleb, Kamil Barański, Jan Zejda, Jerzy Chudek, Andrzej Więcek
INTRODUCTION & AIM: Development of non-alcoholic fatty liver (NAFL) is dependent on metabolic factors occurring at an increased frequency with advancing age. Until now, few studies have explored the prevalence of NAFL in aged populations. Our study aimed to determine the prevalence of NAFL and advanced fibrosis in the elderly population participating in a national survey of a community-based elderly cohort. METHODS: A total of 3003 participants (mean age 79.6 years, 46...
May 10, 2017: Liver International: Official Journal of the International Association for the Study of the Liver
https://www.readbyqxmd.com/read/28482131/incidence-of-acute-hepatitis-a-among-hiv-positive-patients-during-an-outbreak-among-msm-in-taiwan-impact-of-hav-vaccination
#5
Guan-Jhou Chen, Kuan-Yin Lin, Hsin-Yun Sun, Wang-Huei Sheng, Szu-Min Hsieh, Yi-Chia Huang, Aristine Cheng, Wen-Chun Liu, Chien-Ching Hung, Shan-Chwen Chang
BACKGROUND: An unprecedented outbreak of acute hepatitis A has occurred among MSM in Taiwan since June 2015. We aimed to describe the seroepidemiology of HAV infection and to investigate the relationship between HAV vaccination and the incidence of acute hepatitis A among HIV-positive patients at the largest designated hospital for HIV care during the outbreak. METHODS: Between 2012 and 2016, the HAV serostatus, vaccination history, and clinical characteristics of HIV-positive patients were retrospectively reviewed...
May 8, 2017: Liver International: Official Journal of the International Association for the Study of the Liver
https://www.readbyqxmd.com/read/28481460/high-efficacy-of-sofosbuvir-plus-simeprevir-in-a-large-cohort-of-spanish-cirrhotic-patients-infected-with-genotypes-1-and-4
#6
Zoe Mariño, Juan Manuel Pascasio-Acevedo, Adolfo Gallego, Moisés Diago, Carme Baliellas, Rosa Morillas, Martín Prieto, José María Moreno, Gloria Sánchez-Antolín, Mercedes Vergara, Montserrat Forné, Inmaculada Fernández, Maria Ángeles Castro, Sonia Pascual, Alexandra Gómez, Lluis Castells, Jose Luis Montero, Javier Crespo, Jose Luis Calleja, Javier García-Samaniego, Jose Antonio Carrión, Ana Del Carmen Arencibia, Alejandro Blasco, Carmen López-Núñez, Juan José Sánchez-Ruano, Francisco Gea-Rodríguez, Álvaro Giráldez, Joaquín Cabezas, Vanessa Hontangas, Xavier Torras, Jose Castellote, Manuel Romero-Gómez, Juan Turnes, Tomás de Artaza, Isidoro Narváez, Valentín Cuervas-Mons, Xavier Forns
BACKGROUND AND AIMS: Hepatitis C (HCV) therapy with Sofosbuvir(SOF)/ Simeprevir(SMV) in clinical trials and real-world clinical practice, showed high rates of sustained virological response (SVR) in non-cirrhotic genotype(GT)-1 and 4 patients. These results were slightly lower in cirrhotic patients. We investigated real-life effectiveness and safety of SOF/SMV with or without ribavirin(RBV) in a large cohort of cirrhotic patients. METHODS: This collaborative multicentre study included data from 968 patients with cirrhosis infected with HCV-GT1 or 4, treated with SOF/SMV±RBV in 30 centres across Spain between January-2014 and December-2015...
May 8, 2017: Liver International: Official Journal of the International Association for the Study of the Liver
https://www.readbyqxmd.com/read/28481452/hepatitis-b-in-egypt-a-cross-sectional-analysis-of-prevalence-and-risk-factors-for-active-infection-from-a-nationwide-survey
#7
Sharif A Ismail, Diego F Cuadros, Lenka Benova
BACKGROUND AND AIMS: viral hepatitis is a major public health challenge in Egypt but little is known about the epidemiology of the hepatitis B virus (HBV) infection, its geographical distribution, or risk factors for infection in the Egyptian context. This study addresses this deficit using data from a nationally-representative survey. METHODS: cross-sectional analysis of data gathered from men and women aged 15-59 in the Egypt Health Issues Survey (EHIS) 2015, including logistic regression to evaluate the contribution of different factors to risk of HBV infection...
May 8, 2017: Liver International: Official Journal of the International Association for the Study of the Liver
https://www.readbyqxmd.com/read/28481424/evaluating-hepatocellular-carcinoma-cell-lines-for-tumor-samples-using-within-sample-relative-expression-orderings-of-genes
#8
Lu Ao, You Guo, Xuekun Song, Qingzhou Guan, Weicheng Zheng, Jiahui Zhang, Haiyan Huang, Yi Zou, Zheng Guo, Xianlong Wang
BACKGROUND & AIMS: Concerns are raised about the representativeness of cell lines for tumors due to the culture environment and misidentification. Liver is a major metastatic destination of many cancers, which might further confuse the origin of hepatocellular carcinoma (HCC) cell lines. Therefore, it is of crucial importance to understand how well they can represent HCC. METHODS: The HCC-specific gene pairs with highly stable relative expression orderings (REOs) in more than 99% of HCC but with reversed REOs in at least 99% of one of the six types of cancer, colorectal carcinoma (CRC), breast carcinoma (BRC), non-small-cell lung cancer, gastric carcinoma, pancreatic carcinoma and ovarian carcinoma, were identified...
May 8, 2017: Liver International: Official Journal of the International Association for the Study of the Liver
https://www.readbyqxmd.com/read/28470938/patient-reported-outcomes-in-patients-co-infected-with-hcv-and-hiv-treated-with-sofosbuvir-and-velpatasvir-the-astral-5-study
#9
Zobair M Younossi, Maria Stepanova, Mark Sulkowski, David Wyles, Shyam Kottilil, Sharon Hunt
BACKGROUND AND AIM: The fixed-dose combination of sofosbuvir and velpatasvir (SOF/VEL) is a ribavirin-free pan-genotypic regimen with high efficacy. We assessed the impact of SOF/VEL on patient-reported outcomes (PRO) of HIV-HCV co-infected patients. METHODS: HIV-HCV co-infected patients were treated with 12 weeks of SOF/VEL (400mg/100mg daily). All subjects completed 4 PRO questionnaires [CLDQ-HCV, SF-36, FACIT-F, WPAI:SHP] before, during, and post-treatment. RESULTS: ASTRAL-5 enrolled 106 HIV-HCV co-infected patients on stable anti-retroviral therapy (age: 54...
May 4, 2017: Liver International: Official Journal of the International Association for the Study of the Liver
https://www.readbyqxmd.com/read/28467688/effectiveness-and-cost-of-hepatitis-c-virus-cryoglobulinemia-vasculitis-treatment-from-interferon-based-to-direct-acting-antivirals-era
#10
Patrice Cacoub, Mathieu Vautier, Anne Claire Desbois, Antoine Lafuma, David Saadoun
BACKGROUND: The net benefits of new hepatitis C virus (HCV) direct acting antiviral drugs (DAA) in patients with cryoglobulinemia vasculitis (CryoVas) are unknown. OBJECTIVE: To analyze the effectiveness and cost of all treatments used for HCV-CryoVas in the DAA versus pre-DAA era. METHODS: A chart review of all HCV-CryoVas patients who received antivirals from 1993 to 2016 in a tertiary center was performed. Treatment effectiveness was analyzed for clinical, immunological and virological responses...
May 3, 2017: Liver International: Official Journal of the International Association for the Study of the Liver
https://www.readbyqxmd.com/read/28467657/effect-of-smoking-on-survival-of-patients-with-hepatocellular-carcinoma
#11
Philippe Kolly, Marina Knöpfli, Jean-François Dufour
BACKGROUND & AIMS: Lifestyle factors such as smoking, obesity, and physical activity have gained interest in the field of hepatocellular carcinoma (HCC). These factors play a significant role in the development of HCC. Several studies revealed the impact of tobacco consumption on the development of HCC and its synergistic effects with viral etiologies (hepatitis B and C). The effects of smoking on survival in patients with a diagnosed HCC have not yet been investigated in a Western cohort where hepatitis C infection is a major risk factor...
May 3, 2017: Liver International: Official Journal of the International Association for the Study of the Liver
https://www.readbyqxmd.com/read/28440908/cautious-use-of-platelet-as-a-relevant-inducer-of-liver-regeneration-following-partial-hepatectomy-in-patients-with-metastatic-hepatic-carcinoma
#12
LETTER
Qing Pang, Huichun Liu, Lei Zhou, Hao Jin
The article by Kirschbaum et al. (1) shows that temporary von Willebrand factor-mediated platelet influx in the liver remnant drives platelet-mediated liver regeneration (LR) following partial hepatectomy. Indeed, there is mounting evidence that platelet and endogenous factors are beneficial to hepatocyte regeneration in patients with hepatocellular carcinoma (HCC). Furthermore, platelet-increasing therapy has been recommended to improve LR following partial hepatectomy. However, we want to point out that, platelets may play adverse roles in the remnant liver of HCC and metastatic hepatic carcinoma (MHC) patients...
April 25, 2017: Liver International: Official Journal of the International Association for the Study of the Liver
https://www.readbyqxmd.com/read/28494113/the-diagnostic-conundrum-of-bacterial-infections-in-cirrhotic-patients
#13
LETTER
Alberto Enrico Maraolo, Daniele Roberto Giacobbe, Marco Fiore
No abstract text is available yet for this article.
April 24, 2017: Liver International: Official Journal of the International Association for the Study of the Liver
https://www.readbyqxmd.com/read/28432836/autoimmune-hepatitis-from-current-knowledge-and-clinical-practice-to-future-research-agenda
#14
REVIEW
Marcial Sebode, Johannes Hartl, Diego Vergani, Ansgar W Lohse
Autoimmune hepatitis is a chronic inflammatory liver disease. Unknown triggers lead to a mainly T cell-mediated immune response targeting the liver, the main auto-antigen of which has not been identified yet. The diagnosis of autoimmune hepatitis is based on the elevation of immunoglobulin G/hypergammaglobulinemia, detection of characteristic autoantibodies as well as a typical pattern on liver histology. Exclusion of other causes of hepatitis and response to immunosuppressive treatment support the diagnosis of autoimmune hepatitis...
April 22, 2017: Liver International: Official Journal of the International Association for the Study of the Liver
https://www.readbyqxmd.com/read/28432810/liver-cirrhosis-is-a-risk-factor-for-atrial-fibrillation-a-nationwide-population-based-study
#15
HyunJung Lee, Eue-Keun Choi, Tae-Min Rhee, So-Ryoung Lee, Woo-Hyun Lim, Si-Hyuck Kang, Kyung-Do Han, Myung-Jin Cha, Seil Oh
BACKGROUND & AIMS: Information is lacking regarding whether liver cirrhosis (LC) is associated with atrial fibrillation (AF) development. We aimed to investigate the incidence and clinical significance of AF in cirrhotic patients. METHODS: LC patients (n = 3,596; mean age, 54.7 ± 12.3 years; male, 72.5%) without previous AF were selected from the Korean National Health Insurance Service National Sample Cohort database between 2004 and 2008. Age- and sex-matched controls (n=17,980) were randomly sampled in a 5:1 ratio from non-LC individuals...
April 22, 2017: Liver International: Official Journal of the International Association for the Study of the Liver
https://www.readbyqxmd.com/read/28423231/direct-acting-antiviral-therapy-decreases-hepatocellular-carcinoma-recurrence-rate-in-cirrhotic-patients-with-chronic-hepatitis-c
#16
Victor Virlogeux, Pierre Pradat, Kerstin Hartig-Lavie, François Bailly, Marianne Maynard, Guillaume Ouziel, Domitille Poinsot, Fanny Lebossé, Marie Ecochard, Sylvie Radenne, Samir Benmakhlouf, Joseph Koffi, Philippe Lack, Caroline Scholtes, Anne-Claire Uhres, Christian Ducerf, Jean-Yves Mabrut, Agnès Rode, Massimo Levrero, Christophe Combet, Philippe Merle, Fabien Zoulim
BACKGROUND AND AIMS: Arrival of direct-acting antiviral (DAA) agents against hepatitis C virus (HCV) with high-sustained virological response (SVR) rates and very few side effects has drastically changed the management of HCV infection. The impact of DAA exposure on hepatocellular carcinoma (HCC) recurrence after a first remission in patients with advanced fibrosis remains to be clarified. METHODS: 68 consecutive HCV patients with a first HCC diagnosis and under remission, subsequently treated or not with a DAA combination, were included...
April 19, 2017: Liver International: Official Journal of the International Association for the Study of the Liver
https://www.readbyqxmd.com/read/28423229/profile-and-outcome-of-first-109-cases-of-paediatric-acute-liver-failure-at-a-specialized-paediatric-liver-unit-in-india-methodological-issues
#17
LETTER
Erfan Ayubi, Saeid Safiri
We have meticulously read the article authored by Alam and colleagues published in the journal of Liver International in 2017.(1) The authors purposed to assess the aetiological spectrum and outcome of the paediatric acute liver failure cases. They conducted the study on 109 children with acute liver failure and found that jaundice to encephalopathy interval >7 days (J-E interval >7 days) and higher paediatric/model for end-stage liver disease scores at 72 hours (PELD at 72 h) were associated with poor outcome...
April 19, 2017: Liver International: Official Journal of the International Association for the Study of the Liver
https://www.readbyqxmd.com/read/28418617/improved-survival-of-patients-with-hepatocellular-carcinoma-and-compensated-hcv-related-cirrhosis-who-attained-svr
#18
Savino Bruno, Vito Di Marco, Massimo Iavarone, Luigi Roffi, Vincenzo Boccaccio, Andrea Crosignani, Giuseppe Cabibbo, Sonia Rossi, Vincenza Calvaruso, Alessio Aghemo, Luca Giacomelli, Antonio Craxì, Massimo Colombo, Patrick Maisonneuve
BACKGROUND: Few studies examined the outcome of patients with HCV-related cirrhosis who developed hepatocellular carcinoma (HCC). The relative weight as determinant of death for cancer versus end-stage-liver-disease (ESLD) and the benefit of HCV eradication remain undefined. This multicenter, retrospective analysis evaluates overall survival (OS), rate of decompensation and tumor recurrence in compensated HCC patients treated with IFN according to HCV status since HCC diagnosis. METHODS: Two groups of patients with HCV-related cirrhosis and HCC were followed since HCC diagnosis: (i) compensated cirrhotics with prior sustained virologic response (SVR) on IFN-based regimens (N=19); (ii) compensated cirrhotics without SVR (viremic) (N=156)...
April 18, 2017: Liver International: Official Journal of the International Association for the Study of the Liver
https://www.readbyqxmd.com/read/28418595/validation-of-page-b-model-in-asian-chronic-hepatitis-b-patients-receiving-entecavir-or-tenofovir
#19
Mi Na Kim, Seong Gyu Hwang, Kyu Sung Rim, Beom Kyung Kim, Jun Yong Park, Do Young Kim, Sang Hoon Ahn, Kwang-Hyub Han, Seung Up Kim
BACKGROUND & AIMS: A new hepatocellular carcinoma (HCC) risk prediction model, PAGE-B, which includes age, gender, and platelet count as constituent variables, has recently been proposed in Caucasian chronic hepatitis B (CHB) patients. We validated PAGE-B model and compared its accuracy with that of conventional risk prediction models in Asian CHB patients. METHODS: CHB patients treated with entecavir or tenofovir were consecutively recruited. The performance of PAGE-B and three conventional risk prediction models (CU-HCC, GAG-HCC, and REACH-B) were analyzed...
April 18, 2017: Liver International: Official Journal of the International Association for the Study of the Liver
https://www.readbyqxmd.com/read/28407349/low-l-ficolin-associated-with-disease-severity-during-sepsis-in-adult-icu-patients
#20
LETTER
Ulf Kessler, Luregn J Schlapbach, Peter Klimek, Stephan M Jakob
No abstract text is available yet for this article.
April 13, 2017: Liver International: Official Journal of the International Association for the Study of the Liver
journal
journal
40341
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"