journal
MENU ▼
Read by QxMD icon Read
search

Current Drug Discovery Technologies

journal
https://www.readbyqxmd.com/read/29766814/effect-of-%C3%AE-d-mannuronic-acid-m2000-on-oxidative-stress-enzymes-gene-using-healthy-donor-peripheral-blood-mononuclear-cells-for-evaluating-the-anti-aging-property
#1
Mahsa Taeb, Abdollah Jafarzadeh, Seyed Shahabeddin Mortazavi-Jahromi, Nahid Zainodini, Mohammad Reza Mirzaei, Fahimeh Jafarnezhad-Ansariha, Zahra Aghazadeh, Abbas Mirshafiey
OBJECTIVE: This research aimed to study the anti-aging and anti-inflammatory effects of low and high doses of the β-D-mannuronic (M2000) on gene expression of enzymes involved in oxidative stress (including SOD2, GST, GPX1, CAT, iNOS, and MPO) in peripheral blood mononuclear cells (PBMCs) of healthy donors under in vitro conditions. METHODS: The PBMCs were separated and the RNAs were then extracted and the cDNAs synthesized, and expression levels of the mentioned genes were detected by qRT-PCR...
May 15, 2018: Current Drug Discovery Technologies
https://www.readbyqxmd.com/read/29732990/ozenoxacin-a-novel-drug-discovery-for-the-treatment-of-impetigo
#2
Jagdish K Sahu, Arun K Mishra
OBJECTIVE: Ozenoxacin is one of the potent quinolone antibiotics, recently approved by the United States Food and Drug Administration (USFDA) with reported pharmacology to treat the impetigo. The demand for better acting topical formulation is increasing day by day. The present review is an attempt to summarize the facts behind the chemistry and biological applications of Ozenoxacin. Mechanism of action: This novel drug being a quinolone antibiotic compound, acts by inhibiting DNA gyrase A and topoisomerase IV and affects supercoiling, supercoil relaxation, chromosomal condensation, chromosomal decatenation and many others...
May 2, 2018: Current Drug Discovery Technologies
https://www.readbyqxmd.com/read/29732989/towards-breast-cancer-vaccines-progress-and-challenges
#3
Javad Behravan, Atefeh Razazan, Ghazal Behravan
Breast cancer is the second leading cause of cancer death among women. National cancer institute of the US estimates that one in eight women will be diagnosed with breast cancer during their life time. Considering the devastating effects of the disease and the alarming numbers many scientists and research groups have devoted their research to fight breast cancer. Several recommendations are to be considered as preventing measures which include living a healthy life style, regular physical activity, weight control and, smoking cessation...
May 2, 2018: Current Drug Discovery Technologies
https://www.readbyqxmd.com/read/29683093/a-novel-fluorescence-based-screen-for-inhibitors-of-the-initiation-of-dna-replication-in-bacteria
#4
Rasmus N Klitgaard, Anders Lobner-Olesen
BACKGROUND: One of many strategies to overcome antibiotic resistance is the discovery of compounds targeting cellular processes, which have not yet been exploited. METHODS AND MATERIALS: Using various genetic tools, we constructed a novel high throughput, cell based, fluorescence screen for inhibitors of chromosome replication initiation in bacteria. RESULTS: The screen was validated by expression of an intra-cellular cyclic peptide interfering with the initiator protein DnaA and by over-expression of the negative initiation regulator SeqA...
April 22, 2018: Current Drug Discovery Technologies
https://www.readbyqxmd.com/read/29692252/epigenetics-nutrition-disease-and-drug-development
#5
Kenneth Lundstrom
Epigenetic mechanisms comprising of DNA methylation, histone modifications and gene silencing by RNA interference have been strongly linked to the development and progression of various diseases. These findings have triggered research on epigenetic functions and signal pathways as targets for novel drug discovery. Dietary intake has also presented significant influence on human health and disease development and nutritional modifications have proven important in prevention, but also treatment of disease. Moreover, a strong link between nutrition and epigenetic changes has been established...
April 19, 2018: Current Drug Discovery Technologies
https://www.readbyqxmd.com/read/29676232/pharmacoepigenetics-and-pharmacoepigenomics-an-overview
#6
Jacob Peedicayil
The rapid and major advances being made in epigenetics is impacting pharmacology, giving rise to new sub-disciplines in pharmacology, pharmacoepigenetics, the study of the epigenetic basis of variation in response to drugs; and pharmacoepigenomics, the application of pharmacoepigenetics on a genome-wide scale. This article gives an overview of the current state of knowledge of pharmacoepigenetics and pharmacoepigenomics. The article highlights the following areas: epigenetic therapy, the role of epigenetics in pharmacokinetics, the relevance of epigenetics to adverse drug reactions, personalized medicine, drug addiction, and drug resistance, and the use of epigenetic biomarkers in drug therapy...
April 19, 2018: Current Drug Discovery Technologies
https://www.readbyqxmd.com/read/29669501/biopharmaceutical-potential-of-selegiline-loaded-chitosan-nanoparticles-in-the-management-of-parkinson-s-disease
#7
Rajalakshmi Rukmangathen, Indira Muzib Yallamalli, Prasanna Raju Yalavarthi
Selegiline hydrochloride, a hydrophilic anti-Parkinson' moiety, undergoes extensive first-pass metabolism and has low bioavailability. A process to obtain of selegiline (SH) loaded chitosan nanoparticles was attempted to circumvent the above problem, through intranasal delivery. SH loaded polymeric nanoparticles were prepared by ionic gelation of chitosan with tripolyphosphate, and stabilized by tween 80/ poloxamer 188. The resulting nanoparticles (NPs) were characterized by Fourier transform infrared spectroscopy, differential scanning calorimetry, entrapment efficiency, particle size, zeta potential and surface morphology by scanning electron microscopy...
April 18, 2018: Current Drug Discovery Technologies
https://www.readbyqxmd.com/read/29669500/%C3%AE-cell-regenerative-potential-of-selected-herbal-extracts-in-alloxan-induced-diabetic-rats
#8
Anoja Priyadarshani Attanayake, Kamani Ayoma Perera Wijewardana Jayatilaka, Lakmini Kumari Boralugoda Mudduwa, Chitra Pathirana
Effective β-cell regeneration is a recognized therapeutic strategy in the treatment of type 1 diabetes mellitus. Regeneration of β-cells could be achieved via exogenous natural sources as medicinal plant extracts. Medicinal plants selected for the investigation were Spondias pinnata (Linn. f.) Kurz, Coccinia grandis (L.) Voigt and Gmelina arborea Roxb. The objective was to determine the β-cell regenerative potential of these plant extracts in alloxan induced diabetic rats. Alloxan monohydrate was used to induce diabetes (150 mg/kg, ip)...
April 18, 2018: Current Drug Discovery Technologies
https://www.readbyqxmd.com/read/29669499/qsar-study-of-some-1-3-oxazolylphosphonium-derivatives-as-new-potent-anti-candida-agents-and-their-toxicity-evaluation
#9
Maria M Trush, Vasyl Kovalishyn, Alla D Ocheretniuk, Oleksandr L Kobzar, Maryna V Kachaeva, Volodymyr S Brovarets, Larisa O Metelytsia
This paper describes QSAR studies by using the Online Chemical Modeling Environment, synthesis, in vitro antifungal activity of 1,3-oxazolylphosphonium derivatives and their acetylcholinesterase inhibitory potential. Three classification QSAR models were created using Random Forests (WEKA-RF), k-Nearest Neighbors and Associative Neural Networks methods and different combinations of descriptors. The predictive ability of the models was tested through cross-validation, giving a balanced accuracy BA=80-91%. All compounds demonstrated good antifungal properties and slight inhibition of acetylcholinesterase activity...
April 18, 2018: Current Drug Discovery Technologies
https://www.readbyqxmd.com/read/29669498/an-indian-desert-shrub-hiran-chabba-farsetia-hamiltonii-royle-exhibits-potent-antioxidant-and-hepatoprotective-effect-against-iron-overload-induced-liver-toxicity-in-swiss-albino-mice
#10
Tapasree Basu, Bipul Kumar, Anil Khushalrao Shendge, Sourav Panja, Heerak Chugh, Hemant K Gautam, Nripendranath Mandal
BACKGROUND: Farsetia hamiltonii Royle, also known as Hiran Chabba grows in desert regions. It is widely used as folk medicine to treat joint pains, diarrhea and diabetes. However, its antioxidant and iron chelation abilities both in vitro and in vivo have not yet been investigated. METHODS: The 70% methanolic extract of F.hamiltonii (FHME) was investigated for its free radical scavenging and iron chelation potential, in vitro. An iron-overload situation was established by intraperitoneal injection of iron-dextran in Swiss albino mice, followed by oral administration of FHME...
April 18, 2018: Current Drug Discovery Technologies
https://www.readbyqxmd.com/read/29663890/methodologies-related-to-computational-models-in-view-of-developing-anti-alzheimer-drugs-an-overview
#11
Kirtee Baheti, Mayura Ajay Kale
BACKGROUND: Since last two decades, there has been more focus on the development strategies related to Anti-Alzheimer's drug research. This may be attributed to the fact that most of the Alzheimer's cases are still mostly unknown except for a few cases, where genetic differences have been identified. With the progress of the disease, the symptoms involve intellectual deterioration, memory impairment, abnormal personality and behavioural patterns, confusion, aggression, mood swings, irritability Current therapies available for this disease give only symptomatic relief and do not focus on manipulations of biololecular processes...
April 17, 2018: Current Drug Discovery Technologies
https://www.readbyqxmd.com/read/29623844/in-vitro-and-in-vivo-assessment-of-silver-nanoparticles-against-clostridium-botulinum-type-a-botulinum
#12
Mohammad Aminianfar, Siavash Parvardeh, Mohsen Soleimani
BACKGROUND: Clostridium botulinum causes botulism, resulting from the ingestion of a botulinal toxin, which is a serious paralytic illness. Due to strong antimicrobial activity of silver nanoparticles' products, the applications of silver nanoparticles in the field of healthcare in particular are being expanded. Therefore, the objective of current study was to assess a therapeutic strategy for the treatment of botulism toxicity using silver nanoparticles. METHODS: A preliminary test was conducted, based on the ranges that produce illness in laboratory animals, to determine absolute lethal dose (LD100) of botulinum toxin type A (BoNT/A) in mice...
April 3, 2018: Current Drug Discovery Technologies
https://www.readbyqxmd.com/read/29600768/the-hepato-protective-effects-of-portulaca-oleracea-l-extract-review
#13
Tahereh Farkhondeh, Saeed Samarghandian, Mohsen Azimi-Nezhad, Soroush Hozeifi
Portulaca oleracea L. (Purslane) has been used in traditional medicine against hepatic injury, alt-hough its actual efficacy has not been fully understood. In addition, few studies have indicated that Portulaca oleracea L. possess protective effects against hepatotoxic agents. However, due to lack of information in human, more studies are needed to confirm the efficacy of Portulaca oleracea L. as a hepato-protective agent. The present study aimed to critically review the recent literature data from 1990 to 2017 regarding the hepato-protective effects of Portulaca oleracea L...
March 30, 2018: Current Drug Discovery Technologies
https://www.readbyqxmd.com/read/29557751/date-palm-phoenix-dactylifera-novel-findings-and-future-directions-for-food-and-drug-discovery
#14
Ali H El-Far, Babatunji Emmanuel Oyinloye, Masood Sepehrimanesh, Mahmoud A Gab Allah, Ibrahim Abu Reidah, Hazem M Shaheen, Iman Razeghian-Jahromi, Abd El-Wahab A Alsenosy, Ahmed E Noreldin, Soad K Al Jaouni, Shaker A Mousa
Phoenix dactylifera is a useful traditional medicinal plant, mainly the fruit is used, which is the edible part of the plant (Ajwa date). It is now considered to be a valuable source of natural medicinal products against various diseases. Phytochemical investigations have shown that the fruit contains anthocyanins, phenolics, sterols, carotenoids, and flavonoids. The fruits are a rich source of carbohydrates, vitamins, and proteins. P. dactylifera is considered as a complete diet because it also contains different fatty acids, amino acids, proteins, and steroidal substances...
March 19, 2018: Current Drug Discovery Technologies
https://www.readbyqxmd.com/read/29521241/beta-vulgaris-a-mini-review-of-traditional-uses-in-iran-phytochemistry-and-pharmacology
#15
Shokouhsadat Hamedi, Masoud Honarvar
BACKGROUND: Beta vulgaris (family: Chenopodiacea) is now much used in the food industry as a rich source of sugar but it is much less considered in medicine. Beet has been used in traditional medicine for hundreds of years to treat a variety of diseases such as constipation, decreased libido, gut and joint pain and dandruff. METHODS: This study introduced the benefits of Beta vulgaris by reviewing of Iranian traditional documents from 10th century until now and also compared modern phytotherapy of plant beet from the electronic data banks such as ISI, Pub Med and Scopus with findings that extracted from traditional literature...
March 8, 2018: Current Drug Discovery Technologies
https://www.readbyqxmd.com/read/29521240/brassica-nigra-ethopharmacological-review-of-a-routinely-used-condiment
#16
Surendra S Agrawal, Tapasya P Yallatikar, Pravina N Gurjar
Brassica nigra belonging to the family Brassicaceae (syn - black mustard) comprises of dried seeds and is widely cultivated in Mediterranean region and various other countries like India and Europe. B. nigra contains glycosinolates which undergoes hydrolysis in the presence of myrosinase enzyme yields allyl isothiocyante. The bitter taste and pungent odor is due to the isothiocyanates. B. Nigra shows various activities that are medically important such as anticancer, anti-bacterial, anti-fungal, anti-helminthic, protection against renal and hepatic toxicity and can also be used in diabetes treatment...
March 8, 2018: Current Drug Discovery Technologies
https://www.readbyqxmd.com/read/29521239/hypnotic-effect-of-portulaca-oleracea-l-on-pentobarbital-induced-sleep-in-mice
#17
Shokouhsadat Hamedi, Fatemeh Forouzanfar, Hasan Rakhshandeh, Amirali Arian
OBJECTIVE: In Iranian Traditional Medicine, the herbs with cold and wet temperament can help to improve insomnia. Portulaca oleracea has cold and wet temperament, so the present study was carried out to investigate the sleep-prolonging effect of Portulaca oleracea. METHODS: This work was an experimental study on mice which were randomly divided into these groups: saline (control); Diazepam:) positive control); hydro-alcoholic extract of Portulaca oleracea (12.5, 25, 50, 75 and 100 mg/kg) by Soxhlet apparatus and maceration; in the effective (dose25 mg/kg), different fractions of extract were tested...
March 8, 2018: Current Drug Discovery Technologies
https://www.readbyqxmd.com/read/29521238/quality-by-design-concept-to-applications
#18
Suryakanta Swain, Rabinarayan Padhy, Bikash Ranjan Jena, Sitty Manohar Babu
BACKGROUND: Quality by Design is associated to the modern, systematic, scientific and novel approach which is concerned with pre-distinct objectives that not only focus on product, process understanding but also leads to process control. It predominantly signifies the design and product improvement and the manufacturing process in order to fulfill the predefined manufactured goods or final products quality characteristics. It is quite essential to identify desire and required product performance report such as Target Product Profile, typical Quality Target Product Profile (QTPP) and Critical Quality attributes (CQA)...
March 8, 2018: Current Drug Discovery Technologies
https://www.readbyqxmd.com/read/29493458/critical-insight-into-design-of-ppar-%C3%AE-agonists-by-virtual-screening-techniques
#19
Neelaveni Thangavel, Mohammad Al Bratty, Sadique Akhtar Javed, Waquar Ahsan, Hassan Al Hazmi
Design of novel PPAR-γ modulators with better binding efficiency and fewer side effects to treat type 2 diabetes is still a challenge for medicinal chemists. Cost and time efficient computational methods have presently become an integral part of research in nuclear receptors and their ligands, enabling hit to lead identification and lead optimization. This review will focus on cutting-edge technologies used in most recent studies on the design of PPAR- γ agonists and will discuss the chemistry of a few molecules which emerged successful...
February 27, 2018: Current Drug Discovery Technologies
https://www.readbyqxmd.com/read/29493457/the-modulatory-effect-of-lead-drug-candidates-on-inflammatory-gene-expression-in-sepsis-a-mini-review
#20
Samuel Mawuli Adadey, Michael Bright Yakass, Seth Agyemang, Samuel Duodu
Sepsis is a debilitating clinical syndrome of systemic inflammation in response to microorganisms especially Gram positive and Gram negative bacteria. A minority of sepsis cases could be due to non-pathogenic insult such as trauma. Much of the tissue and organ injury observed among septic patients is a consequence of the inflammatory response. The search for effective treatments of sepsis has led to several studies by different research groups across the globe. Although many targets and molecules have been identified, there is still no effective treatment for sepsis...
February 27, 2018: Current Drug Discovery Technologies
journal
journal
40309
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"